研究者データベース

門田 文

  • NCD疫学研究センター 准教授
Last Updated :2022/11/30

研究者情報

所属

  • NCD疫学研究センター 准教授

職名

  • 准教授

学位

  • 博士(医学)(滋賀医科大学)

ホームページURL

科研費研究者番号

  • 60546068

J-Global ID

研究キーワード

  • 循環器疾患   糖尿病   疫学   公衆衛生学   

研究分野

  • ライフサイエンス / 医療管理学、医療系社会学
  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

研究活動情報

論文

  • Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima
    Journal of atherosclerosis and thrombosis 2022年09月 研究論文(学術雑誌) 
    AIMS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in high-risk patients. However, the influence of circulating PCSK9 concentration on atherosclerotic plaque formation in the general population remains unknown. We assessed the relationship between serum PCSK9 concentration and coronary artery calcium (CAC) prevalence in the general population. METHODS: Community-dwelling Japanese men (n=622) aged 46-82 years without a history of cardiovascular disease and lipid-lowering medications were included. Serum PCSK9 concentration and CAC score were measured using the Agatston method, and the multivariable analysis was used to assess their association. CAC was defined as an Agatston score of >10. We conducted further analysis stratified by age (<60, 60-69, and ≥ 70 years). RESULTS: The average age, LDL-C, and median serum PCSK9 concentration were 68 years, 122 mg/dL, and 240 ng/mL, respectively. After multivariable adjustment for traditional cardiovascular risk factors, no significant association was observed between serum PCSK9 concentration and CAC prevalence (adjusted relative risk [aRR] 1.05, 95% confidence interval [CI] 0.97-1.13). With age stratification, serum PCSK9 concentration was significantly associated with CAC prevalence in men aged <60 years (aRR 1.38, 95% CI 1.01-1.88) but not in men aged 60-69 years (aRR 0.96, 95% CI 0.85-1.10) or ≥ 70 years (aRR 1.08, 95% CI 0.99-1.19). CONCLUSIONS: A higher serum PCSK9 concentration was associated with a higher CAC prevalence in men aged <60 years, which was independent of traditional cardiovascular risk factors.
  • Kota Kubo, Tomonori Okamura, Daisuke Sugiyama, Takashi Hisamatsu, Aya Hirata, Aya Kadota, Keiko Kondo, Takumi Hirata, Aya Higashiyama, Takehito Hayakawa, Yoshihiro Miyamoto, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima
    The American journal of cardiology 2022年09月 研究論文(学術雑誌) 
    The relation between chronic kidney disease (CKD) and cardiovascular disease (CVD) in the general population is well elucidated. In patients with CKD, anemia is associated with adverse outcomes. However, the effects of CKD and anemia on CVD in the general population remains poorly explored, especially in Asian populations. This study aimed to investigate the effect of CKD and/or anemia on CVD mortality in a long-term cohort study involving Japanese community dwellers. We assessed 7,339 participants (aged ≥30 years) with no CVD history. These participants were divided into 4 categories according to their CKD (estimated glomerular filtration rate <60 or urine protein >1+ by dipstick qualitative test) and/or anemia (hemoglobin: <13 g/100 ml [men], <12 g/100 ml [women]) statuses. For each category, we calculated the hazard ratios (HRs) of CVD mortality by using the Cox proportional hazards model after adjusting for age, body mass index, hypertension, diabetes, dyslipidemia, smoking, and alcohol drinking. Within 25 years of follow-up, 637 participants died because of CVD. The HRs of CVD in patients with CKD only, anemia only, and both were 1.27, 1.59, and 2.60 (95% confidence intervals [CI] 1.06 to 1.53, 1.34 to 1.90, and 1.80 to 3.76) in men and 1.42, 1.08, and 2.00 (95% CI 1.19 to 1.69, 0.99 to 1.18, and 1.54 to 2.60) in women, respectively. In conclusion, CKD with anemia is associated with an increased risk for CVD mortality in a general population in Japan.
  • Huynh Thi Hong Tram, Sachiko Tanaka-Mizuno, Naoyuki Takashima, Kawser Khan, Hisatomi Arima, Aya Kadota, Takako Fujii, Satoshi Shitara, Akihiro Kitamura, Naomi Miyamatsu, Yoshikuni Kita, Makoto Urushitani, Yoshihisa Nakagawa, Katsuyuki Miura, Kazuhiko Nozaki
    Cerebrovascular diseases (Basel, Switzerland) 1 - 8 2022年08月 研究論文(学術雑誌) 
    BACKGROUND: The relationship between diabetes control status and long-term prognosis after stroke incidence remains unclear. This study aimed to investigate the effect of diabetes status at admission on long-term survival in patients with first-ever stroke. METHODS: A retrospective cohort study was conducted based on the Shiga Stroke and Heart Attack Registry in Japan. Patients were classified according to their diabetes status and glycated hemoglobin (HbA1c) value at hospital admission into the following: (1) free of diabetes (no history of diabetes and HbA1c <6.5%); (2) good control (history of diabetes and HbA1c <7%; free of history and 6.5% ≤HbA1c <7%); and (3) poor control (with or without a history of diabetes and HbA1c ≥7%). Multivariable Cox regression models were used to evaluate the association between diabetes status and long-term survival from stroke onset. Additionally, we also evaluated the association between diabetes status and conditional survival, beginning 29 days after stroke onset. RESULTS: A total of 6,331 first-ever stroke patients were eligible for this study. Among study patients, the mean (±SD) age was 72.85 ± 13.19 years, and the mean (±SD) follow-up year was 2.76 ± 1.66 years; additionally, 42.09% of patients were women. Among patients with all strokes, considering the free-of-diabetes group as the reference group, the adjusted hazard ratio (95% confidence interval) for mortality was 1.26 (1.10, 1.44) in the good control group and 1.22 (1.05, 1.41) in the poor control group. Among patients with ischemic stroke, the adjusted hazard ratio was 1.24 (1.06, 1.46) in good control group and 1.27 (1.08, 1.50) in poor control group. After excluding patients who died within 28 days, the adjusted hazard ratio for conditional mortality in the poor control group was 1.31 (1.12, 1.54) among all stroke patients and 1.29 (1.08, 1.54) among ischemic stroke patients. No significant associations were observed between diabetic status and long-term mortality in intracerebral hemorrhage patients. CONCLUSIONS: The findings suggest that first-ever stroke patients with diabetes exhibited a higher risk of all-cause mortality than those without diabetes, particularly in the overall stroke and ischemic stroke populations. Additionally, in stroke populations after 28 days of onset, high risk of long-term mortality was stated in stroke patients with poor HbA1c control.
  • Takashi Hisamatsu, Katsuyuki Miura, Yasuharu Tabara, Yuichi Sawayama, Takashi Kadowaki, Aya Kadota, Sayuki Torii, Keiko Kondo, Yuichiro Yano, Akira Fujiyoshi, Takashi Yamamoto, Yoshihisa Nakagawa, Minoru Horie, Takeshi Kimura, Tomonori Okamura, Hirotsugu Ueshima
    European Journal of Preventive Cardiology 2022年07月 研究論文(学術雑誌) 
    Abstract Aims The potential effect of alcohol consumption on coronary heart disease (CHD) remains unclear. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate the causal role of alcohol intake in subclinical and clinical CHD. Methods We conducted two Mendelian randomization studies: a cross-sectional study of coronary artery calcification (CAC) on computed tomography of 1029 healthy men (mean age, 63.8 years) and a case-control study of 421 men with CHD (acute coronary syndrome [ACS] or stable angina pectoris) who underwent coronary revascularization and 842 age-matched male controls. Results In the CAC study, medians (25%tiles, 75%tiles) of alcohol consumption by ALDH2-rs671 *2 homozygotes (n = 86 [8.4%]), *1*2 heterozygotes (n = 397 [38.5%]), and *1 homozygotes (n = 546 [53.1%]) were 0.0 (0.0, 0.0), 28.0 (0.0, 129.0), and 224.0 (84.0, 350.0) g/week, respectively. In age-adjusted Poisson regression with robust error variance, compared with *2 homozygotes, relative risks for prevalent CAC score &gt;0, ≥100, and ≥300 in *1 homozygotes were 1.29 (95% confidence interval, 1.06-1.57), 1.76 (1.05-2.96), and 1.81 (0.80-4.09), respectively. In age-adjusted ordinal logistic regression for CAC distributions, we observed higher odds among *1 homozygotes (odds ratio, 2.19 [1.39-3.46]) and even among *1*2 heterozygotes (1.77 [1.11-2.82]) compared with *2 homozygotes. In the case-control study, conditional logistic regression revealed lower prevalence of *1 homozygotes among men with CHD (odds ratio, 0.54 [0.35-0.82]), especially ACS (0.46 [0.27-0.77]), than controls. Conclusion Our findings indicate a positive association of alcohol consumption with CAC burden but an inverse association with clinical CHD, especially ACS.
  • Yuichi Sawayama, Takashi Hisamatsu, Aya Kadota, Sayuki Torii, Keiko Kondo, Akira Fujiyoshi, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of hypertension 40 7 1344 - 1351 2022年07月 研究論文(学術雑誌) 
    OBJECTIVE: We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. METHODS: In this population-based, cross-sectional study, we assessed office BP, mean ambulatory BP (24-h, awake, and asleep), and variability of ambulatory BP, as determined by the coefficient of variation (awake and asleep). AVC and CAC were quantified using an Agatston score (>0) based on computed tomography scanning. We calculated relative risks (RRs) and 95% confidence intervals (CIs) with a 1-standard deviation increment in each BP index for the presence of AVC and CAC using a multivariate-adjusted Poisson regression with robust error variance. RESULTS: Of 483 participants (mean age: 66.8 years), 154 (31.9%) and 310 (64.2%) had AVC and CAC, respectively. The presence of AVC was associated with office systolic BP (SBP; RR, 1.15; 95% CI, 1.03-1.28), awake diastolic BP (DBP) variability (RR, 1.12; 95% CI, 1.01-1.25), and asleep SBP variability (RR, 1.14; 95% CI, 1.03-1.27). The presence of CAC was associated with office SBP (RR, 1.08; 95% CI, 1.01-1.15), mean 24-h SBP (RR, 1.10; 95% CI, 1.04-1.16), mean awake SBP (RR, 1.11; 95% CI, 1.04-1.17), mean asleep SBP (RR, 1.07; 95% CI, 1.01-1.13), and asleep SBP variability (RR, 1.07; 95% CI, 1.01-1.13). CONCLUSION: These findings highlight the association of ambulatory BP indices with both AVC and CAC, but with different effects on their presences.
  • Itsuko Miyazawa, Hiroshi Maegawa, Aya Kadota, Takashi Nakamura, Makoto Konishi, Shinichi Ochi, Katsuyuki Miura, Motozumi Okamoto
    Diabetology international 13 3 566 - 574 2022年07月 研究論文(学術雑誌) 
    Aim: To examine the trends in the management of patients with diabetes over an 18-year period in Japan. Participants and methods: We recorded the height, body mass, laboratory data, diabetes treatment, and screening status of diabetic complications from the data collected during the Shiga Diabetes Clinical Survey, which has been performed every 6 years since 2000. We then evaluated the management of patients with diabetes in Shiga Prefecture. The study included 17,870, 18,398, 24,243, and 26,624 participants in each of the 4 years of measurements. Results: The mean age and body mass index (BMI) of the participants gradually increased. The percentage of patients with BMI of ≥ 25 kg/m2 was higher in younger patients. Glycemic control significantly improved over 18 years (hemoglobin A1c: 7.3% ± 1.4% in 2000 to 7.1% ± 1.1% in 2018, P for trend < 0.001). The mean hemoglobin A1c levels were higher in younger patients than in elderly patients and increased from 2012 to 2018 in patients aged ≥ 65 years. The proportion of participants who underwent screening for albuminuria and diabetic retinopathy increased. The mean blood pressure and low-density lipoprotein cholesterol concentration decreased. Conclusions: Glycemic control has been maintained at an acceptable level since the previous survey. Although glycemic control has become less strict in elderly patients with diabetes, glycemic control is poorer in younger patients than in elderly patients. Obesity is an increasingly important problem, particularly in younger patients. The frequency of screening for diabetic complications and the control of blood pressure should be improved. Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-022-00573-2.
  • Phap Tran Ngoc Hoang, Aya Kadota, Yano Yuichiro, Harada Akiko, Hayakawa Takehito, Okamoto Shohei, Naoko Miyagawa, Keiko Kondo, Okuda Nagako, Yoshiuni Kita, Akira Okayama, Fujita Yukihiro, Hiroshi Maegawa, Katsuyuki Miura, Tomonori Okamura, Hirotsugu Ueshima
    Journal of diabetes investigation 2022年06月 研究論文(学術雑誌) 
    AIMS: To examine the association between diabetes and prediabetes at baseline and disability, mortality over a 22-year period among middle-aged adult Japanese. METHODS: Participants consisted of 1,788 adults aged 45 to 64 years at baseline from the cohort study NIPPON DATA90. Disability, defined as having decline in ADL, was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow-up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odd ratios were obtained from four models that contained appropriate adjustment factors such as age, sex, smoking status, drinking status, body mass index, and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein) at baseline. RESULTS: In the present study, 334 (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow-up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had higher risk for disability (OR = 1.43, 95%CI=1.07-1.91 and OR = 1.66, 95%CI=1.10-2.50, respectively) and for mortality (OR = 1.56, 95%CI=1.16-2.08 and OR = 1.77, 95%CI=1.18-2.65, respectively) than individuals with normal glucose tolerance. CONCLUSIONS: In middle-aged Japanese, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention and requires more intervention to prevent disability and mortality in later life.
  • 佐藤 敦, 有馬 久富, 田中 佐智子, 藤吉 朗, 門田 文, 三浦 克之, 上島 弘嗣, 岡村 智教, 村上 義孝
    日本循環器病予防学会誌 57 2 140 - 140 (一社)日本循環器病予防学会 2022年05月
  • Keiko Kondo, Hisatomi Arima, Akira Fujiyoshi, Akira Sekikawa, Aya Kadota, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Katsutaro Morino, Naoko Miyagawa, Hiroyoshi Segawa, Yoshiyuki Watanabe, Hiroshi Maegawa, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima
    Cerebrovascular diseases (Basel, Switzerland) 1 - 7 2022年04月 研究論文(学術雑誌) 
    BACKGROUND: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. METHODS: Participants were community-dwelling men (40-79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. RESULTS: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67-0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. CONCLUSIONS: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain.
  • Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura
    The American journal of cardiology 169 51 - 56 2022年04月 研究論文(学術雑誌) 
    Increased ventricular premature complexes (VPCs) are associated with a higher risk of cardiac morbidities. However, little information is available on the risk factors of Western general populations. Therefore, we aimed to assess the frequency and associated factors of VPCs in healthy general Japanese men. We conducted a population-based cross-sectional study in 517 men, aged 40 to 79 years, using 24-hour Holter electrocardiography. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, lipid-lowering therapy were included in multivariable negative binomial regression to assess independent correlates for the number of VPCs per hour. We observed at least 1 VPC in 1 hour in 429 men (83%). In multivariable negative binomial regression adjusted for all covariates simultaneously, age (risk ratio [95% confidence interval] 1.91 [1.56 to 2.33] per 1-SD increment), height (1.17 [1.04 to 1.49] per 1-SD increment), resting heart rate(1.34 [1.02 to 1.77] per 1-SD increment), diabetes mellitus (2.36 [1.17 to 4.76] ), hypertension (1.90 [1.03 to 3.50]), physical activity (0.67 [0.47 to 0.97] ), current smoking (4.23 [1.86 to 9.60] ), past smoking (2.08 [1.03 to 4.19] ), current light alcohol consumption (0.16 [0.04 to 0.64] ), and lipid-lowering therapy (0.47 [0.23 to 0.96] ) were independently associated with VPCs frequency. In conclusion, VPCs frequency was independently associated with age, height, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy.
  • Mizuki Ohashi, Katsuyuki Miura, Naoyuki Takashima, Aya Kadota, Yoshino Saito, Shunichiro Tsuji, Takashi Murakami, Yuka Kadomatsu, Mako Nagayoshi, Megumi Hara, Keitaro Tanaka, Takashi Tamura, Asahi Hishida, Toshiro Takezaki, Ippei Shimoshikiryo, Etsuko Ozaki, Isao Watanabe, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Sho Yamasaki, Hiroaki Ikezaki, Isao Oze, Yuriko N Koyanagi, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai
    Hypertension research : official journal of the Japanese Society of Hypertension 45 4 708 - 714 2022年04月 研究論文(学術雑誌) 
    Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.
  • Xiao Zhang, Akira Fujiyoshi, Vasudha Ahuja, Abhishek Vishnu, Emma Barinas-Mitchell, Aya Kadota, Katsuyuki Miura, Daniel Edmundowicz, Hirotsugu Ueshima, Akira Sekikawa
    International journal of cardiology 352 158 - 164 2022年04月 研究論文(学術雑誌) 
    BACKGROUND: Equol, an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed as equol-producers, might be the key anti-atherogenic component of ISFs. Our objective was to determine the association between equol-producing status and aortic atherosclerosis assessed as aortic calcification (AC). METHODS: This population-based study of 302 Japanese men aged 40-49, free of cardiovascular disease, examined serum levels of equol and ISFs, AC in the entire aorta by electron-beam computed tomography with Agatston method, and cardiovascular risk factors. We defined equol-producers as individuals with serum levels of equol ≥20 nM and prevalent AC as an AC score ≥ 10. We analyzed the association between equol-producing status and AC using Tobit and logistic regressions. We performed age-stratified analyses since age was a significant effect-modifier. RESULTS: The 70th to 90th percentile AC scores were 4 to 243 in equol-producers and 15 to 444 in non-producers, respectively. Overall, equol-producers (41% of the sample) had lower AC scores (-209, [95% confidence interval (CI): -455, 36]) and odds of AC (odds ratio (OR): 0.7 [95% CI: 0.4, 1.3]), although not statistically significant, compared to non-producers after controlling for cardiovascular risk factors. Among men aged 46-49, equol-producers had significantly lower AC scores (-428 [95% CI: -827, -29]). Furthermore, there were null associations between serum levels of ISFs and both AC score and the odds of AC. CONCLUSION: In middle-aged Japanese men, equol-producers had a non-significantly lower burden of aortic atherosclerosis than non-producers whereas ISFs had a null association. Studies with larger sample sizes in both sexes are warranted.
  • Jan Philipp Schuchardt, Marianna Cerrato, Martina Ceseri, Laura F DeFina, Graciela E Delgado, Sandra Gellert, Andreas Hahn, Barbara V Howard, Aya Kadota, Marcus E Kleber, Roberto Latini, Winfried Maerz, JoAnn E Manson, Samia Mora, Yongsoon Park, Aleix Sala-Vila, Clemens von Schacky, Akira Sekikawa, Nathan Tintle, Katherine L Tucker, Ramachandran S Vasan, William S Harris
    Prostaglandins, leukotrienes, and essential fatty acids 179 102418 - 102418 2022年04月 研究論文(学術雑誌) 
    Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different analytical methods have complicated inter-study and international comparisons. Here we report RBC FA data, with a focus on the Omega-3 Index (EPA + DHA in% of total FAs in RBC), from samples of seven countries (USA, Canada, Italy, Spain, Germany, South Korea, and Japan) including 167,347 individuals (93% of all samples were from the US). FA data were generated by a uniform methodology from a variety of interventional and observational studies and from clinical laboratories. The cohorts differed in size, demographics, health status, and year of collection. Only the Canadian cohort was a formal, representative population-based survey. The mean Omega-3 Index of each country was categorized as desirable (>8%), moderate (>6% to 8%), low (>4% to 6%), or very low (≤4%). Only cohorts from Alaska (treated separately from the US), South Korea and Japan showed a desirable Omega-3 Index. The Spanish cohort had a moderate Omega-3 Index, while cohorts from the US, Canada, Italy, and Germany were all classified as low. This study is limited by the use of cohorts of convenience and small sample sizes in some countries. Countries undertaking national health status studies should utilize a uniform method to measure Omega-3 FA levels.
  • Hiroaki Iwase, Sachiko Tanaka-Mizuno, Naoyuki Takashima, Aya Kadota, Kenji Matsui, Yasuyuki Nakamaura, Katsuyuki Miura, Hirotsugu Ueshima, Yoshikuni Kita
    BMC cardiovascular disorders 22 1 132 - 132 2022年03月 研究論文(学術雑誌) 
    BACKGROUND: High levels of participation in leisure-time and household physical activity lower the risk of cardiovascular disease (CVD), although it is unclear whether the number of activity types is related to new-onset CVD. We aimed to evaluate the effect of the amount of leisure-time physical activity and the number of types of leisure-time physical activities on the risk of CVD incidence. METHODS: From 2002 to 2003, 3,741 participants without any history of CVD participated in the Takashima Study. Data on the amount of leisure-time and household physical activity and the types of leisure-time and household physical activity were obtained from a self-administered questionnaire. Hazard ratios for CVD (acute myocardial infarction and stroke) incidence (follow-up data from 2002 to 2013), according to the participation level and number of activity types, were calculated using Cox proportional hazards models. RESULTS: The mean age of the subjects was 58.7 ± 13.1 years. During the mean follow-up period of 8.0 ± 1.1 years, 92 participants developed CVD. An inverse dose-response relationship was noted between the amount of leisure-time and household physical activity and CVD events. After adjusting for baseline characteristics, lifestyle-related diseases, and the amount of physical activity other than leisure-time and household, the risk of CVD onset was compared by dividing the participants into two groups by the level of participation; the highest activity group had an adjusted hazard ratio (95% confidence interval) of 0.40 (0.20-0.82) compared to the lowest activity group. Compared to participants who engaged in 0-1 type of activity, participants who engaged in two or more types of activities had a multivariable-adjusted hazard ratio (95% confidence interval) of 0.31 (0.12-0.79). CONCLUSION: Increasing the amount of leisure-time and household physical activity and promoting engagement in two or more types of such activities may reduce the rate of CVD incidence in the Japanese general population.
  • Mizuki Sata, Tomonori Okamura, Nobuo Nishi, Aya Kadota, Mieko Nakamura, Keiko Kondo, Yukiko Okami, Kaori Kitaoka, Toshiyuki Ojima, Katsushi Yoshita, Katsuyuki Miura
    Nutrients 14 6 2022年03月 研究論文(学術雑誌) 
    The prevalence of hypertension has been decreasing in Japan due to improved medical treatment and a decrease in dietary salt intake. However, disparities in the prevalence, treatment, and control of hypertension are expected to occur in different regions. This study aimed to investigate the trends in the prevalence, treatment, and control of hypertension at the prefectural level of life expectancy among Japanese population. We used data from the National Health and Nutrition Survey and analysed the individual survey information of individuals aged 40-69 years by dividing it into six terms, i.e., 1995-1997, 1999-2001, 2003-2005, 2007-2009, 2012, and 2016. Prefectures were classified into four groups according to their 40-year-old life expectancy in 2000. Outcome values were standardised to the population by 10-year age groups in 2010, and they were tested by two-way analysis of variance according to six terms and life expectancies. The prevalence of hypertension tended to decrease, especially among women, whereas the treatment and control tended to improve from the first to the sixth period in both men and women. The prevalence and treatment of hypertension in men with longer life expectancy tended to be lower than that in other groups, and there was no obvious difference in the control. In women, there were no obvious differences in the prevalence, treatment, or control. Reducing the prevalence of hypertension by improving lifestyle factors, such as high salt intake in each prefecture with a relatively short life expectancy, may be important to resolve the disparity in life expectancy among prefectures.
  • Naoyuki Takashima, Yasuyuki Nakamura, Naoko Miyagawa, Aya Kadota, Yoshino Saito, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima, Yoshikuni Kita
    Journal of atherosclerosis and thrombosis 2022年03月 研究論文(学術雑誌) 
    AIMS: High-sensitivity C-reactive protein (hsCRP) associates with atherosclerotic diseases such as stroke. However, previous results on the association between hsCRP levels and functional disability were controversial. METHODS: We analyzed 2,610 men and women who did not exhibit functional disability or death within the first 3 years of the baseline survey and those aged 65 years or older at the end of follow-up. The levels of hsCRP were assessed using latex agglutination assay at baseline survey from 2006 to 2014. Functional disability was followed up using the long-term care insurance (LTCI) program until November 1, 2019. Functional disability was defined as a new LTCI program certification. Cox proportional hazards model with competing risk analysis for death was used to evaluate the association between hsCRP levels and future functional disability. RESULTS: During a 9-year follow-up period, we observed 328 cases of functional disability and 67 deaths without prior functional disability incidence. The multivariable-adjusted hazard ratio (HR, 95% confidence interval [CI]) of functional disability in log-transferred hsCRP levels was 1.43 (1.22-1.67) in men and 0.97 (0.81-1.15) in women. When hsCRP level was analyzed as a categorical variable, low hsCRP levels (<1.0 mg/l) as the reference, the multivariable-adjusted HR (95% CI) of functional disability in high hsCRP levels (≥ 3.0 mg/l) was 2.37 (1.56-3.62). Similar results were observed when stratified by sex, but it was not significant in women. CONCLUSIONS: This study demonstrates that low-grade systemic inflammation to assess hsCRP might predict the future incidence of functional disability, especially in men.
  • 中川 夕美, 由田 克士, 荒井 裕介, 尾島 俊之, 藤吉 朗, 中川 秀昭, 奥田 奈賀子, 宮川 尚子, 門田 文, 近藤 慶子, 岡村 智教, 大久保 孝義, 西 信雄, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 57 1 42 - 54 (一社)日本循環器病予防学会 2022年03月 
    【目的】高血圧者に対する食事指導等の介入によって野菜摂取量の増加が認められたとする報告はこれまでにもあるが、高血圧を指摘されることそれ自体や治療の継続状況と野菜摂取量の関連を検討した報告はない。そこで本研究では、高血圧の指摘や治療の継続状況が、実際の野菜摂取量に影響を与えるのか検討した。【方法】平成22年国民健康・栄養調査及びNIPPON DATA2010の20歳以上の参加者を対象とした。このうち、これまでに医療機関や健康診査で脳卒中、心筋梗塞、腎臓病または腎機能低下と指摘されたことはないが、高血圧の指摘を受けている者もしくは高血圧、糖尿病、脂質異常症のいずれの指摘も受けたことはないが、国民健康・栄養調査の血圧測定値が高血圧(収縮期血圧140mmHg以上または拡張期血圧90mmHg以上の者と定義)であった高値血圧者の男女1,004人を解析対象とした。野菜摂取量が多いこと(1日350g以上)をアウトカムとして、高血圧を指摘されることやその後の治療の継続状況(治療継続、治療中断、未治療)との関連をロジスティック回帰分析にて検討した。【結果】野菜摂取量が多いことと高血圧を指摘されることは男女とも有意な関連はなく、野菜を積極的に摂取しようと心がけることとのオッズ比が男性1.72(95%CI:1.17-2.53)、女性1.51(95%CI:1.04-2.21)と有意な正の関連が認められた。野菜摂取量が多いことと高血圧者における治療の継続状況では、野菜を積極的に摂取しようと心がけることとのオッズ比が男性1.69(95%CI:1.07-2.68)と有意な正の関連、「治療中断」の女性でオッズ比0.37(95%CI:0.15-0.90)と有意な負の関連がみられた。【結論】男女とも野菜の摂取量と高血圧の指摘自体との関連は認められなかったが、女性では治療中断と負の関連が示唆された。(著者抄録)
  • 高血圧の指摘や治療の継続状況と野菜摂取量の関連 NIPPON DATA2010
    中川 夕美, 由田 克士, 荒井 裕介, 尾島 俊之, 藤吉 朗, 中川 秀昭, 奥田 奈賀子, 宮川 尚子, 門田 文, 近藤 慶子, 岡村 智教, 大久保 孝義, 西 信雄, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 57 1 42 - 54 (一社)日本循環器病予防学会 2022年03月 
    【目的】高血圧者に対する食事指導等の介入によって野菜摂取量の増加が認められたとする報告はこれまでにもあるが、高血圧を指摘されることそれ自体や治療の継続状況と野菜摂取量の関連を検討した報告はない。そこで本研究では、高血圧の指摘や治療の継続状況が、実際の野菜摂取量に影響を与えるのか検討した。【方法】平成22年国民健康・栄養調査及びNIPPON DATA2010の20歳以上の参加者を対象とした。このうち、これまでに医療機関や健康診査で脳卒中、心筋梗塞、腎臓病または腎機能低下と指摘されたことはないが、高血圧の指摘を受けている者もしくは高血圧、糖尿病、脂質異常症のいずれの指摘も受けたことはないが、国民健康・栄養調査の血圧測定値が高血圧(収縮期血圧140mmHg以上または拡張期血圧90mmHg以上の者と定義)であった高値血圧者の男女1,004人を解析対象とした。野菜摂取量が多いこと(1日350g以上)をアウトカムとして、高血圧を指摘されることやその後の治療の継続状況(治療継続、治療中断、未治療)との関連をロジスティック回帰分析にて検討した。【結果】野菜摂取量が多いことと高血圧を指摘されることは男女とも有意な関連はなく、野菜を積極的に摂取しようと心がけることとのオッズ比が男性1.72(95%CI:1.17-2.53)、女性1.51(95%CI:1.04-2.21)と有意な正の関連が認められた。野菜摂取量が多いことと高血圧者における治療の継続状況では、野菜を積極的に摂取しようと心がけることとのオッズ比が男性1.69(95%CI:1.07-2.68)と有意な正の関連、「治療中断」の女性でオッズ比0.37(95%CI:0.15-0.90)と有意な負の関連がみられた。【結論】男女とも野菜の摂取量と高血圧の指摘自体との関連は認められなかったが、女性では治療中断と負の関連が示唆された。(著者抄録)
  • Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura
    Circulation journal : official journal of the Japanese Circulation Society 86 8 1298 - 1306 2022年02月 研究論文(学術雑誌) 
    BACKGROUND: Premature atrial contractions (PACs) are predictors of atrial fibrillation, stroke, and cardiovascular mortality. The present study aimed to assess relevant factors for PACs among a general population of Japanese men.Methods and Results:This study conducted a population-based, cross-sectional study among 517 men, aged 40-79 years, with neither apparent myocardial infarction nor atrial fibrillation. 24-h Holter electrocardiography to assess PAC frequency was used. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, mean heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy were included in multivariable negative binomial regression analyses to assess correlation for the number of PACs per hour. Almost all participants (99%) had at least 1 PAC in 1 h (median number 2.84 PACs per h). In multivariable negative binomial regression after adjusting for all covariates simultaneously, age (relative risk [95% confidence interval], 1.30 [1.08-1.57] per 1-standard deviation [SD] increment), height (1.19 [1.02-1.39] per 1-SD increment), triglycerides (0.79 [0.65-0.97] per 1-SD increment), mean heart rate (0.69 [0.59-0.80] per 1-SD increment), physical activity (0.63 [0.43-0.93]), current smoking (1.69 [1.06-2.69]), current moderate (1.97 [1.23-3.16]) and heavy (1.84 [1.12-3.01]) alcohol consumption were independently associated with PAC frequency. CONCLUSIONS: PAC frequency was independently associated with age, height, smoking, alcohol consumption, heart rate, physical activity, and triglycerides.
  • Yasuyuki Nakamura, Takashi Tamura, Akira Narita, Atsushi Shimizu, Yoichi Sutoh, Naoyuki Takashima, Kenji Matsui, Naoko Miyagawa, Aya Kadota, Katsuyuki Miura, Jun Otonari, Hiroaki Ikezaki, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Keitaro Tanaka, Chisato Shimanoe, Rie Ibusuki, Daisaku Nishimoto, Isao Oze, Hidemi Ito, Etsuko Ozaki, Daisuke Matsui, Haruo Mikami, Miho Kusakabe, Sadao Suzuki, Miki Watanabe, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai
    European journal of clinical nutrition 76 8 1103 - 1110 2022年02月 研究論文(学術雑誌) 
    BACKGROUND/OBJECTIVES: Low-carbohydrate diets (LCD) are useful for weight reduction, and 50-55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences, and dietary patterns, but whether particular genetic differences in individuals influence LCD adherence is unknown. SUBJECTS/METHODS: We conducted a GWAS on adherence to LCD utilizing 14,076 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a previously validated semiquantitative food frequency questionnaire to estimate food consumption. Association of the imputed variants with the LCD score by Halton et al. we used linear regression analysis adjusting for sex, age, total dietary energy consumption, and components 1 to 10 by principal component analysis. We repeated the analysis with adjustment for alcohol consumption (g/day) in addition to the above-described variables. RESULTS: Men and women combined analysis without adjustment for alcohol consumption; we found 395 variants on chromosome 12 associated with the LCD score having P values <5 × 10-8. A conditional analysis with the addition of the dosage data of rs671 on chromosome 12 as a covariate, P values for all 395 SNPs on chromosome 12 turned out to be insignificant. In the analysis with additional adjustment for alcohol consumption, we did not identify any SNPs associated with the LCD score. CONCLUSION: We found rs671 was inversely associated with adherence to LCD, but that was strongly confounded by alcohol consumption.
  • Kayoko Koga, Megumi Hara, Chisato Shimanoe, Yuichiro Nishida, Takuma Furukawa, Chiharu Iwasaka, Keitaro Tanaka, Jun Otonari, Hiroaki Ikezaki, Yoko Kubo, Yasufumi Kato, Takashi Tamura, Asahi Hishida, Keitaro Matsuo, Hidemi Ito, Yohko Nakamura, Miho Kusakabe, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Miki Watanabe, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai
    Scientific reports 12 1 291 - 291 2022年01月 研究論文(学術雑誌) 
    Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.
  • 門田 文, 三浦 克之
    日本臨床 80 増刊1 最新臨床脳卒中学(上) 64 - 69 (株)日本臨床社 2022年01月
  • 日本人一般集団における慢性腎臓病と貧血の心血管死亡率への関連 NIPPON DATA 90
    久保 浩太, 岡村 智教, 杉山 大典, 久松 隆史, 門田 文, 近藤 慶子, 早川 岳人, 岡山 明, 三浦 克之, 上島 弘嗣, NIPPON DATA90研究グループ
    Journal of Epidemiology 32 Suppl.1 124 - 124 (一社)日本疫学会 2022年01月
  • 日本人一般集団における慢性腎臓病と貧血の心血管死亡率への関連 NIPPON DATA 90
    久保 浩太, 岡村 智教, 杉山 大典, 久松 隆史, 門田 文, 近藤 慶子, 早川 岳人, 岡山 明, 三浦 克之, 上島 弘嗣, NIPPON DATA90研究グループ
    Journal of Epidemiology 32 Suppl.1 124 - 124 (一社)日本疫学会 2022年01月
  • 門田 文, 三浦 克之
    日本臨床 80 増刊1 最新臨床脳卒中学(上) 64 - 69 (株)日本臨床社 2022年01月
  • Takuma Furukawa, Yuichiro Nishida, Megumi Hara, Chisato Shimanoe, Kayoko Koga, Chiharu Iwasaka, Yasuki Higaki, Keitaro Tanaka, Ryoko Nakashima, Hiroaki Ikezaki, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Yasuyuki Nakamura, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Takeuchi, Kenji Wakai
    BMJ open diabetes research & care 10 1 2022年01月 研究論文(学術雑誌) 
    INTRODUCTION: Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study of 55 469 men and women without diabetes who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. A self-administered questionnaire ascertained PA and macronutrient intake (carbohydrate, fat, and protein). Multiple linear regression analyses were performed to adjust for confounding variables and examine the interactions. In addition, we conducted a longitudinal study during a 5-year period within a subcohort (n=6881) with accelerometer-assessed PA data. RESULTS: Overall, PA had a weak inverse association (β=-0.00033, p=0.049) and carbohydrate intake had a strong positive association (β=0.00393, p<0.001) with HbA1c. We observed a tendency of interactions between PA and carbohydrate or fat intake, but not protein intake, on HbA1c levels after adjusting for age, sex, study area, total energy intake, alcohol consumption, smoking, and medication for hypertension or hypercholesterolemia (Pinteraction=0.054, 0.006, and 0.156, respectively). The inverse associations between PA and HbA1c level were more evident in participants with high-carbohydrate (or low-fat) intake than in participants with low-carbohydrate (or high-fat) intake. Although further adjustment for body mass index slightly attenuated the above interactions (Pinteraction=0.098 for carbohydrate and 0.068 for fat), the associations between PA and HbA1c level in stratified analyses remained unchanged. Similar associations and interactions were reproduced in the longitudinal study. CONCLUSIONS: The present results suggest that the effect of PA on HbA1c levels is modified by intake of macronutrient composition.
  • Yoshino Saito, Katsuyuki Miura, Hisatomi Arima, Takehito Hayakawa, Naoyuki Takashima, Yoshikuni Kita, Nagako Okuda, Akira Fujiyoshi, Toshiyuki Iwahori, Naoko Miyagawa, Keiko Kondo, Sayuki Torii, Aya Kadota, Takayoshi Ohkubo, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
    PloS one 17 2 e0261716  2022年 研究論文(学術雑誌) 
    OBJECTIVE: This study aimed to investigate the incidence rates and predictors of lower limb fractures in a general Japanese population. METHODS: NIPPON DATA is a nationwide, long-term, prospective cohort study of individuals who participated in the National Cardiovascular Survey Japan and the National Nutrition Survey in 1990. Overall, 3,134 individuals (1,827 women, 1,307 men) who participated in follow-up assessments in 1995, 2000, and/or 2006 were included in the present analysis. The outcomes of this study were lower limb fractures (including proximal femur fractures). RESULTS: The mean age at baseline was 63.8 years in women and 63.1 years in men. The average body mass index (BMI) was 23.3 kg/m2 in women and 22.9 kg/m2 in men. During a mean follow-up of 12.1 years, 271 total lower limb fractures were observed. In women, older age, lower BMI, and less intake of vegetables were associated with increased risks of proximal femur fractures. With regard to the outcome of total lower limb fractures, less intake of vegetables and regular exercise were significant predictors in women. Calcium intake was not significantly associated with proximal femur or total lower limb fractures. There were no significant predictors of proximal femur or total lower limb fractures in men, except for age. CONCLUSIONS: Aging was a significant risk factor for proximal femur and total lower limb fractures in both men and women. With regard to modifiable risk factors, low BMI and low intake of vegetables were associated with increased risks of proximal femur and/or total lower limb fractures in the general population of Japanese women.
  • Tomiyo Nakamura, Yasuyuki Nakamura, Naoyuki Takashima, Aya Kadota, Katsuyuki Miura, Hirotsugu Ueshima, Yosikuni Kita
    Nutrients 14 1 2021年12月 研究論文(学術雑誌) 
    The double burden of malnutrition refers to the co-occurrence of overweight and obesity and undernutrition. Eating quickly has been linked to overweight and obesity. However, no study has examined the association between eating speed and undernutrition. This retrospective, cross-sectional study analyzed data from 3529 community-dwelling residents. Eating speed was divided into three categories: fast, medium, and slow. Undernutrition was defined as body mass index (BMI) of <18.5 kg/m2 in adults aged < 70 years (adults) and as <20 kg/m2 in adults aged ≥ 70 years (older adults), in accordance with the Global Leadership Initiative on Malnutrition criteria for Asians. Multivariable logistic regression analysis was used to examine the association between eating speed and undernutrition. Among adult men, compared with eating quickly, eating slowly was associated with elevated prevalence of undernutrition (odds ratio (OR) 9.68, 95% confidence interval (CI) 2.32-40.51, p = 0.001). Among older adult women, the prevalence of undernutrition in the slow-eating group was higher than that in the fast-eating group (OR 3.82, 95% Cl 1.51-9.69, p = 0.005). Eating slowly is independently associated with the prevalence of undernutrition among community-dwelling adult men and older adult women in Japan.
  • 飲酒と冠動脈石灰化・冠動脈疾患発症との関連 メンデルランダム化分析
    久松 隆史, 三浦 克之, 田原 康玄, 門脇 崇, 鳥居 さゆ希, 門田 文, 近藤 慶子, 藤吉 朗, 山本 孝, 中川 義久, 堀江 稔, 木村 剛, 岡村 智教, 上島 弘嗣
    日本アルコール・薬物医学会雑誌 56 6 281 - 281 (一社)日本アルコール・アディクション医学会 2021年12月
  • 新型コロナウイルス感染症緊急事態宣言下における国民の生活習慣の変化
    南 朗子, 門田 文, 大久保 孝義, 岡村 智教, 奥田 奈賀子, 西 信雄, 宮本 恵宏, 由田 克士, 尾島 俊之, 近藤 慶子, 早川 岳人, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 80回 506 - 506 日本公衆衛生学会 2021年11月
  • 新型コロナウイルス感染症緊急事態宣言下における国民の生活習慣の変化
    南 朗子, 門田 文, 大久保 孝義, 岡村 智教, 奥田 奈賀子, 西 信雄, 宮本 恵宏, 由田 克士, 尾島 俊之, 近藤 慶子, 早川 岳人, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 80回 506 - 506 日本公衆衛生学会 2021年11月
  • 西 信雄, 北岡 かおり, 岡見 雪子, 近藤 慶子, 佐田 みずき, 門田 文, 中村 美詠子, 尾島 俊之, 岡村 智教, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 3 258 - 264 (一社)日本循環器病予防学会 2021年11月 
    【目的】都道府県別の平均寿命の格差について、その要因を断面で検討した研究はいくつかあるが、経年的に平均寿命と生活習慣等との関連を検討した研究は見当たらない。本研究は、日本国民を代表する標本による国民健康・栄養調査(国民栄養調査)の約20年間のデータ推移分析により、国民の生活習慣病リスク要因の変化を生態学的研究により明らかにすることを目的とした。【方法】国民健康・栄養調査(国民栄養調査)の1995-2016年の結果について、1995-1997年(1期)、1999-2001年(2期)、2003-2005年(3期)、2007-2009年(4期)、2012年(5期)、2016年(6期)の14年分を分析対象とした。2000年の平均寿命別に都道府県を4群に分類し、body mass index(BMI)、腹囲、歩数、現在習慣的に喫煙している者の割合、現在飲酒者の割合、現在飲酒者における1日あたり平均飲酒量の推移を比較した。これらの数値または割合の比較においては、平均寿命別の4群の平均値の高低について、平均寿命をさらに延伸させると想定される場合を健康増進性が高いとした。分析対象は40歳から69歳とし、2010年の10歳階級別人口に基づき年齢調整した値について、年次推移に関する6期(腹囲と飲酒に関する調査項目については4期)と平均寿命による4群をもとに二元配置分散分析を行った。【結果】男性のBMI、腹囲、歩数、現在飲酒者における1日あたり平均飲酒量と女性の現在習慣的に喫煙している者の割合において平均寿命別の有意差がみられ、いずれも平均寿命が高い群で健康増進性が高い(または平均寿命が低い群で健康増進性が低い)数値または割合を示した。これらの調査項目については期別でも有意差がみられ、経年的な変化にもかかわらず平均寿命と関連する可能性が示された。【結論】国民健康・栄養調査の約20年間のデータをもとに都道府県単位の平均寿命別に生活習慣等の推移を生態学的研究により検討したところ、男性のBMIや腹囲等、女性の現在習慣的に喫煙している者の割合において有意差がみられた。都道府県別の平均寿命の格差を縮小するためには、特に平均寿命が比較的短い都道府県において生活習慣等を地域レベルで改善することが重点的課題であると考えられた。(著者抄録)
  • 都道府県単位の平均寿命別にみた国民健康・栄養調査結果における生活習慣等の推移
    西 信雄, 北岡 かおり, 岡見 雪子, 近藤 慶子, 佐田 みずき, 門田 文, 中村 美詠子, 尾島 俊之, 岡村 智教, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 3 258 - 264 (一社)日本循環器病予防学会 2021年11月 
    【目的】都道府県別の平均寿命の格差について、その要因を断面で検討した研究はいくつかあるが、経年的に平均寿命と生活習慣等との関連を検討した研究は見当たらない。本研究は、日本国民を代表する標本による国民健康・栄養調査(国民栄養調査)の約20年間のデータ推移分析により、国民の生活習慣病リスク要因の変化を生態学的研究により明らかにすることを目的とした。【方法】国民健康・栄養調査(国民栄養調査)の1995-2016年の結果について、1995-1997年(1期)、1999-2001年(2期)、2003-2005年(3期)、2007-2009年(4期)、2012年(5期)、2016年(6期)の14年分を分析対象とした。2000年の平均寿命別に都道府県を4群に分類し、body mass index(BMI)、腹囲、歩数、現在習慣的に喫煙している者の割合、現在飲酒者の割合、現在飲酒者における1日あたり平均飲酒量の推移を比較した。これらの数値または割合の比較においては、平均寿命別の4群の平均値の高低について、平均寿命をさらに延伸させると想定される場合を健康増進性が高いとした。分析対象は40歳から69歳とし、2010年の10歳階級別人口に基づき年齢調整した値について、年次推移に関する6期(腹囲と飲酒に関する調査項目については4期)と平均寿命による4群をもとに二元配置分散分析を行った。【結果】男性のBMI、腹囲、歩数、現在飲酒者における1日あたり平均飲酒量と女性の現在習慣的に喫煙している者の割合において平均寿命別の有意差がみられ、いずれも平均寿命が高い群で健康増進性が高い(または平均寿命が低い群で健康増進性が低い)数値または割合を示した。これらの調査項目については期別でも有意差がみられ、経年的な変化にもかかわらず平均寿命と関連する可能性が示された。【結論】国民健康・栄養調査の約20年間のデータをもとに都道府県単位の平均寿命別に生活習慣等の推移を生態学的研究により検討したところ、男性のBMIや腹囲等、女性の現在習慣的に喫煙している者の割合において有意差がみられた。都道府県別の平均寿命の格差を縮小するためには、特に平均寿命が比較的短い都道府県において生活習慣等を地域レベルで改善することが重点的課題であると考えられた。(著者抄録)
  • Namuun Ganbaatar, Aya Kadota, Takashi Hisamatsu, Shinichi Araki, Shinji Kume, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Hiroyoshi Segawa, Ebtehal Salman, Itsuko Miyazawa, Takashi Yamamoto, Yoshihisa Nakagawa, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of atherosclerosis and thrombosis 2021年10月 研究論文(学術雑誌) 
    AIMS: The roles of urinary albumin, eGFRcystatin (eGFRcys), and eGFRcreatinine (eGFRcre) in the progression of coronary artery calcification (CAC) remain unclear. Therefore, the present study investigated the relationship between kidney function and CAC progression. METHODS: A total of 760 Japanese men aged 40-79 years were enrolled in this population-based study. Kidney function was measured using eGFRcre, eGFRcys, and the urine albumin-to-creatinine ratio. CAC scores were calculated using the Agatston method. CAC progression was defined as an annual increase of >10 Agatston units (AU) among men with 0<CAC<100 AU at baseline, that of >10% among those with CAC ≥ 100 AU, and any progression for those with CAC=0 at baseline. The relative risk (RR) of CAC progression based on kidney function was assessed using a robust Poisson regression model. RESULTS: The mean follow-up period was 4.9 years. CAC progression was detected in 45.8% of participants. Positive associations between CAC progression and albuminuria (>30mg/g) (RR: 1.29; 1.09 to 1.53; p=0.004) and low eGFRcys (<60ml/min/1.73m2) (RR: 1.27; 1.05 to 1.53; p=0.012) remained significant after adjustments for age, the follow-up time, and computerized tomography type. Following further adjustments for hypertension, diabetes mellitus, dyslipidemia, C-reactive protein, and lifestyle factors, CAC progression was associated with albuminuria (RR: 1.20; 1.01 to 1.43; p=0.04) and low eGFRcys (RR: 1.19; 0.99 to 1.43; p=0.066), but not with eGFRcre. CONCLUSION: CAC progression was associated with albuminuria; however, its relationship with eGFRcys was weakened by adjustments for risk factors.
  • Naoyuki Takashima, Yasuyuki Nakamura, Naoko Miyagawa, Aya Kadota, Sachiko Tanaka-Mizuno, Kenji Matsui, Katsuyuki Miura, Hirotsugu Ueshima, Yoshikuni Kita
    Gerontology 68 6 1 - 8 2021年09月 研究論文(学術雑誌) 
    BACKGROUND: Both physical and psychological factors have been associated with functional disability. However, the associations between stress-coping strategies and future functional disability remain unclear. METHODS: We analyzed 2,924 participants who did not have incidence of functional disability or death within the first 3 years of the baseline survey and were aged 65 years or more at the end of follow-up. Stress-coping strategies were assessed via a self-administered questionnaire (emotional expression, emotional support seeking, positive thought, problem-solving, and disengagement) in a baseline survey from 2006 to 2014. Levels of coping strategies were classified as low, middle, and high based of frequency. Functional disability decline was followed up using the long-term-care insurance program until November 1, 2019. Functional disability decline was defined as a new long-term-care insurance program certification. Cox proportional hazards model with competing risk analysis for death was used to evaluate associations between coping strategy levels and functional disability. RESULTS: During the follow-up period, we observed 341 cases of functional disability and 73 deaths without previous incidence of functional disability. A significant inverse association between "positive thought" and "problem-solving" and future functional disability was observed. Multivariable adjusted hazard ratios (95% confidence interval) for functional disability were 0.68 (0.51-0.92) for high levels of "positive thought" and 0.73 (0.55-0.95) for high levels of "problem-solving," compared with low levels of the coping strategies. The inverse association was stronger in men. CONCLUSIONS: Some subcomponents of stress-coping strategies might be associated with future incidence of functional disability among older adults.
  • Mako Nagayoshi, Kenji Takeuchi, Yudai Tamada, Kato Yasufumi, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Yuriko N Koyanagi, Keitaro Matsuo, Mikami Haruo, Kusakabe Miho, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai
    Journal of epidemiology 2021年09月 研究論文(学術雑誌) 
    BACKGROUND: Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults. METHODS: A total of 79,580 individuals aged 35-69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy "sometimes," and "often/very often" (versus "very few" use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated. RESULTS: During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs (95% confidence intervals) for "sometimes" were 0.81 (0.67-0.97) for emotional expression, 0.79 (0.66-0.95) for emotional support-seeking, and 0.80 (0.66-0.98) for disengagement. Men who "sometimes" used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15-41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (p for interaction = 0.03). CONCLUSIONS: In a large Japanese population, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women.
  • Yiwei Liu, Aya Hirata, Tomonori Okamura, Daisuke Sugiyama, Takumi Hirata, Aya Kadota, Keiko Kondo, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    Journal of epidemiology 2021年09月 研究論文(学術雑誌) 
    BackgroundElevated resting heart rate (RHR) is associated with an increased risk for cardiovascular disease (CVD) and all-cause mortality. However, the findings of cohort studies differed. Thus, the impact of RHR on CVD mortality might be different according to the background of the population. Therefore, we examined the relationship of RHR and CVD mortality according to serum ALB levels in a Japanese general population.MethodsIn total, 8363 individuals without a history of CVD were followed-up for 24.0 years. The participants were divided into four groups according to the quartiles of RHR (Q1-Q4), and they were further classified into the high and low ALB groups based on a median value of 44 g/L. We estimated the multivariable-adjusted hazard ratios (HRs) of CVD mortality in each RHR group based on ALB levels, and the interaction between RHR and ALB groups on CVD mortality was evaluated.ResultsWe found no significant association between RHR and CVD mortality. However, the Q4 of RHR was significantly associated with an increased risk for CVD mortality (HR: 1.27 [95% confidence interval, CI: 1.02-1.57]) in participants with a low ALB level. Meanwhile, the Q4 of RHR was significantly correlated with a decreased risk for CVD morality in those with a high ALB level (HR: 0.61 [95% CI: 0.47-0.79]) after adjusting for covariates. A significant interaction between RHR and ALB for CVD mortality was shown (p<0.001).ConclusionsThe impact of RHR on CVD mortality differed according to ALB levels in a general Japanese population.
  • Kawser Khan, Sachiko Tanaka-Mizuno, Tanvir C Turin, Naoyuki Takashima, Aya Kadota, Hirotsugu Ueshima, Katsuyuki Miura, Yoshikuni Kita
    Circulation journal : official journal of the Japanese Circulation Society 85 12 2215 - 2221 2021年07月 研究論文(学術雑誌) 
    BACKGROUND: Using a population-based stroke registry system, we evaluated the relationship between ambient temperature parameters and stroke incidence in a Japanese population.Methods and Results:We analyzed data from the Takashima Stroke Registry, which records all stroke occurrences in Takashima City, Japan. The study period of 8,401 days was divided into quintiles of daily weather parameters, and the middle quintile was used as the reference category. Incidence rates (IR per 100,000 person-years) were calculated across the quintiles. Poisson regression analysis was used to calculate the effect of temperature parameters on stroke incidence. There were 2,405 first-ever strokes (1,294 men), including 1,625 ischemic, 545 cerebral hemorrhages, 213 subarachnoid hemorrhages, and 22 unclassified strokes. The stroke IR was higher in the middle quintile of average temperature, 357.3 (328.4-388.8), and for other parameters. After adjustment for age and sex, for all stroke, the incidence rate ratio (IRR) in the highest (Q5: IRR 0.81, 95% confidence interval (CI) 0.71-0.92) and the second-highest (Q4: IRR 0.80, 95% CI 0.71-0.91) quintile was lower than that in the middle quintile (Q3: Reference). Analogous results were observed for the minimum, maximum, and lag-days temperatures, also in the subtypes and across ≥65 years of age, also in females. CONCLUSIONS: Higher temperatures, irrespective of the parameter (average, minimum, or maximum), had a protective effect against stroke occurrence in Japan.
  • Hideki Nagata, Katsuyuki Miura, Sachiko Tanaka, Aya Kadota, Takehito Hayakawa, Keiko Kondo, Akira Fujiyoshi, Naoyuki Takashima, Yoshikuni Kita, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
    Journal of epidemiology 2021年07月 研究論文(学術雑誌) 
    BACKGROUND: Basic and instrumental activities of daily living (BADL, IADL) are known predictors of mortality. However, the relationship between higher-level functional capacity (HLFC) and mortality and related sex differences have rarely been investigated. METHODS: A prospective population-based cohort study was conducted in 1,824 older residents (≥65 years) with independent BADL from 300 randomly selected areas in Japan from 1995, and the participants were followed up until 2010. Using the Cox proportional hazards model, the relationship between HLFC and mortality risk was investigated with adjustment for possible confounders. HLFC was assessed using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Baseline data were collected using a questionnaire or by home-visit interviews. RESULTS: During an average 12.2-year follow-up, all-cause death was observed in 836 (45.8%) participants. Impaired HLFC was significantly associated with mortality (hazard ratio [HR] 1.37; 95% confidence interval [CI], 1.13-1.65). Lower social role was significantly associated with higher mortality risk in men (HR 1.38; 95% CI, 1.13-1.68). Lower IADL and intellectual activity were significantly associated with higher mortality risk in women (HR 1.50; 95% CI, 1.15-1.95; HR 1.46; 95% CI, 1.19-1.79). The relationship between HLFC and mortality risk showed a similar tendency among cardiovascular diseases, stroke, cancer, and pneumonia. CONCLUSION: Impaired HLFC was associated with a high risk of all-cause mortality among community-dwelling older people with independent BADL. In particular, social role in men and IADL and intellectual activity in women were associated with long-term mortality risk.
  • Teruhide Koyama, Etsuko Ozaki, Nagato Kuriyama, Satomi Tomida, Tamami Yoshida, Ritei Uehara, Keitaro Tanaka, Megumi Hara, Asahi Hishida, Rieko Okada, Yoko Kubo, Isao Oze, Yuriko N Koyanagi, Haruo Mikami, Yohko Nakamura, Ippei Shimoshikiryo, Toshiro Takezaki, Sadao Suzuki, Takahiro Otani, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Kenji Wakai
    Journal of the American Heart Association 10 13 e018293  2021年07月 研究論文(学術雑誌) 
    Background This study aimed to determine the association between sedentary time and mortality with regard to leisure-time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. Methods and Results Using data from the J-MICC (Japan Multi-Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all-cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2-hour increments in exposure) according to the self-reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow-up. The corresponding HRs for each 2-hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114-1.194), 1.125 (95% CI, 1.074-1.179), 1.202 (95% CI, 1.129-1.279), 1.176 (95% CI, 1.087-1.273), and 1.272 (95% CI, 1.159-1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162-1.728) independently of leisure-time metabolic equivalents. Conclusions The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure-time physical activity in a large Japanese population.
  • Thien Vu, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Maryam Zaid, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Yoshihisa Nakagawa, Tomoaki Suzuki, Tohru Asai, Katsuyuki Miura, Hirotsugu Ueshima
    Circulation journal : official journal of the Japanese Circulation Society 85 7 1076 - 1082 2021年06月 研究論文(学術雑誌) 
    BACKGROUND: Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC. CONCLUSIONS: The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.
  • Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura
    Journal of hypertension 39 10 2030 - 2039 2021年06月 研究論文(学術雑誌) 
    OBJECTIVE: Hypertension and intracranial artery stenosis (ICAS) are closely related; however, few studies have compared the strength of the relationship between strictly measured office and out-of-office blood pressure (BP) measurements. The relationship of day-by-day or short-term variability in BP to asymptomatic ICAS also remains unclear. METHODS: In apparently healthy 677 men (mean age, 70 years) from a population-based cohort, we examined the association of strictly measured office BP and 7-day home BP with ICAS on magnetic resonance angiography. We conducted 24-h ambulatory BP monitoring in 468 of the men. Variability indices included day-by-day, daytime, and night-time variability, nocturnal decline, and morning pressor surge. Any ICAS was defined as either mild (1-49%) or severe (≥50%) stenosis. RESULTS: We observed mild and severe ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable-adjusted Poisson regression with robust error variance, higher SBP in office, home, or ambulatory BP monitoring was associated with the presence of any or severe ICAS. The associations with ICAS were comparable between office, home, and ambulatory SBP (all heterogeneity P values >0.1). Independent of mean SBP, greater nocturnal decline or morning pressor surge, but not day-by-day, daytime, or night-time variability, in SBP was associated with higher burden of any or severe ICAS. CONCLUSION: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden.
  • Aya Kadota
    Journal of atherosclerosis and thrombosis 28 12 1260 - 1262 2021年06月 研究論文(学術雑誌)
  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA
    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ
    日本腎臓学会誌 63 4 478 - 478 (一社)日本腎臓学会 2021年06月
  • 顕性アルブミン尿を伴わない糖尿病・非糖尿病におけるeGFR低下リスク要因の探索:滋賀動脈硬化疫学研究SESSA
    久米 真司, 宮澤 伊都子, 門田 文, 久松 隆史, 近藤 慶子, 瀬川 裕佳, 鳥居 さゆき, 荒木 信一, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グル-プ
    日本腎臓学会誌 63 4 478 - 478 (一社)日本腎臓学会 2021年06月
  • Takashi Hisamatsu, Takayoshi Ohkubo, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura
    Circulation 143 Suppl_1 2021年05月 研究論文(学術雑誌) 
    Background: Few studies have compared accurately measured office, self-measured home, and ambulatory blood pressure (BP) for asymptomatic intracranial artery stenosis (ICAS). Relationship of day-by-day or short-term variability in BP to asymptomatic ICAS remains unclear. Objectives: To examine the association of office, home (mean value and day-by-day variability), and ambulatory BP indices (24-hour/daytime/nighttime mean values, short-term variability, nocturnal decline, and morning pressor surge) with asymptomatic ICAS. Methods: Data on office and 7-day home BP and magnetic resonance angiography to assess ICAS were obtained in 677 men (mean age, 70.0 years) from a population-based cohort. Among them, 468 underwent 24-hour ambulatory BP monitoring. Mild- or severe-ICAS was defined as 1-49% or ≥50% stenosis, respectively, and any-ICAS as either mild or severe-ICAS. Results: We observed mild- and severe-ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable Poisson regression with robust error variance, higher systolic BP at office, home, or ambulatory BP monitoring was associated with the presence of any- or severe-ICAS. The associations with ICAS were comparable between office, home, and ambulatory systolic BP (all heterogeneity Ps >0.1). Independent of mean systolic BP, greater nocturnal decline or morning pressor surge in systolic BP was associated with higher burden of any- or severe-ICAS. Conclusion: The magnitude of association of BP accurately measured at office for asymptomatic ICAS was comparable with that of BP at home or ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring may be considered when assessing ICAS in apparently healthy individuals.
  • Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Keiko Kondo, Aya Kadota, Nagako Okuda, Takayoshi Ohkubo, Naomi Miyamatsu, Tomonori Okamura, Katsuyuki Miura, Akira Okayama
    Circulation journal : official journal of the Japanese Circulation Society 85 6 908 - 913 2021年05月 研究論文(学術雑誌) 
    BACKGROUND: This study assessed sex-specific time-associated changes in the impact of risk factors on coronary artery disease (CAD) mortality in a general population over long-term follow-up.Methods and Results:A prospective longitudinal cohort study was conducted on representative Japanese populations followed up for 29 years. Data from 8,396 participants (3,745 men, 4,651 women) were analyzed. The sex-specific multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of 4 risk factors (smoking, diabetes, serum total cholesterol [TC], and systolic blood pressure [SBP]) for CAD mortality were calculated at baseline and at 10, 15, 20, 25, and 29 years of follow-up. In men, smoking (HR 3.23; 95% CI 1.16-9.02) and a 1-SD increase in TC (HR 1.82; 95% CI 1.29-2.57) were strongly associated with a higher risk of CAD in the first 10 years, but this association decreased over time. Diabetes (HR 2.30; 95% CI 1.37-3.85) and a 1-SD increase in SBP (HR 1.23; 95% CI 1.00-1.50) were strongly correlated with a higher risk of CAD after 29 years). In women, diabetes was correlated with CAD after 20 years (HR 2.53; 95% CI 1.19-5.36) and this correlation persisted until after 29 years (HR 2.47; 95% CI 1.40-4.35). CONCLUSIONS: The duration of follow-up needed for the accurate assessment of risk factors for CAD mortality varies according to risk factor and sex.
  • Yuka Sumimoto, Masahiko Yanagita, Naomi Miyamatsu, Nagako Okuda, Nobuo Nishi, Yosikazu Nakamura, Koshi Nakamura, Naoko Miyagawa, Motohiko Miyachi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
    Environmental health and preventive medicine 26 1 57 - 57 2021年05月 研究論文(学術雑誌) 
    BACKGROUND: It has been pointed out that prolonged television (TV) viewing is one of the sedentary behaviors that is harmful to health; however, the association between socioeconomic status (SES) and prolonged TV viewing time has not been sufficiently investigated in Japan. METHODS: The study population are the participants of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey 2010 in Japan. They were residents in 300 randomly selected areas across Japan. This study included 2752 adults. SES was classified according to the employment status, educational attainment, living status, and equivalent household expenditure (EHE). Prolonged TV viewing time was defined as more than or equal to 4 h of TV viewing per day. Multivariable logistic regression analyses were conducted to examine the association of SES with prolonged TV viewing time. RESULTS: The mean TV viewing time was 2.92 h in all participants. Of 2752 participants, 809 (29.4%) prolonged TV viewing, and the mean TV viewing time of them was 5.61 h. The mean TV viewing time in participants without prolonged TV viewing time was 1.81 h. The mean TV viewing time was prolonged as age classes increased and significantly longer in aged ≥60 years. Prolonged TV viewing time was associated with not working for all age classes and sexes. Only among women, education attainment and living status were also associated with prolonged TV viewing time. For education attainment, the lower the received years of education, the higher odds ratios (OR) of prolonged TV viewing time. For living status, in women aged <60 years, living with others had a significantly higher OR compared to living with spouse. On the other hand, in women aged ≥60 years, living alone had a significantly higher OR. EHE did not have any significant associations with prolonged TV viewing time. CONCLUSIONS: In a general Japanese population, it should be noted that the association between SES and prolonged TV viewing time differed by age and sex. Particularly, it must draw attention to the prolonged TV viewing in elderly. The intervention in order to shorten TV viewing time needs to consider these attributes.
  • 尾島 俊之, 中村 美詠子, 西 信雄, 門田 文, 佐田 みずき, 近藤 慶子, 北岡 かおり, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 西 信雄, 北岡 かおり, 近藤 慶子, 門田 文, 中村 美詠子, 佐田 みずき, 尾島 俊之, 岡村 智教, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 173 - 173 (一社)日本循環器病予防学会 2021年05月
  • 佐田 みずき, 岡村 智教, 西 信雄, 門田 文, 中村 美詠子, 近藤 慶子, 北岡 かおり, 尾島 俊之, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 中村 美詠子, 尾島 俊之, 西 信雄, 門田 文, 佐田 みずき, 近藤 慶子, 北岡 かおり, 岡村 智教, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 北岡 かおり, 門田 文, 岡見 雪子, 近藤 慶子, 中村 美詠子, 尾島 俊之, 岡村 智教, 由田 克士, 西 信雄, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 西 信雄, 北岡 かおり, 近藤 慶子, 門田 文, 中村 美詠子, 佐田 みずき, 尾島 俊之, 岡村 智教, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 173 - 173 (一社)日本循環器病予防学会 2021年05月
  • 北岡 かおり, 門田 文, 岡見 雪子, 近藤 慶子, 中村 美詠子, 尾島 俊之, 岡村 智教, 由田 克士, 西 信雄, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 佐田 みずき, 岡村 智教, 西 信雄, 門田 文, 中村 美詠子, 近藤 慶子, 北岡 かおり, 尾島 俊之, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 中村 美詠子, 尾島 俊之, 西 信雄, 門田 文, 佐田 みずき, 近藤 慶子, 北岡 かおり, 岡村 智教, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • 尾島 俊之, 中村 美詠子, 西 信雄, 門田 文, 佐田 みずき, 近藤 慶子, 北岡 かおり, 由田 克士, 三浦 克之
    日本循環器病予防学会誌 56 2 174 - 174 (一社)日本循環器病予防学会 2021年05月
  • Factors of Premature Atrial Contractions among General Japanese Men(和訳中)
    Ahmed Sabrina, Miura Katsuyuki, Hisamatsu Takashi, Kadota Aya, Fujiyoshi Akira, Segawa Hiroyoshi, Torii Sayuki, Takashima Naoyuki, Kondo Keiko, Nakagawa Yoshihisa, Ueshima Hirotsugu
    日本循環器学会学術集会抄録集 85回 OE083 - 1 2021年03月
  • Taro Suzuki, Yasuyuki Nakamura, Yukio Doi, Akira Narita, Atsushi Shimizu, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Aya Kadota, Katsuyuki Miura, Masahiro Nakatochi, Keitaro Tanaka, Megumi Hara, Hiroaki Ikezaki, Masayuki Murata, Toshiro Takezaki, Daisaku Nishimoto, Keitaro Matsuo, Isao Oze, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Miki Watanabe, Sadao Suzuki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai
    The British journal of nutrition 126 12 1 - 9 2021年02月 研究論文(学術雑誌) 
    Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analysed GWAS data on confection consumption using 14 073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative FFQ to estimate food intake that was validated previously. Association of the imputed variants with confection consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1-3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/d) in addition to the above-described variables. We found 418 SNP located in 12q24 that were associated with confection consumption. SNP with the ten lowest P-values were located on nine genes including at the BRAP, ACAD10 and aldehyde dehydrogenase 2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with confections intake with genome-wide significance. In conclusion, we found a significant number of SNP located on 12q24 genes that were associated with confections intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.
  • Maryam Zaid, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Sayaka Kadowaki, Atsushi Satoh, Akira Sekikawa, Emma Barinas-Mitchell, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of atherosclerosis and thrombosis 29 2 282 - 295 2021年02月 研究論文(学術雑誌) 
    AIMS: The utility of carotid intima-media thickness (cIMT) as a marker for coronary heart disease is under heavy debate. This is predominantly due to the lack of a standard definition of cIMT, leading to inconsistent results. We investigated and compared the relationships of five different measures of cIMT with coronary calcium. METHODS: Japanese men aged 40-79y (n=869) from Shiga Epidemiological Study of Subclinical Atherosclerosis were examined. Mean cIMT was measured in three segments of the carotid arteries: common carotid artery (CCAmean), internal carotid artery (ICAmean) and bifurcation (Bifmean). Mean cIMT of average values (Mean cIMT) and mean cIMT of maximum values (Mean-Max cIMT) of all segments combined were assessed. Coronary calcium was assessed as coronary artery calcification (CAC). Ordinal logistic regression was used to determine the odds ratio (OR) of higher CAC per 1 standard deviation higher cIMT measure. Analyses were adjusted for cardiovascular covariates and stratified by age quartiles. RESULTS: All cIMT measures had positive associations with CAC (p<0.001): [OR, 95% Confidence Interval]: ICAmean [1.23, 1.07-1.42], CCAmean [1.27, 1.08-1.49], Bifmean [1.33, 1.15-1.53], Mean cIMT [1.42, 1.22-1.66], and Mean-Max [1.50, 1.28-1.75]. In age-stratified analyses, only Mean-Max cIMT maintained a significant relationship with CAC in every age quartile (p<0.05), while CCAmean had some of the weakest associations among age quartiles. CONCLUSIONS: Mean-Max cIMT had consistently stronger associations with coronary calcium, independent of important confounders, such as age. The most oft-used measure, CCAmean, was no longer associated with coronary calcium after age-adjustment and stratification.
  • Ali Haidar Syaifullah, Akihiko Shiino, Akira Fujiyoshi, Aya Kadota, Keiko Kondo, Takahiro Ito, Hiroyoshi Segawa, Mohammad Moniruzzaman, Takashi Waki, Naoko Miyagawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura, Hirotsugu Ueshima, Katsuyuki Miura
    Alcohol (Fayetteville, N.Y.) 90 57 - 65 2021年02月 研究論文(学術雑誌) 
    The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40-79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010-2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases.
  • Asahi Hishida, Masahiro Nakatochi, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Mineko Tsukamoto, Yuka Kadomatsu, Sadao Suzuki, Takeshi Nishiyama, Nagato Kuriyama, Isao Watanabe, Toshiro Takezaki, Daisaku Nishimoto, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Haruo Mikami, Miho Kusakabe, Isao Oze, Yuriko N Koyanagi, Yasuyuki Nakamura, Aya Kadota, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Michiaki Kubo, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai
    Nagoya journal of medical science 83 1 183 - 194 2021年02月 研究論文(学術雑誌) 
    Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study, we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10-8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10-6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.
  • Ebtehal Salman, Aya Kadota, Takashi Hisamatsu, Hiroyoshi Segawa, Sayuki Torii, Akira Fujiyoshi, Keiko Kondo, Yoshiyuki Watanabe, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura, For The Sessa Research Group
    Journal of atherosclerosis and thrombosis 29 2 174 - 187 2021年01月 研究論文(学術雑誌) 
    AIM: The relationship of blood pressure (BP) indexes (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], mean arterial pressure [MAP]) to subclinical cerebrovascular diseases (SCVDs) remains unclear. This study aimed to elucidate the relationship of four BP indexes measured at two visits on SCVDs assessed by magnetic resonance imaging (MRI) in general Japanese men. METHODS: In general Japanese men aged 40-79 years (N=616), office BP indexes were measured at two visits (Visits 1 [2006-2008] and 2 [2010-2014]). MRI images obtained on the third visit (2012-2015) were examined for prevalent SCVDs: lacunar infarction, periventricular hyperintensity (PVH), deep subcortical white matter hyperintensity (DSWMH), microbleeds, and intracranial artery stenosis (ICAS). Using a multivariable logistic regression analysis, we computed and estimated the odds ratio of each prevalent SCVD for one standard deviation higher BP indexes. The same analyses were performed using home BP. RESULTS: All four office BP indexes at both visits associated with lacunar infarction. Visit 1 and 2 DBP and Visit 1 MAP associated with PVH and DSWMH, and Visit 1 SBP associated with DSWMH. All Visit 2 BP indexes appear to show stronger association with microbleeds than Visit 1 indexes, and Visit 1 and 2 SBP, PP, and MAP showed similar associations with ICAS. Additional analyses using home BP indexes revealed similar relationships; however, the significance of some relationships decreased. CONCLUSION: In general Japanese men, BP indexes were associated with most of SCVDs, and BP indexes measured at different periods associated with different SCVDs assessed by MRI.
  • Aya Hirata, Tomonori Okamura, Takumi Hirata, Daisuke Sugiyama, Takayoshi Ohkubo, Nagako Okuda, Yoshikuni Kita, Takehito Hayakawa, Aya Kadota, Keiko Kondo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    Journal of epidemiology 2021年01月 研究論文(学術雑誌) 
    BackgroundNon-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.MethodsA total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60-89 mg/dL, 90-119 mg/dL, 120-149 mg/dL, 150-179 mg/dL, 180-209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.ResultsDuring the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150-179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR=1.56, 95% CI, 1.01-2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.ConclusionIn a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.
  • Mohammad Moniruzzaman, Aya Kadota, Akihiko Shiino, Akira Fujiyoshi, Takahiro Ito, Ali Haidar Syaifullah, Naoko Miyagawa, Keiko Kondo, Takashi Hisamatsu, Hiroyoshi Segawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura
    Journal of physical activity & health 18 2 157 - 164 2021年01月 研究論文(学術雑誌) 
    BACKGROUND: To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. METHODS: The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis-a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006-2008) and BVs at follow-up (2012-2015) for age-stratified groups (<60 y and ≥60 y). RESULTS: In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). CONCLUSIONS: The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.
  • 日本人女性の妊娠出産歴と高血圧の関連 J-MICCベースライン分析
    大橋 瑞紀, 三浦 克之, 高嶋 直敬, 門田 文, 斎藤 祥乃, 辻 俊一郎, 村上 節, 喜多 義邦, 若井 建志
    Journal of Epidemiology 31 Suppl. 119 - 119 (一社)日本疫学会 2021年01月
  • Yasuyuki Nakamura, Akira Narita, Yoichi Sutoh, Nahomi Imaeda, Chiho Goto, Kenji Matsui, Naoyuki Takashima, Aya Kadota, Katsuyuki Miura, Masahiro Nakatochi, Takashi Tamura, Asahi Hishida, Ryoko Nakashima, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Toshiro Takezaki, Rie Ibusuki, Isao Oze, Hidemi Ito, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Miho Kusakabe, Hiroko Nakagawa-Senda, Sadao Suzuki, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Yoshikuni Kita, Kenji Wakai
    Journal of nutritional science 10 e61  2021年 研究論文(学術雑誌) 
    Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population. We analysed GWAS data using 14 076 participants from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with total meat consumption per 1000 kcal energy was performed by linear regression analysis with adjustments for age, sex, and principal component analysis components 1-10. We found that no genetic variant, including rs671, was associated with meat consumption. The previously reported single nucleotide polymorphisms that were associated with meat consumption in samples of European ancestry could not be replicated in our J-MICC data. In conclusion, significant genetic factors that affect meat consumption were not observed in a Japanese population.
  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連 滋賀動脈硬化疫学研究
    久松 隆史, 大久保 孝義, 藤吉 朗, 鳥居 さゆ希, 瀬川 裕佳, 近藤 慶子, 門田 文, 高嶋 直敬, 設楽 智史, 有馬 久富, 中川 義久, 渡邉 嘉之, 椎野 顯彦, 野崎 和彦, 上島 弘嗣, 三浦 克之
    Journal of Epidemiology 31 Suppl. 89 - 89 (一社)日本疫学会 2021年01月
  • 日本人女性の妊娠出産歴と高血圧の関連 J-MICCベースライン分析
    大橋 瑞紀, 三浦 克之, 高嶋 直敬, 門田 文, 斎藤 祥乃, 辻 俊一郎, 村上 節, 喜多 義邦, 若井 建志
    Journal of Epidemiology 31 Suppl. 119 - 119 (一社)日本疫学会 2021年01月
  • 診察室・家庭・24時間自由行動下血圧および血圧変動と無症候性脳動脈狭窄との関連 滋賀動脈硬化疫学研究
    久松 隆史, 大久保 孝義, 藤吉 朗, 鳥居 さゆ希, 瀬川 裕佳, 近藤 慶子, 門田 文, 高嶋 直敬, 設楽 智史, 有馬 久富, 中川 義久, 渡邉 嘉之, 椎野 顯彦, 野崎 和彦, 上島 弘嗣, 三浦 克之
    Journal of Epidemiology 31 Suppl. 89 - 89 (一社)日本疫学会 2021年01月
  • Sayaka Kadowaki, Takashi Kadowaki, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka, Sayuki Torii, Keiko Kondo, Aya Kadota, Kamal Masaki, Tomonori Okamura, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima
    Hypertension research : official journal of the Japanese Society of Hypertension 44 1 80 - 87 2021年01月 研究論文(学術雑誌) 
    Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40-79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.
  • Yuka Sumimoto, Masahiko Yanagita, Naomi Miyamatsu, Nagako Okuda, Nobuo Nishi, Yosikazu Nakamura, Koshi Nakamura, Naoko Miyagawa, Motohiko Miyachi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
    PloS one 16 7 e0254706  2021年 研究論文(学術雑誌) 
    BACKGROUND: Lower socioeconomic status (SES) may be related to inactivity lifestyle; however, the association between SES and physical inactivity has not been sufficiently investigated in Japan. METHODS: The study population is the participants of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey 2010 in Japan. They were residents in 300 randomly selected areas across Japan. This study included 2,609 adults. Physical activity was assessed by physical activity index (PAI) calculated from activity intensity and time. The lowest tertile of PAI for each 10-year age class and sex was defined as physical inactivity. Multivariable logistic regression analyses were conducted to examine the association of SES (employment status, educational attainment, living status, and equivalent household expenditure (EHE)) with physical inactivity. RESULTS: In the distribution of PAI by age classes and sex, the highest median PAI was aged 30-39 years among men (median 38.6), aged 40-49 years among women (38.0), and median PAI was decreased with increasing age. Multivariable-adjusted model shows that not working was significantly associated with physical inactivity after adjustment for age in all age groups and sexes. Not living with spouse for adult women and elderly men was significantly associated with physical inactivity compared to those who living with spouse. However, neither educational attainment nor EHE had any significant associations with physical inactivity. CONCLUSIONS: The result indicated that physical inactivity was associated with SES in a general Japanese population. SES of individuals need to be considered in order to prevent inactivity lifestyle.
  • Kaori Umemoto, Sachimi Kubo, Yoko Nishida, Aya Higashiyama, Kuniko Kawamura, Yoshimi Kubota, Takumi Hirata, Aya Hirata, Mizuki Sata, Kazuyo Kuwabara, Junji Miyazaki, Aya Kadota, Miho Iida, Daisuke Sugiyama, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    Journal of atherosclerosis and thrombosis 29 2 188 - 199 2020年12月 研究論文(学術雑誌) 
    AIM: This study investigated the relationship between birth physique and cardiovascular risk factors in Japanese urban residents aged 40 years and more. METHODS: A self-administered questionnaire on birth physique was performed among 624 individuals (165 men and 459 women) who participated in the KOBE study. We examined whether self-reported birth physique and available recorded birth weights matched for 72 participants. Then the association between birth physique and risk factors for all participants was examined by gender. Body size at birth in the questionnaire (large, medium, small) was set as an exposure and laboratory values from the baseline survey (2010-2011) were used as outcomes. RESULTS: Mean (standard deviation) recorded birth weight of 72 participants was 3665 (318), 3051 (300), and 2653 (199) g, in the large, medium, and small group, respectively. In the analysis for all participants, odds ratio for having both hypertension and impaired glucose tolerance were significantly higher in the small versus large birth weight group, which was 7.42 (95% CI 1.75-31.50) for men and 4.44 (95% CI 1.14-17.30) for women after adjusting for age, body mass index, smoking/alcohol/exercise habits, and menstrual status in women. Similar results were observed in participants with recorded birth weight. CONCLUSIONS: The present study indicates that individuals with small physique at birth might be at higher risk for hypertension and impaired glucose tolerance in middle age compared to those with large birth weight.
  • Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Daisuke Matsui, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Asahi Hishida, Tae Sasakabe, Sayo Kawai, Mariko Naito, Naoyuki Takashima, Aya Kadota, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Hiroko Nakagawa-Senda, Toshiro Takezaki, Ippei Shimoshikiryo, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kiyonori Kuriki, Kokichi Arisawa, Hirokazu Uemura, Kenji Takeuchi, Kenji Wakai
    Scientific Reports 10 1 2020年12月 研究論文(学術雑誌) 
    Abstract There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.
  • Mohammad Moniruzzaman, Aya Kadota, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Naoko Miyagawa, Akira Fujiyoshi, Takashi Hisamatsu, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura
    Stroke 51 12 3584 - 3591 2020年12月 研究論文(学術雑誌) 
    BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.
  • Takashi Hisamatsu, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura
    Hypertension research : official journal of the Japanese Society of Hypertension 43 12 1344 - 1351 2020年12月 研究論文(学術雑誌) 
    From the national surveys of Japan over a 55-year period (1961-2016), a steady decrease was observed in systolic blood pressure (BP) levels among all age groups of men and women, but not in diastolic BP levels-particularly among men. Hypertension prevalence remains high: over 60% of men aged ≥50 years and women aged ≥60 years had hypertension in 2016. However, the control rates of hypertension have continuously improved over a 36-year period, and were ~40% in 2016. Nonetheless, the over 50% prevalence of uncontrolled hypertension is a major risk factor for future cardiovascular diseases. Of the estimated 43 million hypertensives in Japan, most (31 million, 72%) were under poor control. According to new Japanese hypertension guidelines (JSH 2019), there will be only a small increase (2.2 million, 2.1 percentage points) in adults who are recommended for antihypertensive medication compared with 2014 guidelines. However, an additional 5.3 million (22.1 percentage points) adults taking antihypertensive medication would have a BP above the target defined by JSH 2019. The number of hypertensives with poor control was targeted to decrease by 7 million-from 31 million in 2017 to 24 million in 2028-when the followings are achieved: (1) the prevalence of hypertension decreases by 5 percentage points; (2) the treatment rate of hypertension among hypertensives increases by 10 percentage points; and (3) the control rate of hypertension, defined as BP <140/90 mmHg, among individuals taking antihypertensive medication increases by 10 percentage points. Both high-risk and population strategies to manage and prevent hypertension deserve greater priority.
  • Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Hiromi Yamauchi, Seiko Ohno, Sachiko Tanaka-Mizuno, Nagako Okuda, Naoko Miyagawa, Hisatomi Arima, Tomonori Okamura, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima, The Nippon Data Research Group
    Nutrients 12 12 2020年11月 研究論文(学術雑誌) 
    The consumption of red meat has been recommended for individuals with reduced kidney function. However, red meat intake was recently suspected to increase cardiovascular disease (CVD) risk. We evaluated the association of red meat intake with CVD mortality risk in Japanese with/without reduced kidney function. Overall, 9112 participants of a Japanese national survey in 1980, aged ≥30 years, were followed for 29 years. Red meat intake was assessed using weighed dietary record. Cox proportional hazards models were used to estimate the hazard ratio (HR) of CVD mortality according to sex-specific tertiles of red meat intake. We also performed stratified analyses with/without reduced kidney function defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m2. Red meat intake was not associated with CVD mortality risk in men and women. In stratified analyses, the HR of the highest compared with the lowest tertile of red meat intake was lower only in women with reduced kidney function (0.67, 95% confidence interval 0.46-0.98). In conclusion, there were no clear associations between red meat intake and CVD mortality risk in Japanese population; however, a higher intake of red meat was associated with lower risk of future CVD mortality in women with reduced kidney function.
  • 岡見 雪子, 中村 保幸, 三浦 克之, 宮松 直美, 岡村 智教, 近藤 慶子, 門田 文, 大久保 孝義, 岡山 明, 上島 弘嗣
    日本循環器病予防学会誌 55 3 223 - 223 (一社)日本循環器病予防学会 2020年11月
  • 栗原 綾子, 岡村 智教, 杉山 大典, 奥田 奈賀子, 大久保 孝義, 岡山 明, 宮川 尚子, 門田 文, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 55 3 228 - 228 (一社)日本循環器病予防学会 2020年11月
  • 腎症 18年間の糖尿病診療および糖尿病合併症検査実施率の推移 滋賀県医師会糖尿病実態調査における診療所と病院の比較
    宮澤 伊都子, 前川 聡, 門田 文, 三浦 克之, 中村 隆志, 小西 眞, 越智 眞一, 岡本 元純
    糖尿病合併症 34 Suppl.1 204 - 204 (一社)日本糖尿病合併症学会 2020年11月
  • 北岡 かおり, 三浦 克之, 門田 文, 近藤 慶子, 岡見 雪子, 田中 佐智子, 高嶋 直敬, 中村 保幸, 喜多 義邦, 若井 建志
    日本循環器病予防学会誌 55 3 222 - 222 (一社)日本循環器病予防学会 2020年11月
  • 栗原 綾子, 岡村 智教, 杉山 大典, 奥田 奈賀子, 大久保 孝義, 岡山 明, 宮川 尚子, 門田 文, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 55 3 228 - 228 (一社)日本循環器病予防学会 2020年11月
  • 北岡 かおり, 三浦 克之, 門田 文, 近藤 慶子, 岡見 雪子, 田中 佐智子, 高嶋 直敬, 中村 保幸, 喜多 義邦, 若井 建志
    日本循環器病予防学会誌 55 3 222 - 222 (一社)日本循環器病予防学会 2020年11月
  • 岡見 雪子, 中村 保幸, 三浦 克之, 宮松 直美, 岡村 智教, 近藤 慶子, 門田 文, 大久保 孝義, 岡山 明, 上島 弘嗣
    日本循環器病予防学会誌 55 3 223 - 223 (一社)日本循環器病予防学会 2020年11月
  • Aya Hirata, Akemi Kakino, Tomonori Okamura, Yoko Usami, Yoshiko Fujita, Aya Kadota, Akira Fujiyoshi, Takashi Hisamatsu, Keiko Kondo, Hiroyoshi Segawa, Tatsuya Sawamura, Katsuyuki Miura, Hirotsugu Ueshima
    Atherosclerosis 313 20 - 25 2020年11月 研究論文(学術雑誌) 
    BACKGROUND AND AIMS: Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC). METHODS: We selected 910 community-dwelling Japanese men aged 40-79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years). RESULTS: The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96-1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged <65 and ≥ 65 years, respectively. CONCLUSIONS: The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted.
  • Yuko Takatsuji, Aya Ishiguro, Kei Asayama, Takayoshi Ohkubo, Katsuyuki Miura, Aya Kadota, Masahiko Yanagita, Akira Fujiyoshi, Hisatomi Arima, Naoko Miyagawa, Naoyuki Takashima, Yoshikuni Kita, Takehito Hayakawa, Masahiro Kikuya, Yasuyuki Nakamura, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
    The Tohoku journal of experimental medicine 252 3 253 - 262 2020年11月 研究論文(学術雑誌) 
    Exercise habits are known as a protective factor for a variety of diseases and thus recommended worldwide; however, few studies have examined long-term effects of exercise habits on mortality. We continuously monitored death status in a nationwide population sample of 7,709 eligible persons from the National Integrated Project for Prospective Observation of Noncommunicable Disease and its Trends in the Aged in 1990 (NIPPON DATA90), for which baseline data were obtained in 1990. To investigate the long-term impact of baseline exercise habits, we calculated the relative risk of non-exercisers (participants without regular voluntary exercise habits) in reference to exercisers (those with these habits) for all-cause or cause-specific mortality using a Cox proportional hazard model, in which the following confounding factors were appropriately adjusted: sex, age, body mass index, total energy intake, smoking, drinking, and history of cardiovascular disease. During a median 20 years of follow-up, 1,747 participants died, 99 of heart failure. The risk for all-cause mortality was 12% higher in non-exercisers than in exercisers (95% confidence interval, 1%-24%), which was also observed for mortality from heart failure, as 68% higher in non-exercisers than in exercises (95% confidence interval, 3%-173%). These associations were similarly observed when the participants were divided to subgroups by sex, age, and the light, moderate, or vigorous intensity of physical activity, without any significant heterogeneities (P > 0.1). The present study has revealed significant impact of exercise habits on long-term mortality risks, supporting worldwide recommendations for improvement of exercise habits.
  • Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Keiko Kondo, Yoshikuni Kita, Takehito Hayakawa, Hideyuki Kanda, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima
    Journal of hypertension 38 11 2230 - 2236 2020年11月 研究論文(学術雑誌) 
    OBJECTIVE: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years. METHODS: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39.4 years; 55.4% women) without clinical CVD or antihypertensive medication. Participants were classified as follows: normal blood pressure (BP) (SBP/DBP, <120/<80 mmHg), high-normal BP (120-129/<80 mmHg), elevated BP (130-139/80-89 mmHg), ISH, isolated diastolic hypertension (IDH) (<140/≥90 mmHg), and systolic--diastolic hypertension (SDH) (≥140/≥90 mmHg). RESULTS: ISH was observed in 389 (8.1%) participants. During the 29-year follow-up, 115 participants died of CVD, 28 of coronary heart disease, and 49 of stroke. Cox proportional hazards models adjusted for demographics and CVD risk factors showed that participants with ISH had higher risk of CVD mortality than those with normal BP [hazard ratio (confidence interval), 4.10 (1.87-9.03)]. The magnitude of CVD mortality risk related to ISH was comparable with that related to IDH [3.38 (1.31-8.72)] and not as great as that related to SDH [5.41 (2.63-11.14)]. We found significant associations of ISH with coronary and stroke mortality. The association of ISH with CVD mortality was consistent across men and women and those aged 30-39 and 40-49 years. CONCLUSION: ISH among young-to-middle-aged Japanese adults was independently associated with higher risk of CVD mortality later in life.
  • Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Satomi Tomida, Ritei Uehara, Yuichiro Nishida, Chisato Shimanoe, Asahi Hishida, Takashi Tamura, Mineko Tsukamoto, Yuka Kadomatsu, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Rie Ibusuki, Toshiro Takezaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Hirokazu Uemura, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Kenji Wakai
    Journal of Atherosclerosis and Thrombosis 27 10 1097 - 1107 2020年10月 研究論文(学術雑誌)
  • Chikako Nakama, Takashi Kadowaki, Jina Choo, Aiman El-Saed, Aya Kadota, Bradley J. Willcox, Akira Fujiyoshi, Chol Shin, Joseph K. Leader, Katsuyuki Miura, Kamal Masaki, Hirotsugu Ueshima, Lewis H. Kuller, Jessica Bon, Akira Sekikawa
    IJC Heart & Vasculature 30 100618 - 100618 2020年10月 研究論文(学術雑誌)
  • Tai Pham, Akira Fujiyoshi, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Ayako Kunimura, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
    International journal of cardiology 314 89 - 94 2020年09月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND AND AIMS: To examine whether smoking habits, including smoking amount and cessation duration at baseline, are associated with atherosclerosis progression. METHODS: At baseline (2006-08, Japan), we obtained smoking status, amount of smoking and time since cessation for quitters in a community-based random sample of Japanese men initially aged 40-79 years and free of cardiovascular disease. Coronary artery calcification (CAC) and aortic artery calcification (AAC) as biomarker of atherosclerosis was quantified using Agatston's method at baseline and after 5 years of follow-up. We defined progression of CAC and AAC (yes/no) using modified criteria by Berry. RESULTS: A total of 781 participants was analyzed. Multivariable adjusted odds ratios (ORs) of CAC and AAC progression for current smokers were 1.73 (95% CI, 1.09-2.73) and 2.47 (1.38-4.44), respectively, as compared to never smokers. In dose-response analyses, we observed a graded positive relationship of smoking amount and CAC progression in current smokers (multivariable adjusted ORs: 1.23, 1.72, and 2.42 from the lowest to the highest tertile of pack-years). Among the former smokers, earlier quitters (≥10.7 years) had similar ORs of the progression of CAC and AAC to that of participants who had never smoked. CONCLUSIONS: Compared with never smokers, current smokers especially those with greater pack-years at baseline had higher risk of atherosclerosis progression in community-dwelling Japanese men. Importantly, the residual adverse effect appears to be present for at least ten years after smoking cessation. The findings highlight the importance of early avoidance or minimizing smoking exposure for the prevention of atherosclerotic disease.
  • Hiroko Hattori, Aya Hirata, Sachimi Kubo, Yoko Nishida, Miki Nozawa, Kuniko Kawamura, Takumi Hirata, Yoshimi Kubota, Mizuki Sata, Kazuyo Kuwabara, Aya Higashiyama, Aya Kadota, Daisuke Sugiyama, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    International journal of environmental research and public health 17 16 2020年08月 研究論文(学術雑誌) 
    The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61-1.51), 1.06 (0.67-1.66), and 1.65 (1.06-2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.
  • 日本人男性における冠動脈の石灰化で判断した潜在性アテローム硬化進行と腎機能との関連 SESSA研究(The association between kidney function and subclinical atherosclerosis progression evaluated by coronary artery calcification in Japanese men: SESSA study)
    Ganbaatar Namuun, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Miyazawa Itsuko, Kondo Keiko, Salman Ebtehal, Segawa Hiroyoshi, Torii Sayuki, Kume Shinji, Hisamatsu Takashi, Araki Shinichi, Maegawa Hiroshi, Ueshima Hirotsugu
    日本腎臓学会誌 62 4 383 - 383 2020年07月
  • 中年期日本人男性におけるApoAI含有LOX-1リガンドの血中レベルと冠動脈石灰化との関連(Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men)
    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣
    日本循環器学会学術集会抄録集 84回 OJ25 - 5 2020年07月
  • Serum Levels of LOX-1 Ligand Containing ApoAI are Associated with Coronary Artery Calcification in Middle-aged Japanese Men(和訳中)
    平田 あや, 垣野 明美, 岡村 智教, 門田 文, 藤吉 朗, 久松 隆史, 沢村 達也, 三浦 克之, 上島 弘嗣
    日本循環器学会学術集会抄録集 84回 OJ25 - 5 2020年07月
  • Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Nguyen Van Tien, Asahi Hishida, Takashi Tamura, Yoko Kubo, Mineko Tsukamoto, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Daisaku Nishimoto, Teruhide Koyama, Etsuko Ozaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Aya Kadota, Naoyuki Takashima, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Kenji Wakai
    Nutrients 12 6 1605 - 1605 2020年05月 研究論文(学術雑誌) 
    The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12–1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.
  • Satoshi Shoji, Shun Kohsaka, Mitsuaki Sawano, Tomonori Okamura, Aya Hirata, Daisuke Sugiyama, Takayoshi Ohkubo, Yasuyuki Nakamura, Makoto Watanabe, Aya Kadota, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
    Journal of atherosclerosis and thrombosis 28 1 34 - 43 2020年03月 [有り][無し]
     研究論文(学術雑誌) 
    AIMS: P-wave terminal force in lead V1 (PTFV1) is an electrocardiogram marker of increased left atrial pressure and may be a noninvasive and early detectable marker for future cardiovascular events in the general population compared to serum B-type natriuretic peptide (BNP) concentration. The clinical significance of PTFV1 in the contemporary general population is an area of unmet need. We aimed to demonstrate the correlation between PTFV1 and BNP concentrations in a contemporary representative Japanese population. METHODS: Among 2,898 adult men and women from 300 randomly selected districts throughout Japan (NIPPON DATA2010), we analyzed 2,556 participants without cardiovascular disease (stroke, myocardial infarction, and atrial fibrillation). Elevated BNP was defined as a value of ≥ 20 pg/mL based on the definition from the Japanese Circulation Society guidelines. RESULTS: In total, 125 (4.9%) participants had PTFV1. Participants with PTFV1 were older with a higher prevalence of hypertension, major electrocardiographic findings, and elevated BNP concentrations (13.5 [6.9, 22.8] versus 7.8 [4.4, 14.5] pg/mL; P<0.001). After adjustment for confounders, PTFV1 was correlated with elevated BNP (odds ratio, 1.66; 95% confidence interval, 1.05-2.62; P=0.030). This correlation was consistent among various subgroups and was particularly evident in those aged <65 years or those without a history of hypertension. CONCLUSIONS: In the contemporary general population cohort, PTFV1 was independently related to high BNP concentration. PTFV1 may be an alternative marker to BNP in identifying individuals at a higher risk of future cardiovascular events in the East Asian population.
  • Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Atsushi Hozawa, Takehito Hayakawa, Nagako Okuda, Naoko Miyagawa, Aya Kadota, Takayoshi Ohkubo, Yoshitaka Murakami, Kiyomi Sakata, Katsuyuki Miura, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
    Journal of epidemiology 31 2 119 - 124 2020年02月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Major reasons for long-term care insurance certification in Japan are stroke, dementia and fracture. These diseases are reported to be associated with calcium intake. This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population. METHODS: A population-based nested case control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examined using conditional logistic regression models. To assess the accuracy of the estimates, we conducted bootstrap analyses. RESULTS: The adjusted odds ratios (ORs) for impaired ADL compared with the group with a calcium intake of <476 mg/day were 0.72 (95% confidence interval, 95% CI: 0.37-1.40) for the 476-606 mg/day group and 0.44 (0.21-0.94) for the ≥607 mg/day group in 2000 (P for linear trend = 0.03). After the bootstrap analyses, the inverse relationship unchanged (median OR per 100-mg rise in calcium intake: 0.87 [1,000 resamplings], 95% CI: 0.76-0.97). CONCLUSIONS: After bootstrap analyses, calcium intake was inversely associated with impaired ADL, 10 years after the baseline survey.
  • Chisato Shimanoe, Tsuyoshi Hachiya, Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Yoichi Sutoh, Atsushi Shimizu, Asahi Hishida, Sayo Kawai, Rieko Okada, Takashi Tamura, Keitaro Matsuo, Hidemi Ito, Etsuko Ozaki, Daisuke Matsui, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Hirokazu Uemura, Sadao Suzuki, Miki Watanabe, Kiyonori Kuriki, Kaori Endoh, Haruo Mikami, Yohko Nakamura, Yukihide Momozawa, Michiaki Kubo, Masahiro Nakatochi, Mariko Naito, Kenji Wakai
    Genes, Brain and Behavior 18 2 2020年02月 [有り][無し]
     研究論文(学術雑誌) 
    Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10-6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10-6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
  • Azusa Shima, Naomi Miyamatsu, Katsuyuki Miura, Naoko Miyagawa, Nagako Okuda, Katsushi Yoshita, Aya Kadota, Harumitsu Suzuki, Keiko Kondo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima
    Hypertension research : official journal of the Japanese Society of Hypertension 43 2 132 - 139 2020年02月 [有り][無し]
     研究論文(学術雑誌) 
    In Asian countries, a major source of salt intake is from seasoning or table salt added at home. However, little is known about the adverse effects of salt intake evaluated according to household unit. We investigated the relationship between household salt intake level and mortality from all-cause and cardiovascular diseases (CVDs). Participants included 8702 individuals (56% women) who were living with someone else and who were aged 30-79 years and enrolled in the National Nutritional Survey of Japan in 1980 with a 24-year follow-up. Household nutrient intake was evaluated using a 3-day weighing record method in which all foods and beverages consumed by any of the household members were recorded. The household salt intake level was defined as the amount of salt consumed (g) per 1000 kcal of total energy intake in each household, and its average was 6.25 (2.02) g/1000 kcal. During the follow-up, there were 2360 deaths (787 CVD, 168 coronary heart disease [CHD], and 361 stroke). Cox proportional hazard ratios (HRs) for an increment of 2 g/1000 kcal in household salt intake were calculated and adjusting for sex, age, body mass index, smoking status, alcohol consumption status, self-reported work exertion level, household potassium intake, household saturated fatty acid intake, and household long-chain n-3 polyunsaturated fatty acid intake. The HRs (95% confidence intervals) were 1.07 (1.02, 1.12) for all-cause mortality, 1.11 (1.03, 1.19) for CVD, 1.25 (1.08, 1.44) for CHD, and 1.12 (1.00, 1.25) for stroke. The household salt intake level was significantly associated with long-term risk of all-cause, CVD, CHD, and stroke mortality in a representative Japanese population.
  • Keiko Fuse, Aya Kadota, Keiko Kondo, Katsutaro Morino, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Itsuko Miyazawa, Satoshi Ugi, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima
    Diabetes research and clinical practice 160 108002 - 108002 2020年02月 [有り][無し]
     
