研究者データベース

河内 明宏

  • 泌尿器科学講座 教授
Last Updated :2021/11/05

研究者情報

所属

  • 泌尿器科学講座 教授

職名

  • 教授

学位

  • 医学博士
  • 博士(京都府立医科大学)

ホームページURL

J-Global ID

研究キーワード

  • 泌尿器科学   Urology   

研究分野

  • ライフサイエンス / 泌尿器科学

経歴

  • 滋賀医科大学
  • 京都府立医科大学

学歴

  •         - 1989年   京都府立医科大学   医学研究科   泌尿器科学
  •         - 1989年   京都府立医科大学   Graduate School, Division of Medicine
  •         - 1989年   京都府立医科大学   Graduate School, Division of Medicine
  •         - 1984年   京都府立医科大学   医学部   医学科
  •         - 1984年   京都府立医科大学   Faculty of Medicine
  •         - 1984年   京都府立医科大学   Faculty of Medicine

所属学協会

  • 睡眠学会   日本ME学会   自律神経学会   日本超音波医学会   日本泌尿器科学会   

研究活動情報

論文

  • Yuki Okinaka, Susumu Kageyama, Koji Nishizawa, Toru Yoshida, Satoshi Ishitoya, Yasumasa Shichiri, Chul Jang Kim, Tsuyoshi Iwata, Ryusei Yokokawa, Yutaka Arai, Zenkai Nishikawa, Hiroki Soga, Hiroshi Ushida, Yuji Sakano, Yoshio Naya, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi
    The Prostate 2021年08月 研究論文(学術雑誌) 
    BACKGROUND: In all the prefectures of Japan, with the exception of Shiga Prefecture, more than half of local governments have an organized prostate-specific antigen (PSA) screening system in place. However, in the Shiga Prefecture, only a single city performed PSA screening over the time period of this survey. The purpose of the present study was to determine the clinical, pathological, and therapeutic features of newly diagnosed prostate cancer in localities where a formally organized screening system was almost entirely absent. METHODS: A multicenter observational study was conducted in the Shiga Prefecture, which has the lowest rate of population-based PSA-screening in Japan. Patients' age, initial PSA, reasons for PSA testing, Gleason score, clinical stage, and primary treatments were surveyed. We stratified patients according to the reasons for PSA measurement, and compared the differences between groups subject to organized versus opportunistic screening. RESULTS: In the 2 years 2012 and 2017, 984 newly diagnosed prostate cancer patients were analyzed. Of these, 954 (97%) were opportunistically tested (i.e., not as part of an organized screening system), with the remaining 29 (3%) measured as part of an organized screening program. Patients in the former group exhibited a higher initial PSA value than in the organized screening group (median: 11.49 vs. 5.67 ng/ml). They also had worse clinical features, including higher Gleason score and TNM stage. More patients in the organized screening group were treated curatively than in the nonorganized screening group in terms of the primary treatment. The results were similar in a subanalysis of the patients of age 50-69 years. CONCLUSIONS: Organized PSA screening contributes to increasing the number of patients diagnosed with early-stage cancer who can be treated curatively.
  • Kazuyoshi Johnin, Yuri Mori, Shota Nakagawa, Kenichi Kobayashi, Susumu Kageyama, Akihiro Kawauchi
    International journal of urology : official journal of the Japanese Urological Association 2021年08月 研究論文(学術雑誌)
  • Shigehisa Kubota, Susumu Kageyama, Masayuki Nagasawa, Akinori Wada, Ryo Ikari, Keiji Tomita, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi
    The American journal of case reports 22 e930989  2021年07月 研究論文(学術雑誌) 
    BACKGROUND Cabazitaxel is a second-generation taxane approved for patients with metastatic castration-resistant prostate cancer (CRPC). Although cabazitaxel improves overall survival when used following docetaxel chemotherapy, duration of the clinical response is relatively short, and few patients achieve a long-term response. CASE REPORT A 71-year-old man with prostate adenocarcinoma with an initial prostate-specific antigen (PSA) level of 4956 ng/ml, Gleason score 4+5 and cTxN0M1b was referred to our department for treatment. Several therapeutic approaches, including androgen deprivation therapy, with a combination of bicalutamide and a luteinizing hormone-releasing hormone analogue, and 4 sequential hormonal therapies including flutamide, estramustine, enzalutamide, and abiraterone, all failed to prevent disease progression. Subsequently, after 5 cycles of docetaxel chemotherapy were also ineffective, cabazitaxel chemotherapy at a dose of 20 mg/m² together with prednisone and pegfilgrastim was initiated. The patient developed grade 4 thrombocytopenia during the first 4 cycles, and the dosage of cabazitaxel had to be tapered to 12.5 mg/m² by the fifth cycle. In subsequent cycles, the treatment was continued without grade 4 thrombocytopenia or any other toxicities ³grade 3. The patient achieved a long-term clinical response over 4 years and his PSA level continued to decrease, from 29.8 ng/ml at treatment initiation to a nadir of 2.0 ng/ml after the 60th cycle. CONCLUSIONS The present case is a rare example of a sustained response to low-dose cabazitaxel, and suggests its potential as a treatment option for metastatic CRPC patients. In our patient, this approach achieved a good clinical response with manageable toxicity over the long term.
  • Chul Jang Kim, Tokio Terado, Yukihiro Tambe, Ken-Ichi Mukaisho, Susumu Kageyama, Akihiro Kawauchi, Hirokazu Inoue
    International journal of oncology 59 1 2021年07月 研究論文(学術雑誌) 
    The phosphorylation of pyruvate dehydrogenase (PDH) by pyruvate dehydrogenase kinase (PDK) 4 inhibits its ability to induce a glycolytic shift. PDK4 expression is upregulated in various types of human cancer. Because PDK4 regulation is critical for metabolic changes in cancer cells, it is an attractive target for cancer therapy given its ability to shift glucose metabolism. It was previously shown that a novel PDK4 inhibitor, cryptotanshinone (CPT), suppressed the three‑dimensional (3D)‑spheroid formation of pancreatic and colorectal cancer cells. In the present study, the effects of CPT on the invasiveness of bladder cancer cells were investigated. CPT significantly suppressed the invasiveness and 3D‑spheroid formation of T24 and J82 bladder cancer cells. CPT also suppressed the phosphorylation of PDH and β‑catenin, as well as the expression of N‑cadherin, which are all critical for inducing epithelial‑mesenchymal transition (EMT). The knockdown of β‑catenin or PDK4 using specific small interfering RNAs suppressed N‑cadherin expression and invasiveness in T24 cells. An mTOR inhibitor also suppressed the phosphorylation of β‑catenin and N‑cadherin expression. Furthermore, CPT injection significantly suppressed pancreatic tumor growth and peritoneal dissemination of highly metastatic SUIT‑2 pancreatic cancer cells in a mouse orthotopic pancreatic cancer model, without evident toxicity. Moreover, immunohistochemistry analyses demonstrated decreased β‑catenin expression in CPT‑treated pancreatic tumors compared with control tumors. Taken together, these results indicate that CPT reduced the invasiveness and metastasis of bladder cancer cells by suppressing EMT via the mTOR/β‑catenin/N‑cadherin pathway.
  • Nor Idayu A Rahman, Akira Sato, Khurelbaatar Tsevelnorov, Akio Shimizu, Masahiro Komeno, Mohammad Khusni Bin Ahmat Amin, Md Rasel Molla, Joanne Ern Chi Soh, Le Kim Chi Nguyen, Akinori Wada, Akihiro Kawauchi, Hisakazu Ogita
    Cancer research 81 9 2318 - 2331 2021年05月 研究論文(学術雑誌) 
    The growth and progression of cancers are crucially regulated by the tumor microenvironment where tumor cells and stromal cells are mutually associated. In this study, we found that stomatin expression was markedly upregulated by the interaction between prostate cancer cells and stromal cells. Stomatin suppressed cancer cell proliferation and enhanced apoptosis in vitro and inhibited xenograft tumor growth in vivo. Stomatin inhibited Akt activation, which is mediated by phosphoinositide-dependent protein kinase 1 (PDPK1). PDPK1 protein stability was maintained by its binding to HSP90. Stomatin interacted with PDPK1 and interfered with the PDPK1-HSP90 complex formation, resulting in decreased PDPK1 expression. Knockdown of stomatin in cancer cells elevated Akt activation and promoted cell increase by promoting the interaction between PDPK1 and HSP90. Clinically, stomatin expression levels were significantly decreased in human prostate cancer samples with high Gleason scores, and lower expression of stomatin was associated with higher recurrence of prostate cancer after the operation. Collectively, these findings demonstrate the tumor-suppressive effect of stromal-induced stomatin on cancer cells. SIGNIFICANCE: These findings reveal that interactions with stromal cells induce expression of stomatin in prostate cancer cells, which suppresses tumor growth via attenuation of the Akt signaling axis.
  • Chul Jang Kim, Masanari Nishida, Eiki Hanada, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi
    Asian journal of endoscopic surgery 2021年04月 
    Fluorescence image-guided surgery has improved intraoperative identification of anatomic structures including visualization of vascular anatomy. Herein, indocyanine green (ICG) fluorescence imaging was applied to identify of a recurrent small tumor of renal cell carcinoma (RCC) during laparoscopic surgery. The patient underwent left laparoscopic radical nephrectomy via the retroperitoneal approach for RCC (clear cell carcinoma, pT1bN0M0) at the age of 39 years. A solitary retroperitoneal mass (14 mm in diameter) was identified in a computed tomography scan 6 years after surgery. We performed laparoscopic resection with the application of the ICG angiography, because RCC is recognized as one of the most hypervascular cancers. The tumor was clearly visualized by fluorescence. Histopathological diagnosis of the resected tumor was recurrent RCC (low grade, G1). The patient remained free of disease at 2 years after surgery. The ICG fluorescence imaging would be a useful method for identification of metastatic small lesions of RCC during laparoscopic surgery.
  • Nobuyuki Hinata, Ryoichi Shiroki, Kazunari Tanabe, Masatoshi Eto, Atsushi Takenaka, Mutsushi Kawakita, Isao Hara, Fumiya Hongo, Naokazu Ibuki, Yasutomo Nasu, Jun Teishima, Noriyasu Kawai, Akihiro Kawauchi, Tsunenori Kondo, Naoki Kawamorita, Chikara Oyama, Shigeo Horie, Masaki Shimbo, Masashi Kato, Hiroomi Kanayama, Yuya Koito, Masato Fujisawa
    International journal of urology : official journal of the Japanese Urological Association 28 4 382 - 389 2021年04月 研究論文(学術雑誌) 
    OBJECTIVE: To investigate whether robot-assisted partial nephrectomy compared with laparoscopic partial nephrectomy is effective for renal hilar tumor removal. METHODS: This was a prospective, multicenter, single-arm, open-label trial with a 2-year enrollment period. A total of 22 academic hospitals in Japan participated in the present study. Comparison with historical control values from reported studies of laparoscopic partial nephrectomy was carried out. The warm ischemia time and positive surgical margin rate were set as primary perioperative and oncological outcomes. In the historical control group, these were 27.7 min and 13%, respectively. RESULTS: The analysis population included 105 participants. The mean warm ischemia time was 20.2 (95% confidence interval 16.7-21.8; P < 0.0001 vs 27.7). Two of 103 participants (1.9%) had a positive surgical margin (95% confidence interval 0.5-6.8%). Both results satisfy the prespecified decision criteria for the superiority of robot-assisted partial nephrectomy over the historical control of laparoscopic partial nephrectomy. Resected weight and preoperative estimated glomerular filtration rate were predictive factors of functional loss of the partially nephrectomized kidney after robot-assisted partial nephrectomy. CONCLUSION: Robot-assisted partial nephrectomy for clinical T1 renal hilar tumors results in shorter warm ischemia time than and comparable positive surgical margin rate to those reported for laparoscopic partial nephrectomy.
  • 谷口 恵香, 影山 進, 茂山 千愛美, 安藤 翔太, 飯居 宏美, 芦原 英司, 堀中 真野, 酒井 敏行, 河内 明宏, 中田 晋
    日本衛生学雑誌 76 Suppl. S158 - S158 (一社)日本衛生学会 2021年03月
  • Ryo Ikari, Ken-Ichi Mukaisho, Susumu Kageyama, Masayuki Nagasawa, Shigehisa Kubota, Takahisa Nakayama, Shoko Murakami, Naoko Taniura, Hiroyuki Tanaka, Ryoji P Kushima, Akihiro Kawauchi
    International journal of molecular sciences 22 4 2021年02月 研究論文(学術雑誌) 
    The conventional two-dimensional (2D) culture is available as an in vitro experimental model. However, the culture system reportedly does not recapitulate the in vivo cancer microenvironment. We recently developed a tissueoid cell culture system using Cellbed, which resembles the loose connective tissue in living organisms. The present study performed 2D and three-dimensional (3D) culture using prostate and bladder cancer cell lines and a comprehensive metabolome analysis. Compared to 3D, the 2D culture had significantly lower levels of most metabolites. The 3D culture system did not impair mitochondrial function in the cancer cells and produce energy through the mitochondria simultaneously with aerobic glycolysis. Conversely, ATP production, biomass (nucleotides, amino acids, lipids and NADPH) synthesis and redox balance maintenance were conducted in 3D culture. In contrast, in 2D culture, biomass production was delayed due to the suppression of metabolic activity. The 3D metabolome analysis using the tissueoid cell culture system capable of in vivo cancer cell culture yielded results consistent with previously reported cancer metabolism theories. This system is expected to be an essential experimental tool in a wide range of cancer research fields, especially in preclinical stages while transitioning from in vitro to in vivo.
  • Keiko Taniguchi, Susumu Kageyama, Chiami Moyama, Shota Ando, Hiromi Ii, Eishi Ashihara, Mano Horinaka, Toshiyuki Sakai, Shigehisa Kubota, Akihiro Kawauchi, Susumu Nakata
    Cancer gene therapy 2021年01月 研究論文(学術雑誌) 
    Metabolic reprogramming leading to aerobic glycolysis, termed the "Warburg effect," is a critical property of cancer cells. However, the precise mechanisms underlying this phenomenon are not fully understood. A growing body of evidence indicates that γ-glutamylcyclotransferase (GGCT), an enzyme involved in glutathione homeostasis that is highly expressed in many types of cancer, represents a promising therapeutic target. In this study, we identified GGCT as a novel regulator of hypoxia-inducible factor-1α (HIF-1α), a transcription factor that plays a role in hypoxia adaptation promoting aerobic glycolysis. In multiple human cancer cell lines, depletion of GGCT downregulated HIF-1α at the mRNA and protein levels. Conversely, in NIH3T3 mouse fibroblasts, overexpression of GGCT upregulated HIF-1α under normoxia. Moreover, depletion of GGCT downregulated HIF-1α downstream target genes involved in glycolysis, whereas overexpression of GGCT upregulated those genes. Metabolomic analysis revealed that modulation of GGCT expression induced a metabolic switch from the citric acid cycle to glycolysis under normoxia. In addition, we found that GGCT regulates expression of HIF-1α protein via the AMPK-mTORC1-4E-BP1 pathway in PC3 cells. Thus GGCT regulates the expression of HIF-1α in cancer cells, causing a switch to glycolysis.
  • SUSUMU KAGEYAMA, KOKI MAEDA, SHIGEHISA KUBOTA, TETSUYA YOSHIDA, TAKASHI OSAFUNE, YUTAKA ARAI, HIROKI SOGA, ZENKAI NISHIKAWA, YUJI SAKANO, KEITA TAKIMOTO, CHUL JANG KIM, TOKUHIRO CHANO, AKIHIRO KAWAUCHI
    In Vivo 35 2 1141 - 1145 2021年 研究論文(学術雑誌)
  • HIROYOSHI KOIDE, SATOSHI NODA, TETSUYA YOSHIDA, SUSUMU KAGEYAMA, KAZUYA TERAMURA, TAKESHI KATO, AKIHIRO KAWAUCHI, NORIKI FUJIMOTO, TOMOHIRO TERADA
    In Vivo 35 5 2969 - 2974 2021年 研究論文(学術雑誌)
  • 滋賀県の前立腺癌患者における診断時PSA測定契機調査
    沖中 勇輝, 影山 進, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏
    日本腎泌尿器疾患予防医学研究会プログラム・抄録集 29回 31 - 31 日本腎泌尿器疾患予防医学研究会 2021年01月
  • Gamma-glutamylcycrotransferase阻害剤pro-GAの開発とその抗癌効果の検討
    影山 進, 花田 英紀, 飯居 宏美, 吉矢 拓, 谷口 恵香, 高木 寛子, 中田 晋, 河内 明宏
    日本泌尿器科学会総会 108回 860 - 860 (一社)日本泌尿器科学会総会事務局 2020年12月
  • 滋賀県の前立腺癌患者における診断時PSA測定契機調査 癌検診実施率全国最下位県の現状
    沖中 勇輝, 影山 進, 石戸谷 哲, 宮下 浩明, 吉田 徹, 横川 竜生, 金 哲將, 七里 泰正, 新井 豊, 西川 全海, 曽我 弘樹, 牛田 博, 河内 明宏
    日本泌尿器科学会総会 108回 1682 - 1682 (一社)日本泌尿器科学会総会事務局 2020年12月
  • Miwako Masugi-Tokita, Keiji Tomita, Kenichi Kobayashi, Tetsuya Yoshida, Susumu Kageyama, Hirotaka Sakamoto, Akihiro Kawauchi
    Molecular neurobiology 57 12 5208 - 5218 2020年12月 研究論文(学術雑誌) 
    Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of the group III mGluRs, which are negatively coupled to adenylate cyclase via Gi/Go proteins and localized to presynaptic active zones of the mammalian central nervous system (CNS). To elucidate the mechanism of impaired reproductivity of mGluR7 knockout (KO) mice, we investigated sexual behavior in this line, which exhibits ejaculatory disorder, although with normal sexual motivation and erectile function. To identify the site of action within the CNS responsible for the effect of mGluR7 on ejaculation, we then used a para-chloroamphetamine (PCA)-induced ejaculation model. Intrathecal administration of the mGluR7-selective antagonist 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) into the lumbosacral spinal cord inhibited PCA-induced ejaculation. Immunohistochemistry revealed mGluR7-like immunoreactivity (LI) expressed in the same area where lumbar spinothalamic (LSt) cells regulate the parasympathetic ejaculatory pathway. At high magnification, the apposition of mGluR7-LI puncta and neuronal nitric oxide synthase (nNOS)-LI-positive putative parasympathetic preganglionic neurons was evident. These results indicate that mGluR7 in the lumbosacral spinal cord regulates ejaculation by potentiating the excitability of parasympathetic preganglionic neurons. The ejaculatory disorder is a major issue in the field of male reproductive function. Erectile dysfunction (ED) can be treated by phosphodiesterase type 5 inhibitors like sildenafil (Viagra®), but the ejaculatory disorder cannot. Lack of understanding of the ejaculatory mechanism hinders the development of therapies for ejaculatory problems. This study is the first to demonstrate that mGluR7 regulates ejaculation and the results provide insight into the mechanism of ejaculation as well as a strategy for future therapies to treat ejaculatory disorders in humans.
  • Shigehisa Kubota, Tetsuya Yoshida, Susumu Kageyama, Takahiro Isono, Takeshi Yuasa, Junji Yonese, Ryoji Kushima, Akihiro Kawauchi, Tokuhiro Chano
    World journal of surgical oncology 18 1 270 - 270 2020年10月 研究論文(学術雑誌) 
    BACKGROUND: Accurate prediction of the prognosis of RCC using a single biomarker is challenging due to the genetic heterogeneity of the disease. However, it is essential to develop an accurate system to allow better patient selection for optimal treatment strategies. ARL4C, ECT2, SOD2, and STEAP3 are novel molecular biomarkers identified in earlier studies as survival-related genes by comprehensive analyses of 43 primary RCC tissues and RCC cell lines. METHODS: To develop a prognostic model based on these multiple biomarkers, the expression of four biomarkers ARL4C, ECT2, SOD2, and STEAP3 in primary RCC tissue were semi-quantitatively investigated by immunohistochemical analysis in an independent cohort of 97 patients who underwent nephrectomy, and the clinical significance of these biomarkers were analyzed by survival analysis using Kaplan-Meier curves. The prognostic model was constructed by calculation of the contribution score to prognosis of each biomarker on Cox regression analysis, and its prognostic performance was validated. RESULTS: Patients whose tumors had high expression of the individual biomarkers had shorter cancer-specific survival (CSS) from the time of primary nephrectomy. The prognostic model based on four biomarkers segregated the patients into a high- and low-risk scored group according to defined cut-off value. This approach was more robust in predicting CSS compared to each single biomarker alone in the total of 97 patients with RCC. Especially in the 36 metastatic RCC patients, our prognostic model could more accurately predict early events within 2 years of diagnosis of metastasis. In addition, high risk-scored patients with particular strong SOD2 expression had a much worse prognosis in 25 patients with metastatic RCC who were treated with molecular targeting agents. CONCLUSIONS: Our findings indicate that a prognostic model based on four novel biomarkers provides valuable data for prediction of clinical prognosis and useful information for considering the follow-up conditions and therapeutic strategies for patients with primary and metastatic RCC.
  • Tetsuya Yoshida, Yuki Okinaka, Keiji Tomita, Teruhiko Tsuru, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi
    Asian journal of endoscopic surgery 13 4 519 - 525 2020年10月 研究論文(学術雑誌) 
    INTRODUCTION: The aim of this study was to assess the perioperative outcomes of off-clamp tumor excision using soft coagulation in laparoscopic and robotic partial nephrectomy. METHODS: We retrospectively analyzed the data from 78 patients who underwent minimally invasive partial nephrectomy, using soft coagulation, at the Shiga University of Medical Science, between September 2013 and April 2017. Tumor excision and hemostasis without renal arterial clamping was performed using soft coagulation. Collecting system repair and renorrhaphy with arterial clamping were carried out only if the collecting system had been opened. RESULTS: Forty-three of the 78 patients underwent laparoscopic partial nephrectomy using soft coagulation and the other 35 patients underwent robotic partial nephrectomy using soft coagulation. The median estimated total blood loss was 73 (0-1140) mL and no patient needed a blood transfusion. No cases featured postoperative hemorrhagic events. Six patients with urinary fistula needed prolonged ureteral stenting. The median percentage change of the estimated glomerular filtration rate was -7.2 at one to 3 months after surgery. CONCLUSION: The off-clamp soft coagulation technique in laparoscopic partial nephrectomy and robotic partial nephrectomy is a safe and feasible approach to excise kidney tumors. This procedure may reduce the incidence of perioperative hemorrhagic complications.
  • 沖中 勇輝, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本老年泌尿器科学会誌 33 1 146 - 146 日本老年泌尿器科学会 2020年08月
  • Tryggve Nevéus, Eliane Fonseca, Israel Franco, Akihiro Kawauchi, Larisa Kovacevic, Anka Nieuwhof-Leppink, Ann Raes, Serdar Tekgül, Stephen S Yang, Søren Rittig
    Journal of pediatric urology 16 1 10 - 19 2020年02月 研究論文(学術雑誌) 
    BACKGROUND: Enuresis is an extremely common condition, which, although somatically benign, poses long-term psychosocial risks if untreated. There are still many misconceptions regarding the proper management of these children. AIM: A cross-professional team of experts affiliated with the International Children's Continence Society (ICCS) undertook to update the previous guidelines for the evaluation and treatment of children with enuresis. METHODS: The document used the globally accepted ICCS terminology. Evidence-based literature served as the basis, but in areas lacking in primary evidence, expert consensus was used. Before submission, a full draft was made available to all ICCS members for additional comments. RESULTS: The enuretic child does, in the absence of certain warning signs (i.e., voiding difficulties, excessive thirst), not need blood tests, radiology or urodynamic assessment. Active therapy is recommended from the age of 6 years. The most important comorbid conditions to take into account are psychiatric disorders, constipation, urinary tract infections and snoring or sleep apneas. Constipation and daytime incontinence, if present, should be treated. In nonmonosymptomatic enuresis, it is recommended that basic advice regarding voiding and drinking habits be provided. In monosymptomatic enuresis, or if the above strategy did not make the child dry, the first-line treatment modalities are desmopressin or the enuresis alarm. If both these therapies fail alone or in combination, anticholinergic treatment is a possible next step. If the child is unresponsive to initial therapy, antidepressant treatment may be considered by the expert. Children with concomitant sleep disordered breathing may become dry if the airway obstruction is removed.
  • Tsunehito Horii, Hiroyuki Tsujimoto, Susumu Kageyama, Tetsuya Yoshida, Kenichi Kobayashi, Hideki Takamori, Hiroshi Minato, Jo Ueda, Akeo Hagiwara, Hiroshi Ichikawa, Akihiro Kawauchi
    Bio-medical materials and engineering 31 6 351 - 360 2020年 研究論文(学術雑誌) 
    BACKGROUND: To overcome the unfavorable issues associated with conventional anti-adhesive HA/CMC film, we developed an anti-adhesive thermally cross-linked gelatin film. OBJECTIVE: We tried to clarify the re-attachability of the film and the required properties concerning the film thickness, stiffness and anti-adhesion effect. METHODS: To determine the optimal thickness, 5 kinds of the thickness of gelatin film and the conventional film were analyzed by the tensile test, shearing test, buckling test and tissue injury test. Finally, using the optimal film thickness, we tried to clarify the anti-adhesion effect of the reattached film. RESULTS: The tensile and shearing test showed gelatin films ≥30 μm thick had greater tensile strength and a smaller number of film fractures, than the conventional film. The buckling and tissue injury test showed gelatin films ≥60 μm thick had higher buckling strength and worse injury scores than the conventional film. The anti-adhesive effect of re-attached gelatin film using optimal thickness (30-40 μm) found the anti-adhesion score was significantly better than that of the control. CONCLUSIONS: Provided it has an optimal thickness, gelatin film can be reattached with enough physical strength not to tear, safety stiffness not to induce tissue injury, and a sufficient anti-adhesion effect.
  • Ryo Fujiwara, Kentaro Inamura, Takeshi Yuasa, Noboru Numao, Shinya Yamamoto, Hitoshi Masuda, Akihiro Kawauchi, Kengo Takeuchi, Junji Yonese
    International journal of clinical oncology 25 1 151 - 157 2020年01月 研究論文(学術雑誌) 
    BACKGROUND: Nivolumab, which has a promising anti-tumor efficacy and a manageable safety profile, has being rapidly introduced in metastatic renal cell cancer therapy in Japan. We evaluated the efficacy and adverse events of nivolumab in real world clinical practice in Japan. METHODS: The medical records of 45 consecutive patients who started treatment with nivolumab, up to September 2018, were reviewed and statistically analyzed. RESULTS: The median follow-up period was 22.3 months. The best responses were a complete response in three patients (8%), a partial response in 14 patients (36%), stable disease in 14 patients (36%), and progressive disease in eight patients (20%). The median progression-free survival period and 1 year progression-free survival rate were 14.9 months and 54.5%, respectively. The estimated overall survival period and 1-year and 2-year overall survival rates from initiation of nivolumab were not reached, and 91.1%, and 86.2%, respectively. Twenty-seven patients (60%) experienced adverse events including four (10%) severe adverse events (Grade 3 or 4). The most common adverse event was rash (n = 9, 20%). Five patients discontinued nivolumab therapy, because of an adverse event (Grade 3 diarrhea, one patient; Grade 2 fatigue, one patient; Grade 3 uveitis, two patients; and Grade 3 adrenal insufficiency, one patient). CONCLUSIONS: Nivolumab has a relatively favorable efficacy and safety profile for Japanese metastatic renal cell cancer patients in clinical practice.
  • Masayuki Nagasawa, Kosuke Tomimatsu, Koji Terada, Kenta Kondo, Kazuko Miyazaki, Masaki Miyazaki, Daisuke Motooka, Daisuke Okuzaki, Tetsuya Yoshida, Susumu Kageyama, Hiroshi Kawamoto, Akihiro Kawauchi, Yasutoshi Agata
    Biochemical and Biophysical Research Communications 526 1 128 - 134 2020年 [有り][無し]
     研究論文(学術雑誌) 
    © 2020 Elsevier Inc. Androgen receptor (AR)-negative castration-resistant prostate cancer (CRPC) is highly aggressive and is resistant to most of the current therapies. Bromodomain and extra terminal domain (BET) protein BRD4 binds to super-enhancers (SEs) that drive high expression of oncogenes in many cancers. A BET inhibitor, JQ1, has been found to suppress the malignant phenotypes of prostate cancer cells, however, the target genes of JQ1 remain largely unknown. Here we show that SE-associated genes specific for AR-negative CRPC PC3 cells include genes involved in migration and invasion, and that JQ1 impairs migration and invasion of PC3 cells. We identified a long non-coding RNA, MANCR, which was markedly down-regulated by JQ1, and found that BRD4 binds to the MANCR locus. MANCR knockdown led to a significant decrease in migration and invasion of PC3 cells. Furthermore, RNA sequencing analysis revealed that expression of the genes involved in migration and invasion was altered by MANCR knockdown. In summary, our data demonstrate that MANCR plays a critical role in migration and invasion of PC3 cells.
  • Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema
    Nature communications 10 1 5517 - 5517 2019年12月 研究論文(学術雑誌) 
    Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However, the key pathological processes underlying cyst development and exacerbation in pre-symptomatic stages remain unknown, because rodent models do not recapitulate critical disease phenotypes, including disease onset in heterozygotes. Here, using CRISPR/Cas9, we generate ADPKD models with PKD1 mutations in cynomolgus monkeys. As in humans and mice, near-complete PKD1 depletion induces severe cyst formation mainly in collecting ducts. Importantly, unlike in mice, PKD1 heterozygote monkeys exhibit cyst formation perinatally in distal tubules, possibly reflecting the initial pathology in humans. Many monkeys in these models survive after cyst formation, and cysts progress with age. Furthermore, we succeed in generating selective heterozygous mutations using allele-specific targeting. We propose that our models elucidate the onset and progression of ADPKD, which will serve as a critical basis for establishing new therapeutic strategies, including drug treatments.
  • ニボルマブが著効した転移性腎細胞癌の1例
    小崎 成昭, 水流 輝彦, 小田 和哉, 鈴木 友里, 山崎 友莉, 吉田 啓介, 沖中 勇輝, 富田 圭司, 村井 亮介, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    泌尿器科紀要 65 11 485 - 485 泌尿器科紀要刊行会 2019年11月
  • BEP療法終了3ヵ月後に薬剤性間質性肺炎を認めた精巣腫瘍の1例
    鈴木 友理, 村井 亮介, 小崎 成昭, 山崎 友莉, 吉田 啓介, 小田 和哉, 沖中 勇輝, 小林 憲市, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    泌尿器科紀要 65 11 486 - 487 泌尿器科紀要刊行会 2019年11月
  • Koki Maeda, Susumu Kageyama, Takashi Osafune, Yoshikata Masuda, Shota Nakagawa, Kenji Miki, Shun Esumi, Maiko Kakita-Kobayashi, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi
    IJU case reports 2 6 327 - 329 2019年11月 
    Introduction: Inappropriate antidiuretic hormone secretion syndrome can be a serious adverse event of cisplatin-based chemotherapy. Cisplatin had to be changed to other drugs or chemotherapy completely discontinued in earlier reported cases. Case presentation: Three cycles of bleomycin, etoposide, and cisplatin chemotherapy were planned for a 40-year-old man with a diagnosis of lymph node recurrence of testicular cancer. On day 9, he suffered from vomiting and mental disturbance. Severe hyponatremia (110 mEq/L) with low plasma osmolality led to a diagnosis of a syndrome of inappropriate antidiuretic hormone secretion, and infusions of hypertonic saline and salt intake were prescribed. Second and third courses of bleomycin, etoposide, and cisplatin chemotherapy could then be given with careful electrolyte management. Conclusion: Continuation of cisplatin administration with precise electrolyte adjustment can be a treatment option in regimens where cisplatin is essential for achieving optimal antitumor efficacy.
  • 両側単一尿管異所開口、低形成膀胱に対し、段階的尿路再建術を行った1例
    森 友莉, 上仁 数義, 水流 輝彦, 窪田 成寿, 河内 明宏
    日本排尿機能学会誌 30 1 257 - 257 (一社)日本排尿機能学会 2019年09月
  • 排尿筋過活動および低活動性膀胱を伴う前立腺肥大症患者に対するHoLEPの短期治療成績の検討
    窪田 成寿, 永澤 誠之, 和田 晃典, 富田 圭司, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本排尿機能学会誌 30 1 326 - 326 (一社)日本排尿機能学会 2019年09月
  • Taniguchi K, Ii H, Kageyama S, Takagi H, Chano T, Kawauchi A, Nakata S
    Biochemical and biophysical research communications 517 2 238 - 243 2019年09月 [有り][無し]
     研究論文(学術雑誌) 
    Inhibition of gamma-glutamylcyclotransferase (GGCT), which is highly expressed in various cancer tissues, exerts anticancer effects both in vitro and in vivo. Previous studies have shown that depletion of GGCT blocks the growth of MCF7 breast cancer cells via upregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21); in addition, induction of autophagy plays a role in the upregulation of p21 upon GGCT knockdown. However, the mechanisms underlying induction of p21 in cancer cells are not fully understood. Here, we show that GGCT knockdown in PC3 human prostate cancer and A172 glioblastoma cells upregulates the mRNA and nuclear protein levels of Forkhead box O transcription factor 3a (FOXO3a), a transcriptional factor involved in tumor suppression. Simultaneous knockdown of FOXO3a and GGCT in PC3 and A172 cells attenuated upregulation of p21, followed by growth inhibition and cell death. Furthermore, simultaneous knockdown of GGCT and AMP-activated protein kinase (AMPK) α, a metabolic stress sensor, in PC3 and A172 cells led to marked attenuation of cellular responses induced by GGCT knockdown, including an increase in FOXO3a phosphorylation at Ser413, upregulation of p21, growth inhibition, and cell death. These results indicate that the AMPK-FOXO3a-p21 axis plays an important role in inhibition of cancer cell growth by depletion of GGCT.
  • Takagi H, Ii H, Kageyama S, Hanada E, Taniguchi K, Yoshiya T, Chano T, Kawauchi A, Nakata S
    Anticancer research 39 9 4811 - 4816 2019年09月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND/AIM: γ-Glutamylcyclotransferase (GGCT) is highly expressed in many forms of cancer, and is a promising therapeutic target. The present study investigated whether inhibition of GGCT enhanced the antiproliferative effects of the drug docetaxel in prostate cancer cells. MATERIALS AND METHODS: Immunohistochemistry and western blot analysis were conducted to measure GGCT expression in prostate cancer tissue samples and cell lines. GGCT was inhibited using RNAi and a novel enzymatic inhibitor, pro-GA, and cell proliferation was evaluated with single and combination treatments of GGCT inhibitors and docetaxel. RESULTS: GGCT was highly expressed in cultured prostate cancer cells and patient samples. GGCT inhibition alone inhibited prostate cancer cell line proliferation and induced cellular senescence. GGCT inhibition in combination with apoptosis-inducing docetaxel had more potent antiproliferative effects than either drug used alone. CONCLUSION: GGCT inhibition may potentiate anticancer drug efficacy.
  • 永澤 誠之, 成田 充弘, 小林 憲市, 富田 圭司, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏
    泌尿器外科 32 8 1057 - 1060 医学図書出版(株) 2019年08月 
    ロボット支援腹腔鏡下前立腺全摘除術において神経温存が術後尿禁制の獲得に寄与しているかを後方視的に検討した。神経非温存群109例、神経温存群94例であった。術後1ヵ月の尿禁制においては、神経温存群が有意に良好であり、多変量解析においても神経温存のみが有意な要因であった。術後3ヵ月以降においては、両群間に有意差を認めなかった。断端陽性率は両群で差を認めなかった。神経温存は早期の尿禁制獲得に寄与していた。(著者抄録)
  • ロボット腎部切における手技の工夫 ソフト凝固併用off-clamp RAPN
    吉田 哲也, 草場 拓人, 富田 圭司, 村井 亮介, 水流 輝彦, 影山 進, 成田 充弘, 河内 明宏
    腎癌研究会会報 49 25 - 25 (一社)腎癌研究会 2019年07月
  • 小林 憲市, 佐藤 亘, 中川 翔太, 山崎 友莉, 上仁 数義, 河内 明宏
    日本小児泌尿器科学会雑誌 28 1 34 - 37 日本小児泌尿器科学会 2019年06月 
    【症例】13歳、男性。繰り返す有熱性尿路感染症精査のため近医泌尿器科を受診、VCUGにて両側膀胱尿管逆流(以下VUR)と診断され、治療目的に当科紹介となった。左腎の著明な萎縮、血清Cr値とシスタチンCの高値を認め、CKD stage3と診断された。外科的治療との適応と判断し、気膀胱下逆流防止術を施行した。手術は術中合併症なく施行され、術中に尿管口から尿流出を確認したため、尿管ステントは留置しなかった。術翌日より血清Cr値が進行性に上昇し、急性腎不全を呈した。一過性の吻合部狭窄による腎後性腎不全も考慮されたが、臨床経過から、薬剤性腎障害(以下DKI)による腎性腎不全の可能性が最も高いと推測された。被疑薬の中止とステロイド投与にて、血清Cr値は徐々に低下し、退院時には術前の値まで改善した。DLSTでは、アセトアミノフェンが陽性であった。【考察】VURの手術後に、一過性の吻合部狭窄をきたすことは珍しくなく、特に単腎症例においては術後の腎後性腎不全に注意を必要とする。また、CKD患者において薬剤が腎機能障害の進行を早めることは、日常臨床では高頻度に経験する。今回、CKD Stage III、機能的単腎症例に対する両側VURの術直後に、薬剤性腎障害(以下DKI)による急性腎不全を呈した症例を経験したので報告する。【結論】VUR術後の急性腎不全においては、DKIも考慮する必要があると思われる。(著者抄録)
  • 河内 明宏, 上仁 数義, 小林 憲市, 森 友莉
    日本小児泌尿器科学会雑誌 28 2 128 - 128 日本小児泌尿器科学会 2019年06月
  • 森 友莉, 上仁 数義, 森 和徳, 猪飼 信康, 森谷 鈴子, 田口 俊亮, 沖中 勇輝, 小林 憲市, 水流 輝彦, 成田 充弘, 河内 明宏
    日本小児泌尿器科学会雑誌 28 2 161 - 161 日本小児泌尿器科学会 2019年06月
  • 上仁 数義, 森 友莉, 中川 翔太, 佐藤 亘, 小林 憲市, 河内 明宏
    日本小児泌尿器科学会雑誌 28 2 171 - 171 日本小児泌尿器科学会 2019年06月
  • 小林 憲市, 森 友莉, 上仁 数義, 河内 明宏
    日本小児泌尿器科学会雑誌 28 2 227 - 227 日本小児泌尿器科学会 2019年06月
  • 前立腺全摘除術後にイレウスから敗血症を併発し重篤化した1例
    富田 圭司, 小林 憲市, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏, 佐藤 亘, 田口 俊亮
    泌尿器科紀要 65 6 224 - 225 泌尿器科紀要刊行会 2019年06月
  • 滋賀医科大学における去勢抵抗性前立腺癌に対する塩化ラジウム223の初期使用経験
    村井 亮介, 成田 充弘, 上仁 数義, 影山 進, 吉田 哲也, 小林 憲市, 富田 圭司, 沖中 勇輝, 和田 晃典, 永澤 誠之, 窪田 成寿, 河内 明宏
    泌尿器科紀要 65 6 227 - 227 泌尿器科紀要刊行会 2019年06月
  • 進行性腎癌に対するニボルマブ治療の臨床的検討
    永澤 誠之, 吉田 哲也, 沖中 勇輝, 窪田 成寿, 和田 晃典, 小林 憲市, 富田 圭司, 村井 亮介, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    泌尿器科紀要 65 6 246 - 247 泌尿器科紀要刊行会 2019年06月
  • Yasunari Seita, Tomoyuki Tsukiyama, Takuya Azami, Kenichi Kobayashi, Chizuru Iwatani, Hideaki Tsuchiya, Masataka Nakaya, Hideyuki Tanabe, Seiji Hitoshi, Hiroyuki Miyoshi, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema
    Biology of reproduction 100 6 1440 - 1452 2019年06月 研究論文(学術雑誌) 
    Nonhuman primates (NHPs) are considered to be the most valuable models for human transgenic (Tg) research into disease because human pathology is more closely recapitulated in NHPs than rodents. Previous studies have reported the generation of Tg NHPs that ubiquitously overexpress a transgene using various promoters, but it is not yet clear which promoter is most suitable for the generation of NHPs overexpressing a transgene ubiquitously and persistently in various tissues. To clarify this issue, we evaluated four putative ubiquitous promoters, cytomegalovirus (CMV) immediate-early enhancer and chicken beta-actin (CAG), elongation factor 1α (EF1α), ubiquitin C (UbC), and CMV, using an in vitro differentiation system of cynomolgus monkey embryonic stem cells (ESCs). While the EF1α promoter drove Tg expression more strongly than the other promoters in undifferentiated pluripotent ESCs, the CAG promoter was more effective in differentiated cells such as embryoid bodies and ESC-derived neurons. When the CAG and EF1α promoters were used to generate green fluorescent protein (GFP)-expressing Tg monkeys, the CAG promoter drove GFP expression in skin and hematopoietic tissues more strongly than in ΕF1α-GFP Tg monkeys. Notably, the EF1α promoter underwent more silencing in both ESCs and Tg monkeys. Thus, the CAG promoter appears to be the most suitable for ubiquitous and stable expression of transgenes in the differentiated tissues of Tg cynomolgus monkeys and appropriate for the establishment of human disease models.
  • 上仁 数義, 小林 憲市, 河内 明宏
    臨床泌尿器科 73 4 174 - 178 (株)医学書院 2019年04月 
    <文献概要>Point ▼臍と5mm以下の2つの術創で行う腹腔鏡下腎盂形成術であり,美容的に優れている.▼小児例ややせた女性が最もよい適応である.▼高度な炎症がある場合,馬蹄鉄腎など複雑な解剖が予想される場合,肥満などの場合は,追加ポートが必要になる.
  • 腎癌腎門部リンパ節転移との鑑別が困難であった異所性副腎の1例
    山崎 友莉, 小崎 成昭, 吉田 啓介, 鈴木 友理, 小田 和哉, 沖中 勇輝, 富田 圭司, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    泌尿器科紀要 65 4 134 - 134 泌尿器科紀要刊行会 2019年04月
  • 気膀胱下逆流防止術における手術時間に影響する因子の検討
    小林 憲市, 上仁 数義, 沖中 勇輝, 窪田 成寿, 永澤 誠之, 和田 晃典, 村井 亮介, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏
    日本泌尿器科学会総会 107回 OP - 064 (一社)日本泌尿器科学会総会事務局 2019年04月
  • 自排尿可能な二分脊椎患者における尿流測定検査の意義
    上仁 数義, 窪田 成寿, 小林 憲市, 河内 明宏
    日本泌尿器科学会総会 107回 OP - 074 (一社)日本泌尿器科学会総会事務局 2019年04月
  • CSA(contact surface area)はソフト凝固併用ロボット・腹腔鏡下腎部分切除術における長期腎機能の予測因子となりうる
    吉田 哲也, 沖中 勇輝, 小林 憲市, 富田 圭司, 村井 亮介, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本泌尿器科学会総会 107回 OP - 367 (一社)日本泌尿器科学会総会事務局 2019年04月
  • 膀胱全摘除術各術式における周術期パラメータの比較
    沖中 勇輝, 富田 圭司, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本泌尿器科学会総会 107回 OP - 372 (一社)日本泌尿器科学会総会事務局 2019年04月
  • 当院におけるTUR-Pとホルミウムレーザー前立腺核出術(HoLEP)の比較検討
    水流 輝彦, 沖中 勇輝, 富田 圭司, 村井 亮介, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本泌尿器科学会総会 107回 PP1 - 107 (一社)日本泌尿器科学会総会事務局 2019年04月
  • 当院における精索静脈瘤に対する単孔式腹腔鏡下高位結紮術の治療成績
    富田 圭司, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本泌尿器科学会総会 107回 PP1 - 310 (一社)日本泌尿器科学会総会事務局 2019年04月
  • 当院における転移性前立腺癌に対する局所治療の治療効果
    成田 充弘, 和田 晃典, 永澤 誠之, 沖中 勇輝, 窪田 成寿, 村井 亮介, 小林 憲市, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏
    日本泌尿器科学会総会 107回 PP2 - 032 (一社)日本泌尿器科学会総会事務局 2019年04月
  • 転移性ホルモン未治療前立腺癌に対するアビラテロン併用ホルモン治療の初期経験
    永澤 誠之, 田口 俊亮, 中川 翔太, 和田 晃典, 佐野 太一, 村井 亮介, 花田 英紀, 吉田 哲也, 曽我 弘樹, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本泌尿器科学会総会 107回 PP3 - 027 (一社)日本泌尿器科学会総会事務局 2019年04月
  • Hanada E, Kageyama S, Murai R, Kubota S, Ii H, Nakata S, Kita H, Kawauchi A, Chano T
    Anticancer research 39 4 1893 - 1898 2019年04月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND/AIM: γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHODS: Immuno-histochemistry was used to evaluate GGCT expression in bladder tumors. The growth inhibitory effect of pro-GA, a novel GGCT inhibitor, in the presence or absence of mitomycin C (MMC) was assessed in three distinct bladder cancer cell lines. RESULTS: Over half of the clinical bladder tumor samples overexpressed GGCT. Pro-GA reduced the growth of all bladder cancer cell lines in a dose-dependent manner, and increased the anti-tumor effect of MMC. CONCLUSION: Inhibition of GGCT using pro-GA provides a novel therapeutic strategy for the treatment of bladder cancers.
  • Kobayashi K, Tsukiyama T, Nakaya M, Kageyama S, Tomita K, Murai R, Yoshida T, Narita M, Kawauchi A, Ema M
    Stem cell research 37 101439 - 101439 2019年04月 [有り][無し]
     研究論文(学術雑誌) 
    Cynomolgus monkey ES (Cyn ES) cells can be generated in a similar manner as human ES cells. However, Cyn ES cells are difficult to maintain in an undifferentiated state by untrained researchers. For easier culture, we generated an OCT3/4-P2A tdTomato IRES ZeocinR Cyn ES cell line using CRISPR/Cas9 genome editing technology. The stop codon of the endogenous OCT3/4 locus was replaced with the P2A tdTomato IRES ZeocinR pA cassette by homologous recombination. This cell line enables us to isolate pluripotent stem cells and exclude differentiated cells by addition of zeocin, especially for culture without feeder cells.
  • 腎癌術後再発との鑑別に苦慮した副脾の1例
    沖中 勇輝, 小田 和哉, 佐藤 亘, 中川 翔太, 伊狩 亮, 富田 圭司, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    泌尿器科紀要 65 3 95 - 95 泌尿器科紀要刊行会 2019年03月
  • Kazuyoshi Johnin, Kenichi Kobayashi, Teruhiko Tsuru, Tetsuya Yoshida, Susumu Kageyama, Akihiro Kawauchi
    International journal of urology : official journal of the Japanese Urological Association 26 2 160 - 171 2019年02月 研究論文(学術雑誌) 
    Voiding cystourethrography is the most important fluoroscopic examination in pediatric urology for the investigation of lower urogenital tract diseases, such as vesicoureteral reflux or urethral stricture. However, this invasive procedure imposes a significant burden on children and their parents, and recently there has been a paradigm shift in the diagnosis and treatment of vesicoureteral reflux. In the 2011 revision, the American Academy of Pediatrics guidelines on urinary tract infection recommended abandoning routine voiding cystourethrography after the first febrile urinary tract infection. In 2014, the randomized intervention for children with vesicoureteral reflux study recommended discontinuation of routine continuous antibiotic prophylaxis for vesicoureteral reflux. The time is now ripe to radically reconsider indications for voiding cystourethrography and the procedure itself.
  • Masayuki Nagasawa, Susumu Kageyama, Tetsuya Yoshida, Yuki Okinaka, Shigehisa Kubota, Akinori Wada, Kenichi Kobayashi, Keiji Tomita, Ryosuke Murai, Teruhiko Tsuru, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi
    Oncology letters 17 2 2551 - 2556 2019年02月 研究論文(学術雑誌) 
    The present study evaluated the impact of nedaplatin-containing chemotherapy on renal function in 35 patients with urothelial carcinoma (UC) between 2001 and 2014 who were unfit for cisplatin treatment. As comparative controls, the present study also examined 35 patients with the same disease who underwent cisplatin-containing chemotherapy during the same period. The changes in the estimated glomerular filtration rate (eGFR) prior to and following the administration of nedaplatin during each cycle of chemotherapy was investigated. The present study also reported the overall response rates and adverse events in each group. A total of 31 cycles of the gemcitabine/nedaplatin regimen and 66 cycles of the methotrexate/epirubicin/nedaplatin regimen were administered. In the nedaplatin group, the mean eGFRs prior to and following chemotherapy were 45.4 and 47.8 ml/min/1.73 m2, respectively. The eGFR of the post-chemotherapy group was significantly increased (P<0.001). On the other hand, in the cisplatin group, the eGFR following chemotherapy was significantly lower than the rate prior to chemotherapy (P<0.001). The overall response rates were 30.4 and 66.7% in the nedaplatin and cisplatin groups, respectively. In the two groups, myelosuppression was the most common side effect, but the occurrence rates in both groups were similar, and these adverse events were manageable. With regard to nephrotoxicity, nedaplatin-containing chemotherapy for cisplatin-unfit patients with UC is a safe treatment modality.
  • 中家 雅隆, 中川 孝博, 福田 浩司, 岩切 哲平, 和泉 博之, 板垣 伊織, 中村 紳一朗, 河内 明宏, 依馬 正次, 築山 智之, 小林 憲市, 岩谷 千鶴, 土屋 英明, 清田 弥寿成, 松下 淳, 北島 郁, 河本 育士
    日本繁殖生物学会 講演要旨集 112 0 P - 103-P-103 日本繁殖生物学会 2019年 

    【目的】常染色体優性多発性嚢胞腎(Autosomal dominant polycystic kidney disease ,ADPKD)は,最も頻度の高い遺伝的疾患の一つであり,嚢胞腎モデル動物を用いた研究が多数報告されているものの,未だ,決定的な治療法は存在しない。その理由の一つとして,嚢胞腎モデルのほとんどがマウスやラットのような小動物であり,ADPKDの病態を正確に再現できないことが挙げられる。重要なことに,ヒトではPKD1遺伝子のヘテロ変異で弱年齢から嚢胞発生することが知られているのに対し,Pkd1ヘテロマウスでは生存期間中にほとんど嚢胞発生を認めない。本研究では,CRISPR/Cas9を用いることで,カニクイザルにおいてADPKDモデルを作出し,ヒトのADPKDの病態を正確に再現することを目的とした。【方法】ADPKDモデルカニクイザルを作出するため,Pkd1遺伝子を標的としたsgRNA mRNAとCas9 mRNA,あるいはRNP複合体を,カニクイザルICSI胚にインジェクションし,KO効率の検討と,産仔の作出を行った。流産,あるいは生後死亡した個体は,組織を回収し,組織学的,分子生物学的解析を行った。【結果および考察】インジェクションした胚の90%以上で標的領域において変異を検出した。また,流産胎仔の解析により,Pkd1 KOカニクイザルにおける腎臓の極端な肥大,肝臓,膵臓での嚢胞発生を確認,Pkd1ヘテロカニクイザルにおいても胎仔期,幼若期からの嚢胞形成を確認した。さらに,生存産仔においても,腎臓における嚢胞発生をエコー検査によって確認した。これらの結果より,CRISPR/Cas9によるPkd1遺伝子の変異誘導により,カニクイザルにおいてADPKDの病態を再現できることが示された。今後,これらのモデルカニクイザルを用いることにより,従来は難しかった若年期の病理解析や投薬実験,長期に渡る経過観察が可能となり,ADPKDの発症機構の解明や創薬への貢献が期待される。