    AIMS: Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM. METHODS: In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models. RESULTS: Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2. CONCLUSIONS: Liver fat accumulation assessed by CT was associated with the incidence of DM.
  • Md Maruf Haque Khan, Akira Fujiyoshi, Akihiko Shiino, Takashi Hisamatsu, Sayuki Torii, Sentaro Suzuki, Ayako Kunimura, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of atherosclerosis and thrombosis 27 9 995 - 1009 2020年01月 [有り][無し]
     研究論文(学術雑誌) 
    AIM: Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. However, few studies have described the association between CAC and SCVDs. Therefore, the aim of this study was to assess the clinical relationship between CAC and SCVDs in a healthy Japanese male population. METHODS: In this observational study, 709 men, free of stroke, were sampled from a city in Japan from 2010 to 2014. CAC was scored using the Agatston method. The following SCVDs were assessed using magnetic resonance imaging: intracranial arterial stenosis (ICAS), lacunar infarction, deep and subcortical white matter hyperintensity (DSWMH), periventricular hyperintensity (PVH), and microbleeds. The participants were categorized according to CAC scores as follows: no CAC (0), mild CAC (1-100), and moderate-to-severe CAC (>100). The adjusted odds ratios of prevalent SCVDs were computed in reference to the no-CAC group using logistic regression. RESULTS: The mean (standard deviation) age of the participants was 68 (8.4) years. Participants in the moderate-to-severe-CAC category showed significantly higher odds of prevalent lacunar infarction, DSWMH, and ICAS in age-adjusted and risk-factor-adjusted models. Microbleeds and PVH, in contrast, did not show any significant associations. The trends for CAC with lacunar infarction, DSWMH, and ICAS were also significant (all P-values for trend ≤ 0.02). CONCLUSIONS: Higher CAC scores were associated with higher odds of lacunar infarction, DSWMH, and ICAS. The presence and degree of CAC may be a useful indicator for SCVDs involving small and large vessels.
  • Ali Tanweer Siddiquee, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Yoshino Saito, Harumitsu Suzuki, Keiko Kondo, Hiromi Yamauchi, Takahiro Ito, Hiroyoshi Segawa, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima
    Alcohol (Fayetteville, N.Y.) 2020年01月 [有り][無し]
     
    Although heavy alcohol consumption has been identified as a risk factor for adverse cognitive functioning, it currently remains unclear whether moderate alcohol consumption exerts similar effects. Observational studies previously reported the potential benefits of moderate alcohol consumption on cognition, particularly in the elderly; however, these effects have not yet been demonstrated in Asian populations. The aim of the present study was to investigate the relationship between alcohol consumption levels and global and domain-specific cognitive functions in cognitively intact elderly Japanese men. Cross-sectional data from the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA), an ongoing prospective, population-based study in Shiga, Japan, were used to examine the relationship between alcohol consumption and cognitive function. Men (n = 585), aged ≥65 years, provided information on their weekly consumption of alcohol and the data obtained were used to construct categories of never, ex- (quit before interview), very light (<14 g/day), light (14 - 23 g/day), moderate (>23 - 46 g/day), and heavy (>46 g/day) drinkers. Cognitive function was measured using the Cognitive Abilities Screening Instrument (CASI). A fractional logistic regression model adjusted for age, education, body mass index, smoking, exercise, hypertension, diabetes, and dyslipidemia showed that the CASI scores for global and domain-specific cognitive functions were not significantly different between all subgroups of current drinkers and never-drinkers. However, the CASI score of ex-drinkers (multivariable adjusted mean CASI score [SD]) was significantly lower than that of never-drinkers in the global (never vs ex: 90.16 [2.21] vs 88.26 [2.58]) and abstraction and judgment domains (never vs ex: 9.48 [0.46] vs 8.61 [0.57]). The present results do not suggest any beneficial or adverse relationship between current alcohol consumption levels and cognitive functioning (both global and domain specific) in elderly Japanese men; however, low cognitive function among ex-drinkers warrants future investigations to identify the factors causing drinkers to quit.
  • Hajime Taya, Kazuyo Kuwabara, Aya Higashiyama, Daisuke Sugiyama, Aya Hirata, Mizuki Sata, Takumi Hirata, Yoko Nishida, Sachimi Kubo, Yoshimi Kubota, Aya Kadota, Naomi Miyamatsu, Kunihiro Nishimura, Yoshihiro Miyamoto, Tomonori Okamura
    [Nihon koshu eisei zasshi] Japanese journal of public health 67 8 509 - 517 2020年 研究論文(学術雑誌) 
    Objective To explore health-related and socioeconomic factors that can predict future deterioration in Psychological Distress Scale (K6) scores.Method We conducted a baseline (2010, 2011) self-administered questionnaire survey of the Kobe Orthopedic and Biomedical Epidemiological study (KOBE study) involving 1,117 participants who had no previous history of cancer or cardiovascular diseases and were not under treatment for hypertension, diabetes, or dyslipidemia. We used the Japanese K6 as an indicator of stress and defined K6≧5 points as a high-stress group and K6<5 points as a low-stress group. A four-year follow-up survey (2014, 2015) was conducted on 1,004 people (follow-up rate of 90%). We excluded 39 participants with missing values, and 185 people whose K6 score was higher than 5 points at baseline. A final total of 780 participants' scores were examined for: gender, age, living situation, physical activity level, average sleep time, as well as the K6 score, the Japanese Hearing Handicap Inventory for Elderly (HHIE-S), and the Japanese Oswestry Disability Index (ODI). We conducted a logistic regression analysis using K6≧5 points at the four-year follow-up survey as the dependent variable and each factor at the baseline survey as the independent variable.Results Of the 780 subjects analyzed, 132 (16.9%) were highly stressed (K6≧5 points) at the four-year follow-up point. A logistic regression analysis found age (40s/70s) (odds ratio 3.38, 95% confidence interval 1.45-7.86), living situation (single/living together) (odds ratio 1.98, 95% confidence interval 1.07-3.68), and ODI scores (every 1%) (odds ratio 1.05, 95% confidence interval 1.01-1.09), to all be significantly associated with high stress.Conclusion This study suggests that age, living situation, and ODI scores are related to future stress.
  • Miki Nozawa, Kazuyo Kuwabara, Yoshimi Kubota, Yoko Nishida, Sachimi Kubo, Takumi Hirata, Aya Higashiyama, Aya Hirata, Hiroko Hattori, Mizuki Sata, Aya Kadota, Daisuke Sugiyama, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    [Nihon koshu eisei zasshi] Japanese journal of public health 67 10 722 - 733 2020年 研究論文(学術雑誌) 
    Objective Several studies have suggested that high dietary Na/K ratio and body mass index (BMI) increase the prevalence of hypertension. However, there have been a few reports on the combination of these two factors and their relationship with hypertension. This study aimed to examine the association of the combined estimated 24-h urinary Na/K ratio (24h-u-Na/K) (high or low) and BMI (high or low) with the risk of high blood pressure.Method We performed a cross-sectional study involving 1,112 participants (340 men and 772 women) of the Kobe Orthopedic and Biomedical Epidemiological study (KOBE study) who had no cardiovascular diseases or current anti-hypertensive medications. Sex-specific analyses were performed. The 24h-u-Na/K ratio was calculated from an estimation formula using collected spot urine. Participants were divided into four groups based on their 24h-u-Na/K ratio (low or high) and BMI (low or high), with the cutoff points being the median and 25 kg/m2, respectively. Participants with systolic blood pressure (SBP) ≥130 mmHg or diastolic blood pressure (DBP) ≥80 mmHg were diagnosed with high blood pressure. Odds ratios (ORs) for high blood pressure according to the combined risks of high 24h-u-Na/K and BMI were examined with a logistic regression analysis.Results The average SBP/DBP for men and women was 122.7/77.9 and 113.3/69.1 mmHg, respectively, and prevalence of high blood pressure among men and women was 47.4% and 21.3%, respectively. The mean BMI was 22.8 kg/m2 for men and 20.9 kg/m2 for women. The median 24h-u-Na/K was 3.2 for men and 3.1 for women. The prevalence of high blood pressure (men, women) was the highest in the group in which both 24h-u-Na/K and BMI were high (60.0%, 62.9%; men: P=0.273; women: P<0.001). In the same group, the multivariate-adjusted ORs for high blood pressure were significantly higher for both men (2.59; 95% confidence interval [CI]: 1.15-5.86) and women (10.78; 95% CI: 4.87-23.88) compared to the reference group with both factors classified as low. Women with low BMI but high 24h-u-Na/K also demonstrated a higher risk for high blood pressure (OR: 1.62; 95% CI: 1.10-2.40).Conclusion The risk of high blood pressure was the highest when both BMI and 24h-u-Na/K were high. The current specific healthcare guidance in Japan is focused on obese individuals. However, in order to prevent hypertension more effectively, additional focus should be placed on the Na/K diet. Increased intake of vegetables and fruits and reduced intake of salt should be strongly recommended.
  • Mohammad Moniruzzaman, Aya Kadota, Maksudul Shadat Akash, Patrick J Pruitt, Katsuyuki Miura, Roger Albin, Hiroko H Dodge
    Alzheimer's & dementia (New York, N. Y.) 6 1 e12109  2020年 研究論文(学術雑誌) 
    Introduction: Physical activities (PA) may lead to improved cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), and dementia. The mechanisms mediating potential PA effects are unknown. Assessment of PA effects on relevant biomarkers may provide insights into mechanisms underlying potential PA effects on cognition. Methods: We systematically reviewed randomized controlled trials (RCTs) that studied PA effects on biomarkers in MCI, AD, and dementia populations. We examined whether biological mechanisms were hypothesized to explain associations among PA, biomarkers, and cognitive functions. We used the PubMed database and searched for RCTs with PA until October 31, 2019. Results: Of 653 studies examining changes in biomarkers in PA trials, 18 studies met inclusion criteria for the present review. Some studies found favorable effects of PA on neurotrophic and inflammatory biomarkers. AD pathological markers were rarely investigated, with inconclusive results. Most studies were relatively small in sample size, of limited duration, and not all studies compared the changes in biomarkers between the control and experimental groups. Discussion: There is only limited use of potentially informative biomarkers in PA trials for MCI, AD, and dementia. Most studies did not examine the role of biomarkers to study associations between PA and cognitive functions in their analyses. Several potential biomarkers remain uninvestigated. Careful use of biomarkers may clarify mechanisms underlying PA effects on cognition. Our review serves as a useful resource for developing future PA RCTs aimed at improving cognitive functions in MCI, AD, and dementias.
  • Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort, Study Group
    Journal of lipid research 61 1 86 - 94 2020年01月 [有り][無し]
     研究論文(学術雑誌) 
    Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.
  • Yuyan Liu, Akira Fujiyoshi, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Itsuko Miyazawa, Keiko Kondo, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of atherosclerosis and thrombosis 26 12 1102 - 1114 2019年12月 [有り][無し]
     研究論文(学術雑誌) 
    AIM: Computed tomography (CT) can directly provide information on body compositions and distributions, compared to anthropometric indices. It has been shown that various obesity indices are associated with carotid intima-media thickness (IMT). However, whether CT-based obesity indices are stronger than anthropometric indices in association with atherosclerosis remains to be determined in a general population. METHODS: We cross-sectionally assessed carotid IMT using ultrasound in 944 community-dwelling Japanese men free of stroke and myocardial infarction. CT image at the L4-L5 level was obtained to compute areas of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Anthropometric measures assessed included body mass index (BMI), waist circumference, and waist-to-hip ratio. Using multivariable linear regression, slopes of IMT per 20th to 80th percentile of each index were compared. We also compared the slope of index with simultaneous adjustment for BMI in the same model. RESULTS: Areas of VAT and SAT were positively associated with IMT, but not stronger than those of anthropometric indices in point estimates. Among all obesity indices, BMI was strongest in association with IMT after adjusting for age and lifestyle factors or further adjusting for metabolic factors. In simultaneous adjustment models, BMI, but not CT-based indices, remained significant and showed the strongest association. CONCLUSIONS: In community-dwelling Japanese men, anthropometric obesity indices, BMI in particular, were more strongly associated with carotid atherosclerosis than CT-based obesity indices. The association of general obesity with carotid atherosclerosis was strong and adding CT-based obesity measure did not considerably influence in the association.
  • 都市住民における生活習慣と腎機能低下の進行との関連 神戸研究
    平田 あや, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 佐田 みずき, 西田 陽子, 久保 佐智美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 78回 352 - 352 日本公衆衛生学会 2019年10月
  • 一般地域住民における血清DHA濃度は腎機能低下と関連するのか 神戸研究
    久保 佐智美, 東山 綾, 杉山 大典, 平田 匠, 西田 陽子, 久保田 芳美, 桑原 和代, 宮松 直美, 門田 文, 西川 智文, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 78回 352 - 352 日本公衆衛生学会 2019年10月
  • 都市住民における出生体重と循環器疾患の危険因子との関連 神戸研究
    梅本 かおり, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 平田 あや, 佐田 みずき, 西田 陽子, 久保 佐智美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 78回 354 - 354 日本公衆衛生学会 2019年10月
  • 一般住民における皮膚乾燥とかゆみの要因の検討 神戸研究
    西田 陽子, 東山 綾, 杉山 大典, 平田 匠, 久保 佐智美, 久保田 芳美, 桑原 和代, 宮松 直美, 門田 文, 西川 智文, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 78回 360 - 360 日本公衆衛生学会 2019年10月
  • 宮澤 伊都子, 大久保 孝義, 村上 陽子, 永谷 幸裕, 佐藤 滋高, 藤吉 朗, 久松 隆史, 門田 文, 門脇 紗也佳, 瀬川 裕佳, 近藤 慶子, 新田 哲久, 前川 聡, 三浦 克之, 上島 弘嗣
    肥満研究 25 Suppl. 250 - 250 (一社)日本肥満学会 2019年10月 [有り][無し]
  • 若中年成人における孤立性収縮期高血圧および孤立性拡張期高血圧の予後予測能の検討,NIPPON DATA80
    久松 隆史, 三浦 克之, 大久保 孝義, 門田 文, 近藤 慶子, 喜多 義邦, 早川 岳人, 神田 秀幸, 岡村 智教, 岡山 明, 上島 弘嗣
    日本高血圧学会総会プログラム・抄録集 42回 302 - 302 (NPO)日本高血圧学会 2019年10月 [有り][無し]
  • 糖尿病患者における喫煙者の推移 滋賀県医師会実態調査2006年-2012年から
    森野 勝太郎, 宮澤 伊都子, 門田 文, 三浦 克之, 岡本 元純, 中村 隆志, 前川 聡, 大西 淳夫
    日本動脈硬化学会総会プログラム・抄録集 51回 1 - 4 (一社)日本動脈硬化学会 2019年07月 [有り][無し]
  • Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H, SESSA Research Group, for the NIPPON DATA, Research Group
    Journal of atherosclerosis and thrombosis 26 8 746 - 746 2019年07月 [有り][無し]
     研究論文(学術雑誌)
  • Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of epidemiology 29 6 205 - 212 2019年06月 [有り][無し]
     
    BACKGROUND: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. METHODS: From 2006-2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1-160.9, 161-321.9, 322-482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. RESULTS: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. CONCLUSIONS: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.
  • Liu L, Miura K, Kadota A, Fujiyoshi A, Gracely EJ, Xue F, Liu Z, Takashima N, Miyagawa N, Ohkubo T, Arima H, Okayama A, Okamura T, Ueshima H
    Journal of diabetes and its complications 33 6 417 - 423 2019年06月 [有り][無し]
  • Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Yoshino Saito, Itsuko Miyazawa, Akihiko Shiino, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Sayuki Torii, Naoyuki Takashima, Ikuo Tooyama, Hirotsugu Ueshima
    Journal of epidemiology 30 6 244 - 252 2019年05月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: The association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. METHODS: Our cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up. Higher CASI score (range 0 to 100) indicates better cognition. Proteinuria was assessed by dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m2) or by proteinuria (no, trace, and positive), considered normal, moderate, and advanced, respectively. Using linear regression, we computed mean CASI score with simultaneous adjustment for proteinuria and eGFR in addition to other potential confounders. RESULTS: Significant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (Ptrend=0.029), and 90.0, 88.5, and 88.5 for eGFR (Ptrend=0.015) in mutual adjustment model. CONCLUSIONS: Proteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline.
  • Liu Z, Zaid M, Hisamatsu T, Tanaka S, Fujiyoshi A, Miyagawa N, Ito T, Kadota A, Tooyama I, Miura K, Ueshima H
    Journal of epidemiology 30 3 121 - 127 2019年05月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men.
  • Kondo K, Miura K, Tanaka-Mizuno S, Kadota A, Arima H, Okuda N, Fujiyoshi A, Miyagawa N, Yoshita K, Okamura T, Okayama A, Ueshima H, NIPPON DATA, Research Group
    Circulation journal : official journal of the Japanese Circulation Society 83 6 1254 - 1260 2019年05月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Many studies show that dietary factors such as vegetables, fruit, and salt are associated with cardiovascular disease (CVD) risk. However, a risk assessment chart for CVD mortality according to combinations of dietary factors has not been established.Methods and Results:Participants were 9,115 men and women aged 30-79 years enrolled in the National Nutritional Survey of Japan in 1980 with a 29-year follow-up. Dietary intake was assessed using a 3-day weighed dietary record at baseline. Cox regression models were used to estimate the hazard ratio (HR) of CVD mortality stratified by vegetables, fruit, fish, and salt consumption. HRs of CVD mortality according to combinations of dietary factors were color coded on an assessment chart. Higher intakes of vegetables, fruit, and fish, and lower salt intake were associated with lower CVD mortality risk. HRs calculated from combinations of dietary factors were displayed using 5 colors corresponding to the magnitude of the HR. People with the lowest intake of vegetables, fruit, and fish, and higher salt intake had a HR of 2.87 compared with those with the highest intake of vegetables, fruit, and fish, and lower salt intake. CONCLUSIONS: Vegetables, fruit, fish, and salt intake were independently associated with CVD mortality risk. The assessment chart generated could be used in Japan as an educational tool for CVD prevention.
  • Mahajan H, Choo J, Masaki K, Fujiyoshi A, Guo J, Evans R, Shangguan S, Willcox B, Barinas-Mitchell E, Kadota A, Miura K, Kuller L, Shin C, Ueshima H, Sekikawa A
    Nutrition, metabolism, and cardiovascular diseases : NMCD 29 8 837 - 846 2019年05月 [有り][無し]
  • Suzuki H, Kadota A, Okuda N, Hayakawa T, Nishi N, Nakamura Y, Arima H, Miyagawa N, Satoh A, Miyamatsu N, Yanagita M, Yatsuya H, Yamagata Z, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K, NIPPON DATA, Research Group
    Environmental health and preventive medicine 24 1 37  2019年05月 [有り][無し]
     研究論文(学術雑誌)
  • Okuda N, Kadota A, Nishi N, Miura K, Ohkubo T, Miyagawa N, Satoh A, Kita Y, Hayakawa T, Takashima N, Fujiyoshi A, Okayama A, Okamura T, Ueshima H, NIPPON DATA, Research Group
    Circulation journal : official journal of the Japanese Circulation Society 83 7 1506 - 1513 2019年05月 [有り][無し]
  • Yuki Iwasaki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Mineko Tsukamoto, Yuka Kadomatsu, Rieko Okada, Asahi Hishida, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Keiichi Shimatani, Etsuko Ozaki, Teruhide Koyama, Sadao Suzuki, Hiroko Nakagawa-Senda, Kiyonori Kuriki, Naoko Miyagawa, Aya Kadota, Hiroaki Ikezaki, Norihiro Furusyo, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kenji Wakai
    Nutrients 11 5 2019年04月 研究論文(学術雑誌) 
    : The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B2 pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.
  • Kubo S, Nishida Y, Kubota Y, Higashiyama A, Sugiyama D, Hirata T, Miyamatsu N, Tanabe A, Hirata A, Tatsumi Y, Kadota A, Kuwabara K, Nishikawa T, Miyamoto Y, Okamura T
    BMC nephrology 20 1 117 - 117 2019年04月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD). METHODS: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. The preconditions for participation in this study were no past histories of cardiovascular disease or cancer, and not undergoing treatment for diabetes, hypertension, or dyslipidemia. We classified the participants into quartiles stratified by sex according to their SUA level and then examined the relationship with eGFR. The odds ratios for having a low eGFR, defined as the lowest quartile of eGFR (i.e., ≤78.4 mL/min/1. 73m2) was estimated according to SUA quartiles (men, Q1 ≤ 5.0, Q2 5.1-5.9, Q3 6.0-6.6, and Q4 ≥ 6.7; women, Q1 ≤ 3.8, Q2 3.9-4.3, Q3 4.4-4.9, and Q4 ≥ 5.0 mg/dL) after adjustment for age, body mass index, systolic blood pressure, HbA1c, high and low density lipoprotein cholesterol, and smoking and drinking habits. The adjusted mean of each quartile was also calculated. RESULTS: Multivariable-adjusted means of eGFR showed a graded decrease in higher SUA quartiles (men, Q1 90.5, Q2 88.0, Q3 83.5, and Q4 82.0; women, Q1 95.7, Q2 91.3, Q3 89.2, and Q4 86.7). In addition, the multivariable-adjusted odds ratios for having a lower eGFR (95% confidence interval) for each SUA quartile compared with Q1 was Q2 2.29 (0.98, 5.35), Q3 4.94 (2.04, 11.97), and Q4 8.01 (3.20, 20.04) for men, and was Q2 2.20 (1.12, 4.32), Q3 2.68 (1.39, 5.20), and Q4 4.96 (2.62, 9.41) for women. CONCLUSIONS: There was a graded inverse relationship between mild elevations in SUA levels and eGFR assessed by cystatin C in an apparently healthy Japanese population without CKD. This association was similar in both men and women.
  • 12年間継続して観察しえた糖尿病診療の推移 滋賀県医師会糖尿病実態調査より
    宮澤 伊都子, 門田 文, 三浦 克之, 岡本 元純, 中村 隆志, 越智 眞一, 前川 聡, 大西 淳夫
    糖尿病 62 Suppl.1 S - 324 (一社)日本糖尿病学会 2019年04月
  • Miyazawa I, Miura K, Miyagawa N, Kondo K, Kadota A, Okuda N, Fujiyoshi A, Chihara I, Nakamura Y, Hozawa A, Nakamura Y, Kita Y, Yoshita K, Okamura T, Okayama A, Ueshima H, NIPPON DATA, Research group
    European journal of clinical nutrition 74 1 67 - 76 2019年04月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND/OBJECTIVES: The association between carbohydrate intake and cardiovascular disease (CVD) risk has been investigated, but whether the quality of carbohydrate is more important than its amount is not known. We examined the associations between intake of dietary fibre (DF), carbohydrate, available carbohydrate, and starch with long-term CVD mortality in a Japanese population. SUBJECTS/METHODS: We prospectively followed 8925 participants (3916 men and 5009 women) aged 30-79 years without CVD at baseline who participated in the National Nutrition Survey in Japan. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) for CVD mortality by quartiles of exposure variables. RESULTS: During 24 years of follow-up, 823 CVD deaths were observed. In men, the multivariable-adjusted HR for CVD mortality was lower in the highest quartile of DF intake (HR: 0.64; 95% CI: 0.47-0.87; Ptrend = 0.007) compared with the lowest quartile. This association was not significant in women. Multivariable-adjusted HR for total stroke mortality was lower in the highest quartile of DF intake (HR: 0.61; 95% CI: 0.38-0.98; Ptrend = 0.046) compared with the lowest quartile in women. Carbohydrate, available carbohydrate, and starch intake were not associated with CVD mortality. CONCLUSIONS: Higher intake of DF was associated significantly with a lower risk of CVD mortality in men and lower risk of stroke mortality in women. Intake of carbohydrate, available carbohydrate, and starch were not associated with the risk of CVD mortality in men or women.
  • Satoh A, Arima H, Hozawa A, Ohkubo T, Hisamatsu T, Kadowaki S, Kadota A, Fujiyoshi A, Miyagawa N, Zaid M, Torii S, Okamura T, Sekikawa A, Miura K, Ueshima H, SESSA Research Group
    Journal of hypertension 37 8 1676 - 1681 2019年04月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVE: We conducted a cross-sectional study to clarify whether home blood pressure (HBP) is more strongly associated with coronary artery calcification (CAC) than accurately measured office blood pressure (OBP) among the general population of Japanese men. METHODS: We analyzed the data of 919 Japanese male participants who were randomly selected from general population (mean age 64.5 years). OBP was measured twice consecutively by a trained nurse using electrical device after 5 min of complete rest alone in a sitting position in a silent room. The participants were asked to measure HBP with an electrical device once in the morning during 7 consecutive days. CAC was assessed using computed tomography. Presence of CAC was defined as Agatston score at least 10. We calculated odds ratios for the presence of CAC per one SD higher OBP and HBP adjusted for age and other cardiovascular risk factors. RESULTS: The mean systolic OBP (SD) and HBP (SD) were 136.8 (19.0) and 137.2 (18.5) mmHg, respectively, without statistical difference between the two (P = 0.595). OBP and HBP were highly correlated (r = 0.74 P < 0.001). CAC was found in 454 (49.4%) participants. Multivariable-adjusted odds ratios [95% confidence interval (CI)] for the presence of CAC were comparable between OBP (1.32, 95% CI: 1.12-1.56) and HBP (1.35, 95% CI: 1.14-1.60) (P heterogeneity = 0.813). CONCLUSION: The strength of association of accurately measured OBP with CAC was comparable with that of HBP among randomly selected male general population aged 40-79 years.
  • Ken Suzuki, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kanai, Jun Hosoe, Nobuhiro Shojima, Atsushi Hozawa, Aya Kadota, Kiyonori Kuriki, Mariko Naito, Kozo Tanno, Yasushi Ishigaki, Makoto Hirata, Koichi Matsuda, Nakao Iwata, Masashi Ikeda, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Shiro Ikegawa, Shiro Maeda, Yoshinori Murakami, Kenji Wakai, Shoichiro Tsugane, Makoto Sasaki, Masayuki Yamamoto, Yukinori Okada, Michiaki Kubo, Yoichiro Kamatani, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki
    Nature genetics 51 3 379 - 386 2019年03月 研究論文(学術雑誌) 
    To understand the genetics of type 2 diabetes in people of Japanese ancestry, we conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases and 155,150 controls of Japanese ancestry). We identified 88 type 2 diabetes-associated loci (P < 5.0 × 10-8) with 115 independent signals (P < 5.0 × 10-6), of which 28 loci with 30 signals were novel. Twenty-eight missense variants were in linkage disequilibrium (r2 > 0.6) with the lead variants. Among the 28 missense variants, three previously unreported variants had distinct minor allele frequency (MAF) spectra between people of Japanese and European ancestry (MAFJPN > 0.05 versus MAFEUR < 0.01), including missense variants in genes related to pancreatic acinar cells (GP2) and insulin secretion (GLP1R). Transethnic comparisons of the molecular pathways identified from the GWAS results highlight both ethnically shared and heterogeneous effects of a series of pathways on type 2 diabetes (for example, monogenic diabetes and beta cells).
  • 一般日本人女性における受動喫煙状態と血管内皮機能との関連(Association of Passive Smoking Status to Endothelial Vascular Function among General Japanese Women)
    門田 文, 近藤 慶子, 久松 隆史, 宮澤 伊都子, 藤吉 朗, 上島 弘嗣, 三浦 克之
    日本循環器学会学術集会抄録集 83回 PJ041 - 4 2019年03月 [有り][無し]
  • Trang Thi Minh Nguyen, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Taichiro Tanaka, Yasuyuki Nakamura, Akira Fujiyoshi, Aya Kadota, Junko Tamaki, Toru Takebayashi, Tomonori Okamura, Hirotsugu Ueshima
    Hypertension research : official journal of the Japanese Society of Hypertension 42 3 411 - 418 2019年03月 [有り][無し]
     研究論文(学術雑誌) 
    While the association between 24-h urinary sodium and potassium excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and potassium excretion were based on Tanaka's formula. Overall, a single standard deviation increase in the estimated sodium excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P < 0.001). A single standard deviation increase in estimated potassium excretion (8.9 mmol/day) was associated with a 1.1 mmHg lower systolic blood pressure and a 0.7 mmHg lower diastolic blood pressure (P < 0.001). As a combined measure of the excretion of both electrolytes, the estimated 24-h sodium-to-potassium ratio was positively associated with both blood pressures (P < 0.001). Associations of blood pressure with sodium and the sodium-to-potassium ratio increased with age and were stronger in men compared to women. Associations with potassium and the sodium-to-potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals.
  • Tsukinoki R, Okamura T, Okuda N, Kadota A, Murakami Y, Yanagita M, Miyamatsu N, Miura K, Ueshima H
    Journal of occupational health 61 2 189 - 196 2019年03月 [有り][無し]
  • Yang Y, Hozawa A, Kogure M, Narita A, Hirata T, Nakamura T, Tsuchiya N, Nakaya N, Ninomiya T, Okuda N, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 30 2 98 - 107 2019年02月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: It has been reported that chronic inflammation may play an important role in the pathogenesis of several serious diseases and could be modulated by diet. Recently, the Dietary Inflammatory Index (DII®) was developed to assess the inflammatory potential of the overall diet. The DII has been reported as relevant to various diseases but has not been validated in Japanese. Thus, in the present study, we analyzed the relationship between DII scores and high-sensitivity C-reactive protein (hs-CRP) levels in a Japanese population. METHODS: Data of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010), which contained 2,898 participants aged 20 years or older from the National Health and Nutrition Survey of Japan (NHNS2010), were analyzed. Nutrient intakes derived from 1-day semi-weighing dietary records were used to calculate DII scores. Energy was adjusted using the residual method. Levels of hs-CRP were evaluated using nephelometric immunoassay. Multiple linear regression analyses were performed. RESULTS: After adjusting for age, sex, smoking status, BMI, and physical activity, a significant association was observed between DII scores and log(CRP+1) (standard regression coefficient = 0.05, P < 0.01). Although it was not statistically significant, the positive association was consistently observed in almost all age-sex subgroups and the non-smoker subgroup. CONCLUSIONS: The current study confirmed that DII score was positively associated with hs-CRP in Japanese.
  • NMR-Measured Lipoprotein Particle Distributions and Coronary Artery Calcification in US White and Japanese Men Aged 40-49 Years
    Mahajan H, Zaid M, Mackey R, Kadota A, Vishnu A, Fujiyoshi A, Ahuja V, Hisamatsu T, Evans R, Okamura T, Miura K, Kuller L, Ueshima H, Sekikawa A
    Open Heart 2019年 [有り][無し]
  • Nishikawa T, Miyamatsu N, Higashiyama A, Hojo M, Nishida Y, Fukuda S, Hirata T, Ichiura K, Kubota Y, Kubo S, Ueba T, Kadota A, Sugiyama D, Okamura T
    Cerebrovascular diseases (Basel, Switzerland) 47 3-4 143 - 150 2019年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: While water intake is frequently recommended to prevent cerebral infarction (CI), only few studies have been published on this topic. OBJECTIVES: This study retrospectively estimated the daily non-alcohol drink (NAD) intake in CI patients before CI onset and compared it with NAD in healthy subjects. METHODS: We performed a cross-sectional study on CI patients in 3 hospitals and healthy subjects in the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) study. Data from 1,287 subjects (274 CI patients and 1,013 healthy subjects) were used for the analyses. By dividing the CI patients into "increased", "unchanged", and "decreased" groups according to their current NAD intake, we compared the NAD intake between these 3 groups and healthy subjects by analyses of covariance and the post hoc test, adjusting for sex, age, surveyed month, body mass index, alcohol drinking history, and smoking history. Under the assumption that the NAD intake in the "unchanged" group was equal to the NAD intake before CI onset, the OR of less NAD intake for CI adjusting for the relevant variables in the "unchanged" group and the healthy subjects was calculated; the cut-off point was chosen using Youden's index. RESULTS: The mean age (mean ± SD) of the participants was 62.8 ± 9.3 years. One hundred and fifty-one patients (36 women) were included in the "increased" group; 105 (30 women), in the "unchanged" group; 18 (2 women), in the "decreased" group; and 1,013 (706 women), in the "healthy" group. The mean NAD intake was 1,702.5 ± 670.2 mL in the "increased" group, 1,494.2 ± 611.2 mL in the "unchanged" group, 1,268.0 ± 596.1 mL in the "decreased" group, and 1,720.6 ± 686.0 mL in the "healthy" group. After adjusting for the relevant variables, a significant difference in NAD intake between the groups was observed (F = 6.1, p < 0.001), and a post hoc test demonstrated significant differences (p < 0.05) in NAD intake between the "healthy" and "unchanged" groups, and between the "increased" and "unchanged" groups. The OR of less NAD intake (<1,570 mL/day, chosen using Youden's index) for CI was 2.48 (95% CI 1.52-4.07). CONCLUSION: This study showed that daily NAD intake before CI onset in CI patients was less than that in healthy persons, indicating that sufficient intake of NAD may be protective for CI.
  • Hemant Mahajan, Maryam Zaid, Rachel Mackey, Aya Kadota, Abhishek Vishnu, Akira Fujiyoshi, Ahuja Vasudha, Takashi Hisamatsu, Rhobert Evans, Tomonori Okamura, Katsuyuki Miura, Lewis Kuller, Hirotsugu Ueshima, Akira Sekikawa
    Open heart 6 2 e001119  2019年 [有り][無し]
     
    Objective: This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese). Methods: In a population-based study of 570 randomly selected asymptomatic men aged 40-49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD). Results: The US-White compared with the Japanese had significantly different NMR-measured lipoprotein particle distributions. The US-White had a significantly higher prevalence of CAC≥10 (CAC-prevalence) compared with the Japanese adjusting for CHD risk factors (prevalence ratio (PR)=2.10; 95% CI=1.24 to 3.48), and this difference was partially attenuated (~18%) with further adjustment for lipoprotein levels (PR=1.73; 95% CI=1.02 to 3.08). There was no reclassification improvement with further addition of lipoproteins particle concentrations/size to a model that already included traditionally measured lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), cardiovascular risk factors, and inflammatory markers (net reclassification improvement index=-2% to 3%). Conclusions: Variations in the distribution of NMR-measured lipoprotein particles partially accounted for the difference in the CAC-prevalence between middle-aged US-White and Japanese men.
  • Nakamura M, Ojima T, Nagahata T, Kondo I, Ninomiya T, Yoshita K, Arai Y, Ohkubo T, Murakami K, Nishi N, Murakami Y, Takashima N, Okuda N, Kadota A, Miyagawa N, Kondo K, Okamura T, Ueshima H, Okayama A, Miura K, NIPPON DATA, Research Group
    Environmental health and preventive medicine 24 1 1 - 1 2019年01月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Oral health is thought to be associated with diet quality, and socioeconomic status (SES) affects both oral health and diet. The aim of this study was to investigate the association between the number of teeth and dietary intake as well as nutritional biomarker, considering the subjects' SES. METHODS: We conducted a cross-sectional analysis of data from 2049 individuals aged ≥ 50 years from the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010. The number of remaining teeth was categorized into age-specific quartiles (Q1 to Q4). We assessed the adjusted means and 95% confidence intervals for dietary variables by the number of teeth using analysis of covariance. Stratified analyses by SES were also conducted. RESULTS: The intake of grain products was 31 g higher, and those of vegetables and meat were 30 g and 8 g lower, respectively, in Q1 (fewer teeth) than in Q4 (more teeth). Carbohydrate intake was higher whereas protein, minerals (potassium, magnesium, and zinc), vitamins (vitamins A, E, B1, B6, β-carotene, and folic acid), and dietary fiber intakes were lower among individuals with fewer teeth. Adjusted mean serum albumin levels were low in Q1. The associations between the number of teeth and dietary intake were more evident in individuals with a low SES. CONCLUSIONS: Having few remaining teeth was associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese adults, and these associations were more evident in individuals with low SES.
  • Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Keiko Kondo, Aya Kadota, Nagako Okuda, Tomonori Okamura, Katsuyuki Miura
    Circulation journal : official journal of the Japanese Circulation Society 83 1 147 - 155 2018年12月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: In recent years, individuals with high serum total cholesterol (TC) have been more likely to modify their diet by reducing their intake of dietary lipids. The aim of this study was to investigate time-related changes in the relationships between the Keys score, dietary lipids, and TC between 1980 and 2010 in representative Japanese populations. Methods and Results: We used 3 cross-sectional cohort studies conducted among Japanese representative populations in 1980, 1990, and 2010 (NIPPON DATA80/90/2010) for the analyses. We analyzed data for 10,365, 7,714, and 2,657 participants, respectively, in each dataset. The relationships between TC and the Keys score (calculated by dietary lipids, cholesterol, and energy intake)/dietary lipids were examined. In men, a 1-unit higher Keys score correlated with 0.92 mg/dL and 0.64 mg/dL TC in 1980 and 1990, respectively, but not in 2010. In women, a 1-unit higher Keys score correlated with 0.70 mg/dL and 0.74 mg/dL TC in 1980 and 1990, respectively, but with 0.33 mg/dL in 2010. In men and women, dietary cholesterol, saturated fatty acid (SFA), and trans fatty acid (TFA) levels were positively associated with TC concentrations in 1980 and 1990, but not in 2010. CONCLUSIONS: In these representative Japanese populations, a higher Keys score as well as dietary cholesterol, SFA, and TFA levels correlated with higher TC concentrations in 1980/1990, but the relationships were weaker or not observed in 2010.
  • Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Hosono A, Katsuura-Kamano S, Arisawa K, Kuriki K, Endoh K, Takashima N, Kadota A, Nakatochi M, Momozawa Y, Kubo M, Naito M, Wakai K
    Medicine and science in sports and exercise 50 12 2433 - 2441 2018年12月 [有り][無し]
     研究論文(学術雑誌) 
    PURPOSE: Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results. METHODS: We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study. RESULTS: We found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples. CONCLUSIONS: We identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior.
  • Hisamatsu T, Miura K, Ohkubo T, Arima H, Fujiyoshi A, Satoh A, Kadota A, Zaid M, Takashima N, Ohno S, Horie M, Ueshima H, SESSA Research Group
    Journal of hypertension 36 11 2193 - 2203 2018年11月 [有り][無し]
     研究論文(学術雑誌)
  • Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, ACCESS, SESSA Research Groups
    Atherosclerosis 278 336 - 336 2018年11月 [有り][無し]
  • Kimani C, Kadota A, Miura K, Fujiyoshi A, Zaid M, Kadowaki S, Hisamatsu T, Arima H, Horie M, Ueshima H, SESSA Research Group
    Journal of atherosclerosis and thrombosis 26 5 452 - 464 2018年11月 [有り][無し]
     研究論文(学術雑誌)
  • 近藤慶子, 門田文, 門田文, 大久保孝義, 平田匠, 筒井秀代, 岡村智教, 三浦克之, 三浦克之
    日本腎臓学会誌 60 7 1011‐1022  2018年10月 [無し][無し]
  • 食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010
    大塚 礼, 八谷 寛, 西 信雄, 奥田 奈賀子, 門田 文, 由田 克士, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 77回 322 - 322 日本公衆衛生学会 2018年10月
  • Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group
    International Journal of Cardiology 267 177 - 182 2018年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. Methods and results: We performed a prospective, population-based study of Japanese men aged 40–79 years without known coronary heart disease. We measured baseline serum irisin levels using an enzyme-linked immunosorbent assay and quantified coronary artery calcification (CAC) from serial computed tomography scans. Of 1038 participants (mean age, 63.9 years) at baseline, 670 (64.6%) had prevalent CAC. Of 810 participants at follow-up (median, 5.1 years), 407 (50.3%) experienced CAC progression. In Poisson regression with robust error variance adjusted for age and behavioral factors, serum irisin levels were inversely associated with CAC prevalence (relative risk [RR] of 4th versus 1st quartiles [95% confidence interval], 0.88 [0.78–0.99] trend P = 0.016) and CAC progression (RR, 0.76 [0.63–0.91] trend P = 0.002). After further adjustment for cardiometabolic risk factors, the inverse association with CAC prevalence disappeared (RR, 0.95 [0.84–1.08] trend P = 0.319), but that with CAC progression persisted (RR, 0.77 [0.64–0.93] trend P = 0.003). These associations were consistent when we applied ordinal logistic regression and across subgroups by cardiometabolic risk factor status. Conclusions: Higher serum irisin levels were associated with less burden of coronary atherosclerosis. This association would be mediated through and beyond traditional cardiometabolic pathways.
  • Abhishek Vishnu, Jina Choo, Aya Kadota, Emma J.M. Barinas-Mitchell, Akira Fujiyoshi, Dorothy Leann Long, Takashi Hisamatsu, Vasudha Ahuja, Yasuyuki Nakamura, Rhobert W. Evans, Katsuyuki Miura, Kamal H. Masaki, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa
    International Journal of Cardiology 266 245 - 249 2018年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Carotid plaque has emerged as a marker of coronary heart disease (CHD) risk. Comparison of carotid plaque burden between different race/ethnic groups may provide a relative estimate of their future CHD risk. Methods: We conducted a population-based study among apparently healthy middle-aged men aged 40–49 years (ERA JUMP study (n = 924)) and recruited 310 Whites in Pittsburgh, US, 313 Japanese in Otsu, Japan, and 301 Koreans in Ansan, South Korea. The number of carotid plaque and CHD risk factors was assessed using a standardized protocol across all centers. The burden of carotid plaque was compared between race/ethnic groups after adjustment for age and BMI, and after multivariable adjustment for other CHD risk factors using marginalized zero-inflated Poisson regression models. Cross-sectional associations of risk factors with plaque were examined. Results: Whites (22.8%) had more than four-fold higher prevalence (p < 0.01) of carotid plaque than Japanese men (4.8%) while the prevalence among Koreans was 10.6%. These differences remained significant after adjustment for age, BMI as well as other risk factors – incidence density ratio (95% confidence interval) for plaque was 0.13 (0.07, 0.24) for Japanese and 0.32 (0.18, 0.58) for Koreans as compared to Whites. Age, hypertension and diabetes were the only risk factors significantly associated with presence of carotid plaque in the overall population. Conclusion: Whites have significantly higher carotid plaque burden than men in Japan and Korea. Lower carotid plaque burden among Japanese and Koreans is independent of traditional CVD risk factors.
  • Miyazawa I, Ohkubo T, Kadowaki S, Fujiyoshi A, Hisamatsu T, Kadota A, Arima H, Budoff M, Murata K, Miura K, Maegawa H, Ueshima H, SESSA Research Group
    Circulation journal : official journal of the Japanese Circulation Society 82 10 2542 - 2548 2018年09月 [有り][無し]
     研究論文(学術雑誌)
  • Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Yoko Nishida, Sachimi Kubo, Takumi Hirata, Aya Kadota, Naomi Miyamatsu, Ichiro Wakabayashi, Yoshihiro Miyamoto, Tomonori Okamura
    Hypertension research : official journal of the Japanese Society of Hypertension 41 9 756 - 762 2018年09月 [有り][無し]
     研究論文(学術雑誌) 
    Excessive salt intake is an established risk factor for hypertension. We conducted a cross-sectional study to examine the association between salty taste recognition and estimated salt intake and masked hypertension in a healthy Japanese normotensive population. The participants were 892 apparently healthy community residents (246 men and 646 women) aged between 40 and 74 years with blood pressure below 140/90 mm Hg. Salty taste recognition was assessed using a salt-impregnated taste strip. Daily salt intake was calculated as estimated 24 h urinary sodium excretion using spot urine tests. Each participant performed home blood pressure measurements for a minimum of 5 days per week. The participants were classified into three groups according to their salty taste recognition threshold evaluated by the salt concentrations of the taste strips (0.6%, 0.8%, and ≥ 1.0%). In women, the multivariate odds ratio (95% confidence interval) for masked hypertension ( ≥ 135/85 mm Hg) was 2.98 (1.16-7.64) in the ≥ 1.0% group compared with that in the 0.6% group. In men, the proportion of masked hypertension in the ≥ 1.0% group did not differ from that in the 0.6% group, and no correlation was identified between estimated daily salt intake and the salty taste recognition threshold. In conclusion, impairment of salty taste recognition was associated with masked hypertension in women even with normal blood pressure in the clinical setting.
  • Kurihara A, Okamura T, Sugiyama D, Higashiyama A, Watanabe M, Okuda N, Kadota A, Miyagawa N, Fujiyoshi A, Yoshita K, Ohkubo T, Okayama A, Miura K, Ueshima H, NIPPON DATA, Research Group
    Journal of atherosclerosis and thrombosis 2018年08月 [有り][無し]
  • Y. Murakami, R. Tsukinoki, K. Miura, T. Okamura, A. Kadota, A. Okayama, H. Ueshima
    Revue d'Épidémiologie et de Santé Publique 66 S329 - S330 2018年07月 研究論文(学術雑誌)
  • R. Tsukinoki, Y. Murakami, K. Miura, T. Okamura, A. Kadota, T. Hayakawa, A. Okayama, H. Ueshima
    Revue d'Épidémiologie et de Santé Publique 66 S326 - S326 2018年07月 研究論文(学術雑誌)
  • Fujiyoshi N, Arima H, Satoh A, Ojima T, Nishi N, Okuda N, Kadota A, Ohkubo T, Hozawa A, Nakaya N, Fujiyoshi A, Okamura T, Ueshima H, Okayama A, Miura K, NIPPON DATA, Research Group
    Journal of atherosclerosis and thrombosis 25 7 606 - 620 2018年07月 [有り][無し]
     研究論文(学術雑誌) 
    AIM: To investigate associations between socioeconomic status (SES) and the prevalence and treatment status of hypercholesterolemia in a general Japanese population. METHODS: In 2010, we established a cohort study of 2417 adults (age 20-91 yr) from 300 randomly selected areas across Japan who participated in the National Health and Nutrition Survey of Japan. We cross-sectionally examined an association between SES and (1) prevalence of hypercholesterolemia in 2417 participants (999 men and 1418 women) and (2) not receiving medication for hypercholesterolemia in 654 participants (215 men and 439 women). SES included employment status, marital status, length of education, and household expenditures. Hypercholesterolemia was defined as a total serum cholesterol level of ≥6.21 mmol/L (240 mg/dL) or the use of lipid-lowering medications. RESULTS: The overall prevalence of hypercholesterolemia was 21.5% in men and 31.0% in women. In men, the lowest quintile of household expenditures was associated with a higher prevalence of hypercholesterolemia (28.3%) compared with the upper 4 quintiles (19.9%) (multivariable-adjusted odds ratio 1.66; 95% confidence interval [CI] 1.16-2.38). Among participants with hypercholesterolemia, 55.4% of men and 55.1% of women were not receiving medication. Unmarried men were more likely to be untreated (75.0%) than married men (50.9%) (multivariable-adjusted odds ratio 2.53;95%CI 1.05-6.08). SES had no significant effects in women. CONCLUSION: In a general population of Japanese men, low household expenditures were associated with a higher prevalence of hypercholesterolemia, and unmarried men with hypercholesterolemia were less likely to receive medication.
  • Shibata Y, Ojima T, Nakamura M, Kuwabara K, Miyagawa N, Saito Y, Nakamura Y, Kiyohara Y, Nakagawa H, Fujiyoshi A, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 29 4 133 - 138 2018年07月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: The trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data. METHODS: Data of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia. RESULTS: A total of 5,734, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83-3.24 and 0.92; 95% CI, 0.66-1.27 among men and 1.43; 95% CI, 1.18-1.72 and 1.08; 95% CI, 0.81-1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95% CI, 0.12-0.60 and 0.37; 95% CI, 0.10-1.28 among men and 0.39; 95% CI, 0.26-0.57 and 0.96; 95% CI, 0.58-1.57 among women, respectively). CONCLUSIONS: These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.
  • Sekikawa A, Mahajan H, Kadowaki S, Hisamatsu T, Miyagawa N, Fujiyoshi A, Kadota A, Maegawa H, Murata K, Miura K, Edmundowicz D, Ueshima H, SESSA Research Group
    European journal of clinical nutrition 73 5 783 - 792 2018年07月 [有り][無し]
     研究論文(学術雑誌)
  • Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of atherosclerosis and thrombosis 25 6 477 - 489 2018年06月 [有り][無し]
     研究論文(学術雑誌) 
    AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization. We examined an independent relationship between each risk factor used in prediction models and CAC score ≥100 by logistic regression. We then divided the participants into quintiles of estimated CHD risk per prediction model to calculate odds ratio of having CAC score ≥100. Receiver operating characteristic curve and c-index were used to examine discriminative ability of prevalent CAC for each prediction model. RESULTS: Age, smoking status, and systolic blood pressure were significantly associated with CAC score ≥100 in the multivariable analysis. The odds of having CAC score ≥100 were higher for those in higher quintiles in all prediction models (p-values for trend across quintiles <0.0001 for all models). All prediction models showed fair and similar discriminative abilities to detect CAC score ≥100, with similar c-statistics (around 0.70). CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population.
  • Yasuyuki Nakamura, Tomonori Okamura, Yoshikuni Kita, Nagako Okuda, Aya Kadota, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    European Journal of Clinical Nutrition 72 6 841 - 847 2018年06月 [有り][無し]
     研究論文(学術雑誌) 
    Background/objective: Egg intake was associated with serum total cholesterol adjusted for age (aTCH) and total mortality in women, but not in men, using data from NIPPON DATA (ND) 80 which followed up for 14 years. Re-evaluation of these associations in a different cohort is needed. Subject/methods: We analyzed the associations of egg intake with aTCH and cause-specific and total mortality using the ND90 data set with a 15-year follow-up. A nutritional examination was done at the baseline in 1990 using the food-frequency method and by weighed food records. We followed 4686 female participants (ages ≥30 years), with no history of stroke or myocardial infarction (mean age 52.8 years) for 15 years. Results: The participants were divided into 5 egg intake groups (< 1/w, 1-2/w, 1/2d, 1/d, and ≥2/d). There were 203, 1462, 1594, 1387, and 40 women in each group, respectively. Egg intake was not associated with aTCH (P = 0.886). There were 183 cardiovascular disease (CVD), 210 cancer, and 599 total mortality cases during follow-up. Cox analysis, adjusted for background factors, found egg intake was directly associated with total and cancer mortality (HR in the ≥2/d vs.The 1 egg/d group: Total, 2.05 (95% CI: 1.20-3.52) cancer, 3.20 (1.51-6.76)), and that cancer mortality in the 1-2/w group was significantly less than that in the 1 egg/d group (0.68 (0.47-0.97)). Egg intake was not associated with CVD mortality. Conclusions: Egg intake was associated with cancer and total mortality. Reducing egg intake may have some definitive health benefits in women in Japan, at least.
  • Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group
    Atherosclerosis 273 145 - 152 2018年06月 [有り][無し]
     研究論文(学術雑誌) 
    Background and aims: Calcific aortic valve disease (CAVD) is the most common valve disease. Although micronutrients are known to contribute to cardiovascular disease, the relationship with CAVD remains poorly evaluated. We examined the association of serum levels of magnesium, phosphorus, and calcium with prevalence, incidence, and progression of aortic valve calcification (AVC). Methods: We conducted a prospective study in a population-based sample of Japanese men aged 40–79 years without known cardiovascular disease and chronic kidney disease at baseline, and quantified AVC from serial computed tomographic images with the Agatston method. Results: Of 938 participants at baseline (mean age, 63.7 ± 9.9 years), AVC prevalence was observed in 173 (18.4%). Of 596 participants without baseline AVC at follow-up (median duration, 5.1 years), AVC incidence was observed in 138 (23.2%). After adjustment for demographics, behaviors and cardiovascular risk factors, relative risks (95% confidence intervals) in the highest versus lowest categories of serum magnesium, phosphorus, and calcium were 0.62 (0.44–0.86), 1.45 (1.02–2.04), and 1.43 (0.95–2.15), respectively, for AVC prevalence and 0.62 (0.42–0.92), 1.93 (1.28–2.91), and 1.09 (0.77–1.55), respectively, for AVC incidence. Their linear trends of serum magnesium and phosphorus were also all statistically significant. Of 131 participants with baseline AVC, there was no association of any serum micronutrients with AVC progression. Conclusions: Serum magnesium was inversely associated, while serum phosphorus was positively associated with AVC prevalence and incidence, suggesting that these serum micronutrients may be potential candidates for risk prediction or prevention of CAVD, and warranting further studies.
  • Shohei Okamoto, Tomonori Okamura, Daisuke Sugiyama, Takehito Hayakawa, Yasuyuki Nakamura, Naoko Miyagawa, Shuji Kurita, Naoyuki Takashima, Takayoshi Ohkubo, Aya Kadota, Akira Fujiyoshi, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    Geriatrics and Gerontology International 18 5 799 - 805 2018年05月 [有り][無し]
     研究論文(学術雑誌) 
    Aim: The present study aimed to clarify the association between body mass index (BMI) and the activities of daily living (ADL). Although BMI is likely to be concerned regarding the relationship with specific diseases or mortality, few studies have focused on the relationship of BMI and ADL. Methods: A total of 3353 Japanese participants of a 22-year cohort study from 1990 to 2012 aged 45–74 years at baseline were divided into four groups according to their BMI levels: ≤18.5, 18.5–21.9 (reference), 22.0–24.9 and ≥25.0 kg/m2. Outcomes were becoming dependent in ADL (including death after ADL decline) and death without observation of ADL decline as a competing risk. Sex-specific multinomial logistic regression analysis was carried out in 2017 to estimate the odds ratios (OR) after adjusting for age, smoking, alcohol drinking, hypertension, hypercholesterolemia, diabetes and serum albumin. Results: After multivariable adjustment, though the relationship between BMI and risk of ADL decline was U-shaped among women, only those with BMI ≥25.0 showed a higher risk for ADL decline (OR 1.39, 95% CI 1.01–1.92) compared with the reference. The OR for death without observation of ADL decline was significantly lower for men with BMI ≥25.0 (OR 0.70, 95% CI 0.50–0.98). Conclusions: This study suggests being overweight is a good predictor of future decline in ADL for women, whereas men with BMI 22.0–24.9 had lower risks of ADL decline. Appropriate management of weight in older women could prevent disabilities. Geriatr Gerontol Int 2018 18: 799–805.
  • Sayaka Kadowaki, Katsuyuki Miura, Takashi Kadowaki, Akira Fujiyoshi, Aiman El-Saed, Kamal H. Masaki, Tomonori Okamura, Daniel Edmundowicz, Beatriz L. Rodriguez, Yasuyuki Nakamura, Emma J.M. Barinas-Mitchell, Aya Kadota, Bradley J. Willcox, Robert D. Abbott, Lewis H. Kuller, Jina Choo, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa
    Metabolic Syndrome and Related Disorders 16 4 166 - 173 2018年05月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Abdominal fat distribution varies across groups with different races or environments. Whether environmental factors, apart from racial differences, affect abdominal fat distribution is unknown. Methods: We compared the abdominal fat distribution of four groups different races with similar environments (Caucasians vs. Japanese Americans), different environments with an identical race (Japanese Americans vs. Japanese), and similar races with similar environments (Japanese vs. Koreans). A population-based sample of 1212 men aged 40-49 were analyzed: 307 Caucasians and 300 Japanese Americans in the United States, 310 Japanese in Japan, and 295 Koreans in Korea. We compared the proportion of visceral adipose tissue area to total abdominal adipose tissue area (VAT%) and other factors that can affect abdominal fat distribution (smoking, alcohol use, physical activity levels, and metabolic factors). Results: VAT% was significantly higher in Japanese and Koreans than in Japanese Americans and Caucasians (50.0, 48.5, 43.2, 41.0%, respectively, P < 0.001). Even after adjustment for possible confounders, the significant VAT% difference remained in comparing groups with identical race but different environments (i.e., Japanese vs. Japanese Americans). In contrast, comparing groups with different races but similar environments (i.e., Caucasians vs. Japanese Americans), VAT% was not significantly different. Comparing groups with similar races and similar environments (i.e., Japanese vs. Koreans), VAT% did not significantly differ. Conclusions: Environmental differences, apart from racial differences, affect the difference in abdominal fat distribution across different groups in middle-aged men.
  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究
    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ
    糖尿病 61 Suppl.1 S - 293 (一社)日本糖尿病学会 2018年04月
  • 赤身・加工肉摂取と心血管疾患死亡との関連は腎機能により異なるか? NIPPON DATA80
    瀬川 裕佳, 近藤 慶子, 山内 宏美, 大野 聖子, 田中 佐智子, 門田 文, 岡村 智教, 三浦 克之, 岡山 明, 上島 弘嗣, NIPPON DATA80研究グループ
    日本腎臓学会誌 60 3 353 - 353 (一社)日本腎臓学会 2018年04月
  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連
    近藤 慶子, 有馬 久富, 岡見 雪子, 安藤 朗, 藤吉 朗, 門田 文, 久松 隆史, 宮澤 伊都子, 森野 勝太郎, 前川 聡, 三浦 克之, 上島 弘嗣, 滋賀動脈硬化疫学研究(SESSA)グループ
    糖尿病 61 Suppl.1 S - 157 (一社)日本糖尿病学会 2018年04月
  • 日本人一般集団における血清N-3 polyunsaturated fatty acidと高感度C反応性蛋白の関連性(Association of Serum N-3 Polyunsaturated Fatty Acids and High-sensitivity C-reactive Protein in Japanese General Population)
    中村 翼, 門田 文, 近藤 慶子, 宮川 尚子, 関川 暁, 藤 吉朗, 久松 隆史, 三浦 克之, 上島 弘嗣
    日本循環器学会学術集会抄録集 82回 OJ24 - 7 2018年03月
  • 減塩への配慮状況と栄養素等摂取量との関連 NIPPON DATA2010
    岩橋 明子, 由田 克士, 荒井 裕介, 尾島 俊之, 藤吉 朗, 中川 秀昭, 奥田 奈賀子, 宮川 尚子, 門田 文, 岡村 智教, 大久保 孝義, 西 信雄, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本循環器病予防学会誌 53 1 37 - 47 (一社)日本循環器病予防学会 2018年03月 [無し][無し]
     