  • Koki Maeda, Yutaka Arai, Masanari Nishida, Wataru Sato, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 110 2 144 - 147 2019年 研究論文(学術雑誌) 
    Ureterosciatic hernia is an uncommon condition that can cause ureteral obstruction. Here, we report a case of ureterosciatic hernia successfully treated by ureteral stent placement. A 95-year old woman presented to our emergency department with high fever. An abdominal CT scan revealed mild left hydronephrosis and urinalysis identified pyuria. The patient was subsequently admitted to hospital with a diagnosis of complicated pyelonephritis. No recovery was evident after antimicrobial treatment, a repeat CT scan revealed a ureterosciatic hernia. We indwelled a left ureteral stent and repaired the hernia. We did not opt for a surgical approach because of the patient's age and presence of dementia. The stent was removed after 2 months, but the patient was re-admitted 4 months later because of pyelonephritis. Here, we indwelled a left ureteral stent, and the patient underwent regular ureteral stent exchange. Placement of a ureteral stent for ureterosciatic hernia is an effective treatment for elderly patients and those who are poor surgical candidates.
  • Takahiro Isono, Tokuhiro Chano, Tetsuya Yoshida, Ai Makino, Shohei Ishida, Masafumi Suzaki, Susumu Kageyama, Akihiro Kawauchi, Junji Yonese, Takeshi Yuasa
    American journal of cancer research 9 2 415 - 423 2019年 研究論文(学術雑誌) 
    Renal cell carcinoma (RCC) has the high mortality rate among urological malignancies. The development of RCC cannot be effectively reduced by molecular targeted therapies based on nutrient deprivation, such as inhibition of tumor angiogenesis. The objective of this study was to identify predictive biomarkers of poor prognosis and therapeutic molecular targets in patients with RCC. Two independent cohorts were analyzed in the present study. Global transcriptomics were used in the first cohort (43 patients with RCC) to identify biomarker genes. Each identified biomarker was subsequently analyzed using immunohistochemistry in the second cohort (97 patients with RCC). Following transcriptomics, biomarkers were evaluated using receiver operating characteristic curve analysis. Predictive accuracy for poor survivals was assessed using the log-rank test and Cox multivariate analysis. Global transcriptomic analysis in the first cohort focusing on cases with survival periods <2 years after initial diagnosis of metastasis detected seven overexpressed genes, which correlated with poor prognosis. The ADP-ribosylation factor-like 4C (ARL4C) exhibited the best accuracy in the receiver operating characteristic curve analysis and predicted poor survival in the first cohort (log-rank test, P<0.001; Cox multivariate analysis, hazard ratio =167, P=0.005). In the second cohort, the expression of ARL4C was semi-quantitatively evaluated through immunohistochemistry. Twenty-seven cases showed high levels of ARL4C, confirming a significant association with shorter survivals (log-rank test, P<0.001; Cox multivariate analysis, hazard ratio =9.41, P=0.004). ARL4C was shown to be a predictive biomarker for poor prognosis in patients with RCC and may be a novel target in the treatment of RCC.
  • Koki Maeda, Takashi Osafune, Yoshikata Masuda, Takayuki Takeda, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 110 1 36 - 40 2019年 研究論文(学術雑誌) 
    We report a case of drug-induced interstitial lung disease as a result of combined androgen blockade. A 75 year-old male was receiving bicalutamide and reuprorelin acetate treatment for advanced prostate cancer. Two weeks after starting therapy, the patient developed dyspnea due to interstitial lung disease. Based on the clinical diagnosis of drug-induced interstitial lung disease, bicalutamide was withdrawn and steroid therapy was initiated. The patient succumbed 6 days later due to respiratory failure. Drug-induced interstitial lung disease following combined androgen blockade is a rare, but potentially serious adverse effect that requires close attention.
  • Akinori Wada, Tomoya Terashima, Susumu Kageyama, Tetsuya Yoshida, Mitsuhiro Narita, Akihiro Kawauchi, Hideto Kojima
    Molecular Therapy - Oncolytics 12 138 - 146 2019年01月 [有り][無し]
     研究論文(学術雑誌) 
    Selective targeting of drugs to tumor cells is a key goal in oncology. Here, we performed an in vivo phage display to identify peptides that specifically target xenografted prostate cancer cells. This yielded three peptide candidates, LN1 (C-TGTPARQ-C), LN2 (C-KNSMFAT-C), and LN3 (C-TNKHSPK-C); each of these peptides was synthesized and evaluated for binding and biological activity. LN1 showed the highest avidity for LNCaP prostate cancer cells in vitro and was thus administered to tumor-bearing mice to evaluate in vivo binding. Strikingly, LN1 specifically bound to the tumor tissue and exhibited very low reactivity with normal liver and kidney tissues. To demonstrate that LN1 could specifically deliver drugs to prostate cancer tissue, a therapeutic peptide, LN1-KLA (C-TGTPARQ-C-GGG-D[KLAKLAK]2), was prepared and used to treat LNCaP cells in vitro and was also administered to tumor-bearing mice. The therapeutic peptide significantly suppressed growth of the cells both in vitro and in vivo. Our study shows that a selective homing peptide strategy could facilitate cell-specific targeting of therapeutics while avoiding adverse reactions in normal tissues.
  • Satoshi Noda, Tetsuya Yoshida, Daiki Hira, Ryosuke Murai, Keiji Tomita, Teruhiko Tsuru, Susumu Kageyama, Akihiro Kawauchi, Yoshito Ikeda, Shin-ya Morita, Tomohiro Terada
    Clin. Genitourin. Cancer 17 2 e306 - e313 2019年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND: Severe adverse events frequently occur in patients treated with pazopanib, necessitating dose reduction and discontinuation. However, information on the exposure-toxicity relationship is limited. PATIENTS AND METHODS: For this retrospective and observational clinical study, we examined 27 patients with renal cell carcinoma treated with pazopanib and enrolled between October 2014 and March 2018. The primary goal was to evaluate the association between trough pazopanib concentration and occurrence of grade ≥ 3 toxicities, and secondarily, to estimate the association between trough pazopanib concentration and objective response rate. RESULTS: Mean trough pazopanib concentration was significantly higher in the grade ≥ 3 toxicity group (n = 9) than in the grade ≤ 2 toxicity group (n = 18). Based on the receiver operating characteristic curve, the threshold value of trough pazopanib concentration for predicting grade ≥ 3 toxicities was 50.3 μg/mL (area under the curve, 0.85; 95% confidence interval, 0.70-0.99; P < .05). In the pazopanib < 20.5 μg/mL group (n = 3), no patient experienced an objective response. Objective response rates between patients with 20.5 to 50.3 μg/mL pazopanib (n = 11) and patients with ≥ 50.3 μg/mL (n = 13) were similar (45.5% vs. 46.2%). CONCLUSION: From results of this study, the target trough pazopanib concentration range may be 20.5 to 50.3 μg/mL for patients with renal cell carcinoma.
  • 泌尿器科領域におけるReduced Port Surgeryの現状と将来展望 小児泌尿器科領域におけるReduced Port Surgery
    小林 憲市, 上仁 数義, 富田 圭司, 村井 亮介, 水流 輝彦, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏
    日本内視鏡外科学会雑誌 23 7 WS16 - 4 (一社)日本内視鏡外科学会 2018年12月
  • ロボット支援根治的膀胱全摘術(RARC)の初期治療経験
    沖中 勇輝, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏
    日本内視鏡外科学会雑誌 23 7 OS206 - 4 (一社)日本内視鏡外科学会 2018年12月
  • 腹腔鏡下およびロボット支援根治的前立腺全摘除術における膀胱尿道吻合部位置と尿禁制回復
    影山 進, 吉田 哲也, 永澤 誠之, 上仁 数義, 成田 充弘, 河内 明宏
    日本内視鏡外科学会雑誌 23 7 DP136 - 9 (一社)日本内視鏡外科学会 2018年12月
  • ロボット支援腹腔鏡下前立腺全摘除術における神経温存が術後尿禁制に与える影響についての検討
    成田 充弘, 永澤 誠之, 沖中 勇輝, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏
    日本内視鏡外科学会雑誌 23 7 DP137 - 4 (一社)日本内視鏡外科学会 2018年12月
  • 村井 亮介, 吉田 哲也, 成田 充弘, 影山 進, 水流 輝彦, 富田 圭司, 伊狩 亮, 沖中 勇輝, 河内 明宏
    日本老年泌尿器科学会誌 31 80 - 80 日本老年泌尿器科学会 2018年11月
  • 河内 明宏, 上仁 数義, 小林 憲市
    小児科臨床 71 増刊 1989 - 1994 (株)日本小児医事出版社 2018年10月
  • Mohammad Khusni B Ahmat Amin, Akio Shimizu, Dimitar P Zankov, Akira Sato, Souichi Kurita, Masami Ito, Toshinaga Maeda, Tetsuya Yoshida, Tomohisa Sakaue, Shigeki Higashiyama, Akihiro Kawauchi, Hisakazu Ogita
    Oncogene 37 40 5416 - 5434 2018年10月 [有り][無し]
     研究論文(学術雑誌) 
    Tumor metastasis is the most common cause of cancer death. Elucidation of the mechanism of tumor metastasis is therefore important in the development of novel, effective anti-cancer therapies to reduce cancer mortality. Interaction between cancer cells and surrounding stromal cells in the tumor microenvironment is a key factor in tumor metastasis. Using a co-culture assay system with human prostate cancer LNCaP cells and primary human prostate stromal cells, we identified epithelial membrane protein 1 (EMP1) as a gene with elevated expression in the cancer cells. The orthotopic injection of LNCaP cells overexpressing EMP1 (EMP1-LNCaP cells) into the prostate of nude mice induced lymph node and lung metastases, while that of control LNCaP cells did not. EMP1-LNCaP cells had higher cell motility and Rac1 activity than control LNCaP cells. These results were also observed in other lines of cancer cells. We newly identified copine-III as an intracellular binding partner of EMP1. Knockdown of copine-III attenuated the increased cell motility and Rac1 activity in EMP1-LNCaP cells. Reduced cell motility and Rac1 activity following knockdown of copine-III in EMP1-LNCaP cells were recovered by re-expression of wild-type copine-III, but not of a copine-III mutant incapable of interacting with EMP1, suggesting the importance of the EMP1-copine-III interaction. Phosphorylated and activated Src and a Rac guanine nucleotide exchange factor Vav2 were found to be involved in the EMP1-induced enhancement of cell motility and Rac1 activation. Moreover, EMP1 was highly expressed in prostate cancer samples obtained from patients with higher Gleason score. These results demonstrate that upregulation of EMP1 significantly increases cancer cell migration that leads to tumor metastasis, suggesting that EMP1 may play an essential role as a positive regulator of tumor metastasis.
  • Kageyama S, Ii H, Taniguchi K, Kubota S, Yoshida T, Isono T, Chano T, Yoshiya T, Ito K, Yoshiki T, Kawauchi A, Nakata S
    International journal of molecular sciences 19 7 2018年07月 [有り][無し]
     研究論文(学術雑誌) 
    γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers-glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma-and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of cancer cells. It has been demonstrated that the suppression or inhibition of GGCT has an antitumor effect in cancer-bearing xenograft mice. Based on these observations, GGCT is now recognized as a promising therapeutic target in various cancers. This review summarizes recent advances on the mechanisms of the antitumor activity of GGCT inhibition.
  • 下部尿路症状を有する小児患者は、病院と自宅では異なるウロフローを呈する
    中川 翔太, 上仁 数義, 山崎 友莉, 佐藤 亘, 小林 憲市, 河内 明宏
    日本夜尿症学会学術集会プログラム・抄録集 29回 53 - 53 日本夜尿症学会 2018年07月
  • Kim C, Kubota S, Fukuyama K, Omura Y, Hanada E, Kawauchi A
    Hinyokika kiyo. Acta urologica Japonica 64 6 265 - 269 2018年06月 [有り][無し]
  • Susumu Kageyama, Tetsuya Yoshida, Masayuki Nagasawa, Shigehisa Kubota, Keiji Tomita, Kenichi Kobayashi, Ryosuke Murai, Teruhiko Tsuru, Eiki Hanada, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi
    BMC Urology 18 1 52  2018年05月 [有り][無し]
     研究論文(学術雑誌) 
    Background: This study was conducted to determine whether the location of the bladder neck in postoperative cystography predicts recovery of continence after radical prostatectomy. Methods: Between 2008 and 2015, 203 patients who underwent laparoscopic radical prostatectomy (LRP, n = 99) and robot assisted radical prostatectomy (RARP, n = 104) were analyzed. The location of the bladder neck was visualized by postoperative routine cystography, and quantitative evaluation of the bladder neck position was performed according to the bladder neck to pubic symphysis (BNPS) ratio proposed by Olgin et al. (J Endourol, 2014). Recovery of continence was defined as no pad use or one security pad per day. To determine the predictive factors for recovery of continence at 1, 3, 6 and 12 months, several parameters were analyzed using logistic regression analysis, including age (≤68 vs. > 68, BMI (≤23.4 vs. > 23.4 kg/m2), surgical procedure (LRP vs. RARP), prostate volume (≤38 vs. > 38 mL), nerve-sparing technique, vesico-urethral anastomosis leakage, and BNPS ratio (≤0.59 vs. > 0.59). Results: The mean postoperative follow-up was 1131 days (79-2880). At 1, 3, 6 and 12 months after surgery, continence recovery rates were 25, 53, 68 and 81%, respectively. Although older age (> 68) and RARP were significant risk factors for incontinence within 3 months, neither was significant after 6 months. A high BNPS ratio (> 0.59) was the only significant risk factor for the persistence of incontinence at all observation points, up to 12 months. Conclusions: A lower bladder neck position after prostatectomy predicts prolonged incontinence.
  • Masato Baba, Susumu Kageyama, Tetsuya Yoshida, Ryo Fujiwara, Chul Jang Kim, Keita Takimoto, Masayuki Nagasawa, Hiroki Soga, Yukihiro Nagatani, Zenkai Nishikawa, Akihiro Kawauchi
    International Journal of Clinical Oncology 1 - 6 2018年05月 [有り][無し]
     研究論文(学術雑誌) 
    Background: To evaluate the effect of intravesical bacillus Calmette–Guerin (BCG) instillation therapy after second transurethral resection (TUR) on primary T1 bladder cancer. Methods: The subjects were 180 patients diagnosed with T1 bladder cancer at our university and at affiliated hospitals between January 1990 and December 2015. Tumor residual rate, intravesical recurrence rate, and risk factors for intravesical recurrence were investigated. Results: The median follow-up period was 26 (1–175) months. Of the 180 patients, 78 (43%) underwent a second TUR. Residual tumors were detected in 42 patients (53.8%), and no up-staging cases were observed. Within the whole group, 42 patients were treated with intravesical BCG therapy following a second TUR (group 1), 36 were treated with second TUR alone (group 2), 28 were treated with intravesical BCG therapy alone (group 3), and 74 were treated without second TUR or intravesical BCG therapy (group 4). The 1- and 5-year recurrence-free survival rates of the four groups were 80.7 and 59.7% (group 1), 69.0 and 26.3% (group 2), 76.3 and 56.6% (group 3), 64.6 and 48.6% (group 4), respectively. There was no significant difference between group 1 and group 3 (p = 0.401). Intravesical BCG therapy was the only factor preventing intravesical recurrence (p = 0.013). Conclusions: Intravesical BCG therapy alone showed a significant preventive effect with regard to intravesical recurrence. In our cohort, however, second TUR did not improve recurrence-free survival in those individuals who underwent BCG instillation.
  • Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Yonese J, Yuasa T
    Oncotarget 9 33 23091 - 23101 2018年05月 [有り][無し]
     研究論文(学術雑誌) 
    Dormant cancer cells are starvation-resistant leading to problems in the management of cancer. In renal cell carcinomas (RCCs), starvation-resistant cells are resistant to various currently available therapies. However, targeting hypoxia inducible factor 2-alpha (HIF2-alpha) induces cell death in dormantlike/ starvation-resistant RCCs. This study showed that the apoptotic cell death caused by tumor necrosis factor (TNF)-related apoptosis-induced ligand (TNFSF10/ TRAIL) was attenuated by CASP8 and FADD-like apoptosis regulator (CFLAR/c- FLIP) following HIF2-alpha activation, despite the high expression of TRAIL in such RCCs. Knockdowns of TRAIL averted apoptotic cell death caused by HIF2-alpha inhibition in starvation-resistant RCCs. Knockdowns of both HIF2-alpha and c-FLIP augmented apoptotic cell death, whereas overexpression of c-FLIP completely averted apoptosis. In addition, high abundance of TRAIL was correlated with poor prognosis in patients with RCC, suggesting that TRAIL, followed by HIF2-alpha and c-FLIP, play a role in the survival and/or progression of malignant RCCs.
  • Mitsuhiro Narita, Susumu Kageyama, Takatsugu Okegawa, Hidefumi Kinoshita, Fuminori Sato, Ken Nakagawa, Tomonori Habuchi, Akio Hoshi, Akio Matsubara, Koji Yoshimura, Toshiro Terachi, Hiromitsu Mimata, Akihiro Kawauchi
    International Journal of Urology 25 3 263 - 268 2018年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To evaluate the current status of urological laparoendoscopic single-site and reduced port surgery in Japan. Methods: Of the 152 institutions to which councilors of the Japanese Society of Endourology belong, 42 (28%) have carried out laparoendoscopic single-site and reduced port surgery. A total of 32 of these institutions agreed to participate in this survey. Patients who had undergone surgery between January 2008 and March 2014 were included in the present study. Results: Overall, 1145 cases of laparoendoscopic single-site and reduced port surgery were recorded during the study period. The most frequent procedures were adrenalectomy and radical nephrectomy. Laparoendoscopic single-site and reduced port surgery represented 12% (872/7311) of all laparoscopic procedures carried out at participating institutions. The number of patients who underwent pyeloplasty, donor nephrectomy and simple nephrectomy tended to increase, whereas those who underwent adrenalectomy, radical nephrectomy and nephroureterectomy peaked in 2012, and then tended to decrease in 2013. The rates of conversion, perioperative and postoperative complications, were 2.7%, 2.2% and 4.5%, respectively. Conclusions: The number of laparoendoscopic single-site and reduced port urological surgeries in Japan has increased for benign indications, such as pyeloplasty, donor nephrectomy and simple nephrectomy. In contrast, procedures such as adrenalectomy and radical nephrectomy are trending down after reaching a peak in 2012. Overall, laparoendoscopic single-site and reduced port urological surgery in Japan is being safely carried out when compared with other reported series of laparoendoscopic single-site surgery and conventional laparoscopic surgery.
  • Taniguchi K, Matsumura K, Kageyama S, Ii H, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S
    Biochemical and biophysical research communications 496 1 218 - 224 2018年01月 [有り][無し]
     研究論文(学術雑誌) 
    Previous studies show that gamma-glutamylcyclotransferase (GGCT) is expressed at high levels in various cancer tissues and that its knockdown inhibits MCF7 cancer cell growth via upregulation of p21WAF1/CIP1 (p21). However, the detailed underlying mechanism is unclear. Here, we used yeast two-hybrid screening and co-immunoprecipitation to identify Prohibitin-2 (PHB2) as a novel protein that interacts with GGCT. We also show that nuclear expression of PHB2 in MCF7 cells falls upon GGCT knockdown, and that overexpression of PHB2 inhibits p21 upregulation. A chromatin immunoprecipitation assay revealed that nuclear PHB2 proteins bind to the p21 promoter, and that this interaction is abrogated by GGCT knockdown. Moreover, knockdown of PHB2 alone led to significant upregulation of p21 and mimicked the cellular events induced by GGCT depletion, including G0/G1 arrest, cellular senescence, and growth inhibition, in a p21 induction-dependent manner. Taken together, the results indicate that PHB2 plays a central role in p21 upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21.
  • Masugi-Tokita M, Yoshida T, Kageyama S, Kawata M, Kawauchi A
    Journal of neuroendocrinology 2018年01月 [有り][無し]
  • Chul Jang Kim, Tokio Terado, Yukihiro Tambe, Ken-Ichi Mukaisho, Hiroyuki Sugihara, Akihiro Kawauchi, Hirokazu Inoue
    INTERNATIONAL JOURNAL OF ONCOLOGY 52 1 231 - 240 2018年01月 [有り][無し]
     研究論文(学術雑誌) 
    The human cyclin D1 gene generates two major isoforms, cyclin D1a and cyclin D1b, by alternative splicing. Although cyclin D1b mRNA is hardly expressed in normal human tissues, it is detected in approximately 60% of human bladder cancer tissues and cell lines. In the present study, to assess the therapeutic ability of cyclin D1b siRNA, we investigated the anti-oncogenic effects of cyclin D1b siRNA on human bladder cancer cell lines, SBT31A and T24, which express cyclin D1b mRNA. Knockdown of cyclin D1b by specific siRNA significantly suppressed cell proliferation, in vitro cell invasiveness and three-dimensional (3D) spheroid formation in these cell lines. Cell cycle analyses revealed that cyclin D1b siRNA inhibited G1-S transition in T24 cells. The increase in the sub-G1 fraction, morphological aberrant nuclei with nuclear fragmentation and caspase-3 activity in SBA31A cells treated with cyclin D1b siRNA showed that cyclin D1b siRNA induced apoptosis. In T24 cells, knockdown of cyclin D1b suppressed the expression of the stem cell marker CD44. Knockdown of cyclin D1b or CD44 suppressed the invasiveness under 3D spheroid culture conditions and expression of N-cadherin. Tumor growth of SBT31A cells in nude mice was significantly inhibited by cyclin D1b siRNA. Taken together, these results indicate that knockdown of cyclin D1b suppresses the malignant phenotypes of human bladder cancer cells via induction of apoptosis and suppression of cancer cell stemness and epithelial-mesenchymal transition. Applying cyclin D1b siRNA will be a novel therapy for cyclin D1b-expressing bladder cancers.
  • Taniguchi K, Matsumura K, Ii H, Kageyama S, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S
    American journal of cancer research 8 4 650 - 661 2018年 [有り][無し]
     研究論文(学術雑誌) 
    Gamma-glutamylcyclotransferase (GGCT) was originally identified as a protein highly expressed in bladder cancer tissues by proteomic analysis, and its higher expression in a variety of cancers compared to normal tissues have been shown. Depletion of GGCT in various cancer cells results in antiproliferative effects both in vitro and in vivo; thus it is considered a promising therapeutic target. Although it has been shown that knockdown of GGCT induces cellular senescence and non-apoptotic cell death, associated with upregulation of cyclin-dependent kinase inhibitors (CDKIs) including p21WAF1/CIP1, the cellular events that follow GGCT depletion are not fully understood. Here, we show that GGCT depletion induced autophagy in MCF7 breast and PC3 prostate cancer cells. Conversely, overexpression of GGCT in NIH3T3 fibroblast under conditions of serum deprivation inhibited autophagy and increased proliferation. Simultaneous knockdown of autophagy related-protein 5, a critical effector of autophagy, along with GGCT in MCF7 and PC3 cells led to significant attenuation of the multiple cellular responses, including upregulation of CDKIs, increased numbers of senescence-associated β-galactosidase positive senescent cells, and growth inhibition. Furthermore, we show that autophagy-promoting signaling cascades including activation of the AMPK-ULK1 pathway and/or inactivation of the mTORC2-Akt pathway were triggered in GGCT-depleted cells. These results indicate that autophagy plays an important role in the growth inhibition of cancer cells caused by GGCT depletion.
  • Yoshida T, Kageyama S, Isono T, Yuasa T, Kushima R, Kawauchi A, Chano T
    Cancer biomarkers : section A of Disease markers 22 4 755 - 761 2018年 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND AND OBJECTIVE: Renal cell carcinoma (RCC) is the urological malignancy with the highest mortality rate and is increasing in incidence. The prognostic and predictive biomarkers are highly desired. This study aims to investigate the significance of superoxide dismutase 2 (SOD2) as a clinical biomarker in patients with renal cell carcinomas. METHODS: A cohort of 97 patients with RCC was analyzed retrospectively using various clinical parameters and SOD2 expression by immunohistochemistry. RESULTS: Cases with stronger SOD2 positivity of the tumor in comparison to the adjacent normal renal tubule by immunohistochemistry were categorized as high SOD2 and were associated with worse overall survivals (p= 0.005). In particular, in cases with metastatic RCC, high SOD2 expression in the tumors was significantly associated with a worse overall survival (p= 0.001), and the maximum critical risk. Treatment with current molecular targeting therapies did not improve the prognoses of cases with metastatic or recurrent RCC. CONCLUSIONS: High SOD2 expression can be predictive of a poor clinical outcome and be clinically useful in the follow-up of metastatic RCC. Therapeutics for metastatic RCCs require further improvement, such as supplementary administration of agents targeting mitochondrial SOD2.
  • Murai R, Itoh Y, Kageyama S, Nakayama M, Ishigaki H, Teramoto K, Narita M, Yoshida T, Tomita K, Kobayashi KI, Wada A, Nagasawa M, Kubota S, Ogasawara K, Kawauchi A
    PloS one 13 9 e0204745  2018年 [有り][無し]
     研究論文(学術雑誌) 
    Patients with a history of non-muscle-invasive bladder cancer sometimes have recurrence of tumors after transurethral resection of bladder tumor treatment. To find factors related to the recurrence of non-muscle-invasive bladder cancer, we examined tissue specimens taken at transurethral resection of bladder tumor as an initial treatment. We revealed the association between prognosis of non-muscle-invasive bladder cancer and infiltration of Foxp3+ T cells that suppress anti-tumor immunity in 115 primary non-muscle-invasive bladder cancer patients retrospectively identified and followed for at least 3 months after primary transurethral resection. In immunohistological staining, we counted the number of cells positive for CD3 and positive for CD3 and Foxp3 together and calculated the percentage of Foxp3+ T cells among the CD3+ T cells. The recurrence-free survival rate was calculated by the Kaplan-Meier method, and a Cox regression analysis of recurrence factors was performed. The median (interquartile range) percentage of Foxp3+ T cells in all cases was 17.1% (11.9, 11.4-23.3%). Compared by risk stratification, it was 11.4% (10.4, 7.8-18.2%) in the low-risk group (n = 32), 16.8% (12.6, 11.6-24.2%) in the intermediate-risk group (n = 45), and 22.0% (9.7, 16.4-26.1%) in the high-risk group (n = 38). The Kaplan-Meier survival analysis indicated that the Foxp3+ T cell high group (≥ 17.1%) had a worse RFS rate than did the low group (< 17.1%) (P = 0.006). In multivariate analysis, the percentage of Foxp3+ T cells was an independent risk factor for intravesical recurrence (hazard ratio 2.25). Thus, peritumoral Foxp3+ T cell infiltration was correlated to risk stratification and recurrence-free survival. Therefore, the percentage of Foxp3+ T cells in tumor specimens may predict a risk for intravesical recurrence.
  • Yukio Homma, Momokazu Gotoh, Akihiro Kawauchi, Yoshiyuki Kojima, Naoya Masumori, Atsushi Nagai, Tadanori Saitoh, Hideki Sakai, Satoru Takahashi, Osamu Ukimura, Tomonori Yamanishi, Osamu Yokoyama, Masaki Yoshida, Kenji Maeda
    INTERNATIONAL JOURNAL OF UROLOGY 24 10 716 - 729 2017年10月 [有り][無し]
     研究論文(学術雑誌) 
    The present article is the abbreviated English translation of the Japanese guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia updated as of the end of 2016. The target patients are men aged >50 years complaining of lower urinary tract symptoms, with or without benign prostatic hyperplasia, and the target readers are non-urological general physicians and urologists. Mandatory assessment for general physicians is medical history, physical examination, urinalysis and measurement of serum prostate-specific antigen. Additional mandatory assessment for urologists is symptoms and quality of life assessment by questionnaires, uroflowmetry, residual urine measurement, and prostate ultrasonography. Nocturia requires special attention, as it can result from nocturnal polyuria and/or sleep disturbance rather than lower urinary tract disorders. Functional lower urinary tract disorders with or without benign prostatic hyperplasia are primarily managed by conservative therapy and medications, such as (1)-blockers and phosphodiesterase-type 5 inhibitors. Use of other medications or combination pharmacotherapy is to be reserved for urologists. 5-Reductase inhibitors and anticholinergics or 3 agonists are indicated for men with enlarged prostates and overactive bladder symptoms, respectively. Surgical intervention for bladder outlet obstruction is considered for persistent symptoms or benign prostatic hyperplasia-related comorbidities. Surgical modalities should be optimized by the patient's characteristics, performance of equipment and the surgeon's experience.
  • Keiji Tomita, Susumu Kageyama, Eiki Hanada, Tetsuya Yoshida, Yuki Okinaka, Shigehisa Kubota, Masayuki Nagasawa, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi
    UROLOGY 106 221 - 225 2017年08月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVE To study the efficacy of a new laparoscopic varicocelectomy technique using indocyanine green (ICG) angiography. METHODS Laparoendoscopic single-site (LESS) varicocelectomy using ICG angiography was performed in a single institution on 11 patients with a grade 2 or 3 varicocele. Adult men (N = 9, 82%) who were apparently infertile and had a varicocele, as well as prepubertal boys (N = 2, 18%) with testicular growth retardation, underwent a LESS varicocelectomy using ICG angiography. After the separation of testicular veins, arteries, and lymphatics, ICG was injected intravenously, and arterial and venous blood flows were observed by ICG fluorescence. Spermatic veins were cauterized by bipolar forceps and cut. The spermatic artery and lymphatics were preserved. RESULTS The mean time to the arterial phase (AP) from the ICG injection was 34.9 seconds and the mean time to the venous phase was 58.3 seconds. The mean interval from the arterial phase to the venous phase was 23.3 seconds, and in all cases, this time interval facilitated the identification of arteries and veins. The rates of residual varicocele 3 and 6 months after surgery were 9.1% and 0%, respectively. Serious postoperative complications were not observed nor were adverse events induced by ICG. CONCLUSION ICG angiography appears to be safe and appears to facilitate the detection of artery and veins during LESS varicocelectomy. Continuing investigations of efficacy are required of this new and promising procedure in a larger number of patients. (C) 2017 Elsevier Inc.
  • Chul Jang Kim, Yukihiro Tambe, Ken-Ichi Mukaisho, Hiroyuki Sugihara, Susumu Kageyama, Akihiro Kawauchi, Hirokazu Inoue
    ONCOLOGY LETTERS 13 6 4276 - 4284 2017年06月 [有り][無し]
     研究論文(学術雑誌) 
    Periostin is an extracellular matrix protein involved in the regulation of intercellular adhesion. The present study investigated the in vivo tumor suppressor function of periostin in a mouse orthotopic model of bladder cancer. Retroviral vectors were used to transfect human bladder cancer UMUC-3 cell line with periostin. Bladders of nude mice that were transurethrally instilled with periostin-expressing UMUC-3 cells were revealed to weigh less compared with bladders instilled with vector control cells. In total, five (83.3%) of six vector control UMUC-3 bladder tumors exhibited histological evidence of muscle invasion. However, none of the five periostin-expressing UMUC-3 bladder tumors revealed muscle invasion. Thick edematous lesions were present in the submucosa of periostin-expressing UMUC-3 bladder tumors. The expression of periostin also suppressed in vitro cell invasiveness of UMUC-3 cells without affecting cellular proliferation. The level of phosphorylation of phosphoinositide-dependent kinase-1 (PDK1), protein kinase B (Akt) and S6 ribosomal protein, a downstream protein of mammalian target of rapamycin (mTOR) was decreased in periostin-expressing UMUC-3 cells compared with vector control cells. Treatment with 100 ng/ml recombinant human periostin protein also suppressed cell invasiveness and phosphorylation of PDK1, Akt and S6 in UMUC-3 cells, consistent with results using periostin-expressing UMUC-3 cells. Treatment with PDK1, Akt and mTOR inhibitors significantly suppressed UMUC-3 cell invasiveness. These results demonstrate that periostin suppresses in vivo and in vitro invasiveness of bladder cancer via the PDK1/Akt/mTOR signaling pathway. Periostin may be useful as a potent chemotherapeutic agent by suppressing bladder cancer invasiveness.
  • 直腸脱を合併した骨盤臓器脱(腟断端脱、直腸瘤)に対して一期的に腹腔鏡下仙骨腟固定術および直腸固定術を施行した1例
    太田 裕之, 園田 寛道, 清水 智治, 水流 輝彦, 吉田 哲也, 西田 将成, 成田 充弘, 河内 明宏, 植木 智之, 三宅 亨, 生田 大二, 目片 英治, 遠藤 善裕, 谷 眞至
    滋賀医科大学雑誌 30 1 76 - 80 滋賀医科大学雑誌刊行会 2017年05月 [無し][無し]
     
    我々は直腸脱を合併した子宮摘出後の腟断端脱、直腸瘤に対して腹腔鏡下に一期的修復術を施行した1例を経験したので文献的考察を加えて報告する。症例は75歳3回経産婦。会陰部の臓器脱出感を主訴に当院泌尿器科を受診。子宮脱に対して腟式子宮全摘術の既往歴がある。身体所見より膀胱瘤(Stage I)腟断端脱(Stage III)、直腸瘤(Stage II)および直腸脱と診断した。一期的に修復術を行う方針のもと2015年に腹腔鏡下に仙骨腟固定術および直腸固定術を施行した。手順として、まず腟断端周囲を充分に剥離してY字型メッシュを腟に固定しておいた。次いで直腸周囲を充分に剥離した後に仙骨前面に固定した正方形メッシュを直腸後壁に巻き付けて縫合固定した。最後に腟断端をY字型メッシュのアームで牽引して仙骨岬角右側に固定した。手術時間は8時間14分で、出血量は200gであった。術後経過は良好で術後6日に退院した。術後1年半を経過した時点では再発徴候や排泄障害は認めていない。直腸脱を合併した腟断端脱、直腸瘤に対して腹腔鏡下に仙骨腟固定術および直腸固定術を行うことは低侵襲で一期的に修復できる有用な術式であると考えられる。(著者抄録)
  • Koki Maeda, Yusaku Okada, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi
    Acta Urologica Japonica 63 2 75 - 79 2017年02月 [有り][無し]
     研究論文(学術雑誌) 
    An ectopic kidney is a common congenital anomaly of the urogenital system, but malignant tumor in an ectopic kidney has been rarely reported. We report a case of ureteral carcinoma arising from an ectopic kidney in an 83-year-old male. He visited a hospital complaining of gross hematuria. Computed tomography revealed right ectopic kidney, right ureteral tumor and bladder tumor around the right ureteral orifice. Transurethral resection of the bladder tumor was performed and histopathological diagnosis was urothelial carcinoma. He was referred to our clinic for surgery of the right ureteral tumor. We performed open right nephroureterectomy and partial cystectomy. The histopathological diagnosis was a high grade urothelial carcinoma of the right ureter, pT3N0. Four months postoperatively, there was no evidence of recurrence. We discuss the clinical and pathological features of the malignancy in an ectopic kidney.
  • Shang-Jen Chang, Erik Van Laecke, Stuart B. Bauer, Alexander von Gontard, Darius Bagli, Wendy F. Bower, Catherine Renson, Akihiro Kawauchi, Stephen Shei-Dei Yang
    NEUROUROLOGY AND URODYNAMICS 36 1 43 - 50 2017年01月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: This article is a standardization document of the International Children's Continence Society (ICCS); it represent a consensus of ICCS on the management of pediatric daytime urine incontinence (DUI). Materials and Methods: This document was designed and written by a multi-disciplinary core group of authors appointed by the ICCS'board. Results: Based on evidence of studies and the experience of experts, the treatment guideline of DUI is assembled in this standardization document. Guidelines and the algorithm of management include non-pharmacological treatment (urotherapy), as well as the pharmacological therapy and other modalities that are presented for DUI in general, as along with recommendations for individual conditions. Conclusion: The final document is not a systematic literature review. It includes relevant research when available as well as experts' opinion on the current understanding of daytime incontinence in children. This document illustrates that specific treatment of DUI based on an exact diagnosis is effective. The mainstay of treatment is urotherapy, but a combination of treatment modalities is often necessary. (C) 2015 Wiley Periodicals, Inc.
  • Fuminori Sato, Ken Nakagawa, Akihiro Kawauchi, Akio Matsubara, Takatsugu Okegawa, Tomonori Habuchi, Koji Yoshimura, Akio Hoshi, Hidefumi Kinoshita, Akira Miyajima, Yasuyuki Naitoh, Shogo Inoue, Naoshi Itaya, Shintaro Narita, Kazuya Hanai, Kazutoshi Okubo, Masaaki Yanishi, Tadashi Matsuda, Toshiro Terachi, Hiromitsu Mimata
    INTERNATIONAL JOURNAL OF UROLOGY 24 1 69 - 74 2017年01月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To report on a multi-institutional series of non-robotic urological laparoendoscopic single-site surgery in Japan. Methods: Consecutive cases of laparoendoscopic single-site surgery carried out between February 2009 and December 2012 at nine academic institutions were included. We examined the surgical outcomes, including conversion and complications rates. Results: Four hundred and sixty-nine cases were included in the analysis. The most common procedure was adrenalectomy (n = 177) and the second most common procedure was radical nephrectomy (n = 143). The procedures also included nephroureterectomy (n = 40), living donor nephrectomy (n = 40), pyeloplasty (n = 30), urachal remnant excision (n = 9), simple nephrectomy (n = 7), radical prostatectomy (n = 6) and others (n = 17). The access sites included umbilicus (n = 248, 53%) and other sites (n = 221, 47%). A transperitoneal approach was used in 385 cases (82%), and retroperitoneal approach in 84 cases (18%). The median operation time of all procedures was 198 min. Conversion to reduced port surgery, conventional laparoscopy, or open surgery was noted in 27 cases (5.8%), 12 cases (2.6%), and two cases (0.4%), respectively, with an overall conversion rate of 8.7%. Intraoperative complications occurred in 10 cases (2.1%). Post-operative complications were noted in 29 cases (6.2%), including five major complications (1.1%). No mortality was recorded in this series. Conclusions: Non-robotic laparoendoscopic single-site surgery is technically feasible and safe for various urologic diseases in Japan. Furthermore, urological laparoendoscopic single-site surgery is a promising minimally invasive surgical option that is feasible for experienced urological surgeons in intermediate-volume centers as well as high-volume centers.
  • Chul Jang Kim, Yukihiro Tambe, Ken-Ichi Mukaisho, Hiroyuki Sugihara, Akihiro Kawauchi, Hirokazu Inoue
    ONCOLOGY LETTERS 12 6 4850 - 4856 2016年12月 [有り][無し]
     研究論文(学術雑誌) 
    A total of two major isoforms, cyclin Dla and cyclin Dlb, are generated from the human cyclin Dl gene by alternative splicing. Cyclin Dlb is scarcely expressed in normal tissues; however, it is expressed at a high frequency in certain types of cancerous tissue. The present authors previously constructed cyclin Dlb transgenic (Tg) mice and identified rectal tumors, including adenocarcinoma and sessile serrated adenoma, in 62.5% of female Tg mice. In addition, the present authors indicated that cyclin Dlb expression enhances phosphorylation of extracellular signal -regulated kinase (Erk) in these rectal tumors, and in mouse embryonic fibroblast (MEF) cells and human 293T cells. In the present study, it was initially demonstrated that cyclin Dlb has the ability to enhance cell invasiveness by itself; it additionally increases cell invasiveness, anchorage -independent growth and tumorigenicity in cooperation with an activated K-ras oncogene in MEF cells. Phosphorylation of Akt was increased in cyclin Dlb-expressing MEF cells and in the rectal tumor tissues of cyclin Dlb Tg mice. Phosphorylation of Akt was also enhanced by transfection of cyclin Dlb, but not cyclin Dla, in human 293T cells: Treatment with an Akt inhibitor suppressed phosphorylation of Erk in 293T cells expressing cyclin Dlb and D1bTgRT cells established from rectal cancer of the cyclin Dlb Tg mouse. Furthermore, the Akt inhibitor suppressed the invasiveness of D1bTgRT cells and the tumor growth of these cells in nude mice when the Akt inhibitor was injected into the tumors. These results indicate that cyclin Dlb activates Erk through Akt, and that activation of Akt contributes to the tumorigenicity of the cyclin Dlb Tg mice. Inhibitors targeting the phosphoinositide 3-kinase/Akt signaling pathway are thus expected to have therapeutic potential in a variety of human cancer types expressing cyclin Dlb.
  • Matsumura K, Nakata S, Taniguchi K, Ii H, Ashihara E, Kageyama S, Kawauchi A, Yoshiki T
    BMC cancer 16 1 748  2016年09月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Chromosome 7 open reading frame 24 (C7orf24) was originally identified as a highly expressed protein in various types of cancer, and later shown to be a gamma-glutamylcyclotransferase (GGCT). GGCT depletion in cancer cells has anti-proliferative effects in vitro and in vivo, and it is therefore considered a promising candidate as a therapeutic target. However, the cellular events induced by GGCT depletion remain unclear. Methods: GGCT was depleted by siRNA in MCF7, MDA-MB-231, PC3, A172, Hela, and LNCaP cells. Induction of cellular senescence was evaluated with senescence-associated beta-galactosidase (SA-beta-Gal) staining. Expression levels of p21(WAF1/CIP1) and p16(INK4A) were assessed by qRT-PCR and Western blotting. Effects of simultaneous double knockdown of p21(WAF1/CIP1) and p16(INK4A) together with GGCT on cell cycle regulation and cell growth was measured by flow cytometry, and trypan blue dye exclusion test. Results: We found that GGCT knockdown induces significant cellular senescence in various cancer cells. Cyclin dependent kinase inhibitor p21(WAF1/CIP1) and/or p16(INK4A) were upregulated in all cell lines tested. Simultaneous knockdown of p21WAF1/CIP1 recovered the cell cycle arrest, attenuated cellular senescence induction, and rescued the subsequent growth inhibition in GGCT-silenced MCF7 breast cancer cells. In contrast, in GGCT silenced MDA-MB-231 breast cancer cells, GGCT depletion upregulated p16(INK4A), which played a regulatory role in senescence induction, instead of p21(WAF1/CIP1). Conclusions: Our findings demonstrate that induction of cellular senescence mediated by the upregulation of cyclin-dependent kinase inhibitors is a major event underlying the anti-proliferative effect of GGCT depletion in breast cancer cells, highlighting the potential of GGCT blockade as a therapeutic strategy to induce cellular senescence.
  • Ryo Fujiwara, Mitsuhiro Narita, Susumu Kageyama, Akihiro Kawauchi, Takahisa Nakayama, Natsumi Nishi, Hiroyuki Sugihara, Yusaku Okada
    Acta Urologica Japonica 62 9 473 - 477 2016年09月 [有り][無し]
     研究論文(学術雑誌) 
    A 67-year-old man presented at our hospital with severe edema on the left side of his neck, chest and brachial regions. He had a history of right radical nephrectomy due to renal cell carcinoma (RCC, clear cell subtype, stage II) 15 years earlier. Thereafter, metastases to the pancreatic tail and right lung, and left lung metastasis were removed at 8 years and 11 years, respectively, after the nephrectomy. Four years earlier, he had also undergone total gastrectomy for gastric carcinoma (poorly differentiated adenocarcinoma, stage IV) and subsequent maintenance chemotherapy for gastric carcinoma. Follow-up computed tomography (CT) disclosed bilateral lung metastases and a pancreatic head metastasis. Cytology of pleural effusion on admission suggested pleuritis carcinomatosa from RCC. Clinical diagnosis was bilateral lung and pancreatic head metastases, pleuritis carcinomatosa and left subclavian vein thrombosis due to RCC metastasis. Maintenance chemodierapy for gastric carcinoma was replaced by Sunitinib 50 mg for RCC but he died of progressive disease 20 days later. Immunohistochemical study of the tissue from autopsy revealed lung metastasis and pancreatic head metastasis from both RCC and gastric carcinoma as well as multiple visceral metastases, pleuritis carcinomatosa and left subclavian vein thrombosis due to gastric carcinoma. Cause of death was acute respiratory failure due to pulmonary tumor embolism and pulmonary edema. Immunohistochemical study from autopsy was able to reveal the exact diagnosis, and immunohistochemical studies may be helpful in diagnosing die exact origin of metastasis and selecting appropriate treatments in patients with multiple cancers.
  • Terukazu Nakamura, Akihiro Kawauchi, Masakatsu Oishi, Takashi Ueda, Takumi Shiraishi, Hiroyuki Nakanishi, Kazumi Kamoi, Yoshio Naya, Fumiya Hongo, Koji Okihara, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 21 4 791 - 795 2016年08月 [有り][無し]
     研究論文(学術雑誌) 
    To assess the efficacy, outcome and complications of post-chemotherapy laparoscopic retroperitoneal lymph node dissection (L-RPLND) for stage IIA/B testicular germ cell tumor (GCT) patients in comparison with open RPLND (O-RPLND). L-RPLND was performed in 14 patients with stage IIA/B non-seminoma GCTs among 154 non-seminoma patients who received RPLND after completion of chemotherapy with tumor marker normalization at our institution between 1998 and 2013. Their outcomes were compared with those of 14 patients with stage IIA/B non-seminoma GCTs treated with O-RPLND during the same period. Clinical parameters were compared between L-RPLND and O-RPLND. There were no significant differences in the background characteristics of the two groups except for follow-up duration (36 months for L-RPLND, 70 months for O-RPLND; p = 0.02). Blood loss during surgery was significantly less for the L-RPLND group than for the O-RPLND group (155 mL for L-RPLND, 700 mL for O-RPLND; p < 0.001). Parameters related to post-operative recovery were significantly better for the L-RPLND group than for the O-RPLND group. Histopathological examination showed no difference between the two groups. Neither group had disease recurrence. Post-chemotherapy L-RPLND with a bilateral template and nerve-sparing method was safe, effective, and showed a high preservation rate of antegrade ejaculation with no deterioration of outcomes compared to O-RPLND.
  • Satoshi Noda, Daiki Hira, Susumu Kageyama, Fumiyasu Jo, Akinori Wada, Tetsuya Yoshida, Akihiro Kawauchi, Shin-ya Morita, Tomohiro Terada
    CLINICAL GENITOURINARY CANCER 14 4 E453 - E456 2016年08月 [有り][無し]
     研究論文(学術雑誌) 
    Pazopanib, an oral multitargeted tyrosine inhibitor, is approved for the treatment of advanced and/or metastatic renal cell carcinoma (RCC) as the first-line treatment. However, no information is available regarding the dosage adjustment of pazopanib for patients undergoing hemodialysis. Therefore, evaluation of the influence of dialysis treatment on pazopanib pharmacokinetics is needed. We examined the effects of hemodialysis on the pharmacokinetics of pazopanib in a patient with RCC. The patient was a 70-year-old man diagnosed with RCC and undergoing hemodialysis. The patient was treated with pazopanib 400 mg daily. On day 3, pazopanib was discontinued due to hepatic dysfunction. Ten days after the cessation of pazopanib (day 13), he was re-challenged with pazopanib using a 200 mg alternate-day regimen. On day 7 after the re-challenge (day 20), the serum trough concentration of pazopanib was 2915 ng/mL (target concentration: >15,000-20,500 ng/mL), and the patient did not show any severe toxicity. Consequently, the pazopanib dosage was increased to 200 mg daily. There was little difference in the area under the concentration-time curve of pazopanib at 200 mg daily between day 34 (off-hemodialysis) and day 35 (on-hemodialysis). The patient developed grade 1 aspartate aminotransferase elevation on day 60, and the pazopanib treatment was discontinued. We show, for the first time, that the pharmacokinetics of pazopanib are rarely affected by hemodialysis, and that dose adjustment is not necessary. However, this case report refers to only 1 patient undergoing hemodialysis, so further studies are needed. (C) 2016 Elsevier Inc. All rights reserved.
  • Kageyama S, Narita M, Kawauchi A
    Nihon rinsho. Japanese journal of clinical medicine 74 Suppl 3 359 - 362 2016年05月 [有り][無し]
  • Yasuyuki Naitoh, Masakatsu Oishi, Kenichi Kobayashi, Yasuhiro Yamada, Terukazu Nakamura, Kazuyoshi Johnin, Fumiya Hongo, Yoshio Naya, Koji Okihara, Akihiro Kawauchi
    INTERNATIONAL JOURNAL OF UROLOGY 23 4 332 - 336 2016年04月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To evaluate the performance of transvesical laparoscopic surgery for patients with complete double pelvis and ureter. Methods: A total of 10 patients were included in the present study: five had complete double pelvis and ureter with ureterocele (group A), and five did not have ureterocele (group B). Three small incisions of 5 mm were used, without incision in the lower abdomen. In group A patients, the ureterocele wall was resected, and two ureters were sufficiently detached as a combined ureteral complex. Ureterocele on the side of the bladder wall was sutured to the bladder neck, and the bladder wall was strengthened. According to the cross-trigonal technique, ureterocystoneostomy was carried out in two ureters as a combined ureteral complex. In group B patients, two ureters were sufficiently detached, and ureterocystoneostomy was carried out as in group A. Results: In group A, the mean age was 13.4 years (range 2-34 years). The mean operation time was 304.6 min (242-346 min). In group B, the mean age was 16.6 years (range 2-48 years). The mean operation time was 207.8 min (150-249 min). There were no intraoperative and postoperative complications in both study groups. Conclusions: Transvesical laparoscopic surgery can be safely and effectively used in patients with double pelvis and ureter.
  • Keiji Tomita, Hiroyuki Tanaka, Susumu Kageyama, Masayuki Nagasawa, Akinori Wada, Ryosuke Murai, Kenichi Kobayashi, Eiki Hanada, Yasutoshi Agata, Akihiro Kawauchi
    BIOLOGY OF REPRODUCTION 94 2 30  2016年02月 [有り][無し]
     研究論文(学術雑誌) 
    Spermatogenesis is controlled by hormonal secretions from the hypothalamus and pituitary gland, by factors produced locally in the testis, and by direct interaction between germ cells and Sertoli cells in seminiferous tubules. Although the mammalian testis contains high levels of D-aspartate (D-Asp), and D-Asp is known to stimulate the secretion of testosterone in cultured Leydig cells, its role in testis is unclear. We describe here biochemical, immunohistochemical, and flow cytometric studies designed to elucidate developmental changes in testicular D-Asp levels and the direct effect of D-Asp on germ cells. We found that the concentration of D-Asp in mouse testis increased with growth and that fluctuations in D-Asp levels were controlled in part by its degradative enzyme, D-aspartate oxidase expressed in Sertoli cells. In vitro sperm production studies showed that mitosis in premeiotic germ cells was strongly inhibited by the addition of D-Asp to the culture medium. Moreover, immunohistochemical analysis demonstrated that D-Asp accumulated in the differentiated spermatids, indicating either transport of D-Asp to spermatids or its de novo synthesis in these cells. Such compartmentation seems to prevent premeiotic germ cells in mouse testis from being exposed to the excess amount of D-Asp. In concert, our results indicate that in mouse testis, levels of D-Asp are regulated in a spatiotemporal manner and that D-Asp functions as a modulator of spermatogenesis.
  • Yasuhiro Yamada, Yasuyuki Naitoh, Kenichi Kobayashi, Atsuko Fujihara, Kazuyoshi Johnin, Fumiya Hongo, Yoshio Naya, Kazumi Kamoi, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki
    JOURNAL OF ENDOUROLOGY 30 1 24 - 27 2016年01月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Laparoendoscopic single-site surgery (LESS) was performed for 31 cases of pediatric urologic disease in our department. Objective: A retrospective chart review was performed on pediatric patients who underwent LESS. Design, Setting, and Participants: Procedures included pyeloplasty (21), nephrectomy (4), varicocele ligation (3), orchiectomy (1), orchiopexy (1), and removal of female genitalia (1). In all 31 cases, an incision of 15 to 20mm was made in the umbilical region, and a port for LESS was put in place. A 5-mm flexible scope and 5-mm forceps with a bending tip and regular laparoscopic forceps (3, 5mm) were used. Outcome Measurements and Statistical Analysis: Intraoperative and postoperative outcomes were evaluated. Results and Limitations: For the 21 patients with pyeloplasty, the mean operation time was 240 minutes. Postoperative renal pelvis dilatation was relieved in all patients. For the 4 patients with nephrectomy, the mean operation time was 128 minutes. Postoperative urinary incontinence disappeared in all patients. The mean operation time of varicocele ligation was 73 minutes. Postoperation, varicocele disappeared and there was no testicular atrophy. The operation times of orchidectomy, bilateral orchidopexy, and removal of female genitalia mutilation were 60, 170, and 189 minutes, respectively. In all cases, there were no intraoperative or postoperative complications. Conclusions: The advantages of LESS include superior aesthetics with a smaller scar and less pain. LESS is considered as a less burdensome surgery for pediatric patients.
  • Masato Baba, Keiji Tomita, Tetsuya Yoshida, Susumu Kageyama, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi
    Japanese Journal of Urology 107 4 271 - 275 2016年 [有り][無し]
     研究論文(学術雑誌) 
    A 25-year-old man presented complaining of a painful, left scrotal swelling. He first noticed a mass in his left scrotum during childhood, but, in the absence of clinical symptoms, did not seek medical attention. We detected a left testicular tumor which was elastic, firm and smooth. Serum levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and lactate dehydrogenase (LDH) were all within normal range. Magnetic resonance imaging (MRI) and ultrasound revealed a solid tumor with cysts accompanied by intracystic hemorrhage and calcified walls. From the above findings, the tumor was suspected to be benign and, we therefore planned testis-sparing surgery. We performed tumor enucleation under cold ischemia. Since an intraoperative frozen section revealed the tumor to be benign, we preserved the remaining testis as planned. The final pathologic diagnosis was a mature teratoma without a malignant germ cell component. Evidence of recurrence has not been observed five years after the operation. In conclusion, when a mature teratoma that has been present since prepuberty is suspected in an adult, testis-sparing surgery should be considered.
  • Takahiro Isono, Tokuhiro Chano, Tetsuya Yoshida, Susumu Kageyama, Akihiro Kawauchi, Masafumi Suzaki, Takeshi Yuasa
    AMERICAN JOURNAL OF CANCER RESEARCH 6 10 2263 - 2276 2016年 [有り][無し]
     研究論文(学術雑誌) 
    Dormant cancer cells are deprivation-resistant, and cause a number of problems for therapeutic approaches for cancers. Renal cell carcinomas (RCCs) include deprivation-resistant cells that are resistant to various treatments. In this study, the specific characteristics of deprivation-resistant cells were transcriptionally identified by next generation sequencing. The hypoxia-inducible factors (HIF) transcription factor network was significantly enhanced in deprivation-resistant RCCs compared to the sensitive RCCs. Deprivation-resistant RCCs, that had lost Von Hippel-Lindau tumor suppressor expression, expressed hydroxyl-HIF2-alpha in the nucleus, but not sensitiveRCCs. Hydroxyl-HIF-alpha was also expressed in nuclei of RCC tissue samples. Knockdown for HIF2-alpha, but not HIF1-alpha, induced cell death related to a reduction in HIF-related gene expression in deprivation-resistant RCC cells. Chetomin, a nuclear HIF-inhibitor, induced marked level of cytotoxicity in deprivation-resistant cells, similar to the knockdown of HIF2-alpha. Therefore, hydroxyl-HIF2-alpha might be a potential therapeutic target for RCCs.
  • Takuto Kusaba, Takashi Osafune, Masayuki Nagasawa, Toshio Sekioka, Kengo Takimoto, Mitsuhiro Narita, Akihiro Kawauchi
    Japanese Journal of Urology 107 1 39 - 43 2016年01月 [有り][無し]
     研究論文(学術雑誌) 
    Rectourethral fistulais a relatively rare complication of radical prostatectomy but is extremely difficult to treat. We report a case with post-laparoscopic radical prostatectomy rectourethral fistula, treated with only endoscopic shielding. A 75-year-old man had undergone laparoscopic radical prostatectomy for prostate cancer, cT2cN0M0. Although there was no finding of rectal injury during the operation, pneumaturia, pyuria and diarrhea appeared at postoperative day 21 and diagnosed rectourethral fistula by colonoscopy and amidotrizoic acid enema. The fistula did not close spontaneously. Four months after the prostatectomy, we treated with endoscopic shielding by use of polyglycolic acid sheets and fibrin glue. The fistula have not recurred for 20 months after the endoscopic procedure. This method is simple and less-invasive for patients. We think it is worth trying this method before surgical management for narrow rectourethral fistula following radical prostatectomy.
  • Takashi Ueda, Saya Ito, Takumi Shiraishi, Hidefumi Taniguchi, Naruhiro Kayukawa, Hiroyuki Nakanishi, Terukazu Nakamura, Yoshio Naya, Fumiya Hongo, Kazumi Kamoi, Koji Oldhara, Aldhiro Kawauchi, Tsuneharu Miki
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852 11 2467 - 2473 2015年11月 [有り][無し]
     研究論文(学術雑誌) 
    Elucidating the mechanism of prostate cancer cell invasion may lead to the identification of novel therapeutic strategies for its treatment. Paired box 2 (PAX2) and hepatocyte growth factor (HGF) proteins are promoters of prostate cancer cell invasion. We found that PAX2 protein activated the HGF gene promoter through histone H3 acetylation and upregulated HGF gene expression. Deletion analysis revealed that the region from 637 to 314 of the HGF gene was indispensable for HGF promoter activation by PAX2. This region contains consensus PAX2 binding sequences and mutations of the sequences attenuated HGF promoter activation. Using an in vitro invasion model, we found that PAX2 and HGF promoted prostate cancer cell invasion in the same pathway. Knockdown of HGF expression attenuated the cells' invasive capacity. Moreover, in tissue samples of human prostate cancers, HGF and PAX2 expression levels were positively correlated. These results suggested that upregulation of HGF gene expression by PAX2 enhanced the invasive properties of prostate cancer cells. The PAX2/HGF pathway in prostate cancer cells may be a novel therapeutic target in prostate cancer patients. (C) 2015 Elsevier B.V. All rights reserved.
  • Ueda T, Ito S, Shiraishi T, Taniguchi H, Kayukawa N, Nakanishi H, Nakamura T, Naya Y, Hongo F, Kamoi K, Okihara K, Kawauchi A, Miki T
    Biochimica et biophysica acta 1852 11 2467 - 2473 2015年11月 [有り][無し]
  • Koki Maeda, Akinori Wada, Susumu Kageyama, Keita Takimoto, Mitsuhiro Nakita, Akihiro Kawauchi
    Acta Urologica Japonica 61 11 455 - 458 2015年11月 [有り][無し]
     研究論文(学術雑誌) 
    Leiomyoma is a benign smooth muscle tumor which is rarely found in the paraurethral region. We report a case of paraurethral leiomyoma in a 44-year-old female who visited a clinic complaining of urinary retention. Magnetic resonance imaging revealed a 9 cm mass adjacent to the urethra. She was referred to our department. Transvaginal needle biopsy was performed and the histopathological diagnosis was leiomyoma. The mass was completely excised transperitoneally and transvaginally. The resected specimen was 8 × 7 × 4.5 cm in size and 194 g in weight. Histopathological diagnosis was leiomyoma and the tumor cells demonstrated immunoreactivity for estrogen receptors and progesterone receptors. Her postoperative course was uneventful and she gained normal voiding function. In a follow-up after 3 months, there was no evidence of recurrence. We discuss the clinical and pathological features of the paraurethral leiomyoma.
  • Masayuki Nagasawa, Kazuyoshi Johnin, Taichi Sano, Kenichi Kobayashi, Susumu Kageyama, Mitsuhiro Narita, Keisei Okamoto, Akihiro Kawauchi
    Japanese Journal of Urology 106 4 289 - 292 2015年10月 [有り][無し]
     研究論文(学術雑誌) 
    A 6-month-old boy was referred to our hospital with left scrotal swelling. Scrotal ultrasound examination revealed a 2 cm cystic mass without solid component in left testicular parenchyma. Serum AFP, hCG and LDH levels were within normal limits. Although we suspected a simple cyst of the testis or a benign testicular tumor, the left testicle was explored via an inguinal incision in case of malignancy. Since intraoperative frozen section revealed benign, we preserved the remaining testis. The wall of cystic mass had a small solid lesion. The definitive pathological examination of the cyst wall showed mature teratoma including squamous epithelium, glandular epithelium of enteric type and cartilage. At 4 years of follow up, he was free of recurrence without testicular atrophy.
  • Satoshi Noda, Takashi Otsuji, Masato Baba, Tetsuya Yoshida, Susumu Kageyama, Keisei Okamoto, Yusaku Okada, Akihiro Kawauchi, Hiroyuki Onishi, Daiki Hira, Shin-ya Morita, Tomohiro Terada
    CLINICAL GENITOURINARY CANCER 13 4 350 - 358 2015年08月 [有り][無し]
     研究論文(学術雑誌) 
    The benefit of pharmacokinetic assessment of sunitinib remains unknown. We reported that patients with total sunitinib (sunitinib + its active metabolite SU12662) >= 100 ng/mL showed high incidence of Grade >= 3 toxicities and worsening clinical outcomes. Thus, pharmacokinetic assessment of sunitinib could be helpful for dose optimization. Background: Sunitinib has been approved for the treatment of metastatic renal cell carcinoma (RCC). Sunitinib pharmacokinetics shows a large interpatient variability. Patients and Methods: A retrospective, observational clinical study of 21 patients with RCC was performed. Sunitinib was administered for 4 weeks of a 6-week cycle for the first cycle. We evaluated the association of sunitinib-induced toxicities and clinical outcomes with the trough total sunitinib concentration in a steady state during the first cycle. Results: The median total sunitinib concentration was 91.8 ng/mL (range, 49.8-205 ng/mL). There was an association between total sunitinib concentration and the severity of thrombocytopenia, anorexia, and fatigue. Patients with >= 100 ng/mL total sunitinib (n = 8), compared with patients with < 100 ng/mL (n = 13), had a greater incidence of Grade >= 3 toxicities (6 patients [75.0%] vs. 3 patients [23.1%]). Patients with < 100 ng/mL total sunitinib had significantly longer time to treatment failure (TTF) and progression-free survival (PFS) time than patients with >= 100 ng/mL (median TTF, 590 vs. 71 days; P = .04; median PFS, 748 vs. 238 days; P = .02). Conclusion: Results of this study suggest that therapeutic drug monitoring of sunitinib could be useful for avoiding severe toxicities. Dose reduction might be needed, especially when the total sunitinib concentration is >= 100 ng/mL, to avoid unnecessary early discontinuation of treatment.
  • Fumiya Hongo, Akihiro Kawauchi, Takashi Ueda, Atsuko Fujihara-Iwata, Terukazu Nakamura, Yoshio Naya, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 22 8 731 - 734 2015年08月 [有り][無し]
     研究論文(学術雑誌) 
    ObjectivesTo assess the effectiveness of soft coagulation in off-clamp laparoscopic partial nephrectomy. MethodsA total of 32 patients with renal tumors underwent laparoscopic partial nephrectomy with off-clamp using soft coagulation between May 2012 and September 2013. Tumor resection was carried out using a combination of bipolar forceps and a ball electrode using the soft coagulation system without hilar clamping. The outcomes of these patients were compared with those of 30 patients treated with hilar clamping. ResultsThis off-clamp procedure was successfully completed in 31 cases. No significant differences were observed in the mean age (60 vs 61years), sex (male/female; 25/7 vs 20/10), mean RENAL nephrometry score (5.7 vs 5.8), mean body mass index (24.4 vs 23) or tumor size (15mm vs 16mm) between the two groups. No significant differences were noted in positive surgical margins (0 vs 0) or blood loss (104 vs 115cc) as well. In contrast, a significant difference was noted in the total operative time (278 vs 238min). Serum creatinine percentage changes at 3months were 6.4 versus 7.3% in the off-clamp and hilum-clamp groups, respectively, which were not significantly different. ConclusionsOff-clamp laparoscopic partial nephrectomy can be safely carried out by using a soft coagulation technique.
  • Hiroko Kita, Keisei Okamoto, Ryoji Kushima, Akihiro Kawauchi, Tokuhiro Chano
    ONCOLOGY LETTERS 10 2 661 - 666 2015年08月 [有り][無し]
     研究論文(学術雑誌) 
    Dimethyl sulfoxide (DMSO) is an amphipathic molecule that is used as a solvent in biological studies and as a vehicle for drug therapy. The present study was designed to evaluate the potential effects of DMSO as a solvent in the treatment of testicular embryonal carcinomas (ECs). DMSO was applied to two human EC cell lines (NEC8 and NEC14), with the treated cells evaluated in relation to cisplatin (CDDP) resistance, differentiation (using Vimentin, Fibronectin, TRA-1-60, and SSEA-1 and -3 as markers) and stemness (denoted by expression of SOX2 and OCT3/4). Furthermore, DNA methyltransferase (DNMT-1, -3A and -3L) expression and methylation status were analyzed. DMSO induced resistance to CDDP, aberrant differentiation and reduction of stemness-related markers in each of the EC cell lines. The expression levels of DNMT-3L and -3A were reduced in response to DMSO, while this treatment also affected DNA methylation. The data demonstrated that DMSO perturbed differentiation, reduced stemness and induced resistance to CDDP in human EC cells. Therefore, DMSO could reduce drug efficacy against EC cells and its use should be carefully managed in the clinical application of chemotherapy.
  • Susumu Kageyama, Takahiro Isono, Hideaki Iwaki, Eiki Hanada, Keiji Tomita, Tetsuya Yoshida, Tatsuhiro Yoshiki, Akihiro Kawauchi
    INTERNATIONAL JOURNAL OF UROLOGY 22 7 621 - 628 2015年07月 [有り][無し]
     
    In all creatures including humans, the molecules that function in accordance with the genetic code are mainly proteins. After completing the sequencing of the human genome, rapid progress has been made in proteome analysis. The primary structures of almost all proteins were determined by the human genome sequence. However, the whole picture of proteins cannot be elucidated because of alternative splicing and post-translational modifications. Therefore, genomic as well as systematic and comprehensive information of proteins is required. Modern methods of proteomics have dramatically improved the quality and speed of protein analysis. Developments in both bioinformatics and mass spectrometry have contributed to the technical improvement, making it possible to identify proteins in a short time with high accuracy even from a very small sample. In the field of cancer research, many studies of useful diagnostic and prognostic biomarkers using these proteomic technologies have been reported, and target molecules for treatment have been explored. The aim of the present review was to summarize the basic technologies of proteomics and recent research in the field of urothelial cancer obtained using proteomic methods.
  • Ryo Fujiwara, Susumu Kageyama, Keiji Tomita, Eiki Hanada, Teruhiko Tsuru, Tetsuya Yoshida, Mitsuhiro Narita, Takahiro Isono, Akihiro Kawauchi
    Case Reports in Oncology 8 2 339 - 344 2015年05月 [有り][無し]
     研究論文(学術雑誌) 
    A 68-year-old man presented with gross hematuria. A papillary urethral tumor adjacent to the verumontanum was found by cystourethroscopy. Serum prostate-specific antigen (PSA) was 3.246 ng/ml. A transurethral biopsy specimen was most suggestive of a primary urothelial carcinoma of the prostate, for which a radical cystoprostatectomy was performed. The final pathology was prostatic ductal adenocarcinoma with very focal acinar features (Gleason score 5 + 4 = 9, pT3bN0M0). Local recurrence and pelvic bone metastases developed 17 months later, and his PSA rose to 10.806 ng/ml. He was treated with combined androgen blockade and radiation. Two years later, the lesion showed progressive growth. Treatment followed with docetaxel (70 mg/m< sup> 2< /sup> every 3 weeks) and prednisolone 5 mg twice daily. After 10 cycles of chemotherapy, all lesions disappeared and PSA decreased to < 0.005 ng/ml. Three years after chemotherapy, he maintains a complete response without any additional treatments. Docetaxel chemotherapy can be an effective treatment for patients with recurrent prostatic ductal adenocarcinoma.
  • Yoshio Naya, Akihiro Kawauchi, Masakatu Oishi, Takashi Ueda, Atsuko Fujihara, Yasuyuki Naito, Terukazu Nakamura, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 20 2 358 - 361 2015年04月 [有り][無し]
     研究論文(学術雑誌) 
    The aim of this study was to evaluate our institution's experience in performing laparoscopic radical nephrectomy (LRN) and partial nephrectomy (PN) in patients with small renal masses. 142 patients with cT1aN0M0 lesions were identified. 68 of these subjects were treated with LRN and 74 were treated with laparoscopic PN (LPN). The clinicopathological characteristics of the two groups of patients, including diameter-axial-polar (DAP) nephrometry and RENAL nephrometry score (RENAL-NS), operative results, and outcomes, were retrospectively analyzed. A multivariate logistic regression analysis for the selection of PN as the treatment showed that tumor size, DAP nephrometry, RENAL-NS and imperative condition were all independent factors. The area under the curve receiver operating characteristics (ROC-AUC) of DAP and RENAL-NS for performing LPN were 0.897 and 0.825, respectively. Although LRN was performed in patients with a high nephrometry score in this study, open partial nephrectomy (OPN) should be considered for patients with a high nephrometry score in T1a renal cell carcinoma (RCC) because of better functional and similar oncological outcomes. Based on ROC analysis, when DAP is 6 or less, LPN should be considered and when DAP is 7 or more, OPN should be considered.
  • Masayuki Nagasawa, Kazuyoshi Johnin, Eiki Hanada, Tetsuya Yoshida, Keisei Okamoto, Yusaku Okada, Tomoko Ueba, Takashi Taga, Shigeru Ohta, Akihiro Kawauchi
    UROLOGY 85 3 671 - 673 2015年03月 [有り][無し]
     研究論文(学術雑誌) 
    We report a case of advanced childhood testicular yolk sac tumor with bone metastasis, which was successfully treated by multimodal treatment. Optimal management of bone metastases from testicular yolk sac tumor in childhood is discussed. (C) 2015 Elsevier Inc.
  • Susumu Kageyama, Eiki Hanada, Hiromi Ii, Keiji Tomita, Tatsuhiro Yoshiki, Akihiro Kawauchi
    BIOMED RESEARCH INTERNATIONAL 2015 345219  2015年 [有り][無し]
     
    Gamma-glutamylcyclotransferase (GGCT) is one of the major enzymes involved in glutathione metabolism. However, its gene locus was unknown for many years. Recently, the gene for GGCT was found to be identical to C7orf24, which is registered as a hypothetical protein. Orthologs have been found in bacteria, plants, and nematodes as well as higher organisms, and the GGCT gene is highly preserved among a wide range of species. GGCT (C7orf24) was also reported as an upregulated protein in various cancers. Although the function of GGCT in cancer cells has not been determined, the following important activities have been reported: (1) high expression in various cancer tissues and cancer cell lines, (2) low expression in normal tissues, (3) inhibition of cancer cell proliferation via anti-GGCT RNAi, (4) inhibition of cancer cell invasion and migration via anti-GGCT RNAi, (5) an epigenetic transcriptional regulation in cancer cells, and (6) an antitumor effect in cancer-bearing xenograft mice. Therefore, GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings.
  • Tadashi Matsuda, Hiroomi Kanayama, Yoshinari Ono, Akihiro Kawauchi, Hiroaki Mizoguchi, Ken Nakagawa, Masatsugu Iwamura, Masanobu Shigeta, Tomonori Habuchi, Toshiro Terachi
    JOURNAL OF ENDOUROLOGY 28 11 1374 - 1378 2014年11月 [有り][無し]
     研究論文(学術雑誌) 
    Background and Purpose: The Japanese Urological Association and Japanese Society of Endourology established a urologic laparoscopic skills qualification system called the Endoscopic Surgical Skill Qualification (ESSQ) System in Urological Laparoscopy in 2004. The reliability of video assessments by referees was evaluated. Materials and Methods: Videos of nephrectomies or adrenalectomies performed by the applicants were assessed by two referees selected among a pool of 42 referees. From 2004 to 2011, 1308 urologists applied and 60.2% were qualified after video assessments. The results of skills assessments on 1220 videos that had fixed points by two referees were analyzed statistically. Results: The average number of videos that each referee assessed was 58.1, with a range of 16 to 87. The accordance rate of the results of the video assessment, pass or fail, by the two referees was 68.9%. The scores of the video assessment by each referee averaged 62.7 +/- 2.4 (standard deviation) (full score was set at 75 points and >= 60 points was needed to pass). There was a statistically significant difference in the average video assessment score among the referees (P<0.001), and five referees showed significantly higher or lower average scores than the other referees. The percentage qualification of the final decision made by the Referee Committee on the videos originally assessed by each referee showed no significant differences among the 42 referees. The accordance rate of the results from the video assessment by each referee with the final decision by the committee showed a statistically significant positive correlation with the number of videos assessed by each referee (r=0.404, P=0.0080). Conclusions: The ESSQ system showed moderate reliability for the video assessments by the referees. It was concluded that the video assessments by the referees were fair for all applicants, because the final qualification rates showed no significant differences among the referees.
  • Fumiya Hongo, Akihiro Kawauchi, Yoshizo Itoh, Hidetaka Fujii, Yasuyuki Naitoh, Terukazu Nakamura, Yoshio Naya, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki
    JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES 24 11 795 - 798 2014年11月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To evaluate the feasibility of regional cramp in laparoscopic partial nephrectomy, we performed partial nephrectomy using a kidney grasper that enabled the application of ischemia to a limited region of the kidney. Materials and Methods: The subjects were 5 renal cell carcinoma patients. The mean tumor diameter was 15 mm. There were 2 male and 3 female patients. A transperitoneal approach was used in all cases. Following the standard procedure of laparoscopic partial resection, the hilum of the kidney was confirmed and treated to prepare for rapidly applying clamping with forceps. Tumor resection and suture were then performed under partial warm ischemia using a kidney grasper. Results: Surgery could be completed in 4 patients using this method. In the remaining patient, control of bleeding was considered difficult during tumor resection after applying partial ischemia, and so the procedure was switched to renal artery clamping using bulldog forceps. In the 4 patients in whom a kidney grasper was used, the mean partial warm ischemia time was 23.6 minutes (range, 23-25 minutes), and the mean blood loss was 110 mL (range, 20-260 mL). Conclusions: This procedure may be a useful option in ischemia for partial nephrectomy.
  • Saya Ito, Takashi Ueda, Akihisa Ueno, Hideo Nakagawa, Hidefumi Taniguchi, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki
    FEBS JOURNAL 281 19 4506 - 4518 2014年10月 [有り][無し]
     研究論文(学術雑誌) 
    Androgen-independent prostate cancer is known as a hormone-refractory disease. Although the androgen receptor (AR) is considered to be a key regulator of androgen-independent prostate cancer progression, the mechanism through which AR gene expression is regulated is not well understood. In the present study, we showed that the AR gene was upregulated by paired box 2 (PAX2) in androgen-independent prostate cancer. When PAX2 upregulated AR gene expression, a decrease in DNA methylation of the AR gene locus was also observed. PAX2 was highly expressed and promoted cell growth in an androgen-independent prostate cancer cell line (22Rv1). The cell growth inhibition by PAX2 knockdown was rescued by AR overexpression in 22Rv1 cells. In a mouse xenograft model of androgen-independent prostate cancer, PAX2 knockdown inhibited tumor growth and AR gene expression and also increased DNA methylation of the AR gene. Consistent with this, AR and PAX2 expression levels were positively correlated in prostate cancer patients. These findings suggested that PAX2 promoted cancer cell growth in androgen-independent prostate cancer by regulating AR gene expression through an epigenetic mechanism.
  • Yasuyuki Naitoh, Akihiro Kawauchi, Yasuhiro Yamada, Atsuko Fujihara, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 21 8 793 - 796 2014年08月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To compare the outcomes of laparoendoscopic single-site pyeloplasty versus those of conventional laparoscopic pyeloplasty. Methods: A total of 26 laparoendoscopic single-site pyeloplasty cases carried out in University Hospital: Kyoto Prefectural University of Medicine, Kyoto, Japan, from 2008 to 2013 were compared with a control group of 26 age-matched laparoscopic pyeloplasty cases carried out during the same study period. Results: The mean age of the patients was 20.4 years (range 1-56 years). Laparoendoscopic single-site pyeloplasty was carried out on the right in nine cases and on the left in 17 cases. The operative time was 246 +/- 68 min. Regarding the 14 pediatric patients, the mean age was 7.1 years (range 1-14 years). The operative time was 243 +/- 49 min. As for the 12 adult patients, the mean age was 35.8 years (range 16-56 years). The operative time was 248 +/- 86 min. The mean operative time of the control group in age-matched laparoscopic pyeloplasty was 239 +/- 51 min. Times were 229 +/- 54 min for the pediatric patients and 253 +/- 45 min for the adult patients. There was no significant difference in the operative time between the control group and the laparoendoscopic single-site group for both adults and children. Blood loss was minimal, and no intraoperative and postoperative complications were observed in the 26 laparoendoscopic single-site pyeloplasty cases. Conclusion: The present findings suggest that laparoendoscopic single-site pyeloplasty can be used in both pediatric and adult patients, offering a superior cosmetic outcome than conventional laparoscopic pyeloplasty, and a lower degree of postoperative pain. A large-scale prospective, randomized study is required to confirm these findings, and to define the future role of laparoendoscopic single-site pyeloplasty.
  • Koji Okihara, Kana Kobayashi, Tsuyoshi Iwata, Yasuyuki Naitoh, Kazumi Kamoi, Akihiro Kawauchi, Kei Yamada, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 21 3 271 - 276 2014年03月 [有り][無し]
     研究論文(学術雑誌) 
    ObjectivesTo evaluate the outcome of low-dose-rate permanent brachytherapy combined with anti-androgen deprivation therapy for intermediate-risk prostate cancer excluding biopsy Gleason score 4+3. MethodsPatients included in the intermediate-risk group were those presenting clinical stage T1c to T2c (by magnetic resonance imaging staging), Gleason score 3+4 or lower and/or prostate-specific antigen less than 20ng/mL, whereas those with clinical stage T1c to T2a, Gleason score 3+3 and prostate-specific antigen less than 10ng/mL represented the low-risk group, and were used as controls. In the intermediate-risk group, therapy with a luteinizing hormone-releasing hormone analog was continued for at least 6 months before and after permanent brachytherapy. ResultsA total of 147 low-risk group patients and 139 intermediate-risk group patients were included in the study. The median follow up was 51 and 52 months for the intermediate-risk group and low-risk group, respectively. The 5-year overall, cause-specific and distant-metastasis-free survival rates in the low-risk group and intermediate-risk group were 97.6/99.2, 100/100 and 100/100%, respectively. The 5-year biochemical disease-free survival in these groups were 95.9 and 92.5%, respectively (P=0.18). There was no sexual activity and desire for erection before treatment in 50%, and in 46% of the patients in the low-risk group and intermediate-risk group, respectively. Overall satisfaction score at 2 years after permanent brachytherapy significantly improved, compared with pretreatment (P=0.0399). ConclusionsIn intermediate-risk prostate cancer, excluding biopsy Gleason score 4+3, permanent brachytherapy combined with androgen deprivation therapy for 6 months or more represents an effective treatment option in Japanese patients, based on a favorable prognosis, adverse event profile and quality of life analysis.
  • Yasuyuki Naitoh, Akihiro Kawauchi, Kazumi Kamoi, Jintetsu Soh, Fumiya Hongo, Koji Okihara, Tsuneharu Miki
    UROLOGY 83 1 243 - 246 2014年01月 [有り][無し]
     研究論文(学術雑誌) 
    INTRODUCTION The objective of the present study was to evaluate the results of laparoendoscopic single-site (LESS) pyeloplasty and pyelolithotomy, which were performed concurrently in patients with pelviureteric junction obstruction (PUJO) and renal stones. TECHNICAL CONSIDERATIONS Four patients with PUJO and renal stones underwent pyelolithotomy performed concurrently with LESS pyeloplasty. In 3 patients, a 2.5-cm incision was made in the umbilical region. In the fourth patient, the 2.5-cm vertical incision was made at a site 7 cm below the umbilical region because of a stone in the right lower calyx. After dissection of the pelviureteric junction, an incision of approximately 1 cm was made along the presumed transection line of the renal pelvis. The pyelolithotomy was performed using a 24F rigid nephroscope through a SILS port. Dismembered pyeloplasty was performed after extraction of the renal stones was completed. The mean operation time was 277 minutes (range, 225-373), and the mean lithotomy time was 31 minutes (range, 20-50). No intraoperative or postoperative complications were observed. For all 4 patients, discharge from the hospital was possible after a mean of 3.4 postoperative days (range, 3-4). All patients became stone free. Postoperative ultrasound revealed that hydronephrosis improved in all patients. In all patients, resolution of the symptoms was confirmed. CONCLUSION LESS nephrolithotomy with pyeloplasty is a safe and effective procedure with a good cosmetic result for patients with PUJO and renal stones. UROLOGY 83: 243-246, 2014. (C) 2014 Elsevier Inc.
  • Maeda K, Kojima F, Ishida M, Iwai M, Kagotani A, Kawauchi A
    International journal of clinical and experimental pathology 7 7 4408 - 4414 2014年 [有り][無し]
     
    Mullerianosis of the urinary bladder is an extremely rare benign condition, characterized by the presence of a mixture of at least two mullerian-derived components, and endosalpingiosis is also an extremely rare condition, characterized by the presence of tubal-type epithelium. In this report, we describe the 17th case of mullerianosis and 5th case of endosalpingiosis of the urinary bladder. A 39-year-old Japanese female presented with menstrual hematuria and was found to have a polypoid lesion in the posterior wall of the urinary bladder. Histopathological study demonstrated variably-sized dilated tubular glands in the lamina propria and muscularis propria. These dilated glands were covered by ciliated cuboidal cells, and some of them were covered by columnar cells with intracytoplasmic mucin. Moreover, a tiny focus of endometrial tissues was also present. Immunohistochemically, these glandular cells were positive for estrogen receptor. Accordingly, a diagnosis of mullerianosis was made. The second case was a 37-year-old Japanese female, who was found to have a polypoid lesion in the posterior wall of the bladder. Dilated tubular glands were covered by ciliated cells in the lamina propria and muscularis propria. Neither endocervical nor endometrial tissues were observed. Immunohistochemically, these ciliated cells were positive for estrogen receptor. Accordingly, a diagnosis of endosalpingiosis was made. Our analysis revealed that these two conditions mainly affect premenopausal females and occur exclusively in the posterior wall. Although the pathogenesis remains completely unresolved, a metaplastic theory is favored. The recognition of these two conditions is important because they can mimic invasive adenocarcinoma.
  • Atsuko Fujihara, Osamu Ukimura, Hisashi Honjo, Tsuyoshi Iwata, Takeshi Ueda, Toru Matsugasumi, Kazumi Kamoi, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki
    JOURNAL OF UROLOGY 189 5 1797 - 1803 2013年05月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: By analyzing bladder diaries with patient self-reported urinary perception grades, we developed the urge perception index, a quantitative measure of bladder hypersensitivity. We evaluated the impact of the urge perception index on the definition of overactive bladder severity. Materials and Methods: We retrospectively evaluated the records of 69 female patients who visited our outpatient clinic with the complaint of storage symptoms. Patients were asked to complete the overactive bladder symptom score and a 3-day bladder diary with self-reported grading of urinary perception on a range of 1 to 5 per void. Overactive bladder was diagnosed in 43 patients and nonoveractive bladder was diagnosed in 26. The urge perception index was defined as voided volume divided by the urinary perception grade at each void. Results: We analyzed 1,578 reported voids. According to the urinary perception grade, urge perception index values for overactive bladder were significantly lower than those for nonoveractive bladder (grades 1 to 4 p <0.001). The average +/- SD urge perception index in 3-day bladder diaries was lower in overactive than in nonoveractive bladder cases (55 +/- 28 vs 133 +/- 73, p <0.0001). The most severe (lowest) single urge perception index value during the 3 days was significantly lower in patients with overactive than with nonoveractive bladder (mean 20 +/- 12 vs 62 +/- 40, p <0.0001). There were negative linear correlations of the urge perception index with total overactive bladder symptom scores (r = -0.598, p <0.0001) and with an urgency symptom score (r = -0.557, p <0.0001). Conclusions: The urge perception index, an integrated parameter of patient reported bladder perception and voided volume, could be promising to quantify the severity of overactive bladder or bladder hypersensitivity by bladder diary analysis.
  • Yasuyuki Naitoh, Akihiro Kawauchi, Kazumi Kamoi, Jintetsu Soh, Koji Okihara, Suong-Hyu Hyon, Tsuneharu Miki
    Urology 81 5 1095 - 1100 2013年05月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To evaluate the hemostatic effect of newly developed medical adhesive in animal partial nephrectomy models. Materials and Methods: A total of 30 experimental rabbits were used in the first study. After clamping the renal vessels, partial nephrectomy was performed up to the opening of the calices. Bioglue was applied to the resection stumps using the new glue (group 1, n = 10) or fibrin glue (group 2, n = 10) for 2 minutes, and the blood loss was measured after unclamping the vessels. Simple unclamping without glue (group 3, n = 10) was also evaluated. For the second study, we used 9 dogs with blood pressure monitoring. After preparation similar to that for the first study, the new glue was applied in 3 dogs (group 4), fibrin glue in 3 dogs (group 5) and no glue in 3 dogs (group 6). Histologic evaluation was performed at 7 days and 1 month after surgery. Results: The mean blood loss was significantly less in group 1 (1.45 g) than in groups 2 (6.59 g) and 3 (19.77 g P < .001 for both). It was also significantly less in group 4 (12.5 g) than in group 5 (182.5 g P < .001). Group 4 maintained their initial blood pressure throughout the study, but a significant decrease was observed in group 5. No hematoma was observed at day 7. Conclusion: The new glue showed acceptable hemostasis when applied to the resection stumps after partial nephrectomy in both the rabbit and the dog models. These findings indicate that it could be useful for hemostasis after partial nephrectomy. © 2013 Elsevier Inc. All Rights Reserved.
  • Hirokazu Ishida, Tomohito Yagi, Masami Tanaka, Yuichi Tokuda, Kazumi Kamoi, Fumiya Hongo, Aldhiro Kawauchi, Masakazu Nakano, Tsuneharu Miki, Kei Tashiro
    GENE 516 1 33 - 38 2013年03月 [有り][無し]
     研究論文(学術雑誌) 
    When the whole human genome sequence was determined by the Human Genome Project, the number of identified genes was fewer than expected. However, recent studies suggest that undiscovered transcripts still exist in the human genome. Furthermore, a new technology, the DNA microarray, which can simultaneously characterize huge amounts of genome sequence data, has become a useful tool for analyzing genetic changes in various diseases. A version of this tool, the tiling DNA microarray, was designed to search all the transcripts of the entire human genome, and provides huge amounts of data, including both exon and intron sequences, by a simple process. Although some previous studies using tiling DNA microarray analysis have indicated that numerous novel transcripts can be found in the human genome, none of them has reported any novel full-length human genes. Here, to find novel genes, we analyzed all the transcripts expressed in normal human prostate cells using this microarray. Because the optimal analytical parameters for using tiling DNA microarray data for this purpose had not been established, we established parameters for extracting the most likely regions for novel transcripts. The three parameters we optimized were the threshold for positive signal intensity, the Max gap, and the Min run, which we set to detect all transcriptional regions that were above the average length of known exons and had a signal intensity in the top 5%. We succeeded in obtaining the full-length sequence of one novel gene, located on chromosome 12q24.13. We named the novel gene "POTAGE". Its 5841-bp mRNA consists of 26 exons. We detected part of exon 2 in the tiling data analysis. The full-length sequence was then obtained by RT-PCR and RACE. Although the function of POTAGE is unclear, its sequence showed high homology with genes in other species, suggesting it might have an important or essential function. This study demonstrates that the tiling DNA microarray can be useful for identifying novel human genes. (C) 2012 Elsevier B.V. All rights reserved.
  • Toiyama D, Takaha N, Shinnoh M, Ueda T, Kimura Y, Nakamura T, Hongo F, Mikami K, Kamoi K, Kawauchi A, Miki T
    Molecular and clinical oncology 1 1 69 - 74 2013年01月 [有り][無し]
     研究論文(学術雑誌) 
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is endogenously expressed in immune cells and contributes to immunosurveillance for cancer. TRAIL induces apoptosis preferentially in various cancer cells, including renal cell carcinoma (RCC) cells. In this study, the serum TRAIL level was examined using an enzyme-linked immunosorbent assay in 52 healthy controls and in 84 RCC patients prior to surgery and its significance as a biomarker was evaluated. The median serum TRAIL level was lower in RCC patients compared to the healthy controls (55.9 vs. 103.1 pg/ml; P=0.019). RCC with lymph node metastasis (N1-2), distant metastasis (M1), stage III-IV, or microscopic venous invasion was associated with decreased serum TRAIL levels (P=0.032, 0.067, 0.020 and 0.011). When comparing serum TRAIL levels in the same RCC patients prior and subsequent to surgery (n=11), the levels were significantly higher after surgery (P=0.031). The cause-specific survival rate was significantly higher in RCC patients with high serum TRAIL levels compared to those with low serum TRAIL levels (P=0.0451). TRAIL was estimated to contribute 64 and 13% of the lymphocyte-mediated cytotoxicity against human RCC ACHN and Caki-1 cells, respectively. These data suggest that the serum TRAIL level may be useful as a prognostic biomarker in RCC patients.
  • Koji Okihara, Kazuya Mikami, Kazumi Kamoi, Koji Kitamura, Akihiro Kawauchi, Tsuneharu Miki
    Urologia Internationalis 91 1 49 - 54 2013年 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: The aim of this study was to assess the screenees' knowledge on prostate cancer and attitude to PSA screening using the Fact Sheet from one district, Kyoto, Japan. Methods: A PSA screening program is offered to people aged more than 54 years since 1995. The Fact Sheet consists of several chapters, as follows: (1) possibility of diagnosing prostate cancer in terms of the PSA threshold, and future morbid risk, (2) benefit and harm of biopsy, (3) necessary examinations after the diagnosis of prostate cancer and risk for overdiagnosis and overtreatment, and (4) comorbidity of main treatments such as surgery and radiation therapy. Each screenee was asked how well the Fact Sheet was understood. Results: Of the 330 men, 288 read the Fact Sheet for the first time. Of those, 59 and 75% did not know that biopsy indication was determined based on the PSA value and the concept of overdiagnosis, respectively. Furthermore, 68% did not know that active surveillance is established as one option for prostate cancer treatment. However, the screenee's knowledge in the 42 men who read the Fact Sheet previously improved substantially. Conclusions: The degree of comprehension of examinees is currently insufficient, and repeated enlightenment is required.
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintetsu Soh, Kazumi Kamoi, Tsuneharu Miki
    JOURNAL OF UROLOGY 188 5 1910 - 1914 2012年11月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: There have been few reports addressing how nocturnal enuresis affects the health related quality of life of patients and their mothers. Thus, we evaluated the health related quality of life of enuretic children and their mothers. Materials and Methods: The health related quality of life of 139 patients with nocturnal enuresis and that of their mothers were evaluated before and after treatment. The children's health related quality of life was evaluated with the Kid-KINDL (R) protocol. The mothers' health related quality of life was evaluated using the SF-36 (R), the SDS (Self-Rating Depression Scale) for rating depression and the STAI (State-Trait Anxiety Inventory) for assessing anxiety. Results: In the health related quality of life of enuretic children, the family domain score was significantly lower than that of controls (p = 0.02). In the health related quality of life of the mothers as shown by SF-36, the vitality domain score was significantly lower compared to controls (p = 0.01). The evaluation of the STAI score demonstrated a higher state anxiety score (p = 0.003), which represents current suffering from anxiety, and a similar trait anxiety score (p = 0.22), which represents a similar level of underlying tendency to anxiety. There was no significant difference between the mothers of enuretic children and the controls in the SDS evaluation. After treatment for enuresis the health related quality of life score was improved not only for the enuretic children as assessed by the Kid-KINDL protocol, but also for the mothers of enuretic children as assessed by the SF-36 and STAI. Conclusions: Similar to other pediatric chronic diseases, nocturnal enuresis is a condition that negatively affects the health related quality of life of children and their mothers. Impaired health related quality of life can be improved after the successful treatment of nocturnal enuresis.
  • Yves Homsy
    JOURNAL OF UROLOGY 188 5 1914 - 1914 2012年11月 [有り][無し]
  • Naoki Hirahara, Osamu Ukimura, Issei Hayashi, Kazumi Kamoi, Akihiro Kawauchi, Minoru Matsui, Tsuneharu Miki
    ULTRASOUND IN MEDICINE AND BIOLOGY 38 8 1357 - 1362 2012年08月 [有り][無し]
     研究論文(学術雑誌) 
    The aim of this study was to develop a novel technique for a minimally invasive ultrasound measurement of postvoid residual urine (PVR) in conscious mice using a miniature ultrasound probe and a transrectal approach. The PVR was determined by the ellipsoid formula in the maximum sectional image of the bladder visualized with a 20-MHz ultrasound probe (2 mm in diameter) inserted into the rectum. The accuracy, including the intra-and interobserver reproducibilities, of the ultrasonic PVR measurements (in 10 5- to 50-week-old mice) was evaluated, which revealed excellent internal consistency. In M-3 muscarinic acetylcholine receptor knockout male mice, a chronological evaluation of the PVR identified abnormal urinary retention present at infancy and exacerbated with aging, suggesting significant voiding dysfunction. Our technique for the measurement of PVR in conscious mice was accurate and useful for identifying the voiding dysfunction in mice. (E-mail: naoki-h@koto.kpu-m.ac.jp) (C) 2012 World Federation for Ultrasound in Medicine & Biology.
  • Koji Okihara, Osamu Ukimura, Soh Ushijima, Kazumi Kamoi, Tsuyoshi Iwata, Kana Kobayashi, Yasuyuki Naitoh, Hideya Yamazaki, Akihiro Kawauchi, Tsuneharu Miki
    BRACHYTHERAPY 11 4 265 - 270 2012年07月 [有り][無し]
     研究論文(学術雑誌) 
    PURPOSE: A previous study showed that a visual analog scale (VAS) that measures quality of life (QOL) in relation to each of the seven items on the International Prostate Symptom Score (IPSS) was found to be significantly more able to identify a patient's chief complaint. The aim of this study was to assess the two questionnaires with special reference to the symptom that the patient most wants treated via the concomitant use of the IPSS and VAS after permanent brachytherapy (PBT). METHODS AND MATERIALS: A total of 156 men undergoing PBT were enrolled. The IPSS and VAS were evaluated at the preimplantation stage and at 1-3 months, 6-9 months, and 1 year after PBT. The correlations between the IPSS-QOL score and the total for the 14 symptoms questions included in the IPSS and VAS were statistically calculated. Multivariate analysis was used to investigate which factors could be used to predict the IPSS-QOL after PBT. RESULTS: The correlation coefficients between the IPSS-QOL score and the seven questions on the VAS were higher than those between the IPSS-QOL and the seven questions on the IPSS. Multivariate analysis showed that the strongest factor for determining IPSS-QOL at each time point was nocturia on the VAS. CONCLUSIONS: The VAS scale reflected the change in the patients' QOL more precisely than the IPSS, which examines the frequency of lower urinary tract symptoms. Nocturia plays a key role in determining QOL. VAS could be a promising tool for assessing satisfaction in patients with lower urinary tract symptoms after PBT. (C) 2012 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
  • Ichiro Takeuchi, Natsuki Takaha, Terukazu Nakamura, Fumiya Hongo, Kazuya Mikami, Kazumi Kamoi, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki
    PROSTATE 72 10 1124 - 1132 2012年07月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND We previously reported that the level of high mobility group protein AT-hook 1 (HMGA1) is low in androgen-dependent prostate cancer (PCa) cells (LNCaP), but is high in androgen-independent PCa cells (DU145 and PC-3) and that HMGA1 is a strong candidate gene playing a potential role in the progression of PCa. These findings have prompted us to evaluate the effect of HMGA1 on developing androgen independency, which is associated with the progression of PCa. METHODS Expression of HMGA1 in PCa cells and mouse tissues was examined by Western blot. In order to examine the effect of HMGA1 on cell growth under androgen-deprived condition, we transfected HMGA1 into LNCaP cells, and siRNA into both DU145 and PC-3 cells, respectively. RESULTS Androgen-deprivation induced an increase in the level of HMGA1 in LNCaP cells in vitro and in vivo, but did not in normal prostate tissue. Overexpression of HMGA1 maintained the cell growth of LNCaP under androgen-deprived condition. Furthermore, knockdown of HMGA1 suppressed the cell growth of DU145 and PC-3. CONCLUSIONS These data suggest that elevated expression of HMGA1 is associated with the transition of PCa cells from androgen-sensitive to androgen-independent growth and plays a role in the cell growth of androgen-independent PCa cells. Prostate 72:11241132, 2012. (c) 2011 Wiley Periodicals, Inc.
  • Hideo Saito, Tadashi Matsuda, Kazunari Tanabe, Akihiro Kawauchi, Toshiro Terachi, Ken Nakagawa, Masatsugu Iwamura, Masanobu Shigeta, Katsunori Tatsugami, Akihiro Ito, Jiro Machida, Mutsushi Kawakita, Hidefumi Kinoshita, Nobuo Shinohara, Naomasa Ioritani, Toshimori Seki, Yoichi Arai
    JOURNAL OF ENDOUROLOGY 26 6 652 - 659 2012年06月 [有り][無し]
     研究論文(学術雑誌) 
    Background and Purpose: Despite clear trends toward minimally invasive surgery, information about laparoscopic partial nephrectomy (LPN) in Japan is sparse. We conducted a retrospective survey to clarify time trends for LPN and analyze surgical and oncologic outcomes. Patients and Methods: A nationwide survey was performed. Between 1998 and 2008, 1375 patients underwent LPN at 54 institutions. Complications, patterns of tumor recurrence, and recurrence-free survival were analyzed. Results: Renal pedicle clamping was used in 1031 (75%) cases, and renal cooling was performed in 64%. Median warm/cold ischemic time was 37/53 minutes. Median tumor size was 2.26cm (interquartile range 1.6 to 2.7). Multivariate analysis identified total operative time, operative blood loss, and surgical margin status as independently associated with high grade (grade 3-5) urologic and nonurologic complications. Despite increases in central tumor, a trend was seen toward shorter warm/cold ischemic time in recent cases, and the overall complication rate did not change throughout the study period. With a median follow-up of 26 months for 1193 malignancies, recurrence occurred in 22 (1.7%) patients, including local recurrence in 7 (0.5%), lung in 8 (0.7%), lymph nodes in 2 (0.1%), and bone in 4 (0.3%). Of the 26 cases with positive surgical margins, local tumor recurrence occurred in only one. Conclusions: This is the first nationwide survey of LPN in Japan to be reported. LPN could be performed with acceptable positive margins and complication rates. Most tumor recurrences occur as metastases, and surgical margin status appears to have little impact on oncologic outcomes.
  • Natsuki Takaha, Yoshihiro Sowa, Ichiro Takeuchi, Fumiya Hongo, Akihiro Kawauchi, Tsuneharu Miki
    JOURNAL OF UROLOGY 187 6 2215 - 2222 2012年06月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: Although molecular targeted therapy has improved the clinical outcome of metastatic renal cell carcinoma, a complete response is rare and there are various side effects. Identifying novel target molecules is necessary to improve the clinical outcome of metastatic renal cell carcinoma. HMGA1 is over expressed in many types of cancer and it is associated with metastatic potential. It is expressed at low levels or not expressed in normal tissue. We examined HMGA1 expression and function in human renal cell carcinoma. Materials and Methods: HMGA1 expression in surgical specimen from patients with renal cell carcinoma was examined by immunoblot. HMGA1 expression in 6 human renal cell carcinoma cell lines was examined by immunoblot and immunofluorescence. The molecular effects of siRNA mediated knockdown of HMGA1 were examined in ACHN and Caki-1 cells. Results: Immunoblot using surgical specimen showed that HMGA1 was not expressed in normal kidney tissue but it was expressed in tumor tissue in 1 of 30 nonmetastatic (3%) and 6 of 18 metastatic (33%) cases (p = 0.008). Immunoblot and immunofluorescence revealed significant nuclear expression of HMGA1 in ACHN and Caki-1 cells derived from metastatic sites. HMGA1 knockdown remarkably suppressed colony formation and induced significant apoptosis in ACHN and Caki-1 cells. HMGA1 knockdown significantly inhibited invasion and migration in vitro, and induced anoikis associated with P-Akt down-regulation in ACHN cells. Conclusions: HMGA1 is a potential target for novel therapeutic modalities for metastatic renal cell carcinoma.
  • Takaha N, Nakanishi H, Kimura Y, Hongo F, Kamoi K, Kawauchi A, Mizuno M, Yoshida J, Wakabayashi T, Miki T
    International journal of oncology 40 5 1441 - 1446 2012年05月 [有り][無し]
     研究論文(学術雑誌) 
    We previously reported that cationic multilamellar liposome containing the human interferon-beta (hulFN-beta) gene (IAB-1) demonstrated significant cytotoxic effect in the NC65 human renal cell carcinoma (RCC) cell line. In this study, we investigated the molecular mechanisins of IAB-1-induced apoptosis and cytotoxicity in RCC cells. Remarkable in vitro cytotoxic and apoptosis-inducing effects of IAB-I against NC65 cells were observed by a colorimetric method and TUNEL staining, respectively. In contrast, treatment of NC65 cells with exogenously added huIFN-beta protein induced low-level cytotoxicity without apoptosis. Neutralizing antibodies against huIFN-beta significantly suppressed the cytotoxic effect of hulFN-beta protein, but they were unable to block the effect of IAB-1. Cytotoxicity assays using transwell plates revealed that NC65 cells treated with IAB-1 did not secrete cytotoxic soluble factors other than IFN-beta. Substantial enhancement of interferon-stimulated response element (ISRE) activity of NC65 cells by IAB-1 was demonstrated by promoter reporter assays. In addition, immunofluorescence using confocal microscopy revealed the intracellular expression of IFN-beta and its receptor induced by IAB-1. The induction of c-Myc by IAB-1 was suggested by a cDNA macroarray and was confirmed by western blot analysis. These findings indicate that IAB-1 induces significant cytotoxicity and apoptosis in NC65 cells, possibly through enhanced ISRE activity, that is associated with increased intracellular localization of huIFN-P and IFN-receptor. Our data support the potential clinical application of IAB-1 gene therapy for RCC resistant to IFN.
  • Hui Wang, Yoshiyuki Tanaka, Akihiro Kawauchi, Tsuneharu Miki, Yukihiko Kayama, Yoshimasa Koyama
    NEUROSCIENCE RESEARCH 72 1 43 - 49 2012年01月 [有り][無し]
     研究論文(学術雑誌) 
    Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder activity-related neurons in and around Barrington's nucleus. In 95 of 147 trials (64.6%), acupuncture stimulation of the sacral vertebrae for 1 min suppressed bladder contraction for 27-2347 s. Acupuncture-induced suppression of bladder contraction was blocked by intraperitoneal injection of bicuculline (Bic). Acupuncture stimulation strongly affected bladder activity-related neurons, including those which fired only prior to the start of contraction (Type E1), those whose firing was maintained during contraction (Type E2), and those whose firing was strongly suppressed during contraction (Type I). All Type E1 neurons and most (93.8%) Type E2 neurons decreased firing when bladder activity was suppressed by acupuncture stimulation. Four of 14 (28.6%) Type I neurons exhibited an excitatory response while 3 of 14 (21.4%) exhibited an inhibitory response. These findings suggest that acupuncture stimulation of the sacral vertebrae suppresses bladder contraction and changes the firing properties of bladder activity-related neurons in and around Barrington's nucleus, and that these changes are mediated by GABAergic systems. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
  • Yukio Homma, Momokazu Gotoh, Osamu Yokoyama, Naoya Masumori, Akihiro Kawauchi, Tomonori Yamanishi, Osamu Ishizuka, Narihito Seki, Toshiyuki Kamoto, Atsushi Nagai, Seiichiro Ozono
    INTERNATIONAL JOURNAL OF UROLOGY 18 11 741 - 756 2011年11月 [有り][無し]
     研究論文(学術雑誌) 
    The Japanese Urological Association has developed Clinical Guidelines for Benign Prostatic Hyperplasia (BPH) for men with suspected BPH, which have been abridged and translated into English. This article is a shortened version of the English translation. The Guidelines were formulated on the basis of evidence retrieved from the PubMed database between 1995 and 2009, as well as other relevant sources. The target patients of these Guidelines are men with suspected BPH, and the target users are urologists. A mandatory assessment should include a medical history, a physical examination, the completion of symptom and quality of life questionnaires, urinalysis, prostate ultrasonography, measurement of serum prostate specific antigen and postvoid residual urine, and an uroflowmetry. Optional tests include a bladder diary, the measurement of serum creatinine, and upper urinary tract ultrasonography. Care should be taken to not overlook coexisting diseases such as an infection or malignancy that may obscure the diagnosis. Treatment should consist of conservative therapy or the use of medications such as a1-adrenoceptor antagonists, or both. The use of 5a-reductase inhibitors or anticholinergic agents should be considered in patients with an enlarged prostate (>30 mL) or overactive bladder symptoms (overactive bladder symptom score =6), respectively. Surgical intervention is indicated when non-surgical treatments fail to provide sufficient symptomatic relief and bladder outlet obstruction is highly suspected.
  • Yukio Homma, Momokazu Gotoh, Osamu Yokoyama, Naoya Masumori, Akihiro Kawauchi, Tomonori Yamanishi, Osamu Ishizuka, Narihito Seki, Toshiyuki Kamoto, Atsushi Nagai, Seiichiro Ozono
    INTERNATIONAL JOURNAL OF UROLOGY 18 11 E1 - E33 2011年11月 [有り][無し]
     研究論文(学術雑誌) 
    The Japanese Urological Association has developed Clinical Guidelines for Benign Prostatic Hyperplasia (BPH) for men with suspected BPH. This article is an English translation of the abridged version of the Guidelines. The Guidelines were formulated on the basis of evidence retrieved from the PubMed database between 1995 and 2009, as well as other relevant sources. The target patients of these Guidelines are men with suspected BPH, and the target users are urologists. A mandatory assessment should include a medical history, a physical examination, the completion of symptom and quality of life questionnaires, a urinalysis, a prostate ultrasonography, measurement of serum prostate specific antigen and postvoid residual urine, and uroflowmetry. Optional tests include keeping a bladder diary, the measurement of serum creatinine, and upper urinary tract ultrasonography. Care should be taken to not overlook coexisting diseases such as infections or malignancies that may obscure the diagnosis. Treatment should consist of conservative therapy or the use of medications such as a1-adrenoceptor antagonists, or both. The use of 5a-reductase inhibitors or anticholinergic agents should be considered in patients with an enlarged prostate (>30 mL) or overactive bladder symptoms (Overactive Bladder Symptom Score =6), respectively. Surgical intervention is indicated when non-surgical treatments fail to provide sufficient symptomatic relief, and when bladder outlet obstruction is highly suspected.
  • Toru Matsugasumi, Kazumi Kamoi, Shunji Harikai, Tetsunori Inagaki, Yasunori Kimura, Naoki Hirahara, Jintetsu Sou, Shuichi Nakagawa, Akihiro Kawauchi, Tsuneharu Miki
    Acta Urologica Japonica 57 8 439 - 443 2011年08月 [有り][無し]
     研究論文(学術雑誌) 
    Amyloidosis is characterized by extracellular deposition of abnormal insoluble fibrils, which cause structural and functional disorders. Amyloidosis is classified into systemic and localized amyloidosis. Localized amyloidosis in individual organs is uncommon. We report a rare case of localized form of primary amyloidosis of the urinary bladder. A 76-year-old male visited our hospital with a complaint of macroscopic hematuria. Cystoscopy showed submucosal hematoma in the anterior wall and broad-based mass occupying the trigone without normal mucosa covered by calcification. Transurethral biopsy and resection were performed. Histopathological diagnosis was AL type amyloidosis occupying submucosal extracellular space. We gave the patient occlusive dressing with dimethyl sulfoxide. In 12 months, cystoscopy and magnetic resonance imaging revealed improvement of the mass-like lesion in the bladder wall.
  • Akihiro Kawauchi, Yasuyuki Naitoh, Tsuneharu Miki
    CURRENT OPINION IN UROLOGY 21 4 303 - 308 2011年07月 [有り][無し]
     