    【目的】高血圧は循環器疾患の危険因子であり、適正なエネルギー摂取や食塩摂取がその予防や治療に重要であることは広く知られている。一方で減塩への配慮状況とエネルギーや栄養素摂取量との関連を国レベルで詳細に検討した報告は限られている。そこで、減塩への配慮状況が実際の食塩や栄養素等摂取量とどのように関連するのか検討した。【方法】平成22年国民健康・栄養調査に参加し、NIPPON DATA2010への参加に同意した40〜74歳の1,875名を対象とした。性別に循環器疾患の既往(高血圧、脳卒中、心臓病、腎臓病)の有無と減塩に対する配慮の有無により分類し、エネルギー、栄養素、食塩摂取量の関係を比較した。【結果】循環器疾患の既往がある者は男性で325名(39.7%)、女性で286名(27.1%)であり、減塩配慮を行っている者の割合は、男性で367名(44.9%)、女性で583名(55.2%)であり、循環器疾患の既往と減塩配慮の有無に性差が認められた。男性の既往あり群では、減塩配慮あり群が減塩配慮なし群に比べ、ナトリウム摂取密度は少なかった(2,217±55:2,422±85(mg/1,000kcal/day)、p=0.020)。しかし、既往なし群では、減塩配慮あり群と減塩配慮なし群の間に同等の関係は認められなかった。女性では既往の有無に関わらず、何れの群間にもナトリウム摂取密度に差は認められなかった。しかし、Na/K比については、何れも減塩配慮あり群が有意に低値を示していた(既往あり2.92±0.87:3.26±0.13(mol/mol)、p=0.033既往なし2.81±0.57:3.18±0.57(mol/mol)、p<0.001)。【結論】男性では、循環器疾患の既往の有無が減塩配慮と実際の減塩行動とに関連していることが推測された。しかし、女性では既往の有無にかかわらず、差は認められなかった。循環器疾患の既往がない者に対しても、身近で減塩に関する正しい知識を会得できる機会を増やしていくことや、加工食品の低塩化など食品の環境的アプローチも同時に進めることが高血圧予防に必要であると考えられた。(著者抄録)
  • Ho N. Nguyen, Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Katsushi Yoshita, Yusuke Arai, Hideaki Nakagawa, Kiyomi Sakata, Toshiyuki Ojima, Aya Kadota, Naoyuki Takashima, Akira Fujiyoshi, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, NIPPON DATA80 Research Group
    Clinical Nutrition 37 1 182 - 188 2018年02月 [有り][無し]
     研究論文(学術雑誌) 
    Background & aim: Although dietary soy intake is linked with health benefits, a relation with stroke has not been established. The present study examined the association between the intake of tofu, the richest source of dietary soy, with stroke mortality in a general population cohort of Japanese men and women. Methods: Data comprise 9244 Japanese enrolled in the National Nutrition Survey of Japan in 1980. Participants were free of cardiovascular disease and followed for 24 years. Dietary intake was estimated from 3-day weighed food records. Multivariable Cox regression models were used to estimate hazard ratios across levels of tofu intake. Results: During follow-up, there were 417 deaths due to stroke (88 cerebral hemorrhage [CH], 245 cerebral infarction [CI], and 84 of other subtypes). Among all men, and in women aged 65 years or more, tofu intake was unrelated to each form of stroke. For young women (< 65 years of age), a significantly lower risk of CH in the top versus bottom quartile of tofu intake was observed (Multivariable-adjusted HR = 0.26, 95% CI: 0.08–0.85). Conclusions: In this large prospective study with long follow-up of Japanese men and women, consumption of tofu was unrelated to the risk of stroke except for CH in women < 65 years of age. Whether the association in younger women is real or due to chance alone warrants further study.
  • Sentaro Suzuki, Hisatomi Arima, Soichiro Miyazaki, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Takashi Hisamatsu, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Minoru Horie, Kiyoshi Murata, Katsuyuki Miura, Hirotsugu Ueshima
    Journal of Atherosclerosis and Thrombosis 25 2 186 - 198 2018年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men. Methods: This was a cross-sectional survey of 1093 randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire CAC by computed tomography and carotid IMT by ultrasonography. Results: The prevalence of CAC was 50.0% for participants with sleep duration<5.5 h, 43.9% with 5.5 – 6.4 h, 50.0% with 6.5 –7.4 h, 49.3% with 7.5–8.4 h, and 62.5% with ≥8.5 h. In univariate analysis, participants with sleep duration ≥8.5 h had significantly higher prevalence of CAC than those with 6.5–7.4 h (p=0.043). After adjustment for age and other risk factors, however, the association was not significant (p=0.776). The average IMT was 0.85 mm for participants with sleep duration<5.5 h, 0.83 mm with 5.5–6.4 h, 0.85 mm with 6.5–7.4 h, 0.88 mm with 7.5–8.4 h, and 0.90 mm with ≥ 8.5 h. None of the differences in IMT observed in crude or multivariable-adjusted analyses was significant (all p>0.1). Conclusion: Self-reported sleep duration was not associated with increased CAC or carotid IMT in a general population of Japanese men.
  • Nakamura T, Nakamura Y, Saitoh S, Okamura T, Yanagita M, Yoshita K, Kita Y, Murakami Y, Yokomichi H, Nishi N, Okuda N, Kadota A, Ohkubo T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S10 - S16 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Socioeconomic status (SES) imbalances in developed and developing countries may result in individuals being overweight and obese. However, few studies have investigated this issue in Japan. We herein examined the relationship between SES and being underweight, overweight or obese according to sex and age groups (20-64 or ≥65 years) in Japan. METHODS: In 2010, we established a cohort of participants in the National Health and Nutrition Survey of Japan. We divided 2,491 participants (1,081 men and 1,410 women) according to the WHO definitions of underweight, overweight or obesity and performed multinomial logistic analyses using BMI <18.5 kg/m2 (underweight), BMI 25.0-29.9 kg/m2 (overweight), and BMI ≥30.0 kg/m2 (obese) versus BMI 18.5-24.9 kg/m2 (normal) as the outcome, with SES groups as the main explanatory variables. RESULTS: In adult men, a lower education level relative to a higher education level was inversely associated with obesity after adjustments for other SESs (odds ratio [OR] 0.41; 95% confidence interval [CI], 0.18-0.96). However, in adult women, lower education level was positively associated with being overweight and obese (OR 1.67; 95% CI, 1.07-2.49 for overweight and OR 2.66; 95% CI, 1.01-7.01 for obese). In adult women, a lower household income was positively associated with being overweight and obese (obese: OR 4.84; 95% CI, 1.36-17.18 for those with a household income <2 million JPY relative to those with ≥6 million JPY). CONCLUSIONS: In adult women, a lower education level and lower household income were positively associated with being overweight or obese. In contrast, in adult men, a lower education level was inversely associated with obesity. Gender and age differences in SESs affect the prevalence of being overweight or obese.
  • Sakurai M, Nakagawa H, Kadota A, Yoshita K, Nakamura Y, Okuda N, Nishi N, Miyamoto Y, Arima H, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S17 - S22 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: This study examined the relationships among household income, other SES indicators, and macronutrient intake in a cross-sectional study of a representative Japanese population. METHODS: In 2010, we established a cohort of participants in the National Health and Nutrition Survey (NHNS) from 300 randomly selected areas throughout Japan. A total of 2,637 participants (1,145 men and 1,492 women) were included in the study. Data from NHNS2010 and the Comprehensive Survey of Living Conditions 2010 (CSCL2010) were merged, and relationships among macronutrient intake and SES were evaluated. Additionally, socioeconomic factors associated with a risk of a higher carbohydrate/lower fat intake beyond dietary recommendations were evaluated. RESULTS: Household income was positively associated with fat intake (P = 0.001 for men and <0.001 for women) and inversely associated with carbohydrate intake (P = 0.003 for men and <0.001 for women) after adjustments for age and other SES variables. Similar relationships were observed between equivalent household expenditure (EHE) and macronutrient intake; however, these relationships were weaker than those of household income. Older age was the factor most strongly associated with a high carbohydrate/low fat intake, followed by household income, EHE, education levels, and occupation type. CONCLUSIONS: Older age was the factor most strongly associated with a high carbohydrate/low fat intake, and some aspects of SES, such as household income, EHE, education levels, and occupation type, were independently associated with an imbalanced macronutrient intake. SES may affect the health status of individuals through the intake of macronutrients.
  • Kadota A, Okuda N, Ohkubo T, Okamura T, Nishi N, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S2 - S9 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: The structure and risk factors for cardiovascular diseases (CVD) in Japan may change because lifestyle, particularly nutrition, socioeconomic status, and medical care, which affect CVD, may markedly change over time. Therefore, a new prospective cohort study on a representative general Japanese population based on national surveys is required. METHODS: In November 2010, the baseline survey of the National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010) was performed with the National Health and Nutrition Survey of Japan (NHNS2010) in 300 randomly selected districts throughout Japan. The survey included a questionnaire, electrocardiogram, urinalysis, and blood biomarkers added to the NHNS2010 examinations. Physical measurements, blood biomarkers, and dietary data were also obtained in NHNS2010. Socioeconomic factors were obtained by merging with the Comprehensive Survey of Living Conditions 2010 (CSLC2010) dataset. Participants are followed annually for the incidence of diabetes mellitus, CVD events (acute coronary events, heart failure, atrial fibrillation, and stroke), and cause-specific mortality. The activities of daily living are followed every 5 years. RESULTS: A total of 2,898 individuals aged 20 years or older agreed to participate in the baseline survey of NIPPON DATA2010. The participation rate was 74.6%. Of these, data from NHNS2010 was merged for 2,891 participants (1,236 men and 1,655 women). The data of 2,807 participants were also merged with CSLC2010 data. CONCLUSIONS: We established NIPPON DATA2010 as a cohort study on a representative general Japanese population that covers all of Japan.
  • Nagahata T, Nakamura M, Ojima T, Kondo I, Ninomiya T, Yoshita K, Arai Y, Ohkubo T, Murakami K, Nishi N, Murakami Y, Takashima N, Okuda N, Kadota A, Miyagawa N, Kondo K, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S23 - S28 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: A lower socioeconomic status (SES) may be related to the intake of unhealthy food; however, this relationship has not been examined in detail. This study was undertaken to examine relationships among food group intakes and SES in a representative Japanese population. METHODS: This was a cross-sectional study using the baseline data of NIPPON DATA2010, which is a prospective cohort study of the National Health and Nutrition Survey in Japan. A total of 2,898 participants were included in the baseline survey in 2010. The effects of age (<65 years and ≥65 years), equivalent household expenditure (EHE), and education attainment on food group intakes (gram per 1,000 kcal) were analyzed using a two-way analysis of variance. RESULTS: When EHE was lower, cereal intake was higher in men and women. Among men, fish, milk, and alcohol intakes were reduced with lower EHE. Among women, vegetable intake was reduced with lower EHE. In men and women, cereal intake was higher with lower education attainment. In contrast, meat intake was reduced with lower education attainment. CONCLUSIONS: Lower SES was associated with a higher cereal intake and lower vegetable, fish, meat, and milk intakes in a representative Japanese population. Socioeconomic discrepancies need to be considered in order to promote healthier dietary habits.
  • Miyagawa N, Okuda N, Nakagawa H, Takezaki T, Nishi N, Takashima N, Fujiyoshi A, Ohkubo T, Kadota A, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S29 - S34 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Although socioeconomic status (SES) may affect food and nutrient intakes, few studies have reported on sodium (Na) and potassium (K) intakes among individuals with various SESs in Japan. We investigated associations of SES with Na and K intake levels using urinary specimens in a representative Japanese population. METHODS: This was a cross-sectional study of 2,560 men and women (the NIPPON DATA2010 cohort) who participated in the National Health and Nutrition Survey Japan in 2010. Casual urine was used to calculate estimated excretion in 24-hour urinary Na (E24hr-Na) and K (E24hr-K). The urinary sodium-to-potassium (Na/K) ratio was calculated from casual urinary electrolyte values. An analysis of covariance was performed to investigate associations of aspects of SES, including equivalent household expenditure (EHE), educational attainment, and job category, with E24hr-Na, E24hr-K, and the Na/K ratio for men and women separately. A stratified analysis was performed on educational attainment and the job category for younger (<65 years) and older (≥65 years) participants. RESULTS: In men and women, average E24hr-Na was 176.2 mmol/day and 172.3, average E24hr-K was 42.5 and 41.3, and the average Na/K ratio was 3.61 and 3.68, respectively. Lower EHE was associated with a higher Na/K ratio in women and lower E24hr-K in men and women. A shorter education was associated with a higher Na/K ratio in women and younger men, and lower E24hr-K in older men and women. CONCLUSION: Lower EHE and a shorter education were associated with a lower K intake and higher Na/K ratio estimated from casual urine specimens in Japanese men and women.
  • Goryoda S, Nishi N, Hozawa A, Yoshita K, Arai Y, Kondo K, Miyagawa N, Hayakawa T, Fujiyoshi A, Kadota A, Ohkubo T, Okamura T, Okuda N, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S35 - S39 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: The relationships among socioeconomic status and lifestyle improvements have not yet been examined in a representative Japanese population. METHODS: We analyzed data from 2,647 participants (1,087 men and 1,560 women) who participated in NIPPON DATA2010. This survey inquired about lifestyle improvements and socioeconomic status. Education was categorized as low (≤9 years), middle (10-12 years), and high (≥13 years). Marital status was categorized as married, divorced, widowed, and never married/other. A multivariable logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of lifestyle improvements with the intention of preventing cardiovascular diseases for educational attainment and marital status, with adjustments for age and awareness of cardiovascular disease risk factors. RESULTS: Overall, 1,507 (56.9%) participants practiced prevention and improvements in hypertension, diabetes, elevated cholesterol, and metabolic syndrome, and the OR of lifestyle improvements was significantly higher with a high education than with a low education in men (OR 2.86; 95% CI, 1.96-4.17) and women (OR 2.36; 95% CI, 1.67-3.33). The number of participants who practiced prevention and improvements in hypertension, diabetes, elevated cholesterol, and metabolic syndrome was significantly lower in divorced than in married men (OR 0.46; 95% CI, 0.22-0.95) and women (OR 0.53; 95% CI, 0.33-0.86). CONCLUSIONS: Specific differences caused by educational attainment and marital status may exist in lifestyle improvements.
  • Nguyen M, Nishi N, Kadota A, Okuda N, Arima H, Fujiyoshi A, Nakano Y, Ohkubo T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 Supplement_III S40 - S45 2018年 [有り][無し]
     研究論文(学術雑誌)
  • Tsuji M, Arima H, Ohkubo T, Nakamura K, Takezaki T, Sakata K, Okuda N, Nishi N, Kadota A, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S46 - S52 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: The relationship between socioeconomic status (SES) and knowledge of cardiovascular risk factors remains unknown in a general Japanese population. METHODS: Of 8,815 participants from 300 randomly selected areas throughout Japan, 2,467 participants who were free of cardiovascular disease and who provided information on SES in the National Health and Nutrition Survey of Japan 2010 were enrolled in this cross-sectional analysis. SES was classified according to the employment status, length of education, marital and living statuses, and equivalent household expenditure (EHE). Outcomes were ignorance of each cardiovascular risk factor (hypertension, diabetes, hypercholesterolemia, low high-density lipoprotein [HDL] cholesterol, arrhythmia, and smoking) and insufficient knowledge (number of correct answers <4 out of 6). RESULTS: A short education and low EHE were significantly associated with a greater ignorance of most cardiovascular risk factors. A short education (<10 years) was also associated with insufficient knowledge of overall cardiovascular risk factors: age- and sex-adjusted odds ratios (OR) were 1.92 (95% confidence interval [CI], 1.51-2.45) relative to participants with ≥13 years of education. Low EHE was also associated with insufficient knowledge (age- and sex-adjusted OR 1.24; 95% CI, 1.01-1.51 for the lowest quintile vs the upper 4 quintiles). These relationships remained significant, even after further adjustments for regular exercise, smoking, weekly alcohol consumption, body mass index, hypertension, diabetes mellitus, hypercholesterolemia, and low HDL cholesterol. CONCLUSION: Participants with a short education and low EHE were more likely to have less knowledge of cardiovascular risk factors.
  • Imamura H, Kogure M, Kita Y, Nakagawa H, Hozawa A, Okamura T, Murakami Y, Nishi N, Okuda N, Kadota A, Ohkubo T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S53 - S58 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: This study investigated relationships among socioeconomic factors and participation in health examinations for Japanese National Health Insurance (NHI) using a representative Japanese population. METHODS: We used the linkage database of NIPPON DATA2010 and Comprehensive Survey of Living Conditions 2010. Participants with NHI aged 40-74 years were included in the analysis. Prevalence ratios (PRs) for participation in health examinations in the past year were set as an outcome. Participant characteristics, including sex, age, socioeconomic factors (educational attainment, employment, equivalent household expenditure [EHE], house ownership, and marital status), laboratory measures, and lifestyle were included in an age-stratified modified Poisson regression analysis to examine relationships. RESULTS: The number of study participants was 812, and 564 (69.5%) participated in health examinations in the past year. Among those aged 40-64 years, there was no significant PR for socioeconomic factors. Among those aged 65-74 years, high (≥13 years) educational attainment (adjusted PR, 1.22; 95% confidence interval [CI], 1.05-1.41) and house ownership (PR 1.40; 95% CI, 1.11-1.77) were positively associated with participation, while high (4th quartile) EHE (PR 0.84; 95% CI, 0.73-0.97) was negatively associated. CONCLUSION: These results suggest that high educational attainment, house ownership, and low EHE were positive factors for participation in health examinations among those aged 65-74 years.
  • Murakami K, Ohkubo T, Nakamura M, Ninomiya T, Ojima T, Shirai K, Nagahata T, Kadota A, Okuda N, Nishi N, Okamura T, Ueshima H, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S59 - S65 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Most studies on socioeconomic inequalities in oral health have not considered the effects of behavioral and biological factors and age differences. Furthermore, the nationwide status of inequalities remains unclear in Japan. METHODS: We analyzed data from 2,089 residents aged ≥40 years throughout Japan. The lowest quartile of the number of remaining teeth for each 10-year age category was defined as poor oral health. Behavioral and biological factors included smoking status, obesity, diabetes mellitus, high-sensitivity C-reactive protein, and the use of dental devices. Multiple logistic regression analyses were conducted to examine the associations of educational attainment and equivalent household expenditure (EHE) with oral health, and stratified analyses by age category were also conducted (40-64 years and ≥65 years). RESULTS: Lower education and lower EHE were significantly associated with an increased risk of poor oral health after adjusting for age, sex, employment status, marital and living statuses, and EHE/education; the odds ratio for junior high school education compared with ≥college education was 1.84 (95% confidence interval [CI], 1.36-2.49), and the odds ratio of the lowest compared with the highest EHE quartile was 1.91 (95% CI, 1.43-2.56). Further adjustments for behavioral and biological factors attenuated but did not eliminate these associations. EHE was significantly associated with oral health among elderly adults only, with a significant interaction by age category. CONCLUSIONS: Those with a lower education and those with lower EHE had a significantly higher risk of poor oral health, even after adjustments for behavioral and biological factors.
  • Ota A, Yatsuya H, Nishi N, Okuda N, Ohkubo T, Hayakawa T, Kadota A, Okayama A, Miura K
    Journal of epidemiology 28 Suppl 3 S66 - S72 2018年 [有り][無し]
  • Itsuko Miyazawa, Aya Kadota, Katsuyuki Miura, Motozumi Okamoto, Takashi Nakamura, Tsuyoshi Ikai, Hiroshi Maegawa, Atsushi Ohnishi
    Endocrine Journal 65 5 527 - 536 2018年 [有り][無し]
     研究論文(学術雑誌) 
    The prevalence of obesity is increasing globally in patients with diabetes. This study aimed to examine 12-year trends of increasing obesity in Japanese patients with diabetes, and their clinical features. The study used results of the Shiga Diabetes Clinical Survey, which recorded medical performance in diabetic patients in 2000, 2006 and 2012. Data were analyzed from 14,205, 14,407 and 21,449 adult patients in these three years, respectively. Overweight and obesity prevalence and the clinical features of diabetes patients were examined, stratified by body mass index (BMI) and age. The prevalence of overweight (BMI 25–30 kg/m2) and obesity (BMI ≥30 kg/m2) were 27.0% and 5.1% in 2000, 28.9% and 7.3% in 2006 and 30.9% and 10.0% in 2012. Glycemic control, blood pressure and serum lipid profile improved over 12 years in all BMI categories. However, glycemic and triglyceride control were insufficient in obese patients aged < 65 years (hemoglobin A1c 7.5 ± 1.4%, triglyceride 197.7 ± 178.4 mg/dL in 2012). The percentage of patients who used antihypertensive and lipid-lowering drugs increased and patients with higher BMI had increased frequency of using these drugs, both in young and old age groups. Higher BMI was significantly and positively associated with albuminuria. In summary, overweight and obesity have increased in Japanese diabetic patients, particularly for younger generations. Findings suggest that obesity may lead to poorer glycemic control, blood pressure and lipid profiles. Overweight and obesity are important modifiable risk factors for diabetes, suggesting that more active weight-control interventions are warranted.
  • 宮澤 伊都子, 三浦 克之, 宮本 恵宏, 岡村 智教, 東山 綾, 辰巳 友佳子, 門田 文, 高嶋 直敬, 宮川 尚子, 近藤 慶子, 佐藤 敦, 有馬 久富, 岡山 明, 上島 弘嗣, NIPPON DATA, 研究グループ
    日本循環器病予防学会誌 52 3 269 - 278 (一社)日本循環器病予防学会 2017年12月 [無し][無し]
     
    【背景】我が国では、2008年より特定健診が開始され、肥満を必須とするメタボリックシンドローム該当者に対する保健指導介入が行われている。残る非肥満に対する有効な介入方法が模索されているが、肥満、非肥満別に循環器疾患危険因子による循環器疾患死亡の集団寄与危険割合を検討した報告は少ない。【目的】循環器疾患危険因子(血圧、血糖、喫煙)による循環器疾患死亡の集団寄与危険割合(Population Attributable Fraction:PAF)を非肥満群、肥満群に分けて検討する。【方法】対象は1980年に実施された循環器疾患基礎調査の受検者を29年間追跡したNIPPON DATA80対象者のうち、40歳〜74歳の男女計6,662人である。肥満の有無と循環器疾患危険因子のカテゴリーを組み合わせて対象者を分類し、"非肥満かつ循環器疾患危険因子正常群"に対する、各群の多変量調整ハザード比とPAFを算出した。PAFはより現在に近い2010年の危険因子の分布でも算出し、1980年との比較を行った。【結果】循環器疾患死亡に対する多変量調整ハザード比(95%信頼区間)は、血圧は正常、正常高値、高血圧1度、高血圧2度以上と上昇するに従い、非肥満群、肥満群ともに上昇を認めた(非肥満かつ高血圧2度以上群:2.10(1.64-2.70)、肥満かつ高血圧2度以上群:2.72(1.95-3.80)。血糖は正常(随時血糖140mg/dl未満)、境界型(140-200mg/dl)、糖尿病域(200mg/dl以上)と上昇するに従い、非肥満群、肥満群ともに上昇を認めた(非肥満かつ糖尿病域群:2.01(1.33-3.03)、肥満かつ糖尿病域群5.08(2.98-8.66)。喫煙は非喫煙、過去喫煙、現在喫煙(≦20本/日、≦21本/日)の順に上昇を認めた(非肥満かつ現在喫煙≦21本/日群:1.94(1.47-2.55)、肥満かつ現在喫煙≧21本/日群:1.98(1.24-3.15)。2010年の危険因子分布を用いた血圧のPAF合計は非肥満群37.2%、肥満群21.7%、血糖のPAF合計は非肥満群14.4%、肥満群16.3%、喫煙のPAF合計は非肥満群7.0%、肥満群0.9%と、いずれにおいても非肥満群のPAFは肥満群と同等もしくは高値を示した。【結論】各種循環器疾患危険因子は非肥満群、肥満群のどちらにおいても循環器疾患死亡リスクと関連していた。PAFは非肥満群の方が肥満群よりも大きい傾向であり、非肥満者に対しても循環器疾患危険因子に対する介入が重要であることが示唆された。(著者抄録)
  • 日本人男性の地域在住被験者における喫煙と関連する冠動脈硬化性の高発症率および進行度 The Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Smoking associates with higher incidence and progression of coronary atherosclerosis in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))
    Pham Tai, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Kadowaki Sayaka, Zaid Maryam, Horie Minoru, Miura Katsuyuki, Ueshima Hirotsugu, for the SESSA Research Group
    日本アルコール・薬物医学会雑誌 52 4 239 - 239 2017年08月
  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係
    近藤 慶子, 有馬 久富, 久松 隆史, 藤吉 朗, 門田 文, 関川 暁, 鳥居 さゆ希, 鈴木 仙太朗, 椎野 顯彦, 野崎 和彦, 宮川 尚子, 前川 聡, 村田 喜代史, 三浦 克之, 上島 弘嗣
    日本動脈硬化学会総会プログラム・抄録集 49回 195 - 195 (一社)日本動脈硬化学会 2017年06月
  • 客観的に評価された歩数値とメタボリックシンドローム発症との関連 地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)
    久松 隆史, 三浦 克之, 渋川 武志, 藤吉 朗, 有馬 久富, 門田 文, 宮川 尚子, 鳥居 さゆ希, 近藤 慶子, 宮澤 伊都子, 鈴木 仙太朗, 佐藤 敦, 山添 正博, 柳田 昌彦, 前川 聡, 上島 弘嗣
    日本循環器病予防学会誌 52 1 20 - 28 (一社)日本循環器病予防学会 2017年03月 [無し][無し]
     
    【背景】客観的に評価された身体活動量がメタボリックシンドローム(MetS)発症リスクと関連するかどうか検討した研究はほとんどない。【目的】日本人一般住民男性において、歩数計を用いて評価された歩数値とMetS新規発症との関連を縦断的に検討すること。【方法】滋賀県草津市住民から無作為抽出された40-79歳男性のうちMetSを有さない525名(平均年齢64.1±9.6歳)を対象とし、5年間の前向きコホート研究(基礎調査2006-8年)を実施した。歩数は基礎調査時に土・日曜日を含む7日間連続で歩数計を用いて測定し1日平均値を求めた。MetS発症の診断は日本基準を用いて評価した。ロジスティック回帰を用いてMetS新規発症に対する歩数値に関する多変量調整相対リスク(RR)および95%信頼区間(CI)を算出した。【結果】平均追跡期間4.8±1.3年を経て、MetS新規発症者は77名(14.7%)であった。Body mass indexを含む交絡因子を調整後も歩数値とMetS発症との間に負の関連を認めた。この関連はMetS各構成要素でさらに調整しても変わらなかった(最低三分位群[5,792歩未満]と比較して、最高三分位群[10,033歩以上]のMetS発症に対するRR(95%CI)は0.34[0.17-0.72])。また、MetS発症に対する1日平均1,000歩増加あたりのRR(95%CI)は、0.87(0.78-0.96)であった。65歳未満・以上、MetS各構成要素の有無で層別に解析したが同様の傾向を認めた(全異質性P値>0.3)。【結語】MetSの好発集団とされる一般中高年男性において、客観的に評価された歩数値はMetS発症と有意な負の関連を示した。また、1日平均歩数値1,000歩増加あたりMetS発症リスクが13%低下した。本成果は健康日本21(第二次)の歩数目標値や身体活動基準2013を支持する結果である。(著者抄録)
  • Aya Hirata, Tomonori Okamura, Daisuke Sugiyama, Kazuyo Kuwabara, Aya Kadota, Akira Fujiyoshi, Katsuyuki Miura, Nagako Okuda, Takayoshi Ohkubo, Akira Okayama, Hirotsugu Ueshima
    EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 24 5 505 - 513 2017年03月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in a general population is uncertain. Methods: We followed 7229 participants (age: >= 30 years) with no history of CVD in a Japanese community. We divided participants into four categories according to CKD and/or DM and calculated hazard ratios (HRs) of CVD mortality for each category using a Cox proportional hazards model adjusted for age, dyslipidemia, smoking and alcohol consumption. In addition, PAFs of CVD were estimated among populations with CKD and/or DM. Results: During 20-year follow-up, 488 participants died. HRs for CVD were 1.63 [ 95% confidence interval (CI): 1.16-2.30] with DM only, 1.42 (95% CI: 1.08-1.86) with CKD only and 2.37 (95% CI: 1.40-4.01) with CKD+DM. In men, the corresponding HRs for CVD were 1.88 (95% CI: 1.19-2.97), 1.71 (95% CI: 1.15-2.56) and 3.26 (95% CI: 1.69-6.30), respectively; the corresponding PAFs of CVD were 4.1%, 5.1% and 2.9%, respectively. PAFs for CVD among women were lower than those in men, 1.6% for DM only, 2.0% for CKD only and 0.7% for CKD+DM. Conclusions: PAFs of CVD mortality due to CKD and/or DM were not so high in past 20 years; however, they might increase in the future because of recent increase in prevalence of these in Japanese population.
  • Atsushi Satoh, Hisatomi Arima, Takayoshi Ohkubo, Nobuo Nishi, Nagako Okuda, Ryusuke Ae, Mariko Inoue, Shuji Kurita, Keiko Murakami, Aya Kadota, Akira Fujiyoshi, Kiyomi Sakata, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
    JOURNAL OF HYPERTENSION 35 2 401 - 408 2017年02月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To investigate associations between socioeconomic status (SES) and prevalence, awareness, treatment, and control of hypertension in Japan's general population. Methods: In 2010, we established a cohort of participants in the National Health and Nutrition Survey of Japan. The cohort included 2623 adults from 300 randomly selected areas across Japan. Using baseline data, four cross-sectional analyses were performed: association of SES with prevalent hypertension in 2623 participants; association of SES with unawareness of hypertension and with no treatment in 1282 hypertensive patients; and association of SES with uncontrolled hypertension in 720 treated hypertensive patients. SES was classified according to employment status, length of education, marital and living status, and household expenditure. Results: The overall prevalence of hypertension was 48.9%. Among hypertensive participants, the proportions of unawareness and no treatment were 33.1 and 43.8%, respectively. Target blood pressure levels were not achieved among 61.2% of treated hypertensive patients. Hypertension was more prevalent in the unmarried and living alone group than in the married group (odds ratio 1.76; 95% confidence interval 1.26-2.44), after adjustment for age, sex, BMI, smoking, alcohol consumption, habitual exercise, history of cardiovascular diseases, diabetes mellitus, hypercholesterolemia, dietary sodium, and potassium intake. SES was not clearly associated with unawareness, no treatment, nor poor control of hypertension. Conclusion: Being unmarried and living alone was associated with increased prevalence of hypertension. There was no clear association of SES with unaware, untreated, and uncontrolled hypertension.
  • 三大栄養素摂取量と社会経済学的要因の検討
    櫻井 勝, 中川秀昭, 門田 文, 由田克士, 中村保幸, 奥田奈賀子, 西 信雄, 宮本恵宏, 有馬久富, 大久保孝義, 岡村智教, 上島弘嗣, 岡山 明, 三浦克之
    NIPPON DATA2010. 厚生労働行政推進調査事業費補助金(循環器疾患・糖尿病等生活習慣病対策総合研究事業)社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度総括・分担研究報告書(研究代表者 三浦克之) - 61 - 64 2017年 [無し][無し]
  • Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Abhisek Vishnu, Aya Kadota, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Rhobert W. Evans, Bradley J. Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa
    JOURNAL OF HYPERTENSION 35 1 111 - 117 2017年01月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: A few studies have examined the longitudinal association of blood pressure (BP) with arterial stiffness progression, and the results were inconsistent. The objective of this study was to investigate the roles of initial BP and its longitudinal change on the progression of arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV). Method: Study participants (n = 656) were from population-based samples of healthy men aged 40-49 years at baseline (213 White Americans, 47 AfricanAmericans, 152 Japanese Americans and 244 Japanese in Japan). BP measures, baPWV and other factors were examined at baseline and 4-7 years later. General linear regression was applied for statistical analyses. Result: Annual change in SBP (standardized coefficient: 0.33, P<0.001), but not its baseline level (standardized coefficient: 0.03, P = 0.495), had a positive significant association with the progression of baPWV after adjusting for a wide range of standard cardiovascular risk factors. Similarly, annual changes in DBP (standardized coefficient: 0.35, P<0.001), pulse pressure (standardized coefficient: 0.15, P = 0.001) and mean arterial pressure (standardized coefficient: 0.37, P<0.001) were positively associated with the progression of baPWV. None of the baseline measures were related to the progression of baPWV. Conclusion: Our findings imply that, regardless of initial BP, effective monitoring and controlling of BP is important to slow down arterial wall stiffening and hence reduce cardiovascular risk.
  • Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa
    HYPERTENSION 69 1 102 - 108 2017年01月 [有り][無し]
     研究論文(学術雑誌) 
    Arterial stiffness is established as an independent predictor of cardiovascular morbidity and mortality. The objective was to prospectively evaluate association of aortic calcification burden with progression of arterial stiffness in population-based samples of healthy middle-aged men from ERA JUMP cohort (Electron-Beam Computed Tomography and Risk Factor Assessment in Japanese and US Men in the Post-World War II Birth Cohort). Men (n=635) aged 40 to 49 years (207 white American, 45 black American, 142 Japanese American, and 241 Japanese in Japan) were examined at baseline and 4 to 7 years later. Aortic calcification was evaluated from level of aortic arch to iliac bifurcation. Arterial stiffness progression was measured as annual change in brachial-ankle pulse wave velocity. Multivariable-adjusted general linear models were applied to investigate associations of longitudinal change in aortic calcification with arterial stiffness progression in participants overall, as well as in subgroups without or with prevalent aortic calcification at baseline. Annual change in aortic calcification was positively and significantly associated with arterial stiffness progression. In participants with annual changes in aortic calcium score of 0, 1 to 10, 11 to 100, and >100, the adjusted means (SD) for the annual change in brachial-ankle pulse wave velocity were 3.8 (2.2), 7.2 (2.2), 12.2 (1.8), and 15.6 (2.6) cm/s, respectively (P for trend <0.01) adjusted for baseline aortic calcification, arterial stiffness, and standard cardiovascular risk factors. Arterial stiffness was associated with the incidence of aortic calcification over the follow-up period among participants without aortic calcification (n=297) and with an increase in aortic calcification among participants with prevalent aortic calcification at baseline (n=388). Our findings suggest aortic calcification may be causally linked to arterial stiffness.
  • Maryam Zaid, Akira Fujiyoshi, Aya Kadota, Robert D. Abbott, Katsuyuki Miura
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 24 3 227 - 239 2017年 [有り][無し]
     
    Atherosclerosis begins in early life and has a long latent period prior to onset of clinical disease. Measures of subclinical atherosclerosis, therefore, may have important implications for research and clinical practice of atherosclerotic cardiovascular disease (ASCVD). In this review, we focus on coronary artery calcium (CAC) and carotid artery intima-media thickness (cIMT) and plaque as many population-based studies have investigated these measures due to their non-invasive features and ease of administration. To date, a vast majority of studies have been conducted in the US and European countries, in which both CAC and cIMT/plaque have been shown to be associated with future risk of ASCVD, independent of conventional risk factors. Furthermore, these measures improve risk prediction when added to a global risk prediction model, such as the Framingham risk score. However, no clinical trial has assessed whether screening with CAC or cIMT/plaque will lead to improved clinical outcomes and healthcare costs. Interestingly, similar levels of CAC or cIMT/plaque among various regions and ethnic groups may in fact be associated with significantly different levels of absolute risk of ASCVD. Therefore, it remains to be determined whether measures of subclinical atherosclerosis improve risk prediction in non-US/European populations. Although CAC and cIMT/plaque are promising surrogates of ASCVD in research, we conclude that their use in clinical practice, especially as screening tools for primary prevention in asymptomatic adults, is premature due to many vagaries that remain to be clarified.
  • Vasudha Ahuja, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert Evans, Maryam Zaid, Naoko Miyagawa, Takashi Hisamatsu, Aya Kadota, Tomonori Okamura, Hirotsugu Ueshima, Akira Sekikawa
    BRITISH JOURNAL OF NUTRITION 117 2 260 - 266 2017年01月 [有り][無し]
     研究論文(学術雑誌) 
    Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40-49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol >83 nm. The presence of CAC was defined as a coronary Ca score 10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 5127 (interquartile range (IQR) 1941, 11700), 91 (IQR 010, 331) and 00 (IQR 00, 10) nm, respectively. Prevalence of CAC and equol-producers was 96 and 160 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 010 (95 % CI 001, 090, P<004). Equol-producers had significantly lower CAC than equol non-producers, but there was no significant association between dietary isoflavones and CAC, suggesting that equol may be a key factor for atheroprotective properties of isoflavones in Japanese men. This finding must be confirmed in larger studies or clinical trials of equol that is now available as a dietary supplement.
  • Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Wakiko Takeshita, Komei Iwai, Yoshiyuki Watanabe, Masahiro Nakatochi, Chisato Shimanoe, Keitaro Tanaka, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Sayo Kawai, Tae Sasakabe, Rieko Okada, Asahi Hishida, Mariko Naito, Kiyonori Kuriki, Kaori Endoh, Norihiro Furusyo, Hiroaki Ikezaki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko Nakamura, Michiaki Kubo, Kenji Wakai
    Journal of Atherosclerosis and Thrombosis 24 12 1267 - 1281 2017年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions. Methods: Using cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study in the baseline surveys, 14,087 participants from 12 research areas were genotyped. We conducted a hypothesis-based association between stroke prevalence and SNPs in the RAMP2 and CLR genes based on data abstracted from two SNPs in RAMP2 and 369 SNPs in CLR. We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis. Results: Five of the SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with obesity, ischemic heart disease, hypertension, dyslipidemia, and diabetes. In the logistic regression analysis, rs574603859 had a lower odds ratio (0.238 95% confidence interval, 0.076-0.745, adjusted for age, sex, and research area) and the other SNPs had higher odds ratios for association with stroke. Conclusions: This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human.
  • 大橋 瑞紀, 宮川 尚子, 藤吉 朗, 高嶋 直敬, 三浦 克之, 門田 文, 上島 弘嗣, 中村 好一, 永井 雅人, 柳田 昌彦, 宮本 恵宏, 森 満, 西 信雄, 宮地 元彦, 奥田 奈賀子, 大久保 孝義, 喜多 義邦, 岡村 智教, 岡山 明
    厚生の指標 63 15 1 - 7 厚生労働統計協会 2016年12月 [無し][無し]
  • Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Koichiro Azuma, Sachiko Tanaka, Takashi Hisamatsu, Hisatomi Arima, Aya Kadota, Naoko Miyagawa, Naoyuki Takashima, Takayoshi Ohkubo, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima
    Preventive medicine reports 4 225 - 32 2016年12月 [有り][無し]
     研究論文(学術雑誌) 
    Studies from Western countries suggest that smokers tend to display greater abdominal obesity than non-smokers, despite showing lower weight. Whether this holds true in a leaner population requires clarification. Using indices of abdominal obesity including visceral adipose tissue, we examined whether lifetime cigarette smoking is associated with unfavorable fat distribution among Japanese men. From 2006 to 2008, we conducted a cross-sectional investigation of a community-based sample of Japanese men at 40-64 years old, free of cardiovascular diseases and cancer. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography. We divided participants into four groups: never-smokers; and tertiles of pack-years of smoking among ever-smokers. Using multivariable linear regression, we calculated adjusted means of obesity indices (VAT, SAT, VAT-SAT ratio [VSR], and waist-hip ratio [WHR]) for each group, and mean differences between consecutive groups. We analyzed 513 men (median age, 58.2 years; current smokers, 40.1%). Two-thirds showed body mass index (BMI) < 25 kg/m(2) (median, 23.5 kg/m(2)). Overall, greater lifetime smoking group was associated with greater WHR and VSR. On average, one higher smoking group was associated with 0.005 higher WHR (95% CI, 0.001-0.008; P = 0.005) and 0.041 greater VSR (95% CI, 0.009-0.073; P = 0.012) after adjustment for potential confounders, including BMI. In this sample of relatively lean Japanese men, greater lifetime smoking was associated with a metabolically more adverse fat distribution. Although smoking is commonly associated with lower BMI, minimizing the amount of lifetime smoking should be advocated.
  • 一般国民における循環器疾患危険因子の認知度および危険因子保有と認知度との関連 NIPPON DATA2010
    永井 雅人, 大久保 孝義, 門田 文, 宮川 尚子, 村上 義孝, 高嶋 直敬, 奥田 奈賀子, 東山 綾, 早川 岳人, 藤吉 朗, 中村 好一, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 51 3 166 - 175 (一社)日本循環器病予防学会 2016年11月 [無し][無し]
     
    【目的】循環器疾患危険因子の正しい知識を持つ者ほど、循環器疾患発症に予防的な健康行動をとることが報告されている。そこで本研究では本邦国民における循環器疾患危険因子の認知度を明らかにするとともに、危険因子保有と認知度との関連を検討した。【方法】平成22年国民健康・栄養調査に参加した全国300地区からの20歳以上の男女2,891名に対し、「心筋梗塞または脳卒中の原因として正しいと思うもの」を選択する質問調査を実施した。正答は高血圧、糖尿病、高コレステロール血症、喫煙、不整脈、HDLコレステロール低値である。ロジスティック回帰分析で、各危険因子の保有者をそれぞれの非保有者と比較し、危険因子を認知している年齢調整オッズ比を算出した。【結果】循環器疾患危険因子の認知度はそれぞれ、85.8%(高血圧)、72.6%(高コレステロール血症)、58.5%(喫煙)、49.8%(不整脈)、45.1%(糖尿病)、38.5%(HDLコレステロール低値)であった。男性では、各危険因子の非保有者を基準とした時、高血圧者の高血圧認知度、高コレステロール血症を有する者の高コレステロール血症認知度、過去の喫煙習慣を有する者で喫煙に関する認知度、糖尿病者の糖尿病認知度が有意に高かった(オッズ比1.33〜2.73)。女性では、高コレステロール血症を有する者の高コレステロール血症認知度、過去の喫煙習慣を有する者で喫煙に関する認知度、糖尿病者の糖尿病認知度が有意に高かった(オッズ比1.54〜1.80)。【結論】循環器疾患危険因子の認知度は、高血圧で8割を超える一方、不整脈、糖尿病、HDLコレステロール低値では5割に満たなかった。また、危険因子保有者は保有する危険因子が循環器疾患危険因子であることを認知している傾向が観察されたが、その他の危険因子の認知度は非保有者と同程度、または低い傾向であった。国民に対する循環器疾患危険因子の周知が必要である。(著者抄録)
  • Yukako Tatsumi, Aya Higashiyama, Yoshimi Kubota, Daisuke Sugiyama, Yoko Nishida, Takumi Hirata, Aya Kadota, Kunihiro Nishimura, Hironori Imano, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    JOURNAL OF EPIDEMIOLOGY 26 11 572 - 578 2016年11月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Although underweight young women are targets for interventions to prevent low bone mineral density (BMD), the relationship between change in body mass index (BMI) from youth to older age and BMD has not been widely investigated in community dwellers. Methods: In 749 healthy Japanese women aged 40-74 years, BMD was measured by quantitative ultrasound and anthropometric measurements, and BMI was calculated from body weight and height. The BMI of participants at age 20 years was estimated by self-reported body weight and their present height. They were classified into four groups according to the presence of underweight (BMI <18.5 kg/m(2)) at 20 and/or at present. Logistic regression models were used to estimate multivariate-adjusted odds ratios (ORs) of the presence of underweight at 20 and/or at present for osteopenia (BMD T score <-1 standard deviations) compared with participants with BMI >= 18.5 kg/m(2) both at 20 and at present. Results: The participants who were underweight both at 20 and at present had a higher OR for osteopenia compared with those with BMI >= 18.5 kg/m(2) at 20 and at present (OR 3.94; 95% confidence interval [CI], 1.97-7.89). Those underweight only at present also had significantly increased OR of developing osteopenia (OR 2.95; 95% CI, 1.67-5.24). The OR of those underweight only at 20 was 0.87 (95% CI, 0.51-1.48). Conclusions: Current underweight was associated with increased risk for osteopenia among Japanese women, especially in those who were underweight both at 20 and at present. To prevent low BMD in the future, maintaining appropriate body weight might be effective for young underweight women.
  • Takahiro Ito, Hisatomi Arima, Akira Fujiyoshi, Katsuyuki Miura, Naoyuki Takashima, Takayoshi Ohkubo, Aya Kadota, Takehito Hayakawa, Yoshikuni Kita, Naoko Miyagawa, Akira Okayama, Tomonori Okamura, Hirotugu Ueshima
    INTERNATIONAL JOURNAL OF CARDIOLOGY 220 262 - 267 2016年10月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Non-high-density lipoprotein (HDL) cholesterol level, generally less affected by fasting status or serum triglyceride levels, may be useful for predicting future cardiovascular events in daily clinical practice. This study aimed to investigate the role of non-HDL cholesterol in the development of fatal coronary events and stroke in the general Japanese population. Methods and results: From the NIPPON DATA 90 prospective cohort study, 8383 participants were followed up for 20 years since 1990. After exclusion of 666 cases without lipid or covariates data, 561 cases who were 75 years old or older, 274 cases with history of cardiovascular disease, and 181 cases with lipid-lowering treatment, 6701 participants were included in this analysis. Non-HDL cholesterol was defined as total cholesterol minus HDL cholesterol. Outcomes were death from coronary heart disease and stroke. During the period, 69 participants died from coronary heart disease and 112 from stroke. Compared with participants with non-HDL cholesterol level b3.9 mmol/L, age- and sex-adjusted hazard ratios for mortality by coronary heart disease in those with non-HDL cholesterol levels of 3.9-4.3 mmol/L, 4.4-4.8 mmol/L and >= 4.9 mmol/L were 1.27 (95% confidence interval [CI] 0.65-2.49), 1.81 (95% CI 0.92-3.55) and 2.40 (95% CI 1.30-4.43), respectively (P trend = 0.010). This association remained significant even after adjusting for other cardiovascular risk factors (P trend = 0.010). There was no clear association between non-HDL cholesterol levels and mortality by stroke (P trend= 0.052). Conclusions: Among the general Japanese population, non-HDL cholesterol levels were clearly associated with future mortality by coronary heart disease, but not by stroke. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Robert D. Abbott, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Yasuyuki Nakamura, Tomonori Okamura, Hirotsugu Ueshima
    JOURNAL OF CLINICAL LIPIDOLOGY 10 5 1195 - 1202 2016年10月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C). OBJECTIVES: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDLC, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis. METHODS: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; >0 Agatston score) were examined. RESULTS: LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made. CONCLUSIONS: In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P. (C) 2016 National Lipid Association. All rights reserved.
  • Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Sayuki Torii, Sentaro Suzuki, Naoko Miyagawa, Atsushi Sato, Masahiro Yamazoe, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Yamamoto, Kiyoshi Murata, Robert D. Abbott, Akira Sekikawa, Minoru Horie, Hirotsugu Ueshima
    JOURNAL OF THE AMERICAN HEART ASSOCIATION 5 9 2016年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background-Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia. Methods and Results-In a population-based sample of 1019 Japanese men aged 40 to 79 years, without CVD, we examined cross-sectional associations of smoking status, cumulative pack-years, daily consumption, and time since cessation, with subclinical atherosclerosis at 4 anatomically distinct vascular beds, including coronary artery calcification, carotid intima-media thickness (CIMT) and plaque, aortic artery calcification (AoAC), and ankle-brachial index. Current, former, and never smoking were present in 32.3%, 50.0%, and 17.7%, respectively. Compared to never smokers, current smokers had significantly higher risks of subclinical atherosclerosis in all 4 circulations (eg, odds ratios for coronary artery calcification >0, 1.79 [95% CIs, 1.16-2.79]; CIMT >1.0 mm, 1.88 [1.02-3.47]; AoAC >0, 4.29 [2.30-7.97]; and ankle-brachial index <1.1, 1.78 [1.16-2.74]) and former smokers did in carotid and aortic circulations (CIMT >1.0 mm, 1.94 [1.13-3.34]; and AoAC >0, 2.55 [1.45-4.49]). Dose-response relationships of pack-years and daily consumption, particularly with CIMT, carotid plaque, AoAC, and ankle-brachial index, were observed among both current and former smokers, and even a small amount of pack-years or daily consumption among current smokers was associated with coronary artery calcification and AoAC, whereas time since cessation among former smokers was linearly associated with lower burdens of all atherosclerotic indices. Conclusions-Cigarette smoking was strongly associated with subclinical atherosclerosis in multiple vascular beds in Japanese men, and these associations attenuated with time since cessation.
  • Nishikawa T, Okamura T, Shima A, Kawatsu Y, Sugiyama D, Kadota A, Morimoto A, Tatsumi Y, Godai K, Miyamatsu N
    Diabetology international 7 3 252 - 258 2016年09月 [有り][無し]
     
    Background: The utility of casual serum triglyceride (TG) as a predictor of type 2 diabetes mellitus (DM) is unclear, especially during the most productive years. Methods: Participants were 3271 workers (913 men and 2358 women, age 20-57) without DM at baseline. They underwent consecutive annual medical check-ups for 8 years. The association between newly diagnosed DM and casual serum TG level was determined by classifying the participants into 4 groups according to casual serum TG level at baseline: below 50 mg/dL (group A), 50-100 mg/dL (group B), 100-150 mg/dL (group C), and ≥150 mg/dL (group D). The effects of casual serum TG level in combination with sex, obesity, or serum glucose level on newly diagnosed DM were also evaluated. Results: A total of 222 newly diagnosed type 2 DM cases with a mean age of 50 years old were observed during the follow-up period, i.e., 10/406 in group A, 66/1534 in group B, 58/712 in group C, and 88/619 in group D. Compared with group A, the odds ratio (ORs) for newly diagnosed DM (after adjusting for DM-associated factors) was found to increase with casual serum TG level: 1.38 (group B), 1.79 (group C), and 2.36 (group D). Moreover, the OR for newly diagnosed DM was higher in participants with high casual serum TG levels who were also male (OR 2.46), obese (OR 4.18), or had a high serum glucose level (OR 6.96) than in the reference group. Conclusions: Serum TG level ≥150 mg/dL when fasting or nonfasting is a significant predictor of type 2 diabetes in middle-aged Japanese workers.
  • Mana Kogure, Naho Tsuchiya, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naomi Miyamatsu, Hideo Tanaka, Ichiro Wakabayashi, Aya Higashiyama, Nagako Okuda, Naoyuki Takashima, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
    HYPERTENSION RESEARCH 39 9 670 - 679 2016年09月 [有り][無し]
     研究論文(学術雑誌) 
    The influence of alcohol intake on hypertension may vary depending on the flushing response, but this relationship has not been confirmed. The relationship between alcohol intake and hypertension was examined according to the flushing response in a representative sample of the Japanese population. Participants in the National Health and Nutrition Survey in 2010 were asked to participate in the baseline survey of NIPPON DATA2010. Here, we investigated the relationship between alcohol intake and hypertension according to the flushing response. Statistical analyses were performed in a cross-sectional manner using multiple logistic regression models after adjusting for age, body mass index, smoking status, present illness of diabetes mellitus and present illness of dyslipidemia. Of the 1139 men and 1263 women, 659 and 463, respectively, had hypertension. Among the men, alcohol intake was positively associated with hypertension, regardless of the flushing response (P for linear trend both <0.05). This positive relationship was observed for both users and non-users of antihypertensive drugs. No interaction with the flushing response was observed (P for interaction=0.360). In women, although the direction differed between flushers and non-flushers, the association between alcohol intake and hypertension was not significant, regardless of flushing response. In conclusion, In Japanese men, alcohol intake was positively associated with hypertension in a manner that was not influenced by the flushing response.
  • Mitsuaki Sawano, Shun Kohsaka, Tomonori Okamura, Taku Inohara, Daisuke Sugiyama, Makoto Watanabe, Yasuyuki Nakamura, Aya Higashiyama, Aya Kadota, Nagako Okud, Yoshitaka Murakami, Takayoshi Ohkubo, Akira Fujiyoshi, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    ATHEROSCLEROSIS 252 116 - 121 2016年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background and aims: The European Society of Cardiology developed prediction models (SCORE) for lowand high-risk populations in the European countries. However, whether or not these models are valid in different ethnicities is unknown. We aimed to evaluate the performance of the low-risk SCORE model in the general Japanese population. Methods: Healthy middle-aged Japanese participating in the NIPPON DATA80 cohort had been observed. The predicted 10-year cardiovascular death risk was calculated using the low-risk SCORE model for the overall population as well as for each gender individually. The model performance of the low-risk SCORE model was evaluated with the Harrel's c-statistics for discrimination and the Gronnesby and Borgan goodness-of-fit test for calibration. Results: A total of 4842 participants aged 40-64 years old and 47,606 person-years were evaluated in our study. 203 (4.19%) died within the ten-years of follow-up and 44 (0.91%) CV deaths were observed. The low-risk SCORE model in the overall population had reasonable discrimination (c statistics 0.72, 95% CI 0.71-0.73) but poor calibration (R-2, 0.67, Chi-square value 6.15, p = 0.01). Discrimination was reasonable in both men (c statistics 0.71, 95% CI 0.69e0.73) and women (c statistics 0.71, 95% CI 0.70-0.73). However, calibration was poor in men (R-2, 0.22, Chi-square value 0.749, p = 0.38) compared to women (R-2, 0.96, Chi-square value 1.39, p = 0.24). Conclusions: Although the low-risk SCORE model performs reasonably well in women, the SCORE models generally overestimated the risk of cardiovascular death risk in the Japanese general population. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Sayuki Torii, Itsuko Miyazawa, Akira Fujiyoshi, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 36 8 1703 - 1708 2016年08月 [有り][無し]
     研究論文(学術雑誌) 
    Objective The association between insulin resistance (IR) and coronary artery calcification (CAC) has been uncertain after adjustment for metabolic syndrome components. We aimed to evaluate whether IR is associated with CAC prevalence or progression independently of metabolic syndrome components. Approach and Results We conducted a population-based study in a random sample of Japanese men aged 40 to 79 years and determined IR using the homeostasis model assessment of insulin resistance (HOMA-IR). The associations of HOMA-IR and other diabetic parameters per 1-SD increase with CAC prevalence and progression were evaluated using multivariable logistic regression. Of 1006 total participants at baseline (mean age, 6410 years), CAC prevalence was observed in 646 (64.2%), and of 789 participants at follow-up (mean duration, 4.9 +/- 1.3 years), CAC progression was observed in 365 (46.3%). After adjustment for covariates including metabolic syndrome components, higher HOMA-IR was independently associated with CAC prevalence (adjusted odds ratio 1.34, 95% confidence interval 1.10-1.63; P=0.003) and progression (odds ratio 1.32, 95% confidence interval 1.09-1.60; P=0.004). In participants without diabetes mellitus, positive associations were similarly observed (prevalence: odds ratio 1.29, 95% confidence interval 1.04-1.60; P=0.022; and progression: odds ratio 1.25, 95% confidence interval 1.01-1.55; P=0.042), whereas glucose and hemoglobin A1c were not associated with CAC prevalence and progression. Conclusions Higher IR was associated with CAC prevalence and progression independently of metabolic syndrome components in Japanese men and also in those without diabetes mellitus. Among diabetic measures, IR and fasting insulin, but not glucose and hemoglobin A1c, predicted CAC progression in men without diabetes mellitus.
  • T. H. Hisamatsu, K. M. Miura, H. A. Arima, S. K. Kadowaki, S. T. Torii, S. S. Suzuki, N. M. Miyagawa, A. Kadota, A. F. Fujiyoshi, T. O. Ohkubo, H. U. Ueshima
    EUROPEAN HEART JOURNAL 37 9 223 - 223 2016年08月 [有り][無し]
  • 糖尿病患者における肥満合併率の推移と肥満別臨床的特徴-滋賀県医師会糖尿病実態調査より
    宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫, 滋賀県医師会糖尿病実態調査委員会
    日本肥満症治療学会学術集会プログラム・抄録集 34回 115 - 115 日本肥満症治療学会 2016年07月
  • Takehiro Michikawa, Tomonori Okamura, Hiroshi Nitta, Yuji Nishiwaki, Toru Takebayashi, Kayo Ueda, Aya Kadota, Akira Fujiyoshi, Takayoshi Ohkubo, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura
    ENVIRONMENTAL POLLUTION 213 460 - 467 2016年06月 [有り][無し]
     研究論文(学術雑誌) 
    A suggestive mechanism behind the association between particulate matter and cardiovascular disease is inflammatory response. Earlier population-based studies investigating the association between particulate matter and inflammatory biological markers, in particular C-reactive protein (CRP), showed inconsistent results. In addition, evidence from the Asian population, in which CRP levels are typically lower than those observed in Western populations, was sparse. We examined the cross-sectional association between short- and long-term exposure to particulate matter and inflammatory markers, including high-sensitivity CRP (hs-CRP) and white blood cell (WBC) count, in a representative population of Japanese community dwellers (NIPPON DATA2010). We analysed data from 2360 participants (1002 men and 1358 women), aged 20 years or older, who resided in 300 randomly selected districts (222 public health centre areas) throughout Japan. We used background concentrations of suspended particulate matter (SPM, defined as particles with a 100% cut-off level at 10 gm aerodynamic diameter) and co-pollutants within the public health centre area. A logistic regression model was applied to estimate odds ratios (ORs) of elevated hs-CRP (>0.3 mg/dl) or WBC (> 9000/mu l). Since smoking is an important confounding factor, we firstly included this in the models, and additionally conducted the analyses after excluding current smokers. The one-month average concentration of SPM was positively associated with hs-CRP (OR per 10 mu g/m(3) increase in SPM = 1.42, 95% confidence interval = 1.00-2.04), and high exposure to SPM on the day of blood draw was associated with increased WBC count, after excluding current smokers (OR = 1.13, 1.01-1.28). Similar association patterns were observed for ozone. In conclusion, exposure to particulate matter was associated with inflammatory markers in the general Japanese population. Systemic inflammation may play a role in the link between particulate matter and cardiovascular disease. (C) 2016 Elsevier Ltd. All rights reserved.
  • Mitsuaki Sawano, Shun Kohsaka, Tomonori Okamura, Taku Inohara, Daisuke Sugiyama, Yasuyuki Shiraishi, Makoto Watanabe, Yasuyuki Nakamura, Aya Higashiyama, Aya Kadota, Nagako Okuda, Yoshitaka Murakami, Takayoshi Ohkubo, Akira Fujiyoshi, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    PLOS ONE 11 6 e0157563  2016年06月 [有り][無し]
     研究論文(学術雑誌) 
    Aims The long-term prognostic effect of non-specific 12-lead electrocardiogram findings is unknown. We aimed to evaluate the cumulative prognostic impact of axial, structural, and repolarization categorical abnormalities on cardiovascular death, independent from traditional risk scoring systems such as the Framingham risk score and the NIPPON DATA80 risk chart. Methods and Results A total of 16,816 healthy men and women from two prospective, longitudinal cohort studies were evaluated. 3,794 (22.6%) individuals died during a median follow-up of 15 years (range, 2.0-24 years). Hazard ratios for cardiovascular death, all-cause death, coronary death and stroke death were calculated for the cumulative and independent axial, structural, and repolarization categorical abnormalities adjusted for the Framingham risk score and the NIPPON DATA80 risk chart. Individuals with two or more abnormal categories had a higher risk of cardiovascular death after adjustment for Framingham risk score (men: HR 4.27, 95% CI 3.35-5.45; women: HR 4.83, 95% CI 3.76-6.22) and NIPPON DATA80 risk chart (men: HR 2.39, 95% CI 1.87-3.07; women: HR 2.04, 95% CI 1.58-2.64). Conclusion Cumulative findings of axial, structural, and repolarization abnormalities are significant predictors of long-term cardiovascular death in asymptomatic, healthy individuals independent of traditional risk stratification systems.
  • Yuichiro Nishida, Megumi Hara, Tatsuhiko Sakamoto, Koichi Shinchi, Sayo Kawai, Mariko Naito, Nobuyuki Hamajima, Aya Kadota, Sadao Suzuki, Rie Ibusuki, Akie Hirata, Miwa Yamaguchi, Nagato Kuriyama, Isao Oze, Haruo Mikami, Michiaki Kubo, Hideo Tanaka
    Preventive medicine reports 3 288 - 95 2016年06月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVE: Inflammation is closely involved in the development of type 2 diabetes, and cigarette smoking acts as potent inducer of inflammation. We therefore investigated interactions between inflammation-related gene polymorphisms and cigarette smoking on glycated hemoglobin (HbA1c) in the Japanese general population. METHOD: We conducted a cross-sectional study using data collected from 2619 Japanese (1274 males and 1345 females) 40-69 years of age who participated in baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (2005-2008). Eight polymorphisms in seven genes (interleukin [IL]-1β, IL-2, IL-4, IL-8, IL-10, IL-13 and tumor necrosis factor-α) were determined using the Invader assay. The interactions of smoking and gene polymorphisms on HbA1c levels were analyzed using multiple linear and logistic regression models and analysis of covariance with adjustment for potential confounders. RESULTS: Among the eight polymorphisms, only one significant interaction was detected for IL-1β T-31C (P < 0.0001). Among the subjects carrying TT genotype, current heavy smokers (≥ 20 cigarettes/day) had higher HbA1c (5.83 [95% confidence interval 5.67-5.99] %) versus all other smoking status groups (never 5.49 [5.41-5.56] %, former 5.54 [5.43-5.65] %, current moderate [< 20 cigarettes/day] 5.50 [5.30-5.69] %), whereas such differences were not observed in the subjects with C allele. The logistic regression analyses regarding high-normal HbA1c levels showed a similar pattern of results. CONCLUSION: Smoking status did not interact with any other inflammation-related polymorphisms except for IL-1β T-31C. Heavy smokers harboring the TT genotype of IL-1β T-31C polymorphism show a greater adverse effect of smoking on HbA1c levels among Japanese middle-aged subjects.
  • Takumi Hirata, Aya Higashiyama, Yoshimi Kubota, Daisuke Sugiyama, Kazuyo Kuwabara, Yukako Tatsumi, Aya Hirata, Yoko Nishida, Aya Kadota, Hironori Imano, Tomofumi Nishikawa, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 51 3 173 - 183 2016年06月 [有り][無し]
     研究論文(学術雑誌) 
    Individuals with an inactive acetaldehyde dehydrogenase 2 have an. elevated level of serum acetaldehyde after drinking alcohol, and this may cause an alcohol flushing response with symptoms such as facial flushing, tachycardia, headache, and nausea. Recent studies have suggested that the flushing response influences the association between alcohol consumption and various health-related outcomes. In the present study, we investigated the impact of the flushing response on the relationship between alcohol consumption and serum y -GTP levels in Japanese drinkers. We conducted a cross-sectional study of 521 Japanese drinkers (260 men and 261 'vomen) to examine the impact of the alcohol flushing response on the relationship between alcohol consumption and serum y -GTP levels. The subjects were divided into three groups according to the amount .of daily alcohol consumption. (low, <20 g; moderate, 20-39 g;. and high, >40 g). Multiple adjustments were performed with linear regression models to examine the association between daily alcohol consumption and serum y-GTP levels, adjusting for potential con- founders including the flushing response. We found that the proportion of flushers was significantly lower in the high alcohol consumption group than in the low consumption group. The results of a multivariable analysis showed that,serum y -GTP levels were significantly higher in the moderate and high consumption groups than in the low consumption group after. adjusting for all potential confounders other than the flushing response. In addition, the association between serum y -GTP levels and alcohol consumption was unchanged after adjusting for the presence of the flushing response. In conclusion, serum y -GTP levels increased with increasing alcohol-consumption regardless of the flushing response. Screening for heavy drinkers using serum y-GTP levels was very important to prevent alcohol-related diseases or health problems in health examination.
  • 眼底検査、尿中アルブミン測定実施の現況と今後の課題 滋賀県医師会糖尿病実態調査より
    宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫
    糖尿病 59 Suppl.1 S - 472 (一社)日本糖尿病学会 2016年04月
  • 日本人男性における心臓周囲脂肪量の縦断的変化の予測因子とは 滋賀動脈硬化疫学研究(SESSA)(Which Factors Predict Longitudinal Change of Pericardial Fat Volume in Japanese Men? The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA))
    Miyazawa Itsuko, Ohkubo Takayoshi, Kadowaki Sayaka, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Arima Hisatomi, Miura Katsuyuki, Maegawa Hiroshi, Ueshima Hirotsugu
    Circulation Journal 80 Suppl.I 823 - 823 2016年03月
  • Hirotsugu Ueshima, Takashi Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Akira Sekikawa, Aya Kadota, Sayaka Kadowaki, Yasuyuki Nakamura, Naoko Miyagawa, Tomonori Okamura, Yoshikuni Kita, Naoyuki Takashima, Atsunori Kashiwagi, Hiroshi Maegawa, Minoru Horie, Takashi Yamamoto, Takeshi Kimura, Toru Kita
    ATHEROSCLEROSIS 246 141 - 147 2016年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme predominantly bound to low-density lipoprotein (LDL). Lp-PLA2 is recognized as playing a key role in inflammatory processes and the development of atherosclerosis. This study aimed to investigate whether Lp-PLA2 is related to subclinical atherosclerosis, independently from traditional risk factors, in a general Japanese population by analyses of both the observational study and Mendelian randomization using V279F polymorphism. Methods and results: We cross-sectionally examined community-based sample of 929 Japanese men aged 40-79 years, without statin treatment, who were randomly selected from the resident registration. Multiple regression analyses of Lp-PLA2 activity and concentration were undertaken separately for men aged 40-49 years and 50-79 years, to clarify interactions of age and Lp-PLA2. Lp-PLA2 activity for men aged 50-79 years was significantly and positively related to intima-media thickness (IMT) (P = 0.013) and plaque index (P = 0.008) independent of traditional risk factors including small LDL particles, but not to coronary artery calcification (CAC) score. Associations with Lp-PLA2 concentration were qualitatively similar to those of activity. Corresponding relationships were not observed in men aged 40e49 years. Mendelian randomization analyses based on V279F genotype did not show any significant associations with subclinical atherosclerosis, although the homozygote and heterozygote of V279F showed low LpPLA2 activity and concentration. Conclusions: Lp-PLA2 activity in Japanese men aged 50-79 years was associated significantly and positively with IMT and plaque in the carotid artery but Mendelian randomization did not support that LpPLA2 is a causative factor for subclinical atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
  • Tomonori Okamura, Katsuyuki Miura, Tatsuya Sawamura, Aya Kadota, Takashi Hisamatsu, Akira Fujiyoshi, Naomi Miyamatsu, Naoyuki Takashima, Naoko Miyagawa, Takashi Kadowaki, Takayoshi Ohkubo, Yoshitaka Murakami, Yasuyuki Nakamura, Hirotsugu Ueshima
    JOURNAL OF CLINICAL LIPIDOLOGY 10 1 172 - 180 2016年02月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than usual lipid parameters; however, the relationship between LAB and carotid intima-media thickness (IMT) was not clear even in Asian populations. METHODS: A total of 992 community-dwelling Japanese men, aged 40 to 79 years, were enrolled in the present study. Serum LAB levels were measured by enzyme-linked immunosorbent assays (ELISAs) with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. RESULTS: Serum LAB levels (median [interquartile range], mu g cs/L) were 5341 mu g cs/L (4093-7125). The mean average IMT of the common carotid artery was highest in the fourth LAB quartile (842 mu m) compared with the first quartile (797 mu m) after adjustment for age, high-density lipoprotein cholesterol, triglyceride, body mass index, hypertension, diabetes, high sensitivity C-reactive protein, smoking, and alcohol drinking. However, this statistically significant difference was lost after further adjustment for total cholesterol (TC). After stratification using the combination of median LAB and hypercholesterolemia (serum TC >= 6.21 mmol/L and/or lipid-lowering medication), the adjusted mean average IMT (standard error) in the high LAB/hypercholesterolemia group was 886 mu m (12.7), 856 mu m (16.7) in the low LAB/hypercholesterolemia group, and 833 mu m (8.4) in the low LAB/normal cholesterol group (P = .004). After further adjustment for TC, mean average IMT in the high LAB group was significantly higher than that measured in the low LAB group in hypercholesterolemic participants not taking lipid-lowering medication. CONCLUSION: Serum LAB was associated with an increased carotid IMT in Japanese men, especially those with hypercholesterolemia. (C) 2016 National Lipid Association. All rights reserved.
  • Masato Nagai, Takayoshi Ohkubo, Katsuyuki Miura, Akira Fujiyoshi, Nagako Okuda, Takehito Hayakawa, Katsushi Yoshita, Yusuke Arai, Hideaki Nakagawa, Koshi Nakamura, Naoko Miyagawa, Naoyuki Takashima, Aya Kadota, Yoshitaka Murakami, Yasuyuki Nakamura, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 23 3 339 - 354 2016年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: In animals, dietary energy restriction is reported to increase longevity, whereas in humans, all cohort studies from Western countries have not shown an association between the low energy intake and longevity. We examined the association between total energy intake and longevity in Japan where dietary pattern is different from that in the West. Methods: A total of 7,704 Japanese aged 30-69 years were followed from 1980 to 2009. Participants were divided into the quintiles of total energy (kcal/day) based on data collected from the National Nutrition Survey. Hazard ratios and 95% confidence intervals (CIs) were derived through the use of Cox proportional hazards models to compare the risk of death across and between the quintiles. Results: There was a significant association between increased energy intake and all-cause mortality risk in only men (P for linear trend 0.008). In cause-specific analysis, compared with the lowest quintile, there was rise in coronary heart disease (CHD) mortality among men (HR; 2.63, 95% CI; 0.95-7.28, P for linear trend 0.016) and women (HR; 2.91, 95% CI; 1.02-8.29, P for linear trend 0.032) and cancer mortality among men (HR; 1.50, 95% CI; 0.999-2.24, P for linear trend 0.038) in the top quintile. Conclusion: We observed significant associations of high energy intake with all-cause and cancer mortality among men and with CHD mortality among men and women. Further studies are needed to confirm the benefits of caloric restriction.
  • Aya Hirata, The NIPPON DATA90 Research Group, Tomonori Okamura, Daisuke Sugiyama, Kazuyo Kuwabara, Aya Kadota, Akira Fujiyoshi, Katsuyuki Miura, Nagako Okuda, Takayoshi Ohkubo, Akira Okayama, Hirotsugu Ueshima, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yoshikazu Nakamura, Nobuo Nishi, Fumiyoshi Kasagi, Yoshitaka Murakami, Toru Izumi, Yasuhiro Matsumura, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshikuni Kita, Naomi Miyamatsu, Katsushi Yoshita, Yoshihiro Miyamoto, Kazunori Kodama, Yutaka Kiyohara
    Journal of Atherosclerosis and Thrombosis 23 7 800 - 809 2016年 [有り][無し]
     研究論文(学術雑誌) 
    Aims: There is no community-based cohort study to examine the effect of very high level of highdensity lipoprotein cholesterol (HDL-C) on coronary heart disease (CHD) and other cause-specific mortality. Therefore, we investigated the relationship between HDL-C including very high level and cause-specific mortality in a 20-year cohort study of the representative sample of Japanese. Methods: We followed 7,019 individuals from the Japanese general population (2,946 men and 4,073 women). We defined HDL-C levels as follow: low (HDL-C < 1.04 mmol/L), reference (1.04-1.55 mmol/L), high (1.56- 2.06 mmol/L), very high (≥2.07 mmol/L). The multivariate adjusted hazard ratio (HR) for all-cause or cause-specific mortality was calculated using a Cox proportional hazards model adjusted for other traditional risk factors. Results: During follow-up, we observed 1,598 deaths. No significant association was observed between HDL-C and all-cause mortality. Serum HDL-C also showed no association with stroke. In contrast, the risk for CHD among high HDL-C was lower than reference, HRs were 0.51 [95% confidence interval (CI): 0.21-1.23] in men, 0.33 (95% CI: 0.11-0.95) in women, and 0.41 (95% CI: 0.21 -0.81) when men and women were combined. However, very high HDL-C did not show significant association with CHD and other cause-specific mortality. Conclusions: HDL-C was not associated with all-cause and stroke mortality. In contrast, high serum HDL-C levels, at least up to 2.06 mmol/L, were protective against CHD, although further high levels were not. However, sample size of cause-specific death in very high HDL-C group was not enough even in this 20-year follow-up of 7,019 Japanese larger cohort studies should be warranted.
  • Nagai Masato, Ohkubo Takayoshi, Murakami Yoshitaka, Takashima Naoyuki, Kadota Aya, Miyagawa Naoko, Saito Yoshino, Nishi Nobuo, Okuda Nagako, Kiyohara Yutaka, Nakagawa Hideaki, Nakamura Yoshikazu, Fujiyoshi Akira, Abbott Robert D, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu, Miura Katsuyuki
    Hypertension Research 38 11 798  2015年11月 [無し][無し]
  • Masato Nagai, Takayoshi Ohkubo, Yoshitaka Murakami, Naoyuki Takashima, Aya Kadota, Naoko Miyagawa, Yoshino Saito, Nobuo Nishi, Nagako Okuda, Yutaka Kiyohara, Hideaki Nakagawa, Yoshikazu Nakamura, Akira Fujiyoshi, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Katsuyuki Miura
    HYPERTENSION RESEARCH 38 11 790 - 795 2015年11月 [有り][無し]
     研究論文(学術雑誌) 
    The prevalence of overweight (body mass index (BMI)= 25.0-29.9 kgm(-2)) and obesity (>= 30.0 kgm(-2)) has been increasing over the last several decades in Japan. We examined trends of the impact of overweight and obesity on hypertension (systolic/diastolic blood pressure. 140/90mmHg or antihypertensive drugs use) using four national surveys in Japan, from which the participants were randomly sampled from the entire population. Study participants aged 30-79 years were selected for each survey (10 370 in 1980, 8005 in 1990, 5327 in 2000 and 2547 in 2010). The results showed that the impact of overweight and obesity on hypertension had increased significantly (P=0.040 and 0.006 in men and women, respectively). From 1980 to 2010, the multivariable-adjusted odds ratios for hypertension, comparing overweight and obesity with normal weight (BMI = 18.5-24.9 kgm(-2)), went from 1.94 (95% confidence intervals: 1.64, 2.28) to 2.82 (2.07, 3.83) in men, and from 2.37 (2.05, 2.73) to 3.48 (2.57, 4.72) in women. Most of the association was observed in overweight participants, as only 3% of the Japanese were obese. In addition to the relationship between excessive BMI and other adverse health conditions, the rise in the association with hypertension increases the urgency in addressing weight control. We need to address the overweight and obesity epidemic.
  • Masato Nagai, Takayoshi Ohkubo, Yoshitaka Murakami, Naoyuki Takashima, Aya Kadota, Naoko Miyagawa, Yoshino Saito, Nobuo Nishi, Nagako Okuda, Yutaka Kiyohara, Hideaki Nakagawa, Yoshikazu Nakamura, Akira Fujiyoshi, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Katsuyuki Miura
    HYPERTENSION RESEARCH 38 11 790 - 795 2015年11月 [有り][無し]
     研究論文(学術雑誌) 
    The prevalence of overweight (body mass index (BMI)= 25.0-29.9 kgm(-2)) and obesity (>= 30.0 kgm(-2)) has been increasing over the last several decades in Japan. We examined trends of the impact of overweight and obesity on hypertension (systolic/diastolic blood pressure. 140/90mmHg or antihypertensive drugs use) using four national surveys in Japan, from which the participants were randomly sampled from the entire population. Study participants aged 30-79 years were selected for each survey (10 370 in 1980, 8005 in 1990, 5327 in 2000 and 2547 in 2010). The results showed that the impact of overweight and obesity on hypertension had increased significantly (P=0.040 and 0.006 in men and women, respectively). From 1980 to 2010, the multivariable-adjusted odds ratios for hypertension, comparing overweight and obesity with normal weight (BMI = 18.5-24.9 kgm(-2)), went from 1.94 (95% confidence intervals: 1.64, 2.28) to 2.82 (2.07, 3.83) in men, and from 2.37 (2.05, 2.73) to 3.48 (2.57, 4.72) in women. Most of the association was observed in overweight participants, as only 3% of the Japanese were obese. In addition to the relationship between excessive BMI and other adverse health conditions, the rise in the association with hypertension increases the urgency in addressing weight control. We need to address the overweight and obesity epidemic.
  • 宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫, 滋賀県医師会糖尿病実態調査委員会
    肥満研究 21 Suppl. 148 - 148 (一社)日本肥満学会 2015年09月
  • 安川 優, 門田 文
    大阪教育大学紀要. 第5部門, 教科教育 = Memoirs of Osaka Kyoiku University 64 1 99 - 115 大阪教育大学 2015年09月 [無し][無し]
     