    Purpose of review Laparoendoscopic single-site surgery (LESS) has been increasingly reported to be a new less invasive approach. In the field of pediatric urology, in which even the application of laparoscopic surgery is still limited, recent studies are reviewed and the operative method and results evaluated. Recent findings Nephrectomy, nephroureterectomy and partial nephrectomy have been reported in renal surgery. Varicocelectomy, orchidectomy and orchidopexy have been performed for intrascrotal diseases. The postoperative complication of hematoma was observed in one bilateral case out of three nephrectomies, and blood transfusion and percutaneous drainage were needed. Postoperatively, two male patients out of 11 nephrectomy cases developed unilateral ipsilateral hydroceles. A surgical repair of the hydrocele was performed in a 3.9-year-old boy. Summary LESS for pediatric patients in urology is feasible but has just begun, and the number of cases experienced is still small. Further clinical evaluation including a large-scale study and comparison with standard laparoscopic surgery will reveal the true efficacy of this novel procedure.
  • Yukihiro Udo, Masahiro Nakao, Hisashi Honjo, Osamu Ukimura, Akihiro Kawauchi, Hiroshi Kitakoji, Tsuneharu Miki
    BJU INTERNATIONAL 107 5 791 - 798 2011年03月 [有り][無し]
     研究論文(学術雑誌) 
    Level of Evidence 4 What's known on the subject? and What does the study add? Main causes of nocturia are 24-hour polyuria, nocturnal polyuria, decreased bladder capacity and sleep disorder. This study revealed that nocturia is closely related to four factors, namely, 24-hour urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration and evaluation of all these factors through analysis of bladder diaries is clinically important to decide which is the main contributing factor in patients with nocturia and to determine suitable treatment modality on an individual basis. OBJECTIVE center dot To determine the relationship between the number of nocturia and 24-h urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration as well as to assess the significance of these factors with respect to eliminating nocturnal voidings in individual patients with nocturia. PATIENTS AND METHODS center dot Among 532 participants who completed a 3-day bladder diary between April 2005 and December 2006, the diaries of 450 participants without 24-h polyuria were analyzed. center dot Clinical variables such as the number of daytime and night-time voids, 24-h urine volume, nocturnal polyuria index, daytime and night-time maximum voided volumes (MVV), night/day MVV ratio, sleep duration and proportion of night/day urine production rates were obtained from each diary. center dot Participants were classified into eight groups according to values of three factors: nocturnal MVV, proportion of night/day urine production rates and length of sleep duration. center dot Each group was divided into three subgroups: non-nocturics (number of nocturnal voidings is zero), mild nocturics (number of nocturnal voidings is one) and severe nocturics (number of nocturnal voidings is two or more). center dot The data from non-nocturics with three normal factors were regarded as the normal control and compared with the variables of the other subgroups using Dunnett's method. RESULTS center dot Variables that form the basis of classifying participants into eight groups and corresponding to abnormal factors of each group were statistically significant in all the subgroups of each group. center dot Furthermore, a significantly increased 24-h urine volume was found in severe nocturics of the group with three normal factors. center dot A significantly decreased 24-h urine volume was found in non-nocturics of groups with nocturnal polyuria, decreased bladder capacity and both long sleep duration and nocturnal polyuria. center dot A significantly increased nocturnal MVV and night/day MVV ratio were shown in non-nocturics and mild nocturics of the groups with nocturnal polyuria and both long sleep duration and nocturnal polyuria. CONCLUSIONS center dot Because nocturia is a multifactorial disorder and closely related to four factors (i.e. 24-h urine volume, nocturnal urine volume, nocturnal bladder capacity and length of sleep duration), the evaluation of all these factors appears to be clinically useful for determining the main contributing factor in patients with nocturia as well as the suitable treatment modality on an individual basis. center dot Physicians should take all these factors into consideration in the evaluation and treatment of nocturia.
  • Atsushi Ochiai, Koji Okihara, Kazumi Kamoi, Tsuyoshi Iwata, Akihiro Kawauchi, Tsuneharu Miki, Zephyr Fors
    INTERNATIONAL JOURNAL OF UROLOGY 18 3 200 - 205 2011年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To examine the clinical utility of the prostate cancer gene 3 (PCA3) urine test in predicting prostate cancer in Japanese men undergoing prostate biopsy. Method: The study group included 105 men who underwent extended prostate biopsy based on an elevated serum prostate-specific antigen (PSA). In all cases, the patients' race was Asian. Urine specimens were collected after digital rectal examination, and PCA3 score (PCA3/PSA mRNA) was determined in the urine using the APTIMA PCA3 assay. PCA3 score was investigated for a correlation with serum PSA, prostate volume (PV), PSA density and biopsy outcome. Results: All urine samples collected were successfully analyzed (i.e. the informative specimen rate was 100%). Biopsy showed prostate cancer in 38 men (36%). The PCA3 score was not associated with serum PSA nor PV. The median PCA3 score in prostate cancer was significantly higher than that in negative biopsy (59.5 vs 14.2 P < 0.0001). The probability of prostate cancer was 69% at a PCA3 score of more than 50 and 5% at a PCA3 score of less than 20. On multivariable logistic regression, PSA density (P < 0.05) and PCA3 score (P < 0.0001) were the independent predictors for prostate cancer. There was no significant difference in AUC between PCA3 score and PSA density. The combination of PCA3 score and PSA density increased the AUC from 0.72 for PSA alone to 0.88. Conclusion: The specificity of the PCA3 urine assay for prostate cancer was excellent in Japanese men undergoing biopsy. PCA3 score could improve the prediction for prostate cancer and help to better select men who might benefit from prostate biopsy.
  • Kimihiro Yano, Mano Horinaka, Tatsushi Yoshida, Takashi Yasuda, Hiroya Taniguchi, Ahmed E. Goda, Miki Wakada, Sae Yoshikawa, Terukazu Nakamura, Akihiro Kawauchi, Tsuneharu Miki, Toshiyuki Sakai
    INTERNATIONAL JOURNAL OF ONCOLOGY 38 2 365 - 374 2011年02月 [有り][無し]
     研究論文(学術雑誌) 
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising anti-cancer agents, but some tumor types develop resistance to TRAIL. Here, we report that chetomin, an inhibitor of hypoxia-inducible factors, is a potent enhancer of TRAIL-induced apoptosis. TRAIL or chetomin alone weakly induced apoptosis, but the combination of chetomin and TRAIL synergistically induced apoptosis in prostate cancer PC-3 cells. The combination of chetomin and TRAIL induces the activation of caspase-3, -8, -9 and -10. Among the apoptotic factors related to the TRAIL pathway, chetomin markedly decreased the X-linked inhibitor of apoptosis (XIAP) protein levels in a dose-dependent manner, but other LAP family members, TRAIL receptors and Bcl-2 family members were not altered by chetomin. Using XIAP siRNA instead of chetomin, down-regulation of XIAP sensitized PC-3 cells to TRAIL-induced apoptosis. Conversely, transient transfection of XIAP reduced the apoptotic response to combined treatment with chetomin and TRAIL. Treatment with chetomin induced a rapid decrease in XIAP protein levels but had no effect on XIAP rnRNA levels. Since chetomin-mediated XIAP down-regulation was completely prevented by proteasome inhibitors, it was suggested that chetomin induces the degradation of the XIAP protein in a proteasome-dependent manner. Additionally, chetomin also sensitized renal cancer Caki-1 cells and bladder cancer UM-UC-3 cells to TRAIL-induced apoptosis via down-regulation of XIAP. Co-treatment of chetomin and TRAIL did not enhance apoptosis in normal peripheral blood mononuclear cells (PBMC). Taken together, these findings suggest that TRAIL and chetomin synergistically induce apoptosis in human urogenital cancer cells through a mechanism that involves XIAP down-regulation by chetomin.
  • Kaori Nishida, Sachiko Yuen, Kazumi Kamoi, Kei Yamada, Kentaro Akazawa, Hirotoshi Ito, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki, Tsunehiko Nishimura
    ACTA RADIOLOGICA 52 1 120 - 126 2011年02月 [有り][無し]
     研究論文(学術雑誌) 
    Background: For men with clinically localized prostate cancer and candidates to receive radical prostatectomy (RP) a main concern is a cancer recurrence after treatment. Although previous studies have demonstrated the diagnostic utility of diffusion-weighted imaging (DWI) for prostate cancer, the prognostic value of pretreatment DWI has not been investigated yet. Purpose: To investigate the incremental value of MRI-based T staging using DWI and T2-weighted imaging (T2WI) as compared with the clinical parameters in prediction of biochemical recurrence (BCR) after RP for clinically localized prostate cancer. Material and Methods: Sixty MR examinations, obtained before RP between April 2002 and March 2009, were retrospectively reviewed using T2WI alone, DWI alone, or T2WI + DWI for T staging according to the 2002 American Joint Committee on Cancer guidelines. The relationship between MRI stage and BCR was evaluated using Kaplan-Meier survival estimates. Multivariate analysis and receiver operating characteristics (ROC) curve analysis were used to investigate the incremental value over the standard clinical variables in prediction of BCR. Results: As of August 2009, 12 (20%) patients had BCR. Based on T2WI DWI, both T3a (compared to OC disease) and T2 (compared to T1c) showed significantly higher BCR rates (p = 0.047 and 0.025, respectively). Multivariate analysis and area under ROC curve analysis confirmed the additional value of MRI staging to the conventional clinical variables in prediction of BCR. Conclusion: The combination of T2WI and DWI on performing pretreatment MRI helped predict BCR after RP in clinically localized prostate cancer.
  • Natsuki Takaha, Koji Okihara, Kazumi Kamoi, Yasunori Kimura, Takeshi Yamada, Akihiro Kawauchi, Kana Kobayashi, Hideya Yamazaki, Tsunehiko Nishimura, Tsuneharu Miki
    UROLOGIA INTERNATIONALIS 87 1 28 - 34 2011年 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To evaluate the efficacy and toxicity of external beam radiation therapy (EBRT) combined with androgen deprivation therapy (ADT) for Japanese high-risk prostate cancer (PCa) patients in a single institution. Methods: Seventy-five high-risk PCa patients were treated by three-dimensional conformal radiotherapy of 70 Gy combined with neo-adjuvant, concurrent and adjuvant ADT. Results: Median age was 72 (59-82) years. Median initial serum prostate-specific antigen (PSA) was 19.0 (4.7-200) ng/ml. Median duration of the entire ADT was 27 (8-63) months. Median follow-up after initiating ADT and after completing EBRT was 66 (41-105) and 59 (36-94) months, respectively. Five-year overall, clinical progression-free, and biochemical progression-free survival rates were 98.3, 97.2, and 87.4%; 2 (2.7%) cancer deaths, 3 (4.0%) clinical progressions, and 11 (14.7%) biochemical progressions. Multivariate analysis suggested a total duration of ADT shorter than 24 months as an independent risk factor of biochemical progression (p = 0.01). Grade 3 toxicities related to EBRT were observed: 1 patient with proctitis and rectal bleeding and 1 patient with rectal bleeding. Conclusions: It is suggested that 70 Gy EBRT combined with ADT confers disease-free survival benefit with tolerable adverse events for Japanese high-risk PCa patients. ADT of 24 months or longer might be recommended to minimize biochemical progression. Copyright (C) 2011 S. Karger AG, Basel
  • Natsuki Takaha, Koji Okihara, Kazumi Kamoi, Fumiya Hongo, Tsuyoshi Iwata, Kimihiro Yano, Takashi Ueda, Ichiro Takeuchi, Takeshi Yamada, Akihiro Kawauchi, Tsuneharu Miki
    UROLOGIA INTERNATIONALIS 87 3 263 - 269 2011年 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To evaluate the efficacy and safety of docetaxel-based chemotherapy for elderly metastatic castration-resistant prostate cancer (CRPC) patients aged 75 or higher. Methods: Twenty CRPC patients aged 75 or higher (older group) and 31 CRPC patients younger than 75 years (younger group) were treated by a regimen of docetaxel (70 mg/m(2)) once every 3 weeks. Adjustment for docetaxel dosage and period per cycle was subject to investigator's judgment. Results: The median relative dose intensity of both groups was 0.84, while the median dose intensity and the number of treatment cycles of the younger and older groups were 14.6 versus 12.3 mg/m(2)/week (p = 0.021), and 9 versus 8 cycles (p = 0.15), respectively. In the older group, PSA response rate was 50%, median time to biochemical progression was 7.5 months, and median survival time was 15.5 months, without any significant difference compared to those of the younger group. No significant difference in the incidence of grade 3-4 adverse events was noted between both groups. All these parameters for efficacy are comparable to those reported for tri-weekly docetaxel regimen. Conclusions: Triweekly treatment by docetaxel (70 mg/m(2)) with proper adjustment might contribute to maintaining efficacy and safety of the treatment for elderly CRPC patients. Copyright (C) 2011 S. Karger AG, Basel
  • Jintetsu Soh, Akihiro Kawauchi, Noriyuki Kanemitsu, Yoshio Naya, Atsushi Ochiai, Yasuyuki Naitoh, Terufumi Fujiwara, Kazumi Kamoi, Tsuneharu Miki
    JOURNAL OF SEXUAL MEDICINE 7 11 3743 - 3749 2010年11月 [有り][無し]
     研究論文(学術雑誌) 
    Introduction. Various conservative treatments for Peyronie's disease (PD) have been attempted over the years. Intralesional verapamil injection has been tested in prospective randomized studies, but the effect of this treatment seems insufficient. Nicardipine is a calcium antagonist alternative to verapamil and is reportedly more effective in vitro. Aim. The objective of our study was to evaluate the usefulness of intralesional nicardipine injection as a conservative treatment for PD in the transition period of acute and chronic phase. Methods. Eighty-six patients (age: 38-72 years, mean: 52) were enrolled in this study. A total of 74 patients were assigned randomly to nicardipine group (10 mg diluted in 10 mL of distilled water daily, N = 37) and control group (10 mL of saline water, N = 37). A total of six injections were administrated biweekly. Mean Outcome Measure. The subjects were assessed by International Index of Erectile Function (IIEF)-5 and international pain scale. The plaque size was measured by ultrasonography after 20 mu g intracavernosal injection of alprostadil (prostaglandin E1). The penile curvature was also measured by taking a photograph at maximum rigidity. Results. A reduction of pain score was seen throughout the course of treatment in both groups with a significant difference between the nicardipine and control groups (multiple analysis of variance test, P = 0.019). A significant improvement of IIEF-5 score occurred only in the nicardipine group at 48 weeks after the initiation of treatment (P < 0.01). The plaque size was significantly reduced at 48 weeks only in the nicardipine group (12 points, P = 0.0004 by paired t-test). The penile curvature was significantly improved in both groups (P < 0.01) without significant difference between them (P = 0.14). There were no severe side effects, such as hypotension or other cardiovascular events. Conclusion. Our findings indicate that intralesional nicardipine injection is clinically effective as a conservative treatment for PD in the transition period of acute and chronic phase. Soh J, Kawauchi A, Kanemitsu N, Naya Y, Ochiai A, Naitoh Y, Fujiwara T, Kamoi K, and Miki T. Nicardipine vs. saline injection as treatment for Peyronie's disease: A prospective, randomized, single-blind trial. J Sex Med 2010;7:3743-3749.
  • Hiroshi Iwasaki, Eiichi Jodo, Akihiro Kawauchi, Tsuneharu Miki, Yukihiko Kayama, Yoshimasa Koyama
    BRAIN RESEARCH 1357 70 - 78 2010年10月 [有り][無し]
     研究論文(学術雑誌) 
    To elucidate the role of the preoptic area (POA) in the regulation of penile erection, we examined the effects of electrical stimulation in and around the POA on penile erection in rats, which was assessed by changes in pressure in the corpus spongiosum of the penis (CSP) and electromyography (EMG) of the bulbospongiosus (BS) muscle. In unanesthetized and anesthetized rats, four types of responses were induced by stimulation in and around the POA; (1) normal type responses, which were similar to spontaneously occurring erections, characterized by slow increase in CSP pressure and sharp peaks concurrent with BS muscle bursting (2) muscular type responses, which included sharp CSP pressure peaks (muscular component) with almost no vascular component; (3) mixed type responses, which included a sequence of high-frequency CSP peaks followed by low-frequency CSP peaks; and (4) micturition type responses, which had higher-frequency and lower-amplitude CSP peaks than other responses which were identical to those of normal micturition. In unanesthetized condition, erections were evoked by stimulation of the lateral preoptic area (LPOA), medial preoptic area (MPOA), bed nucleus of the stria terminalis (BST), paraventricular nucleus (PVN), reuniens thalamic nucleus (Re) and lateral septum (LS). Lower-intensity stimulation evoked erections from the LPOA, BST, PVN and RE, but not the MPOA. In anesthetized condition, stronger stimuli were required and effective sites were restricted to the LPOA, MPOA and BST. These findings suggest that the lateral and medial subdivisions of the preoptic area play different roles in mediating penile erection. (C) 2010 Elsevier B.V. All rights reserved.
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintetsu Soh, Kazumi Kamoi, Tsunaharu Miki
    UROLOGY 75 6 1509 - 1513 2010年06月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVES To develop a new shape memory alloy probe for percutaneous treatment of renal cell carcinoma (RCC) by electrovaporization, and investigate its efficacy and safety in experimental models. METHODS The shape memory alloy electrode can be manipulated to any shape at room temperature and regains its original shape at >= 65 degrees C. By adding a high-frequency electric current to the probe, the electrodes quickly regain their original shape and vaporize tissues into a spherical defect. The performance of this probe was tested using agar, dog kidney, and rat RCC models. The treatment effect was evaluated by magnetic resonance imaging and histologic examination. RESULTS In the agar model, the electrovaporization inside the spherical electrode was successfully achieved in several seconds, with all power outputs tested. The area of >= 60 degrees C extended about 5 mm beyond the periphery of the vaporized part and corresponded with the histologic findings on the dog kidney that an irreversible heat denaturation occurred to the same extent. The study on the RCC model also confirmed that about 5-mm extent of heat denaturation was seen in the muscular tissue adjacent to the tumor. In the study using the RCC model, some remaining tissues close to the tumor were observed after vaporization. However, dynamic magnetic resonance imaging demonstrated no enhancement in this area and no viable tumor cells were documented by histologic examination. CONCLUSIONS This novel tissue ablation system has potential as a viable option for percutaneous treatment of renal tumors. UROLOGY 75: 1509-1513, 2010. (c) 2010 Elsevier Inc.
  • Koichi Okada, Koji Okihara, Koji Kitamura, Kazuya Mikami, Osamu Ukimura, Akihiro Kawauchi, Kazumi Kamoi, Masahiro Nakao, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 17 6 541 - 547 2010年06月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To assess possible predictors in determining criteria for repeat biopsy in a prostate cancer screening population. Methods: A total of 50 207 men over 55 years-of-age have participated in a prostate cancer screening program in Otokuni, Kyoto, Japan for 12 years. Transperineal systematic biopsy was carried out in case of positive digital rectal examination (DRE) or positive transrectal ultrasonography (TRUS) or a prostate-specific antigen (PSA) value greater than 10.0 ng/mL. For those with a PSA level from 4.1 to 10.0 ng/mL, and negative DRE and TRUS findings, biopsy was indicated only when PSA density (PSAD) was greater than 0.15. The same indication was applied for the repeat biopsy. Results: A repeat biopsy after an interval of more than 2 years was carried out in 140 patients and was positive in 50 (36%) patients. The PSA value at the diagnosis of cancer declined from the initial value in six (12%) patients. On multivariate logistic regression analysis, PSA velocity (PSAV) as well as PSAD and DRE findings at latest screening were independent predictors for positive repeat-biopsy outcome. The odds ratio (95% confidence intervals) of PSAV > 0.48, latest PSAD > 0.33 and positive latest DRE were 4.17 (1.05-18.5), 4.15 (1.31-14.0), and 3.62 (1.06-13.2), respectively. A combination of three variables defined as positive if any of these were positive, reduced 31% of unnecessary biopsies while missing 8% of low volume, low grade cancers. Conclusions: A combination of latest PSAD, PSAV and positive DRE at latest screening might help to reduce unnecessary repeat biopsies in high-risk patients with an initial negative biopsy.
  • Akihiro Kawauchi, Kazumi Kamoi, Jintetsu Soh, Yasuyuki Naitoh, Koji Okihara, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 17 3 289 - 292 2010年03月 [有り][無し]
     研究論文(学術雑誌) 
    The objective of this paper is to report our initial experience in laparoendoscopic single-site surgery (LESS). One patient underwent LESS varicocelectomy and another patient underwent LESS pyeloplasty. The Triport was inserted into the abdomen through the umbilical incision. In the varicocelectomy, testicular vessels were coagulated by a vessel-sealing system, and transected. In the pyeloplasty, a 2-mm needlescopic port was added to facilitate the procedure, and a dismembered procedure was performed. Total operative duration was 60 min for the varicocelectomy and 240 min for the pyeloplasty. Blood loss was minimal and no perioperative complications occurred. At the 3-month follow up, no postoperative complications were observed and there was no complaint of pain. LESS varicocelectomy and pyeloplasty were successfully performed with excellent cosmetic results and no complications.
  • Kenji Hiraoka, Hiroaki Miyazaki, Naomi Niisato, Yoshinobu Iwasaki, Akihiro Kawauchi, Tsuneharu Miki, Yoshinori Marunaka
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 25 4-5 379 - 388 2010年 [有り][無し]
     研究論文(学術雑誌) 
    In the present study, we investigated if the intracellular Cl(-) affects cell growth and cell cycle progression of androgen-independent prostate cancer PC3 cells. PC3 cells cultured in a medium containing 113 mM C(l)- for 96 h grew up 9-fold in cell number, while PC3 cells cultured in an 8 mM-Cl(-)-containing culture medium showed complete arrest of cell growth even after culture for 96 h. Exposure of cells to the 8 mM-Cl(-) culture medium diminished phosphorylation levels of Rb and cdc2, which are respectively key accelerators of transition from G(1) to S phase and G(2) to M phase in cell cycle progression. Culturing cells in the 8 mM-Cl(-)-containing culture medium upregulated the protein expression level of p21 (a CDK inhibitor) inhibiting transition of G(1) to S phase, and diminished the incorporation of 5-ethynyl-2'-deoxyuridine (EdU; a thymidine analogue) into DNA. These results suggest that cells cultured in the low Cl(-) medium prolonged the duration of all phases of the cell cycle (G(1), S, and G(2)/M), thereby abolishing overall cell cycle progression. Effects of culturing cells in the low Cl(-) culture medium on cell cycle progression would be mediated via a change in the intracellular Cl(-) concentration ([Cl(-)](i)), since [Cl(-)](i) was decreased under a low Cl(-) culture medium. To clarify this possibility, we studied effects of furosemide and bumetanide, Na(+)/K(+)/2Cl(-) cotransporter (NKCC) inhibitors, on proliferation of PC3 cells. Furosemide and bumetanide decreased [Cl(-)](i) and cell growth of PC3 cells. These results suggest that a change in [Cl(-)](i) would play a critical role in this growth mechanism. Copyright (C) 2010 S. Karger AG, Basel
  • Nodoka Sato, Yoichi Mizutani, Yong Nan Li, Jun Fujiwara, Hirokazu Ishida, Daisuke Toiyama, Koichi Abe, Issei Hayashi, Hiroyuki Nakanishi, Akihiro Kawauchi, Tsuneharu Miki
    UROLOGIA INTERNATIONALIS 84 3 362 - 368 2010年 [有り][無し]
     研究論文(学術雑誌) 
    Background: Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in synergistic apoptosis. We examined whether the selective COX-2 inhibitor JTE-522 synergizes with anticancer agents in cytotoxicity and apoptosis against RCC cells. Methods: The cytotoxicity of the selective COX-2 inhibitor JTE-522 and other anticancer agents against the RCC cell lines and the normal renal cell line was determined by the microculture tetrazolium dye assay. Results: JTE-522 was cytotoxic against the Caki-1 RCC cell line. JTE-522 and anti-Fas monoclonal antibody (CH-11) exhibited a synergistic cytotoxic effect against Caki-1 cells. In contrast, JTE-522 in combination with 5-fluorouracil, adriamycin, cis-diammine-dichloroplatinum, or interferon-alpha, all commonly used clinically, resulted in an additive cytotoxic effect. Synergy achieved in cytotoxicity with JTE-522 and CH-11 was shown to be due to apoptosis. Conclusions: The present study demonstrated that the selective COX-2 inhibitor JTE-522 had a cytotoxic effect on RCC and that synergistic cytotoxicity against RCC was obtained with JTE-522 in combination with anti-Fas monoclonal antibody. These results suggest that selective COX-2 inhibitors in combination with immunotherapy may be useful in treating patients with RCC. Copyright (C) 2010 S. Karger AG, Basel
  • Hisashi Honjo, Akihiro Kawauchi, Masahiro Nakao, Osamu Ukimura, Hiroshi Kitakoji, Tsuneharu Miki
    NEUROUROLOGY AND URODYNAMICS 29 7 1286 - 1289 2010年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: Bladder diaries including bladder perception grade were analyzed to assess convenience void (CV) in community-dwelling women 40 years of age or older. Methods: A total of 310 women completed a 3-day bladder diary with a grade for bladder perception. The grade was defined on scores 0-5 as follows: 0 = No bladder sensation, 1 = Sensation of bladder filling without desire to void, 2 = Desire to void, 3 = Strong desire to void, 4 = Urgency without urge urinary incontinence (UUI), and 5 = Urge incontinence episode. CV was defined as void without desire to void: when the grade was 0, CV in a narrow sense, and when 0 or 1, CV in a broad sense. Results: The incidence of CV in the broad sense significantly decreased with age. Of the 310 women, 48 (15.5%) had overactive bladder (OAB) symptoms on the medical interview, including 37 (11.9%) without UUI (OAB-Dry) and 11 (3.5%) with UUI (OAB-Wet). Of the remaining 262 women, 111 (35.8%), who had urgency but a urinary frequency of 7 or less, and another 141 (48.7%) were classified into the Normal with Urgency and Normal without Urgency groups, respectively. The incidence of CV in a broad sense in the Normal without Urgency group was significantly greater than that in the Normal with Urgency and OAB-Wet groups. The mean voided volumes of CV in the broad sense in the OAB-Wet group were significantly smaller than those in the other three groups. Conclusions: The evaluation of CV may be a new tool in assessing storage condition and voiding dysfunction. Neurourol. Urodynam. 29:1286-1289, 2010. (C) 2010 Wiley-Liss, Inc.
  • Akihiro Kawauchi, Yasuyuki Naitoh, Jintetsu Soh, Naoki Hirahara, Koji Okihara, Tsuneharu Miki
    JOURNAL OF ENDOUROLOGY 23 11 1875 - 1878 2009年11月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: Transvesical laparoscopic cross-trigonal ureteral reimplantation (TLCUR) has been reported as an alternative procedure for vesicoureteral reflux mainly in pediatric cases. We review our initial experience with TLCUR and evaluate its feasibility in adult patients. Patients and Methods: We performed TLCUR in 30 patients (22 females and 24 bilateral cases) with a median age of 14.5 years. Results: The median operating time was 145 minutes in the unilateral cases and 230 minutes in the bilateral cases. Blood loss was minimal in all cases. No intraoperative complications were observed. The urethral catheter was removed at day 2 to 3. One persistence of reflux and one uretero-vesico anastomosis stricture were observed. The total success rate of 49 ureters in 27 patients, in whom postoperative cystography was performed, was 96% (47/49). Comparing the first 15 and last 15 cases, patient age was similar, the operation time was significantly shorter in the last 15 cases, and both operative failures were found in the first 15 cases. Comparing the 15 pediatric and 15 adult cases, the operation time did not differ between the two groups and one operative failure was observed in each group. Conclusion: This procedure was an effective and safe alternative minimally invasive procedure for both adult and pediatric patients with reflux.
  • Kenji Hiraoka, Akihiro Kawauchi, Terukazu Nakamura, Jintetsu Soh, Kazuya Mikami, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 16 11 869 - 873 2009年11月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To report our results of percutaneous radiofrequency ablation (RFA) for renal tumors and to assess predictors of therapeutic efficacy. Methods: Forty patients (median age 73 years) with renal tumors were treated with RFA under local or epidural anesthesia. All of them had high surgical risk or refused radical surgery. Tumors were punctured percutaneously using the Radionics Cool-tip RF System under computed tomography or ultrasonographic guidance. Median tumor diameter was 24 mm. After RFA, contrast-enhanced computed tomography or magnetic resonance imaging was performed within 1 month. Complete response (CR) was defined as no enhancement inside the tumor. Factors related to the outcome and to renal function were assessed. Results: Median follow up was 16 months. CR was observed in 34 cases (85.0%). A significant difference in CR rate was observed between tumors < 30 mm and those > 30 mm. Outcomes tended to be better for tumors in the mid to lower kidney, and those away from the renal hilum. Recurrence was observed in one case (2.9%), but a CR was obtained again by additional RFA. Out of a total of 77 RFA procedures, complications occurred in only three cases (3.9%), and conservative treatment was possible in all cases. Serum creatinine levels 3 months after RFA did not differ from those before RFA. Conclusions: Percutaneous RFA is a safe and effective treatment for small renal tumors in patients with high surgical risk or who refuse radical surgery.
  • Kei Suzuki, Akihiro Kawauchi, Tatsuo Nakamura, Shin-ichi Itoi, Tadao Ito, Jintetu So, Osamu Ukimura, Akeo Hagiwara, Hisakazu Yamagishi, Tsuneharu Miki
    UROLOGY 74 4 958 - 963 2009年10月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVES To determine the rate of achieving electrophysiologically proved functional recovery by autonomic nerve regeneration, with the aid of an artificial nerve conduit. METHODS A polyglycolic acid (PGA) collagen nerve conduit filled with collagen sponge was interposed in a 10-mm-long gap of the right hypogastric nerve (HON) in 16 dogs. Histologic evaluation of nerve regeneration and electrophysiological analysis at 2 weeks and 2, 3, 4, 5, 6, 7, and 8 months (n = 2, each) after surgery was performed, measuring the responses for the spermatic ducts (SD), bladder neck (BN), and prostate contraction, by stimulating the right lumbar splanchnic nerves (LSNs) from L2 to L4, after transection of the left HGN to eliminate substitutive pathways. RESULTS Two months after implantation, the regenerated neurofilaments were successfully extended through the graft from the proximal-to-distal direction. In 2 control dogs, electrostimulation of the right LSNs induced elevation of the intraluminal pressure of the SD, elevation of the BN pressure, and prostate contraction. No responses were observed in all dogs up to 6 months of follow-up after implantation. In I dog with a 7-month follow-up, electrostimulation elicited elevation of BN pressure alone. In both dogs with an 8-month follow-up, electrostimulation induced similar responses to control in all SD, BN, and prostate; however, after excision of the area of the interposed right HON, no response was observed. CONCLUSIONS These results proved that regeneration of a 10-mm gap of the HGN, using a novel PGA-collagen nerve conduit could be achieved within 8 months. UROLOGY 74: 958-963, 2009. (C) 2009 Elsevier Inc.
  • Koji Okihara, Kazumi Kamoi, Motohiro Kanazawa, Takeshi Yamada, Osamu Ukimura, Akihiro Kawauchi, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 16 10 820 - 825 2009年10月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To assess the impact of transrectal ultrasound (TRUS) navigation on positive margin rates and membranous urethral length (MUL) after minilaparotomy radical retropubic prostatectomy (MRP). Methods: Rates of positive distal margins prior to and after the application for TRUS navigation during MRP were assessed. Of the 189 men undergoing MRP at our institution, 70 were evaluated for the clinical usefulness of preoperative and postoperative MUL. Patients filled out self-administrated questionnaires concerning continence status at 1, 3, 6, 9, and 12 months after the MRP. Surgery-related factors including MUL were analyzed for the prediction of urinary continence after MRP. Results: With the application of TRUS, the rate of positive distal margins decreased by 14%. Postoperative MUL was an independent variable predictive of urinary continence 1 month after surgery. Patients with a MUL longer than 12 mm showed a significantly more favorable recovery from urinary incontinence after surgery. Conclusion: Application of TRUS results in a lower rate of positive margins, and a longer postoperative MUL is associated with an earlier return to urinary continence after MRP.
  • Takumi Shiraishi, Terukazu Nakamura, Kazuya Mikami, Natsuki Takaha, Akihiro Kawauchi, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 14 5 436 - 441 2009年10月 [有り][無し]
     研究論文(学術雑誌) 
    We investigated the efficacy and toxicity of a regimen consisting of paclitaxel and gemcitabine plus nedaplatin, a derivative of cisplatin (TGN) in patients with heavily pretreated cisplatin-refractory germ cell tumors (GCTs). Fifteen patients with advanced GCTs were treated with the TGN regimen. The combination chemotherapy consisted of paclitaxel (210 mg/m(2)) on day 1 and gemcitabine (1000 mg/m(2)) on days 1 and 8 in combination with nedaplatin (100 mg/m(2)) on day 2 every 3 weeks. Patients enrolled in this study had been heavily pretreated with a median of 12 platinum-containing cycles (range, 7 to 26 cycles). Most of the regimens had included paclitaxel and ifosfamide plus cisplatin or nedaplatin (TIP/TIN) chemotherapy. The median follow-up period of the present study was 15 months. Patients received 2-11 cycles of the TGN combination chemotherapy. Six patients received the treatment combined with other therapeutic modalities; 2 patients received radiation therapy for retroperitoneal lymph node metastasis, 1 patient had cyber-knife radiosurgery for brain metastasis and 3 patients had radiofrequency ablation for liver and lung metastasis. Seven (46.7%) of the 15 patients achieved an objective response; 6 had marker-negative partial responses (PRs) and 1 had a marker-positive PR. Two (13%) of the 7 patients with PRs achieved a disease-free status after chemotherapy combined with RT and followed by surgical resection. However, 10 patients died of the disease and 3 patients are still alive with the disease. The TGN regimen alone had limited efficacy in this patient population, with severe but manageable toxicities. However, TGN chemotherapy may offer a chance of cure for some heavily pretreated cisplatin-refractory (TIP/TIN-refractory) patients as part of multidisciplinary therapy.
  • Osamu Kamihira, Ryohei Hattori, Akito Yamaguchi, Gen Kawa, Osamu Ogawa, Tomonori Habuchi, Akihiro Kawauchi, Jiro Uozumi, Shigeaki Yokoi, Masao Tsujihata, Yoshihiro Hasui, Keiko Miyakoda, Harue Tada, Yoshinari Ono, Seiji Naito
    EUROPEAN UROLOGY 55 6 1397 - 1409 2009年06月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Laparoscopic nephroureterectomy (LNUx) is prevalent in Japan and throughout the world, but long-term outcome data remain limited. Objective: To understand the present state of LNUx in Japan, we conducted a multicenter analysis of clinical outcome and long-term cancer control for patients who underwent the procedure. Design, setting, and participants: Between January 1995 and December 2005, 1003 patients with urothelial cancer in the upper urinary tract were treated with LNUx at 51 institutions in Japan, and patient data were collected retrospectively. Measurements: Patient profiles were gathered and analyzed for survival, intravesical recurrence, and risk factors influencing them. Results and limitations: Median operative time was 320 min. Median bleeding volume was 232 ml. Complications occurred in 93 cases (9.3%) intraoperatively and in 107 cases (10.7%) postoperatively. Overall survival rate was 70% at 5 yr. Grade 3, pT3 or pT4, multifocal tumor, lymph-node metastasis, and previous or coexistent bladder tumor were independent risk factors for overall survival. Intravesical recurrence rate was 43% at 5 yr. Intravesical recurrence occurred more frequently in males, in patients with multifocal tumors, in patients with previous or coexistent bladder tumors, and in patients who underwent the hand-assisted approach. Conclusions: Our report represents the largest multicenter analysis of LNUx reported to date. Male sex and the use of the hand-assisted approach were shown for the first time to be risk factors for recurrence-free survival and intravesical recurrence. To further analyze the effectiveness of LNUx, a long-term outcome comparison with risk stratification must be made between LNUx and open nephroureterectomy. (C) 2009 European Association of Urology. Published by Elsevier B.V. All rights reserved.
  • Tsuneharu Miki, Yoichi Mizutani, Terukazu Nakamura, Akihiro Kawauchi, Akira Nagahara, Norio Nonomura, Akihiko Okuyama
    INTERNATIONAL JOURNAL OF UROLOGY 16 4 379 - 382 2009年04月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To report our experience with post-chemotherapy nerve-sparing retroperitoneal lymph node dissection (RPLND) for advanced germ cell tumor (GCT). Methods: Between 1994 and 2008, 92 patients with advanced GCT underwent RPLND after multiple treatments with systemic chemotherapy at our institution. A nerve-sparing RPLND was carried out in 78 patients (84.8%; median age 32 years). Of them, 19 had a seminoma and 59 had a non-seminoma. Results: Lumbar splanchnic nerves controlling ejaculatory function were macroscopically preserved during RPLND. Bilateral and unilateral lumbar splanchnic nerves were preserved in 40 patients and 38 patients, respectively. Sixty-five patients could be evaluated for ejaculation. Fifty-four patients (83.1%) achieved antegrade ejaculation with a median postoperative interval of 3 months (range: 1-10 months). Twenty-eight patients (28/30: 93.3%) and 26 patients (26/35: 74.3%) undergoing bilateral and unilateral nerve-sparing RPLND had antegrade ejaculation, respectively (P = 0.041). Only two patients (2.6%) had mediastinal and retroperitoneal recurrences during a median follow-up of 42 months (range: 1-138 months), respectively. However, these patients were cured by chemotherapy and surgery. Conclusions: Post-chemotherapy nerve-sparing RPLND preserves ejaculatory function in the majority of patients with advanced GCT without increasing the risk of local recurrence.
  • Yoichi Mizutani, Akihiro Kawauchi, Benjamin Bonavida, Tsuneharu Miki
    Renal Cell Carcinoma: Molecular Targets and Clinical Applications 335 - 346 2009年 [有り][無し]
     論文集(書籍)内論文 
    Renal cell carcinoma (RCC) accounts for about 2% of all cancer cases worldwide. Metastatic disease is often present at time of diagnosis of RCC, and its poor prognosis is determined by its poor response to chemotherapy and radiotherapy. Immunotherapy including interleukin-2 and interferon-α is relatively effective against metastatic RCC however, the response rate is 15-20%. Chemotherapy, immunotherapy and radiotherapy have been shown to mediate their cytotoxic and antitumor effects by inducing cell death by apoptosis. The poor response of RCC to conventional therapies may be due in large part to the development of resistance to cell death by apoptosis through the modification of apoptosis regulatory gene products. Such genes and their products may also have important utility as diagnostic/ prognostic markers and therapeutic targets in this disease. However, few genes of this nature have been found to date in RCC. This chapter introduces second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pl (Smac/DIABLO), a gene product of significant prognostic and therapeutic significance in RCC. Smac/DIABLO was recently identified as a protein that is released from mitochondria in response to apoptotic stimuli and promotes apoptosis by antagonizing inhibitor of apoptosis proteins. Smac/DIABLO is a new biomarker for RCC. The level of expression of Smac/DIABLO and its biological activity determine in large part the pathogenesis and fate of RCC and its response to antitumor cytotoxic agents, including chemotherapy, immunotherapy, etc. In addition, Smac/DIABLO offers a promising target for therapy by agents that regulate its expression and stabilization. Such agents, when used in combination with subtoxic doses of chemotherapy and/or immuno-therapy, may be very effective in killing the resistant RCC cells and improve survival. Thus, the level of expression of Smac/DIABLO in RCC has implications in the pathogenesis, diagnosis, and the development of new treatment modalities. © 2009 Humana Press.
  • Hisashi Honjo, Akihiro Kawauchi, Osamu Ukimura, Masahiro Nakao, Hiroshi Kitakoji, Tsuneharu Miki
    NEUROUROLOGY AND URODYNAMICS 28 8 982 - 985 2009年 [有り][無し]
     研究論文(学術雑誌) 
    Aim: Bladder diaries including bladder perception grades were analyzed to assess overactive bladder (OAB) symptoms in community-dwelling women 40 years of age or older. Methods: Three hundred ten women (mean 58 years) completed a 3-day bladder diary. The perception grades were defined as follows: 0 = no bladder sensation, 1 = sensation of bladder filling without desire to void, 2 = desire to void, 3 = strong desire to void, 4 = urgency without urge urinary incontinence (UUI), and 5 = urgency with UUI. Results: Forty-eight women (15.5%) had OAB symptoms on medical interview, including 37 (11.9%) without UUI (OAB-Dry) and 11 (3.5%) with UUI (OAB-Wet). In the analysis of 5,709 voids, the voided volume significantly increased with the grades of perception. The 24 hr voided volume in the OAB-Dry group was significantly larger than that in the Normal group. The average voided volume in the OAB-Wet group was significantly smaller than in the OAB-Dry and the Normal groups. The mean voided volume at grade 3 in the Normal without urgency group was significantly larger than volumes in any other group. In the analysis of grades 4 and 5, voided volumes in the OAB-Wet group were significantly smaller than those in the Normal and/or OAB-Dry groups. Conclusions: A bladder diary that includes a new bladder perception grade was thought to be useful in assessing urinary sensation or incontinence as well as voiding pattern. The causes of symptoms such as urgency or urinary frequency may be different between the Normal, OAB-Dry, and OAB-Wet groups. Neurourol. Urodynam. 28:982-985, 2009. (C) 2009 Wiley-Liss, Inc.
  • Jun Fujiwara, Terukazu Nakamura, Takumi Shiraishi, Kazuya Mikami, Natsuki Takaha, Osamu Ukimura, Akihiro Kawauchi, Tsuneharu Miki, Takuji Yamagami, Tsunehiko Nishimura
    Japanese Journal of Cancer and Chemotherapy 36 12 2117 - 2120 2009年 [有り][無し]
     研究論文(学術雑誌) 
    Radio-frequency ablation (RFA) has been successfully applied for local control of metastatic tumor. The aim of this study was to assess the effectiveness and safety of RFA to post-chemotherapeutic metastatic germ cell tumors (GCTs). As combined modality therapy, RFA was performed to 42 tumors in 19 patients of GCTs at our institution between November 2000 and December 2008. RFA was performed for 10 liver metastatic tumors (in 6 cases), 32 lung metastatic tumors (in 13 cases), and median age was 36 years old (range 20-53) and the median tumor size was 12 mm (range 2-40). We used Cool-tip RF system (straight electrode needle of the internal cooling type, Radionics, Palm Coast, USA) for RFA with ultrasound or CT fluorosent guidance under intravenous or local anesthesia. The therapeutic effect was assessed by the contrast-enhanced CT or MRI. When contrast enhancement was remained in the tumor, the treatment was repeated. The 28 evaluable lesions followed were with median 25 months in the term of the surveillance, and 9 tumors were treated by an additional session of RFA repeatedly, complete response (CR) was achieved in 12 out of 12 tumors (100%) with tumor maker normalization. On the other hand, 12 out of 16 tumors (75%) without marker normalization showed CR. All of the 24 tumors with tumor diameter of 30 mm or less achieved CR, and the tumor greater than 30 mm achieved no CR. Major complications included pneumothorax (n = 9) and hemato-thoraxes (n = 2), but no complications in surrounding organs. The chest drainage tube was required in 4 cases (36%). RFA might be an alternative therapeutic option of combined modality therapy as salvage therapy for post-chemotherapeutic metastatic germ cell tumors.
  • Y. Naya, A. Ochiai, J. Soh, A. Kawauchi, T. Miki
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH 20 6 574 - 577 2008年11月 [有り][無し]
     研究論文(学術雑誌) 
    Recently, the association between motorcycling and erectile dysfunction (ED) has been reported. Also, lower urinary tract symptoms (LUTS) were reported to be associated with ED. The aim of this study is to evaluate the association of ED with LUTS in motorcyclists. We investigated the prevalence and the status of ED using a 5-item version of the International Index of Erectile Function (IIEF-5) in 150 motorcyclists. ED was diagnosed when the IIEF-5 score was less than 17. The International Prostate Symptom Score (IPSS) was also applied, and the relationship between IIEF-5 and IPSS was evaluated. Of the 150 motorcyclists, 37 (25%) had ED, and 31 (21%) had moderate or severe symptoms of LUTS (IPSS >= 8). The IIEF-5 was significantly associated with the severity of IPSS (P = 0.002) and age (P<0.0001). The IIEF-5 was also significantly associated with the scores of both voiding (P<0.0001) and storage symptoms (P = 0.001). On stepwise logistic regression analysis, age and storage symptoms are independent risk factors for ED in motorcyclists. LUTS seemed to be associated with ED in motorcyclists.
  • Fujii H, Nakamura T, Mikami K, Okihara K, Mizutani Y, Kawauchi A, Miki T
    Hinyokika kiyo. Acta urologica Japonica 54 11 733 - 736 2008年11月 [有り][無し]
  • K. K. Gulia, E. Jodo, A. Kawauchi, T. Miki, Y. Kayama, H. N. Mallick, Y. Koyama
    Neuroscience 156 4 1064 - 1073 2008年10月 [有り][無し]
     研究論文(学術雑誌) 
    The effects of electrical stimulation to the septum on penile erections in rats were examined to clarify the mechanisms for regulation of erectile responses during different states of vigilance. Penile responses were assessed by changes in pressure in the corpus spongiosum of penis (CSP) and electromyography (EMG) of the bulbospongiosus (BS) muscle. In anesthetized and un-anesthetized rats, stimulation in and around the septum induced three erectile patterns 1) a Normal type response, which was indistinguishable from a spontaneous erection, characterized by a slow increase in CSP pressure with sharp CSP pressure peaks associated with BS muscle bursts, 2) Mixed type response, in which high frequency CSP pressure peaks were followed by a Normal type response, and 3) a Prolonged type response, evoked only in the anesthetized rat, consisting of a single sharp CSP peak followed by a slow increase in CSP pressure and a return to baseline with multiple subsequent events repeated for up to 960 s. In addition, a Micturition type response was also observed involving high frequency CSP pressure oscillations similar to the pressure pattern seen during spontaneous micturition. We found that erections were induced after stimulation to the lateral septum (LS), but not from the medial septum (MS). In anesthetized rats, a few responses were also obtained following stimulation of the horizontal limb of diagonal band (HDB). In un-anesthetized rats, responses were also induced from the HDB and the ventral limb of diagonal band (VDB) and the adjoining areas. The effective sites for eliciting erection during rapid eye movement (REM) sleep were located in the dorsal and intermediate parts of the LS, whereas the ventral part of the LS was the most effective site for eliciting erections during wakefulness. These results suggest a functional role for penile erection in the septum, and further suggest that subdivisions of the LS may have different roles in the regulation of penile erection during wakefulness and REM sleep. © 2008 IBRO.
  • Yoshio Naya, Akihiro Kawauchi, Kimihiko Yoneda, So Ushijima, Yasuyuki Naitoh, Jintetsu Soh, Yoshizo Ito, Yoichi Mizutani, Tsuneharu Miki
    UROLOGY 72 3 687 - 689 2008年09月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVES To evaluate. appropriate cooling methods in laparoscopic partial nephrectomy. METHODS Under general anesthesia, 21 porcine kidneys were exposed retroperitoneoscopically. Ice slush (500 g) was put into the retroperitoneal cavity after renal vascular clamping. Renal parenchymal temperature was measured by a thermometer. Seven kidneys were cooled only by ice slush (group I). In seven kidneys, 200 mL of 4 degrees C saline was infused around the kidney 45 minutes after vascular clamping (group II). In seven kidneys, 4 degrees C saline was irrigated continuously through a 5F ureteral catheter, which was inserted into the ureter (group III). RESULTS In group I, 21 minutes after vascular clamping, the lowest temperature achieved was 13.2 degrees C, and at 47 minutes the temperature exceeded 20 degrees C. In group II, the lowest temperature achieved was 13.0 degrees C 23 minutes after vascular clamping, and at 59 minutes the temperature exceeded 20 degrees C. In group III, the lowest temperature of 10.6 degrees C was achieved at 27 minutes, and at 79 minutes the temperature exceeded 20 degrees C. CONCLUSIONS In complicated cases of laparoscopic partial nephrectomy, cooling with both ice slush and ureteral catheter irrigation was thought to be effective. When the renal collecting system is opened, an additional infusion of cooled water may also be effective.
  • Kosuke Yamamoto, Yoichi Mizutani, Hiroyuki Nakanishi, Jun Fujiwara, Hirokazu Ishida, Daisuke Toiyama, Koichi Abe, Issei Hayashi, Koichi Okada, Akihiro Kawauchi, Masaaki Mizuno, Jun Yoshida, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF ONCOLOGY 33 3 565 - 571 2008年09月 [有り][無し]
     研究論文(学術雑誌) 
    Immunotherapy is one of the most effective treatments against metastatic renal cell carcinoma (RCC). However, the response rate is not high. Therefore, more effective therapies are necessary for patients with metastatic RCC. We previously reported oil the significant antitumor activity of cationic multilamellar liposome containing human interferon-beta (huIFN-beta) gene (IAB-1) against RCC. We then examined the antitumor effect of IAB-1 in combination with anticancer drugs against RCC. The cytotoxicity of IAB-1 alone, and in combination with anticancer drugs, cisplatin, adriamycin, 5-fluorouracil, gemcitabine, paclitaxel and irinotecan hydrochloride against the human RCC cell line NC65 was examined by the colorimetric method using tetrazolium salt. For the in vivo study, we used NC65 cells inoculated into the severe combined immunodeficiency mouse. The results showed that the in vitro combination therapy with IAB-1 and 5-FU was more cytotoxic than IAB-1 alone. However, synergistic cytotoxicity was not observed when combined with IAB-1 and other anticancer drugs. NC65 tumors transfected with TAB-1 in mice were smaller than those receiving an injection of empty liposome or the recombinant huIFN-beta protein. Treatment with IAB-1 in combination with 5-FU resulted in significant anticancer activity. IAB-1 enhanced the activity of thymidine phosphorylase (TP), which converts 5-FU to the active metabolite, FdUMP. In contrast, IAB-1 decreased the activity of thymidylate synthase (TS), which is a target enzyme of 5-FU. In conclusion, these findings indicate that a combination of IAB-1 and 5-FU may have enhanced antitumor activity against human RCC, suggesting its potential clinical application. The mechanism of enhanced cytotoxicity by combination therapy with IAB-1 and 5-FU may up-regulate TP activity and down-regulate TS activity.
  • Kazumi Kamoi, Koji Okihara, Atsushi Ochiai, Osamu Ukimura, Yoich Mizutani, Akihiro Kawauchi, Tsuneharu Miki
    ULTRASOUND IN MEDICINE AND BIOLOGY 34 7 1025 - 1032 2008年07月 [有り][無し]
     研究論文(学術雑誌) 
    The aim of this study is to evaluate the diagnostic performance of transrectal real-time elastography (TRTE) to differentiate benign from malignant prostatic lesions, with pathologic diagnosis obtained by prostatic needle biopsy. Conventional gray scale transrectal ultrasonography (TRUS) and power Doppler ultrasonography (PDUS) were performed in 107 men who had elevated serum prostate-specific antigen level >4 ng/mL or abnormal findings on digital rectal examination. For baseline TRUS and PDUS imaging, the suspicion of carcinoma was scored using previously proposed five-point subjective scale. For TRTE imaging, we used newly adopted five-point subjective scale based on the degree and distribution of strain in relation to hypoechoic area, which simultaneously displayed on B-mode image. All patients underwent transperineal systematic 8-cores biopsies, as well as up to four cores of targeted biopsy from suspicious area by TRUS, PDUS and/or TRTE. The samples were diagnosed pathologically and compared with the findings of TRUS, PDUS and TRTE. Prostate cancer was detected in 40 (37%) of 107 patients. When a cutoff point of 3 (displaying focal asymmetric lesion without strain not related to hypoechoic lesion) was used, TRTE had 68% sensitivity, 81% specificity and 76% accuracy. TRTE was comparable with PDUS (70% sensitivity, 75% specificity and 73% accuracy) and had significantly higher sensitivity than TRUS (68% vs. 50%, p = 0.027). Combination of TRTE with PDUS increased sensitivity to 78%. The detection rate of directed biopsy from suspicious area in either TRTE or PDUS (TRTE + PDUS-directed biopsy) was 29% (31/107) by patient and was comparable with systematic biopsy (31%, 33/107, p = 0.86), whereas the detection rate of TRTE + PDUS-directed biopsy by core (551111, 50%) was significantly higher than systematic biopsy (132/856, 15%, p < 0.0001). For assessing prostatic lesions, TRTE with B-mode image-based scoring had almost the same diagnostic performance as PDUS. Although TRTE + PDUS-directed biopsy detected comparable number of cancers with systematic biopsy, both techniques should be used supplementarily for minimizing the number of missing cancers. (E-mail: kamoi@koto.kpum.ac.jp) (C) 2008 World Federation for Ultrasound in Medicine & Biology.
  • Koji Okihara, Takumi Shiraishi, Osamu Ukimura, Yoichi Mizutani, Akihiro Kawauchi, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 13 3 239 - 243 2008年06月 [有り][無し]
     研究論文(学術雑誌) 
    Background. This study aimed to clarify characteristics of the diagnosis and treatment of prostate cancer in Japan. Methods. In September 2005, questionnaire surveys were mailed to Japanese urologists (response rate, 43%; 474/1090) who were listed as voting members (VMs) of the Japanese Urological Association (JUA); the questionnaire surveys were also mailed to professors and chairmen (PCs) of urology departments at Japanese national, public, and private universities who were also VMs of the JUA (response rate, 76%; 68/90). The questionnaires asked about beliefs and practices regarding prostate cancer management. Results. The answers of the VMs and PCs to the questionnaire were very similar. About 60% of these urologists answered that they did not set an age limit for prostate-specific antigen (PSA) testing, and about 40% answered that they did not set an age limit for prostate needle biopsy in individuals with an intermediately elevated PSA level. The age limit for radical prostatectomy (RP) was set at 75 years by 69% (322/470) of the VMs and 66% (45/68) of the PCs. The order of priority of factors considered for the selection of RP for early prostate cancer was radicality, including tumor grade (mean, 1.97); patient's wish for radical surgery (mean, 2.47); comorbidity (mean, 2.72); and age (mean, 2.81). Conclusion. There are trends in diagnostic and therapeutic principles for prostate cancer which are characteristic of Japan, and these trends are associated with the recent rapid extension of life expectancy in that country.
  • Juan Carlos Toledo Salas, Hiroshi Iwasaki, Eiichi Jodo, Markus H. Schmidt, Akihiro Kawauchi, Tsuneharu Miki, Yukihiko Kayama, Manabu Otsuki, Yoshimasa Koyama
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 294 1 R102 - R111 2008年01月 [有り][無し]
     研究論文(学術雑誌) 
    The cholinergic neurons in the laterodorsal tegmental nucleus (LDT) play a crucial role in the regulation of rapid eye movement (REM) sleep. Because penile erection occurs during REM sleep, the involvement of the LDT in penile erection was examined in unanesthetized head-restrained rats. To detect penile erection, corpus spongiosum of the penis (CSP) pressure was measured through a telemetric device with simultaneous bulbospongiosum (BS) muscle EMG recording through stainless wires. Electrical stimulation in and around the LDT induced the following three CSP pressure patterns: 1) a full erection pattern indistinguishable from the nonevoked or spontaneous erection, characterized by a slow increase in CSP pressure with additional sharp CSP peaks associated with BS muscle bursts, 2) a muscular pattern characterized by sharp CSP pressure peaks but in the absence of a vascular component, i. e., without an increase in baseline CSP pressure, and 3) a mixed-type response characterized by high-frequency CSP pressure peaks followed by a full erection response. Full erections were evoked in and around the LDT, including more medially and ventrally. The sites for inducing mixed-type events were intermingled with the sites that triggered full erections in the anterior half of the LDT, whereas they were separated in the posterior half. The sites for muscular responses were lateral to the sites for full erections. Finally, a CSP pressure response identical to micturition was evoked in and around the Barrington's nucleus and in the dorsal raphe nucleus. These results suggest that the LDT and surrounding region are involved in the regulation of penile erection. Moreover, different anatomical areas in the mesopontine tegmentum may have specific roles in the regulation of penile erection and micturition.
  • Jintetsu Soh, Masato Katsuyama, So Ushijima, Yoichi Mizutani, Akihiro Kawauchi, Chihiro Yabe-Nishimura, Tsuneharu Miki
    UROLOGY 70 5 1019 - 1023 2007年11月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVES Diabetes-induced erectile dysfunction (ED) is assumed to result from neurovascular abnormalities. However, the entire picture of the molecular mechanisms underlying ED has not yet been clarified. To elucidate the possible elements involved in ED in diabetes mellitus, we performed broad-scale gene expression profiling using cDNA array in the penis of streptozotocin-induced diabetic rats. METHODS Northern blot analysis was performed to examine the course of the mRNA expression encoded by the identified gene. Immunohistochemistry was performed to identify the Cellular localization of the encoded protein. RESULTS Of the genes investigated, the expression level of insulin-like growth factor binding protein 3 (IGFBP-3) was greatly increased at 12 weeks after streptozotocin treatment. The levels of ErbB3 epidermal growth factor receptor-related proto-oncogene, G1/S-specific cyclin D2, hepatic neutral cholesteryl ester hydrolase precursor, UDP-galactose ceramide galactosyltransferase, and serine protease RNK-Met-1 were markedly decreased. Increased levels of IGFBP-3 mRNA were demonstrated as early as 2 weeks after induction of hyperglycemia. Increased IGFBP-3 protein was localized to the epithelium of the urethral penile endothelium, and smooth muscle in the corpus cavernosum. Significant depletion of the smooth Muscle density relative to the connective tissue was first observed in the penis of the 8-week diabetic rats, and a significant reduction in the intracavernous pressure was demonstrated only at 12 weeks after the induction of hyperglycemia. CONCLUSIONS These results suggest that the increased expression of IGFBP-3 during hyperglycemia might play an important role in the development of ED.
  • Masakatsu Oishi, Koji Okihara, Yoichiro Maeda, Hidekazu Tahara, Soh Ushijima, Soh Jintetsu, Kimihiko Yoneda, Akihiro Kawauchi, Tsuneharu Miki
    Acta Urologica Japonica 53 9 661 - 663 2007年09月 [有り][無し]
     研究論文(学術雑誌) 
    Subcapsral prostatectomy was performed in a 75-year-old male, with the diagnosis of benign prostatic hyperplasia. Total prostate volume was 105 ml by transrectal ultrasonography (TRUS) and the excised prostate weighed in 90 g. After the surgery, he recovered from urinary disturbance once, but, he again complained of severe dysuria 12 days after the surgery. With the aim of non-invasive examination, we performed TRUS at voiding. Urethral stricture was definitely diagnosed using TRUS during micturition. Thus voiding TRUS was very effective in diagnosing urethral stricture.
  • Hiroo Nakauchi, Ken-ichi Matsuda, Ikuo Ochiai, Akihiro Kawauchi, Yoichi Mizutani, Tsuneharu Miki, Mitsuhiro Kawata
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 55 6 535 - 544 2007年06月 [有り][無し]
     研究論文(学術雑誌) 
    Androgen has been shown to promote the proliferation of prostate cancer through the action of the androgen receptor (AR). Mutation (T877A) of the AIR gene found in an androgen-sensitive prostate cancer cell line, LNCaP, has been postulated to be involved in hypersensitivity and loss of specificity for androgen. In the present study, trafficking of AIR and AR (T877A) in living prostate and non-prostate cancer cell lines under high and low concentrations of androgen and antiandrogen was investigated by tagging green fluorescent protein (GFP) to the receptors. In the presence of a high concentration of androgen, AR-GFP localized in the nucleus by forming discrete clusters in all cell lines. AR (T877A)-GFP was also translocated to the nucleus in LNCaP and COS-1 cells by the addition of a high concentration of androgen. In contrast, in the presence of a low concentration of androgen, the translocation of AR-GFP and AIR (T877A)-GFP was observed in LNCaP cells, but not in COS-1 cells. Upon the addition of antiandrogen, AR-GFP was translocated to the nucleus but did not form subnuclear foci in both COS-1 and LNCaP cells, whereas AR (T877A)-GFP in both cells was translocated to the nucleus with subnuclear foci. The present study demonstrates the differential response of nuclear trafficking of AIR and its mutant in prostate cancer cell lines and COS cells, and the subcellular and subnuclear compartmentalization provide important information on the sensitivity of the AR mutation.
  • Yongnan Li, Yoichi Mizutani, Takumi Shiraishi, Koji Okihara, Osamu Ukimura, Akihiro Kawauchi, Norio Nonomura, Masakazu Fukushima, Toshiyuki Sakai, Tsuneharu Miki
    UROLOGY 69 5 988 - 995 2007年05月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives Thymidylate synthase (TS), a key enzyme in DNA synthesis, is overexpressed in a variety of cancer cells. 5-Fluorouracil (5-FU), an anticancer agent used clinically against various cancers, including prostate cancer, inhibits DNA synthesis by binding TS. In this study, we investigated the expression of TS in prostate cancer and its prognostic significance. Its association with the expression of dihydropyrimidine dehydrogenase (DPD), a principal enzyme in the degradation of 5-FU and pyrimidine nucleotides, was also examined. Methods Fifty-two prostatic tissue specimens were obtained from patients who had undergone radical prostatectomy for prostate cancer without neoadjuvant hormonal therapy. We analyzed the cancerous tissue and normal prostatic tissue specimens for TS expression using immunohistochemistry. Results TS was expressed at greater levels in the prostate cancer specimens than in the normal prostatic tissue specimens. The patients with prostate cancer with negative TS expression had a longer postoperative recurrence-free rate than did those with positive expression during the 5 years of follow-up. TS expression was significantly decreased in patients who received neoadjuvant hormonal therapy. No relationship was found between the expression of TS and DPD. Patients with prostate cancer with either negative TS or DPD expression had a significantly longer postoperative disease-free rate than those with positive expression of both during the 5 years of follow-up. Conclusions The results of the present study have shown for the first time that TS expression could be a prognostic marker for patients with prostate cancer undergoing radical prostatectomy. In addition, the combination of TS and DPD expression might also be helpful for the prediction of the prognosis of patients with prostate cancer.
  • Hui Wang, Yoshiyuki Tanaka, Hideo Seki, Eiich Jodo, Yukihiko Kayama, Akihiro Kawauchi, Tsuneharu Miki, Manabu Otsuki, Yoshimasa Koyama
    NEUROSCIENCE RESEARCH 57 4 531 - 537 2007年04月 [有り][無し]
     研究論文(学術雑誌) 
    The effects of acupuncture stimulation to the sacral segment on electroencephalograms (EEGs) and activity of locus coeruleus (LC) neurons were examined in urethane-anesthetized rats. In 71 of 112 trials, when EEGs displayed small amplitude and high frequency, stimulation to the sacral segment-induced large amplitude and slow EEGs with a latency of < 450 s and duration ranged from 32 s to > 42 min. Stimulus-induced EEGs comprised significant increases in delta power and significant decreases in theta and beta powers. After intraperitoneal administration of bicuculline, stimulation to the sacral segment failed to induce changes in EEG pattern. Firing rate of noradrenergic LC neurons decreased significantly from 2.9 +/- 1.5 to 1.1 +/- 0.8 Hz (n = 11, p < 0.001). Decreased neuronal activity exhibited close relationships with increased EEG amplitude. These results suggest that acupuncture stimulation to the sacral segment changes the state of animals from light anesthesia to deep anesthesia, and that this change is mediated by GABAergic systems suppressing the activity of noradrenergic LC neurons. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
  • Yoichi Mizutani, Hiroyuki Nakanishi, Yong Nan Li, Hiroki Matsubara, Kosuke Yamamoto, Nodoka Sato, Takumi Shiraishi, Terukazu Nakamura, Kazuya Mikami, Koji Okihara, Natsuki Takaha, Osamu Ukimura, Akihro Kawauchi, Norio Nonomura, Benjamin Bonavida, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF ONCOLOGY 30 4 919 - 925 2007年04月 [有り][無し]
     研究論文(学術雑誌) 
    X-linked inhibitor of apoptosis protein (XIAP) is the most potent. caspase-inhibitory IAP family member and a negative regulator of various apoptotic stimuli. Thus, XIAP overexpression in cancer cells may select for tumor cell survival following various cytotoxic therapeutic modalities. The anatomical staging system in renal cell carcinoma (RCC) currently provides good prognostic information, albeit insufficient. We hypothesize that overexpression of XIAP in RCC may serve as a molecular prognostic marker in RCC and improve the staging of RCC. This study examined the protein level of XIAP in lysates from surgical specimens of 109 patients with RCC and 109 normal kidney specimens from the same patients. The level of XIAP expression was quantified by Western blot analysis using non-fixed fresh frozen tissues of RCCs and normal kidneys. Results indicated that the mean level of XIAP expression was higher in RCC compared to autologous normal kidney, and the XIAP expression level in 38/109 (35%) of RCC was more than 2-fold greater than that in normal kidney tissue. In Stage I/II RCC, the mean XIAP expression level was almost identical to that detected in normal kidney, whereas XIAP expression in Stage III/IV was 2.5-fold higher than that in Stage I/II RCC. Levels of XIAP expression also correlated with the grade of RCC. Patients with RCC with low XIAP expression had a longer postoperative disease-specific survival as compared to those with high expression in the 5-year follow-up. The suggested role of XIAP in the regulation of resistance in apoptosis was examined in vitro following treatment of RCC cell lines with XIAP antisense oligonucleotide and the cells were sensitized to both Fas-mediated and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. The present study demonstrates at the protein level that XIAP is overexpressed in RCC, and that high XIAP expression in RCC predicted a worse prognosis. In addition, XIAP antisense oligonucleotide sensitized RCC to Fas/TRAIL-induced apoptosis. These results suggest that XIAP expression in RCC may be used as a prognostic parameter, and that downregulation or inhibition of XIAP expression in RCC may reverse immune resistance.
  • Yongnan Li, Yoichi Mizutani, Takumi Shiraishi, Terukazu Nakamura, Kazuya Mikami, Natsuki Takaha, Koji Okihara, Akihiro Kawauchi, Toshiyuki Sakai, Tsuneharu Miki
    BJU INTERNATIONAL 99 3 663 - 668 2007年03月 [有り][無し]
     研究論文(学術雑誌) 
    To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. In all, 44 prostate tissue specimens were obtained from men who had a radical prostatectomy alone for prostate cancer, and 38 specimens from men who had had neoadjuvant hormonal therapy. We analysed the cancerous tissue and normal prostate tissue for DPD expression using immunohistochemistry, and determined its prognostic significance. In cultured human prostate cancer lines (DU145 and LNCaP), we compared the cytotoxicity of 5-FU/CDHP with that of 5-FU alone. Finally, in experiments on immunodeficient mice, we studied the effect of oral administration of tegafur, a pro-drug for 5-FU, with or without CDHP on the growth of tumours introduced by injection of DU145 cells. The expression of DPD was significantly higher in cancerous than normal prostate tissue; 36 of 44 (82%) specimens of prostate cancer expressed DPD, whereas only 25 of 44 (57%) specimens of normal prostate tissue expressed DPD. For men with prostate cancer who had radical prostatectomy alone, men with negative DPD expression tended to have a longer recurrence-free survival than those with positive expression; there were no recurrences in men with prostate cancer and negative DPD expression in the 5-year follow-up. DPD expression was significantly lower in men with prostate cancer who received neoadjuvant hormonal therapy. In vitro treatment of human prostate cancer cell lines with 5-FU/CDHP showed more cytotoxicity than with 5-FU treatment alone. Finally, DU145 tumours in mice treated with tegafur and CDHP were significantly smaller than in mice given tegafur alone. The present study showed that DPD expression is elevated in prostate cancer, and indicate that DPD inhibitors might enhance the antitumour activity of 5-FU against prostate cancer.
  • Koji Okihara, Osamu Ukimura, Noriyuki Kanemitsu, Yoichi Mizutani, Akihiro Kawauchi, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 14 2 128 - 132 2007年02月 [有り][無し]
     研究論文(学術雑誌) 
    Background: To confirm the effectiveness of alternative antiandrogen therapy (AAT) in Japanese patients with prostate cancer relapse after first-line hormonal therapy. Methods: A total of 80 patients who had successive serum prostate-specific antigen (PSA) progression after first-line hormonal therapy (luteinizing hormone-releasing hormone agonist alone: 21 cases; combined antiandrogen blockade therapy: 59 cases) were enrolled. We evaluated the positive ratio of antiandrogen withdrawal syndrome (AWS), the PSA responses with second- and third-line AAT, and cause-specific survival in terms of the effectiveness of AAT. Results: The overall positive AWS ratio after first-line therapy was 33%, while that after second-line therapy was 7%. There was no correlation between the first-line PSA response and the positive AWS. Of the 10 positive and the 20 negative AWS cases, secondary antiandrogen administration was effective in 50% and 60% of cases, respectively. The positive PSA responders at second- and third-line therapy were 51% and 13%, respectively. For second-line therapy, the effective rates from steroidal to non-steroidal, from non-steroidal to non-steroidal antiandrogen, and from non-steroidal to steroidal were 83%, 43%, and 14%, respectively. The cause-specific survival of the second-line responders was significantly better than that of the non-responders. Conclusion: There was a substantial number of patients who found second-line AAT to be modestly effective. Flutamide was effective as an alternative antiandrogen for the patients' relapse treatment with bicalutamide in Japanese men.
  • Akihiro Kawauchi, Kimihiko Yoneda, Akira Fujito, Koji Okihara, Jintetsu Soh, Yasuyuki Naitoh, Yoichi Mizutani, Tsuneharu Miki
    UROLOGY 69 1 53 - 56 2007年01月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVES To evaluate and compare the oncologic outcome of hand-assisted retroperitoneoscopic radical nephrectomy (HALS) with that of open radical nephrectomy. METHODS The clinical and follow-up data of 123 patients with localized renal cell carcinoma who underwent HALS were retrospectively compared with those of 70 patients who underwent open radical nephrectomy. RESULTS No significant differences were found in operating time, complication rates, or transfusion rates between the HALS and open groups. The estimated blood loss was significantly less in the HALS group. The median follow-up period was 41.0 months for the HALS group, significantly shorter than that for the open group (74.5 months). The 3 and 5-year disease-free survival rate for the HALS and open groups was 94% and 92% and 93% and 91%, respectively. The 3 and 5-year cancer-specific survival rate for the HALS and open groups was 96% and 92% and 98% and 94%, respectively. No significant differences were found in the disease-free and cancer-specific survival rates between the two groups. In the HALS group, no significant differences were found in the disease-free survival rate between those undergoing surgery by less-experienced surgeons who had performed laparoscopic nephrectomy on 10 cases or less and those undergoing surgery by more experienced surgeons. CONCLUSIONS The oncologic outcome of HALS did not differ much from that of the open approach. Also, the experience of the surgeon did not affect the oncologic outcome. However, extended follow-up is necessary to assess the true oncologic efficacy of HALS. (c) 2007 Elsevier Inc.
  • Mitsuhiko Inaba, Osamu Ukimura, Takeshi Yaoi, Akihiro Kawauchi, Shinji Fushiki, Tsuneharu Miki
    UROLOGIA INTERNATIONALIS 78 3 270 - 277 2007年 [有り][無し]
     研究論文(学術雑誌) 
    The objective of the study was to evaluate possible changes of the gene expression and localization of the enzymes, heme oxygenase and nitric oxide synthase (NOS), with reference to increase of collagen type III in response to the partial obstruction of the bladder. Following initial obstruction, whole rat bladders were removed for real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Real-time RT-PCR demonstrated significantly enhanced expression of HO (p < 0.01) and collagen type III (p < 0.001) gene on postoperative day 14. Enhanced expression of NOS gene was seen only on postoperative day 4 (p < 0.01). Immunohistochemistry revealed that immunoreactivity to HO-1 had much in common in neural cells and fibers, although immunoreactivity to HO-2 and iNOS was relatively weak. This study suggested gene expression of HO, especially HO-1, was more dramatically changed than NOS, and was upregulated simultaneously with increase of collagen type III after obstruction. HO systems could be involved in the pathogenesis of bladder dysfunction related to increase of collagen type III after obstruction. Copyright (c) 2007 S. Karger AG, Basel
  • A. Kawauchi, Y. Inoue, T. Hashimoto, N. Tachibana, S. Shirakawa, Y. Mizutani, T. Ono, T. Miki
    Clinical Nephrology 66 6 440 - 446 2006年12月 [有り][無し]
     研究論文(学術雑誌) 
    Aims: To compare clinical data, sleep quality nd health-related quality of life (HRQOL) with and without RLS in HD patients. Materials and methods: The international RLS study group diagnosis questionnaire was completed by 228 HD patients. The Pittsburg Sleep Quality Index (PSQI) for the evaluation of sleep quality and the Kidney Disease Quality of Life (KDQOL-SF) for the analysis of HRQOL were also used. Results: 53 (23%) patients were diagnosed as RLS. Age and age at the initiation of HD were significantly younger in the RLS group. Serum calcium concentration (Ca) was significantly higher in the RLS group. Sleep quality evaluated by PSQI was significantly lower in the RLS group. In SF-36 domains of KDQOL-SF, bodily pain, general health perceptions, vitality, role functioning emotional, mental health and mental component score were significantly lower in the RLS group. In kidney targeted scales of KDQOL-SF, symptoms/problems, burden of kidney disease, cognitive function, quality of social interaction, sleep and patient satisfaction were significantly lower in the RLS group. Conclusion: High Ca was possibly connected to the pathophysiology of RLS which impaired sleep quality as well as HRQOL including mental health and many kidney disease related scales. ©2006 Dustri-Verlag Dr. K. Feistle.
  • Akihiro Kawauchi, Yasuyuki Naitoh, Kimihiko Yoneda, Jintetsu Soh, Hideo Seki, Koji Okihara, Yoichi Mizutani, Tsuneharu Miki
    Journal of Pediatric Urology 2 6 579 - 582 2006年12月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To clarify refractory enuresis related to alarm therapy, we evaluated the possibility of the prediction of refractory cases, the effectiveness of alarm therapy for cases refractory to pharmacotherapy and the prognosis of non-responders to alarm therapy. Methods: First, the effectiveness of alarm therapy in 55 monosymptomatic patients and 29 with daytime symptoms was evaluated. Next, another 37 patients with monosymptomatic nocturnal enuresis were treated by enuresis alarm. Possible predictive factors of therapeutic effect were compared between the 'effective' patients and the 'no-change' patients. The effectiveness of alarm monotherapy for non-responders to pharmacotherapy was evaluated. The prognosis of non-responders to alarm therapy at 6 months was also studied. Results: In the 55 monosymptomatic patients, the total effective rate at 3 months was 59%, while that in the 29 patients with daytime symptoms was only 38%. In the 37 patients with monosymptomatic nocturnal enuresis, there were no significant differences between the effective patients and the no-change patients in possible predictive factors. Even in patients who had previously had pharmacotherapy, the effective rate of alarm therapy was 64%, while it was 57% in patients without previous therapy. The effective rates of DDAVP and imipramine for non-responders to alarm monotherapy were only 25% and 33%, respectively. Conclusion: Daytime symptoms were the only predictive factor of alarm therapy. Alarm therapy was effective for cases refractory to pharmacotherapy. Non-responders to alarm therapy were also refractory to pharmacotherapy. © 2005 Journal of Pediatric Urology Company.
  • Hiroki Matsubara, Yoichi Mizutani, Fumiya Hongo, Hiroyuki Nakanishi, Yasunori Kimura, So Ushijima, Akihiro Kawauchi, Takahiro Tamura, Tsuneaki Sakata, Tsuneharu Miki
    MOLECULAR CANCER THERAPEUTICS 5 9 2165 - 2171 2006年09月 [有り][無し]
     研究論文(学術雑誌) 
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells. However, TRAIL is not toxic against most normal cells. We have accordingly examined by in vivo electroporation whether TRAIL induces apoptosis in renal cell carcinoma. In addition, combination treatment with TRAIL and 5-fluorouracil (5-FU) against renal cell carcinoma was also investigated. The NC65 renal cell carcinoma line was used as a target. pCAGGS TRAIL was injected into the NC65 tumors in the right flanks of severe combined immunodeficient mice. Tumors were pulsed with the CUY21 electroporator. Electroporation was done once on day 0 or thrice on days 0, 2, and 4. Apoptosis was determined by terminal deoxyribonucleotide transferase-mediated nick-end labeling assay. When TRAIL gene therapy using in vivo i.t. electroporation was done once only, the growth of NC65 tumors was not inhibited. However, when TRAIL gene therapy was done thrice, growth suppression of the NC65 tumors was observed. Transfection of the TRAIL gene by in vivo electroporation induced apoptosis in NC65 tumors. When NC65 cells were treated with TRAIL gene therapy in combination with 5-FU, stronger growth suppression was obtained. TRAIL gene therapy did not induce liver dysfunction in severe combined immunodeficient mice. This study shows that TRAIL gene therapy induced growth suppression and apoptosis in NC65 tumors without severe side effects, and that combination treatment of NC65 cells with TRAIL gene therapy and 5-FU resulted in higher antitumor activity. These findings suggest that TRAIL gene therapy and/or 5-FU may be effective against renal cell carcinoma without harmful toxic effects.
  • So Ushijima, Osamu Ukimura, Koji Okihara, Yoichi Mizutani, Akihiro Kawauchi, Tsuneharu Miki
    JOURNAL OF UROLOGY 176 2 665 - 671 2006年08月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: We assessed patient quality of life specific to each of the 7 items on the International Prostate Symptom Score, as evaluated with a novel visual analog scale questionnaire. Materials and Methods: A total of 246 male patients with a chief complaint of lower urinary tract symptom were asked to complete the International Prostate Symptom Score and visual analog scale questionnaires to assess bother or satisfaction regarding patient quality of life specific to each of the 7 items on the International Prostate Symptom Score. Results: An item with the maximum visual analog scale measure matched the chief complaint in 169 patients (69%). In contrast, the chief complaint failed to match to an item with the most severe International Prostate Symptom Score in 104 patients (42%) (p = 0.012). Multiple regression analysis to define the best predictor of International Prostate Symptom Score quality of life score of the 14 items, including International Prostate Symptom Score and visual analog scale, revealed that the best predictor was the visual analog scale measure for nocturia (p = 0.0003), followed by visual analog scale measures for frequency (p = 0.0004) and incomplete emptying (p = 0.01). After a-blocker treatment improvement in the visual analog scale measure for the chief complaint correlated better with improvement in the International Prostate Symptom Score quality of life score than the change in International Prostate Symptom Score. The overall test-retest correlation for the visual analog scale questionnaire in 55 healthy elderly men and 44 patients with lower urinary tract symptoms was 0.772 and 0.742, respectively (p < 0.00001). Conclusions: The novel visual analog scale measure of quality of life specific to each of the 7 items on the International Prostate Symptom Score has a significant impact on identifying the patient chief complaint as well as on patient specific quality of life. Our study supports the concomitant use of the International Prostate Symptom Score and visual analog scale questionnaires.
  • Hideaki Itoh, Munekado Kojima, Koji Okihara, Osamu Ukimura, So Ushijima, Akihiro Kawauchi, Tsuneharu Miki
    INTERNATIONAL JOURNAL OF UROLOGY 13 8 1058 - 1065 2006年08月 [有り][無し]
     研究論文(学術雑誌) 
    Aims: The aim of the present paper is to elucidate the possible involvement of time-dependent parameters as obtained by uroflowmetry in the manifestation of lower urinary tract symptoms (LUTS) in elderly patients. Methods: Using simple and multiple regression analyses, the correlation of the International Prostate Symptom Score (IPSS) with objective parameters including age, postvoid residual, uroflowmetry and transrectal ultrasonic measurements of the prostate was analyzed in 206 male patients (average age of 68.0 +/- 7.4 years) who visited our outpatient clinic complaining of LUTS. Results: In the 206 patients, the mean maximum flow rate was 12.2 mL/s (13.7 mL/s in mild, 11.9 mL/s in moderate, and 11.2 mL/s in severe IPSS total score) and average ow rate was 4.4 mL/s (5.4 mL/s in mild, 4.3 mL/s in moderate, and 3.5 mL/s in severe IPSS total score). Simple regression analyses demonstrated that age, voiding time, and average and maximum ow rates correlate significantly with symptom scores. In particular, relatively strong relationships were found between average ow rate and scores of intermittency, weak stream and total and voiding symptoms scores. Serum prostate specific antigen level, postvoid residual and prostatic ultrasonic measurements did not show a significant correlation with symptom scores. Multiple regression analyses revealed age and average flow rate to be independent determinants for symptom scores. Conclusion: These results suggest that the time-dependent function in micturition interferes in the manifestation of LUTS in elderly men who have borderline or pathologic maximum flow rate. When evaluating uroflowmetry in elderly male patients with LUTS, attention should be paid to time-dependent parameters such as voiding time and average flow rate.
  • A. Ochiai, Y. Naya, J. Soh, Y. Ishida, S. Ushijima, Y. Mizutani, A. Kawauchi, T. Miki
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH 18 4 396 - 399 2006年07月 [有り][無し]
     研究論文(学術雑誌) 
    The aim of the present study was to evaluate the relationship between motorcycling and erectile dysfunction (ED). We investigated the relationship between motorcycling and erectile function using the 5-items version of the International Index of Erectile Function (IIEF5) in 234 motorcyclists (response rate 75%) and 752 healthy controls (response rate 66%). In all, 161 (69%) of 234 motorcyclists were diagnosed as ED based on IIEF5. The prevalence of ED in the motorcycle group increased by age as: 58, 63, 76 and 93%, for motorcyclists in 20-29, 30-39, 40-49 and 50-59 years, respectively. There was a significant difference in the prevalence of ED between the motorcycle group and the control group in all age groups. On stepwise logistic regression analysis, motorcycling was the strongest risk factor for ED. Although the severity of ED in motorcyclists was not so severe, motorcycling may be one of risk factors for ED.
  • Naitoh Y, Kawauchi A, Miki T
    Nihon rinsho. Japanese journal of clinical medicine Suppl 2 313 - 316 2006年06月 [有り][無し]
  • J Soh, Y Naya, S Ushijima, Y Naitoh, A Ochiai, Y Mizutani, A Kawauchi, T Miki, T Fujiwara
    ARCHIVES OF ANDROLOGY 52 3 163 - 168 2006年05月 [有り][無し]
     研究論文(学術雑誌) 
    Sildenafil is most effective in men with mild-to-moderate ED, but not severe ED in Japan. In order to evaluate the efficacy of sildenafil, we conducted the present study using the AVSS test by the RigiScan Plus. The subjects were 56 patients (age: 34-82 years, mean: 60.5 years) with ED. The IIEF5 questionnaire and the AVSS test were conducted before and after administration of sildenafil. The penile rigidity could not be measured in 19 patients. Of these 19, sildenafil was effective in 7 and not effective in 12. The 7 cases in whom sildenafil was effective were all false-negatives. The sensitivity of sildenafil was 84%, and its specificity was 100%. This study suggests that the AVSS test by RigiScan Plus can objectively evaluate the efficacy of sildenafil, and shows potential for predicting that efficacy.
  • Koji Yoshimura, Shingo Yamamoto, Akihiro Kawauchi, Mikio Ito, Shuichi Nakagawa, Yasuki Horii, Yoshihito Higashi, Yasuhiko Okamura, Yoshihiro Yamazoe, Fuminori Nin, Susumu Inoue, Yuji Kihara, Mitsuo Nonomura, Shuichi Hida, Hiroshi Okuno, Akira Okasho, Kazumi Kamoi, Mikio Maekawa, Tomohito Kitamori, Tadashi Aoki, Toshiyuki Kamoto, Masahiro Nakao, Osamu Ogawa, Tsuneharu Miki, Hiroshi Ohe, Tetsuro Muratani, Tetsuro Matsumoto
    Acta Urologica Japonica 52 4 265 - 270 2006年04月 [有り][無し]
     研究論文(学術雑誌) 
    The data of sexually transmitted urethritis in males have been collected at 24 institutes in Kyoto Prefecture since October, 2002. The data collected from January to December in 2004 are summarized herein. A total of 1,275 patients were diagnosed with urethritis during this period. Microbiological examinations isolated Neisseria gonorrhoeae alone in 368 (29%), Chlamydia tracomatis alone in 336 (26%), both in 85 (7%), and others in 453 (36%). Male patients under 20 years old tended to have Chlamydial urethritis, alone or combined with gonococcal infection, and had a predominant infectious source, a non-commercial-sexual-worker female partner, suggesting a profound problem in sexual life of adolescents. The urologist preferred to use quinolones as the first therapeutic modality against male urethritis. However, drug resistance of N. gonorrhoeae, especially against quinolones, has rapidly progressed, which was also observed by a sensitivity examination test. Antibiotics should be used adequately against male urethrits according to the recent guidelines.
  • N Hirahara, O Ukimura, S Ushijima, Y Yamada, K Okihara, A Kawauchi, S Miki
    JOURNAL OF ULTRASOUND IN MEDICINE 25 3 307 - 313 2006年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objective. The purpose of this study was to describe initial applications of 4-dimensional ultrasonography (4DUS) for visualizing dynamic change in 3-dimensional (3D) bladder shape as well as for analyzing intravesical volume and diameters during voiding. Methods. In 15 healthy volunteers and 5 patients with lower urinary tract symptoms, 4DUS images of the bladder during voiding were obtained by transabdominal 4DUS and compared with the outcome of uroflowmetry. Changes of intravesical volume as well as diameters in axial, coronal, and sagittal planes were measured and analyzed in comparison with uroflow data. Results. Dynamic 3D visualization of the bladder shape was feasible in all 20 men. Multiplanar display of 4DUS showed dynamic 3D images of the bladder during voiding to be simultaneously visualized in the axial, coronal, and sagittal planes. The change and decrease rate in intravesical volume calculated by 4DUS data had significant correlation with the average flow rate (P =.02) and the maximum flow rate (P =.04), respectively. Among the 3 diameters, the change of coronal diameter was significantly most correlated with change of the intravesical volume (P < .0001). The change in coronal diameter, which was observed in patients with urinary disturbance, had a significant difference compared with those observed in control subjects (P = .01). Conclusions. Monitoring of voiding with 4DUS was feasible in healthy men and patients with lower urinary tract symptoms. Four-dimensional ultrasonography has the potential to be a novel noninvasive urodynamic modality to visualize dynamically the lower urinary tract during voiding and to improve pathophysiologic understanding of voiding.
  • K Okihara, O Ukimura, T Nakamura, S Ushijima, Y Mizutani, A Kawauchi, Y Naya, M Kojima, T Miki
    UROLOGY 67 2 328 - 332 2006年02月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To compare the distribution of total and complexed prostate-specific antigen (cPSA) in men with and without prostate cancer with another studied population and to ascertain whether cPSA could enhance the detection of prostate cancer in Japanese men. Methods. A total of 760 men whose serum total PSA (tPSA) values ranged from 1.0 to 100 ng/mL were enrolled. Serum samples for tPSA and cPSA (ADVIA Centaur) were obtained in all cases. The area under the curve was calculated for comparison of the tPSA and cPSA values. We calculated the number of cancers missed and false-positive results at various cutoff values of cPSA compared with the conventional tPSA threshold of 4.0 ng/mL. Results. Prostate cancer was detected in 268 (35.3%) of 760 patients. cPSA was greater than 8.3 ng/mL (equivalent to 10.0 ng/mL tPSA) in 46.6% of the men with cancer. The area under the curve for cPSA (0.741) was significantly better than that for tPSA (0.721, P<0.001). At a sensitivity of 85% to 95%, significant differences were found in the corresponding specificity between tPSA and cPSA. cPSA at a 3.0-ng/mL threshold detected an identical number of cancers as a tPSA cutoff of 4.0 ng/mL; however, it decreased the false-positive results by 28 cases. Conclusions. To our knowledge, this is the first report of the distribution of cPSA in Japanese men using a urologic referral population. cPSA can be an alternative to tPSA as the first screening test. A substantial number of men in Japan with prostate cancer are currently diagnosed with a tPSA value greater than 10.0 ng/mL.
  • T Miki, K Okihara, O Ukimura, S Usijima, K Yoneda, Y Mizutani, A Kawauchi, M Koga, M Takeyama
    UROLOGY 67 2 410 - 412 2006年02月 [有り][無し]
     研究論文(学術雑誌) 
    Introduction. We used a running suture method for vesicourethral anastomosis in patients undergoing minilaparotomy radical retropubic prostatectomy. Technical Considerations. The vesicourethral anastomosis using a single knot at the 6:30-o'clock position is created with two steps of semicircular running suture. A total of 2 1 consecutive patients underwent this running suture method using the Endostitch in the hands of a single surgeon (T.M.) between March and November 2004. The running suture procedure was completed in 15 minutes on average. After surgery, no urinary leakage at the anastomotic site was found. Satisfactory continence was achieved in the short term in 100% (0 to 1 pad per day) of cases. However, dilation at the anastomosis using a metal dilator was required in 2 patients immediately after surgery. Conclusions. The running suture method is considered a feasible alternative in minilaparotomy radical retropubic prostatectomy.
  • Mizutani Y, Nakamura T, Nomoto T, Kawauchi A, Miki T
    Gan to kagaku ryoho. Cancer & chemotherapy 33 2 183 - 187 2006年02月 [有り][無し]
  • Jintetsu Soh, Y. Naya, S. Ushijima, Y. Naitoh, A. Ochiai, Y. Mizutani, A. Kawauchi, T. Fujiwara, T. Miki
    Systems Biology in Reproductive Medicine 52 3 163 - 168 2006年 [有り][無し]
     研究論文(学術雑誌) 
    Sildenafil is most effective in men with mild-to-moderate ED, but not severe ED in Japan. In order to evaluate the efficacy of sildenafil, we conducted the present study using the AVSS test by the RigiScan Plus. The subjects were 56 patients (age: 34-82 years, mean: 60.5 years) with ED. The IIEF5 questionnaire and the AVSS test were conducted before and after administration of sildenafil. The penile rigidity could not be measured in 19 patients. Of these 19, sildenafil was effective in 7 and not effective in 12. The 7 cases in whom sildenafil was effective were all false-negatives. The sensitivity of sildenafil was 84%, and its specificity was 100%. This study suggests that the AVSS test by RigiScan Plus can objectively evaluate the efficacy of sildenafil, and shows potential for predicting that efficacy. Copyright © Taylor & Francis Group, LLC.
  • K Hiraoka, A Kawauchi, J Soh, H Ohe, H Shima, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 13 1 89 - 91 2006年01月 [有り][無し]
     研究論文(学術雑誌) 
    We report case of partial androgen insensitivity syndrome in a 12-year-old boy referred to our clinic complaining of bilateral gynecomastia and left undescended testicle. Laparoscopy for undescended testicle and bilateral mastectomy were performed, and the left testicle was absent. When skin fibroblasts of the scrotum obtained during surgery were cultured to analyse the androgen receptors, a slight thermolability was observed. Genomic examination of the androgen receptor gene could not detect any mutations.
  • Takeshi Nomoto, Yoichi Mizutani, Kazuya Mikami, Terukazu Nakamura, Hiroyuki Nakanishi, Akihiro Kawauchi, Tsuneharu Miki
    Japanese Journal of Urology 97 4 630 - 635 2006年 [有り][無し]
     研究論文(学術雑誌) 
    (Purpose): Only 20-30%of patients with cisplatin refractory or relapsed germ cell cancer will remain continuously disease free with salvage chemotherapy. Paclitaxel is a potent anticancer agent against a variety of solid cancers. The present study investigated the chemotherapy with paclitaxel in combination with nedaplatin, which is a derivative of cisplatin, and ifosphamide as salvage chemotherapy for cisplatin refractory germ cell cancer. (Material and methods): The combination chemotherapy consisted of paclitaxel 210 mg/m 2 on day 1, nedaplatin 100 mg/m2 on day 2 and ifosphamide 1.2 g/m2 on day 2-day 6 every three weeks. Fourteen patients with cisplatin refractory germ cell cancer, ranging in age from 17 to 44 years were enrolled onto the study. (Results): Fourteen patients were evaluated for response and toxicity. Patients received 1-14 cycles of the combination chemotherapy. The median duration of follow-up was 34 months (10-64 months). Response rate was 57.1 % (CR/PRm-: 8 cases, NC: 5 cases, PD: 1 cases). Seven patients remain alive without disease. However, 5 patients died of the disease. All patients had grade 3 or 4 hematological toxicity. (Conclusion): This study demonstrates that the chemotherapy with paclitaxel in combination with nedaplatin and ifosphamide showed a significant anticancer activity for patients with cisplatin refractory or relapsed germ cell cancer. These findings suggest that the combination chemotherapy may be one of the options of salvage chemotherapy for cisplatin refractory or relapsed germ cell cancer.
  • A Kawauchi, A Fujito, K Yoneda, J Soh, Y Naitoh, Y Mizutani, T Miki
    JOURNAL OF ENDOUROLOGY 19 8 984 - 986 2005年10月 [有り][無し]
     研究論文(学術雑誌) 
    A 4-year-old boy suffering from hydronephrosis of a horseshoe kidney underwent laparoscopic pyeloplasty with isthmectomy. Pyeloplasty was performed by the transposition of crossing vessels and the Anderson-Hynes method. In isthmectomy, Ligasure (R) was used for transection of the isthmus. The surgery time was 310 minutes, the estimated blood loss was 10 mL, and the patient required no analgesia postoperatively. Convalescence was complete within 14 days. The follow-up diuretic renal scan showed prompt emptying of the radioisotope from the left collecting system, with a T1/2 of 12 minutes.
  • Y Naitoh, A Kawauchi, Y Yamao, H Seki, J Soh, K Yoneda, Y Mizutani, T Miki
    UROLOGY 66 3 632 - 635 2005年09月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To evaluate the effectiveness of alarm-based combination therapy using desmopressin and imipramine for primary monosymptomatic nocturnal enuresis. Methods. Of the 105 patients, 37, were treated with alarm monotherapy (monotherapy group), 35 were treated with desmopressin combined with an alarm (desmopressin group), and 33 were treated with imipramine combined with an alarm (imipramine group). The therapeutic effects were evaluated at 3 and 6 months. The relapse rates and predictive factors of the therapies were also studied. Results. No significant differences were found in the changes in the frequency of wet nights among the three groups, although the frequencies in all three groups decreased significantly with the therapeutic duration. Although the improvement rates at 3 months did not differ among the three groups, the improvement rate of 80% in the desmopressin group and 79% in the imipramine group at 6 months were greater than the 59% rate in the monotherapy group. After cure, no patients relapsed in the monotherapy group, and 3 (43%) each did so in the desmopressin and imipramine groups. In comparing the improved cases in each group, no significant differences were found in background factors. Conclusions. Desmopressin and imipramine combined with an alarm was no more effective than alarm monotherapy. As for alarm monotherapy, other therapeutic modalities should be considered if it has not proved effective after 3 months. In such a situation, combination therapy may be effective as a second choice. No predictive factors for the therapeutic effects in the three modalities were found.
  • Akira Fujito, Akihiro Kawauchi, Kimihiko Yoneda, Osamu Ukimura, Tsuneharu Miki
    Acta Urologica Japonica 51 8 523 - 525 2005年08月 [有り][無し]
     研究論文(学術雑誌) 
    We report the efficacy of radio-frequency ablation (RFA) for T1a renal cell carcinoma (RCC). RFA was performed under epidural or local anesthesia by ultrasound or computed tomography (CT) guidance in seven patients with T1a RCC, who were at significant operative or anesthetic risk for invasive surgery. At a median follow-up of 17.5 months, 6 (86%) of the seven patients showed no tumor enhancement in follow-up CT scans or magnetic resonance images. Temporary macroscopic hematuria was observed in one case. RFA is an effective and safe minimally invasive therapeutic option for selected patients with RCC who have reason to avoid invasive surgery under general anesthesia.
  • A Ochiai, Y Naya, J Soh, Y Ishida, Y Mizutani, A Kawauchi, T Fujiwara, T Miki
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH 17 4 339 - 342 2005年07月 [有り][無し]
     研究論文(学術雑誌) 
    The aim of this study was to assess the efficacy of sildenafil as the first-step tool for erectile dysfunction (ED) in Japanese males. Between March 1999 and March 2003, 281 patients were prescribed five tablets of sildenafil (50 mg) as the first step in the therapeutic management of ED. Of the 281 patients, 206 were evaluable patients. The overall success rate in achieving sexual intercourse in subjects after taking sildenafil was 77.2% (159/206), while 22.8% (47/206) were unsuccessful. The success rates in men with functional ED and organic ED were 91.4% (85/93) and 65.5% (74/113), respectively (P<0.0001). Overall, transient adverse effects of sildenafil occurred in 16 (8%) males. Intolerable adverse effects (edema and dizziness) occurred in only 1% of patients (2/206). Sildenafil citrate may be recommended as the first choice drug for ED because of its high success rate and low invasiveness.
  • O Ukimura, A Kawauchi, M Kanazawa, H Miyashita, K Yoneda, M Kojima, T Nakanouchi, T Miki
    BJU INTERNATIONAL 96 1 98 - 102 2005年07月 [有り][無し]
     研究論文(学術雑誌) 
    OBJECTIVES To assess the effects of giving chlormadinone acetate (CMA) before surgery on blood loss associated with transurethral resection of the prostate (TURP), in a prospective randomized controlled study. PATIENTS AND METHODS Candidates for TURP among patients with benign prostatic hyperplasia were randomized to either treatment with CMA (CMA+) or not (CMA-). In principle, CMA was started at least 28 days before TURP and continued until just before surgery. RESULTS In all, 33 patients in the CMA+ (median duration of treatment 34.5 days) and 38 in the CMA- group were evaluable. The mean blood loss during TURP was less in the CMA+ (237.3 mL) than in the CMA- group (263.1 mL), but the difference was not significant. There was significantly less blood loss per gram of resected prostate tissue in the CMA+ (9.6 mL/g) than in the CMA- group (13.3 mL/g) (P < 0.05). Haematuria on the day of and the day after TURP was also significantly less severe in the CMA+ than in the CMA- group (P < 0.001 and P < 0.05, respectively). The mean microvessel density of resected prostate tissue was significantly less after CMA treatment (P < 0.001). CONCLUSIONS CMA given for 1 month before TURP could reduce blood loss to some extent during and after TURP, and this may be related to a decrease in microvessel density.
  • K Okihara, H Nakanishi, T Nakamura, Y Mizutani, A Kawauchi, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 12 7 662 - 667 2005年07月 [有り][無し]
     研究論文(学術雑誌) 
    Background: We retrospectively reviewed a large series of Japanese men with histologically proven prostate cancer to assess the clinical characteristics of the cancer in three different eras of prostate cancer management since prostate-specific antigen (PSA) testing started in 1988. Methods: The medical records of 1125 patients treated between 1975 and 2002 were reviewed with respect to age, chief complaints, clinical stage, tumor grade, treatment options at each stage, and prognosis. We classified the patients as follows: those treated in the pre-PSA era between 1975 and 1988 (n = 182), those treated in the PSA era between 1988 and 1997 (n = 301; PSA era phase 1) and the PSA era between 1998 and 2002 (n = 642; PSA era phase 2). Results: Compared with the pre-PSA era, there were significant increases in the proportion of well-differentiated adenocarcinoma with respect to the biopsy tumor grade (24 vs 35%, P < 0.01), in the proportion of clinically organ-confined disease (21 vs 43%, P < 0.001), and in the proportion of patients who underwent radical prostatectomy (13%vs 20%, P < 0.01) after PSA testing was introduced. In addition, there was a significant difference in the proportion of subjects who were 70-79 years of age between the pre-PSA era (52%, 95/182) and the PSA era phase 2 (42%, 270/642, P < 0.05). There was also a significant difference in the proportion of patients who underwent surgical castration between the pre-PSA era (78%) and PSA era phase 2 (10%, P < 0.001). The proportion of patients participating in prostate cancer screening increased from 3% (pre-PSA era) to 11% (PSA era phase 1 and PSA era phase 2, P < 0.05). In all clinical stages, there were significant differences between the pre- and post-PSA eras in cause-specific survival rates (5-year: 74 vs 94% in stages A and B, P < 0.01; 54 vs 89% in stage C, P < 0.001; 32 vs 53% in stage D, P < 0.001). Conclusions: Migrations in the age of patients (toward younger patients), the stage of the cancer (towards earlier stages) and the histological findings (toward favorable findings), in addition to changes in treatment options, have contributed to the prolonged survival of Japanese men with prostate cancer after the PSA testing was introduced.
  • Y Mizutani, H Nakanishi, K Yamamoto, YN Li, H Matsubara, K Mikami, K Okihara, A Kawauchi, B Bonavida, T Miki
    JOURNAL OF CLINICAL ONCOLOGY 23 3 448 - 454 2005年01月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pl (Smac/DIABLO) was recently identified as a protein that is released from mitochondria in response to apoptotic stimuli and promotes apoptosis by antagonizing inhibitor of apoptosis proteins. Furthermore, Smac/DIABLO plays an important regulatory role in the sensitization of cancer cells to both immune- and drug-induced apoptosis. However, little is known about the clinical significance of Smac/DIABLO in various cancers, including renal cell carcinoma (RCC). This study examined Smac/DIABLO expression in 78 healthy kidneys and 78 RCCs. Materials and Methods The level of Smac/DIABLO expression was quantified by Western blot analysis using nonfixed fresh frozen tissues. Results The expression of Smac/DIABLO was lower in RCC compared with the autologous normal kidney. Sixty-four (82%) of 78 of RCC expressed Smac/DIABLO, and 18% were negative, whereas 100% of normal kidney tissues were positive. In stage I/II RCC, 96% expressed Smac/DIABLO, whereas only 50% expressed Smac/DIABLO in stage III/IV. Smac/DIABLO expression inversely correlated with the grade of RCC. Patients with RCC expressing Smac/DIABLO had a longer postoperative disease-specific survival than those without Smac/DIABLO expression in the 5-year follow-up. Transfection with Smac/DIABLO cDNA enhanced tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -mediated and cisplatin-mediated cytotoxicity in RCC Conclusion The present study demonstrates for the first time that Smac/DIABLO expression was downregulated in RCC and that no Smac/DIABLO expression in RCC predicted a worse prognosis. In addition, transfection with Smac/DIABLO sensitized RCC to TRAIL/cisplatin-induced apoptosis. These results suggest that Smac/DIABLO expression in RCC may be used as a prognostic parameter, and that enhancement of Smac/DIABLO expression in RCC may potentiate immunotherapy and chemotherapy. (C) 2005 by American Society of Clinical Oncology.
  • A Kawauchi, A Fujito, J Soh, K Yoneda, O Ukimura, Y Mizutani, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 12 1 1 - 6 2005年01月 [有り][無し]
     研究論文(学術雑誌) 
    Aim: To evaluate the learning curve of hand-assisted retroperitoneoscopic nephrectomy (HALS) performed by less-experienced surgeons. Methods: The operative records of 166 patients, including 103 with renal tumors and 63 with renal pelvic or ureteral tumors, who underwent HALS performed by 18 less-experienced urologists were reviewed. Results: The insufflation time in the first four cases was significantly longer than that in the sixteenth and later cases. The insufflation time in cases 5-10 was 14-24 min longer than that in the cases 16 onward, although the differences were not significant. The estimated blood loss did not differ in each group of cases. The complication rate in early cases, in which the operators' experience was five cases or less, was 6% (4/71), while that in later cases was also 7% (7/95). In the analysis of the learning curve of a single surgeon who performed 57 procedures, the insufflation time in cases 1-5 was significantly longer than in cases 41-57. The insufflation times in cases 5-10 were 45 min longer than those in cases 41-57, although the difference was not significant. The estimated blood loss did not differ in each group of cases. Complications did not seem related to operation experience. Conclusion: In HALS, 5-10 cases were necessary for less-experienced urologists to gain average operating skills for this procedure. It may be reasonable for less-experienced surgeons to begin standard laparoscopic procedures after experiencing 10 cases of the present procedure.
  • O Ukimura, A Kawauchi, A Fujito, Y Mizutani, K Okihara, K Mikami, J Soh, T Nakamura, H Nakanishi, S Ushijima, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 11 12 1051 - 1057 2004年12月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: Although radio-frequency ablation (RFA) has been recently applied as a minimally invasive treatment option for renal cell carcinoma (RCC), indication of this modality remains a critical issue due to the lack of complete tumor destruction as well as the uncertainty of its long-term efficacy. We report the efficacy of RFA for nine carefully selected patients with RCC who had significant reason to avoid invasive surgical treatment under general anesthesia. Methods: Radio-frequency ablation was performed under epidural or local anesthesia by ultrasound or computed tomography (CT) guidance in nine patients with biopsy proven RCC (mean diameter, 38 mm; range, 20-53 mm), who were at significant operative or anesthetic risk for invasive surgery. Follow-up enhanced CT scans or magnetic resonance images were evaluated every 3-6 months and an evaluation of metastasis was performed every 6 months. Results: At a mean follow-up of 17 months, seven (78%) of the nine patients with renal tumor showed no tumor enhancement. The renal function of all patients was well preserved. All patients were able to continue undergoing their respective treatments for active diseases in other organs in parallel to the RFA treatment. No distant metastasis, urine leakage were reported and one case of temporary hematuria and one case of peri-renal hemorrhage not requiring blood transfusion were encountered. Intra-operative ultrasonography was useful in the real-time monitoring of the minimally excessive extension of ablation into the normal parenchyma. Conclusion: Radio-frequency ablation appears to be an effective and safe minimally invasive therapeutic option for selected patients with RCC who have reason to avoid invasive surgery under general anesthesia.
  • Y Mizutani, H Nakanishi, YN Li, N Sato, A Kawauchi, T Miki
    JOURNAL OF UROLOGY 172 4 1474 - 1479 2004年10月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: Cyclooxygenase-2 (COX-2) is a key inducible enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in various cancer cells. Several anticancer agents also mediate apoptosis and may share the common intracellular pathways leading to apoptosis with COX-2 inhibitors. We reasoned that combination treatment of bladder cancer cells with COX-2 inhibitors and anticancer agents may result in synergistic apoptosis. We examined whether the selective COX-2 inhibitor JTE-522 (4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide) synergizes with anticancer agents in cytotoxicity and apoptosis against bladder cancer cells in vitro and in vivo. Materials and Methods: Cytotoxicity was determined by the microculture tetrazolium. dye assay. Results: Combination treatment of T24 bladder cancer cells with JTE-522 and cisdiamminedichloroplatinum. (II) (CDDP) resulted in a synergistic cytotoxic effect. Synergy achieved in cytotoxicity with JTE-522 and CDDP was shown to be due to apoptosis. Treatment of T24 cells with JTE-522 decreased expression of the anti-apoptotic molecule Bcl-2. The in vivo significant growth inhibitory effect of JTE-522 and CDDP against the T24 line heterotransplanted in SCID mice was also observed. Conclusions: This study demonstrates that combination treatment of bladder cancer cells with the selective COX-2 inhibitor JTE-522 and CDDP results in synergistic cytotoxicity and apoptosis in vitro and in vivo. These findings support the potential clinical application of a combination of JTE-522 and CDDP for the treatment of bladder cancer as a new form of therapy with more selective cytotoxicity and fewer collateral side effects.
  • Y Mizutani, H Matsubara, K Yamamoto, YN Li, K Mikami, K Okihara, A Kawauchi, B Bonavida, T Miki
    CANCER 101 8 1794 - 1802 2004年10月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediated apoptosis. Thus, OPG may protect tumor cells from lymphocyte-mediated cytotoxicity and, as a result, contribute to tumor progression. In the current study, the authors investigated this hypothesis in patients with bladder carcinoma. METHODS. Serum OPG levels for 185 patients with bladder carcinoma were determined using an enzyme-linked immunosorbent assay. These levels then were assessed for potential correlations with various disease characteristics and outcome measures. RESULTS. The mean serum OPG concentration in patients with bladder carcinoma was approximately 3 times greater than the mean concentration in healthy individuals, and among patients with bladder carcinoma, higher tumor stage and grade were found to be associated with increased serum OPG levels. Within the subpopulation of patients with superficial bladder carcinoma, after a follow-up period of 5 years, those who had low serum OPG levels tended to have a longer postoperative tumor-free interval compared with those who had high serum OPG levels. Furthermore, among patients with muscle-invasive bladder carcinoma, the 5-year disease-specific survival rate was greater for those who had low serum OPG levels than for those who had high serum OPG levels. CONCLUSIONS. To the authors' knowledge, the current study is the first to demonstrate that serum OPG concentration is correlated with both tumor stage and tumor grade and that elevated serum OPG levels are predictive of early recurrence in patients with bladder carcinoma. These findings suggest that serum OPG concentration may have utility as a prognostic parameter in this setting.
  • K Okihara, O Ukimura, T Nakamura, Y Mizutani, A Kawauchi, Y Naya, M Uchida, T Ogiwara, T Miki
    EUROPEAN UROLOGY 46 1 57 - 64 2004年07月 [有り][無し]
     研究論文(学術雑誌) 
    Backgrounds: The aim of this study is to ascertain whether Bayer complexed PSA (cPSA) and volume referenced cPSA could enhance the detection of prostate cancer in Japanese men. Methods: A total of 214 Japanese men whose serum total PSA (tPSA) values ranged from 1.2 ng/ml to 4600 ng/ml were enrolled from two institutions. Serum samples for tPSA, free PSA, PSA-alpha-1-antichymotripsin (PSA-ACT) and cPSA (ADVIA-Centaur) were obtained in all cases. In addition, total gland (TGV) as well as transition zone volume (TZV) were determined in all cases who underwent untrasound guided prostate biopsy (sextant and two additional transition zone biopsies). Biopsy outcome was correlated to the following parameters: tPSA, cPSA, PSA-ACT, free to total (F/T) PSA ratio, 2 complex to total (C/T) PSA ratios and 6 volume referenced parameters. Results: Prostate cancer was detected in 85 of 214 patients (40%). The area under the receiver operating characteristic curve in non-volume referenced variables was highest for cPSA (0.736), followed by PSA-ACT (0.735), tPSA (0.722), F/T PSA ratio (0.613) and C/T PSA ratio (0.591). Comparing tPSA with the cutoff value of 4.0 ng/ml, the cutoff value with a 2.8 ng/ml of cPSA detected one more positive biopsy patient, decreasing one more cancer missed case and 8 more false positive cases. At sensitivities of 85% to 95% in men with tPSA between 4.00 and 10.00 ng/ml (n = 116), there were no significant differences in the corresponding specificities between tPSA and cPSA, or between cPSA and PSA-ACT At sensitivities of 90% to 95%, the corresponding specificities of PSA-ACT adjusted for transition zone volume revealed best performance. As for the performance in men with a tPSA less than 4.0 ng/ml, the specificities of cPSA performed best, and differed significantly from PSA-ACT and F/T PSA at sensitivities of 80% to 90%. Conclusion: Bayer cPSA could replace the first screening test by total PSA and can enhance cancer detection, compared with PSA-ACT. However, cPSA did not provide additional value in differentiating cancer from non-cancer cases in men with a tPSA between 4.00 and 10.00 ng/ml. (C) 2003 Elsevier B.V. All rights reserved.
  • O Ukimura, IS Gill, MM Desai, AP Steinberg, M Kilciler, CS Ng, SC Abreu, M Spaliviero, AP Ramani, JH Kaouk, A Kawauchi, T Miki
    JOURNAL OF UROLOGY 172 1 112 - 118 2004年07月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: We describe the technical aspects of real-time transrectal ultrasound (TRUS) monitoring and guidance during laparoscopic radical prostatectomy (LRP). Furthermore, we describe the TRUS visualized anatomy of periprostatic structures during LRP. Materials and Methods: In 25 consecutive patients undergoing transperitoneal LRP, baseline preoperative, real-time intraoperative and immediate postoperative TRUS evaluations were performed. To define periprostatic anatomy precisely TRUS measurements were obtained with specific reference to the neurovascular bundle (NVB), prostate apex, membranous urethra, bladder neck, rectal wall and any cancer nodule. Conventional gray scale, power Doppler, harmonic imaging and 3-dimensional ultrasound functions were used. Results: Real-time TRUS navigation facilitated 3 technical aspects of LRP. 1) It identified the correct plane between the posterior bladder neck and prostate base, allowing quick laparoscopic identification of the vasa and seminal vesicles. 2) It identified the occasional, difficult to see distal protrusion of the prostate apex posterior to the membranous urethra, thus enhancing apical dissection with negative margins. 3) It provided visualization of any hypoechoic nodule abutting the prostate capsule, alerting the laparoscopic surgeon to perform wide dissection at that location. TRUS measured various anatomical parameters including i) the mean distance +/-SD between the NVB and the lateral edge of the prostate a) at apex (1.9 +/- 0.9 mm), b) base (2.5 +/- 0.8 mm) and c) tip of seminal vesicle (4.0 +/- 1.6 mm), ii) the dimensions of the NVB a) before (4.5 X 3.9 mm), b) after (4.2 X 3.6 mm) nerve sparing LRP and c) after nonnerve sparing LRP (0.9 x 0.9 mm), iii) arterial blood flow resistive index within NVB a) before (0.83 +/- 0.04), b) after (0.84 +/- 0.03) nerve sparing LRP and c) after nonnerve sparing LRP (0), iv) and the length of membranous urethra a) before (12.2 +/- 1.1 mm) and b) after (11.7 +/- 1.0 mm) surgery. Focal distortion of the prostate surface by an exophytic nodule was visualized on TRUS in 3 patients, necessitating ipsilateral nerve resection at LRP and contributing to negative surgical margins. Conclusions: This initial experience suggests that real-time intraoperative TRUS guidance may enhance anatomical performance of LRP. This improved understanding of periprostatic anatomy has the potential to improve functional and oncological outcomes. Such corroboration is awaited.
  • H Iwasaki, Y Koyama, Y Tanaka, A Kawauchi, E Jodo, Y Kayama, T Miki
    UROLOGY 63 5 994 - 998 2004年05月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To examine the effect of desmopressin (DDAVP) on bladder contraction and on the neurons that fire in relation to spontaneous bladder contraction (bladder-related neurons) in and around Barrington's nucleus, the micturition center. DDAVP is used for the treatment of nocturnal enuresis because of its antidiuretic action, but the mechanism of this action has not been proved. Methods. Urethane-anesthetized Sprague-Dawley male rats (n = 20) were used. DDAVP was infused intravenously or as an intracerebroventricular infusion into the lateral ventricle. Results. We encountered three types of bladder-related neurons: those that fired before the start of the contraction (type E I), those that fired synchronous with the bladder contraction (type E2), and those that fired during bladder relaxation (type 1). Intravenous infusion caused inhibition in three of five type El neurons, excitation in two of five type E2 neurons, and excitation (one neuron) and inhibition (one neuron) of four type I neurons. With intracerebroventricular infusion into the lateral ventricle, two of four type El neurons were inhibited, and one of seven type E2 neurons and three of four type I neurons were excited. Bladder contraction was suppressed in 4 of 12 rats by intravenous infusion and in 2 of 8 rats by intracerebroventricular infusion into the lateral ventricle. In all cases, when the bladder contraction was suppressed, an electroencephalogram of larger amplitude and slower frequency appeared. Conclusions. DDAVP seems to regulate bladder activity by affecting bladder-related neurons in the micturition center. (C) 2004 Elsevier Inc.
  • O Ukimura, T Iwata, S Ushijima, K Suzuki, H Honjo, K Okihara, Y Mizutani, A Kawauchi, T Miki
    ULTRASOUND IN MEDICINE AND BIOLOGY 30 5 575 - 581 2004年05月 [有り][無し]
     研究論文(学術雑誌) 
    Recently, we reported that the anterior fibromuscular stroma (AFMS) of the prostate has significant different innervation compared with the other glandular regions of the prostate. In healthy volunteers (n = 12) using transrectal ultrasound (US), or TRUS, monitoring during voiding, we observed dynamic change (p < 0.0001) of the thickness of the AFMS during voiding. The aim of this study was to reveal the possible functional contribution of the AFMS to micturition, as well as the age-related voiding dysfunction. In the patients (n = 56) with voiding dysfunction who underwent both pressure-flow study (PFS) for determining obstruction and TRUS monitoring during voiding, we measured the ultrasonic dynamic change of the lower urinary tract during voiding. In old men with voiding dysfunction, ultrasonic measurements of dynamic change in the AFMS (p < 0.01) as well as the opening urethra (p < 0.05) could contribute to diagnosing of the anatomical localization of obstructive lesions. The poor movement of AFMS could account for the age-related urinary disturbance in the patients without benign prostatic enlargement and without bladder neck obstruction. (E-mail: ukimura@koto.kpu-m.ac.jp) (C) 2004 World Federation for Ultrasound in Medicine Biology.
  • A Kawauchi, A Fujito, J Soh, O Ukimura, Y Mizutani, T Miki
    JOURNAL OF ENDOUROLOGY 18 4 365 - 369 2004年05月 [有り][無し]
     研究論文(学術雑誌) 
    In laparoscopic operations for renal tumor and upper urinary-tract transitional-cell carcinoma (TCC), three approaches-the transperitoneal, retroperitoneal, and transperitoneal hand-assisted-have been reported. We have performed hand-assisted retroperitoneoscopic radical nephrectomy (RN) since 1999 and nephroureterectomy (NU) since 2000. The surgical techniques and the operative results of 95 cases of RN and 54 cases of NU are described and analyzed. These procedures were effective and safe for renal tumors and upper urinary-tract TCC.
  • O Ukimura, S Ushijima, H Honjo, T Iwata, K Suzuki, N Hirahara, K Okihara, Y Mizutani, A Kawauchi, T Miki
    EUROPEAN UROLOGY 45 1 70 - 76 2004年01月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: To evaluate human bladder. mucosal sensory function by neuroselective Current Perception Threshold (CPT) measures from healthy and neuropathic bladders. Methods: Eight healthy volunteers and 38 patients with urinary symptoms underwent conventional urodynamic tests including water-filling cystometry and ice water test. Standardized neuroselective CPT measures were obtained from the left index finger and the mucosa of the posterior bladder wall. Three different CPTs were obtained from each test site using a constant alternating current sinusoid waveform electrical stimulus presented at 2000 Hz, 250 Hz and 5 Hz stimulation frequencies, which could selectively reflect the functions of the large myelinated fibers (A-beta-fiber), the small myelinated fibers (A-delta-fiber), and the unmyelinated fibers (C-fiber), respectively. Results: As the determination of CPT values on the finger skin, the CPT values in the bladder could be determined using the neuroselective measures in all patients but three who had no sensory response (absence of sensation) caused by complete spinal injury. In the 8 patients with detrusor hyperreflexia due to incomplete spinal cord injury (supra-sacral lesion), the bladder CPT value (4.0 +/- 1.9) at 5 Hz was significantly lower (p < 0.01) than that in the controls (26.2 +/- 17.7). In the neurogenic bladders determined to be underactive (n = 11, including post pelvic surgery, post infra-sacral level spinal cord injury and diabetes patients), the higher CPT values of bladder mucosal sensory functions were found at 5 Hz (p < 0.05), 250 Hz (p = 0.07), and 2000 Hz (p < 0.05) compared to the controls. Conclusions: Quantitative neuroselective measurement of CPT values in the human bladder mucosal function was feasible. Hypersensitivity or hyposensitivity of the urinary sensory function could be determined using the CPT values in comparison to control. The quantitative neuroselective estimation of the bladder sensory functions in different types of sensory peripheral nerve fibers may contribute to the appropriate selection of therapeutic strategy in patients with urinary sensory dysfunction. (C) 2003 Elsevier B.V. All rights reserved.
  • A Kawauchi, A Fujito, Y Naito, J Soh, O Ukimura, K Yoneda, Y Mizutani, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 11 1 7 - 10 2004年01月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To evaluate the feasibility of retroperitoneoscopic heminephroureterectomy for children with duplex anomaly. Methods: Retroperitoneoscopic heminephroureterectomy was performed in five children (four girls and one boy) with complete duplication of the ureter, of whom four (age range 1-5 years; mean age 3.3 years) had upper pole ectopic megaureters and one (3 years old) had an upper pole megaureter with ureterocele. In the patient with ureterocele, distal ureterectomy and ureterocelectomy were performed by Pfannenstiel incision. Results: The mean operation time was 346 min (range 270-450 min) in the four patients with ectopic megaureter and 420 min (330 min for heminephroureterectomy) in the patient with ureterocele. The mean estimated blood loss was 43 mL (range 5-100 mL) in the four patients with ectopic megaureter and 40 mL in the patient with ureterocele. No postoperative complications were observed. Postoperative intravenous pyelography showed normal pyelogram and renal function of the preserved lower pole in all cases. Conclusions: Retroperitoneoscopic heminephroureterectomy for children is feasible, safe and has good postoperative results, including cosmetic results. However, the operation time needs to be reduced.
  • H. Nakanishi, O. Mazda, E. Satoh, H. Asada, H. Morioka, T. Kishida, M. Nakao, Y. Mizutani, A. Kawauchi, M. Kita, J. Imanishi, T. Miki
    Gene Therapy 10 21 1860  2003年10月 [有り][無し]
     研究論文(学術雑誌)
  • Y Naitoh, A Kawauchi, Y Mizutani, O Ukimura, A Fujito, M Nakao, Y Kojima, N Nonomura, A Okuyama, T Miki
    EUROPEAN UROLOGY 44 4 452 - 457 2003年10月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: The effects of intratumoral ethanol injection on renal cell carcinoma (RCC) heterotransplanted in nude rats were evaluated. Materials and Methods: The OUR95AF human RCC cell line was inoculated subcutaneously into the backs of nude rats. Four weeks after transplantation, the size of tumors became 1.5-2.0 cm in maximal length, and 95% ethanol was injected intratumorally once a week for five weeks. The effectiveness of this treatment was evaluated by measurement of tumor volume, magnetic resonance (MR) imaging using Gadopentetate-diethylenetriaminepentaacetic acid (Gd-DTPA) and histological examinations. Results: In the ethanol injected group, no increase in tumor volume was recognized. The growth of the tumors was significantly suppressed after the third injection. Non-enhanced parts in MR imaging were observed in the central region of the tumors at the second injection, and increased at the third injection. After the fifth injection, only small parts of non-enhanced regions remained. Degenerative necrosis was histologically found in the non-enhanced parts of the MR image. The signal to noise ratio (SNR) and the contrast to noise ratio (CNR) calculated from T1 weighted imaging using Gd-DTPA, and relative enhancement (RE) were thought to be good parameters for evaluating the effect of ethanol injections. Conclusion: Intratumoral ethanol injection was very effective against RCC. Five weekly injections of ethanol induced necrosis of the tumor. MR imaging using Gd-DTPA may be a useful method for evaluating the effect of ethanol injection. (C) 2003 Elsevier B.V. All rights reserved.
  • Y Naya, Y Mizutani, A Ochiai, J Soh, A Kawauchi, A Fujito, N Nakamura, T Ono, N Iwamoto, T Aoki, K Marumo, M Murai, T Miki
    UROLOGY 62 3 532 - 536 2003年09月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To investigate the effect of chronic diseases on erectile dysfunction (ED) in Japanese middle-aged men using the International Index of Erectile Function, 5-item version (IIEF-5). Methods. The subjects consisted of 640 healthy men and 396 men with chronic disease who responded to the IIEF-5 questionnaire (mean age 43.6 +/- 8.3 years, range 30 to 59). The incidence and severity of ED were calculated in three age groups (30 to 39, 40 to 49, and 50 to 59 years). Results. The incidence of hypertension, cardiac disease, diabetes mellitus, and chronic renal failure was associated with the incidence and severity of ED, as was age. In stepwise multivariate logistic regression analysis, cardiac disease was the strongest independent risk factor (odds ratio [OR] 6.5), followed by diabetes mellitus (OR 5.9), chronic renal failure (OR 3.9), hypertension (OR 2.0), and age (OR 1.8). Conclusions. The results of this study demonstrated that the risk of ED increases with the presence of cardiac disease, diabetes mellitus, chronic renal failure, and hypertension in middle-aged men in Japan.
  • Nagashima T, Kawauchi A, Miki T, Oune T, Ito H
    Hinyokika kiyo. Acta urologica Japonica 49 9 527 - 529 2003年09月 [有り][無し]
  • Y Mizutani, H Wada, O Yoshida, M Fukushima, A Kawauchi, M Nakao, T Miki
    CANCER 98 4 730 - 736 2003年08月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND. Thymidine phosphorylase (TP) is identical to platelet-derived endothelial cell growth factor (PDECGF) and has angiogenic activity. Little is known about the significance of TP/PDECGF activity in patients with renal cell carcinoma (RCC). The authors examined the enzymatic activity of TP in 66 RCC specimens and investigated the association between the level of TP activity and the stage/grade status of patients with RCC. Furthermore, the authors examined the correlation between TP/PDECGF activity and prognosis. METHODS. TP activity levels in nonfixed, fresh-frozen RCC specimens and in specimens of normal kidney were determined using a thin-layer chromatography assay. RESULTS. The activity of TP was approximately 3.5-fold greater in RCC specimens compared with normal kidney specimens. TP activity in patients with Stage III-IV RCC was 2.6-fold greater compared with TP activity in patients with Stage I-II RCC. In addition, the level of TP activity was correlated with a higher grade of RCC. Patients who had RCC with low TP activity had a longer postoperative disease-specific survival compared with patients who had RCC with high TP activity in the 5-year follow-up. CONCLUSIONS. The current study is the first to demonstrate a correlation between levels of TP activity and both disease progression and a higher grade of RCC. It also is the first to show that elevated TP activity in patients with RCC predicts a poor prognosis. The results suggest that high TP/PDECGF activity may be associated with the malignant potential of RCC and that TP/PDECGF may be a molecular therapeutic target inpatients with RCC.
  • S Senjyu, H Nishida, M Sakamoto, A Ishikawa, M Ishii, K Yoneyama, A Kawauchi, K Mitamura
    HEPATOLOGY RESEARCH 26 3 174 - 180 2003年07月 [有り][無し]
     研究論文(学術雑誌) 
    Background: Endoscopic injection sclerotherapy (EIS) for treatment of esophagogastric varices is well established in Japan. However, varices may still recur unpredictably following EIS. We studied this problem using endoscopic color Doppler ultrasonography (ECDUS) and specifically examined esophagogastric blood flows. Methods: Prophylactic EIS was performed by intravariceal injection of 5% ethanolamine oleate (EO) in 49 patients with esophageal varices secondary to liver cirrhosis. No patient had documented hepatocellular carcinoma (HCC) before EIS, and patients who developed HCC during follow-up were excluded. We performed ECDUS before EIS, and 2 weeks and 2 years later. The esophagogastric intra- and extramural venous blood flows, including flow in the azygos vein, were compared between these observations. Gastric intramural blood flow and changes in extramural gastric blood flow, including the azygos vein flow, were scored. Dynamic computer tomography (CT), ultrasonography (US), and color Doppler-ultrasonography (CDUS) were also performed before EIS and 1 month following the procedure. Thereafter, patients underwent CT and US examinations every 6 months for 2 years to detect any development of portosystemic shunts or HCC. Results: The average number of EIS procedure per patient was 3.1+/-0.8 (mean+/-SD), and the total amount of sclerosant injected was approximately 33.5+/-6.5 ml. The overall recurrence rate over the 2-year follow-up was 36.7%. The gastric intra- and extramural blood flows did not differ between those patients with or without major shunts before EIS. In patients with recurrent variceal formation, the gastric intramural blood flow score following EIS (2.1+/-0.5) was significantly higher than that in patients without recurrence (0.8+/-0.6) (P<0.01). In addition, gastric extramural blood flow score following EIS (0.8+/-0.6) was significantly lower in patients with recurrence than that in those without recurrence (1.7+/-0.5) (P<0.01). The same differences held after exclusion of patients with major shunts. The gastric intramural blood flow score in patients with recurrent variceal formation (2.1+/-0.4) was significantly higher than that in patients without recurrence score (P<0.01). Moreover, gastric extramural blood flow score in patients with recurrent variceal formation (1.0+/-0.7) was significantly lower than in patients without recurrence (1.6+/-0.5) (P<0.01). Conclusions: Two characteristics were observed in patients with recurrent cases of esophageal varices 2 weeks following EIS. The first was the maintenance of gastric intramural blood flow. The second was the absence of dilation of the gastric extramural blood vessels. These observations may enable us to predict the recurrence of esophagogastric varices using ECDUS within 2 weeks following EIS. (C) 2003 Elsevier Science B.V. All rights reserved.
  • K Okihara, O Ukimura, Y Mizutani, A Kawauchi, M Nakao, T Miki
    DRUGS OF TODAY 39 6 389 - 398 2003年06月 [有り][無し]
     研究論文(学術雑誌) 
    Various preliminary and reassessment articles focusing on power Doppler imaging to detect prostate cancer have studied the potential of this powerful tool. By identifying abnormal vascular flow, power Doppler imaging can enhance prostate cancer detection. However, according to recent articles, the applications for biopsy-guided power Doppler imaging targeting the intermediate serum prostate-specific antigen range has some limitations. Three-dimensional reconstruction of power Doppler imaging is a promising technique to improve cancer detection. (C) 2003 Prous Science. All rights reserved.
  • Koji Okihara, Osamu Ukimura, Yoichi Mizutani, Akihiro Kawauchi, Masahiro Nakao, Tsuneharu Miki
    Drugs of Today 39 6 389 - 398 2003年06月 [有り][無し]
     
    Various preliminary and reassessment articles focusing on power Doppler imaging to detect prostate cancer have studied the potential of this powerful tool. By identifying abnormal vascular flow, power Doppler imaging can enhance prostate cancer detection. However, according to recent articles, the applications for biopsy-guided power Doppler imaging targeting the intermediate serum prostate-specific antigen range has some limitations. Three-dimensional reconstruction of power Doppler imaging is a promising technique to improve cancer detection. © 2003 Prous Science. All rights reserved.
  • M Kanazawa, Y Satomi, Y Mizutani, O Ukimura, A Kawauchi, T Sakai, M Baba, T Okuyama, H Nishino, T Miki
    EUROPEAN UROLOGY 43 5 580 - 586 2003年05月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: Isoliquiritigenin, one of the components in the root of Glycyrrhiza glabra L., is a member of the flavonoids, which are known to have an anti-tumor activity in vitro and in vivo. In this study, we investigated the antitumor effect of isoliquiritigenin on prostate cancer in vitro. Methods: DU145 and LNCaP prostate cancer cell lines were used as targets. We examined the effects of isoliquiritigenin on cell proliferation, cell cycle regulation and cell cycle-regulating gene expression. Further, we investigated the effects of isoliquiritigenin on the GADD153 mRNA and protein expression, and promoter activity. Results: Isoliquiritigenin significantly inhibited the proliferation of prostate cancer cell lines in a dose-dependent and time-dependent manner. Fluorescence-activated cell sorting (FAGS) analysis indicated that isoliquiritigenin induced S and G2/M phase arrest. Isoliquiritigenin enhanced the expression of GADD153 mRNA and protein associated with cell cycle arrest. Further, isoliquiritigenin stimulated transcriptional activity of GADD153 promoter dose-dependently. Conclusion: These findings suggest that isoliquiritigenin is a candidate agent for the treatment of prostate cancer and GADD153 may play an important role in isoliquiritigenin-induced cell cycle arrest and cell growth inhibition. (C) 2003 Elsevier Science B.V. All rights reserved.
  • A Kawauchi, Y Tanaka, Y Naito, Y Yamao, O Ukimura, K Yoneda, Y Mizutani, T Miki
    UROLOGY 61 5 1016 - 1018 2003年05月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To evaluate bladder capacity at the time of enuresis and compare the daytime capacity of enuretics with that of controls. Methods. The functional bladder capacity (FBC), which was the maximal endurable capacity in the daytime, the ordinary bladder capacity (OBC), which was the capacity at ordinary urinary sensation in the daytime, and the enuretic bladder capacity (EBC), which was the capacity at the time of enuresis, were measured in 67 patients with monosymptomatic nocturnal enuresis. The EBC was measured using a diaper and enuresis alarm. The FBC, OBC, and nocturnal bladder capacity, which was the maximal voided volume in the nighttime, were also measured in 67 controls. Results. The FBC was not significantly different between enuretics and controls. The EBC in enuretics was significantly smaller than the nocturnal bladder capacity in controls. In enuretics, the EBC was significantly smaller than the FBC and was similar to the OBC. In controls, no statistically significant differences were found between the FBC and the nocturnal bladder capacity. Conclusions. In enuretics, the bladder capacity during sleep was significantly smaller than the daytime functional capacity. In controls, on the other hand, the bladder Capacity during sleep did not differ from the daytime functional capacity. Our understanding of the bladder capacity in enuretics may need to change in view of this result. The inability to hold urine during sleep may be an important cause of nocturnal enuresis. (C) 2003, Elsevier Inc.
  • A Kawauchi, A Fujito, O Ukimura, K Yoneda, Y Mizutani, T Miki
    JOURNAL OF UROLOGY 169 3 890 - 894 2003年03月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: We report our initial experience with hand assisted retroperitoneoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma and compared our results to those of a contemporary series of open nephroureterectomy. Materials and Methods: Clinical data on 34 consecutive patients who underwent hand assisted retroperitoneoscopic nephroureterectomy were reviewed and compared with those on 34 who underwent open nephroureterectomy. All specimens were extracted intact. Results: Total operative time was similar in the 2 groups (233 versus 236 minutes). Estimated blood loss was significantly less in the hand assisted laparoscopy group (236 versus 427 ml.). During convalescence the frequency of parenteral analgesia postoperatively was significantly lower in the laparoscopy group than in the open surgery group. The former patients had a significantly shorter interval to oral intake and ambulation as well as a shorter hospital stay and convalescence compared with those who underwent open surgery. In each group the complication rate was 12% (4 of 34 cases). In the hand assisted laparoscopy group 1 conversion to an open procedure was due to bleeding. There was recurrence in 4 of the 34 patients (12%) in the laparoscopy group, including 2 with bladder recurrence and 2 with metastases, at an average followup of 13.1 months. Conclusions: Hand assisted retroperitoneoscopic nephroureterectomy is an effective and safe alternative to open nephroureterectomy for upper urinary tract transitional cell carcinoma.
  • Y Tanaka, Y Koyama, Y Kayama, A Kawauchi, O Ukimura, T Miki
    BRAIN RESEARCH 965 1-2 146 - 154 2003年03月 [有り][無し]
     研究論文(学術雑誌) 
    Micturition is controlled by a network of brainstem neurons involving the Barrington's nucleus. To depict clearly the brainstem system for micturition control, the present study was designed to record single neuronal activity in the mesopontine tegmentum including the Barrington's nucleus, and to observe its precise timing in relation to bladder contraction recorded simultaneously. About 1/5 of neurons encountered had firing modulated in relation to bladder contraction. Three types of neurons were distinguished; those which fired only prior to the start of contraction (type E1), those whose firing started shortly prior to and was maintained during contraction (type E2), and those whose firing was strongly suppressed during contraction (type I). Type E2 neurons were most frequently observed in the Barrington's nucleus and its close vicinity, while the neurons of the other two types were scattered widely in the mesopontine tegmentum. The results show clearly that direct neural signals to induce bladder contraction may arise from the Barrington's nucleus. and that the nucleus may receive regulatory inputs from wide areas of the mesopontine tegmentum. In addition, the present study clarified that the noradrenergic and cholinergic neurons, which are located in nuclei adjoining the Barrington's nucleus and function to control sleep/ wakefulness, may not be concerned in controlling micturition directly. (C) 2002 Elsevier Science B.V. All rights reserved.
  • H Nakanishi, Y Mizutani, A Kawauchi, O Ukimura, T Shiraishi, M Hatano, M Mizuno, J Yoshida, T Miki
    CLINICAL CANCER RESEARCH 9 3 1129 - 1135 2003年03月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: Immunotherapy is the most effective treatment against metastatic renal cell carcinoma (RCC). However, the response rate is similar to15%. More effective therapy is, therefore, needed for patients with metastatic RCC. We then examined the antitumor effect of cationic multilamellar liposome containing human IFN-beta (huIFN-beta) gene (IAB-1) against RCC. Experimental Design: Concentrations of huIFN-beta protein were measured by ELISA. The cytotoxicity of IAB-1 against human RCC (NC65, ACHN, and freshly isolated RCC cells), prostate and bladder cancer cell lines, and renal proximal tubule endothelial cells (RPTEC5899) was examined by the colorimetric method using tetrazolium salt. Apoptosis was assessed by the acridine-orange staining. For in vivo study, we used NC65 cells inoculated into severe combined immunodeficiency mouse. Results: The RCC cells treated with IAB-1 secreted significant amounts of huIFN-beta protein continuously. Drastic in vitro cytotoxic effect of IAB-1 against RCC was observed. In contrast, treatment with 1000 IU/ml recombinant huIFN-beta protein resulted in weak cytotoxicity. The cytotoxic effect against prostate and bladder cancer cell lines was less than that against RCC. Furthermore, no significant cytotoxicity was observed in RPTEC5899 cells. Apoptosis was observed in the cells treated with IAB-1, but recombinant huIFN-beta failed to induce apoptosis. The size of NC65 tumors transfected with IAB-1 in mice was significantly smaller than that receiving injection of empty liposome or recombinant huIFN-beta protein. Conclusion: These findings indicate that IAB-1 may have an antitumor activity against human RCC by inducing apoptosis, suggesting its potential clinical application for gene therapy against RCC.
  • A Kawauchi, A Fujito, J Soh, O Ukimura, Y Mizutani, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 10 2 90 - 93 2003年02月 [有り][無し]
     研究論文(学術雑誌) 
    We report two female cases with vesicoureteral reflux (VUR) who underwent laparoscopic correction of VUR by the Lich-Gregoir technique. One patient was 10 years of age, with international grade III reflux of the left ureter; the other was 27 years of age, with grade II reflux of the right ureter. The respective operating times were 6 h 40 min and 6 h 10 min. There were no complications during surgery. Although post-surgical ultrasonography revealed mild hydronephrosis in the adult patient, the condition resolved spontaneously 2 months after surgery. The disappearance of reflux was confirmed in both cases by voiding cystography 6 months after surgery.
  • Y Tanaka, A Kawauchi, K Yoneda, Y Naitoh, Y Yamao, H Iwasaki, Y Mizutani, T Miki
    EUROPEAN UROLOGY 43 1 80 - 83 2003年01月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To clarify the characteristics of vesicoureteral reflux detected in patients with nocturnal enuresis. Methods: Voiding cystourethrography (VCUG) was applied in 1088 patients who visited our outpatient clinic with the chief complaint of nocturnal enuresis. The clinical features of reflux were evaluated and the prognosis of reflux and nocturnal enuresis was analyzed. Results: Reflux was detected in 86 ureters in 70 patients (6.4%) out of the 1088 patients. The grade of reflux was 3 or less in all cases. The incidence of pyuria was 5 (7%) and that of renal scar during first examination was 1 (1%). The incidence of unstable bladder was 30 (75%) in 40 patients. The resolution rate of reflux in the cases which were followed-up for 2 years or more by conservative treatment was 50-66% for each grade of reflux. The percentage of patients who had siblings with a positive history of nocturnal enuresis and the incidence of frequency differed significantly between the enuretics with reflux and the 507 enuretics without urological abnormalities. Conclusions: Our data suggest that the incidence of reflux in patients with nocturnal enuresis was rather low in comparison with the past literature, the severity was mild and the resolution rate by conservative treatment was rather high. (C) 2002 Elsevier Science B.V. All rights reserved.
  • Y Mizutani, K Kamoi, O Ukimura, A Kawauchi, T Miki
    JOURNAL OF UROLOGY 168 6 2650 - 2654 2002年12月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: Cyclooxygenase-2 (COX-2) is a key inducible enzyme involved in the production of prostaglandins that has been shown to induce apoptosis in various cancer cells. Several anticancer agents also mediate apoptosis and may share the common intracellular pathways leading to apoptosis. Since over expression of COX-2 has been demonstrated in bladder cancer, we reasoned that combination treatment with a COX-2 inhibitor and anticancer agents in bladder cancer cells may result in synergistic apoptosis. We examined whether the selective COX-2 inhibitor JTE-522 induces apoptosis in bladder cancer cells and whether JTE-522 may act synergistically with anticancer agents to achieve cytotoxicity and apoptosis in these cells. Materials and Methods: Cytotoxicity was determined by microculture tetrazolium dye assay. Synergy was assessed by isobolographic analysis. Results: COX-2 mRNA expression was observed in the HT1197 bladder cancer cell line. JTE-522 was cytotoxic in HT1197 cells. Treating HT1197 cells with JTE-522 combined with doxorubicin or mitomycin C did not show synergistic cytotoxicity. However, combination treatment of HT1197 cells with JTE-522 and 5-fluorouracil (5-FU) resulted in a synergistic cytotoxic effect. Synergy was also achieved in the T24 bladder cancer line. Synergistic cytotoxicity was noted irrespective of treatment sequence but the highest percent cytotoxicity was obtained when HT1197 cells were treated with JTE-522 and 5-FU simultaneously. The synergy achieved in cytotoxicity with JTE-522 and 5-FU was shown to be due to apoptosis. The mechanisms responsible for synergistic cytotoxicity and apoptosis was examined. Treating HT1197 cells with 5-FU enhanced expression of the pro-apoptotic molecule Bax, while JTE-522 treatment reduced expression of the anti-apoptotic molecule Bcl-XL, resulting in a significantly higher ratio of Bax-to-Bcl-XL. Conclusions: This study shows that combination treatment of bladder cancer cells with the selective COX-2 inhibitor JTE-522 and 5-FU results in synergistic cytotoxicity and apoptosis due to the enhanced Bax-to-Bcl-XL expression ratio. These findings support the in vivo potential application of a combination of JTE-522 and 5-FU for bladder cancer.
  • N Kanemitsu, A Kawauchi, M Nishida, Y Tanaka, Y Mizutani, S Shirahama, T Miki
    PEDIATRIC NEPHROLOGY 17 12 1063 - 1065 2002年12月 [有り][無し]
     研究論文(学術雑誌) 
    A 10-year-old male referred to our clinic with the chief complaint of nocturnal enuresis also complained of daytime polyuria, frequency, and polydipsia. The clinical diagnosis was central diabetes insipidus. Since the patient's father had complained of similar symptoms, the arginine vasopressin-neurophysin II gene was examined. This revealed a single base substitution in one of two alleles in the patient, his father, and his grandfather (a C to T transition at nucleotide position 280 at codon 19 in the first exon). In conclusion, a history of polyuria or polydipsia should be carefully noted and the urinary volume and urine gravity or osmolarity examined in cases of nocturnal enuresis.
  • H Honjo, A Kawauchi, O Ukimura, J Soh, Y Mizutani, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 9 12 672 - 676 2002年12月 [有り][無し]
     研究論文(学術雑誌) 
    Objective: This study was designed to clarify the clinical usefulness of acupuncture as a treatment option for monosymptomatic nocturnal enuresis, and evaluate the mechanisms of its effect. Methods: Subjects comprised 15 patients (10 males, 5 females) with monosymptomatic nocturnal enuresis who were treated by acupuncture using a disposable stainless steel needle (0.3 mm in diameter, 60 mm in length) inserted into bilateral BL-33 (Zhongliao) points on the skin of the third posterior sacral foramina and rotated manually for 10 min reciprocally. Bladder capacities and number of wet nights per week were compared before and after treatment. Patients in whom wet nights decreased 50% or more compared with the baseline were considered responders. Results: Nocturnal enuresis improvement rates following acupuncture treatment were 40% (6/15) just after treatment and 47% (7/15) 2 months after. In 6 responders, just after treatment the nocturnal bladder capacity (NBC) increased significantly, from 201 mL to 334 mL (P < 0.05). No side-effects were recognized throughout the treatment period. Conclusion: Acupuncture may be beneficial in the treatment of nocturnal enuresis by increasing NBC, and provide a promising alternative to conventional therapies for monosymptomatic nocturnal enuresis.
  • Y Mizutani, O Yoshida, O Ukimura, A Kawauchi, B Bonavida, T Miki
    CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 17 5 563 - 567 2002年10月 [有り][無し]
     研究論文(学術雑誌) 
    Recurrence after transurethral resection is one of the major problems in the treatment of superficial bladder cancer. However, there are no potent prognostic markers for recurrence in superficial bladder cancer at present. As circulating soluble Fas (sFas) and soluble Fas ligand (sFasL) have been implicated in protection from Fas-mediated apoptosis against cancers and may interfere with immune surveillance against autologous cancers, sFas and sFasL in the serum of patients with Ta bladder cancer were evaluated as prognostic tumor markers for recurrence. The serum levels of sFas and sFasL were measured by an enzyme-linked immunosorbent assay. Patients with Ta bladder cancer with low serum levels of both sFas and sFasL had a significantly longer postoperative tumor free interval than those with high serum level of either sFas or sFasL in the 3-year follow-up. There was no correlation between the serum levels of sFas and sFasL. The present study has demonstrated that elevated serum sFas or sFasL predicts early recurrence in patients with Ta bladder cancer. These findings suggest that the serum levels of sFas and sFasL can be used as a prognostic indicator for recurrence in patients with Ta bladder cancer, and that sFas and sFasL may independently inhibit Fas-mediated apoptosis.
  • A Kawauchi, A Fujito, O Ukimura, J Soh, Y Mizutani, Y Imaide, T Miki
    INTERNATIONAL JOURNAL OF UROLOGY 9 9 480 - 484 2002年09月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To report our initial experience of hand-assisted retroperitoneoscopic radical nephrectomy for stage T1 renal tumors. Methods: The clinical data on 22 consecutive patients who had undergone hand-assisted retroperitoneoscopic radical nephrectomy and 22 who had undergone open radical nephrectomy were reviewed. The operation was performed with a hand placed retroperitoneally through a pararectal longitudal 7-7.5 cm incision using a LAP DISC. Results: The total operating time was between 2.3 and 5.8 h (mean: 3.4 h). The estimated blood loss was between 15 and 650 mL (mean: 170 mL). The complication rate was 9% (2/22). No conversions to open procedure occurred. In comparison to open radical nephrectomy, the operating time was similar (3.4 vs 3.9 h) whereas the estimated blood loss was significantly less in this procedure (170 vs 495 mL). During the convalescence period the patients revealed significantly less postoperative pain, shorter intervals to resuming oral intake and more rapid return to normal activities compared to the open radical nephrectomy patients. Conclusion: Hand-assisted retroperitoneoscopic radical nephrectomy is an effective and safe procedure for T1 renal tumors.
  • Y Naya, J Soh, A Ochiai, Y Mizutani, A Kawauchi, A Fujito, S Ushijima, T Ono, N Iwamoto, T Aoki, N Imada, N Nakamura, C Yabe-Nishimura, T Miki
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH 14 4 213 - 216 2002年08月 [有り][無し]
     研究論文(学術雑誌) 
    Erectile dysfunction (ED) is a common complication of diabetes mellitus. Erythrocyte aldose reductase (AR) has been implicated in a variety of diabetic complications. The subjects were 62 diabetic patients, of whom 25 were treated with hemodialysis (chronic renal failure CRF group) and the remaining 37 did not have chronic renal failure (DM group). The controls were 20 healthy volunteers age-matched to the patients. The level of AR was measured by the quantitative determination kit for AR in all patients and controls. In this study, ED was diagnosed by 5-item version of the International Index of Erectile Function (IIEF-5). The average level of AR in the CRF group was significantly higher than that in the DM group and controls (P < 0.001). The average level of AR in the DM group without ED was significantly lower than that in the DM group with ED and controls (P < 0.005). These results suggest that the level of AR may be a useful modality for prediction of ED in diabetic patients.
  • Y Naya, J Soh, A Ochiai, Y Mizutani, S Ushijima, M Kamoi, O Ukimura, A Kawauchi, A Fujito, T Ono, N Iwamoto, T Aoki, N Imada, K Marumo, M Murai, T Miki
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH 14 3 172 - 177 2002年06月 [有り][無し]
     研究論文(学術雑誌) 
    In order to evaluate the erectile function in male renal failure patients treated with hemodialysis (HD), we investigated the International Index of Erectile Function (IIEF) in patients and healthy controls. The subjects were 174 male patients treated with HD, of whom 43 had diabetes mellitus (DM) and the remaining 131 patients did not have DM. The controls were 1133 healthy males. We evaluated the prevalence of erectile dysfunction (ED) using the erectile function (EF) score, which is one of the five domains of the IIEF, in each age group (upto 39 y old, 40-49 y old, 50-59 y old, 60-69 y old). The severity of ED was classified into five categories using EF in each age group. The univariate logistic regression analysis and multiple variate analysis of IIEF in HD patients were performed. The prevalence of ED in HD patients was significantly higher than that in the controls in each age group. The severity of ED in HD patients was also significantly higher than that in the controls in each age group. In the logistic regression analysis and multiple variate analysis of IIEF in HD patients, DM and age were significant risk factors on sexual dysfunction. ED was more prevalent in male renal failure patients treated with HD than in the controls. In the patient group, ED was more prevalent in older DM patients.
  • Y Tanaka, Y Koyama, E Jodo, Y Kayama, A Kawauchi, O Ukimura, T Miki
    PSYCHIATRY AND CLINICAL NEUROSCIENCES 56 3 249 - 250 2002年06月 [有り][無し]
     研究論文(学術雑誌) 
    Using urethane-anaesthetized rats, the effects of acupunctural stimulation to the sacral segment on the urinary bladder activity and cortical electroencephalogram (EEG) were examined. The acupuncture suppressed urinary bladder activity in 36 of 68 trials. On many occasions (22/36 trials), suppression was accompanied by an increase in EEG amplitude. In such cases, the EEG power increased in all frequency bands after stimulation. The same EEG changes could be induced when the bladder was empty with no contraction. The results suggest that acupuncture stimulation affects both the bladder activity and sleep-arousal system.
  • Y Mizutani, N Sato, A Kawauchi, N Nonomura, M Fukushima, T Miki
    BJU INTERNATIONAL 89 4 454 - 458 2002年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objective To investigate the differentiation of embryonal carcinoma (EC) by cisplatin, and the underlying mechanism, as untreated metastases of nonseminomatous germ cell tumours rarely consist of fully differentiated mature somatic tissues, but such mature metastases are more common after various treatments, including chemotherapy. Materials and methods The TTSC-3 human testicular EC line heterotransplanted into nude mice was used as a target. After treating tumour-bearing mice with intraperitoneal injections of varying doses of cisplatin, the histopathology of the tumours was assessed and various gene expressions in the tumours determined by cDNA-array technology. Results When cisplatin at 1 mg/kg/week was injected intraperitoncally into TTSC-3-bearing mice, there was no effect on tumour growth. However, injecting cisplatin at 5 mg/kg/week induced a marked regression of the tumour. In contrast, cisplatin at 3 mg/kg/week had a modest inhibitory effect on tumour growth and induced tumour dormancy. Histological examination showed that 5 weeks after injecting cisplatin (3 mg/kg/week), primitive mesenchymal-like cells increased, and 10 weeks afterward cartilage and well-developed glands (teratoma) were apparent; at > 15 weeks afterward there were no EC cells visible. cDNA probes from reverse-transcribed mRNAs of TTSC-3 treated with cisplatin or saline for 10 weeks were compared to identify genes differentially expressed in cisplatin-treated TTSC-3. Of 1176 different human cDNA transcripts in cisplatin-treated TTSC-3, three genes (tumour necrosis factor receptor 1, caspase 8 and Apaf1), which are associated with apoptosis, were expressed markedly more than after saline injection. Conclusions The intermediate dose of cisplatin inhibited tumour growth of EC by inducing differentiation and enhancing apoptosis-related gene expression. These findings suggest that cisplatin may play a significant role in the differentiation of EC in vivo.
  • Y Mizutani, H Wada, O Yoshida, M Fukushima, B Bonavida, A Kawauchi, T Miki
    ONCOLOGY REPORTS 9 2 289 - 292 2002年03月 [有り][無し]
     研究論文(学術雑誌) 
    There is no potent prognostic marker for recurrence in superficial bladder cancer at present. Thymidylate synthase (TS) is a key enzyme for pyrimidine synthesis. Dihydropyrimidine dehydrogenase (DPD) is an important pyrimidine salvage enzyme. We evaluated a combination of TS and DPD activities as a prognostic marker for recurrence in grade 1 and 2 superficial bladder cancer. The levels of TS and DPD activities in non-fixed fresh frozen bladder cancer specimens were determined biochemically by the 5-fluoro-2'-deoxyuridine 5-monophosphate binding assay and the 5-fluorouracil degradation assay, respectively. Significantly, patients with low TS activity and high DPD activity had a longer postoperative tumor-free interval than those with either high TS activity or low DPD activity in the 2-year follow-up. There were no statistical differences observed in patient's sex and age as well as the histologic stage and grade of bladder cancer between the two groups. In addition, there is no correlation between TS and DPD activities. The present study suggests that a combination of TS and DPD activities may be an independent prognostic indicator for recurrence in grade 1 and 2 superficial bladder cancer, and that either high TS activity or low DPD activity predicts early recurrence.
  • A Kawauchi, Y Yamao, H Nakanishi, Y Naito, Y Tanaka, O Ukimura, Y Mizutani, T Miki
    UROLOGY 59 3 433 - 437 2002年03月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To evaluate the relationships among nocturnal urinary volume (NUV), bladder capacity, and nocturia in nonenuretic children with and without water load. Methods. We evaluated 72 healthy nonenuretic volunteers. The NUV and bladder capacity were measured for 2 nights at volunteers' homes with and without water load. Results. Of the 72 nonenuretic children, 45 (63%) were classified into the large NUV group in which the NUV with water load was more than the upper limit of the 95% confidence interval of NUV in Japanese nonenuretic children, and the other 27 (37%) were classified into the small NUV group. In the large NUV group, 33 (73%) had one or two episodes of nocturia because of water intake, and 12 (27%) did not. The nocturnal bladder capacity in the latter 12 children was significantly larger than that in the former 33, although no significant differences were found in functional bladder capacity and NUV with water intake. Conclusions. Most nonenuretic children were able to cope with the physiologic loading of water that would cause bedwetting in enuretic children. After water loading, three quarters of the nonenuretic children were able to awake easily because of the need to urinate with a certain volume of urine in the bladder, and the one quarter who did not awake were able to hold more urine in their bladder in the sleep state. UROLOGY 59: 433-437, 2002. (C) 2002, Elsevier Science Inc.
  • Y. Naya, J. Soh, A. Ochiai, Y. Mizutani, S. Ushijima, K. Kamoi, O. Ukimura, A. Kawauchi, A. Fujito, T. Ono, N. Iwamoto, T. Aoki, N. Imada, K. Marumo, M. Murai, T. Miki
    Analog Integrated Circuits and Signal Processing 30 1 51 - 58 2002年 [有り][無し]
     研究論文(学術雑誌) 
    We used a 2.5D EM-simulator to study planar inductor performance in a submicron CMOS technology. We found good agreement between simulations and measurements using only the nominal process parameters for the layer thicknesses, permittivities, and conductivities. By sweeping the thickness and conductivity of the epitaxial layer we show how these parameters affect inductor performance. The presence of a highly conductive substrate layer is shown to have a detrimental effect on inductor performance whereas the thickness and conductivity of the epitaxial layer is less important.
  • Ukimura O, Kawauchi A, Miki T
    Nihon rinsho. Japanese journal of clinical medicine 60 Suppl 1 577 - 584 2002年01月 [有り][無し]
  • A Kawauchi, Y Tanaka, Y Yamao, M Inaba, M Kanazawa, O Ukimura, Y Mizutani, T Miki
    UROLOGY 58 5 772 - 776 2001年11月 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To evaluate the relationship between bedwetting and development in infancy. Methods. Questionnaires concerning micturition habits and development at 3 and 5 years of age were completed by the parents of 157 children who had had their health checked by pediatricians at a group checkup at 3 years of age. Results. The percentage of bedwetters in whom the frequency of bedwetting was at least once a month was 53% at 3 years of age and 21% at 5 years of age. The prevalent resolution period of bedwetting in infants was 2.5 to 3.5 years of age. The head circumference for boys at birth differed significantly between the bedwetters and nonbedwetters at both ages. Daytime symptoms were more frequent among bedwetters at both ages. Earlier toilet training had no influence on bedwetting at 5 years of age, although it led to earlier control at night at a younger age. Delays in speaking and walking might be factors connected to bedwetting. The prevalence of bedwetting in boys was higher than that in girls. Multiple logistic regression analysis revealed that daytime incontinence and sex were significant factors for bedwetting at 5 years of age. Conclusions. Daytime incontinence and sex were the significant factors for bedwetting in infancy. Head circumference for boys and developmental delays in speaking and walking might also be important factors. (C) 2001, Elsevier Science Inc.
  • M Inaba, O Ukimura, A Kawauchi, T Iwata, M Kanazawa, S Ushijima, A Ochiai, M Kojima, T Miki
    ULTRASOUND IN MEDICINE AND BIOLOGY 27 11 1481 - 1484 2001年11月 [有り][無し]
     研究論文(学術雑誌) 
    The present study was designed to reveal the possible use of ultrasound estimated bladder weight (UEBW) in evaluating vesicoureteral reflux (VUR) in children in terms of possible implication of bladder hypertrophy in VUR. In 27 children with VUR, UEBW was measured by transabdominal ultrasound. The UEBW in an individual patient was evaluated quantitatively using the percent deviation from age matched UEBW. There was a significant difference noted in the percent deviation from age-matched UEBW between patients (n = 17) with primary VUR and those (n = 10) with secondary VUR (p < .05). When analyzed together in 27 patients, a significant positive correlation (p < .05) was recognized between the percent deviation from age-matched UEBW and VUR grade. This was also the case in ten patients with secondary VUR (p < .01), but not for 17 patients with primary VUR. The measurement of UEBW might be of clinical use in evaluating the pathogenesis as well as the severity of VUR in children. (C) 2001 World Federation for Ultrasound in Medicine & Biology.
  • Terukazu Nakamura, Shinichi Mitsui, Akira Okui, Katsuya Kominami, Takeshi Nomoto, Osamu Ukimura, Akihiro Kawauchi, Tsuneharu Miki, Nozomi Yamaguchi
    Prostate 49 1 72 - 78 2001年09月 [有り][無し]
     研究論文(学術雑誌) 
    BACKGROUND. Hippostasin is a kallikrein-like protease (PRSS20/KLK11), which is expressed preferentially in the hippocampus and prostate. We have reported that alternative splicing variants of human hippostasin are regulated in a tissue-specific manner. Brain-type hippostasin consists of 250 amino acids including a typical signal sequence, and is expressed in the brain and prostate. The prostate-type hippostasin, which has 32 extra amino acids at the N-terminal end, is expressed only in the prostate. METHODS. We analyzed the expression and localization of hippostasin in normal prostate tissue, BPH tissue, and prostate cancer cell lines. We performed northern blotting, in situ hybridization, immunohistochemistry, and RT-PCR. RESULTS. Hippostasin mRNA is expressed preferentially in the normal prostate and weakly in the testis. It was detected in prostate secretory epithelium. Hippostasin protein was localized in the prostate secretory epithelium, and western blotting showed that hippostasin was present in semen. All tested prostate cancer cell lines, including PSA-negative cell lines, expressed hippostasin. Interestingly, all the prostate cancer cell lines expressed only braintype but not prostate-type hippostasin, while normal prostate and BPH expressed both types of hippostasin CONCLUSIONS. Our results suggest the possibility that hippostasin may be a useful marker by which prostate cancer and BPH can be distinguished. © 2001 Wiley-Liss, Inc.
  • A Kawauchi, Y Yamao, O Ukimura, K Kamoi, J Soh, T Miki
    JOURNAL OF UROLOGY 165 6 2010 - 2012 2001年06月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: We clarified the relationships of the renal resistive index, reflux and renal scarring. Materials and Methods: The resistive index in the interlobar artery was measured using power Doppler ultrasonography in 22 patients with reflux (reflux group), 13 with postoperative or resolved reflux (previous reflux group) and 20 who served as controls. Results: Resistive index values in 11 kidneys with mid or high grade reflux were significantly higher than in 22 with low grade reflux and in the 40 normal kidneys. The resistive index in the 11 kidneys with reflux and scarring was significantly higher than in the 22 with reflux and without scarring, and in the 40 normal kidneys. The resistive index in the 14 kidneys with previous reflux and scarring was significantly higher than in 12 with previous reflux and without scarring, and in the 40 normal kidneys. Receiver operating characteristics curve analysis in 25 kidneys with and 34 without scarring revealed that a discriminatory resistive index value of 0.71 was optimal for detecting renal scarring. When the resistive index cutoff value was 0.71, there was 76% sensitivity for diagnosing renal scarring, 91% specificity and 85% overall accuracy. Conclusions: Our results show the possibility that an increased resistive index in kidneys with reflux predicts renal scarring. The resistive index measured with power Doppler ultrasonography may be a noninvasive and useful alternative for screening and following renal scarring.
  • Akihiro Kawauchi, Shiro Takahara, Masaharu Sada, Rieko Goto, Takeshi Nakatani, Tsuneharu Miki
    Urology 58 6 1036 - 1039 2001年 [有り][無し]
     研究論文(学術雑誌) 
    Objectives. To determine whether vesicoureteral reflux is associated with the human leukocyte antigen (HLA) genes. Methods. We evaluated 40 Japanese patients (27 males and 13 females) with reflux. HLA-DR low-resolution genotyping and high-resolution typing of HLA-DRB1 alleles were performed. The frequencies of the HLAs and alleles were calculated and compared with those previously reported in 493 healthy Japanese. Results. Low-resolution typing showed that the frequency of the HLA-DR11 antigen was significantly higher in the patients with reflux than in the control group. High-resolution typing revealed that the frequencies of HLA-DRB1 * 1101 and 1502 alleles were significantly higher in the patients with reflux than in the control group. In the patients with and without renal scarring, the frequencies of the HLA-DR11 antigens and HLA-DRB1 * 1101 alleles were significantly lower in those with renal scarring. In the patients with and without the chief complaint of urinary tract infection symptoms, the frequencies of HLA-DR13 antigens and HLA-DRB1 * 1302 alleles were significantly lower in those with that chief complaint. Conclusions. The susceptibility to reflux is, in part, controlled by HLA genes themselves or an unknown gene or genes, the locus for which is located close to the DRB1 gene. The lack of a HLA-DRB1 * 1101 allele and DRB1 * 1302 allele in patients with reflux might be connected with renal scarring and urinary tract infection, respectively. © 2001, Elsevier Science Inc.
  • M Kanazawa, O Ukimura, S Ushijima, M Inaba, T Iwata, F Hongo, K Kamoi, A Kawauchi, M Nakao, H Ohe, T Miki
    PROCEEDINGS OF THE 6TH CONGRESS OF THE ASIAN FEDERATION OF SOCIETIES FOR ULTRASOUND IN MEDICINE AND BIOLOGY 207 - 210 2001年 [有り][無し]
     研究論文(国際会議プロシーディングス) 
    In patient who refused open surgery, percutaneous cryosurgery of renal oncocytoma, using ultrasonic monitoring was performed. During the operation, no toxicity associated with cryosurgery was found. Follow-up US and CT imaging demonstrated no evidence of residual or recurrent disease and the patient was, alive and well I year after the ablation.
  • S Ushijima, O Ukimura, M Kanazawa, M Inaba, T Iwata, F Hongo, K Kamoi, A Kawauchi, M Nakao, T Miki
    PROCEEDINGS OF THE 6TH CONGRESS OF THE ASIAN FEDERATION OF SOCIETIES FOR ULTRASOUND IN MEDICINE AND BIOLOGY 245 - 249 2001年 [有り][無し]
     研究論文(国際会議プロシーディングス) 
    In patients who have significant operative risk, percutaneous radiofrequency interstitial tumor ablation (RITA) of renal cell carcinoma using ultrasonic monitoring was performed. During as well as after ablation, multiple echogenic foci with acoustic shadowing within the treatment area were considered to be compatible with microbubble formation accompanied by degeneration of tissues.
  • N Imada, Y Koyama, A Kawauchi, H Watanabe, Y Kayama
    JOURNAL OF UROLOGY 164 5 1740 - 1744 2000年11月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: The precise mechanism by which normal persons wake upon urinary sensation is unclear. The locus caeruleus in the pens is suggested to be involved in the activating systems for arousal. We evaluated the effects of bladder distention on the neural activity in the l. caeruleus under different states of anesthesia. Materials and Methods: Experiments were performed on 20 male Sprague-Dawley rats. The spontaneous discharge rate of single neurons in and around the l. caeruleus was recorded with the rat under urethane anesthesia administered intraperitoneally, while the electroencephalogram was monitored simultaneously. The changes of the discharge rate of the neurons were observed during saline infusion into the bladder or during tail pinch stimulation. After recording the location of the neurons was confirmed histologically. Results: Of 42 l. coeruleus neurons whose response was examined during deep anesthesia 31 showed an excitatory response to bladder distention, followed by a change in electroencephalogram pattern to a faster and smaller rate, while the remaining 11 showed no response. Of 28 l. coeruleus neurons examined during light anesthesia only 1 neuron was excited and the remaining 27 showed no response. Virtually all of the l. coeruleus neurons unresponsive to bladder distention were responsive to tail pinch stimulation. Of the nonnoradrenergic neurons ventromedial to the l. coeruleus 4 of 7 during deep anesthesia and 5 of 8 during light anesthesia showed an excitatory response to distention. Conclusions: The excitatory response of the l. coeruleus neurons to bladder distention was strongly affected by the state of anesthesia. The response was observed only during deep anesthesia and was accompanied by lightening of the anesthesia. L. coeruleus may be involved in arousal which is mediated by bladder distention.
  • Y Yamao, Y Koyama, A Kawauchi, E Jodo, Y Kayama, T Miki
    PSYCHIATRY AND CLINICAL NEUROSCIENCES 54 3 259 - 261 2000年06月 [有り][無し]
     研究論文(学術雑誌) 
    To clarify a relation between contractile condition of the urinary bladder and vigilance condition, bladder pressure was monitored simultaneously with cortical electroencephalogram (EEG) in urethane-anesthetized rats. Slow waves of large amplitude and those of lower amplitude appeared in EEG alternately. The bladder showed no contractile activity in the former EEG condition, while it contracted intermittently or continuously to urinate in the latter EEG-condition. The relative power of EEG delta waves was significantly different in these two conditions. These results suggest that activity of the micturition system changes according to vigilance conditions, which may serve to prevent enuresis during sleep.
  • A Kawauchi, Y Tanaka, J Soh, O Ukimura, M Kojima, T Miki
    JOURNAL OF UROLOGY 163 1 81 - 84 2000年01月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: We investigate the causes of nocturnal urinary frequency and reasons for its increase with age. Materials and Methods: All voided volumes and times were recorded for 3 days in 188 healthy older men without prostatic diseases during a mass screening program for prostatic diseases in Japan. Nocturnal urinary frequency for each night was defined as the frequency during sleep not counting the morning void. Relationships between nocturnal urinary frequency and functional bladder capacity, nocturnal bladder capacity, nocturnal urinary volume and sleep time were analyzed, Age related changes in functional and nocturnal bladder capacity, and nocturnal and diurnal urinary volume were evaluated. Results: Multiple regression analysis demonstrated nocturnal bladder capacity and urinary volume to be significant independent determinants of nocturnal frequency. In age related analysis nocturnal bladder capacity and diurnal urinary volume decreased with age, while nocturnal urinary volume did not change. Conclusions: Nocturnal urinary volume and nocturnal bladder capacity were the significant determinants of nocturnal urinary frequency in healthy older men. The increase of nocturnal frequency with age was thought to be due to a decrease in nocturnal bladder capacity, since urinary volume did not change, In older men a decrease in water intake might influence age related changes in urinary volume.
  • Y Koyama, N Imada, A Kawauchi, Y Kayama
    BRAIN RESEARCH 840 1-2 45 - 55 1999年09月 [有り][無し]
     研究論文(学術雑誌) 
    The relation between unit activity in the laterodorsal tegmental (LDT) area and the state of the urinary bladder was examined in urethane-anesthetized rats. Neurons in the LDT area can be classified into two populations: broad-spike (possibly cholinergic) and brief-spike (non-cholinergic). When the rats showed cortical electroencephalographic activity with large amplitude lower frequency, indicative of deep anesthesia, more than 40% of the broad-spike neurons was excited and about 10% was inhibited by infusion of saline into the bladder. The response was followed by decrease in amplitude and slight increase in frequency of the cortical activity, i.e., lightening of anesthesia. During light anesthesia, excitation was observed only in less than 10% of the units, while 17% was inhibited. In the brief-spike neurons, a similar proportion (about 20%) was excited and less than 10% was inhibited by the distention during either state of anesthesia. About 10% of the broad-spike neurons in the LDT area and 30% of the brief-spike neurons examined were discharged prior to the bladder contraction. Such neurons of the brief-spike category were encountered frequently outside of the central gray; lateral, caudal and ventral to the main mass of cholinergic neurons in the LDT area. These results suggest the possible involvement of the broad-spike (cholinergic) neurons in the elevation of vigilance level caused by bladder distention. The brief-spike (non-cholinergic) neurons firing with relation to bladder contraction may be part of the micturition reflex center. (C) 1999 Elsevier Science B.V. All rights reserved.
  • Y Kumano, M Ishii, H Nishida, M Sakamoto, K Sasaki, A Kawauchi, K Mitamura
    HEPATOLOGY RESEARCH 15 3 201 - 214 1999年08月 [有り][無し]
     研究論文(学術雑誌) 
    Doppler ultrasonography was used to measure hepatic hemodynamics in patients with chronic liver disease. We investigated the relationships among the velocity of renal arterial blood flow by Doppler ultrasonography, neurohormonal parameters and human atrial natriuretic peptide (hANP) in chronic liver disease. These parameters were measured in 45 patients with chronic liver disease (15 patients with chronic hepatitis and 30 patients with liver cirrhosis) and 16 healthy subjects. Patients with liver cirrhosis were classified into nine patients with ascites responsive to the conventional treatment, one with refractory ascites and 20 without ascites. Renal arterial velocity was obtained from measurements in the main renal artery (RA) in the cortex. The resistive index (RI) (= (peak systolic velocity - minimum diastolic velocity)/peak systolic velocity) in different areas of the kidney was significantly higher in patients with liver cirrhosis than in patients with chronic hepatitis and healthy subjects. Among cirrhotic patients, RI was higher in patients with ascites than in those without ascites. The RI decreased from the hilum of the kidney to the outer parencayma in both patients with chronic liver disease and healthy subjects. Neurohormonal parameters tended to be higher but this difference was not significant in patients with liver cirrhosis, especially in those with ascites. Serum hANP levels were positively correlated with main renal arterial RI (r = 0.728, P < 0.5), segmental arterial RI (r = 0.729, P < 0.05), interlobar arterial RI (r = 0.919, P = 0.001) and interlobular aterial RI (r = 0.720, P < 0.05) in cirrhotic patients with ascites but no correlation was found with the RI of the peripheral artery in the cortex. On the other hand, in patients without ascites, serum hANP was positively correlated with renal arterial RI, even with the RI of the cortical artery. In addition to measurement of hANP, measurement of renal arterial RI from the hilum to the cortical artery of the kidney by Doppler ultrasonography is beneficial for differentiating stage between with and without ascites in liver cirrhosis and for evaluating changes in systemic and renal hemodynamics. Neurohormonal parameters and hANP were related to the presence or absence of liver cirrhosis. The serum level of hANP is useful for estimating hyperdynamic circulation in liver cirrhosis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
  • Y Yamao, A Kawauchi, Y Tanaka, H Watanabe, T Kitamori, N Imada, S Shirakawa
    PSYCHIATRY AND CLINICAL NEUROSCIENCES 53 2 277 - 278 1999年04月 [有り][無し]
     研究論文(学術雑誌) 
    Seven patients complaining of nocturnal urinary frequency were treated following a sleep-micturition chart. By clinical analysis of the data, the causes of nocturnal urinary frequency were divided into three diagnostic categories: a small bladder capacity group, a sleep disorder group and a large nocturnal urinary volume group. The three groups were treated by anticholinergic agents, sleeping pills and restriction of water intake at night respectively. With the administration of anti-cholinergic agents or sleeping pills nocturnal bladder capacity increased. By restriction of water intake at night nocturnal urinary volume decreased. In all patients nocturnal urinary frequency decreased and sleep efficiency was improved.
  • Hiroki Watanabe, Akihiro Kawauchi
    Scandinavian Journal of Urology and Nephrology, Supplement 33 202 14 - 17 1999年 [有り][無し]
     研究論文(国際会議プロシーディングス) 
    There are four neuronal networks projecting to many areas of the brain. All networks relate closely to arousal and sleep function. Among the four networks, the noradrenaline projection network, originating from the locus coeruleus (LC), is the system most typically responsible for arousal. This study shows that the LC is activated by the stimulation of bladder distension only while the patient is in deep sleep, not in light sleep. This finding corresponds with the mechanism of enuresis type I in our classification of enuresis, based on overnight simultaneous monitoring using electroencephalography and cystometry. The importance of arousal and sleep systems in the pathogenesis of enuresis is also discussed.
  • H Watanabe, A Kawauchi
    SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 33 14 - 19 1999年 [有り][無し]
     研究論文(学術雑誌) 
    There are four neuronal networks projecting to many areas of the brain. All networks relate closely to arousal and sleep function. Among the four networks, the noradrenaline projection network, originating from the locus coeruleus (LC), is the system most typically responsible for arousal. This study shows that the LC is activated by the stimulation of bladder distension only while the patient is in deep sleep, not in light sleep. This finding corresponds with the mechanism of enuresis type I in our classification of enuresis, based on overnight simultaneous monitoring using electroencephalography and cystometry. The importance of arousal and sleep systems in the pathogenesis of enuresis is also discussed.
  • O Ukimura, M Kojima, E Inui, A Ochiai, Y Naya, A Kawauchi, H Watanabe
    JOURNAL OF UROLOGY 160 4 1459 - 1462 1998年10月 [有り][無し]
     研究論文(学術雑誌) 
    Purpose: In healthy children as well as those with urinary disturbance we determined ultrasound estimated bladder weight with the aim of revealing its possible usefulness as a measure of bladder compliance. Materials and Methods: We measured ultrasound estimated bladder weight in 71 healthy children with a mean age of 10.3 years, and determined a standard value. A total of 82 patients with a mean age of 9.6 years with urinary disturbance also underwent ultrasound estimated bladder weight measurement as well as conventional urological examinations, including filling cystometry. Results: In healthy children ultrasound estimated bladder weight increased with age, showing a significant linear correlation (r = 0.80, p <0.0001). Using the formula for linear correlation, 0.86 x patient age + 6.9 gm., we obtained an age matched estimated weight. In 82 patients the percent deviation of the estimate from age matched values was calculated using the formula, (measured ultrasound estimated bladder weight -age matched ultrasound estimated bladder weight)/age matched ultrasound estimated bladder weight x 100, and then correlated with bladder compliance. In 75 of 77 patients (97%) with compliance of 10 ml./cm. water or more the estimate was within 100% deviation. In contrast, 4 of 5 patients (80%) with a low compliant bladder (less than 10 ml,/cm. water) had an ultrasound estimated bladder weight greater than 100% deviation. When the estimate was within 100% deviation, all but 1 patient (75 of 76, 98.7%) had compliance of 10 ml./cm. water or more compared to 33.3% (2 of 6) of those with an estimate greater than 100% deviation. As a result, with the use of a cutoff value of 100% deviation ultrasound estimated bladder weight predicted a low compliant bladder with a diagnostic accuracy as high as 96.3% (79 of 82 cases). Conclusions: Ultrasound estimated bladder weight may be used to evaluate bladder compliance in children. It seems to be a suitable noninvasive urodynamic test in children with suspected urodynamic abnormalities.
  • N Imada, A Kawauchi, Y Tanaka, H Watanabe
    BRITISH JOURNAL OF UROLOGY 81 107 - 108 1998年05月 [有り][無し]
     研究論文(学術雑誌) 
    Objective To assess urinary incontinence objectively in children, Patients and methods Thirty-three children (mean age 8.2 years, range 5-12) were examined, of whom 23 suffered from incontinence and 10 did not. The first method of assessing incontinence was the 1-h pad-weighing test proposed by the International Continence Society in 1983 and the second was a test in which the pad was weighed between one urination and the next. At the end of the tests the volume of normally voided urine was measured and the total voided volume during the test calculated. The volume of urine lost during incontinence and the ratio [incontinence volume/(incontinence volume + voided volume)] were evaluated; the ratio was used because the bladder capacity in children differed with age. Results In both tests, no wetting occurred in any of the 10 patients not complaining of incontinence, In the 1-h pad-weighing test, no wetting occurred in 14 of the 23 patients complaining of incontinence but did in the nine remaining patients, the loss being 1-30 g, and the incontinence ratio 0.5-14.8%. In the second test, no wetting occurred in 12 of the 23 patients complaining of incontinence but did so in the 11 remaining patients, with losses of 2-50 g and incontinence ratios of 1.5-80.6%. Conclusions There was no significant difference between the tests in the incidence of incontinence. However, the second method seemed to be more closely related to the clinical symptoms than was the 1-h pad-weighing test and may be useful in the assessment of incontinence in children.
  • Y Tanaka, A Kawauchi, H Watanabe, N Imada
    PSYCHIATRY AND CLINICAL NEUROSCIENCES 52 2 189 - 190 1998年04月 [有り][無し]
     研究論文(学術雑誌) 
    The relationship between nocturnal urinary frequency and sleep disturbances is investigated in aged men in 12. rural towns in Kyoto and Shiga Prefectures. The subjects were 178 men who did not have diseases or symptoms that were likely to affect urinary condition or sleep. There were no significant differences in sleep disturbances, except sleep maintenance, between the normal group (nocturnal urinary frequency below twice per night) and the abnormal group (nocturnal urinary frequency twice or more per night). In healthy aged men, nocturnal urinary frequency only caused disturbance in sleep maintenance, but did not cause any other sleep disturbance.
  • Y Koyama, N Imada, Y Kayama, A Kawauchi, H Watanabe
    PSYCHIATRY AND CLINICAL NEUROSCIENCES 52 2 142 - 145 1998年04月 [有り][無し]
     研究論文(学術雑誌) 
    Under urethane anesthesia, the urinary bladder of male rats was distended by 0.3-0.5 mL of saline. When the animals displayed large amplitude delta waves, the distention caused tonic excitation in 76% (19/25) of the noradrenergic neurons in the locus coeruleus and in 53% (16/30) of the cholinergic neurons in the laterodorsal GRAPHICS tegmental nucleus. The response was followed by a shift of electroencephalogram (EEG) pattern to faster waves of smaller amplitude. When EEG amplitude was faster and smaller, the same stimuli caused no response. Neurons in Barrington's nucleus were excited by a small amount of bladder distention independent of EEG patterns. These results suggest that the transition of state, caused by bladder distention, from deep sleep to light sleep is mediated by noradrenergic and cholinergic neurons in the brainstem.
  • A. Kawauchi, N. Imada, Y. Tanaka, M. Minami, H. Watanabe, S. Shirakawa
    British Journal of Urology, Supplement 81 3 72 - 75 1998年 [有り][無し]
     研究論文(国際会議プロシーディングス) 
    Objective. To evaluate the mechanism if the dysfunction of arousal in patients with Type I and Type IIa enuresis. Patients and methods. The numbers of sleep spindles and delta waves were analysed during electroencephalography in 19 patients with enuresis (17 male, two female, mean age 9-7 years, range 8-14). Results. In four patients with Type I enuresis, who awoke spontaneously and remained dry as a result of urinary sensation, the numbers of sleep spindles and delta waves diminished gradually and finally disappeared just before the patients awoke completely. In the remaining nine patients with Type I enuresis, there was no decrease in the number of sleep spindles and delta waves, and enuresus occurred without the subjects awakening. In the six patients with Type IIa enuresis, there was no arousal reaction or generation of sleep spindles on urination while asleep. Conclusions. An immaturity in the function of the thalamus might be a cause of the arousal dysfunction in patients with Type I enuresis. In Type IIa enuresis, a possible abnormal or immature arousal mechanism in the pons or the lower tract may be responsible.
  • N Imada, A Kawauchi, Y Tanaka, Y Yamao, H Watanabe, Y Takeuchi
    EUROPEAN UROLOGY 33 45 - 48 1998年 [有り][無し]
     研究論文(学術雑誌) 
    Objectives: To evaluate the features of the clinical findings in three types (types I, IIa, IIb) of enuresis, classified by overnight simultaneous monitoring by electroencephalography (EEG) and cystometry (CM). Methods: We performed a test to evaluate bladder capacity, arousal response and the pattern of nighttime urination in sucklings and infants. Results: As for the values of enuretic bladder capacity (EBC), the smallest were found in enuresis type Ire. As for arousal response, enuresis type I showed the best, while enuresis type IIa showed the worst response. With regard to the pattern of nighttime urination in sucklings and infants, all sucklings had a stable bladder in the sleep state and urinated in the pattern of type IIa. The arousal response to bladder distention indicating type I appeared at the age of about 2 or 3. Conclusions: The smallest EBC in patients with enuresis type IIb represented a bladder dysfunction in the sleep period. It was observed that patients with enuresis type I had the best arousal function while those with enuresis type IIa had the worst arousal function. All sucklings urinated unconsciously during sleep in the pattern of type IIa. The arousal response to bladder distention indicating type I, which was not observed below the age of 1 year, was thought to appear at the age of about 2 or 3 years. If this change has not appeared by the age of 3, bed-wetting might persist after the age of 5.
  • H. Watanabe, N. Imada, A. Kawauchi, Y. Koyama, S. Shirakawa
    Scandinavian Journal of Urology and Nephrology, Supplement 31 183 7 - 10 1997年 [有り][無し]
     研究論文(国際会議プロシーディングス) 
    The physiological background of enuresis Type I, which is due to a mild arousal dysfunction, has been investigated in two studies, one in rats and one in children with Type I enuresis. The results of these investigations suggest that in this type of enuresis, the fundamental arousal function following bladder distension, due to an arousal centre like the locus coeruleus and its network, is normal. In contrast, the process of multiplying the transient connection from light sleep to complete awakening, which probably relies upon functions of the thalamus and the further upper centrums, was thought to be abnormal.
  • H Watanabe, N Imada, A Kawauchi, Y Koyama, S Shirakawa
    SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 31 7 - 10 1997年 [有り][無し]
     研究論文(学術雑誌) 
    The physiological background of enuresis Type I, which is due to a mild arousal dysfunction, has been investigated in two studies, one in rats and one in children with Type I enuresis. The results of these investigations suggest that in this type of enuresis, the fundamental arousal function following bladder distension, due to an arousal centre like the locus coeruleus and its network, is normal. In contrast, the process of multiplying the transient connection from light sleep to complete awakening, which probably relies upon functions of the thalamus and the further upper centrums, was thought to be abnormal.
  • Naoki Imada, Akihiro Kawauchi, Tomohito Kitamori, Takuji Ohne, Yoshiyuki Tanaka, Hiroki Watanabe
    Japanese Journal of Urology 87 9 1114 - 1119 1996年 [有り][無し]
     研究論文(学術雑誌) 
    (Background) The long-term results of systematic treatment based on overnight simultaneous monitoring of electroencephalography (EEG) and cystometry in the patients with enuresis were evaluated. (Methods) From January to December, a total of 213 patients were classified into 3 types. Enuresis Type IIa such cases show a normal CMG without an awakening response on the EEG. Enuresis Type IIb such cases show an abnormal CMG with no awakening response on the EEG. When such cases enter the deep sleep stage, continuous uninhibited contractions of the bladder are observed on the CMG. 136 cases were of Type I, 20 cases of Type IIa, and 57 cases of Type IIb. (Results) Out of 213 patients who were followed up for 2 years, cured cases were 94 (44%), effective cases were 81 (38%) and unchanged cases were 38 (18%). In 136 patients with Type I, cured cases were 71 (52%), effective cases were 50 (37%) and unchanged cases were 15 (11%). In 20 patients with Type IIa, cured cases were 8 (40%), effective cases were 9 (45%) and unchanged cases were 3 (15%). In 57 patients with Type IIb, cured cases were 15 (26%), effective cases were 22 (39%) and unchanged cases were 20 (35%). The age of the effective group, which included cured cases and effective cases, was significantly higher than that of the unchanged group. In enuresis Type I, the percentage of the patients with incontinence in daytime were significantly in the unchanged group than in the effective group. No significant differences in the frequency of enuresis and the percentage of the patients who had awakened spontaneously by urinary sensation were found between the two groups. (Conclusions) The therapeutic response was best in enuresis Type I and worst in enuresis Type IIb. The patients in whom not only frequency of enuresis but also type of enuresis was unchanged by systematic treatment for two years, was approximately 10% across the types. Accordingly they were thought to be non-responders to this systematic treatment.
  • Terumasa Sawada, Kentaroh Kamiya, Akihiro Kawauchi, Toshiyuki Shiga
    Journal of The Showa Medical Association 55 3 269 - 277 1995年 [有り][無し]
     研究論文(学術雑誌) 
    Expression of the c-erbB-2 oncoprotein (ErbB-2) and the p53 gene product was examined in the operative specimen from 68 human breast cancer patients. These patients were detected immunohistochemically by the streptavidin-biotin method using a commercial kit (SABPO kit, Nichirei Co., Inc., Tokyo) and monoclonal anti-mouse antibodies specific for the intracellular domain of the protein. Expression was evaluated as positive when specific membranous staining for c-erbB-2, and nuclear staining for p53, were observed in a majority of cancer cell nets. The expression of the estrogen receptor (ER) as a marker of hormone dependency was also examined serum levels of these two gene products were measured (c-erbB-2: mAb1 Triton Diagnostics Co., Inc. Alameda, CA) (p53: Ab-2 Oncogene Science Co., Inc., Uniondale, NY). Tissue c-erbB-2 and p53 products were positive in 22.1% (15/68), and 25.0% (17/68) of the components, and serum c-erbB-2 and p53 protein levels were positive in 19.1% (13/68) and 7.4% (5/68). Oncoprotein (c-erbB-2 or p53) tissue expression-positive patients showed a tendency to be estrogen receptor negative and 8 cases were positive on p53 protein expression out of 25 scirrhous breast cancer. The data might provide a better characterization of the human breast cancer phenotype, and two expressions of the c-erbB-2 and p53 protein in the tissue would be useful for judgements of prognosis. © 1995, The Showa University Society. All rights reserved.
  • Akihiro Kawauchi, Terunobu Sawada, Hozumi Nagakura, Kenji Kushima, Matsuo Taniyama, Yoshio Ban
    Journal of The Showa Medical Association 55 6 623 - 629 1995年 [有り][無し]
     研究論文(学術雑誌) 
    Endoscopic adrenalectomy with wide endoscope, which was first reported a few years ago, was performed in three cases of left adreno-cortical adenoma with hypertension. The patient was a was 59-year-old man and 53- and 54-year-old women. The size of tumor in each patient was approximately 2 cm. Intraoperative blood loss during wide endoscopic adrenalectomy was ranged from 128 to 313 ml, and duration of surgery ranged from 2 to 4 hours. The length of the skin incisions in each case was 5 cm. These data show that this new minimally invasive surgical procedure has some benefits compared with conventional open and laparoscopic surgery. In addition, our favorable results suggest that intraorerative ultrasound examination will make it easy to detect small adrenal tomors in the deep retroperitoneal adipose tissue. © 1995, The Showa University Society. All rights reserved.
  • T. Mita, N. Ando, A. Kawauchi, K. Morikawa
    Proceedings of the ASME Turbo Expo 4 1995年 [有り][無し]
     研究論文(国際会議プロシーディングス) 
    A fully-fired combined cycle power plant (FFCCPP) combines a steam thermal power plant with a gas turbine. Hot exhaust gases fed from the gas turbine are used as combustion air for the boiler, thus increasing total plant output and efficiency. An unusually hot spell in Japan in the summer of 1990 brought about such a rapid surge in power demand for air conditioning so that all electric power companies registered record highs in consumption. This promoted Chubu Electric Power Co. to decide to add a 154-MW gas turbine to each of its six existing steam thermal power plants (four 700-MW and two 375-MW units), thus repowering their system into an FFCCPP. Construction work began in 1992. In September, 1994, two 700-MW steam thermal power plants (Chita Thermal Power Plant's No. 6 unit and Chita Second Thermal Power Plant's No. 1 unit) were modified into FFCCPPs, which then began operating in a trouble-free manner. This paper reports the characteristics and test-run results of the above two plants, which have been operating in good condition as the largest-capacity FFCCPPs in the world.
  • H. Watanabe, A. Kawauchi
    Scandinavian Journal of Urology and Nephrology, Supplement 173 37 - 41 1995年 [有り][無し]
     研究論文(国際会議プロシーディングス)
  • H Watanabe, A Kawauchi
    SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 37 - 41 1995年 [有り][無し]
     研究論文(学術雑誌)
  • H. Watanabe, A. Kawauchi
    Scandinavian Journal of Urology and Nephrology, Supplement 163 29 - 38 1994年 [有り][無し]
     研究論文(国際会議プロシーディングス)
  • Seiji Naito, Akihiro Kawauchi, Susumu Ando, Hirotoshi Choh, Nobuhiro Fukunari, Toshiyuki Shiga, Kuniaki Nakayama, Wataru Matsui, Youji Ito, Chun Jen Lee, Kentaro Kamiya, Tadashi Koike
    Journal of The Showa Medical Association 50 5 553 - 556 1990年 [有り][無し]
     研究論文(学術雑誌) 
    A 22-year-old man experienced a traumatic deep submandibular foreignbody in a traffic accident. Roentgenogram did not indicate its position clearly, and extraction was tried three times with no success. On using 7.5 MHz high speed mechanical sector scanner, the foreignbody was removed easily. The mechanical sector scanner and linear electric scanner can produce real time images, but they are not available for superficial tissue. In this case a mechanical arch scanner was used because of the advantage of its high resolution when use on superficial tissue. © 1990, The Showa University Society. All rights reserved.
  • M UCHIDA, H WATANABE, Y NAKAGAWA, A FUJITO, K KITAMURA, Y IMAIDE, A KAWAUCHI
    JOURNAL OF UROLOGY 139 2 263 - 265 1988年02月 [有り][無し]
     研究論文(学術雑誌)
  • Akihiro Kawauchi, Hiroki Watanabe, Mutsumi Uchida, Yuji Nakagawa, Akira Fujito, Koji Kitamura, Yoichiro Imaide
    Japanese journal of medical electronics and biological engineering 26 2 126 - 128 1988年 [有り][無し]
     研究論文(学術雑誌) 
    A possibility was evaluated experimentally on the capsulization of expansive splitter to prevent the urinary mucosa from alkalization. The results were as follows: 1) A cylindrical capsule 30 mm in length, 5.7 mm in inner diameter and 0.15 mm in thickness made of natural rubber latex was newly developed to enclosure the splitter. 2) By the application of the capsule into a hole bored in a urinary calculus removed from the human bladder 55 × 35 × 33 mm in size, a division of the stone into three parts was observed in 20 minutes. 3) 10 spherical model calculi 30 mm in diameter were fragmented in 24 minutes average. 4) When the capsule was immersed in water, no change was observed on pH, in spite of the elevation of pH from 6.8 to 12.3 when the splitter was immersed directly. No leakage from the capsule was noticed in this tolerance test. © 1988, Japanese Society for Medical and Biological Engineering. All rights reserved.
  • Akihiro Kawauchi, Hiroki Watanabe, Mutsumi Uchida, Yuji Nakagawa, Akira Fujito, Koji Kitamura, Yoichiro Imaide
    Japanese journal of medical electronics and biological engineering 25 4 255 - 259 1987年 [有り][無し]
     研究論文(学術雑誌) 
    The possibility of expansive splitter used in general industry for the application to lithotripsy was evaluated experimentally. The result were as follows, 1) Expansive stress generated by expansive splitter was enough to cause all urinary stones to crack. 2) Urinary caluculus 35×30×30mm in size was fragmented within 30 minutes. 3) The spherical model caluculi 30mm in diameter were fragmented in a condition that the boring size was more than one fifth of the diameter and the boring depth was more than a half of it. The results suggested that expansive splitter could be applied clinically to fragment urinary caluculi after some improvements. © 1987, Japanese Society for Medical and Biological Engineering. All rights reserved.
  • Toshiyuki Shiga, Akihiro Kawauchi, Seiji Naitoh, Kuniaki Nakayama, Hiroshi Suzuki, Wataru Matsui, Chun Jen Lee, Kazutoshi Kawamura, Kiyoshi Hataya, Kanehiko Yoshiyama, Kazushige Arai, Kentaro Kamiya, Tetsu Kataoka, Tadashi Koike, Jun-Ichi Ishii
    Journal of The Showa Medical Association 45 2 307 - 311 1985年 [有り][無し]
     研究論文(学術雑誌) 
    Modern advancement in ultrasonographic technology permits wide implementation of ulrasonographically guided percutaneous nephrostomy as an urgent medical treatment for acute renal failure causec by various sorts of advanced malignant cancer. Recently, we had the opportunity to perform two percutaneous nephropyelostomies in patients with acute hydronephrosis and obtained satisfactory clinical results which we report hereed. We used a GC-10A linear electronic transducer for aspiration biopsy with an SAL-50A (TOSHIBA Medical Corporation). The nephropyelostomy tube, designed by us and made by HAKKO Co., was a 20 cm long 8F size silicon balloon catheter, and we used an 8.5F size PTCD set, also by HAKKO Co. Both patients had distal ureteral obstructions caused by the advanced malignant cancer and were thought to have poor surgical indication, or not at all. Case 1: A sixty-two-year-old man was admitted because of anuria and lumbago suspected to be caused by renal failure occurring after being radical operated on for gastric cancer a year and a half previous. Case 2: A fifty-two-year-old man was admitted because of anuria, pain and tenderness over the right flank probably caused by renal failure failure occurring after being radical operated on for rectum cancer eight months previous. After percutaneous nephrostomies, there were marked improvements in their clinical conditions, and no conspicuous complications. In this method, compared to those so far, 8F silicon balloon catheter is inserted into the pelvis without the use of a guide wire, and its chronic use seems to be possible. In view of the inaccuracy of other methods of assessment, we consider percutaneous nephrostomy using a balloon catheter to be the most accurate, predictive method available today. © 1985, The Showa University Society. All rights reserved.
  • Chikayoshi Suzuki, Tetsu Kataoka, Masatoshi Kawamura, Yoji Ito, Shiro Tachikawa, Shingo Takemoto, Tsutomu Takii, Chujin Lee, Akihiro Kawauchi, Kazutoshi Kawamura, Kiyoshi Hataya, Miki Shibusawa, Ken-Ichi Kobayashi, Kazushige Arai, Jun-Ichi Ishii
    Journal of The Showa Medical Association 42 4 523 - 529 1982年 [有り][無し]
     研究論文(学術雑誌) 
    Three patients suffering from chronic intermittent arteriomesentric occlusion of the duodenum were successfully treated by duodenojejunostomy with Roux-en-Y anastomosis. In the follow-up study, all patients increased in weight, were free from complaints, showed satisfactory progress and attained social readjustment. It may be emphasized that duodenojejunostomy with Roux-en-Y anastomosis is an effective operative procedure used in treating these patients. © 1982, The Showa University Society. All rights reserved.
  • Akihiro Kawauchi, Wataru Matsui, Toshiyuki Shiga, Seiji Naito, Shinya Okamoto, Yûko Nakao, Chung-Jen Lee, Kôichi Kinohira, Kazushige Arai, Akiyoshi Ando, Kazuo Koizumi, Tadashi Sato, Tetsu Kataoka, Tadashi Koike, Jun-Ichi Ishii
    Journal of The Showa Medical Association 42 6 819 - 824 1982年 [有り][無し]
     研究論文(学術雑誌) 
    Recently, ultrasonic diagnostic equipment has been so widely used that early diagnosis is much more frequent, especially in cases of digestive disorders. However, it is still difficult to diagnose pancreatic lesions or submucosal lesions of the upper digestive tract by scanning from the abdominal wall with electric linear scanners, because their potential for tissue characta-rization is still insufficient. Thus, ultrasonic endoscopy for direct scanning from the inside of the upper digestive tract has been recently developed (Olympus Co. and, Aloka Co.). The authors had the opportunity of using this new equipment and to evaluate its efficiency in the diagnosis of three clinical conditions pancreas cancer, pancreas cyst and duodenal leiomyoma. Some difficulties arose in obtaining clear pictures, because the tip of the gastroscope, where the 5.0 MHz ultrasonic probe was fixed, was too long to be adequately controlled. If this device is improved from this standpoint, the scanning method would be useful in the diagnosis of epigastric diseases. © 1982, The Showa University Society. All rights reserved.