    小中高等学校の教員(人権担当又は担任経験のある教員,養護教諭)278名に「性の違和感や迷いを感じる児童生徒」に関する学校の現状や困難点,ニーズ等について郵送アンケート調査を行った。結果,人権・担任教員の83.6%,養護教諭の92.4%が今までに「性の違和感や迷いを感じる者」に関して学び,知識・情報を得る機会があった。また,全体の約半数がこれまでに該当児童生徒の存在に気付き,対応した経験があった。しかし全体の半数が該当児童生徒への対応等に不安や困難を感じており,「未経験・経験不足」「知識・情報不足」「学校の体制がまだ整っていない」等が理由として挙げられた。実際の対応例を含めた知識・情報の教職員への普及が必要である。We performed a mailed questionnaire survey about the experience, difficulties, and the needs for the students who feel sense of incongruity or ambivalence of sexual identity to 278 teachers (teachers in charge of human rights or those with class, and school nursing teacher) of high schools, junior high schools, and elementary schools. As a result, 83.6% of teachers in charge of human rights or those with class and 92.4% of school nursing teacher had opportunities to learn about the people who feel sense of incongruity or ambivalence of sexual identity ever. In addition, about half of overall teachers noticed existence of students who feel sense of incongruity or ambivalence of sexual identity at schools, and they experienced to support them. However, half of overall teachers feel uneasiness and difficulties to support those students. The reason was "Lack of experience and no experience", "Lack of knowledge and information", and "The supporting system of the school is not fully ready yet". It is necessary to provide informations abous konwledges and the examples of school support which were really helpful for the school staffs.
  • Kubota Yoshimi, Higashiyama A, Imano H, Sugiyama D, Kawamura K, Kadota A, Nishimura K, Miyamatsu N, Miyamoto Y, Okamura T
    Journal of Nutrition, Health and Aging 19 7 719 - 728 2015年08月 [有り][無し]
     研究論文(学術雑誌) 
    <p>Background/Objectives: Serum polyunsaturated fatty acid (PUFA) composition reflects dietary intake and is related to risks for cardiovascular diseases. We hypothesized that serum n-3 PUFA composition, especially including long-chain n-3 PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with inflammatory status, which is related to increased risk for cardiovascular diseases. Subjects/Methods: We investigated the relationship between serum PUFA composition and high-sensitivity C-reactive protein (hs-CRP) levels in a cross-sectional study among 1,102 healthy men and women aged 40–74 years who reside in Kobe City. Multiple linear regression models that predict hs-CRP level were prepared to confirm the contribution of serum total n-3 PUFA, long-chain n-3 PUFA, EPA and DHA compositions after adjusting for other PUFAs and atherosclerotic risk factors. Results: The serum n-3 PUFA, particularly long-chain n-3 PUFA, compositions were inversely associated with the hs-CRP levels. The standardized regression coefficient was −0.089 (p < 0.01) for total n-3 PUFA, −0.091 (p < 0.01) for long-chain n-3 PUFA, −0.071 (p = 0.03) for EPA, and −0.06
  • Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J. M. Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa
    INTERNATIONAL JOURNAL OF CARDIOLOGY 189 67 - 72 2015年06月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess cardiovascular disease (CVD) risk in eastern Asia. We examined whether baPWV is associated with coronary atherosclerosis in an international study of healthy middle-aged men. Methods: A population-based sample of 1131men aged 40-49 years was recruited - 257 Whites and 75 Blacks in Pittsburgh, US, 228 Japanese-Americans in Honolulu, US, 292 Japanese in Otsu, Japan, and 279 Koreans in Ansan, Korea. baPWV was measured with an automated waveform analyzer (VP2000, Omron) and atherosclerosis was examined as coronary artery calcification (CAC) by computed-tomography (GE-Imatron EBT scanner). Association of the presence of CAC (defined as >= 10 Agatston unit) was examined with continuous measure as well as with increasing quartiles of baPWV. Results: As compared to the lowest quartile of baPWV, the multivariable-adjusted odds ratio (95% Confidence Interval [CI]) for the presence of CAC in the combined sample was 1.70 (0.98, 2.94) for 2nd quartile, 1.88 (1.08, 3.28) for 3rd quartile, and 2.16 (1.19, 3.94) for 4th quartile (p-trend = 0.01). The odds for CAC increased by 19% per 100 cm/s increase (p < 0.01), or by 36% per standard-deviation increase (p < 0.01) in baPWV. Similar effect-sizes were observed in individual races, and were significant among Whites, Blacks and Koreans. Conclusion: baPWV is cross-sectionally associated with CAC among healthy middle-aged men. The association was significant in Whites and Blacks in the US, and among Koreans. Longitudinal studies are needed to determine its CVD predictive ability. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
  • Maryam Zaid, SESSA Research group, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Emiko Ogawa, Itsuko Miyazawa, Kiyoshi Murata, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Emma Barinas-Mitchell, Daniel Edmundowicz, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Takashi Kadowaki, Sayaka Kadowaki, Yoshitaka Murakami, Seiko Ohno
    Atherosclerosis 239 2 444 - 450 2015年04月 [有り][無し]
     研究論文(学術雑誌) 
    The association of high-density lipoprotein particle (HDL-P) with atherosclerosis may be stronger than that of HDL-cholesterol (HDL-C) and independent of conventional cardiovascular risk factors. Whether associations persist in populations at low risk of coronary heart disease (CHD) remains unclear. This study examines the associations of HDL-P and HDL-C with carotid intima-media thickness (cIMT) and plaque counts among Japanese men, who characteristically have higher HDL-C levels and a lower CHD burden than those in men of Western populations. Methods: We cross-sectionally examined a community-based sample of 870 Japanese men aged 40-79 years, free of known clinical cardiovascular disease (CVD) and not on lipid-lowering medication. Participants were randomly selected among Japanese living in Kusatsu City in Shiga, Japan. Results: Both HDL-P and HDL-C were inversely and independently associated with cIMT in models adjusted for conventional CHD risk factors, including low-density lipoprotein cholesterol (LDL-C) and diabetes. HDL-P maintained an association with cIMT after further adjustment for HDL-C (P< 0.01), whereas the association of HDL-C with cIMT was noticeably absent after inclusion of HDL-P in the model. In plaque counts of the carotid arteries, HDL-P was significantly associated with a reduction in plaque count, whereas HDL-C was not. Conclusion: HDL-P, in comparison to HDL-C, is more strongly associated with measures of carotid atherosclerosis in a cross-sectional study of Japanese men. Findings demonstrate that, HDL-P is a strong correlate of subclinical atherosclerosis even in a population at low risk for CHD.
  • 日本人男性におけるhigh-density lipoprotein粒子濃度と頸動脈の無症候性アテローム性動脈硬化症との関連性(The Association of High-density Lipoprotein Particle Concentration with Subclinical Atherosclerosis of the Carotid Arteries in Japanese Men)
    Zaid Maryam, Fujiyoshi Akira, Miura Katsuyuki, Abbott Robert D., Okamura Tomonori, Takashima Naoyuki, Torii Sayuki, Saito Yoshino, Hisamatsu Takashi, Miyagawa Naoko, Ohkubo Takayoshi, Kadota Aya, Sekikawa Akira, Maegawa Hiroshi, Nakamura Yasuyuki, Mitsunami Kenichi, Ueshima Hirotsugu
    Circulation Journal 79 Suppl.I 634 - 634 2015年03月
  • 一般日本人集団における主要および軽微なECG異常の無症候性アテローム硬化との関連性 SESSA(Association of Major and Minor ECG Abnormalities with Subclinical Atherosclerosis in a General Japanese Population: SESSA)
    Hisamatsu Takashi, Miura Katsuyuki, Fujiyoshi Akira, Kadowaki Sayaka, Zaid Maryam, Torii Sayuki, Kadota Aya, Nakamura Yasuyuki, Horie Minoru, Ueshima Hirotsugu
    Circulation Journal 79 Suppl.I 2059 - 2059 2015年03月
  • Kosuke Matsuzono, Chiaki Yokota, Hidehiro Takekawa, Tomonori Okamura, Naomi Miyamatsu, Hirofumi Nakayama, Kunihiro Nishimura, Satoshi Ohyama, Akiko Ishigami, Kosuke Okumura, Kazunori Toyoda, Yoshihiro Miyamoto, Kazuo Minematsu, Daisuke Sugiyama, Masanori Nagao, Akiko Morimoto, Aya Kadota, Nobue Takizawa, Kayo Ieiri, Teruki Watanabe
    Stroke 46 2 572 - 574 2015年02月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND AND PURPOSE - : Educating the youth about stroke is a promising approach for spreading stroke knowledge. The aim of this study was to verify communication of stroke knowledge to parents by educating junior high school students about stroke. METHODS - : We enrolled 1127 junior high school students (age, 13-15 years) and their parents in the Tochigi prefecture, Japan. All students received a stroke lesson, watched an animated cartoon, and read the related Manga comic as educational aids. The students took back home the Manga and discussed what they learned with their parents. Questionnaires on stroke knowledge were given to all at baseline and immediately after the lesson. RESULTS - : A total of 1125 students and 915 parents answered the questionnaires. In the students, the frequency of correct answers increased significantly for all questions on stroke symptoms except for headache, and for all questions on risk factors after the lesson. In the parents, the correct answer rates increased for stroke symptoms except for headache and numbness in one side of the body, and for all questions on risk factors except for hypertension. Ninety-one percent of students and 92.7% of parents correctly understood the Face, Arm, Speech, and Time (FAST) mnemonic after the lesson. CONCLUSIONS - : Improvement of stroke knowledge immediately after the stroke lesson was observed in parents as well as their children, which indicated that our teaching materials using the Manga was effective in delivering the stroke knowledge to parents through their children.
  • Ahuja V, Kadowaki T, Evans RW, Kadota A, Okamura T, El Khoudary SR, Fujiyoshi A, Barinas-Mitchell EJ, Hisamatsu T, Vishnu A, Miura K, Maegawa H, El-Saed A, Kashiwagi A, Kuller LH, Ueshima H, Sekikawa A, ERA JUMP, Study Group
    Diabetologia 58 2 265 - 271 2015年02月 [有り][無し]
     研究論文(学術雑誌) 
    At the same level of BMI, white people have less visceral adipose tissue (VAT) and are less susceptible to developing type 2 diabetes than Japanese people. No previous population-based studies have compared insulin resistance and insulin secretion between these two races in a standardised manner that accounts for VAT. We compared HOMA-IR, HOMA of beta cell function (HOMA-beta%) and disposition index (DI) in US white men and Japanese men in Japan. We conducted a population-based, cross-sectional study, comprising 298 white men and 294 Japanese men aged 40-49 years without diabetes. Insulin, glucose, VAT and other measurements were performed at the University of Pittsburgh. We used ANCOVA to compare geometric means of HOMA-IR, HOMA-beta% and DI, adjusting for VAT and other covariates. White men had higher HOMA-IR, HOMA-beta% and DI than Japanese men, and the difference remained significant (p < 0.01) after adjusting for VAT (geometric mean [95% CI]): 3.1 (2.9, 3.2) vs 2.5 (2.4, 2.6), 130.8 (124.6, 137.3) vs 86.7 (82.5, 91.0), and 42.4 (41.0, 44.0) vs 34.8 (33.6, 36.0), respectively. Moreover, HOMA-IR, HOMA-beta% and DI were significantly higher in white men even after further adjustment for BMI, impaired fasting glucose and other risk factors. The higher VAT-adjusted DI in white men than Japanese men may partly explain lower susceptibility of white people than Japanese people to developing type 2 diabetes. The results, however, should be interpreted with caution because the assessment of insulin indices was made using fasting samples and adjustment was not made for baseline glucose tolerance. Further studies using formal methods to evaluate insulin indices are warranted.
  • Takashi Hisamatsu, NIPPON DATA80 Research Group, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Takayoshi Ohkubo, Shin-Ya Nagasawa, Minoru Horie, Akira Okayama, Hirotsugu Ueshima, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Nagako Okuda, Fumiyoshi Kasagi, Toru Izumi, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshitaka Murakami, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Katsushi Yoshita, Aya Kadota, Yoshihiro Miyamoto, Kazunori Kodama, Yutaka Kiyohara
    International Journal of Cardiology 184 1 291 - 293 2015年 [有り][無し]
     研究論文(学術雑誌)
  • Daisuke Sugiyama, Tomonori Okamura, Makoto Watanabe, Aya Higashiyama, Nagako Okuda, Yasuyuki Nakamura, Atsushi Hozawa, Yoshikuni Kita, Aya Kadota, Yoshitaka Murakami, Naomi Miyamatsu, Takayoshi Ohkubo, Takehito Hayakawa, Yoshihiro Miyamoto, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 22 1 95 - 107 2015年 [有り][無し]
     研究論文(学術雑誌) 
    Aims: The population-attributable fraction (PAF) is an indicator of the disease burden. In Western countries, the PAF of hypercholesterolemia in cardiovascular disease (CVD) is the highest among that for traditional risk factors; however, data for Asian populations are limited. Methods: A 24-year cohort study was conducted among 9,209 randomly selected participants who were not taking statins. We estimated the hazard ratio (HR) after adjusting for covariates and PAF associated with the serum total cholesterol (TC) levels in relation to CVD mortality. Results: The TC level was found to be positively associated with an increased risk of CVD, coronary heart disease (CHD) and cardiac death (CHD plus heart failure), with an HR of 1.08 (95% confidence interval [CI]: 1.00-1.16), 1.33 (95% CI: 1.14-1.55) and 1.21 (95% CI: 1.08-1.35) for a 1-SD increment in the serum TC level, respectively. Similar positive associations between the TC level and both CHD and cardiac death were observed after classifying the patients by age and sex. Furthermore, the highest serum TC level (>= 6.72 mmol/L) was positively associated with CVD death, with an HR of 1.76 (95% CI: 1.25-2.47), as well as both CHD death and cardiac death. In contrast, no significant relationships were observed between the serum TC level and stroke. Meanwhile, the PAF for CVD, CHD, and cardiac deaths due to hypercholesterolemia (serum TC level >= 5.69 mmol/L, defined by the Japan Atherosclerosis Society) was 1.7%, 10.6% and 5.6%, respectively. Conclusions: The estimated PAF of CVD death due to hypercholesterolemia is moderately high, but lower than that for other risk factors, such as hypertension.
  • Daisuke Sugiyama, Aya Higashiyama, Ichiro Wakabayashi, Yoshimi Kubota, Yoshiko Adachi, Akiko Hayashibe, Kuniko Kawamura, Kazuyo Kuwabara, Kunihiro Nishimura, Aya Kadota, Yoko Nishida, Takumi Hirata, Hironori Imano, Naomi Miyamatsu, Yoshihiro Miyamoto, Tatsuya Sawamura, Tomonori Okamura
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 22 5 499 - 508 2015年 [有り][無し]
     研究論文(学術雑誌) 
    Aims: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligands containing apolipoprotein B (LAB) and lectin-like oxidized LDL receptor-1 (LOX-1) are known as LOX-1-related modified LDL indicators. These indicators play an important role in the early phase atherosclerosis, but the relationship between these indicators and subclinical atherosclerosis, as represented by the cardio-ankle vascular index (CAVI), has not been assessed. We herein investigated the association of LOX-1-related modified LDL indicators and the CAVI in healthy, Japanese urban community inhabitants who were considered to be at low risk for cardiovascular disease (CVD). Methods: The participants were 515 healthy Japanese (310 men and 205 women) without a history of CVD, cancer or the use of medication for hypertension, diabetes or dyslipidaemia. To estimate the association between LOX-1-related modified LDL indicators (LAB, soluble form of LOX-1 (sLOX-1)) and the CAVI, we performed multivariable linear regression analyses with possible confounders such as the serum LDL cholesterol level. Results: The plasma LAB showed a positive association with the CAVI in men (standardized coefficient: 0.11, p=0.04). This relationship was not observed in women. On the other hand, no clear association was observed between the CAVI and the plasma sLOX-1 level in either sex. Conclusions: The plasma LAB levels may represent a useful marker for detecting potential atherosclerosis in healthy individuals considered to be at low risk for atherosclerosis and CVD. Further studies are needed to confirm the present findings.
  • Shin-ya Nagasawa, Takayoshi Ohkubo, Kamal Masaki, Emma Barinas-Mitchell, Katsuyuki Miura, Todd B. Seto, Aiman El-Saed, Takashi Kadowaki, Bradley J. Willcox, Daniel Edmundowicz, Aya Kadota, Rhobert W. Evans, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Marianne H. Bertolet, Tomonori Okamura, Yasuyuki Nakamura, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 22 6 590 - 598 2015年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians. Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models. Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all < 0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC. Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.
  • Takumi Hirata, Aya Higashiyama, Yoshimi Kubota, Kunihiro Nishimura, Daisuke Sugiyama, Aya Kadota, Yoko Nishida, Hironori Imano, Tomofumi Nishikawa, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    Journal of epidemiology 25 6 407 - 14 2015年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Several studies have reported that insulin resistance was a major risk factor for the onset of type 2 diabetes mellitus in individuals without diabetes or obesity. We aimed to clarify the association between insulin resistance and glycemic control in Japanese subjects without diabetes or obesity. METHODS: We conducted a community-based cross-sectional study including 1083 healthy subjects (323 men and 760 women) in an urban area. We performed multivariate regression analyses to estimate the association between the homeostasis model assessment of insulin resistance (HOMA-IR) values and markers of glycemic control, including glycated haemoglobin (HbA1c), 1,5-anhydroglucitol (1,5-AG), and fasting plasma glucose (FPG) levels, after adjustment for potential confounders. RESULTS: Compared with the lowest tertile of HOMA-IR values, the highest tertile was significantly associated with HbA1c and FPG levels after adjustment for potential confounders, both in men (HbA1c: β = 1.83, P = 0.001; FPG: β = 0.49, P < 0.001) and women (HbA1c: β = 0.82, P = 0.008; FPG: β = 0.39, P < 0.001). The highest tertile of HOMA-IR values was inversely associated with 1,5-AG levels compared with the lowest tertile (β = -18.42, P = 0.009) only in men. CONCLUSIONS: HOMA-IR values were associated with markers of glycemic control in Japanese subjects without diabetes or obesity. Insulin resistance may influence glycemic control even in a lean, non-diabetic Asian population.
  • Sayuki Torii, Hisatomi Arima, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saito, Naoko Miyagawa, Maryam Zaid, Yoshitaka Murakami, Robert D. Abbott, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 22 12 1266 - 1277 2015年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: Pulse wave velocity (PWV) is a simple and valid clinical method for assessing arterial stiffness. Coronary artery calcification (CAC) is an intermediate stage in the process leading to overt cardiovascular disease (CVD) and an established determinant of coronary artery disease. This study aimed to examine the association between PWV and CAC in a population-based sample of Japanese men. Methods: This is a cross-sectional study of 986 randomly selected men aged 40-79 years from Shiga, Japan. CVD-free participants were examined from 2006 to 2008. Brachial-ankle PWV (baPWV) was measured using an automatic waveform analyzer. CAC was assessed using computed tomography. Agatston scores >= 10 were defined as the presence of CAC. Results: Prevalence of CAC progressively increased with rising levels of baPWV: 20.6%, 41.7%, 56.3%, and 66.7% across baPWV quartiles < 1378, 1378-1563, 1564-1849, and > 1849 cm/s (P < 0.001 for trend). Associations remained significant after adjusting for age and other factors, including body mass index, systolic blood pressure, pulse rate, total and high-density lipoprotein cholesterol, hemoglobin A1c, drinking, smoking and exercise status, and the use of medication to treat hypertension, dyslipidemia and diabetes (P = 0.042 for trend). The optimal cutoff level of baPWV to detect CAC was 1612 cm/s using receiver operating characteristic curve analysis. Conclusions: Arterial stiffness as defined by an elevated baPWV is associated with an increased prevalence of CAC in a general population-based setting among Japanese men.
  • Taku Inohara, Shun Kohsaka, Tomonori Okamura, Makoto Watanabe, Yasuyuki Nakamura, Aya Higashiyama, Aya Kadota, Nagako Okuda, Yoshitaka Murakami, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 21 12 1501 - 1508 2014年12月 [有り][無し]
     研究論文(学術雑誌) 
    Aims Various cohort studies have shown a close association between long-term cardiovascular disease (CVD) outcomes and individual electrocardiographic (ECG) abnormalities such as axial, structural, and repolarization changes. The combined effect of these ECG abnormalities, each assumed to be benign, has not been thoroughly investigated. Methods and Results Community-dwelling Japanese residents from the National Integrated Project for Perspective Observation of Non-Communicable Disease and its Trends in the Aged, 1980-2004 and 1990-2005 (NIPPON DATA80 and 90), were included in this study. Baseline ECG findings were classified using the Minnesota Code and categorized into axial (left axis deviation, clockwise rotation), structural (left ventricular hypertrophy, atrial enlargement), and repolarization (minor and major ST-T changes) abnormalities. The hazard ratios of the cumulative impacts of ECG findings on long-term CVD death were estimated by stratified Cox proportional hazard models, including adjustments for cohort strata. In all, 16,816 participants were evaluated. The average age was 51.213.5 years; 42.7% participants were male. The duration of follow up was 300,924 person-years (mean 17.9 +/- 5.8 years); there were 1218 CVD deaths during that time. Overall, 4203 participants (25.0%) had one or more categorical ECG abnormalities: 3648 (21.7%) had a single abnormality, and 555 (3.3%) had two or more. The risk of CVD mortality increased as the number of abnormalities accumulated (single abnormality HR 1.29, 95% CI 1.13-1.48; 2 abnormalities HR 2.10, 95% CI 1.73-2.53). Conclusions Individual ECG abnormalities had an additive effect in predicting CVD outcome risk in our large-scale cohort study.
  • Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima
    ATHEROSCLEROSIS 236 2 237 - 243 2014年10月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the coronary atherosclerotic burden is low. We examined whether NMR-based lipoprotein particle profiles are associated with CAC, and compared them with standard lipid and lipid ratios in the Japanese general population. Methods and Results: We conducted a cross-sectional study in 851 men aged 40-79 years without cardiovascular diseases and lipid-lowering therapies. Adjusted odds ratios (ORs) (95% confidence intervals) for the top versus the bottom quartile of NMR-measured particle concentrations were 2.01 (1.24-3.23) for low-density lipoprotein (LDL-P), 1.04 (0.62-1.75) for high-density lipoprotein (HDL-P), 1.82 (1.13-2.95) for very-low-density lipoprotein (VLDL-P), and 1.92 (1.18-3.17) for LDL-P/HDL-P ratio. Similarly adjusted ORs of NMR-measured particle sizes were 0.59 (0.36-0.97) for LDL-P, 0.66 (0.40-1.10) for HDL-P, and 0.67 (0.40-1.12) for VLDL-P. The corresponding ORs were 1.82 (1.14-2.90) for total cholesterol (TC), 2.06 (1.28-3.30) for low-density lipoprotein cholesterol (LDL-C), 0.56 (0.34-0.91) for high-density lipoprotein cholesterol (HDL-C), 2.02 (1.24-3.29) for triglycerides, 2.08 (1.29-3.36) for non-high-density lipoprotein cholesterol (non-HDL-C), 2.27 (1.37-3.78) for TC/HDL-C ratio, and 1.73 (1.06-2.85) for LDL-C/HDL-C ratio. After mutual adjustment for total LDL-P concentration and TC/HDL-C ratio or non-HDL-C, LDL-P was no longer associated, whereas TC/HDL-C ratio remained significantly associated with CAC. Conclusions: In community-based Japanese men, the overall association of CAC with NMR-measured lipoprotein indices is comparable, but not superior, to that with standard lipids. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
  • Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima
    JOURNAL OF CARDIOLOGY 64 3-4 218 - 224 2014年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Increased resting heart rate (RHR) independently predicts cardiovascular mortality. Meanwhile, long-chain n-3 fatty acids (LCn3FAs) have a cardioprotective effect. Our aim was to evaluate whether higher LCn3FAs intake attenuates the elevated risk of cardiovascular mortality associated with increased RHR. Methods: We conducted a population-based 24-year prospective cohort study of Japanese, whose LCn3FAs intake is relatively high. Study participants included 8807 individuals aged 30-95 years from randomly selected areas across Japan without cardiovascular diseases and anti-hypertensive drugs at baseline. The primary endpoint was cardiovascular mortality, and the secondary endpoints were cardiac and stroke mortality during 24 years of follow-up. Individual dietary LCn3FAs intake was estimated from household-based 3-day weighed food records. RHR was obtained from 3 consecutive R-wave intervals on 12-lead electrocardiography. Cox models were used to estimate the multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) adjusting for possible confounders. Results: During the follow-up period, 617 cardiovascular deaths were observed. The median daily intake of LCn3FAs was 0.37% kcal (0.86 g/day). The interaction between dietary LCn3FAs intake and RHR in the risk of cardiovascular mortality was statistically significant (p = 0.033). The risk of cardiovascular mortality was significantly higher in the low-intake group (<0.37% kcal) with an RHR >85 beats/min (bpm) [hazard ratio (HR), 1.67; 95% confidence interval (CI), 1.15-2.43], but not in the high-intake group (>= 0.37% kcal) with an RHR >85 bpm (HR, 0.92; 95% CI, 0.61-1.38), compared with those in the high-intake group with an RHR <70 bpm. Similar results were observed with stroke mortality, but not with cardiac mortality. Conclusions: The risk of cardiovascular mortality associated with increased RHR is elevated in participants with low dietary LCn3FAs intake, but not in participants with high dietary LCn3FAs intake in a representative Japanese general population. These results suggest that high dietary LCn3FAs intake may prevent cardiovascular mortality associated with increased RHR. (C) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
  • N. Takashima, T. C. Turin, K. Matsui, N. Rumana, Y. Nakamura, A. Kadota, Y. Saito, H. Sugihara, Y. Morita, M. Ichikawa, K. Hirose, K. Kawakani, N. Hamajima, K. Miura, H. Ueshima, Y. Kita
    JOURNAL OF HUMAN HYPERTENSION 28 5 323 - 327 2014年05月 [無し][無し]
     研究論文(学術雑誌) 
    Brachial-ankle pulse wave velocity (baPWV) is a non-invasive measure of arterial stiffness obtained using an automated system. Although baPWVs have been widely used as a non-invasive marker for evaluation of arterial stiffness, evidence for the prognostic value of baPWV in the general population is scarce. In this study, we assessed the association between baPWV and future cardiovascular disease (CVD) incidence in a Japanese population. From 2002 to 2009, baPWV was measured in a total of 4164 men and women without a history of CVD, and they were followed up until the end of 2009 with a median follow-up period of 6.5 years. Hazard ratios (HRs) for CVD incidence according to baPWV levels were calculated using a Cox proportional hazards model adjusted for potential confounding factors, including seated or supine blood pressure (BP). During the follow-up period, we observed 40 incident cases of CVD. In multivariable-adjusted model, baPWV as a continuous variable was not significantly associated with future CVD risk after adjustment for supine BP. However, compared with lower baPWV category (<18 ms(-1)), higher baPWV (>= 18.0 ms(-1)) was significantly associated with an increased CVD risk (HR: 2.70, 95% confidence interval: 1.18-6.19). Higher baPWV (>= 18.0 ms(-1)) would be an independent predictor of future CVD event in the general Japanese population.
  • 宮川 尚子, 門田 文, 清水 めぐみ
    厚生の指標 61 4 28 - 34 厚生労働統計協会 2014年04月 [無し][無し]
  • Akira Sekikawa, Katsuyuki Miura, Sunghee Lee, Akira Fujiyoshi, Daniel Edmundowicz, Takashi Kadowaki, Rhobert W. Evans, Sayaka Kadowaki, Kim Sutton-Tyrrell, Tomonori Okamura, Marnie Bertolet, Kamal H. Masaki, Yasuyuki Nakamura, Emma J. M. Barinas-Mitchell, Bradley J. Willcox, Aya Kadota, Todd B. Seto, Hiroshi Maegawa, Lewis H. Kuller, Hirotsugu Ueshima
    HEART 100 7 569 - 573 2014年04月 [有り][無し]
     研究論文(学術雑誌) 
    Objective To determine whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA. Methods In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40-49years at baseline (2002-2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007-2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline. Results Mean (SD) serum percentage of LCn3PUFA was >100% higher in Japanese men than in white men (9.08 (2.49) vs 3.84 (1.79), respectively, p<0.01). Japanese men had a significantly lower incidence rate of CAC compared to white men (0.9 vs 2.9/100 person-years, respectively, p<0.01). The incidence rate ratio of CAC taking follow-up time into account between Japanese and white men was 0.321 (95% CI 0.150 to 0.690; p<0.01). After adjusting for age, systolic blood pressure, low density lipoprotein cholesterol, diabetes, and other potential confounders, the ratio remained significant (0.262, 95% CI 0.094 to 0.731; p=0.01). After further adjusting for LCn3PUFAs, however, the ratio was attenuated and became non-significant (0.376, 95% CI 0.090 to 1.572; p=0.18). Conclusions LCn3PUFAs significantly contributed to the difference in the incidence of CAC between Japanese and white men.
  • Yuan Lu, Kaveh Hajifathalian, Majid Ezzati, Mark Woodward, Eric B. Rimm, Goodarz Danaei
    LANCET 383 9921 970 - 983 2014年03月 [無し][無し]
     研究論文(学術雑誌) 
    Background Body-mass index (BMI) and diabetes have increased worldwide, whereas global average blood pressure and cholesterol have decreased or remained unchanged in the past three decades. We quantified how much of the effects of BMI on coronary heart disease and stroke are mediated through blood pressure, cholesterol, and glucose, and how much is independent of these factors. Methods We pooled data from 97 prospective cohort studies that collectively enrolled 1.8 million participants between 1948 and 2005, and that included 57 161 coronary heart disease and 31 093 stroke events. For each cohort we excluded participants who were younger than 18 years, had a BMI of lower than 20 kg/m(2), or who had a history of coronary heart disease or stroke. We estimated the hazard ratio (HR) of BMI on coronary heart disease and stroke with and without adjustment for all possible combinations of blood pressure, cholesterol, and glucose. We pooled HRs with a random-effects model and calculated the attenuation of excess risk after adjustment for mediators. Findings The HR for each 5 kg/m(2) higher BMI was 1.27 (95% CI 1.23-1.31) for coronary heart disease and 1.18 (1.14-1.22) for stroke after adjustment for confounders. Additional adjustment for the three metabolic risk factors reduced the HRs to 1.15 (1.12-1.18) for coronary heart disease and 1.04 (1.01-1.08) for stroke, suggesting that 46% (95% CI 42-50) of the excess risk of BMI for coronary heart disease and 76% (65-91) for stroke is mediated by these factors. Blood pressure was the most important mediator, accounting for 31% (28-35) of the excess risk for coronary heart disease and 65% (56-75) for stroke. The percentage excess risks mediated by these three mediators did not differ significantly between Asian and western cohorts (North America, western Europe, Australia, and New Zealand). Both overweight (BMI >= 25 to < 30 kg/m(2)) and obesity (BMI >= 30 kg/m(2)) were associated with a significantly increased risk of coronary heart disease and stroke, compared with normal weight (BMI >= 20 to < 25 kg/m(2)), with 50% (44-58) of the excess risk of overweight and 44% (41-48) of the excess risk of obesity for coronary heart disease mediated by the selected three mediators. The percentages for stroke were 98% (69-155) for overweight and 69% (64-77) for obesity. Interpretation Interventions that reduce high blood pressure, cholesterol, and glucose might address about half of excess risk of coronary heart disease and three-quarters of excess risk of stroke associated with high BMI. Maintenance of optimum bodyweight is needed for the full benefits.
  • Longjian Liu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Yasuyuki Nakamura, Takayoshi Ohkubo, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
    AMERICAN JOURNAL OF CARDIOLOGY 113 1 84 - 89 2014年01月 [有り][無し]
     研究論文(学術雑誌) 
    The United States has a higher prevalence of metabolic syndrome (MS) and cardiovascular disease (CVD) mortality than Japan, but it is unknown how much of the difference in MS accounts for the mortality difference. The aim of this study was to examine the impact of MS on the excess CVD mortality in the United States compared with that in Japan. Data from the United States Third National Health and Nutrition Examination Survey (NHANES 111; n = 12,561) and the Japanese National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in Aged (NIPPON DATA; n = 7,453) were analyzed. MS was defined as of 5 risk factors (obesity, high blood pressure, decreased high-density lipoprotein cholesterol, elevated glycosylated hemoglobin, and elevated triglycerides). The results show that after a median of 13.8 years of follow-up in the United States, 1,683 patients died from CVD (11.75 per 1,000 person-years), and after a median of 15 years of follow-up in Japan, 369 patients died from CVD (3.56 per 1,000 person-years). The age-adjusted prevalence of MS was 26.7% in the United States and 19.3% in Japan. Of 5 MS factors, obesity, high blood pressure, elevated triglycerides, and glycosylated hemoglobin in the United States, and high blood pressure and elevated glycosylated hemoglobin in Japan were significant risk factors for CVD mortality. Estimates of 13.3% and 44% of the excess CVD mortality for the United States could be explained by the higher prevalence of MS and MS plus baseline CVD history than in Japan. In conclusion, the present study is the first to quantitatively demonstrate that MS and MS plus baseline CVD history may significantly contribute to the explanation of excess CVD mortality in the United States compared with Japan. (C) 2014 Elsevier Inc. All rights reserved.
  • Masaru Sakurai, Shigeyuki Saitoh, Katsuyuki Miura, Hideaki Nakagawa, Hirofumi Ohnishi, Hiroshi Akasaka, Aya Kadota, Yoshikuni Kita, Takehito Hayakawa, Takayoshi Ohkubo, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
    DIABETES CARE 36 11 3759 - 3765 2013年11月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVEAssociations between HbA(1c) and cardiovascular diseases (CVD) have been reported mainly in Western countries. It is not clear whether HbA(1c) measurements are useful for assessing CVD mortality risk in East Asian populations.RESEARCH DESIGN AND METHODSThe risk for cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. A total of 7,120 participants (2,962 men and 4,158 women; mean age 52.3 years) free of previous CVD were followed for 15 years. Adjusted hazard ratios (HRs) and 95% CIs among categories of HbA(1c) (<5.0%, 5.0-5.4%, 5.5-5.9%, 6.0-6.4%, and 6.5%) for participants without treatment for diabetes and HRs for participants with diabetes were calculated using a Cox proportional hazards model.RESULTSDuring the study, there were 1,104 deaths, including 304 from CVD, 61 from coronary heart disease, and 127 from stroke (78 from cerebral infarction, 25 from cerebral hemorrhage, and 24 from unclassified stroke). Relations to HbA(1c) with all-cause mortality and CVD death were graded and continuous, and multivariate-adjusted HRs for CVD death in participants with HbA(1c) 6.0-6.4% and 6.5% were 2.18 (95% CI 1.22-3.87) and 2.75 (1.43-5.28), respectively, compared with participants with HbA(1c) <5.0%. Similar associations were observed between HbA(1c) and death from coronary heart disease and death from cerebral infarction.CONCLUSIONSHigh HbA(1c) levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.
  • Akira Fujiyoshi, Akira Sekikawa, Chol Shin, Kamal Masaki, J. David Curb, Takayoshi Ohkubo, Katsuyuki Miura, Takashi Kadowaki, Sayaka Kadowaki, Aya Kadota, Daniel Edmundowicz, Amber Shah, Rhobert W. Evans, Marianne Bertolet, Jina Choo, Bradley J. Willcox, Tomonori Okamura, Hiroshi Maegawa, Kiyoshi Murata, Lewis H. Kuller, Hirotsugu Ueshima
    European Heart Journal Cardiovascular Imaging 14 9 921 - 927 2013年09月 [有り][無し]
     研究論文(学術雑誌) 
    AimsConflicting evidence exists regarding whether obesity is independently associated with coronary artery calcium (CAC), a measure of coronary atherosclerosis. We examined an independent association of obesity with prevalent CAC among samples of multi-ethnic groups whose background populations have varying levels of obesity and coronary heart disease (CHD).Methods and resultsWe analysed a population-based sample of 1212 men, aged 40-49 years free of clinical cardiovascular disease recruited in 2002-06 310 Japanese in Japan (JJ), 294 Koreans in South Korea (KN), 300 Japanese Americans (JA), and 308 Whites in the USA (UW). We defined prevalent CAC as an Agatston score of ≥10. Prevalent CAC was calculated by tertile of the body mass index (BMI) in each ethnic group and was plotted against the corresponding median of tertile BMI. Additionally, logistic regression was conducted to examine whether an association of the BMI was independent of conventional risk factors. The median BMI and crude prevalence of CAC for JJ, KN, JA, and UW were 23.4, 24.4, 27.4, and 27.1 (kg/m2) 12, 11, 32, and 26 (%), respectively. Despite the absolute difference in levels of BMI and CAC across groups, higher BMI was generally associated with higher prevalent CAC in each group. After adjusting for age, smoking, alcohol, hypertension, lipids, and diabetes mellitus, the BMI was positively and independently associated with prevalent CAC in JJ, KN, UW, but not in JA.ConclusionIn this multi-ethnic study, obesity was independently associated with subclinical stage of coronary atherosclerosis among men aged 40-49 years regardless of the BMI level. © 2013 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013.
  • Yasuyuki Nakamura, Tomonori Okamura, Taku Inohara, Shun Kohsaka, Makoto Watanabe, Aya Higashiyama, Aya Kadota, Nagako Okuda, Takayoshi Ohkubo, Shin-Ya Nagasawa, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    Journal of Electrocardiology 46 4 360 - 365 2013年07月 [有り][無し]
     研究論文(学術雑誌) 
    Aims Left bundle branch block (LBBB) is generally considered to be associated with a poorer prognosis in comparison with normal controls. However, there are some studies that showed no difference in prognosis of LBBB in comparison with normal controls. Methods and Results We studied prognostic values of BBBs on cardiovascular disease (CVD) and total mortality using the NIPPON DATA80 database with a 24-year follow-up. At the baseline in 1980, data were collected on study participants, ages 30 years and over, from randomly selected areas in Japan. We followed 9,090 participants (44% men, mean age 51). During the 24 year follow-up, there were 886 CVD, and 2,597 total mortality cases. Among participants, 0.2% of them were in LBBB, 1.3% in RBBB, 4.3% in other ventricular conduction defect (VCD) groups. The multivariate-adjusted hazard ratio (HR) using the Cox model including biochemical and other ECG variables revealed that LBBB was significantly positively associated with CVD (HR = 2.71, 95% confidence intervals [CI]: 1.35-5.45, P = 0.005), and total (HR = 2.07, 95%CI: 1.26-3.39, P = 0.004) mortality in men and women combined compared to participants without VCD. RBBB and other VCDs did not carry any significant risk for CVD or total mortality. Conclusions We found significant positive associations of LBBB with CVD and total mortality independent of confounding factors including other ECG changes. © 2013 Elsevier Inc.
  • Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima
    HEART 99 14 1024 - 1029 2013年07月 [有り][無し]
     研究論文(学術雑誌) 
    Objective Higher marine-derived n-3 fatty acids (MDn3FAs) intake reduces the risk of sudden cardiac death via antiarrhythmic effects. The article evaluates whether MDn3FAs intake attenuates the increased risk of cardiac death associated with J-point elevation (JPE), characterised by an elevation of QRS-ST junction (J-point) >= 0.1 mV on electrocardiography. Design A prospective population-based cohort study. Setting The National Survey on Circulatory Disorders and the National Nutrition Survey of Japan. Participants A total of 4348 community-dwelling men (mean age 49.3 years), without cardiovascular diseases at baseline, from randomly selected areas across Japan. Main outcome measures Cardiac death (200 men) during the 24-year follow-up. Results Dietary MDn3FAs intake was assessed using a dietary method to estimate individual intake of household-based weighed food records for 3 days. Cox models were used to calculate HRs and 95% CIs adjusted for possible confounding factors. JPE was present in 340 participants (7.8%). The median daily intake of MDn3FAs was 0.35% kcal (0.92 g/day). The risk of cardiac death was significantly higher in participants with JPE than in those without JPE in the low intake group (<0.35% kcal; adjusted HR 3.51; 95% CI 1.84 to 6.73; p<0.001), but not in the high intake group (>= 0.35% kcal; adjusted HR 1.09; 95% CI 0.56 to 2.16; p=0.795). The interaction between dietary MDn3FAs intake and JPE on the risk of cardiac death was statistically significant (p=0.006). Conclusions The increased risk of cardiac death associated with JPE may be attenuated by higher dietary MDn3FAs intake.
  • Tomonori Okamura, Akira Sekikawa, Tatsuya Sawamura, Takashi Kadowaki, Emma Barinas-Mitchell, Rachel H. Mackey, Aya Kadota, Rhobert W. Evans, Daniel Edmundowicz, Aya Higashiyama, Yasuyuki Nakamura, Robert D. Abbott, Katsuyuki Miura, Akira Fujiyoshi, Yoshiko Fujita, Yoshitaka Murakami, Naomi Miyamatsu, Akemi Kakino, Hiroshi Maegawa, Kiyoshi Murata, Minoru Horie, Kenichi Mitsunami, Atsunori Kashiwagi, Lewis H. Kuller, Hirotsugu Ueshima
    ATHEROSCLEROSIS 229 1 240 - 245 2013年07月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC), total LDL particles and usual measurement of oxidized LDL. The association between LAB and intima-media thickness (IMT) of carotid artery was investigated by ultrasound in US and Japan men. Methods: Participants were 297 US Caucasian and 310 Japanese men, aged 40-49 years without past history of cardiovascular disease. Serum LAB levels were measured by ELISAs with recombinant LOX-1 and monoclonal anti-apolipoprotein B antibody. Results: Serum LAB levels [median (interquartile range), mu g/L] were 1321 (936, 1730) in US Caucasians and 940 (688, 1259) in Japanese. For Caucasian men, average IMT was higher in higher LAB quartile, which was 0.653, 0.667, 0.688, and 0.702 mm, respectively (p for trend = 0.02). Linear regression analysis showed serum LAB was significantly associated with IMT after adjustment for LDLC or total LDL particles in addition to other traditional or novel risk factors for atherosclerosis such as C-reactive protein. However, there was no significant relationship between LAB and IMT in Japanese men. Conclusion: Serum LAB, a new candidate biomarker for residual risk, was associated with an increased carotid IMT in US Caucasian men independently of various risk factors; however, ethnic difference should be clarified in the future. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
  • Koichiro Azuma, J. David Curb, Takashi Kadowaki, Daniel Edmundowicz, Sayaka Kadowaki, Kamal H. Masaki, Aiman El-Saed, Yoshihiko Nishio, Todd B. Seto, Tomonori Okamura, Cemal Cetinel, Aya Kadota, Kim Sutton-Tyrrell, Katsuyuki Miura, Rhobert W. Evans, Tomoko Takamiya, Hiroshi Maegawa, Iva Miljkovic, Lewis H. Kuller, Hirotsugu Ueshima, David E. Kelley, Akira Sekikawa
    OBESITY RESEARCH & CLINICAL PRACTICE 7 3 E198 - E205 2013年05月 [有り][無し]
     研究論文(学術雑誌) 
    Background: We recently reported that Japanese had higher liver fat at a lower level of BMI compared with non-Hispanic whites (NHW). Objective: We hypothesize that ethnic difference in fat storage capacity contributes to this ethnic difference in liver fat. Design: To examine this, we assessed liver fat among 244 Japanese-American aged 40-49, using regional computed-tomography images, along with metabolic variables. Results: Despite the similar BMI between Japanese-Americans and NHW men, Japanese-Americans had more liver fat (liver to spleen attenuation ratio: 1.03 +/- 0.22 for Japanese-Americans, and 1.07 +/- 0.15 for NHW men; p < 0.05) and tended to have a greater disposition for fatty liver with an increase in BMI than NHW, indicating a clear difference between the two groups. In addition, liver fat is less in Japanese-Americans compared with Japanese men (1.03 +/- 0.22 vs. 1.01 +/- 0.16; p < 0.05), despite of a much higher BMI. These ethnic differences support the hypothesis that higher fat storage capacity indeed seems to be associated with less liver fat. In all the groups, liver fat content strongly correlated with triglycerides, homeostasis model assessment-insulin resistance, and C-reactive protein (CRP). Nevertheless, these metabolic variables were worse in Japanese-Americans, despite of less liver fat, compared with Japanese. Moreover, CRP levels were least among Japanese with highest liver fat, and highest among NHW men with least liver fat, despite of a strong positive association between CRP and fatty liver within each population. Conclusions: Fat content in the liver is intermediate for Japanese-Americans compared with Japanese and NHW men, which supports the hypothesis of less fat storage capacity among Japanese, closely linked to ethnic difference in predisposition to fatty liver. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
  • 一般日本人集団において非HDLコレステロールは冠動脈石灰化と強く関連する SESSA(Non-HDL Cholesterol is Strongly Associated with Coronary Artery Calcification in a General Japanese Population: SESSA)
    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Fujiyoshi Akira, Kadota Aya, Kadowaki Sayaka, Yamamoto Takashi, Miyagawa Naoko, Torii Sayuki, Saitoh Yoshino, Takashima Naoyuki, Murakami Yoshitaka, Okamura Tomonori, Horie Minoru, Ueshima Hirotsugu
    Circulation Journal 77 Suppl.I 123 - 123 2013年03月
  • 長鎖n-3系脂肪酸の食事による高摂取は心血管疾患死亡リスクに関係する安静時心拍数増加の影響を軽減させる(Higher Dietary Long-chain n-3 Fatty Acids Attenuated the Effect of Higher Resting Heart Rate on the Risk of Cardiovascular Mortality)
    Hisamatsu Takashi, Miura Katsuyuki, Ohkubo Takayoshi, Yamamoto Takashi, Miyagawa Naoko, Fujiyoshi Akira, Kadota Aya, Takashima Naoyuki, Okuda Nagako, Murakami Yoshitaka, Okamura Tomonori, Horie Minoru, Okayama Akira, Ueshima Hirotsugu
    Circulation Journal 77 Suppl.I 259 - 260 2013年03月
  • Hiroshi Yamamoto, Kazuhisa Maeda, Yoshitaka Uji, Hiroshi Tsuchihashi, Tsuyoshi Mori, Tomoharu Shimizu, Yoshihiro Endo, Aya Kadota, Katsuyuki Miura, Yusuke Koga, Toshinori Ito, Tohru Tani
    PLOS ONE 8 3 e56129  2013年03月 [有り][無し]
     研究論文(学術雑誌) 
    Background and Purpose: Infections are important causes of postoperative morbidity after gastric surgery; currently, no factors have been identified that can predict postoperative infection. Adiponectin (ADN) mediates energy metabolism and functions as an immunomodulator. Perioperative ADN levels and perioperative immune functioning could be mutually related. Here we evaluated a potential biological marker to reliably predict the incidence of postoperative infections to prevent such comorbidities. Methods: We analyzed 150 consecutive patients who underwent elective gastric cancer surgery at the Shiga University of Medical Science Hospital (Shiga, Japan) from 1997 to 2009; of these, most surgeries (n = 100) were performed 2008 onwards. The patient characteristics and surgery-related factors between two groups (with and without infection) were compared by the paired t-test and chi(2) test, including preoperative ADN levels, postoperative day 1 ADN levels, and ADN ratio (postoperative ADN levels/preoperative ADN levels) as baseline factors. Logistic regression analysis was performed to access the independent association between ADN ratio and postoperative infection. Finally, receiver operating curves (ROCs) were constructed to examine its clinical utility. Results: Sixty patients (40%) experienced postoperative infections. The baseline values of age, American Society of Anesthesiologists physical status, total operating time, blood loss, surgical procedure, C-reactive protein (CRP) levels, preoperative ADN levels, and ADN ratio were significantly different between groups. Logistic regression analysis using these factors indicated that type 2 diabetes mellitus (T2DM) and ADN ratio were significantly independent variables (*p<0.05, ** p<0.01, respectively). ROC analysis revealed that the useful cutoff values (sensitivity/specificity) for preoperative ADN levels, ADN ratio, blood loss, operating time, and CRP levels were 8.81(0.567/0.568), 0.76 (0.767/0.761), 405 g (0.717/0.693), 342 min (0.617/0.614), and 8.94 mg/dl (0.583/0.591), respectively. Conclusion: T2DM and ADN ratio were independent predictors of postoperative infection and ADN ratio was the most useful predictor for postoperative infection.
  • Nobutaka Hirooka, Takashi Kadowaki, Akira Sekikawa, Hirotsugu Ueshima, Jina Choo, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Sayaka Kadowaki, Aya Kadota, Yasuyuki Nakamura, Hiroshi Maegawa, Atsunori Kashiwagi, Kamal Masaki, Kim Sutton-Tyrrell, Lewis H. Kuller, J. David Curb, Chol Shin
    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH 67 2 119 - 124 2013年02月 [有り][無し]
     研究論文(学術雑誌) 
    Background Cigarette smoking is a risk factor of coronary heart disease. Vascular calcification such as coronary artery calcium (CAC) and aortic calcium (AC) is associated with coronary heart disease. The authors hypothesised that cigarette smoking is associated with coronary artery and aortic calcifications in Japanese and Koreans with high smoking prevalence. Methods Random samples from populations of 313 Japanese and 302 Korean men aged 40-49 years were examined for calcification of the coronary artery and aorta using electron beam CT. CAC and AC were quantified using the Agatston score. The authors examined the associations of cigarette smoking with CAC and AC after adjusting for conventional risk factors and alcohol consumption. Current and past smokers were combined and categorised into two groups using median pack-years as a cut-off point in each of Japanese and Koreans. The never-smoker group was used as a reference for the multiple logistic regression analyses. Results The ORs of CAC (score >= 10) for smokers with higher pack-years were 2.9 in Japanese (p<0.05) and 1.3 in Koreans (non-significant) compared with never-smokers. The ORs of AC (score >= 100) for smokers with higher pack-years were 10.4 in Japanese (p<0.05) and 3.6 in Koreans (p<0.05). Conclusion Cigarette smoking with higher pack-years is significantly associated with CAC and AC in Japanese men, while cigarette smoking with higher pack-years is significantly associated with AC but not significantly with CAC in Korean men.
  • Takashi Hisamatsu, Takayoshi Ohkubo, Katsuyuki Miura, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Shin-ya Nagasawa, Yoshikuni Kita, Yoshitaka Murakami, Akira Okayama, Minoru Horie, Tomonori Okamura, Hirotsugu Ueshima
    Circulation Journal 77 5 1260 - 1266 2013年 [有り][無し]
     研究論文(学術雑誌) 
    Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). Methods and Results: To investigate the association between the presence of J-point elevation ≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54 95% confidence interval [CI] 1.40-4.58 P=0.002) and death from CAD (adjusted HR, 4.66 95% CI 2.30-9.46 P< 0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (< 60 years) than in older individuals (≥60 years) (all P for interaction < 0.05). Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.
  • Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Kadowaki, Naoyuki Takashima, Takashi Hisamatsu, Yasuyuki Nakamura, Fumiyoshi Kasagi, Hiroshi Maegawa, Atsunori Kashiwagi, Hirotsugu Ueshima
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 20 10 755 - 766 2013年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: To examine whether subclinical atherosclerosis of the carotid arteries is concordant with the categories in the 2012 atherosclerosis prevention guidelines proposed by the Japan Atherosclerosis Society (JAS guidelines 2012), which adopted the estimated 10-year absolute risk of coronary artery disease (CAD) death in the NIPPON DATA80 Risk Assessment Chart. Methods: Between 2006 and 2008, 868 Japanese men 40 to 74 years of age without a history of cardiovascular disease were randomly selected from Kusatsu City, Japan. The intima media thickness (IMT) and plaque number from the common to internal carotid arteries were investigated using ultrasonography. The absolute risk of CAD death was estimated based on the individual risk factor data, and the mean IMT and plaque number in Categories I, II and III of the guidelines were examined. Results: The estimated 10-year absolute risk of CAD was directly related to the IMT (mean IMT (mean +/- SD) (mm) for a 10-year absolute risk of >= 2.0% and >= 5.0%: 0.88 +/- 0.18 and 0.95 +/- 0.19, respectively) and the plaque number. These results are compatible with the categories described by the guidelines (mean IMT (mean +/- SD) (mm) for Categories I, II, and III: 0.70 +/- 0.11, 0.81 +/- 0.16 and 0.88 +/- 0.18, respectively; mean plaque number: 0.9, 2.1 and 3, respectively). These findings were similar for Category. participants with or without DM and CKD. Conclusions: Subclinical atherosclerosis of the carotid arteries is concordant with the 10-year absolute risk of CAD and the categories in the JAS guidelines 2012.
  • Taku Inohara, Shun Kohsaka, Tomonori Okamura, Makoto Watanabe, Yasuyuki Nakamura, Aya Higashiyama, Aya Kadota, Nagako Okuda, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
    PloS one 8 11 e80853  2013年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Atrial premature complexes (APC) are among the most frequently encountered electrocardiographic abnormalities. However, their prognostic value among healthy individuals is unclear. This study aimed to clarify the role of APC in predicting cardiovascular events in a large Japanese community cohort using long-term follow-up data. METHODS: National Integrated Project for Prospective Observation of Non-communicable Disease And its Trends in the Aged, 1990-2005, (NIPPON DATA 90) was a large cohort study of cardiovascular disease (CVD) in Japan. A total of 7692 otherwise healthy participants with no history of myocardial infarction, stroke, atrial fibrillation, or atrial flutter were enrolled (men, 41.5%; mean age, 52.5 ± 13.7 years). RESULTS: A total of 64 (0.8%) participants had at least one beat of APC on screening 12-lead electrocardiogram. During the follow-up of 14.0 ± 2.9 years (total, 107,474 patient-years), 338 deaths occurred due to CVD. The association between APC and CVD outcome was assessed using Cox proportional hazard models. Cox regression analysis revealed that the presence of APC was an independent predictor for CVD deaths (HR: 2.03, 95% CI: 1.12-3.66, P = 0.019). The association of APC on CVD death was more evident in participants with hypertension (P-value for interaction, 0.03). CONCLUSIONS: APC recorded during the screening electrocardiogram are significantly associated with an increased risk of CVD deaths in a Japanese community-dwelling population and are a strong prognostic factor for hypertensive participants.
  • Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Kadowaki, Naoyuki Takashima, Takashi Hisamatsu, Yasuyuki Nakamura, Fumiyoshi Kasagi, Hiroshi Maegawa, Atsunori Kashiwagi, Hirotsugu Ueshima
    Journal of Atherosclerosis and Thrombosis 20 10 755 - 766 2013年 [無し][無し]
     研究論文(学術雑誌) 
    Aim: To examine whether subclinical atherosclerosis of the carotid arteries is concordant with the categories in the 2012 atherosclerosis prevention guidelines proposed by the Japan Atherosclerosis Society (JAS guidelines 2012), which adopted the estimated 10-year absolute risk of coronary artery disease (CAD) death in the NIPPON DATA80 Risk Assessment Chart. Methods: Between 2006 and 2008, 868 Japanese men 40 to 74 years of age without a history of cardiovascular disease were randomly selected from Kusatsu City, Japan. The intima media thickness (IMT) and plaque number from the common to internal carotid arteries were investigated using ultrasonography. The absolute risk of CAD death was estimated based on the individual risk factor data, and the mean IMT and plaque number in Categories I, II and III of the guidelines were examined. Results: The estimated 10-year absolute risk of CAD was directly related to the IMT (mean IMT (mean±SD) (mm) for a 10-year absolute risk of ≥2.0% and ≥5.0%: 0.88±0.18 and 0.95±0.19, respectively) and the plaque number. These results are compatible with the categories described by the guidelines (mean IMT (mean±SD) (mm) for Categories I, II, and III: 0.70±0.11, 0.81±0.16 and 0.88±0.18, respectively mean plaque number: 0.9, 2.1 and 3, respectively). These findings were similar for Category III participants with or without DM and CKD. Conclusions: Subclinical atherosclerosis of the carotid arteries is concordant with the 10-year absolute risk of CAD and the categories in the JAS guidelines 2012.
  • Naoyuki Takashima, Takayoshi Ohkubo, Katsuyuki Miura, Tomonori Okamura, Yoshitaka Murakami, Akira Fujiyoshi, Shin-ya Nagasawa, Aya Kadota, Yoshikuni Kita, Naoko Miyagawa, Takashi Hisamatsu, Takehito Hayakawa, Akira Okayama, Hirotsugu Ueshima
    JOURNAL OF HYPERTENSION 30 12 2299 - 2306 2012年12月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: In Western populations, blood pressure (BP) measured at baseline has been reported to predict long-term (over 20 years) risk of mortality from cardiovascular diseases (CVDs). However, corresponding evidence is scarce in Asia where stroke is dominant. We investigated the association between baseline BP and 24-year mortality risk due to CVD, in a representative Japanese general population. Methods: We followed up a nationwide sample of 8592 Japanese, aged 30 years or above without a history of CVD and antihypertensive medication at baseline, for 24 years. Hazard ratios for CVD mortality in BP categories defined according to JCN7 criteria were estimated using Cox model adjusted for potential confounding factors with normal BP treated as the reference category. Results: We observed 689 CVD deaths. Hazard ratios for CVD mortality were progressively and significantly increased from the category of prehypertension. Population-attributable fraction (PAF) demonstrated that 43 and 48% of CVD and stroke deaths were explained by non-normal BP at baseline. Hazard ratios and PAF were remarkably higher in younger participants (aged 30-59 years) than those in the elderly (aged 60 years or above). Particularly, in younger men, 81% of CVD deaths were explained by non-normal BP. In sensitivity analysis, participants with antihypertensive medication showed the highest hazard ratio for CVD morality compared with the other categories. Conclusions: BP levels above normal at baseline retained significant relative and absolute risks of CVD and stroke mortality during 24 years. Long-lasting burden of non-normal BP particularly in younger individuals suggests the importance of primary prevention of high BP from younger generation.
  • Akira Sekikawa, Laufey Steingrimsdottir, Hirotsugu Ueshima, Chol Shin, J. David Curb, Rhobert W. Evans, Alda M. Hauksdottir, Aya Kadota, Jina Choo, Kamal Masaki, Bolli Thorsson, Lenore J. Launer, Melisa E. Garcia, Hiroshi Maegawa, Bradley J. Willcox, Gudny Eiriksdottir, Akira Fujiyoshi, Katsuyuki Miura, Tamara B. Harris, Lewis H. Kuller, Vilmundur Gudnason
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 87 1 11 - 16 2012年07月 [有り][無し]
     研究論文(学術雑誌) 
    In the 1990s Iceland and Japan were known as countries with high fish consumption whereas coronary heart disease (CHD) mortality in Iceland was high and that in Japan was low among developed countries. We described recent data fish consumption and CHD mortality from publicly available data. We also measured CHD risk factors and serum levels of marine-derived n-3 and other fatty acids from population-based samples of 1324 men in Iceland, Japan, South Korea, and the US. CHD mortality in men in Iceland was almost 3 times as high as that in Japan and South Korea. Generally, a profile of CHD risk factors in Icelanders compared to Japanese was more favorable. Serum marine-derived n-3 fatty acids in Iceland were significantly lower than in Japan and South Korea but significantly higher than in the US. (C) 2012 Elsevier Ltd. All rights reserved.
  • Tanvir Chowdhury Turin, Yoshitaka Murakami, Katsuyuki Miura, Nahid Rumana, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Hirotsugu Ueshima, Akira Okayama, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Nagako Okuda, Toru Izumi, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Katsuyuki Miura, Takayoshi Ohkubo, Yoshikuni Kita, Aya Kadota, Yasuyuki Nakamura, Katsushi Yoshita, Kazunori Kodama, Fumiyoshi Kasagi, Yutaka Kiyohara
    Diabetes Research and Clinical Practice 96 2 e18 - e22 2012年05月 [有り][無し]
     研究論文(学術雑誌) 
    Life expectancy (LE) among the Japanese population with or without diabetes mellitus was estimated. LE in 40-year old men and women was 41.1 and 47.5. years in those without diabetes and 32.3 and 40.9. years in those with diabetes. The LE of 40-year old men and women with diabetes was 8.8 and 6.6. years shorter than in those without diabetes. Diabetes mellitus leads to a decrease in LE. The presence of impaired glucose tolerance also affected LE inversely. © 2012 Elsevier Ireland Ltd.
  • Yasuyuki Nakamura, Tomonori Okamura, Aya Higashiyama, Makoto Watanabe, Aya Kadota, Takayoshi Ohkubo, Katsuyuki Miura, Fumiyoshi Kasagi, Kazunori Kodama, Akira Okayama, Hirotsugu Ueshima
    CIRCULATION 125 10 1226 - 1233 2012年03月 [有り][無し]
     研究論文(学術雑誌) 
    Background-Although clockwise rotation and counterclockwise rotation are distinct findings of the ECG, their prognostic significance is rarely studied. Methods and Results-We studied prognostic values of clockwise and counterclockwise rotation on total, cardiovascular disease (CVD), and subtype mortality using the National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged, 1980-2004 (NIPPON DATA80) database with a 24-year follow-up. At baseline in 1980, data were collected on study participants aged >= 30 years from randomly selected areas in Japan. We followed 9067 participants (44% men; mean age, 51 years). During the 24-year follow-up, mortality was as follows: 2581 total, 887 CVD, 179 coronary heart disease, 173 heart failure, and 411 stroke. The multivariate-adjusted hazard ratio (HR) with the use of the Cox model including biochemical and other ECG variables revealed that clockwise rotation was significantly positively associated with heart failure in men and women combined (HR=1.79; 95% confidence interval [CI], 1.13-2.83; P=0.013), CVD in men and in men and women combined (HR=1.49; 95% CI, 1.12-1.98; P=0.007 in men; HR=1.28; 95% CI, 1.02-1.59; P=0.030 in combined), and total mortality in men and in men and women combined (HR=1.19; 95% CI, 1.00-1.49; P=0.0496 in men; HR=1.15; 95% CI, 1.00-1.32; P=0.045 in combined). Counterclockwise rotation was significantly inversely associated stroke in men and women combined (HR=0.77; 95% CI, 0.62-0.96; P=0.017), CVD in men and in men and women combined (HR=0.74; 95% CI, 0.59-0.94; P=0.011 in men; HR=0.81; 95% CI, 0.70-0.94; P=0.006 in combined), and total mortality in women (HR=0.87; 95% CI, 0.77-0.98; P=0.023). Conclusions-We found a significant positive association of clockwise rotation and a significant inverse association of counterclockwise rotation with CVD mortality in men and in men and women combined, independent of confounding factors including other ECG changes. (Circulation. 2012;125:1226-1233.)
  • Hassen LJ, Ueshima H, Curb JD, Choo J, Lee S, Masaki K, Kadowaki T, Shin C, Evans RW, Seto TB, Fujiyoshi A, Wilcox BJ, Sutton-Tyrrell K, Kadota A, El-Saed A, Miura K, Kuller LH, Sekikawa A
    Eur J Clin Nutr. 66 3 329 - 335 2012年 [無し][無し]
     研究論文(学術雑誌)
  • Aya Higashiyama, Ichiro Wakabayashi, Yoshimi Kubota, Yoshiko Adachi, Akiko Hayashibe, Kunihiro Nishimura, Daisuke Sugiyama, Aya Kadota, Hironori Imano, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 19 11 1027 - 1034 2012年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: High-sensitivity C-reactive protein (hs-CRP) identifies individuals at risk for cardiovascular disease (CVD) without an increased level of low-density lipoprotein cholesterol (LDL-C). The present study was performed to compare hs-CRP and LDL-C in association with the cardio-ankle vascular index (CAVI) in Japanese community dwellers considered to be at low risk for atherosclerosis from their level of traditional CVD risk factors. Methods: A community-based study involving 386 healthy Japanese (261 men and 125 women) without a history of CVD and medications for hypertension, diabetes, and dyslipidemia was performed. Multiple adjustments were performed with linear regression models to estimate the association between CAVI and hs-CRP or LDL-C levels. The participants were divided into four groups on the basis of whether they were above or below the median hs-CRP and LDL-C values, and CAVI was compared among the four groups by analysis of covariance after adjusting for confounders. Results: In multiple linear regression models, hs-CRP showed a significant positive association with CAVI; however, no clear association was observed between CAVI and LDL-C. These results were similar in the analyses among the participants with LDL-C < 140 mg/dL or hs-CRP < 1.0 mg/L. CAVI was higher in the groups with high hs-CRP than in those with low hs-CRP, irrespective of LDL-C; however, CAVI was highest in the group with high LDL-C and high hs-CRP. Conclusions: The present study suggests that hs-CRP could be a better risk factor assessor for atherosclerosis than LDL-C in individuals considered to be at low risk for atherosclerosis assessed by their traditional CVD risk factors. J Atheroscler Thromb, 2012; 19: 1027-1034.
  • Prognostic Values of Clockwise and Counter-Clockwise Rotation for Cardiovascular Mortality in Japanese (24 Year Follow-up of NIPPON DATA80)
    CIRCULATION 125 10 1226 - 1233 2012年 [無し][無し]
     研究論文(学術雑誌)
  • Influence of cigarette smoking on coronary and aortic calcification among population-based middle-aged Japanese and Korean men.
    Journal of Epidemiology and Community Health -- in press 2012年 [無し][無し]
     研究論文(学術雑誌)
  • Fatty acid intakes and coronary heart disease mortality in Japan: NIPPON DATA90, 1990-2005 Running title: Fatty acid intakes and coronary heart disease mortality
    Natural Products Journal - - --- in press  2012年 [無し][無し]
     研究論文(学術雑誌)
  • Akira Sekikawa, Takashi Kadowaki, Aiman El-Saed, Tomonori Okamura, Kim Sutton-Tyrrell, Yasuyuki Nakamura, Rhobert W. Evans, Ken-ichi Mitsunami, Daniel Edmundowicz, Yoshihiko Nishio, Katsumi Nakata, Aya Kadota, Teruo Otake, Katsuyuki Miura, Jina Choo, Robert D. Abbott, Lewis H. Kuller, J. David Curb, Hirotsugu Ueshima
    STROKE 42 9 2538 - U263 2011年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background and Purpose-Recent studies reported the differential effect of docosahexaenoic (DHA) and eicosapentaenoic acids (EPA). We examined the differential association of DHA and EPA with carotid intima-media thickness (IMT) in Japanese individuals in Japan and in U. S. white individuals and explored whether DHA or EPA contributes to the difference in IMT between the two groups. Methods-A population-based cross-sectional study in 608 Japanese and U. S. white men aged 40 to 49 was conducted to assess IMT, serum DHA, EPA, and other cardiovascular risk factors. Results-Japanese compared to U. S. whites had significantly lower IMT (mean +/- SD, 618 +/- 81 and 672 +/- 94 mu m for Japanese and whites, respectively; P<0.001) and had >2-fold higher levels of DHA and EPA. DHA, but not EPA, had an inverse association with IMT in both Japanese and U. S. whites. The inverse association remained only in Japanese men after adjusting for risk and other factors. The significant difference in multivariable-adjusted IMT became nonsignificant after further adjusting for DHA (mean difference, 17 mu m; 95% CI, -8 to 43; P=0.177) but not EPA. In this multivariable-adjusted model, DHA but not EPA was a significant predictor of IMT (P=-0.032 versus 0.863, respectively). Conclusions-These data suggest that DHA may have a more potent antiatherogenic effect than EPA, especially in levels observed in the Japanese, independent of risk factors. (Stroke. 2011;42:2538-2543.)
  • Nahid Rumana, Tanvir Chowdhury Turin, Katsuyuki Miura, Yasuyuki Nakamura, Yoshikuni Kita, Takehito Hayakawa, Sohel Reza Choudhury, Aya Kadota, Shin-Ya Nagasawa, Akira Fujioshi, Naoyuki Takashima, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima
    AMERICAN JOURNAL OF CARDIOLOGY 107 12 1718 - 1724 2011年06月 [有り][無し]
     研究論文(学術雑誌) 
    Little is known about the prognostic value of ST-segment depression and/or T wave (ST-T abnormalities) with or without left high R waves on electrocardiogram recorded at rest for death from cardiovascular disease (CVD) in Asian populations. Japanese participants without a history of CVD and free of major electrocardiographic (ECG) abnormalities were followed for 24 years. Subjects were divided into 4 groups based on baseline ECG findings: isolated left high R waves, isolated ST-T abnormalities, ST-T abnormalities with left high R waves, and normal electrocardiogram. Cox proportional hazard model was used to estimate risk of CVD mortality in groups with ECG abnormalities compared to the normal group. Of 8,572 participants (44.4% men, mean age 49.5 years; 55.6% women, mean age 49.4 years), 1,142 had isolated left high R waves, 292 had isolated ST-T abnormalities, and 128 had ST-T abnormalities with left high R waves at baseline. Multivariable-adjusted hazard ratios of ST-T abnormalities with left high R waves for CVD mortality were 1.95 (95% confidence interval 1.25 to 3.04) in men and 2.68 (95% confidence interval 1.81 to 3.97) in women. Isolated ST-T abnormalities increased the risk for CVD death by 1.66 times (95% confidence interval 1.01 to 2.71) in men and 1.62 times (95% confidence interval 1.18 to 2.24) in women. Association of ECG abnormalities with CVD mortality was independent of age, body mass index, systolic blood pressure, serum cholesterol, blood glucose, smoking and drinking, and antihypertensive medication. In conclusion, ST-T abnormalities with or without left high R waves on electrocardiogram recorded at rest constitute an independent predictor of CVD mortality in Japanese men and women. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:1718-1724)
  • Miyazawa I, Araki S, Obata T, Yoshizaki T, Morino K, Kadota A, Ugi S, Kawai H, Uzu T, Nishio Y, Koya D, Haneda M, Kashiwagi A, Maegawa H
    Diabetes research and clinical practice 92 2 174 - 180 2011年05月 [有り][無し]
     研究論文(学術雑誌) 
    Aim: The aim of our study was to investigate whether serum levels of soluble tumor necrosis factor alpha receptor (sTNFR) 1 and 2 are markers for renal dysfunction in type 2 diabetic patients without overt proteinuria. Methods: Japanese type 2 diabetic patients without overt proteinuria (n = 168) enrolled in the prospective observational follow-up study in 2001 were retrospectively analyzed. At baseline, the serum levels of sTNFR1 and sTNFR2 were measured by sandwich ELISA. The associations between these markers and change in estimated glomerular filtration rate (eGFR) after 5 years were evaluated. Results: The levels of sTNFR1 and sTNFR2 closely correlated. At baseline, sTNFR1 and sTNFR2 associated inversely with eGFR. After 5 years, patients with high level of both sTNFR1 and sTNFR2 showed a greater decline in eGFR (-13.8 +/- 15.5% versus -8.5 +/- 11.8%, P = 0.027) and a 4-fold higher risk for a GFR decline of >= 25% than those with high level of only one receptor or low level of both receptors. These associations were enhanced in diabetic women. Conclusions: The higher levels of sTNFR1 and sTNFR2 were associated with a greater decline in eGFR in type 2 diabetic patients without proteinuria, especially in diabetic women. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
  • 2型糖尿病患者の血小板活性化に対する日内血圧変動と高用量ARB投与の効果
    一色 啓二, 坂口 正芳, 門田 文, 横幕 由喜代, 久米 真二, 金崎 雅美, 荒木 信一, 杉本 俊郎, 前川 聡, 柏木 厚典, 宇津 貴
    糖尿病 54 3 200 - 200 (一社)日本糖尿病学会 2011年03月
  • 2010年国民健康栄養調査対象者の追跡開始(NIPPON DATA 2010)とNIPPON DATA80/90の追跡継続に関する研究
    三浦克之, 上島弘嗣, 和泉 徹, 大久保孝義, 岡村智教, 岡山 明, 奥田奈賀子, 尾島俊之, 笠置文善, 門田 文, 喜多義邦, 清原 裕, 斉藤重幸, 坂田清美, 中川秀昭, 中村保幸, 中村好一, 西 信雄, 早川岳人, 寶澤 篤, 松村康弘, 由田克士
    厚生労働科学研究費補助金(指定研究)循環器疾患・糖尿病等生活習慣病対策総合研究事業「2010年国民健康栄養調査対象者の追跡開始(NIPPON DATA2010)とNIPPON DATA80/90の追跡継続に関する研究」平成22年度総括・分担研究報告書 42012 2011年03月 [無し][無し]
     学位論文(その他)
  • 平成22年国民健康・栄養調査 実施自治体への協力依頼
    三浦克之, 門田 文, 大久保孝義, 岡村智教, 岡山 明, 和泉 徹, 尾島俊之, 笠置文善, 喜多義邦, 清原 裕, 斉藤重幸, 坂田清美, 中川秀昭, 中村保幸, 中村好一, 早川岳人, 寶澤 篤, 松村康弘, 由田克士
    厚生労働科学研究費補助金(指定研究)循環器疾患・糖尿病等生活習慣病対策総合研究事業「2010年国民健康栄養調査対象者の追跡開始(NIPPON DATA2010)とNIPPON DATA80/90の追跡継続に関する研究」平成22年度総括・分担研究報告書 19-30 2011年03月 [無し][無し]
     学位論文(その他)
  • Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Atsushi Hozawa, Yoshitaka Murakami, Akira Fujiyoshi, Naoyuki Takashima, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Yasuyuki Nakamura, Hirotsugu Ueshima
    ATHEROSCLEROSIS 215 1 209 - 213 2011年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: The individual components of metabolic syndrome are defined as levels ranging from moderate to high level as to require medication. We investigated the impact of moderate metabolic risk factor clustering on cardiovascular disease (CVD) mortality. Methods: We followed up 6758 non-lean Japanese in randomly selected areas from all over the country who had no history of CVD for 15 years. The multivariate-adjusted hazards ratio (HR) and 95% confidence interval (CI) for CVD mortality according to the number of moderate metabolic risk factors (BMI >= 25 kg/m(2), 130/85mmHg <= systolic/diastolic BP < 140/90mmHg, 140 mg/dl <= casual blood glucose < 200 mg/dl, triglycerides > 150 mg/dl and/or HDL cholesterol < 40 mg/dl [men], 50 mg/dl [women]) were estimated using the Cox proportional hazards model. The population-attributable risk fraction of moderate metabolic risk factor clustering was also estimated. Results: During the follow-up, 282 participants died of CVD. CVD mortality tended to increase with the number of moderate metabolic risk factors. However, they were not statistically significant. The multivariate-adjusted HRs were 1.82 (95% CI: 0.89-3.73) for having any moderate metabolic risk factors and 2.87 (95% CI: 1.46-5.64) for having any medication-required metabolic risk factors, compared with participants without any moderate metabolic risk factors. The population-attributable risk fractions were 7.3% and 52.4% for any moderate and medication-required metabolic risk factors, respectively. Conclusions: We did not find the statistically significant increase of CVD mortality for moderate metabolic risk factor clustering. Its attribution was relatively small in this Japanese population. More efforts would be required to detect and control medication-required risk factors. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
  • Robert D. Abbott, Aya Kadota, Katsuyuki Miura, Takehito Hayakawa, Takashi Kadowaki, Tomonori Okamura, Akira Okayama, Kamal H. Masaki, Hirotsugu Ueshima
    Journal of Aging Research 2011 324592  2011年 [有り][無し]
     研究論文(学術雑誌) 
    Introduction. Hypertension and cigarette smoking are dominant risk factors for cardiovascular disease in Japan while in westernized countries, broader effects encompass obesity, diabetes, and hypercholesterolemia. This paper examines whether different associations also appear important in the manifestation of activities of daily living (ADL) in older Japanese men in Hawaii and Japan. Methods. Measures of ADL (feeding, toileting, dressing, bathing, and walking around the house) were assessed from 1995 to 1999 in 1,893 men in Hawaii and 543 men in Japan. Concomitant risk factors were measured from 1990 to 1993. Results. In Hawaii, diabetes increased the odds of ≥1 ADL impairment nearly 1.5-fold (P=.020). A similar association was absent in Japan. In contrast, the odds of an ADL impairment in Japan was increased more than 5-fold in the presence of stroke (P< .001). The association in Hawaii was significantly weaker (P=.007). In both cohorts, past alcohol use was associated with a greater likelihood of ADL impairment. Conclusion. In this comparison of genetically similar samples, findings suggest that different strengths in risk factor associations with cardiovascular disease in Japan and westernized countries may also include different strengths in associations with impaired ADL. © 2011 Robert D. Abbott et al.
  • Kadota A, Miura K, Ueshima H
    Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 1 35 - 39 2011年01月 [有り][無し]
  • Katsumi Nakata, Jina Choo, Michael J. S. Hopson, Hirotsugu Ueshima, J. David Curb, Chol Shin, Rhobert W. Evans, Takashi Kadowaki, Teruo Otake, Aya Kadota, Syaka Kadowaki, Katsuyuki Miura, Aiman El-Saed, Daniel Edmundowicz, Kim Sutton-Tyrrell, Lewis H. Kuller, Akira Sekikawa
    METABOLISM-CLINICAL AND EXPERIMENTAL 59 12 1742 - 1751 2010年12月 [有り][無し]
     研究論文(学術雑誌) 
    Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index-adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index-adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men. (C) 2010 Elsevier Inc. All rights reserved.
  • Uzu T, Sakaguchi M, Tsuda A, Kadota A, Yokomaku Y, Kume S, Kanasaki M, Isshiki K, Araki S, Sugiomoto T, Maegawa H, Kashiwagi A
    Journal of diabetes investigation 1 5 196 - 201 2010年10月 [有り][無し]
     研究論文(学術雑誌) 
    Aims/Introduction: Platelet-derived microparticles (PDMP) are released from the platelets either after activation or in response to physical stimulation in vivo. The present study examined the association between blood pressure and PDMP, and the effects of high-dose angiotensin receptor blockers (ARB) on PDMP in patients with type 2 diabetes. Materials and Methods: The study subjects consisted of 28 type 2 diabetes patients with blood pressure ≥130/80 mmHg who were treated with valsartan (80 mg daily). The patients were randomly assigned to take either 80 mg of telmisartan (Tel group) or 160 mg of valsartan (Val group) and then were followed up for 24 weeks. Thereafter, the patients were switched to combination therapy (5 mg of amlodipine with 40 mg of telmisartan [Tel group] or 80 mg of valsartan [Val group]) for 12 weeks. Results: Although the ambulatory blood pressure did not change, the PDMP levels were significantly decreased from baseline to week 24 (high dose ARB). In contrast, combination therapy reduced both blood pressure and PDMP levels compared with the baseline. Although the PDMP level was significantly correlated with the morning BP elevation at baseline and week 36 (combination therapy), this same relationship was not found at week 24. There were no significant differences in the blood pressure and PDMP levels between the two groups. Conclusions: Patients with morning hypertension might be at risk for cardiovascular diseases. High-dose renin-angiotensin system inhibition and blood pressure control are both considered to reduce cardiovascular events in patients with type 2 diabetes. © 2010 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd.
  • Tanvir Chowdhury Turin, Yoshikuni Kita, Nahid Rumana, Naoyuki Takashima, Aya Kadota, Kenji Matsui, Hideki Sugihara, Yutaka Morita, Yasuyuki Nakamura, Katsuyuki Miura, Hirotsugu Ueshima
    HYPERTENSION RESEARCH 33 9 922 - 925 2010年09月 [有り][無し]
     研究論文(学術雑誌) 
    Brachial-ankle pulse wave velocity (baPWV) is a relatively new non-invasive measure of arterial stiffness obtained using an automated system. We assessed the relationship between baPWV and 6.5-year overall mortality from the Takashima cohort study. The baPWV was measured in 2642 participants at baseline. When participants were divided into tertiles, all-cause mortality increased significantly as baPWV increased (P<0.001). Participants in the highest baPWV tertile showed an increased risk of all-cause mortality evidenced by a multivariable adjusted hazard ratio of 6.8 (95% confidence interval: 1.4-32.8) as compared with the lowest tertile. The present study demonstrated that increased baPWV is an independent predictor of all-cause mortality in the Japanese population. Hypertension Research (2010) 33, 922-925; doi: 10.1038/hr.2010.103; published online 17 June 2010
  • Ryoko W. Azuma, Takashi Kadowaki, Aiman El-Saed, Hirotsugu Ueshima, Kim Sutton-Tyrrell, Yasuyuki Nakamura, Daniel Edmundowicz, Yoshiki Ueno, Rhobert W. Evans, Aya Kadota, Lewis H. Kuller, Kiyoshi Murata, Tomoko Takamiya, Sayaka Kadowaki, J. David Curb, Akira Sekikawa
    ACTA CARDIOLOGICA 65 4 449 - 456 2010年08月 [有り][無し]
     研究論文(学術雑誌) 
    Objective - D-dimer and von Willebrand factor (vWF) are associated with atherosclerosis. We recently reported that in a post-World War II birth cohort, Japanese men in Japan had lower levels of atherosclerosis than white men in the United States (US). We examined whether the differences in D-dimer and vWF levels are associated with differences in atherosclerosis between the two populations. Methods and results - Population-based samples of 99 Japanese and 100 white American men aged 40-49 years were examined for coronary artery calcification (CAC), carotid intima-media thickness (IMT), D-dimer, vVVF, and other factors using a standardized protocol. When compared to white American men, Japanese had similar levels of D-dimer (0.22 +/- 0.28 vs. 0.19 +/- 0.24 mu g/L, respectively, P = 0.39) but significantly higher levels of vWF (124.1 +/- 36.6 vs. 91.3 +/- 48.8%, respectively, P < 0.01). Japanese as compared to white American men had significantly lower prevalence of CAC (13.1 vs. 28.0%, P < 0.01, respectively) and significantly lower IMT (0.61 +/- 0.07 vs. 0.66 +/- 0.08 mm, P < 0.01, respectively). Japanese men had a significant positive association of D-dimer with the prevalence of CAC and a negative association of vVVF with IMT, whereas white American men did not have any significant associations. Conclusions - In men aged 40-49 years, Japanese as compared to white Americans had similar levels of D-dimer and higher levels of vVVF although Japanese had a significantly lower prevalence of CAC and IMT. These haemostatic factors are unlikely to explain the difference in atherosclerosis in these populations.
  • Akira Sekikawa, Takashi Kadowaki, J. David Curb, Rhobert W. Evans, Hiroshi Maegawa, Robert D. Abbott, Kim Sutton-Tyrrell, Tomonori Okamura, Chol Shin, Daniel Edmundowicz, Aya Kadota, Jina Choo, Aiman El-Saed, Hirotsugu Ueshima, Lewis H. Kuller
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 30 7 541 - 548 2010年07月 [有り][無し]
     研究論文(学術雑誌) 
    This study examines the differences in circulating levels of cytokines among Japanese in Japan (JJ), Japanese Americans (JA), and whites and their associations with obesity and marine n-3 fatty acids (FA) in a cross-sectional population-based study of 297 men aged 40-49 (100 JJ, 99 whites, and 98 JA). Experimental studies show that cytokines are associated with obesity positively and marine n-3 FA inversely. Serum interleukin-1 alpha (IL-1 alpha), IL-1 receptor agonist (IL-1ra), IL-4, IL-8, IL-10, inducible protein-10 (IP-10), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and marine n-3 FA were determined. Body mass index (BMI), waist circumference, and computed tomography-measured visceral and subcutaneous adipose tissues were determined. The JJ had significantly lower levels of IL-1 alpha, IL-4, IL-8, MCP-1, and TNF-alpha than whites and JA. Whites and JA had similar levels of IL-1 alpha, IL-4, and IL-8 whereas whites had significantly higher levels of MCP-1 and TNF-alpha than JA. The JJ were least obese (BMI (kg/m(2)), mean +/- standard deviation) 23.6 +/- 2.8, 27.9 +/- 4.6, and 27.9 +/- 4.5 for JJ, whites, and JA, respectively. The JJ had marine n-3 FA about 100% higher than whites and JA (serum marine n-3 FA (%), median (interquartile range) 8.79 (7.41, 11.16), 3.47 (2.63, 4.83), and 4.44 (3.33, 6.01) for JJ, whites, and JA, respectively). Generally cytokines had weak and nonsignificant associations with indices of obesity and nonsignificant associations with marine n-3 FA. BMI had significant inverse associations with IL-1 alpha, IL-4, and IL-8 in JA (P < 0.05). Marine n-3 FA had marginally significant inverse associations with IL-8 in JJ (P = 0.055) and TNF-alpha in whites (P = 0.076). The JJ had lower levels of many cytokines than whites and JA. Generally cytokines had weak and nonsignificant associations with indices of obesity and marine n-3 FA. Further investigation is needed to determine why JJ had lower circulating levels of cytokines.
  • Kadota A, Miura K, Ueshima H
    Nihon rinsho. Japanese journal of clinical medicine 68 5 847 - 852 2010年05月 [有り][無し]
  • 2型糖尿病患者における血清可溶性受容体マーカーと糖尿病合併症との関連
    宮澤 伊都子, 小畑 利之, 吉崎 健, 門田 文, 卯木 智, 荒木 信一, 西尾 善彦, 村上 義孝, 柏木 厚典, 前川 聡
    糖尿病 53 Suppl.1 S - 178 (一社)日本糖尿病学会 2010年04月
  • Tanvir Chowdhury Turin, Nagako Okuda, Katsuyuki Mura, Yasuyuki Nakamura, Nahid Rumana, Aya Kadota, Koji Tamakoshi, Hirotsugu Ueshima
    JOURNAL OF EPIDEMIOLOGY 20 S557 - S566 2010年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: The purpose of this study was to investigate the dietary iron intake and associated other dietary factors and clinical characteristics among a representative sample cohort of Japanese population. Methods: We obtained data from NIPPON DATA80 and 90 that were conducted with the National Nutrition Surveys in 1980 and in 1990. Then we estimated nutrient and food intakes of individuals in the National Nutrition Survey of 1980 and that of 1990, which were adjusted on the basis of data of the National Nutrition Survey of 1995. Finally, we analyzed data for the 10 422 participants (4585 men and 5837 women) in NIPPON DATA80 and 8342 participants (3488 men and 4854 women) in NIPPON DATA90 having dietary iron intake information. Results: In NIPPON DATA80 and 90, there was a significant relationship between the dietary iron intake and age for both men and women. Dietary protein intake was associated with iron intake where as dietary fat intake did not show any association. Regarding the minerals, significant relationships were observed between the different minerals and dietary iron intake. Apart from the food group of milk and dairy products, there were significant differences in other food groups according to quintiles of iron intakes for men and women. Conclusions: We described the mean dietary iron intake and its relation with other dietary factors and clinical characteristics in Japanese adults as the baseline data in NIPPON DATA80 and in NIPPON DATA90.
  • Akiko Morimoto, Naomi Miyamatsu, Tomonori Okamura, Atsushi Hozawa, Aya Kadota, Miho Morinaga, Mihoko Ogita, Atsunori Kashiwagi, Hirotsugu Ueshima
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 17 4 361 - 368 2010年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: The relationship between psychosocial characteristics and smoking cessation behavior was examined among Japanese male ever-smokers with type 2 diabetes mellitus. Methods: The psychosocial characteristics and smoking cessation behavior of 441 male ever-smokers with type 2 diabetes mellitus were investigated. Personality was assessed using an egogram (five ego states: the Critical Parent, Nurturing Parent, Adult, Free Child, and Adapted Child) and each patient was classified into a high score or low score group based on the median. The current smokers were divided into 2 categories according to their readiness to quit smoking. Results: In multivariate analyses, the ever-smokers with a high Adult score had a lower risk of current smoking (OR = 0.67, 95%CI = 0.41-0.93), the ever-smokers with a high Free Child score were over 3 times more likely to currently smoke (OR = 3.12, 95%CI = 1.97-4.97), and the ever-smokers who had a low educational background had a higher risk of current smoking (OR = 3.02, 95%CI = 1.73-5.28). In addition, the current smokers with a high Adult score had a lower risk of being in the immotive and precontemplation stage (OR = 0.55, 95%CI = 0.24-0.96). The current smokers who had a low educational background had a higher risk of being in the immotive and precontemplation stage (OR = 2.13, 95%CI = 1.08-5.42). Conclusion: There is a need to develop a smoking cessation program for patients with high "Free Child" scores and a "low education level".
  • Naoyuki Takashima, Katsuyuki Miura, Atsushi Hozawa, Aya Kadota, Tomonori Okamura, Yasuyuki Nakamura, Takehito Hayakawa, Nagako Okuda, Akira Fujiyoshi, Shin-Ya Nagasawa, Takashi Kadowaki, Yoshitaka Murakami, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima
    BMC Public Health 10 306  2010年 [有り][無し]
     研究論文(学術雑誌) 
    Background. Smoking and metabolic syndrome are known to be related to cardiovascular diseases (CVD) risk. In Asian countries, prevalence of obesity has increased and smoking rate in men is still high. We investigated the attribution of the combination of smoking and metabolic syndrome (or obesity) to excess CVD deaths in Japan. Methods. A cohort of nationwide representative Japanese samples, a total of 6650 men and women aged 30-70 at baseline without history of CVD was followed for 15 years. Multivariate-adjusted hazard ratio for CVD death according to the combination of smoking status and metabolic syndrome (or obesity) was calculated using Cox proportional hazard model. Population attributable fraction (PAF) of CVD deaths was calculated using the hazard ratios. Results. During the follow-up period, 87 men and 61 women died due to CVD. The PAF component of CVD deaths in non-obese smokers was 36.8% in men and 11.3% in women, which were higher than those in obese smokers (9.1% in men and 5.2% in women). The PAF component of CVD deaths in smokers without metabolic syndrome was 40.9% in men and 11.9% in women, which were also higher than those in smokers with metabolic syndrome (7.1% in men and 3.9% in women). Conclusion. Our results indicated that a large proportion of excess CVD deaths was observed in smokers without metabolic syndrome or obesity, especially in men. These findings suggest that intervention targeting on smokers, irrespective of the presence of metabolic syndrome, is still important for the prevention of CVD in Asian countries. © 2010 Takashima et al licensee BioMed Central Ltd.
  • NIPPON DATAにおける糖尿病と心血管病
    日本臨床 68 5 847 - 851 2010年 [無し][無し]
     研究論文(学術雑誌)
  • NIPPON DATAにおける糖尿病と心血管病
    日本臨床 68 5 847 - 851 2010年 [無し][無し]
     研究論文(学術雑誌)
  • Yasuyuki Nakamura, Hirotsugu Ueshima, Aya Kadota, Atsushi Hozawa, Tomonori Okamura, Sayaka Kadowaki, Takashi Kadowaki, Takehito Hayakawa, Yoshikuni Kita, Robert D. Abbott, Akira Okayama
    ALCOHOL 43 8 635 - 641 2009年12月 [有り][無し]
     研究論文(学術雑誌) 
    Although moderate alcohol intake in diabetic Caucasians is associated with a reduction in coronary heart disease mortality, no study in Japanese with diabetes has examined the association between alcohol intake and mortality outcomes. We analyzed the relationship between alcohol intake and all-cause and cause-specific mortality using the database from NIPPON DATA80. At the baseline in 1980, data on history, lifestyle, and physical examinations were collected on study participants aged 30 years and older from randomly selected areas in Japan. After excluding participants with comorbidities, we followed 4,018 male participants (3,614 nondiabetics, 195 with impaired glucose tolerance and 209 diabetic) for 19 years. During the 19 years of follow-up, there were 990 deaths; 328 were from cardiovascular disease and 157 from all-heart diseases. With the never-drinking category serving as a reference, the Cox multivariate-adjusted hazard ratios for non-daily and daily drinkers for cardiovascular mortality were 0.43 (95% confidence intervals: 0.19-0.95) and 0.45 (0.25-0.80), respectively, and 0.33 (0.12-0.91) and 0.31 (0.15-0.67) for all-heart disease mortality in the combined impaired glucose tolerance and diabetic Japanese men. Alcohol drinking in men with glucose intolerance was associated with a significant reduction in cardiovascular and all-heart disease mortality as seen in the general population in Japan. (C) 2009 Elsevier Inc. All rights reserved.
  • Koichiro Azuma, Takashi Kadowaki, Cemal Cetinel, Aya Kadota, Aiman El-Saed, Sayaka Kadowaki, Daniel Edmundowicz, Yoshihiko Nishio, Kim Sutton-Tyrrell, Tomonori Okamura, Rhobert W. Evans, Tomoko Takamiya, Hirotsugu Ueshima, J. David Curb, Robert D. Abbott, Lewis H. Kuller, David E. Kelley, Akira Sekikawa
    METABOLISM-CLINICAL AND EXPERIMENTAL 58 8 1200 - 1207 2009年08月 [有り][無し]
     研究論文(学術雑誌) 
    Among Asians, including Japanese, obesity is related to dyslipidemia and insulin resistance at a lower level of body mass index (BMI) compared with non-Hispanic whites (NHW). We hypothesize that this ethnic difference in the relationship between BMI and metabolic risks is partly associated with the ethnic difference in fat distribution, namely, liver fat as well as visceral adipose tissue. To compare liver fat content among Japanese vs NHW men, regional computed tomographic images were taken to measure liver computed tomographic density in population-based samples of 3 13 Japanese and 288 NHW men aged 40 to 49 years, along with the assessment of metabolic parameters. Liver fat content was higher in Japanese than NHW men (liver to spleen attenuation ratio [lower value means higher liver fat content]: 1.01 +/- 0.16 vs 1.07 +/- 0.15, respectively; P<.01), despite a lower mean BMI in Japanese men (BMI: 23.6 +/- 2.9 vs 27.8 +/- 4.2 kg/m(2) p<.01). Moreover, Japanese men had a greater disposition for fatty liver with a small increase in BMI than NHW (P<.01), whereas both groups had a similar relationship between visceral adipose tissue and BMI. In both groups, liver fat content correlated with triglycerides, homeostasis model assessment Of insulin resistance, and C-reactive protein. Liver fat content is higher among Japanese than NHW; and this ethnic difference becomes more robust with a small increase in BMI, suggesting that fatty liver is a sensitive marker for the failure of the adipose tissue to expand to accommodate an increased energy influx, and is associated with similar metabolic risk in Japanese despite lower BMI compared with NHW men. (C) 2009 Elsevier Inc. All rights reserved.
  • Kenneth R. Motoyama, J. David Curb, Takashi Kadowaki, Aiman El-Saed, Robert D. Abbott, Tomonori Okamura, Rhobert W. Evans, Yasuyuki Nakamura, Kim Sutton-Tyrrell, Beatriz L. Rodriquez, Aya Kadota, Daniel Edmundowicz, Bradley J. Willcox, Jina Choo, Nakata Katsumi, Teruo Otake, Sayaka Kadowaki, Lewis H. Kuller, Hirotusgu Ueshima, Akira Sekikawa
    AMERICAN JOURNAL OF CLINICAL NUTRITION 90 1 49 - 55 2009年07月 [有り][無し]
     研究論文(学術雑誌) 
    Background: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known. Objective: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40 49 y. Design: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used. Results: Serum n-6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [beta = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [beta = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (beta = 4.49, P < 0.001) and Japanese (beta = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P < 0.01). Conclusion: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations. Am J Clin Nutr 2009;90:49-55.
  • Yasuyuki Nakamura, Akira Sekikawa, Takashi Kadowaki, Aya Kadota, Sayaka Kadowaki, Hiroshi Maegawa, Yoshikuni Kita, Rhobert W. Evans, Daniel Edmundowicz, J. David Curb, Hirotsugu Ueshima
    OBESITY 17 6 1269 - 1273 2009年06月 [有り][無し]
     研究論文(学術雑誌) 
    Adiponectin is reduced in obesity and has been suggested to play an important role in modulation of atherosclerosis. We studied the relationship between visceral (VAT) and subcutaneous (SAT) adipose tissue and serum adiponectin concentrations in Japanese men. Participants were 304 randomly selected community-based Japanese men aged 40-49 without a prior history of cardiovascular disease. Participants were grouped according to tertiles of serum adiponectin. In multiple linear regression analysis including age, pack years of smoking, and alcohol intake as covariates, log-transformed adiponectin was inversely associated with both VAT and SAT when these two obesity measures were included separately in the models. However, log-transformed adiponectin was inversely associated with VAT (standardized beta estimate = -0.465; P < 0.0001) and positively associated with SAT (standardized beta estimate = 1.277; P = 0.03), when these were included concomitantly in the model. In conclusion, VAT and SAT had differential associations with serum adiponectin concentrations.
  • 奥田 奈賀子, 岡村 智教, 門田 文, 村上 義孝, 宮松 直美, 田中 太一郎, 盛永 美保, 柳田 昌彦, 月野木 ルミ, 田中 信子, 高田 桂子, 船越 傳, 上島 弘嗣
    日本循環器病予防学会誌 = Japanese journal of cardiovascular disease prevention 44 1 10 - 21 2009年 [無し][無し]
     研究論文(学術雑誌)
  • 内臓脂肪減少を目的とした軽負担の保健指導が男性工場従業員の食習慣に及ぼす変化
    日循予防誌 44,10-21 2009年 [無し][無し]
     研究論文(学術雑誌)
  • Hirotsugu Ueshima, Akira Sekikawa, Katsuyuki Miura, Tanvir Chowdhury Turin, Naoyuki Takashima, Yoshikuni Kita, Makoto Watanabe, Aya Kadota, Nagako Okuda, Takashi Kadowaki, Yasuyuki Nakamura, Tomonori Okamura
    CIRCULATION 118 25 2702 - 2709 2008年12月 [有り][無し]
  • Aya Kadota, Tomonori Okamura, Atsushi Hozawa, Takashi Kadowaki, Yoshitaka Murakami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Yasuyuki Nakamura, Hirotsugu Ueshima
    HYPERTENSION RESEARCH 31 8 1525 - 1531 2008年08月 [有り][無し]
     研究論文(学術雑誌) 
    A family history of stroke seems to be related with increased risk of stroke although the relationship is not always significant. Increased risk of stroke is strongly associated with hypertension, which might be also associated with family history. However, investigations into the relationship between family history of hypertension and stroke mortality are scarce. We investigated whether a family history of stroke and that of hypertension evaluated using a simple questionnaire could predict stroke mortality in Japanese. We obtained parental histories of stroke and of hypertension from 8,037 randomly selected general Japanese without history of cardiovascular disease and followed them for 19 years. The multivariate adjusted hazard ratios (HRs) for total stroke mortality, intra-cerebral hemorrhage mortality and for cerebral infarction mortality according to family history were estimated using the Cox proportional hazards model. The prevalences of family histories of stroke and of hypertension were 20.6% and 31.1%, respectively. A family history of stroke was not related to total stroke mortality, intra-cerebral hemorrhage mortality or to cerebral infarction mortality. Meanwhile, a family history of hypertension was positively related to total stroke mortality among women aged less than 60 years and men aged 60 or more years (women: HR=3.41, 95% confidence interval [CI]: 1.49-7.81; men: HR =1.50, 95% CI: 1.00-2.24) even after adjustment for systolic blood pressure. In conclusion, a family history of stroke could not predict total stroke mortality. However, a family history of hypertension might predict an increased risk for total stroke. (Hypertens Res 2008; 31: 1525-1531)
  • S. Kadowaki, T. Okamura, A. Hozawa, T. Kadowaki, A. Kadota, Y. Murakami, K. Nakamura, S. Saitoh, Y. Nakamura, T. Hayakawa, Y. Kita, A. Okayama, H. Ueshima
    DIABETOLOGIA 51 4 575 - 582 2008年04月 [無し][無し]
     研究論文(学術雑誌) 
    Aims/hypothesis High fasting blood glucose is one of the well-known risk factors for CHD. However, in certain settings, patients cannot always be expected to fast. For example, community screenings for cardiovascular disease (CVD) risk factors in Japan are performed under non-fasting conditions to achieve high participation rates. Thus, we examined a representative cohort of the Japanese population (n = 9,444, follow-up period 17.3 years) to clarify whether high casual blood glucose (CBG) can predict CVD mortality. Methods We defined CBG groups as follows: high CBG >= 11.1 mmol/l or participants with a history of diabetes mellitus; borderline high, 7.77 <= CBG < 11.1 mmol/l; higher normal, 5.22 <= CBG < 7.77 mmol/l); and lower normal, CBG < 5.22 mmol/l. The multivariate-adjusted hazard ratios (HRs) for CHD, CVD and all-cause mortality were calculated. Results The crude CHD mortality rate was 0.84 per 1,000 person-years. Age- and sex-adjusted HRs for CHD mortality were high among participants with CBG levels >= 7.77 mmol/l, regardless of time since last meal. Multivariate-adjusted HRs (95% CI) of CHD mortality in high and borderline high CBG groups were 2.62 (1.46-4.67) and 2.43 (1.29-4.58), respectively. Similar results were observed for both CVD and all-cause mortality. Even within the normal blood glucose range, each 1 mmol/l increase in CBG was associated with a statistically significant increase in the HR for CVD mortality (1.12, 95% CI 1.02-1.22). Population-attributable fractions of the combined groups of high and borderline high CBG for CHD, CVD and all-cause mortality were 12.0, 4.9 and 3.5%, respectively. Conclusions/Interpretation Increases in CBG, even within the normal range, predict CVD mortality.
  • S. Kadowaki, T. Okamura, A. Hozawa, T. Kadowaki, A. Kadota, Y. Murakami, K. Nakamura, S. Saitoh, Y. Nakamura, T. Hayakawa, Y. Kita, A. Okayama, H. Ueshima
    DIABETOLOGIA 51 4 575 - 582 2008年04月 [無し][無し]
     研究論文(学術雑誌) 
    Aims/hypothesis High fasting blood glucose is one of the well-known risk factors for CHD. However, in certain settings, patients cannot always be expected to fast. For example, community screenings for cardiovascular disease (CVD) risk factors in Japan are performed under non-fasting conditions to achieve high participation rates. Thus, we examined a representative cohort of the Japanese population (n = 9,444, follow-up period 17.3 years) to clarify whether high casual blood glucose (CBG) can predict CVD mortality. Methods We defined CBG groups as follows: high CBG >= 11.1 mmol/l or participants with a history of diabetes mellitus; borderline high, 7.77 <= CBG < 11.1 mmol/l; higher normal, 5.22 <= CBG < 7.77 mmol/l); and lower normal, CBG < 5.22 mmol/l. The multivariate-adjusted hazard ratios (HRs) for CHD, CVD and all-cause mortality were calculated. Results The crude CHD mortality rate was 0.84 per 1,000 person-years. Age- and sex-adjusted HRs for CHD mortality were high among participants with CBG levels >= 7.77 mmol/l, regardless of time since last meal. Multivariate-adjusted HRs (95% CI) of CHD mortality in high and borderline high CBG groups were 2.62 (1.46-4.67) and 2.43 (1.29-4.58), respectively. Similar results were observed for both CVD and all-cause mortality. Even within the normal blood glucose range, each 1 mmol/l increase in CBG was associated with a statistically significant increase in the HR for CVD mortality (1.12, 95% CI 1.02-1.22). Population-attributable fractions of the combined groups of high and borderline high CBG for CHD, CVD and all-cause mortality were 12.0, 4.9 and 3.5%, respectively. Conclusions/Interpretation Increases in CBG, even within the normal range, predict CVD mortality.
  • Nakamura Yasuyuki, Ueshima Hirotsugu, Kadota Aya, Hozawa Atsushi, Okamura Tomonori, Kadowaki Sayaka, Kadowaki Takashi, Hayakawa Takehito, Kita Yoshikuni, Abbott Robert D, Okayama Akira
    CIRCULATION 117 11 2008年03月 [有り][無し]
  • Aya Kadota, Atsushi Hozawa, Tomonori Okamura, Takashi Kadowak, Koshi Nakmaura, Yoshitaka Murakami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Yasuyuki Nakamura, Atsunori Kashiwagi, Hirotsugu Ueshima
    DIABETES CARE 30 6 1533 - 1538 2007年06月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVE - Metabolic syndrome is diagnosed according to several criteria. Of these, some require glucose intolerance and others require obesity for the diagnosis. We investigated the relationship between metabolic risk factor clustering and cardiovascular disease (CVD) mortality stratified by high blood glucose or obesity. RESEARCH DESIGN AND METHODS - We followed 7,219 Japanese men and women without a history of CVD for 9.6 years. We defined high blood pressure, high blood glucose, high triglycerides. low HDL cholesterol, and obesity as metabolic factors. The multivariate adjusted hazard ratio (HR) for CVD mortality according to the number of clustering metabolic factors was calculated using the Cox proportional hazards model. RESULTS - During follow-up, 173 participants died of CVD. The numbers of metabolic risk factors and CVD mortality were positively correlated (P-trend = 0.07). The HR was obviously higher among participants With than among those without high blood glucose and clustering of >= 2 other metabolic risk factors (HR 3.67 [95% CI 1.49-9.03]). However, the risk increase was only modest in participants without high blood glucose even if they had; >= 2 other metabolic risk factors (1.99 [0.93-4.28]). Conversely, metabolic risk factor clustering was related to CVD mortality irrespective of obesity. CONCLUSIONS - Our findings suggest that glucose tolerance plays an important role in CVD mortality. Because the prevalence of nonobese participants with several metabolic risk factors was quite high and their CVD risk was high, excluding them from the diagnosis of metabolic syndrome because of the absence of obesity might overlook their risk.
  • 糖尿病患者動脈硬化症評価におけるメタボリック症候群新診断基準の意義について
    門田 文, 前川 聡, 門脇 崇, 近藤 慶子, 西尾 喜彦, 岡村 智教, 上島 弘嗣, 柏木 厚典
    糖尿病 49 6 498 - 498 (一社)日本糖尿病学会 2006年06月
  • Aya Kadota-Shinozaki, Taka-Aki Nakamura, Hideki Hidaka, Hideto Kojima, Hitoshi Yasuda, Atsunori Kashiwagi, Ryuichi Kikkawa
    Internal Medicine 36 8 571 - 574 1997年 [無し][無し]
     研究論文(学術雑誌) 
    A 19-year-old woman with diabetic lipemia and maturity-onset diabetes of the young (MODY) is reported. Though her insulin secretory activity was preserved, she fell into mild diabetic ketoacidosis (DKA) and showed type V hyperlipidemia. Post-heparin plasma activity of lipoprotein lipase (LPL) was decreased even 10 days after initiating insulin injection but not deficient. The abnormalities in lipid metabolism were improved by long-term insulin treatment. Though the contribution of the genetic background to the lipid abnormalities is not clear, the characteristics of MODY in this patient including insulin secretory capacity under stress conditions such as DKA might play a role in the development of diabetic lipemia.
  • Aya Kadota-Shinozaki, Taka-Aki Nakamura, Hideki Hidaka, Hideto Kojima, Hitoshi Yasuda, Atsunori Kashiwagi, Ryuichi Kikkawa
    Internal Medicine 36 8 571 - 574 1997年 [無し][無し]
     研究論文(学術雑誌) 
    A 19-year-old woman with diabetic lipemia and maturity-onset diabetes of the young (MODY) is reported. Though her insulin secretory activity was preserved, she fell into mild diabetic ketoacidosis (DKA) and showed type V hyperlipidemia. Post-heparin plasma activity of lipoprotein lipase (LPL) was decreased even 10 days after initiating insulin injection but not deficient. The abnormalities in lipid metabolism were improved by long-term insulin treatment. Though the contribution of the genetic background to the lipid abnormalities is not clear, the characteristics of MODY in this patient including insulin secretory capacity under stress conditions such as DKA might play a role in the development of diabetic lipemia.