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    小児におけるロボット支援手術の保険適応がなされない本邦において、気膀胱下Cohen法は、VURに対する低侵襲手術として、認知され、徐々に広まりを見せている。本学会学術集会でも、その初期経験が多数報告されている。一方で技術的な問題点や、合併症等も報告され、手術としてTrialの段階から標準化を目指すPhaseに入ったといえる。本稿では、一般的な他の腹腔鏡手術、開腹手術でのCohen法を行う場合と異なる操作に焦点をあて、気膀胱逆流防止術(Cohen法)を行う上での'コツ'や注意点を解説する。【ポート造設】(1)経腹膜留置を避けるための細心の注意を払う。(2)吊り糸用の穿刺針の工夫をする。(3)操作を膀胱壁近くで行い、空間失調を防ぐ。【尿管の剥離】(1)尿管の牽引を早期から助手に牽引してもらう。(2)12時方向から剥離を行う。【粘膜下トンネル】(1)把持側の鉗子で強く牽引しない。(2)トンネルを作成する側の鉗子は、開閉と鉗子方向の運動だけで操作する。(3)視野確保をカメラワークでサポートする。【尿管膀胱吻合】(1)Anchor sutureで直感的に運針すると、難しい症例がある。(2)特に左尿管尾側で操作時間が長い傾向にあり、運針前に膀胱、尿管どちらから運針するか慎重に検討する。(著者抄録)
  • 胚細胞腫瘍に類似しEP療法が奏功した原発不明癌の1例
    小崎 成昭, 富田 圭司, 鈴木 友理, 森 友莉, 吉田 啓介, 沖中 勇輝, 村井 亮介, 小林 憲市, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 66 (3) 98 -99 2020年03月 [無し][無し]
  • 内科的治療後、単孔式腹腔鏡下膀胱部分切除術を行った炎症性筋線維芽細胞腫(IMT)の1例
    田口 俊亮, 沖中 勇輝, 森 和徳, 猪飼 信康, 森谷 鈴子, 森 友莉, 小崎 成昭, 鈴木 友理, 小林 憲市, 村井 亮介, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 66 (2) 61 -61 2020年02月 [無し][無し]
  • 代謝型グルタミン酸受容体による射精調節
    馬杉 美和子, 富田 圭司, 吉田 哲也, 影山 進, 河内 明宏 日本性機能学会雑誌 34 (3) 243 -243 2019年12月 [無し][無し]
  • 当院における尿膜管膿瘍に対する単孔式腹腔鏡下尿膜管摘除術の経験
    草場 拓人, 永澤 誠之, 富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 24 (7) MO229 -5 2019年12月 [無し][無し]
  • 低リスクNMIBCに対するTHP短時間単回膀胱内注入療法 MMCとの比較
    影山 進, 窪田 成寿, 前田 航規, 長船 崇, 西川 全海, 瀧本 啓太, 坂野 祐司, 曽我 弘樹, 金 哲將, 吉田 哲也, 成田 充弘, 河内 明宏 日本癌治療学会学術集会抄録集 57回 O11 -5 2019年10月 [無し][無し]
  • 遺伝子発現データ解析に基づく腎細胞癌のバイオマーカーの同定とリスクモデルの構築
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  • 進行性腎癌に対するニボルマブの治療効果予測因子の検討
    吉田 哲也, 富田 圭司, 村井 亮介, 水流 輝彦, 影山 進, 成田 充弘, 河内 明宏 日本癌治療学会学術集会抄録集 57回 P97 -6 2019年10月 [無し][無し]
  • 当院における転移性前立腺癌に対する局所治療の治療効果
    成田 充弘, 和田 晃典, 永澤 誠之, 沖中 勇輝, 水流 輝彦, 吉田 哲也, 影山 進, 河内 明宏 日本癌治療学会学術集会抄録集 57回 P108 -1 2019年10月 [無し][無し]
  • 当院における間質性膀胱炎に対する膀胱水圧拡張術の評価
    水流 輝彦, 森 友莉, 窪田 成寿, 和田 晃典, 富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本排尿機能学会誌 30 (1) 327 -327 2019年09月 [無し][無し]
  • GGCTの発現低下はAMPK-FOXO3a-p21経路を介してがん細胞の増殖を抑制する(Depletion of gammaglutamylcyclotransferase(GGCT) inhibits cancer cell growth via AMPK-FOXO3a-p21 axis)
    谷口 恵香, 飯居 宏美, 影山 進, 高木 寛子, 茂山 千愛美, 安藤 翔太, 芦原 英司, 茶野 徳宏, 河内 明宏, 中田 晋 日本癌学会総会記事 78回 P -1223 2019年09月 [無し][無し]
  • 膵臓癌と膀胱癌における新規PDK4阻害剤による浸潤転移の抑制(Suppression of invasion and metastasis by a novel PDK4 inhibitor in pancreatic and bladder cancers)
    金 哲將, 寺戸 勅雄, 旦部 幸博, 河内 明宏, 向所 賢一, 杉原 洋行, 井上 寛一 日本癌学会総会記事 78回 P -2049 2019年09月 [無し][無し]
  • 水流 輝彦, 沖中 勇輝, 窪田 成寿, 村井 亮介, 富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本老年泌尿器科学会誌 32 (1) 184 -184 2019年05月 [無し][無し]
  • 腎門部に位置するcT1、cN0、cM0腎腫瘍の患者を対象にda Vinciサージカルシステムを用いた腎部分切除術の有効性を評価する多施設共同非盲検単群臨床研究
    藤澤 正人, 白木 良一, 田邉 一成, 江藤 正俊, 武中 篤, 川喜田 睦司, 原 勲, 浮村 理, 伊夫貴 直和, 那須 保友, 松原 昭郎, 河合 憲康, 河内 明宏, 近藤 恒徳, 荒井 陽一, 大山 力, 堀江 重郎, 新保 正貴, 後藤 百万, 金山 博臣, 小糸 悠也, ROBOHIT研究グループ 日本泌尿器科学会総会 107回 PP2 -157 2019年04月 [無し][無し]
  • In vivo phage display法を用いた前立腺癌特異的組織標的ペプチドによる新規治療法の開発
    和田 晃典, 小島 秀人, 寺島 智也, 影山 進, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 107回 PP3 -067 2019年04月 [無し][無し]
  • Gamma-glutamylcyclotransferase(GGCT)欠乏で誘導されるp21発現上昇は乳癌細胞においてProhibitin-2を介して調節される
    谷口 恵香, 影山 進, 高木 寛子, 飯居 宏美, 芦原 英司, 茶野 徳宏, 河内 明宏, 中田 晋 日本薬学会年会要旨集 139年会 (3) 77 -77 2019年03月 [無し][無し]
  • 【よくある疾患の診かた-他科からの助言-】 泌尿器科 尿失禁・夜尿
    河内 明宏, 上仁 数義, 小林 憲市 小児科臨床 71 (増刊) 1989 -1994 2018年10月 [無し][無し]
  • 乳癌細胞においてGGCT欠乏で誘導されるp21はProhibitin-2を介して調節される(Prohibitin-2 regulates p21 expression induced by depleting gamma-glutamylcyclotransferase in breast cancer cells)
    谷口 恵香, 松村 健吾, 影山 進, 飯居 宏美, 芦原 英司, 茶野 徳宏, 河内 明宏, 吉貴 達寛, 中田 晋 日本癌学会総会記事 77回 1854 -1854 2018年09月 [無し][無し]
  • In vivo phage biopanningによる前立腺癌特異的組織標的ペプチドの開発(Identification of novel cell specific DDS peptides for prostate cancer by in vivo phage biopanning)
    和田 晃典, 小島 秀人, 寺島 智也, 影山 進, 河内 明宏 日本癌学会総会記事 77回 614 -614 2018年09月 [無し][無し]
  • 小児下部尿路機能障害 夜尿症
    河内 明宏, 上仁 数義, 小林 憲市 日本排尿機能学会誌 29 (1) 159 -159 2018年09月 [無し][無し]
  • 女性骨盤臓器脱患者の下部尿路症状に対する腹腔鏡下仙骨腟固定術(LSC)・TVMの評価
    水流 輝彦, 沖中 勇輝, 富田 圭司, 村井 亮介, 吉田 哲也, 河内 明宏 日本排尿機能学会誌 29 (1) 288 -288 2018年09月 [無し][無し]
  • 自排尿が可能な小児二分脊椎患者に対するuroflowmetryの有用性の評価
    窪田 成寿, 小林 憲市, 水流 輝彦, 上仁 数義, 河内 明宏 日本排尿機能学会誌 29 (1) 295 -295 2018年09月 [無し][無し]
  • PKD医学の最先端 CRISPR/Cas9を用いたADPKDモデルカニクイザルの作出と解析
    依馬 正次, 築山 智之, 小林 憲市, 和泉 博之, 河内 明宏 日本腎臓学会誌 60 (6) 860 -860 2018年08月 [無し][無し]
  • 両側膀胱尿管逆流症の術後に薬剤性腎障害による急性腎不全を呈した1例
    佐藤 亘, 小林 憲市, 小田 和哉, 中川 翔太, 沖中 勇輝, 伊狩 亮, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 64 (7) 313 -313 2018年07月 [無し][無し]
  • 当院における進行性腎癌に対するニボルマブ治療の臨床的検討
    吉田 哲也, 沖中 勇輝, 富田 圭司, 村井 亮介, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 腎癌研究会会報 (48) 44 -44 2018年07月 [無し][無し]
  • 進行性腎癌に対する1st-line治療の臨床的検討 スニチニブとパゾパニブの比較
    吉田 哲也, 中川 翔太, 沖中 勇輝, 富田 圭司, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 腎癌研究会会報 (48) 95 -95 2018年07月 [無し][無し]
  • 深部子宮内膜症手術と他科との連携 膀胱・尿管子宮内膜症における婦人科・泌尿器科の連携
    河内 明宏 日本エンドメトリオーシス学会会誌 39 70 -70 2018年07月 [無し][無し]
  • 進化する医療:安全な小児腹腔鏡手術のために 安全な小児腹腔鏡手術を行うために
    河内 明宏 日本小児泌尿器科学会雑誌 27 (2) 173 -173 2018年06月 [無し][無し]
  • 小林 憲市, 上仁 数義, 河内 明宏 日本小児泌尿器科学会雑誌 27 (2) 193 -193 2018年06月 [無し][無し]
  • 小林 憲市, 中川 翔太, 佐藤 亘, 山崎 友莉, 上仁 数義, 河内 明宏 日本小児泌尿器科学会雑誌 27 (2) 204 -204 2018年06月 [無し][無し]
  • 中川 翔太, 上仁 数義, 山崎 友莉, 佐藤 亘, 小林 憲市, 河内 明宏, 松井 克之, 井藤 隆太 日本小児泌尿器科学会雑誌 27 (2) 210 -210 2018年06月 [無し][無し]
  • 上仁 数義, 山崎 友莉, 佐藤 亘, 中川 翔太, 小林 憲市, 河内 明宏 日本小児泌尿器科学会雑誌 27 (2) 220 -220 2018年06月 [無し][無し]
  • 佐藤 亘, 小林 憲市, 山崎 友莉, 中川 翔太, 上仁 数義, 河内 明宏 日本小児泌尿器科学会雑誌 27 (2) 284 -284 2018年06月 [無し][無し]
  • 山崎 友莉, 上仁 数義, 九嶋 亮治, 大竹 真, 小林 憲市, 中川 翔太, 佐藤 亘, 河内 明宏 日本小児泌尿器科学会雑誌 27 (2) 302 -302 2018年06月 [無し][無し]
  • 泌尿器科入院患者における栄養状態の評価について
    西田 香, 栗原 美香, 中西 直子, 馬場 重樹, 佐々木 雅也, 河内 明宏 栄養 3 (2) 140 -140 2018年06月 [無し][無し]
  • ドーパミン産生褐色細胞腫の1例
    沖中 勇輝, 佐藤 亘, 中川 翔太, 伊狩 亮, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 64 (6) 287 -287 2018年06月 [無し][無し]
  • 診断に難渋した両側尿管狭窄の1例
    城 文泰, 牛田 博, 沖中 勇輝, 富田 圭司, 河内 明宏 泌尿器科紀要 64 (6) 291 -291 2018年06月 [無し][無し]
  • 薬剤性間質性腎炎が疑われたが腎生検を行わずに診断的治療を行った1例
    一岡 聡子, 奥田 雄介, 坂井 智行, 澤井 俊宏, 小林 憲市, 河内 明宏 日本小児科学会雑誌 122 (6) 1096 -1096 2018年06月 [無し][無し]
  • 原発性アルドステロン症とクッシング症候群合併例に腹腔鏡下副腎部分切除術を施行した1例
    金 哲將, 窪田 成寿, 福山 佳代, 大村 寧, 花田 英紀, 河内 明宏 泌尿器科紀要 64 (6) 265 -269 2018年06月 [無し][無し]
     