書籍

  • 最新臨床脳卒中学(第2版)上
    (範囲:Ⅱ疫学3NIPPON DATA 最近の知見)
    日本臨牀社 2022年01月
  • 尾島, 俊之, 堤, 明純 (範囲:6章 生活習慣(ライフスタイル)の現状と対策)
    南江堂 2020年03月 ISBN: 9784524248629 ix, 215p
  • 糖尿病と循環器病一歩進んだ糖尿病循環器学
    (範囲:第1章糖尿病と循環器病の疫学 (1)循環器分野の立場から.)
    医薬ジャーナル社 2017年
  • 肥満症診療ガイドライン2016. 日本肥満学会(編)
    (範囲:第3章肥満、肥満症の疫学(2)肥満の健康障害への影響.)
    ライフサイエンス出版 2016年
  • コメデイカルのための専門基礎分野テキスト公衆衛生学第3版. 柳川洋(編).
    (範囲:学校保健.)
    中外医学社 2014年
  • 健康教育マニュアル
    飯島 美世子, 上島 弘嗣, 岡村 智教, 奥田 奈賀子, 栗林 徹, 東山 綾, 三浦 克之, 渡邊 至, 門田 文, 久松 隆史, 田中 太一郎, 中村 幸志, 宮本 恵宏, 久保田 芳美, 杉山 大典 (範囲:生活習慣病の治療薬3.脂質異常症)
    一般社団法人 日本家族計画協会 2014年 
    Volume:/Number:/StartingPage:/EndingPage:
  • メタボリックシンドローム 基礎・臨床の最新知見
    (範囲:国民健康栄養調査、健康日本21から見た我が国におけるメタボリックシンドロームの趨勢.)
    日本臨床社 2011年
  • NIPPON DATAからみた循環器疾患のエビデンス. 上島弘嗣(編)
    (範囲:NIPPON DATAからみた循環器疾患の危険因子 メタボリックシンドローム危険因子の重積と循環器疾患NIPPON DATA90.)
    日本医事新報社 2008年
  • 新時代の糖尿病学(3) 病因・診断・治療研究の進歩.
    (範囲:糖尿病治療学の進歩 食事療法 アルコール摂取のあり方.)
    日本臨床社 2008年
  • 糖尿病学2008.
    (範囲:リスク集積と循環器疾患死亡NIPPON DATA90.)
    診断と治療社 2008年
  • PWVを知る、PWVで診る
    (範囲:PWVに影響しうる要因とその機序-炎症.)
    中山書店 2006年