    症例は65歳男性で、糖尿病治療中、経口血糖降下薬多剤を投与してもHbA1c 10%以上が続くため当院入院となった。CT検査の結果、直径約25mmの辺縁明瞭で内部は不均一な濃度の左副腎腫瘍を認めた。右副腎に関しては異常を認めなかった。その他の検査結果と合わせACTH非依存性副腎性クッシング症候群(CS)に矛盾しないが、皮膚の菲薄化以外は特徴的な身体所見に乏しい所見であり、つぎに、原発性アルドステロン症(PA)の合併の可能性が考えられた。確定診断のために副腎静脈サンプリングを施行したところ、両側副腎からのアルドステロン過剰産生によるPAと副腎性CS合併と考えられた。左副腎腫瘍は直径25mmで悪性腫瘍の可能性は低く、左副腎頭側に存在することより副腎部分切除術施行に適した腫瘍であることに加え、アルドステロン分泌は右副腎が優位なため将来の右副腎全摘除術施行の可能性も考慮し左副腎の非腫瘍部を残すことが必要であると考え、左副腎腫瘍を含めた腹腔鏡下左副腎部分切除術を施行した。摘除した組織の病理診断の結果、特発性アルドステロン症と左副腎コルチゾール産生腺腫の合併と診断した。術後経過は順調で、術後年1回CTにより副腎の画像評価を行っているが、術後2年目の時点で著変を認めていない。
  • 当院における転移性腎細胞癌に対するニボルマブの初期使用経験
    佐藤 亘, 小田 和哉, 中川 翔太, 沖中 勇輝, 伊狩 亮, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 64 (5) 246 -246 2018年05月 [無し][無し]
  • 【プライマリ・ケアでおさえておきたい 重要薬・頻用薬】泌尿・生殖器薬 排尿障害(下部尿路症状)治療薬
    河内 明宏 Medicina 55 (4) 438 -441 2018年04月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏 臨床泌尿器科 72 (4) 119 -127 2018年04月 [無し][無し]
     
    <文献概要>Point ●肥満体型の患者,著明な炎症,複雑な解剖が予想される場合は,多孔式のほうが望ましい.●ポートの出し入れを容易にし,かつ鉗子の干渉を防ぐために,皮下組織および筋膜を皮膚切開よりも広く十分に剥離しておく.●術創は臍と2〜3mmの左手ポートのみであり,美容的に優れている.
  • 村井 亮介, 影山 進, 伊藤 靖, 石垣 宏仁, 寺本 和雄, 吉田 哲也, 富田 圭司, 小林 憲市, 和田 晃典, 永澤 誠之, 窪田 成寿, 小笠原 一誠, 河内 明宏 泌尿器外科 31 (4) 403 -404 2018年04月 [無し][無し]
  • 【前立腺肥大症に対する新規技術】 腹腔鏡下・ロボット支援下被膜下前立腺腺腫核出術
    村井 亮介, 吉田 哲也, 河内 明宏 Prostate Journal 5 (1) 69 -73 2018年04月 [無し][無し]
     
    大きなサイズの前立腺肥大症に対する腹腔鏡下およびロボット支援下被膜下前立腺腺腫核出術は本邦未承認であるが、欧米から報告されている。開腹術と比較すると出血量が少なく尿道カテーテル留置期間や在院日数が短縮され、治療効果や合併症発現率は同等であり、安全かつ有効な治療法であると考えられる。しかしながら、他の術式との比較における安全性や有効性の根拠は十分ではなく、今後のエビデンス集積が望まれる。(著者抄録)
  • 小林 憲市, 上仁 数義, 河内 明宏 泌尿器外科 31 (特別号) 296 -303 2018年04月 [無し][無し]
  • 下部尿路症状を有する小児患者は、病院と自宅で異なるウロフローを呈する
    上仁 数義, 小林 憲市, 河内 明宏 日本泌尿器科学会総会 106回 OP -071 2018年04月 [無し][無し]
  • 60歳以上の前立腺癌患者における血中脂質値と病理学的因子の検討
    沖中 勇輝, 成田 充弘, 佐藤 亘, 中川 翔太, 伊狩 亮, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏 日本泌尿器科学会総会 106回 OP -302 2018年04月 [無し][無し]
  • デュタステリド休薬後の排尿状態の評価
    水流 輝彦, 佐藤 亘, 中川 翔太, 沖中 勇輝, 伊狩 亮, 富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 106回 OP -497 2018年04月 [無し][無し]
  • GGCT(γ-グルタミルシクロトランスフェラーゼ)阻害を作用機序とした新規抗癌剤の開発
    影山 進, 窪田 成寿, 村井 亮介, 吉矢 拓, 飯居 宏美, 中田 晋, 吉貴 達寛, 河内 明宏 日本泌尿器科学会総会 106回 PP1 -021 2018年04月 [無し][無し]
  • 正所性膀胱癌モデルラットを用いたBCG膀胱注入療法による免疫抑制性細胞の検討
    村井 亮介, 影山 進, 伊藤 靖, 石垣 宏仁, 寺本 和雄, 吉田 哲也, 富田 圭司, 小林 憲市, 和田 晃典, 永澤 誠之, 窪田 成寿, 小笠原 一誠, 河内 明宏 日本泌尿器科学会総会 106回 PP1 -029 2018年04月 [無し][無し]
  • ロボット支援腹腔鏡下前立腺全摘除術における拡大リンパ節郭清術についての検討
    成田 充弘, 永澤 誠之, 沖中 勇輝, 影山 進, 吉田 哲也, 水流 輝彦, 冨田 圭司, 伊狩 亮, 和田 晃典, 中川 翔太, 佐藤 亘, 河内 明宏 日本泌尿器科学会総会 106回 PP2 -135 2018年04月 [無し][無し]
  • ソフト凝固システムを併用し無阻血・無縫合で施行したロボット支援腹腔鏡下腎部分切除術の治療成績
    富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 106回 PP3 -399 2018年04月 [無し][無し]
  • Gamma-glutamylcyclotransferase(GGCT)の発現低下はがん細胞にオートファジーを介して細胞老化を誘導する
    谷口 恵香, 松村 健吾, 飯居 宏美, 影山 進, 芦原 英司, 河内 明宏, 吉貴 達寛, 中田 晋 日本薬学会年会要旨集 138年会 (3) 74 -74 2018年03月 [無し][無し]
  • 【この1冊で安心! 泌尿器科当直医マニュアル<外来編>】 陰茎絞扼症・嵌頓包茎
    小林 憲市, 河内 明宏 臨床泌尿器科 72 (3) 239 -247 2018年03月 [無し][無し]
     
    <ポイント>・硬性絞扼物は除去は難しいが,重症化しにくい.・軟性絞扼物は除去は容易であるが,重篤な合併症を来しやすい.・硬性絞扼物の除去に関しては,絞扼物,絞扼具合に応じて最も適した方法を選択する必要がある.・嵌頓包茎の用手整復は事前の準備を整えて行うことが重要である.(著者抄録)
  • 滋賀県の慢性透析療法の現況(2015年12月31日現在)
    金崎 雅美, 荒木 信一, 河内 明宏, 江口 豊, 秋岡 清一, 門 浩志, 磯野 元秀, 前田 咲弥子, 新井 豊, 西尾 利樹, 有村 哲朗, 西村 正孝, 一色 啓二, 谷口 正展 滋賀医学 40 9 -13 2018年03月 [無し][無し]
     
    2015年12月31日現在の滋賀県における慢性透析患者数は3122人、慢性透析導入患者数は415人で、人口100万人当たりの慢性透析患者数は全国に比べて低い。一方、慢性透析の治療形態のうち腹膜透析、在宅血液透析、夜間透析の比率はいずれも全国平均に比べて高く、患者の多様な生活形態や希望に沿うよう努力していると言える。2001年末から2015年末までの慢性透析患者数の推移、慢性透析導入原疾患や年齢の推移、粗死亡率と主要死因の推移などを表に示し、滋賀県の2015年末の現状を述べた。
  • 膀胱のリンパ腫様型/形質細胞様型尿路上皮癌の1例
    中川 翔太, 窪田 成寿, 西田 将成, 沖中 勇輝, 富田 圭司, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 64 (3) 137 -137 2018年03月 [無し][無し]
  • 沖中 勇輝, 成田 充弘, 永澤 誠之, 和田 晃典, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏 日本老年泌尿器科学会誌 30 79 -79 2018年03月 [無し][無し]
  • Gamma-glutamylcyclotransferase(GGCT)の発現低下はがん細胞にオートファジーを介して細胞老化を誘導する
    谷口 恵香, 松村 健吾, 飯居 宏美, 影山 進, 芦原 英司, 河内 明宏, 吉貴 達寛, 中田 晋 日本薬学会年会要旨集 138年会 (3) 74 -74 2018年03月 [無し][無し]
  • 泌尿器科入院患者における栄養状態の評価と病棟担当栄養士の関わり
    西村 さゆみ, 栗原 美香, 佐々木 雅也, 河内 明宏 日本病態栄養学会誌 21 (Suppl.) S -149 2018年01月 [無し][無し]
  • 【改訂 男性下部尿路症状・前立腺肥大症診療ガイドライン】 男性下部尿路症状・前立腺肥大症の行動療法
    河内 明宏 排尿障害プラクティス 25 (2) 139 -145 2017年12月 [無し][無し]
     
    男性下部尿路症状、前立腺肥大症に対する行動療法において有効性があり推奨されるものは、症状が軽度で合併症がない患者に対する経過観察、肥満者に対する食事制限などによる体重減少、総合的な行動療法指導、過活動膀胱に対する骨盤底筋体操、膀胱訓練、前立腺全摘除術後の尿失禁に対する骨盤底筋体操などである。(著者抄録)
  • ソフト凝固システムを併用し無阻血・無縫合で施行したロボット支援腹腔鏡下腎部分切除術の治療成績
    富田 圭司, 吉田 哲也, 永澤 誠之, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 22 (7) SF059 -04 2017年12月 [無し][無し]
  • 当院におけるロボット支援腹腔鏡下前立腺全摘除術の治療成績とlearning curveの検討
    永澤 誠之, 富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 22 (7) EP195 -04 2017年12月 [無し][無し]
  • CRISPR/Cas9を用いた疾患モデルカニクイザルの作出
    築山 智之, 小林 憲市, 岩谷 千鶴, 土屋 英明, 清田 弥寿成, 松下 淳, 北嶋 郁, 河本 育士, 中川 孝博, 福田 浩司, 岩切 哲平, 和泉 博之, 板垣 伊織, 中村 紳一朗, 河内 明宏, 依馬 正次 生命科学系学会合同年次大会 2017年度 [3P -0848] 2017年12月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏 Japanese Journal of Endourology 30 (3) 133 -133 2017年11月 [無し][無し]
  • 吉田 哲也, 沖中 勇輝, 伊狩 亮, 富田 圭司, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 30 (3) 137 -137 2017年11月 [無し][無し]
  • 小林 憲市, 上仁 数義, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 30 (3) 142 -142 2017年11月 [無し][無し]
  • ロボット支援前立腺全摘除術における断端陽性率、尿禁制改善を目指した術式の工夫
    成田 充弘, 影山 進, 吉田 哲也, 水流 輝彦, 冨田 圭司, 伊狩 亮, 中川 翔太, 佐藤 亘, 小田 和哉, 河内 明宏 Japanese Journal of Endourology 30 (3) 159 -159 2017年11月 [無し][無し]
  • 花田 英紀, 河内 明宏, 成田 充弘, 上仁 数義, 影山 進, 吉田 哲也, 水流 輝彦, 富田 圭司, 伊狩 亮, 沖中 勇輝 Japanese Journal of Endourology 30 (3) 232 -232 2017年11月 [無し][無し]
  • 当院における精索静脈瘤に対する腹腔鏡下高位結紮術の治療成績
    富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本生殖医学会雑誌 62 (4) 444 -444 2017年10月 [無し][無し]
  • 【新腎・泌尿器癌(下)-基礎・臨床研究の進歩-】 膀胱癌 膀胱癌の治療 膀胱内注入療法 抗癌剤
    影山 進, 窪田 成寿, 河内 明宏 日本臨床 75 (増刊7 新腎・泌尿器癌(下)) 263 -267 2017年10月 [無し][無し]
  • 【新腎・泌尿器癌(下)-基礎・臨床研究の進歩-】 精巣癌 精巣癌の特徴 精巣癌の発症・進展メカニズム
    富田 圭司, 影山 進, 河内 明宏 日本臨床 75 (増刊7 新腎・泌尿器癌(下)) 366 -369 2017年10月 [無し][無し]
  • 低リスク筋層非浸潤性膀胱癌に対する術直後ピラルビシン短時間膀注療法
    影山 進, 窪田 成寿, 村井 亮介, 沖中 勇輝, 小林 憲市, 富田 圭司, 水流 輝彦, 吉田 哲也, 上仁 数義, 成田 充弘, 藤原 遼, 伊狩 亮, 佐野 太一, 坂野 祐司, 河内 明宏 日本癌治療学会学術集会抄録集 55回 P31 -2 2017年10月 [無し][無し]
  • 腎細胞がん患者におけるパゾパニブの血中濃度に基づく臨床効果・副作用の評価
    野田 哲史, 平 大樹, 吉田 哲也, 冨田 圭司, 水流 輝彦, 影山 進, 河内 明宏, 森田 真也, 寺田 智祐 日本癌治療学会学術集会抄録集 55回 P37 -3 2017年10月 [無し][無し]
  • ロボット支援前立腺全摘除術における外科断端陰性、尿禁制温存を目指した術式の工夫
    成田 充弘, 影山 進, 吉田 哲也, 永澤 誠之, 河内 明宏 日本癌治療学会学術集会抄録集 55回 P95 -5 2017年10月 [無し][無し]
  • Cyclin D1bによるアポトーシス誘導と癌幹細胞特性の抑制を介した、ヒト膀胱癌細胞に対する抗腫瘍活性の検討
    金 哲將, 寺戸 勅雄, 旦部 幸博, 向所 賢一, 杉原 洋行, 河内 明宏, 井上 寛一 日本癌学会総会記事 76回 P -1084 2017年09月 [無し][無し]
  • γ-グルタミルシクロトランスフェラーゼ(GGCT)の発現低下はオートファジーを介して細胞老化を誘導する
    谷口 恵香, 中田 晋, 松村 健吾, 飯居 宏美, 影山 進, 河内 明宏, 吉貴 達寛 日本癌学会総会記事 76回 P -3074 2017年09月 [無し][無し]
  • P-Flowdiaryは、下部尿路症状を有する小児患者の評価に有用である
    上仁 数義, 小林 憲市, 水流 輝彦, 河内 明宏 日本排尿機能学会誌 28 (1) 190 -190 2017年09月 [無し][無し]
  • 病院と自宅における尿流測定の評価 P-Flowdiaryを用いて
    水流 輝彦, 佐藤 亘, 中川 翔太, 小林 憲市, 上仁 数義, 河内 明宏 日本排尿機能学会誌 28 (1) 243 -243 2017年09月 [無し][無し]
  • 当院におけるホルミウム・レーザー核出術(HoLEP)の治療成績
    中川 翔太, 水流 輝彦, 花田 英紀, 佐藤 亘, 沖中 勇輝, 伊狩 亮, 富田 圭司, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本排尿機能学会誌 28 (1) 287 -287 2017年09月 [無し][無し]
  • hCG補充中止後も血清テストステロン値が正常を維持した先天性低ゴナドトロピン性性腺機能低下症の1例
    中川 翔太, 富田 圭司, 西田 将成, 沖中 勇輝, 窪田 成寿, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 63 (8) 343 -343 2017年08月 [無し][無し]
  • 河内 明宏, 小林 憲市, 上仁 数義 泌尿器外科 30 (7) 1123 -1127 2017年07月 [無し][無し]
     