講演・口頭発表等

  • 月野木ルミ, 村上義孝, 三浦克之, 三浦克之, 岡村智教, 門田文, 門田文, 早川岳人, 岡山明, 上島弘嗣, 上島弘嗣
    日本公衆衛生学会総会抄録集 2018年10月
  • 梅本かおり, 梅本かおり, 東山綾, 東山綾, 平田匠, 平田匠, 杉山大典, 杉山大典, 桑原和代, 桑原和代, 平田あや, 平田あや, 西田陽子, 久保佐智美, 久保田芳美, 久保田芳美, 門田文, 門田文, 西川智文, 西川智文, 宮松直美, 宮松直美, 宮本恵宏, 宮本恵宏, 岡村智教, 岡村智教
    日本公衆衛生学会総会抄録集 2018年10月
  • 大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本公衆衛生学会総会抄録集 2018年10月
  • 高血圧の有無による植物性タンパク質摂取量と循環器死亡の関連 NIPPONDATA90
    栗原 綾子, 岡村 智教, 東山 綾, 渡邉 至, 奥田 奈賀子, 由田 克士, 大久保 孝義, 岡山 明, 宮川 尚子, 門田 文, 藤吉 朗, 三浦 克之, 上島 弘嗣
    日本高血圧学会総会プログラム・抄録集 2018年09月
  • 日本人男性一般集団における野菜の摂取頻度と認知機能低下 SESSA研究
    宮川 尚子, 大久保 孝義, 藤吉 朗, 斎藤 祥乃, 久松 隆史, 門田 文, 関川 暁, 三浦 克之, 上島 弘嗣
    日本老年医学会雑誌 2018年05月
  • 地域住民一般男性における筋肉面積、脂肪筋面積と年齢や体格との関連の検討 SESSA/ERA-JUMP横断研究
    藤吉 朗, 門脇 紗也佳, 東 宏一郎, 門田 文, 近藤 慶子, 久松 隆史, 国村 彩子, 関川 暁, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 2018年05月
  • 家族構成と循環器疾患、心不全と総死亡との関連 NIPPON DATA90
    鈴木 春満, 門田 文, 奥田 奈賀子, 佐藤 敦, 西 信雄, 大久保 孝義, 高嶋 直敬, 三浦 克之, 岡山 明, 岡村 智教, 上島 弘嗣, the NIPPON DATA, Research group
    日本循環器病予防学会誌 2018年05月
  • 日本人一般住民男性における腸内細菌と血清LDLコレステロールとの関連 SESSA研究
    岡見 雪子, 有馬 久富, 近藤 慶子, 安藤 朗, 藤吉 朗, 門田 文, 久松 隆史, 宮澤 伊都子, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 2018年05月
  • CTによる肝脾CT値比と糖尿病発症リスクとの関連 滋賀動脈硬化疫学研究
    布施 恵子, 門田 文, 近藤 慶子, 藤吉 朗, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 森野 勝太郎, 関根 理, 卯木 智, 前川 聡, 三浦 克之, 上島 弘嗣, SESSA研究グループ
    糖尿病 2018年04月
  • 日本人一般住民男性における腸内細菌と糖尿病有病との関連
    近藤 慶子, 有馬 久富, 岡見 雪子, 安藤 朗, 藤吉 朗, 門田 文, 久松 隆史, 宮澤 伊都子, 森野 勝太郎, 前川 聡, 三浦 克之, 上島 弘嗣, 滋賀動脈硬化疫学研究, SESSA)グループ
    糖尿病 2018年04月
  • 赤身・加工肉摂取と心血管疾患死亡との関連は腎機能により異なるか? NIPPON DATA80
    瀬川 裕佳, 近藤 慶子, 山内 宏美, 大野 聖子, 田中 佐智子, 門田 文, 岡村 智教, 三浦 克之, 岡山 明, 上島 弘嗣, NIPPON DATA, 研究グループ
    日本腎臓学会誌 2018年04月
  • 日本人一般集団における血清N-3 polyunsaturated fatty acidと高感度C反応性蛋白の関連性(Association of Serum N-3 Polyunsaturated Fatty Acids and High-sensitivity C-reactive Protein in Japanese General Population)
    中村 翼, 門田 文, 近藤 慶子, 宮川 尚子, 関川 暁, 藤 吉朗, 久松 隆史, 三浦 克之, 上島 弘嗣
    日本循環器学会学術集会抄録集 2018年03月
  • 日本人男性の一般集団における腸内微生物叢と冠動脈石灰化 Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)(Gut Microbiota and Coronary Artery Calcification in a General Population of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA))
    有馬 久富, 近藤 慶子, 岡見 雪子, 藤 吉朗, 門田 文, 高嶋 直敬, 久松 隆史, 門脇 紗也佳, 宮澤 伊都子, 三浦 克之, 上島 弘嗣
    日本循環器学会学術集会抄録集 2018年03月
  • 一般集団における家計支出とBMIに関連した食事摂取量に関する横断的分析 NIPPON DATA 2010(A Cross-sectional Analysis of Dietary Intake in Relation to Household Expenditures and BMI in a General Population: NIPPON DATA 2010)
    菅原 悠, 近藤 慶子, 田中 佐智子, 門田 文, 中村 保幸, 奥田 奈賀子, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器学会学術集会抄録集 2018年03月
  • YANG Yunqing, HOZAWA Atsushi, KOGURE Mana, NARITA Akira, NAKAMURA Tomohiro, TSUCHIYA Naho, NAKAYA Naoki, NINOMIYA Toshiharu, OKUDA Nagako, KADOTA Aya, OHKUBO Takayoshi, OKAMURA Tomonori, UESHIMA Hirotsugu, OKAYAMA Akira, MIURA Katsuyuki
    日本疫学会学術総会講演集(Web) 2018年02月
  • 大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2018年02月
  • 中村保幸, 中村保幸, 岡村智教, 喜多義邦, 奥田奈賀子, 門田文, 三浦克之, 岡山明, 上島弘嗣
    日本疫学会学術総会講演集(Web) 2018年02月
  • 村上慶子, 大久保孝義, 渡邉至, 二宮利治, 大西浩文, 八谷寛, 高嶋直敬, 宮川尚子, 門田文, 奥田奈賀子, 西信雄, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2018年02月
  • 久保佐智美, 東山綾, 杉山大典, 桑原和代, 久保田芳美, 西田陽子, 平田匠, 門田文, 辰巳友佳子, 宮松直美, 宮本恵宏, 岡村智教
    日本疫学会学術総会講演集(Web) 2018年02月
  • 炭本 佑佳, 柳田 昌彦, 奥田 奈賀子, 西 信雄, 中村 好一, 宮松 直美, 中村 幸志, 宮川 尚子, 宮地 元彦, 門田 文, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2017年10月
  • 平田 あや, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 西田 陽子, 久保 佐智美, 田辺 杏由美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 2017年10月
  • 月野木 ルミ, 村上 義孝, 三浦 克之, 岡村 智教, 門田 文, 早川 岳人, 岡山 明, 上島 弘嗣, NIPPON DATA研究グループ
    日本公衆衛生学会総会抄録集 2017年10月
  • 新杉 知沙, 西 信雄, 門田 文, 寳澤 篤, 大久保 孝義, 奥田 奈賀子, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本公衆衛生学会総会抄録集 2017年10月
  • 田辺 杏由美, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 平田 あや, 西田 陽子, 久保 佐智美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 2017年10月
  • 社会経済要因と尿中ナトリウム、カリウム排泄量の関連 NIPPON DATA2010
    宮川 尚子, 奥田 奈賀子, 中川 秀昭, 嶽崎 俊郎, 西 信雄, 高嶋 直敬, 藤吉 朗, 大久保 孝義, 門田 文, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本高血圧学会総会プログラム・抄録集 2017年10月
  • 高non-HDLコレステロール者の血圧と生活習慣 NIPPON DATA 2010
    中川 夕美, 由田 克士, 岩橋 明子, 荒井 裕介, 尾島 俊之, 藤吉 明, 中川 秀昭, 西 信雄, 門田 文, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2017年10月
  • 社会経済的水準と循環器疾患危険因子認知度との関連
    辻 雅善, 有馬 久富, 大久保 孝義, 中村 幸志, 嶽崎 俊郎, 坂田 清美, 奥田 奈賀子, 西 信雄, 門田 文, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2017年10月
  • 都市部住民における飲酒と高感度CRPについての検討 神戸研究
    西田 陽子, 東山 綾, 久保田 芳美, 久保 佐智美, 平田 匠, 門田 文, 辰巳 友佳子, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本アルコール・薬物医学会雑誌 2017年08月
  • 飲酒量やアルコールに関連する肝機能マーカーと抑うつ傾向との関連
    鈴木 春満, 門田 文, 奥田 奈賀子, 西 信雄, 有馬 久富, 佐藤 敦, 近藤 慶子, 宮川 尚子, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本アルコール・薬物医学会雑誌 2017年08月
  • 血清尿酸値および飲酒習慣と腎機能との関連 神戸研究
    久保 佐智美, 東山 綾, 久保田 芳美, 西田 陽子, 平田 匠, 門田 文, 辰巳 友佳子, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本アルコール・薬物医学会雑誌 2017年08月
  • 男性の飲酒とCVD死亡の関連における脂質異常症およびγ-GTP値の影響 NIPPON DATA90
    平田 匠, 岡村 智教, 杉山 大典, 鳥居 さゆ希, 高嶋 直敬, 門田 文, Choudhury Sohel Reza, 三浦 克之, 上島 弘嗣
    日本アルコール・薬物医学会雑誌 2017年08月
  • Body Mass Indexを予測因子とした将来の新規要介護者数および介護費用の将来予測 NIPPON DATA90
    岡本 翔平, 岡村 智教, 杉山 大典, 早川 岳人, 中村 保幸, 宮川 尚子, 栗田 修司, 高嶋 直敬, 大久保 孝義, 門田 文, 藤吉 朗, 三浦 克之, 岡山 明, 上島 弘嗣, NIPPON DATA, 研究グループ
    日本動脈硬化学会総会プログラム・抄録集 2017年06月
  • 日本人一般集団におけるFatty liver indexと高血圧発症との関連 神戸研究
    平田 あや, 東山 綾, 平田 匠, 杉山 大典, 桑原 和代, 西田 陽子, 久保 佐智美, 田辺 杏由美, 久保田 芳美, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本動脈硬化学会総会プログラム・抄録集 2017年06月
  • 日本人一般男性における血中n-3系多価不飽和脂肪酸濃度と無症候性脳血管病変との関係
    近藤 慶子, 有馬 久富, 久松 隆史, 藤吉 朗, 門田 文, 関川 暁, 鳥居 さゆ希, 鈴木 仙太朗, 椎野 顯彦, 野崎 和彦, 宮川 尚子, 前川 聡, 村田 喜代史, 三浦 克之, 上島 弘嗣
    日本動脈硬化学会総会プログラム・抄録集 2017年06月
  • 一般健常男性における喫煙習慣・禁煙期間と潜在性動脈硬化指標との関連 滋賀動脈硬化疫学研究SESSA
    久松 隆史, 三浦 克之, 有馬 久富, 門田 文, 門脇 紗也佳, 鳥居 さゆ希, 鈴木 仙太朗, 宮川 尚子, 佐藤 敦, 藤吉 朗, 大久保 孝義, アボット・ロバート, 関川 暁, 堀江 稔, 上島 弘嗣
    日本動脈硬化学会総会プログラム・抄録集 2017年06月
  • 糖尿病・空腹時高血糖における血圧とCVD死亡の関連 NIPPON DATA90
    平田 匠, 岡村 智教, 門田 文, 藤吉 朗, 大久保 孝義, 岡山 明, 三浦 克之, 上島 弘嗣
    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 2017年05月
  • 生活習慣病の予防・改善の取り組みと社会的要因の関連 NIPPON DATA 2010
    五領田 小百合, 西 信雄, 寳澤 篤, 由田 克士, 荒井 裕介, 近藤 慶子, 宮川 尚子, 早川 岳人, 藤吉 朗, 門田 文, 大久保 孝義, 岡村 智教, 奥田 奈賀子, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 2017年05月
  • 日本人一般住民男性における腎異所性脂肪と肥満指標との関連 滋賀潜在性動脈硬化研究(SESSA)
    宮澤 伊都子, 大久保 孝義, 藤吉 朗, 久松 隆史, 門田 文, 村上 陽子, 永谷 幸裕, 門脇 紗也佳, 村田 喜代史, 前川 聡, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 2017年05月
  • 社会的要因と高コレステロール血症の有病・無治療との関連 NIPPON DATA2010を用いて
    藤吉 奈央子, 佐藤 敦, 有馬 久富, 尾島 俊之, 西 信雄, 奥田 奈賀子, 門田 文, 大久保 孝義, 藤吉 朗, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 2017年05月
  • 早朝及び就寝前高血圧と飲酒量との関連 神戸研究
    久保 佐智美, 東山 綾, 久保田 芳美, 杉山 大典, 桑原 和代, 西田 陽子, 平田 匠, 門田 文, 辰巳 友佳子, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本循環器病予防学会誌 2017年05月
  • 日本人一般男性における飲酒習慣と肥満指標・腹部脂肪分布(内臓脂肪・皮下脂肪)との関連 滋賀動脈硬化疫学研究SESSA
    炭 昌樹, 久松 隆史, 藤吉 朗, 門田 文, 宮川 尚子, 近藤 慶子, 門脇 紗也佳, 鈴木 仙太朗, 鳥居 さゆ希, Zaid Maryam, 佐藤 敦, 有馬 久富, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 2017年05月
  • 日本人の非糖尿病者における随時血糖・HbA1c・フルクトサミンと心血管死の関連 NIPPON DATA90
    平田 匠, 岡村 智教, 櫻井 勝, 門田 文, 中川 秀昭, 岡山 明, 三浦 克之, 上島 弘嗣
    糖尿病 2017年04月
  • 中村富予, 中村保幸, 斎藤重幸, 岡村智教, 柳田昌彦, 由田克士, 喜多義邦, 村上義孝, 横道洋司, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 村上慶子, 大久保孝義, 中村美詠子, 二宮利治, 尾島俊之, 白井佳世子, 長幡友実, 門田文, 奥田奈賀子, 西信雄, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 奥田奈賀子, 門田文, 西信雄, 三浦克之, 大久保孝義, 宮川尚子, 佐藤敦, 喜多義邦, 早川岳人, 高嶋直敬, 藤吉朗, 岡山明, 岡村智教, 上島弘嗣
    日本疫学会学術総会講演集(Web) 2017年01月
  • 大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 尾島俊之, 中村美詠子, 由田克士, 藤吉朗, 門田文, 大久保孝義, 近藤慶子, 宮川尚子, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 尾関佳代子, 尾島俊之, 中村美詠子, 柴田陽介, 西信雄, 奥田奈賀子, 門田文, 佐藤敦, 宮川尚子, 近藤慶子, 大久保孝義, 上島弘嗣, 岡村智教, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 炭本佑佳, 柳田昌彦, 奥田奈賀子, 西信雄, 中村好一, 宮松直美, 中村幸志, 宮川尚子, 宮地元彦, 門田文, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 鳥居さゆ希, 佐藤敦, 宮川尚子, 門田文, 門田文, 有馬久富, 有馬久富, 藤吉朗, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣
    日本疫学会学術総会講演集(Web) 2017年01月
  • 鈴木春満, 門田文, 奥田奈賀子, 早川岳人, 西信雄, 中村保幸, 有馬久富, 柳田昌彦, 八谷寛, 山縣然太朗, 佐藤敦, 宮川尚子, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 五領田小百合, 五領田小百合, 西信雄, 寳澤篤, 由田克士, 荒井裕介, 近藤慶子, 宮川尚子, 早川岳人, 藤吉朗, 門田文, 大久保孝義, 岡村智教, 奥田奈賀子, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 櫻井勝, 中川秀昭, 門田文, 由田克士, 中村保幸, 奥田奈賀子, 西信雄, 宮本恵宏, 有馬久富, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 岡本翔平, 岡村智教, 杉山大典, 早川岳人, 中村保幸, 宮川尚子, 栗田修司, 高島直敬, 大久保孝義, 門田文, 藤吉朗, 三浦克之, 岡山明, 上島弘嗣
    日本疫学会学術総会講演集(Web) 2017年01月
  • 平田あや, 平田あや, 東山綾, 東山綾, 平田匠, 平田匠, 杉山大典, 杉山大典, 桑原和代, 桑原和代, 西田陽子, 久保佐智美, 田辺杏由美, 田辺杏由美, 久保田芳美, 久保田芳美, 門田文, 門田文, 西川智文, 西川智文, 宮松直美, 宮松直美, 宮本恵宏, 宮本恵宏, 岡村智教, 岡村智教
    日本疫学会学術総会講演集(Web) 2017年01月
  • 今村晴彦, 小暮真奈, 喜多義邦, 中川秀昭, 寳澤篤, 岡村智教, 村上義孝, 西信雄, 奥田奈賀子, 門田文, 大久保孝義, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 中村美詠子, 尾島俊之, 長幡友実, 近藤今子, 二宮利治, 由田克士, 荒井裕介, 大久保孝義, 村上慶子, 西信雄, 村上義孝, 高嶋直敬, 奥田奈賀子, 門田文, 宮川尚子, 近藤慶子, 岡村智教, 上島弘嗣, 岡山明, 三浦克之
    日本疫学会学術総会講演集(Web) 2017年01月
  • 平田 あや, 岡村 智教, 杉山 大典, 桑原 和代, 門田 文, 藤吉 朗, 三浦 克之, 奥田 奈賀子, 大久保 孝義, 岡山 明, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2016年10月
  • 野菜の積極的摂取の留意とNa・K摂取量排泄量の関連 NIPPON DATA2010
    由田 克士, 岩橋 明子, 中川 夕美, 荒井 裕介, 宮川 尚子, 尾島 俊之, 藤吉 明, 中川 秀昭, 門田 文, 奥田 奈賀子, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2016年10月
  • 長期心血管転帰に関する単一または複数の非特異的12誘導心電図所見の独立予後因子 前向きコホート研究(Independent Prognostic Value of Single and Multiple Non-specific 12-Lead Electrocardiographic Findings for Long-term Cardiovascular Outcomes: a Prospective Cohort Study)
    澤野 充明, 香坂 俊, 岡村 智教, 猪原 拓, 杉山 大典, 白石 泰之, 渡邉 至, 中村 保幸, 東山 綾, 門田 文, 奥田 奈賀子, 村上 義孝, 大久保 孝義, 藤吉 朗, 三浦 克之, 岡山 明, 上島 弘嗣
    日本心臓病学会学術集会抄録 2016年09月
  • 糖尿病患者における肥満合併率の推移と肥満別臨床的特徴-滋賀県医師会糖尿病実態調査より
    宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫, 滋賀県医師会糖尿病実態調査委員会
    日本肥満症治療学会学術集会プログラム・抄録集 2016年07月
  • HOMA-IRと高分子量アディポネクチンの関連における肥満の影響 神戸研究
    平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 桑原 和代, 辰巳 友佳子, 平田 あや, 西田 陽子, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本肥満症治療学会学術集会プログラム・抄録集 2016年07月
  • 肥満合併糖尿病患者の臨床的特徴 滋賀県糖尿病実態調査から見た12年間の推移
    宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫
    糖尿病 2016年07月
  • 非肥満・非メタボリックシンドロームの都市部住民における高分子量アディポネクチンとHDLコレステロール・HOMA-IRとの関連:神戸研究
    平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 桑原 和代, 辰巳 友佳子, 平田 あや, 西田 陽子, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本動脈硬化学会総会プログラム・抄録集 2016年06月
  • 20年追跡一般住民コホートにおける超高値HDLコレステロールと死因別死亡の関連 NIPPON DATA90
    平田 あや, 岡村 智教, 杉山 大典, 桑原 和代, 門田 文, 藤吉 朗, 三浦 克之, 奥田 奈賀子, 大久保 孝義, 岡山 明, 上島 弘嗣
    日本動脈硬化学会総会プログラム・抄録集 2016年06月
  • 国民代表集団における腎機能低下者のリスク因子および生活習慣の状況 NIPPON DATA2010
    近藤 慶子, 門田 文, 平田 匠, 筒井 秀代, 高嶋 直敬, 喜多 義邦, 大久保 孝義, 岡村 智教, 清原 裕, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, Research Group
    日本循環器病予防学会誌 2016年05月
  • 女性ではインスリン抵抗性がBMIや腹囲と独立して血圧と関連する 神戸研究
    平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 桑原 和代, 西田 陽子, 門田 文, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本循環器病予防学会誌 2016年05月
  • 社会的要因及び生活習慣と抑うつとの関連 NIPPON DATA 2010
    鈴木 春満, 門田 文, 奥田 奈賀子, 西 信雄, 中村 保幸, 有馬 久富, 柳田 昌彦, 八谷 寛, 山縣 然太朗, 佐藤 敦, 宮川 尚子, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 2016年05月
  • 運動習慣と総死亡および死因別死亡との関連(NIPPON DATA90)
    高辻 由布子, 石黒 彩, 浅山 敬, 大久保 孝義, 三浦 克之, 門田 文, 藤吉 朗, 柳田 昌彦, 有馬 久富, 宮川 尚子, 高嶋 直敬, 喜多 義邦, 早川 岳人, 中村 保幸, 岡山 明, 岡村 智教, 上島 弘嗣, NIPPON DATA, Research Group
    日本循環器病予防学会誌 2016年05月
  • 肥満、非肥満別の各種循環器疾患危険因子と循環器疾患死亡リスクとの関連・集団寄与危険割合 NIPPON DATA80の29年間追跡結果
    宮澤 伊都子, 三浦 克之, 宮本 恵宏, 岡村 智教, 東山 綾, 辰巳 友佳子, 門田 文, 高嶋 直敬, 宮川 尚子, 近藤 慶子, 佐藤 敦, 有馬 久富, 岡山 明, 上島 弘嗣
    日本循環器病予防学会誌 2016年05月
  • 客観的に評価された歩数値とメタボリック症候群発症との関連 地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA)
    久松 隆史, 三浦 克之, 渋川 武志, 藤吉 朗, 有馬 久富, 門田 文, 宮川 尚子, 鳥居 さゆ希, 近藤 慶子, 宮澤 伊都子, 鈴木 仙太朗, 佐藤 敦, 山添 正博, 上島 弘嗣
    日本循環器病予防学会誌 2016年05月
  • 眼底検査、尿中アルブミン測定実施の現況と今後の課題 滋賀県医師会糖尿病実態調査より
    宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫
    糖尿病 2016年04月
  • MIYAZAWA Itsuko, OHKUBO Takayoshi, KADOWAKI Sayaka, FUJIYOSHI Akira, HISAMATSU Takashi, KADOTA Aya, ARIMA Hisatomi, MIURA Katsuyuki, MAEGAWA Hiroshi, UESHIMA Hirotsugu
    Circulation Journal 2016年03月
  • NGUYEN Ho N, MIYAGAWA Naoko, MIURA Katsuyuki, ABBOTT Robert D, OKUDA Nagako, YOSHITA Katsushi, ARAI Yusuke, KADOTA Aya, TAKASHIMA Naoyuki, FUJIYOSHI Akira, NAKAGAWA Hideaki, SAKATA Kiyomi, OJIMA Toshiyuki, OKAMURA Tomonori, OKAYAMA Akira, UESHIMA Hirotsugu
    Circulation Journal 2016年03月
  • 久松隆史, 三浦克之, 有馬久富, 有馬久富, 門脇紗也佳, 鳥居さゆ希, 宮川尚子, 門田文, 藤吉朗, 大久保孝義, 上島弘嗣
    Journal of Epidemiology (Web) 2016年01月
  • 鈴木仙太朗, 有馬久富, 有馬久富, 宮崎総一郎, 藤吉朗, 門田文, 門田文, 高嶋直敬, 久松隆史, 久松隆史, 鳥居さゆ希, 門脇紗也佳, 三浦克之, 三浦克之, 上島弘嗣, 上島弘嗣
    Journal of Epidemiology (Web) 2016年01月
  • 西田陽子, 西田陽子, 辰巳友佳子, 辰巳友佳子, 森本明子, 森本明子, 東山綾, 東山綾, 久保田芳美, 久保田芳美, 杉山大典, 杉山大典, 桑原和代, 桑原和代, 平田匠, 平田匠, 門田文, 門田文, 西村邦弘, 西村邦弘, 今野弘規, 今野弘規, 西川智文, 西川智文, 宮松直美, 宮松直美, 宮本恵宏, 宮本恵宏, 岡村智教, 岡村智教
    Journal of Epidemiology (Web) 2016年01月
  • 平田匠, 門田文, 奥田奈賀子, 宮川尚子, 東山綾, 村上義孝, 高嶋直敬, 近藤慶子, 筒井秀代, 藤吉朗, 大久保孝義, 喜多義邦, 岡村智教, 清原裕, 上島弘嗣, 岡山明, 三浦克之
    Journal of Epidemiology (Web) 2016年01月
  • 杉本裕子, 久松隆史, 三浦克之, 門脇紗也佳, 門田文, MARYAM Zaid, 鳥居さゆ希, 鳥居さゆ希, 宮川尚子, 佐藤敦, 斎藤祥乃, 山添正博, 有馬久富, 藤吉朗, 関川暁, 上島弘嗣
    日本循環器学会近畿地方会(Web) 2016年
  • 伊藤 隆洋, 有馬 久富, 藤吉 朗, 三浦 克之, 高嶋 直敬, 大久保 孝義, 門田 文, 早川 岳人, 宮川 尚子, 岡山 明, 岡村 智教, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2015年10月
  • 日本国民の性・年齢階級、居住地域別の一日の強度別身体活動の比較 NIPPON DATA2010
    大橋 瑞紀, 宮川 尚子, 中村 好一, 永井 雅人, 柳田 昌彦, 宮本 恵宏, 西 信雄, 奥田 奈賀子, 藤吉 朗, 大久保 孝義, 門田 文, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2015年10月
  • 野菜の積極的摂取への留意と高血圧指摘の有無の関連 NIPPON DATA2010
    由田 克士, 近藤 今子, 荒井 裕介, 尾島 俊之, 藤吉 朗, 中川 秀昭, 門田 文, 奥田 奈賀子, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2015年10月
  • 女性における20歳時及び40-75歳時のBody Mass Indexと骨密度の関連 神戸トライアル
    辰巳 友佳子, 東山 綾, 久保田 芳美, 杉山 大典, 西田 陽子, 平田 匠, 門田 文, 西村 邦宏, 今野 弘規, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 2015年10月
  • 野菜・果物摂取不足が高血圧の原因であることの認知度とその関連要因 NIPPON DATA2010
    宮川 尚子, 大久保 孝義, 門田 文, 奥田 奈賀子, 高嶋 直敬, 村上 義孝, 東山 綾, 早川 岳人, 斎藤 祥乃, 中村 好一, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本高血圧学会総会プログラム・抄録集 2015年10月
  • 医療機関や健診における高血圧の指摘の有無や治療の継続と減塩行動の関係 NIPPON DATA 2010
    由田 克士, 近藤 今子, 荒井 裕介, 尾島 俊之, 藤吉 朗, 中川 秀昭, 門田 文, 奥田 奈賀子, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本高血圧学会総会プログラム・抄録集 2015年10月
  • 家庭血圧は理想的環境下で測定した診察室血圧より冠動脈石灰化と強く関連するか? Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)
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    澤野 充明, 香坂 俊, 岡村 智教, 猪原 拓, 杉山 大典, 白石 泰之, 渡邉 至, 中村 保幸, 東山 綾, 門田 文, 奥田 奈賀子, 村上 義孝, 大久保 孝義, 三浦 克之, 岡山 明, 上島 弘嗣
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    宮澤 伊都子, 門田 文, 岡本 元純, 三浦 克之, 前川 聡, 大西 淳夫, 滋賀県医師会糖尿病実態調査委員会
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  • 高分子量アディポネクチンと骨密度の関連はBMIにより交絡する 神戸研究
    平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 門田 文, 西田 陽子, 今野 弘規, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
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    久松 隆史, 尾島 俊之, 中村 保幸, 清原 裕, 中川 秀昭, 桑原 和代, 藤吉 朗, 門田 文, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
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    平田 匠, 東山 綾, 久保田 芳美, 杉山 大典, 門田 文, 西田 陽子, 今野 弘規, 桑原 和代, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
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  • 総コレステロール高値と痩せ・肥満の関連 NIPPON DATAからみた30年の推移
    柴田 陽介, 尾島 俊之, 中村 美詠子, 桑原 和代, 宮川 尚子, 斉藤 祥乃, 中村 保幸, 清原 裕, 中川 秀昭, 藤吉 朗, 門田 文, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本循環器病予防学会誌 2015年06月
  • 循環器疾患の原因についての知識の程度と運動習慣の有無との関連 NIPPON DATA2010
    高辻 由布子, 石黒 彩, 大久保 孝義, 門田 文, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 生活習慣病に関する知識検討グループ
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  • 一般住民における塩分摂取と肥満による高血圧新規発症に対する複合リスクの検討 神戸研究
    平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 門田 文, 西田 陽子, 今野 弘規, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
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    平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 門田 文, 西田 陽子, 今野 弘規, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
    糖尿病 2015年04月
  • SAWANO Mitsuaki, KOHSAKA Shun, OKAMURA Tomonori, INOHARA Taku, SUGIYAMA Daisuke, SHIRAISHI Yasuyuki, WATANABE Makoto, NAKAMURA Yasuyuki, HIGASHIYAMA Aya, KADOTA Aya, OKUDA Nagako, MURAKAMI Yoshitaka, OHKUBO Takayoshi, MIURA Katsuyuki, OKAYAMA Akira, UESHIMA Hirotsugu
    Circ J 2015年03月
  • ZAID Maryam, FUJIYOSHI Akira, MIURA Katsuyuki, ABBOTT Robert D, OKAMURA Tomonori, TAKASHIMA Naoyuki, TORII Sayuki, SAITO Yoshino, HISAMATSU Takashi, MIYAGAWA Naoko, OHKUBO Takayoshi, KADOTA Aya, SEKIKAWA Akira, MAEGAWA Hiroshi, NAKAMURA Yasuyuki, MITSUNAMI Kenichi, UESHIMA Hirotsugu
    Circ J 2015年03月
  • HISAMATSU Takashi, MIURA Katsuyuki, FUJIYOSHI Akira, KADOWAKI Sayaka, ZAID Maryam, TORII Sayuki, KADOTA Aya, NAKAMURA Yasuyuki, HORIE Minoru, UESHIMA Hirotsugu
    Circ J 2015年03月
  • 西 信雄, 奥田 奈賀子, 早川 岳人, 藤吉 朗, 門田 文, 大久保 孝義, 坂田 清美, 岡村 智教, 古屋 好美, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2014年10月
  • 都市健康住民における塩分摂取量と塩分知覚低下および血圧との関連 神戸トライアル
    久保田 芳美, 東山 綾, 西村 邦宏, 杉山 大典, 今野 弘規, 門田 文, 西川 智文, 平田 匠, 宮松 直美, 宮本 恵宏, 岡村 智教
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  • 大腿骨近位部骨折の発症要因に関する検討 NIPPON DATA90の16年追跡
    齋藤 祥乃, 三浦 克之, 早川 岳人, 喜多 義邦, 奥田 奈賀子, 藤吉 朗, 高嶋 直敬, 宮川 尚子, 鳥居 さゆ希, 門田 文, 大久保 孝義, 岡山 明, 岡村 智教, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2014年10月
  • ナトリウムとカリウムの推定尿中排泄量およびナトリウム/カリウム比の規定要因 国民代表集団NIPPON DATA2010における検討
    宮川 尚子, 奥田 奈賀子, 中川 秀昭, 福原 正代, 新村 英士, 嶽崎 俊郎, 西 信雄, 藤吉 朗, 大久保 孝義, 門田 文, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本高血圧学会総会プログラム・抄録集 2014年10月
  • 社会的要因と高血圧有病者、未治療者、およびコントロール不良者割合との関連 NIPPON DATA2010
    佐藤 敦, 大久保 孝義, 西 信雄, 奥田 奈賀子, 阿江 竜介, 井上 まり子, 村上 慶子, 門田 文, 藤吉 朗, 坂田 清美, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本高血圧学会総会プログラム・抄録集 2014年10月
  • 日本国民における家庭血圧測定状況とその関連要因 NIPPON DATA2010
    石黒 彩, 大久保 孝義, 由田 克士, 尾島 俊之, 西 信雄, 荒井 裕介, 藤吉 朗, 門田 文, 中川 秀昭, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本高血圧学会総会プログラム・抄録集 2014年10月
  • 国民代表集団における30年間の心電図所見推移 NIPPON DATA80/90/2010及び2000年循環器疾患基礎調査の検討
    杉山 大典, 岡村 智教, 中村 好一, 中村 幸志, 香坂 俊, 東山 綾, 鳥居 さゆ希, 澤野 充明, 門田 文, 大久保 孝義, 渡邉 至, 上島 弘嗣, 岡山 明, 三浦 克之
    日本循環器病予防学会誌 2014年07月
  • 久保田芳美, 東山綾, 西村邦宏, 杉山大典, 今野弘規, 門田文, 西川智文, 平田匠, 宮松直美, 宮本恵宏, 岡村智教
    J Epidemiol 2014年01月
  • 中村保幸, 奥田奈賀子, 岡村智教, 門田文, 宮川尚子, 早川岳人, 喜多義邦, 藤吉朗, 永井雅人, 高嶋直敬, 大久保孝義, 三浦克之, 岡山明, 上島弘嗣
    Journal of Epidemiology 2014年01月
  • NIPPON DATA2010 第二回発症追跡調査の実施状況
    齋藤 祥乃, 門田 文, 大久保 孝義, 永井 雅人, 早川 岳人, 高嶋 直敬, 奥田 奈賀子, 村上 義孝, 藤吉 朗, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
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  • 国民代表集団における慢性腎臓病有病率の推定 NIPPON DATA2010
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    日本高血圧学会総会プログラム・抄録集 2013年10月
  • 国民の血圧水準および高血圧有病率・治療率・管理率の過去50年間/30年間の推移 循環器疾患基礎調査データに基づく検討
    永井 雅人, 大久保 孝義, 斎藤 重幸, 高嶋 直敬, 宮川 尚子, 村上 義孝, 門田 文, 斎藤 祥乃, 奥田 奈賀子, 西 信雄, 岡村 智教, 岡山 明, 上島 弘嗣, 三浦 克之, NIPPON DATA, 研究グループ
    日本高血圧学会総会プログラム・抄録集 2013年10月
  • 地域住民男性における生涯喫煙量と内臓脂肪との関連 SESSA研究
    藤吉 朗, 三浦 克之, 門脇 紗也佳, 門田 文, 大久保 孝義, 宮川 尚子, 久松 隆史, 齋藤 祥乃, 鳥居 さゆ希, 宮澤 伊都子, 三ツ浪 健一, 前川 聡, 村田 喜代史, 上島 弘嗣
    肥満研究 2013年09月
  • 日本人一般男性集団における脈波伝播速度と頸動脈内膜中膜肥厚および頸動脈プラークとの関連 Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)
    鳥居 さゆ希, 藤吉 朗, 門田 文, 高嶋 直敬, 門脇 紗也佳, 久松 隆史, 斎藤 祥乃, 宮川 尚子, Maryam Zaid, 大久保 孝義, 三浦 克之, 上島 弘嗣, SESSA研究グループ
    日本動脈硬化学会総会プログラム・抄録集 2013年06月
  • 日本人一般集団における高コレステロール血症の心血管疾患に対する相対リスクと人口寄与割合 NIPPON DATA80研究24年間の追跡から
    杉山 大典, 岡村 智教, 門田 文, 早川 岳人, 岡山 明, 大久保 孝義, 三浦 克之, 上島 弘嗣
    日本動脈硬化学会総会プログラム・抄録集 2013年06月
  • 高齢男性における慢性腎臓病と認知機能との関連 滋賀動脈硬化疫学研究
    藤吉 朗, 大久保 孝義, 三浦 克之, 椎野 顕彦, 宮川 尚子, 高嶋 直敬, 齋藤 祥乃, 鳥居 さゆ希, 門田 文, 門脇 紗也佳, 久松 隆史, 宮澤 伊都子, 上島 弘嗣, the SESSA Research Group
    日本循環器病予防学会誌 2013年05月
  • 日本人男性における心臓周囲脂肪と肥満指標との関連 滋賀潜在性動脈硬化研究(SESSA)
    宮澤 伊都子, 大久保 孝義, 三浦 克之, 藤吉 朗, 門脇 紗也佳, 宮川 尚子, 高嶋 直敬, 斉藤 祥乃, 鳥居 さゆ希, 久松 隆史, 門田 文, 前川 聡, 上島 弘嗣, the SESSA Research Group
    日本循環器病予防学会誌 2013年05月
  • 1日のエネルギー摂取量と死亡リスクとの関連 NIPPON DATA80
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    日本循環器病予防学会誌 2013年05月
  • 蛋白尿を呈さない2型糖尿病患者における種々の血中可溶性受容体マーカー濃度の推移と腎機能低下の関連
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    糖尿病 2013年04月
  • HISAMATSU Takashi, MIURA Katsuyuki, OHKUBO Takayoshi, FUJIYOSHI Akira, KADOTA Aya, KADOWAKI Sayaka, YAMAMOTO Takashi, MIYAGAWA Naoko, TORII Sayuki, SAITOH Yoshino, TAKASHIMA Naoyuki, MURAKAMI Yoshitaka, OKAMURA Tomonori, HORIE Minoru, UESHIMA Hirotsugu
    Circ J 2013年03月
  • HISAMATSU Takashi, MIURA Katsuyuki, OHKUBO Takayoshi, YAMAMOTO Takashi, MIYAGAWA Naoko, FUJIYOSHI Akira, KADOTA Aya, TAKASHIMA Naoyuki, OKUDA Nagako, MURAKAMI Yoshitaka, OKAMURA Tomonori, HORIE Minoru, OKAYAMA Akira, UESHIMA Hirotsugu
    Circ J 2013年03月
  • 久保田芳美, 東山綾, 西村邦宏, 杉山大典, 今野弘規, 門田文, 宮松直美, 宮本恵宏, 岡村智教
    J Epidemiol 2013年01月
  • 都市型コホート研究『神戸トライアル』における抗核抗体陽性者とシスタチンCの関係
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    臨床病理 2012年10月
  • 高齢者の外出頻度と笑顔で楽しい日常生活との関連 篠山市高齢者実態把握調査(第1報)
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    日本公衆衛生学会総会抄録集 2012年10月
  • NIPPON DATA2010(第三報) 第一回追跡調査方法の概要
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    日本公衆衛生学会総会抄録集 2012年10月
  • ストレス状況と検査時血圧および家庭血圧についての検討 神戸トライアル
    久保田 芳美, 東山 綾, 西村 邦宏, 杉山 大典, 今野 弘規, 門田 文, 宮松 直美, 宮本 恵宏, 岡村 智教
    日本公衆衛生学会総会抄録集 2012年10月
  • NIPPON DATA2010における認知度(第三報) 脳卒中の初発症状
    森本 明子, 永井 雅人, 宮松 直美, 岡村 智教, 宮川 尚子, 門田 文, 奥田 奈賀子, 高嶋 直敬, 大久保 孝義, 村上 義孝, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2012年10月
  • NIPPON DATA2010における認知度(第二報) 糖尿病に関する知識
    門田 文, 永井 雅人, 大久保 孝義, 東山 綾, 宮川 尚子, 高嶋 直敬, 村上 義孝, 奥田 奈賀子, 早川 岳人, 宮松 直美, 斎藤 重幸, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本公衆衛生学会総会抄録集 2012年10月
  • NIPPON DATA2010における認知度(第一報) 循環器疾患の危険因子
    永井 雅人, 大久保 孝義, 門田 文, 宮川 尚子, 村上 義孝, 高嶋 直敬, 奥田 奈賀子, 東山 綾, 早川 岳人, 中村 好一, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本公衆衛生学会総会抄録集 2012年10月
  • 高血圧の原因となる生活習慣の認知度 国民代表集団NIPPON DATA 2010における検討
    宮川 尚子, 大久保 孝義, 門田 文, 奥田 奈賀子, 高嶋 直敬, 村上 義孝, 東山 綾, 早川 岳人, 齋藤 祥乃, 中村 好一, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之, NIPPON DATA, 研究グループ
    日本高血圧学会総会プログラム・抄録集 2012年09月
  • 日本人一般男性集団における脈波伝播速度と冠動脈石灰化との関連 Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)
    鳥居 さゆ希, 大久保 孝義, 藤吉 朗, 門田 文, 高嶋 直敬, 門脇 紗也佳, 久松 隆史, 齋藤 祥乃, 宮川 尚子, 村上 義孝, 三浦 克之, 上島 弘嗣
    日本高血圧学会総会プログラム・抄録集 2012年09月
  • 日本人一般男性における心疾患死亡リスクに対する早期再分極とn-3不飽和脂肪酸摂取量との交互作用の検討 NIPPON DATA80
    久松 隆史, 三浦 克之, 大久保 孝義, 宮川 尚子, 藤吉 朗, 高嶋 直敬, 門田 文, 奥田 奈賀子, 村上 義孝, 堀江 稔, 岡村 智教, 岡山 明, 上島 弘嗣
    日本心臓病学会誌 2012年08月
  • 門田文, 三浦克之, 藤吉朗, 岡村智教, 門脇崇, 中村保幸, 大久保孝義, 高嶋直敬, 鳥居さゆ希, 笠置文善, 前川聡, 柏木厚典, 上島弘嗣
    日本動脈硬化学会総会・学術集会プログラム・抄録集(CD-ROM) 2012年07月
  • 生活習慣病の疫学研究から動脈硬化を予防する NIPPON DATA80リスクチャートを用いた冠動脈死亡絶対危険度と頸部動脈硬化所見との関連の検討 SESSA研究
    門田 文, 三浦 克之, 藤吉 朗, 岡村 智教, 門脇 崇, 中村 保幸, 大久保 孝義, 高嶋 直敬, 鳥居 さゆ希, 笠置 文善, 前川 聡, 柏木 厚典, 上島 弘嗣
    日本動脈硬化学会総会プログラム・抄録集 2012年07月
  • 循環器疾患による早世(65歳未満死亡)の要因の検討 NIPPON DATA80
    高嶋 直敬, 三浦 克之, 大久保 孝義, 村上 義孝, 喜多 義邦, 門田 文, 藤吉 朗, 宮川 尚子, 久松 隆史, 鳥居 さゆ希, 斎藤 祥乃, 早川 岳人, 岡村 智教, 岡山 明, 上島 弘嗣
    日本循環器病予防学会誌 2012年04月
  • UESHIMA Hirotsugu, MIURA Katsuyuki, OHKUBO Takayoshi, FUJIYOSHI Akira, KADOTA Aya, KADOWAKI Sayaka, NAKAMURA Yasuyuki, OKAMURA Tomonori, KASHIWAGI Atsunori, MAEGAWA Hiroshi, HORIE Minoru, YAMAMOTO Takashi, KIMURA Takeshi, KITA Toru
    Circ J 2012年03月
  • NAKAMURA Yasuyuki, OKAMURA Tomonori, HIGASHIYAMA Aya, WATANABE Makoto, KADOTA Aya, OHKUBO Takayoshi, MIURA Katsuyuki, KASAGI Fumiyoshi, KODAMA Kazunori, OKAYAMA Akira, UESHIMA Hirotsugu
    Circ J 2012年03月
  • KADOTA Aya, MIURA Katsuyuki, OKAMURA Tomonori, FUJIYOSHI Akira, NAKAMURA Yasuyuki, OHKUBO Takayoshi, MITSUNAMI Kenichi, MAEGAWA Hiroshi, KIMURA Takeshi, KASHIWAGI Atsunori, UESHIMA Hirotsugu
    Circ J 2012年03月
  • 市町村における特定健診受診率向上対策の検討とその効果
    宇野 裕子, 清水 めぐみ, 山澤 幸子, 門田 文, 宮川 尚子, 三浦 克之, 岡村 智教
    日本公衆衛生学会総会抄録集 2011年10月
  • 多施設共同研究による特定健診受診率向上プログラムの開発と実践
    岡村 智教, 三浦 克之, 山縣 然太朗, 安田 誠史, 木山 昌彦, 西脇 祐司, 大久保 孝義, 上島 弘嗣, 田中 太一郎, 早川 岳人, 門田 文, 宮松 直美, 村上 義孝, 舟本 美果, 西本 美和
    日本公衆衛生学会総会抄録集 2011年10月
  • 神戸トライアル(第4報) 都市住民における聴覚とメンタルヘルス
    西村 邦宏, 久保田 芳美, 東山 綾, 杉山 大典, 今野 弘規, 門田 文, 宮松 直美, 岡村 智教
    日本公衆衛生学会総会抄録集 2011年10月
  • 神戸トライアル(第3報) 都市住民における塩分知覚低下と飲酒・喫煙習慣
    宮松 直美, 久保田 芳美, 東山 綾, 杉山 大典, 今野 弘規, 門田 文, 西村 邦宏, 岡村 智教
    日本公衆衛生学会総会抄録集 2011年10月
  • 神戸トライアル(第2報) 成人してからの体重変化と動脈硬化危険因子
    久保田 芳美, 東山 綾, 西村 邦宏, 杉山 大典, 門田 文, 今野 弘規, 宮松 直美, 岡村 智教
    日本公衆衛生学会総会抄録集 2011年10月
  • 日常的な健康度を指標とした都市コホート研究 神戸トライアル(第1報) 研究デザイン
    東山 綾, 久保田 芳美, 杉山 大典, 今野 弘規, 門田 文, 西村 邦宏, 宮松 直美, 岡村 智教
    日本公衆衛生学会総会抄録集 2011年10月
  • 循環器病の予防に関する調査(NIPPON DATA2010)(第二報) 結果集計
    高嶋 直敬, 宮川 尚子, 村上 義孝, 門田 文, 大久保 孝義, 早川 岳人, 奥田 奈賀子, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2011年10月
  • 循環器病の予防に関する調査(NIPPON DATA2010)(第一報) 実施方法
    門田 文, 大久保 孝義, 高嶋 直敬, 早川 岳人, 奥田 奈賀子, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之
    日本公衆衛生学会総会抄録集 2011年10月
  • 健常者における抗核抗体陽性率 神戸トライアルからの報告
    杉山 大典, 久保田 芳美, 東山 綾, 今野 弘規, 門田 文, 西村 邦宏, 宮松 直美, 岡村 智教
    臨床病理 2011年10月
  • 地域一般住民を対象にした橈骨Augmentation Indexと心腎機能指標との関連の検討
    喜多 義邦, 高嶋 直敬, Chowdhury Turin, Nahid Rumana, 門田 文, 中村 保幸, 三浦 克之, 上島 弘嗣
    日本高血圧学会総会プログラム・抄録集 2011年10月
  • 中年期男性の"ビール腹"はビールのせいではない
    上島 弘嗣, 藤吉 朗, 門脇 紗也佳, 門脇 崇, 宮川 尚子, 門田 文, 大久保 義孝, 三浦 克之, 岡村 智教
    日本アルコール・薬物医学会雑誌 2011年08月
  • 糖尿病および耐糖能障害による心血管病発症リスクの検討 日本動脈硬化縦断研究(JALS)0次統合研究
    門田 文
    糖尿病 2011年04月
  • 特定健診受診勧奨ツールの開発と受診率向上への効果
    宮川 尚子, 門田 文, 清水 めぐみ, 山澤 幸子, 宇野 裕子, 大黒 清夏, 今堀 初美, 上島 弘嗣, 三浦 克之, 岡村 智教
    日本循環器病予防学会誌 2011年04月
  • 脂質異常症とCAVI 都市部一般住民における断面的検討 神戸トライアル
    東山 綾, 若林 一郎, 久保田 芳美, 西村 邦宏, 杉山 大典, 門田 文, 今野 弘規, 岡村 智教
    日本循環器病予防学会誌 2011年04月
  • 2型糖尿病患者の血小板活性化に対する日内血圧変動と高用量ARB投与の効果
    一色 啓二, 坂口 正芳, 門田 文, 横幕 由喜代, 久米 真二, 金崎 雅美, 荒木 信一, 杉本 俊郎, 前川 聡, 柏木 厚典, 宇津 貴
    糖尿病 2011年03月
  • HISAMATSU Takashi, OHKUBO Takayoshi, MIURA Katsuyuki, OKAMURA Tomonori, KADOTA Aya, TAKASHIMA Naoyuki, MURAKAMI Yoshitaka, HORIE Minoru, OKAYAMA Akira, UESHIMA Hirotsugu
    Circ J 2011年
  • NAGASAWA Shinya, MIURA Katsuyuki, KADOWAKI Takashi, CURB J David, FUJIYOSHI Akira, OHKUBO Takayoshi, KADOWAKI Sayaka, KADOTA Aya, TAKASHIMA Naoyuki, SEKIKAWA Akira, UESHIMA Hirotsugu
    Circulation Journal 2011年 口頭発表(一般)
  • 職域における食事性脂質改善に重点をおいた高LDLコレステロール血症保健指導の実践
    奥田 奈賀子, 原 めぐみ, 三浦 克之, 門田 文, 藤吉 朗, 村上 義孝, 清水 満理子, 舩越 傳, 上島 弘嗣, 岡村 智教
    日本循環器病予防学会誌 2010年04月
  • 2型糖尿病患者における血清可溶性受容体マーカーと糖尿病合併症との関連
    宮澤 伊都子, 小畑 利之, 吉崎 健, 門田 文, 卯木 智, 荒木 信一, 西尾 善彦, 村上 義孝, 柏木 厚典, 前川 聡
    糖尿病 2010年04月
  • KADOTA Aya, ABBOTT Robert D, MIURA Katsuyuki, HAYAKAWA Takehito, KADOWAKI Takashi, OKAMURA Tomonori, OKAYAMA Akira, CURB JD, MASAKI Kamal H, UESHIMA Hirotsugu
    J Epidemiol 2010年01月 口頭発表(一般)
  • MIURA Katsuyuki, TAKASHIMA Naoyuki, OKUDA Nagako, HAYAKAWA Takehito, KADOWAKI Takashi, KADOTA Aya, KITA Yoshikuni, OKAMURA Tomonori, OKAYAMA Akira, UESHIMA Hirotsugu
    J Epidemiol 2010年01月 口頭発表(一般)
  • 2型糖尿病患者における血小板由来マイクロパーティクル(PDMP)は、早朝血圧と関係しARBにて血圧非依存的に低下する
    坂口 正芳, 津田 安都子, 門田 文, 一色 啓二, 荒木 信一, 杉本 俊郎, 宇津 貴
    日本高血圧学会総会プログラム・抄録集 2009年10月
  • 地域住民を対象とした非肥満高血圧者用健康教育プログラムの開発・実践
    米田 志保子, 門田 文, 田中 太一郎, 安藤 大輔, 奥田 奈賀子, 三浦 克之, 上島 弘嗣, 岡村 智教
    日本公衆衛生学会総会抄録集 2009年10月
  • 門脇 紗也佳, 門脇 崇, 三浦 克之, 門田 文, 岡村 智教, 上島 弘嗣
    日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 2009年08月
  • 糖尿病と心血管障害 疫学調査結果をいかに予防に生かすか NIPPON DATAからみた糖尿病と心血管障害
    門田 文, 上島 弘嗣
    糖尿病 2009年04月
  • 喫煙による循環器疾患の過剰死亡はメタボリックシンドロームより大きい NIPPON DATA90
    高嶋 直敬, 寳澤 篤, 門田 文, 三浦 克之, 岡村 智教, 中村 保幸, 早川 岳人, 奥田 奈賀子, 門脇 崇, 村上 義孝, 喜多 義邦, 岡山 明, 上島 弘嗣
    日本循環器病予防学会誌 2009年04月
  • 境界域危険因子集積と循環器疾患死亡リスクとの関連 NIPPON DATA90,1990-2005
    氏門田 文, 三浦 克之, 寳澤 篤, 岡村 智教, 高嶋 直敬, 藤吉 朗, 早川 岳人, 村上 義孝, 喜多 義邦, 岡山 明, 中村 保幸, 上島 弘嗣
    日本循環器病予防学会誌 2009年04月
  • NAGASAWA Shinya, MIURA Katsuyuki, KADOWAKI Takashi, KADOTA Aya, OKAMURA Tomonori, NAKAMURA Yasuyuki, UESHIMA Hirotsugu, SEKIKAWA Akira
    Circ J 2009年03月
  • 滋賀県K町における健康診査未受診者の特性と生活習慣改善に対する意識についての検討
    米田 志保子, 門田 文, 田中 太一郎, 岡村 智教, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2008年10月
  • 職域で行う軽負担な内臓脂肪減少プログラム(第2報) 無作為化比較対照試験による検討
    月野木 ルミ, 田中 信子, 岡村 智教, 奥田 奈賀子, 門田 文, 宮松 直美, 盛永 美保, 柳田 昌彦, 村上 義孝, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2008年10月
  • 職域で行う軽負担な内臓脂肪減少プログラム(第1報) 保健師主体の指導の実際
    田中 信子, 月野木 ルミ, 岡村 智教, 奥田 奈賀子, 門田 文, 宮松 直美, 盛永 美保, 柳田 昌彦, 村上 義孝, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2008年10月
  • 内臓脂肪、皮下脂肪と血圧、メタボリックシンドロームの関連(ERA-JUMP研究)
    中村 保幸, 関川 暁, 門脇 崇, 環 愼二, 岡村 智教, 喜多 義邦, 門脇 紗也佳, 門田 文
    日本高血圧学会総会プログラム・抄録集 2008年10月
  • 高血圧と肥満・インスリン抵抗性との関連の日本人、日系米人、米国白人における比較 ERA JUMP研究
    門脇 崇, 関川 暁, 三浦 克之, 岡村 智教, 中村 保幸, 環 愼二, 喜多 義邦, 門田 文, 門脇 紗也佳, 上島 弘嗣
    日本高血圧学会総会プログラム・抄録集 2008年10月
  • 日本人およびハワイ在住日系人における高血圧に対する肥満の寄与割合ERA-JUMP study
    門田 文, 関川 暁, 門脇 崇, 三浦 克之, 門脇 紗也佳, 高嶋 直敬, 奥田 奈賀子, 喜多 義邦, 岡村 智教, 中村 保幸, 上島 弘嗣
    日本高血圧学会総会プログラム・抄録集 2008年10月
  • 門脇 崇, 岡村 智教, 門田 文, 門脇 紗也佳, 三浦 克之, 喜多 義邦, 上島 弘嗣
    日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 2008年08月
  • メタボリックシンドロームの形成と飲酒 日本人男性における飲酒とメタボリックシンドロームの疫学
    門脇 崇, 岡村 智教, 門田 文, 門脇 紗也佳, 三浦 克之, 喜多 義邦, 上島 弘嗣
    日本アルコール・薬物医学会雑誌 2008年08月
  • 内臓脂肪減少を目的とした軽負荷の保健指導が男性工場従業員の生活習慣に及ぼす変化
    奥田 奈賀子, 岡村 智教, 門田 文, 宮松 直美, 田中 太一郎, 盛永 美保, 柳田 昌彦, 村上 義孝, 月野木 ルミ, 田中 信子, 高田 桂子, 船越 傳, 上島 弘嗣
    日本循環器病予防学会誌 2008年04月
  • 肥満度の変化と冠動脈石灰化との関連
    門脇 崇, Sekikawa Akira, 門脇 紗也佳, 寳澤 篤, 奥田 奈賀子, 高嶋 直敬, 門田 文, 家門 裕子, 藤吉 朗, 岡村 智教, 中村 保幸, 村上 義孝, 喜多 義邦, 三浦 克之, 上島 弘嗣
    日本循環器病予防学会誌 2008年04月
  • 厳密に測定された診察室血圧値は家庭血圧値よりも高値か?
    寳澤 篤, 門脇 崇, 三浦 克之, 門脇 紗也佳, 門田 文, 高嶋 直敬, 奥田 奈賀子, 村上 義孝, 喜多 義邦, 岡村 智教, 関川 暁, 上島 弘嗣
    日本循環器病予防学会誌 2008年04月
  • HbA1Cおよび随時血糖値と全循環器疾患死亡の関連 NIPPON DATA90、1990-2000
    門田 文, 岡村 智教, 寳澤 篤, 門脇 崇, 早川 岳人, 喜多 義邦, 斉藤 重幸, 前川 聡, 岡山 明, 中村 保幸, 柏木 厚典, 上島 弘嗣
    糖尿病 2008年04月
  • NAKAMURA Yasuyuki, UESHIMA Hirotsugu, KADOTA Aya, HOZAWA Atsushi, OKAMURA Tomonori, KADOWAKI Sayaka, KADOWAKI Takashi, HAYAKAWA Takehito, KITA Yoshikuni, ABBOTT Robert, OKAYAMA Akira
    Circ J 2008年03月
  • 新入生の頭痛とうつ尺度に関するCMI調査
    五十川 泉, 小池 由香, 増田 直美, 中村 典子, 井上 誉久, 林 国雄, 門田 文, 中村 慎一, 秋口 一郎
    CAMPUS HEALTH 2008年03月
  • 自己記録表を用いた内臓脂肪減少プログラムの開発 地域における実践
    米田 志保子, 門田 文, 田中 太一郎, 岡村 智教, 柳田 昌彦, 井手 真美, 門脇 沙也佳, 東山 綾, 上島 弘嗣
    日本公衆衛生学会総会抄録集 2007年10月
  • 新入生の頭痛とうつ尺度に関するCMI調査
    五十川 泉, 小池 由香, 増田 直美, 中村 典子, 井上 誉久, 林 国雄, 門田 文, 中村 慎一, 秋口 一郎
    CAMPUS HEALTH 2007年09月
  • 危険因子の集積と循環器疾患死亡の関連 NIPPON DATA90,1990-2000
    門田 文, 寳澤 篤, 岡村 智教, 門脇 崇, 早川 岳人, 喜多 義邦, 岡山 明, 前川 聡, 中村 保幸, 柏木 厚典, 上島 弘嗣
    糖尿病 2007年04月
  • 糖尿病患者動脈硬化症評価におけるメタボリック症候群新診断基準の意義について
    門田 文, 前川 聡, 門脇 崇, 近藤 慶子, 西尾 喜彦, 岡村 智教, 上島 弘嗣, 柏木 厚典
    糖尿病 2006年06月
  • 糖尿病患者早期動脈硬化症評価におけるメタボリックシンドローム新診断基準の意義について
    門田 文, 前川 聡, 西尾 喜彦, 門脇 崇, 村上 義孝, 岡村 智教, 上島 弘嗣, 柏木 厚典
    糖尿病 2006年04月

MISC

受賞

  • 2015年 滋賀医科大学 女性研究者賞
     
    受賞者: 門田 文
  • 2010年 長寿科学振興財団 奨励賞
     
    受賞者: 門田 文

委員歴

  • - 現在   日本動脈硬化学会   評議員
  • - 現在   日本循環器病予防学会   評議員
  • - 2017年   日本疫学会   評議員