    腹腔鏡下腎盂形成術は2013年より泌尿器腹腔鏡技術認定制度のビデオ審査対象術式として認められた。本術式はビデオ審査対象術式のうちの唯一の形成術であり、縫合操作が含まれるため、技術的に難度が高い。本術式のポイントにつき概説する。(著者抄録)
  • Nd-YAGレーザーを用いた陰茎亀頭部血管腫の治療経験
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  • 未分化癌と考えられた巨大腎盂原発腫瘍の1剖検例
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  • カバジタキセルの長期投与が可能であった去勢抵抗性前立腺癌の1例
    曽我 弘樹, 和田 晃典, 河内 明宏 泌尿器科紀要 63 (7) 292 -292 2017年07月 [無し][無し]
  • 進行性腎癌に対する1st-line治療の臨床的検討 スニチニブとパゾパニブの比較
    吉田 哲也, 中川 翔太, 沖中 勇輝, 富田 圭司, 水流 輝彦, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 腎癌研究会会報 (47) 35 -35 2017年07月 [無し][無し]
  • 転移性腎癌に対するパゾパニブ治療の臨床的検討
    吉田 哲也, 西田 将成, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏, 野田 哲史, 寺田 智祐 腎癌研究会会報 (47) 104 -104 2017年07月 [無し][無し]
  • P-Flowdiaryは、新しい携帯式尿流量計で下部尿路症状を有する小児患者の評価に有用である
    上仁 数義, 小林 憲市, 河内 明宏 日本夜尿症学会学術集会プログラム・抄録集 28回 32 -32 2017年07月 [無し][無し]
  • 上仁 数義, 中川 翔太, 小林 憲市, 河内 明宏 日本小児泌尿器科学会雑誌 26 (2) 244 -244 2017年06月 [無し][無し]
  • 小林 憲市, 富田 圭司, 上仁 数義, 河内 明宏 日本小児泌尿器科学会雑誌 26 (2) 313 -313 2017年06月 [無し][無し]
  • 澤井 ちひろ, 西倉 紀子, 阪上 由子, 上仁 数義, 小林 憲市, 河内 明宏 夜尿症研究 22 43 -48 2017年06月 [無し][無し]
     
    目的:神経発達障害児の尿失禁の治療予後と心理社会的要因を検討する。方法:対象は器質的疾患を伴わない尿失禁にて、小児科発達外来と泌尿器科を併診する23例である。尿失禁のサブタイプを単一症候性夜尿、昼間尿失禁のみ、非単一症候性夜尿で昼間尿失禁を伴う併存群の3つに分類した。発達診断は米国精神医学会診断基準DSM-5に基づいて行った。行動療法と薬物療法を施行後、各群の予後と心理社会的影響を検討した。結果:初診時年齢8歳(中央値)、男児16例、女児7例であった。サブタイプは単一症候性夜尿群8例、昼間尿失禁群5例、併存群10例で、発達診断は注意欠如・多動症13例、自閉症スペクトラム障害9例、学習障害6例(重複あり)、知的発達は重度精神遅滞2例、境界知能7例、平均域以上11例、不明3例であった。単一症候性夜尿群は生活指導、アラーム、抗コリン薬のいずれかの単独療法にて9割が改善した。昼間尿失禁群の半数は時間排尿指導にて改善したが、自閉症児は難治であった。併存群は抗利尿ホルモン薬、抗コリン薬、アラームの併用療法を要し、夜尿の半数は改善したが、昼間尿失禁は残存した。結論:神経発達障害児の夜尿は標準治療で大幅に改善した。一方、昼間尿失禁は難治であった。尿失禁の予後と関連して、不適切な養育や学力不振などの心理社会的要因を認めており、発達特性への配慮や環境調整が必要であると考えられた。(著者抄録)
  • 夜尿症
    河内 明宏, 上仁 数義, 小林 憲市 日本睡眠学会定期学術集会プログラム・抄録集 42回 151 -151 2017年06月 [無し][無し]
  • Pulmonary tumor thrombotic microangiopathy(PTTM)によって呼吸不全を来たした前立腺癌の1例
    西田 将成, 永澤 誠之, 城 文泰, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 63 (5) 219 -219 2017年05月 [無し][無し]
  • 太田 裕之, 園田 寛道, 清水 智治, 水流 輝彦, 吉田 哲也, 西田 将成, 成田 充弘, 河内 明宏, 植木 智之, 三宅 亨, 生田 大二, 目片 英治, 遠藤 善裕, 谷 眞至 滋賀医科大学雑誌 30 (1) 76 -80 2017年05月 [無し][無し]
     
    我々は直腸脱を合併した子宮摘出後の腟断端脱、直腸瘤に対して腹腔鏡下に一期的修復術を施行した1例を経験したので文献的考察を加えて報告する。症例は75歳3回経産婦。会陰部の臓器脱出感を主訴に当院泌尿器科を受診。子宮脱に対して腟式子宮全摘術の既往歴がある。身体所見より膀胱瘤(Stage I)腟断端脱(Stage III)、直腸瘤(Stage II)および直腸脱と診断した。一期的に修復術を行う方針のもと2015年に腹腔鏡下に仙骨腟固定術および直腸固定術を施行した。手順として、まず腟断端周囲を充分に剥離してY字型メッシュを腟に固定しておいた。次いで直腸周囲を充分に剥離した後に仙骨前面に固定した正方形メッシュを直腸後壁に巻き付けて縫合固定した。最後に腟断端をY字型メッシュのアームで牽引して仙骨岬角右側に固定した。手術時間は8時間14分で、出血量は200gであった。術後経過は良好で術後6日に退院した。術後1年半を経過した時点では再発徴候や排泄障害は認めていない。直腸脱を合併した腟断端脱、直腸瘤に対して腹腔鏡下に仙骨腟固定術および直腸固定術を行うことは低侵襲で一期的に修復できる有用な術式であると考えられる。(著者抄録)
  • Keiji Tomita, Eiki Hanada, Susumu Kageyama, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 197 (4) E1057 -E1058 2017年04月 [無し][無し]
  • 河内 明宏, 上仁 数義, 小林 憲市 泌尿器外科 30 (特別号) 328 -336 2017年04月 [無し][無し]
     
    夜間眠ったままで排尿することを、夜尿(おねしょ)といい、排尿と睡眠の機構が大人型になる5歳以降で、1ヵ月に1回以上の夜尿が3ヵ月以上続くものを病的と考え夜尿症と呼ぶ。診断においては、基礎疾患の除外や様々な患者背景を知る上でも問診が重要である。検査としては尿検査を全症例行い、基礎疾患を除外する。残尿測定、腎超音波検査といった泌尿器科学的疾患鑑別のための検査、排尿日誌などは治療効果のない症例など症例を選択して行う。治療としてはまず生活指導・行動療法を行う。夜尿日誌をつける、夜間の水分摂取制限、寝る前の完全排尿などで、数週間以上行う。生活指導・行動療法で改善しない場合は、夜尿アラーム療法と抗利尿ホルモンのどちらかを行う。それで無効の場合は他方の治療を行うか、両者を併用する。(著者抄録)
  • 泌尿器科領域におけるトラブルシューティング(第79回) 腹腔鏡下膀胱内手術におけるトラブルシューティング
    河内 明宏 泌尿器外科 30 (4) 419 -420 2017年04月 [無し][無し]
  • 村井 亮介, 影山 進, 仲山 美沙子, 石垣 宏仁, 寺本 和雄, 伊藤 靖, 富田 圭司, 小林 憲市, 和田 晃典, 永澤 誠之, 小笠原 一誠, 河内 明宏 泌尿器外科 30 (4) 437 -438 2017年04月 [無し][無し]
  • 【まるごと 泌尿器科の術式別術前・術後管理】 膀胱surgery 術前術後管理 膀胱尿管逆流防止術の術前・術後管理
    河内 明宏 Uro-Lo: 泌尿器Care & Cure 22 (2) 166 -168 2017年04月 [無し][無し]
  • 当科における単孔式腹腔鏡下腎盂形成術の経験 ロボット支援下腹腔鏡下腎盂形成術との比較
    小林 憲市, 上仁 数義, 中川 翔太, 西田 将成, 沖中 勇輝, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 105回 UP10 -1 2017年04月 [無し][無し]
  • 精索静脈瘤に対する単孔式腹腔鏡下高位結紮術における脈管識別のための工夫
    富田 圭司, 中川 翔太, 西田 将成, 沖中 勇輝, 窪田 成寿, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 105回 AVP1 -04 2017年04月 [無し][無し]
  • ソフト凝固併用腹腔鏡下腎部分切除術
    成田 充弘, 吉田 哲也, 花田 英紀, 影山 進, 上仁 数義, 水流 輝彦, 小林 憲市, 富田 圭司, 長谷 行洋, 馬塲 雅人, 鄭 裕午, 河内 明宏 日本泌尿器科学会総会 105回 OP53 -6 2017年04月 [無し][無し]
  • 局所浸潤性腎盂尿管癌患者における周術期栄養関連指標と術後転帰の検討
    沖中 勇輝, 影山 進, 中川 翔太, 西田 将成, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 105回 OP55 -7 2017年04月 [無し][無し]
  • 新規癌増殖因子GGCT/C7orf24を標的とした抗がん剤の開発 小規模プロテオーム解析からの挑戦
    影山 進, 花田 英紀, 窪田 成寿, 富田 圭司, 村井 亮介, 小林 憲市, 飯居 宏美, 中田 晋, 吉矢 拓, 礒野 高敬, 湯浅 健, 吉貴 達寛, 河内 明宏 日本泌尿器科学会総会 105回 OP63 -1 2017年04月 [無し][無し]
  • G1/S抑制とアポトーシスを介したヒト膀胱癌細胞でのcyclin D1b knockdownの抗腫瘍活性の検討
    金 哲將, 旦部 幸博, 河内 明宏, 井上 寛一 日本泌尿器科学会総会 105回 OP64 -6 2017年04月 [無し][無し]
  • 女性骨盤臓器脱患者の下部尿路症状に対する腹腔鏡下仙骨腟固定術(LSC)の初期評価
    水流 輝彦, 中川 翔太, 西田 将成, 沖中 勇輝, 窪田 成寿, 富田 圭司, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 荒木 勇雄, 河内 明宏 日本泌尿器科学会総会 105回 PP14 -05 2017年04月 [無し][無し]
  • HoLEPにおける術前尿流動態検査を用いた排尿状態の検討
    花田 英紀, 中川 翔太, 西田 将成, 沖中 勇輝, 窪田 成寿, 富田 圭司, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 105回 PP46 -10 2017年04月 [無し][無し]
  • 最新の高齢者下部尿路機能障害(排尿障害)治療
    河内 明宏 滋賀医学 39 6 -7 2017年03月 [無し][無し]
  • 滋賀県の慢性透析療法の現況(2014年12月31日現在)
    金崎 雅美, 荒木 信一, 河内 明宏, 江口 豊, 秋岡 清一, 門 浩志, 八田 告, 磯野 元秀, 前田 咲弥子, 新井 豊, 西尾 利樹, 安田 和弘, 有村 哲朗, 西村 正孝, 西尾 利二, 一色 啓二, 富田 耕彬, 谷口 正展 滋賀医学 39 8 -12 2017年03月 [無し][無し]
  • 当科における腹腔鏡下腟仙骨腟固定術の初期経験
    水流 輝彦, 吉田 哲也, 花田 英紀, 西田 将成, 中川 翔太, 影山 進, 成田 充弘, 河内 明宏 滋賀医学 39 121 -121 2017年03月 [無し][無し]
  • Gamma-glutamylcyclotransferase(GGCT)の発現低下は乳癌細胞にオートファジーを誘導する
    谷口 恵香, 中田 晋, 松村 健吾, 飯居 宏美, 影山 進, 河内 明宏, 吉貴 達寛 日本薬学会年会要旨集 137年会 (3) 149 -149 2017年03月 [無し][無し]
  • 異所性腎に発生した尿管癌の1例
    前田 航規, 岡田 裕作, 影山 進, 成田 充弘, 河内 明宏 泌尿器科紀要 63 (2) 75 -79 2017年02月 [無し][無し]
     
    83歳男。左大腿骨頸部骨折にて緊急入院時に肉眼的血尿を認め、尿細胞診でclass IV、CTで右尿管腫瘍と右尿管口部に3cm大の膀胱腫瘍が認められた。TURBTを行い、右尿管口部の膀胱腫瘍はinvasive urothelial carcinomaであった。膀胱鏡では膀胱内は浮遊物で混濁し中等度の肉柱形成を認め、右尿管口部にはTURBT後の瘢痕を認め、右尿管口は同定できなかった。単純CTでは右腎は萎縮し、L4レベルに存在、右尿管壁は肥厚し、内部濃度の上昇を認めた。右尿管腫瘍は増大傾向で右腎萎縮は進行していた。restaging TURBTを行ったところ、右尿管口は同定できず、右尿管口周辺のTURBT瘢痕を含め切除した。病理所見では異型尿路上皮細胞は膀胱筋層に浸潤しており、urothelial carcinoma、highgrade、G3、pT2と診断された。右腎尿管全摘術および右尿管部の膀胱部分切除術を施行、摘出標本の病理所見から右尿管癌pT3N0M0、stage IIIと診断された。術後1ヵ月、再発は認めていない。
  • 村井亮介, 影山進, 富田圭司, 小林憲市, 河内明宏, 伊藤靖, 仲山美沙子, 石垣宏仁, 寺本和雄, 小笠原一誠 日本泌尿器科学会中部総会プログラム・抄録集 67th 180 2017年 [無し][無し]
  • 【新薬展望2017】(第III部)治療における最近の新薬の位置付け<薬効別> 新薬の広場 排尿障害治療薬
    水流 輝彦, 河内 明宏 医薬ジャーナル 53 (増刊) 500 -505 2017年01月 [無し][無し]
     
    下部尿路症状は,「排尿症状」,「畜尿症状」,「排尿後症状」に大別される。排尿症状,蓄尿症状それぞれの障害に対して,まず薬物治療が行われることが多く,排尿症状では男性における前立腺肥大症治療が,蓄尿症状では過活動膀胱がその代表である。前立腺肥大症治療薬は2014年にPDE5(ホスホジエステラーゼタイプ5)阻害薬であるタダラフィル以降上市された新薬はない。過活動膀胱治療薬も2011年にβ3刺激薬のミラベグロンと,2013年に抗コリン薬のフェソテロジン,オキシブチニン経皮吸収型製剤が薬価収載された後は上市されていない。排尿筋収縮力が低下する低活動膀胱では,長年新薬は上市されていない。第III相試験が進行している薬剤もKRP-114V(ヒベグロン),GSK1358820(A型ボツリヌス毒素)の2剤のみである。難治性過活動膀胱治療薬として期待される,第III相試験が始まったボツリヌストキシンに関して述べる。(著者抄録)
  • 前立腺癌尿管転移の1例
    西田 将成, 水流 輝彦, 瀧本 啓太, 河内 明宏 泌尿器科紀要 63 (1) 39 -39 2017年01月 [無し][無し]
  • ステロイド投与が奏効した好酸球性膀胱炎の1例
    沖中 勇輝, 上仁 数義, 西田 将成, 花田 英紀, 影山 進, 成田 充弘, 河内 明宏 泌尿器科紀要 63 (1) 42 -42 2017年01月 [無し][無し]
  • 膀胱鏡を併用した単孔式腹腔鏡下膀胱部分切除術を施行した膀胱Paragangliomaの1例
    広田 竜一, 水流 輝彦, 前田 航規, 城 文泰, 永澤 誠之, 和田 晃典, 瀧本 啓太, 吉田 哲也, 上仁 数義, 影山 進, 成田 充弘, 河内 明宏, 岡田 裕作 泌尿器科紀要 62 (12) 671 -671 2016年12月 [無し][無し]
  • 女性骨盤臓器脱患者の下部尿路症状に対するTVM・LSC手術の効果
    水流 輝彦, 中川 翔太, 西田 将成, 沖中 勇輝, 花田 英紀, 吉田 哲也, 荒木 勇雄, 河内 明宏 日本排尿機能学会誌 27 (1) 235 -235 2016年12月 [無し][無し]
  • 泌尿器科領域における単孔式手術ならびにReduced Port Surgeryの進化 本邦の副腎手術における単孔式およびReduced Port腹腔鏡手術の現状
    成田 充弘, 河内 明宏, 三股 浩光, 佐藤 文憲, 桶川 隆嗣, 羽渕 友則, 星 昭夫, 松原 昭郎, 吉村 耕治, 木下 秀文, 中川 健 日本内視鏡外科学会雑誌 21 (7) WS17 -1 2016年12月 [無し][無し]
  • ソフト凝固を使用した腹腔鏡下腎部分切除術は仮性腎動脈瘤の発生を減少できる
    吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 21 (7) OS196 -3 2016年12月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏 泌尿器外科 29 (11) 1647 -1653 2016年11月 [無し][無し]
     
    小児泌尿器科疾患に対する単孔式腹腔鏡手術の幕開けは、2009年Parkらによる萎縮腎に対する単純腎摘除術である。その後様々な手術に応用され、摘除術(腎摘除術、腎尿管摘除術、半腎部摘除術など)や形成術(腎盂形成術、精巣固定術、精索静脈瘤根治術、順行性浣腸路造設術など)が行われている。小児泌尿器疾患はほとんどが良性疾患であり、手術成績が同等であれば、術創の少ない単孔式腹腔鏡手術が理想的である。(著者抄録)
  • 泌尿器科領域における蛍光ナビゲーションの現状および展望 当院におけるICG蛍光法によるReal time angiography
    吉田 哲也, 西田 将成, 沖中 勇輝, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 29 (3) 117 -117 2016年11月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏 Japanese Journal of Endourology 29 (3) 131 -131 2016年11月 [無し][無し]
  • 小林 憲市, 村井 亮介, 富田 圭司, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 29 (3) 141 -141 2016年11月 [無し][無し]
  • 富田 圭司, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 29 (3) 183 -183 2016年11月 [無し][無し]
  • ソフト凝固システムを併用したロボット支援腹腔鏡下腎部分切除術
    吉田 哲也, 西田 将成, 沖中 勇輝, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 29 (3) 241 -241 2016年11月 [無し][無し]
  • 影山 進, 吉田 哲也, 花田 英紀, 永澤 誠之, 窪田 成寿, 富田 圭司, 水流 輝彦, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 29 (3) 268 -268 2016年11月 [無し][無し]
  • 本邦の副腎手術における単孔式およびReduced Port腹腔鏡手術の現状
    成田 充弘, 影山 進, 吉田 哲也, 花田 英紀, 河内 明宏, 三股 浩光 Japanese Journal of Endourology 29 (3) 304 -304 2016年11月 [無し][無し]
  • 精索静脈瘤に対する腹腔鏡下高位結紮術における工夫
    富田 圭司, 西田 将成, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本生殖医学会雑誌 61 (4) 353 -353 2016年10月 [無し][無し]
  • 馬塲 雅人, 富田 圭司, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会雑誌 107 (4) 271 -275 2016年10月 [無し][無し]
     
    症例は25歳、男性。主訴は左陰嚢痛。小学生の頃より左右の精巣の大きさや形状の違いを自覚していたが、放置していた。2011年1月、陰嚢痛を自覚し当科受診、触診で左陰嚢に有痛性の表面平滑な硬い腫瘤を認めた。採血上、精巣腫瘍マーカーは正常で、超音波断層検査では正常精巣を圧排する形で、陰嚢内に嚢胞性病変と結節病変を認めた。造影MRIで多嚢胞性病変と内部に出血性変化、充実性の結節病変を認めた。以上より、良性腫瘍を疑い精巣温存手術を予定し、術中迅速病理診断で悪性であれば高位精巣摘除術に移行することとした。精巣を冷阻血し、腫瘍を核出した。術中迅速病理診断は成熟奇形腫で、悪性所見がないことより予定通り正常精巣組織を温存した。全割病理検査の結果は単一型成熟奇形腫であった。術後5年経過して再発を認めていない。成人においても、思春期以前に発症したと考えられる成熟奇形腫に対しては精巣温存手術も考慮できる。(著者抄録)
  • ヒト膀胱癌細胞に対するCyclin D1b siRNAの抗腫瘍活性の検討
    金 哲將, 旦部 幸博, 河内 明宏, 井上 寛一 日本癌学会総会記事 75回 P -2071 2016年10月 [無し][無し]
  • CDKI誘導を介したγ-グルタミルシクロトランスフェラーゼの抑制による細胞老化誘導
    松村 健吾, 中田 晋, 飯居 宏美, 芦原 英司, 影山 進, 河内 明宏, 吉貴 達寛 日本癌学会総会記事 75回 P -3136 2016年10月 [無し][無し]
  • 膀胱 筋層非浸潤性膀胱がんの臨床 筋層非浸潤膀胱癌における制御性T細胞の病理組織学的検討
    村井 亮介, 仲山 美沙子, 影山 進, 石垣 宏仁, 寺本 和雄, 伊藤 靖, 富田 圭司, 小林 憲市, 和田 晃典, 永澤 誠之, 窪田 成寿, 小笠原 一誠, 河内 明宏 日本癌治療学会学術集会抄録集 54回 MS2 -2 2016年10月 [無し][無し]
  • 低リスク筋層非浸潤性膀胱癌再発予防におけるピラルビシン短時間単回膀注療法
    窪田 成寿, 影山 進, 花田 英紀, 永澤 誠之, 水流 輝彦, 吉田 哲也, 上仁 数義, 成田 充弘, 金 哲將, 河内 明宏 日本癌治療学会学術集会抄録集 54回 P46 -5 2016年10月 [無し][無し]
  • 転移巣の起源に苦慮した同時多発転移の1例
    藤原 遼, 成田 充弘, 影山 進, 河内 明宏, 仲山 貴永, 西 奈津実, 杉原 洋行, 岡田 裕作 泌尿器科紀要 62 (9) 473 -477 2016年09月 [無し][無し]
     
    67歳男。左頸部・前胸部・左上腕の浮腫を主訴とした。腎癌(淡明細胞癌)と胃癌(低分化腺癌)の既往があり、予後規定因子を胃癌として治療を優先したが、4ヵ月後に主訴が出現した。胸腹部CTで左鎖骨下静脈血栓症、両肺野の多発肺結節影と左胸水貯留、膵頭部の腫瘤影を認め、左胸水細胞診はCD10陰性であったが、細胞形態的に淡明細胞癌と診断された。臨床画像から血栓症の原因は腎癌の転移と診断し、胃癌の化学療法を中止してsunitinibを開始したが、急激な全身状態の悪化により20日目に死亡した。剖検では両側肺の脈管内に胃癌由来の腫瘍塞栓と血栓、両側肺水腫を認め、腎癌は肺、膵臓への転移のみであり、死因は胃癌による肺腫瘍塞栓および肺水腫による呼吸不全と考えられた。
  • 沖中 勇輝, 成田 充弘, 和田 晃典, 吉田 哲也, 影山 進, 河内 明宏 泌尿器外科 29 (8) 1287 -1290 2016年08月 [無し][無し]
     
    今回われわれの施設ではCRPCに対する新規ホルモン剤の治療効果に関して検討した。PSA奏効率はエンザルタミド使用群(Enz群)52%、アビラテロン使用群(Abi)群20%と臨床試験と比して治療効果は劣っていた。ドセタキセルおよび他方の新規ホルモン剤使用前の症例に限れば治療効果は臨床試験と遜色ない結果であった。PSA無再発期間は中央値でEnz群6.0ヵ月、Abi群4.0ヵ月であった。有害事象による中止はEnz群21%に対してAbi群は3%であった。どちらの薬剤も症例の選択は必要だが奏効率も高く有効性に期待できる薬剤と考えられた。(著者抄録)
  • 河内 明宏, 上仁 数義, 小林 憲市 泌尿器外科 29 (7) 1133 -1138 2016年07月 [無し][無し]
     
    排尿と睡眠の機構が大人型になる5歳以降になっても持続する夜尿を病的と考え、夜尿症と呼ぶ。国際的な定義では月1回を超える夜尿が3ヵ月以上続くものとされている。夜尿症の原因としては、基礎疾患のほかは覚醒障害、夜間多尿、膀胱容量の低下の3つが重要である。夜尿症の治療法には生活指導、夜尿アラーム療法、抗利尿ホルモン、三環系抗うつ薬、抗コリン薬などがある。International Children's Continence Societyによる治療指針においては、まず生活指導を行い、それが無効の場合は夜尿アラームと抗利尿ホルモンのどちらかを使用することが勧められている。(著者抄録)
  • 小児膀胱尿管逆流症に対する気膀胱下Cohen法の初期経験
    赤澤 早紀, 大豆本 圭, 津田 恵, 楠原 義人, 森 英恭, 新谷 晃理, 香川 純一郎, 山本 恭代, 山口 邦久, 福森 知治, 高橋 正幸, 金山 博臣, 河内 明宏 西日本泌尿器科 78 (7) 362 -362 2016年07月 [無し][無し]
  • 転移性腎癌に対するパゾパニブ治療の臨床的検討
    吉田 哲也, 西田 将成, 窪田 成寿, 富田 圭司, 水流 輝彦, 花田 英紀, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏, 野田 哲史, 寺田 智祐 腎癌研究会会報 (46) 48 -48 2016年07月 [無し][無し]
  • Nocturnal polyuriaに対するDDAVPとアラーム療法の長期成績
    内藤 泰行, 安食 淳, 山田 恭弘, 藤原 敦子, 沖原 宏治, 河内 明宏, 浮村 理 日本夜尿症学会学術集会プログラム・抄録集 27回 35 -35 2016年07月 [無し][無し]
  • Bristol stool scaleは、夜尿や昼間尿失禁と治療効果予測因子とはなり得ない
    小林 憲市, 上仁 数義, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 成田 充宏, 河内 明宏 日本夜尿症学会学術集会プログラム・抄録集 27回 46 -46 2016年07月 [無し][無し]
  • 神経発達障害における尿失禁への心理社会的問題の影響
    澤井 ちひろ, 阪上 由子, 西倉 紀子, 高萩 恭子, 竹内 義博, 上仁 数義, 小林 憲市, 河内 明宏 日本夜尿症学会学術集会プログラム・抄録集 27回 47 -47 2016年07月 [無し][無し]
  • 小林 憲市, 上仁 数義, 花田 英紀, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本小児泌尿器科学会雑誌 25 (3) 217 -217 2016年06月 [無し][無し]
  • 内藤 泰行, 安食 淳, 金光 博樹, 迫 智之, 多賀 英人, 山田 恭弘, 藤原 敦子, 本郷 文弥, 鴨井 和実, 沖原 宏治, 河内 明宏, 浮村 理 日本小児泌尿器科学会雑誌 25 (3) 265 -265 2016年06月 [無し][無し]
  • 永澤 誠之, 影山 進, 金 哲將, 水流 輝彦, 花田 英紀, 吉田 哲也, 上仁 数義, 成田 充弘, 石田 光明, 河内 明宏 泌尿器外科 29 (5) 511 -515 2016年05月 [無し][無し]
     
    筋層非浸潤性膀胱癌における術直後抗癌剤注入の治療効果について検討した。対象は、当院にてTUR-Btを施行し、CISやWHO1973年分類のgrade3症例を除いたpTa症例とした。ピノルビン30mg/40mLを用いた膀胱内注入を3群に分け、再発率を後方視的に検討した。I群は術直後注入のみ、II群は週1回10週間の導入療法のみ、III群は術直後注入と導入療法の両方を施行した。I群の3年非再発率は25%と低く、再発予防効果は不十分と考えられた。II群、III群の3年非再発率はそれぞれ53.8%、63.1%であり、それらに有意差はなかった。自験例では術直後注入の導入療法への相加効果は明らかではなかった。(著者抄録)
  • 【新前立腺癌学-最新の基礎研究と診断・治療-】 前立腺癌の検査・診断 前立腺生検 再生検の適応と意義
    影山 進, 成田 充弘, 河内 明宏 日本臨床 74 (増刊3 新前立腺癌学) 359 -362 2016年05月 [無し][無し]
  • Keiji Tomita, Eiki Hanada, Susumu Kageyama, Kazuyoshi Johnin, Mitsuhiro Narita, Akihiro Kawauchi JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 195 (4) E1004 -E1004 2016年04月 [無し][無し]
  • Second-TUR施行後のT1膀胱癌に対するBCG膀胱内注入療法の治療効果
    馬塲 雅人, 影山 進, 鄭 裕午, 長谷 行洋, 河内 明宏 泌尿器外科 29 (4) 401 -403 2016年04月 [無し][無し]
     
    Second-TUR施行後のT1膀胱癌に対するBCG膀胱内注入療法の治療効果について検討した。初回TUR標本で病期T1と診断した119例(男性104名、女性15名、31〜90歳)を対象として、後ろ向きに検討した。Second-TUR施行群は42例、非施行群は77例であった。CIS併発を11例で認めた。BCG注入療法は46例に行われ、その中でsecond-TURの施行群は24例、非施行群は22例であった。BCG注入療法非施行群73例は抗癌剤注入療法が32例、TUR単独が41例に行われた。Second-TURにおける残存癌は25例に認めたが、up-stagingはみられなかった。Second-TURの有無での非再発率(1年/5年)はS+群で67.5%/36.6%、S-群で64.8%/46.9%であった。BCG施行群ではS-群とS+群の非再発率に有意差はないもののS+群で非再発率が高い傾向にあった。
  • 副腎皮質腺腫を伴った副腎髄質過形成の2症例
    中泉 伸彦, 布施 恵子, 山本 有香子, 根本 憲一, 辻 知里, 関根 理, 森野 勝太郎, 卯木 智, 西田 将成, 永澤 誠之, 成田 充弘, 河内 明宏, 苗村 智, 久嶋 亮治, 前川 聡 日本内分泌学会雑誌 92 (1) 254 -254 2016年04月 [無し][無し]
  • 去勢抵抗性前立腺癌に対するアビラテロンの初期治療経験
    沖中 勇輝, 成田 充弘, 西田 将成, 前田 航規, 窪田 成寿, 永澤 誠之, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏, 金 哲將, 曽我 弘樹 泌尿器科紀要 62 (4) 209 -209 2016年04月 [無し][無し]
  • 筋層非浸潤膀胱癌の再発に関連する免疫抑制性細胞の病理組織学的検討
    村井 亮介, 仲山 美沙子, 影山 進, 寺本 和雄, 和田 晃典, 小林 憲市, 富田 圭司, 花田 英紀, 小笠原 一誠, 河内 明宏 日本泌尿器科学会総会 104回 PP1 -042 2016年04月 [無し][無し]
  • 進行尿路上皮癌に対するGP(ゲムシタビン・パクリタキセル)化学療法の検討
    影山 進, 永澤 誠之, 窪田 成寿, 西田 将成, 小林 憲市, 富田 圭司, 村井 亮介, 水流 輝彦, 花田 英紀, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 PP1 -065 2016年04月 [無し][無し]
  • 体積40ccを超える症例に対する小線源単独療法の治療クオリティ評価
    岡本 圭生, 河野 直明, 柳 勇也, 野間 和夫, 橋本 恵輔, 村田 喜代史, 河内 明宏, 村上 義孝 日本泌尿器科学会総会 104回 PP1 -344 2016年04月 [無し][無し]
  • 低リスク筋層非浸潤性膀胱癌に対するTURBT後の塩酸ピラルビシン短時間即時単回注入療法の治療成績
    窪田 成寿, 影山 進, 永澤 誠之, 水流 輝彦, 花田 英紀, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏, 佐野 太一, 金 哲將 日本泌尿器科学会総会 104回 PP2 -055 2016年04月 [無し][無し]
  • 当院における導尿型代用膀胱の長期成績
    永澤 誠之, 影山 進, 窪田 成寿, 小林 憲市, 富田 圭司, 村井 亮介, 水流 輝彦, 花田 英紀, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 PP2 -062 2016年04月 [無し][無し]
  • 本邦における小児泌尿器科領域のおけるLESS・RPSの現状 本邦における泌尿器単孔式およびReduced Port腹腔鏡手術の実態調査のサブグループ解析
    小林 憲市, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 PP2 -165 2016年04月 [無し][無し]
  • 腎盂尿管移行部通過障害にたいするロボット支援腹腔鏡下腎盂形成術の初期経験 腹腔鏡下単孔式腎盂形成術との比較
    上仁 数義, 西田 将成, 前田 航規, 永澤 誠之, 窪田 成寿, 小林 憲市, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 OP -154 2016年04月 [無し][無し]
  • ロボット支援腹腔鏡下前立腺摘除術におけるICG蛍光法を利用したリンパ節郭清術の治療経験
    花田 英紀, 成田 充弘, 西田 将成, 前田 航規, 窪田 成寿, 永澤 誠之, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏 日本泌尿器科学会総会 104回 VP -21 2016年04月 [無し][無し]
  • ICG蛍光血管造影を併用した単孔式腹腔鏡下精索静脈瘤高位結紮術の経験
    富田 圭司, 西田 将成, 前田 航規, 沖中 勇輝, 窪田 成寿, 永澤 誠之, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 OP -101 2016年04月 [無し][無し]
  • ミラベグロン服薬継続率の検討
    水流 輝彦, 窪田 成寿, 永澤 誠之, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 PP2 -292 2016年04月 [無し][無し]
  • 去勢抵抗性前立腺癌に対する新規ホルモン剤の初期治療成績
    和田 晃典, 成田 充弘, 窪田 成寿, 永澤 誠之, 村井 亮介, 小林 憲一, 富田 圭司, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏 日本泌尿器科学会総会 104回 OP -309 2016年04月 [無し][無し]
  • 泌尿器疾患に対するReduced Port Surgery これからの展開は? 本邦における泌尿器単孔式およびReduced Port腹腔鏡手術の実態調査
    成田 充弘, 河内 明宏, 三股 浩光, 日本泌尿器内視鏡学会泌尿器LESS・RPS検討部会 日本泌尿器科学会総会 104回 FS24 -1 2016年04月 [無し][無し]
  • 泌尿器疾患に対するReduced Port Surgery これからの展開は? 小児泌尿器科疾患に対するReduced Port Surgery
    内藤 泰行, 山田 恭弘, 藤原 敦子, 本郷 文弥, 納谷 佳男, 鴨井 和実, 沖原 宏治, 河内 明宏, 浮村 理 日本泌尿器科学会総会 104回 FS24 -2 2016年04月 [無し][無し]
  • 阻血方法の違いによる腹腔鏡下腎部分切除術前後の腎機能の比較
    吉田 哲也, 西田 将成, 窪田 成寿, 永澤 誠之, 小林 憲市, 村井 亮介, 富田 圭司, 水流 輝彦, 花田 英紀, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 104回 PP3 -203 2016年04月 [無し][無し]
  • 尿路上皮癌に対するnedaplatin併用化学療法施行時の腎機能の検討
    永澤 誠之, 影山 進, 前田 航規, 城 文泰, 広田 竜一, 和田 晃典, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏 滋賀医学 38 96 -96 2016年03月 [無し][無し]
  • 直腸脱を合併した腟断端脱、直腸瘤に対して腹腔鏡下に一期的に修復術を施行した1例
    太田 裕之, 園田 寛道, 清水 智治, 植木 智之, 谷 眞至, 水流 輝彦, 吉田 哲也, 西田 将成, 河内 明宏 滋賀医学 38 124 -124 2016年03月 [無し][無し]
  • 自然破裂を来した腎血管筋脂肪腫に対してTAE後、無阻血、無縫合腹腔鏡下腎部分切除術を施行した1例
    前田 航規, 西田 将成, 沖中 勇輝, 窪田 成寿, 永澤 誠之, 吉田 哲也, 成田 充弘, 影山 進, 河内 明宏 滋賀医学 38 126 -127 2016年03月 [無し][無し]
  • 不妊を契機に発見されhCG-FSH療法を施行したカルマン症候群の1例
    富田 圭司, 鄭 裕午, 城 文泰, 永澤 誠之, 和田 晃典, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 岡本 圭生, 成田 充弘, 河内 明宏 泌尿器科紀要 62 (3) 154 -154 2016年03月 [無し][無し]
  • 尿路上皮癌に対するNedaplatin併用化学療法施行時の腎機能の検討
    永澤 誠之, 影山 進, 前田 航規, 城 文泰, 鄭 裕午, 和田 晃典, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 成田 充弘, 岡本 圭生, 河内 明宏 泌尿器科紀要 62 (3) 155 -155 2016年03月 [無し][無し]
  • 腹腔鏡下根治的前立腺全摘除術における尿禁制回復までの期間に関する検討 術前IPSSは予測因子となりうるか
    鄭 裕午, 水流 輝彦, 影山 進, 吉田 哲也, 成田 充弘, 富田 圭司, 花田 英紀, 上仁 数義, 河内 明宏 泌尿器科紀要 62 (3) 156 -156 2016年03月 [無し][無し]
  • 草場 拓人, 長船 崇, 永澤 誠之, 関岡 敏夫, 滝本 見吾, 成田 充弘, 河内 明宏 日本泌尿器科学会雑誌 107 (1) 39 -43 2016年01月 [無し][無し]
     
    症例は75歳男性。前立腺癌cT2cN0M0の診断で腹腔鏡下前立腺全摘除術を施行した。術中に明らかな直腸損傷を認めず、術後6日目の膀胱尿道造影にて吻合部からの溢流なく尿道カテーテルを抜去し退院となった。術後21日目より気尿、膿尿、水様性下痢が出現し、大腸内視鏡および直腸造影検査にて尿道直腸瘻と診断した。自然閉鎖を認めず、前立腺全摘除術後4ヵ月目にポリグリコール酸(PGA)フェルト・フィブリン糊を用いた大腸内視鏡下被覆術を施行し、症状は改善した。内視鏡治療後20ヵ月経過し、尿道直腸瘻の再発は認めていない。前立腺全摘除術の合併症としての尿道直腸瘻の頻度は少ないが、治療に難渋することが多い。このPGAフェルト・フィブリン糊を用いた大腸内視鏡下被覆術は簡単に施行でき低侵襲である。瘻孔径の小さいものに対しては外科的治療を行う前にこの大腸内視鏡下被覆術を試みる価値があるのではないかと考える。(著者抄録)
  • 女性骨盤臓器脱患者のTVM手術におけるQOL変化の検討 P-QOLによる検討
    水流 輝彦, 荒木 勇雄, 城 文泰, 鄭 裕午, 広田 竜一, 馬塲 雅人, 吉田 哲也, 河内 明宏 日本女性骨盤底医学会誌 12 (1) 135 -138 2015年12月 [無し][無し]
     
    女性骨盤底障害の主要な疾患である骨盤臓器脱のため排尿障害をはじめとするQOLは障害され、骨盤臓器脱手術はそのQOLの改善を目的として行われる。今回われわれは2011年8月から2013年3月に当院でTVM(Tension-free vaginal mesh)手術を施行した58名を対象とし、手術前後のQOL変化をProlapse quality of life questionnaire(P-QOL)の日本語暫定版を用いて検討した。P-QOLは、全般的な健康(P=0.0039)、骨盤臓器脱の影響(p<0.0001)、心の問題(p<0.0001)、骨盤臓器脱の問題(P=0.0003)は1ヵ月後より有意に改善し、12ヵ月後まで維持した。仕事・家事の制限(RL)、身体的制限(PL)、社会的活動の制限(SL)、睡眠・活力(SE)は3ヵ月後よりそれぞれ有意な改善を認めた。一方、個人的な人間関係(PR)では有意な変化はなかった。TVM手術により排尿障害は有意に改善した。全般的なQOLも、個人的な人間関係を除いて有意な改善を認めた。(著者抄録)
  • 腹腔鏡/ロボット支援手術におけるイメージナビゲーション ICG近赤外蛍光補助下腹腔鏡下腎部分切除術
    吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 20 (7) SY13 -3 2015年12月 [無し][無し]
  • 誰も教えてくれない手術機器のうまい使い方 ソフト凝固 ソフト凝固を用いた腹腔鏡下腎部分切除術
    吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 20 (7) WS31 -7 2015年12月 [無し][無し]
  • 腎・副腎に対する単孔式腹腔鏡手術 小児泌尿器科疾患に対する単孔式腹腔鏡手術 腎盂形式術・腎摘を中心に
    内藤 泰行, 山田 恭弘, 小林 憲市, 上仁 数義, 藤原 敦子, 本郷 文弥, 納谷 佳男, 鴨井 和実, 沖原 宏治, 河内 明宏 日本内視鏡外科学会雑誌 20 (7) PD17 -1 2015年12月 [無し][無し]
  • 腎盂尿管移行部通過障害にたいするロボット支援腹腔鏡下腎盂形成術の初期経験
    上仁 数義, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 20 (7) OS46 -4 2015年12月 [無し][無し]
  • ロボット支援前立腺摘除術におけるICG蛍光法を利用した拡大リンパ節郭清術の治療経験
    成田 充弘, 影山 進, 吉田 哲也, 上仁 数義, 河内 明宏 日本内視鏡外科学会雑誌 20 (7) OS88 -6 2015年12月 [無し][無し]
  • 尿閉を来たした傍尿道平滑筋腫の1例
    前田 航規, 城 文泰, 広田 竜一, 永澤 誠之, 和田 晃典, 小林 憲市, 富田 圭司, 水流 輝彦, 花田 英紀, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 泌尿器科紀要 61 (12) 528 -528 2015年12月 [無し][無し]
  • 2年弱の経過にて123I-MIBGシンチグラフィにて新たな集積を認めた、副腎皮質腺腫を伴った副腎髄質過形成の一例
    布施 恵子, 関根 理, 中泉 伸彦, 山本 有香子, 佐藤 大介, 根本 憲一, 楠 知里, 森野 勝太郎, 卯木 智, 西田 将成, 成田 充弘, 河内 明宏, 前川 聡 日本内分泌学会雑誌 91 (Suppl.Branch) 247 -247 2015年12月 [無し][無し]
  • Tomohiro Terada, Satoshi Noda, Takashi Otsuji, Daiki Hira, Shin-ya Morita, Tetsuya Yoshida, Susumu Kageyama, Keisei Okamoto, Akihiro Kawauchi DRUG METABOLISM REVIEWS 研究発表ペーパー・要旨(国際会議) 47 237 -238 2015年11月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏, 内藤 泰行 Japanese Journal of Endourology 28 (3) 140 -140 2015年11月 [無し][無し]
  • ICG近赤外蛍光補助下腹腔鏡下腎部分切除術
    吉田 哲也, 前田 航規, 沖中 勇輝, 窪田 成寿, 永澤 誠之, 水流 輝彦, 花田 英紀, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 28 (3) 163 -163 2015年11月 [無し][無し]
  • 腎血管筋脂肪腫の自然破裂に対するTAE後、無阻血腹腔鏡下腎部分切除術を施行した1例
    窪田 成寿, 西田 将成, 前田 航規, 沖中 勇輝, 永澤 誠之, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 28 (3) 182 -182 2015年11月 [無し][無し]
  • 水流 輝彦, 吉田 哲也, 西田 将成, 花田 英紀, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 28 (3) 195 -195 2015年11月 [無し][無し]
  • 上仁 数義, 前田 航規, 永澤 誠之, 小林 憲市, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 28 (3) 207 -207 2015年11月 [無し][無し]
  • 成田 充弘, 河内 明宏, 桶川 隆嗣, 木下 秀文, 佐藤 文憲, 中川 健, 羽渕 友則, 星 昭夫, 松原 昭郎, 吉村 耕治, 三股 浩光 Japanese Journal of Endourology 28 (3) 215 -215 2015年11月 [無し][無し]
  • 永澤 誠之, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 草場 拓人, 長船 崇, 河内 明宏 Japanese Journal of Endourology 28 (3) 237 -237 2015年11月 [無し][無し]
  • 当院における腹腔鏡下腎部分切除術の臨床的検討
    佐竹 宏文, 島本 力, 深田 聡, 蘆田 真吾, 辛島 尚, 井上 啓史, 執印 太郎, 繁田 正信, 白木 良一, 河内 明宏 Japanese Journal of Endourology 28 (3) 262 -262 2015年11月 [無し][無し]
  • ロボット支援腹腔鏡下根治的膀胱全摘除術の初期経験
    影山 進, 水流 輝彦, 永澤 誠之, 瀧本 啓太, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 28 (3) 266 -266 2015年11月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏 チャイルド ヘルス 18 (11) 811 -814 2015年11月 [無し][無し]
  • 尿閉を来たした女性傍尿道平滑筋腫の1例
    前田 航規, 和田 晃典, 影山 進, 瀧本 啓太, 成田 充弘, 河内 明宏 泌尿器科紀要 61 (11) 455 -458 2015年11月 [無し][無し]
     
    44歳女。尿閉を主訴とした。子宮筋腫の既往があり、尿閉との関連を疑って婦人科を受診したところ、経腟エコーで膀胱左前方の腫瘤を指摘され、紹介受診となった。内診では尿道左側に表面平滑で境界明瞭な腫瘤を触知し、骨盤部MRI検査では尿道と膀胱に接してT1強調像で筋肉と等信号、T2強調像で筋肉より高信号を呈する9cm大の腫瘍を認めた。針生検では核異型に乏しく好酸性細胞質を有する紡錘形細胞が束を形成して増殖しており、免疫染色はdesmin、SMAが陽性でspindle cell tumor in the pelvisと診断され、悪性所見は認めなかった。経腹的および経腟的アプローチにて腫瘍を摘除し、病理組織学的所見より傍尿道平滑筋腫と診断した。術後3ヵ月経過現在、再発を認めていない。
  • 尿道転移を認めた去勢抵抗性前立腺癌の1例
    鄭 裕午, 和田 晃典, 前田 航規, 城 文泰, 永澤 誠之, 水流 輝彦, 小林 憲市, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 岡本 圭生, 成田 充弘, 河内 明宏 泌尿器科紀要 61 (11) 469 -469 2015年11月 [無し][無し]
  • 画像検査にて両側精巣腫瘍が疑われた左精巣Seminomaの1例
    和田 晃典, 前田 航規, 城 文泰, 鄭 裕午, 永澤 誠之, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 影山 進, 岡本 圭生, 成田 充弘, 河内 明宏 泌尿器科紀要 61 (11) 471 -471 2015年11月 [無し][無し]
  • 【プライマリーケアにおける救急患者の診断と初期治療】 腹部症状 尿閉
    水流 輝彦, 河内 明宏 臨牀と研究 92 (10) 1282 -1284 2015年10月 [無し][無し]
  • 永澤 誠之, 上仁 数義, 佐野 太一, 小林 憲市, 影山 進, 成田 充弘, 岡本 圭生, 河内 明宏 日本泌尿器科学会雑誌 106 (4) 289 -292 2015年10月 [無し][無し]
     
    6ヵ月、男児。主訴は左陰嚢腫大。生後3ヵ月頃より陰嚢の腫大を認め、当科紹介。左陰嚢は触診上、表面平滑で弾性硬、超音波検査で精巣内に充実成分を伴わない約2cmの単一な嚢胞性病変を認めた。AFP、hCG、LDHは正常範囲内であったため、単純性精巣嚢胞もしくは良性の精巣腫瘍が疑われた。術中迅速病理検査にて悪性所見を認めず、精巣温存手術を施行した。病理検査で、嚢胞壁は内腔を一層の立方上皮に囲まれた線維性被膜が多くを占め、嚢胞壁の一部から扁平上皮成分、軟骨成分、腸上皮成分を認めたため、成熟奇形腫と診断した。術後4年経過し、左側精巣の萎縮や再発は認めていない。(著者抄録)
  • マウス膀胱癌同所性モデルにおいてペリオスチンはAkt/mTORシグナル経路を介して浸潤・造腫瘍活性を抑制する
    金 哲將, 旦部 幸博, 向所 賢一, 杉原 洋行, 河内 明宏, 井上 寛一 日本癌学会総会記事 74回 P -2044 2015年10月 [無し][無し]
  • 上仁 数義, 永澤 誠之, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 28 (2) 247 -252 2015年09月 [無し][無し]
     
    【目的】単孔式腹腔鏡下腎盂形成術(LESS-P)は、開放腎盂形成術(OP)、腹腔鏡下腎盂形成術(LP)に比べると術創が小さく整容性に優れている。3つの術式の手術成績、合併症について比較することで、LESS-Pが、腎盂尿管移行部通過障害の標準術式になりうるかを検討した。【方法】2001-2014年にDismembered pyeloplastyを施行したOP群31例(平均5.5歳)、LP群10例(平均28.7歳)、LESS-P群5例(平均36.4歳)を対象とし、手術成績、合併症について検討した。【成績】再手術を要した例を除き、全症例で水腎症は軽快改善した。OP群は他群よりも経口開始が有意に早かったが、手術時間、再手術率、Clavien-Dindo Grade III以上の合併症率、鎮痛剤の使用回数、術後在院日数は、3群間で差を認めなかった。【結論】LESS-Pは、手術成績、合併症においてもOP、LPと同等で、高い整容性からも標準術式になりうると考えられた。(著者抄録)
  • 去勢抵抗性前立腺癌に対する新規ホルモン剤の初期治療経験
    成田 充弘, 和田 晃典, 花田 英紀, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏 日本癌治療学会誌 50 (3) 809 -809 2015年09月 [無し][無し]
  • 透析中の腎細胞患者におけるパゾパニブの薬物動態学的解析 症例報告
    野田 哲史, 平 大樹, 影山 進, 城 文泰, 和田 晃典, 吉田 哲也, 河内 明宏, 森田 真也, 寺田 智祐 日本癌治療学会誌 50 (3) 1891 -1891 2015年09月 [無し][無し]
  • 尿路上皮癌に対するnedaplatin併用化学療法施行時の腎機能の検討
    永澤 誠之, 影山 進, 窪田 成寿, 水流 輝彦, 花田 英紀, 吉田 哲也, 上仁 数義, 成田 充弘, 河内 明宏 日本癌治療学会誌 50 (3) 1941 -1941 2015年09月 [無し][無し]
  • 経皮吸収型過活動膀胱治療剤ネオキシテープ73.5mgは、小児神経因性膀胱の高圧環境を是正する
    上仁 数義, 小林 憲市, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本排尿機能学会誌 26 (1) 168 -168 2015年09月 [無し][無し]
  • 女性骨盤臓器脱患者の下部尿路症状に対するTVM手術の効果 術式による検討
    水流 輝彦, 西田 将成, 前田 航規, 城 文泰, 広田 竜一, 花田 英紀, 吉田 哲也, 荒木 勇雄, 河内 明宏 日本排尿機能学会誌 26 (1) 251 -251 2015年09月 [無し][無し]
  • ICG蛍光内視鏡補助下腹腔鏡下腎部分切除術の経験
    吉田 哲也, 前田 航規, 沖中 勇輝, 窪田 成寿, 永澤 誠之, 水流 輝彦, 花田 英紀, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 腎癌研究会会報 (45) 37 -37 2015年07月 [無し][無し]
  • 多発リンパ節転移を伴って発見された小径腎腫瘍の1例
    城 文泰, 瀧本 啓太, 鄭 裕午, 小林 憲市, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 岡本 圭生, 河内 明宏 泌尿器科紀要 61 (7) 306 -306 2015年07月 [無し][無し]
  • 無阻血腹腔鏡下腎部分切除術の経験
    吉田 哲也, 河内 明宏, 成田 充弘, 影山 進, 本郷 文弥, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 7 (1) 89 -92 2015年07月 [無し][無し]
     
    41例の小径腎腫瘍に対しソフト凝固を用いた無阻血腹腔鏡下腎部分切除術を施行した。平均年齢は60.2歳(30〜86)、平均腫瘍径は23mm(9〜59)、Nephrometry scoreの平均は6.2であった。平均手術時間は276分(184〜334)、平均出血量は92mlであった。3例(7.3%)に腎動脈の阻血を必要とした。腫瘍切除断端は全例陰性で、輸血を行った症例もなかった。尿漏を4例に認めた。術後の腎機能低下は11.1%であった。無阻血腹腔鏡下腎部分切除術は症例を選択すれば安全に施行可能であると考えられた。(著者抄録)
  • 河内 明宏, 上仁 数義, 小林 憲市 日本小児泌尿器科学会雑誌 24 (2) 159 -159 2015年06月 [無し][無し]
  • 小林 憲市, 上仁 数義, 河内 明宏 日本小児泌尿器科学会雑誌 24 (2) 169 -169 2015年06月 [無し][無し]
  • 上仁 数義, 藤原 遼, 永澤 誠之, 佐野 太一, 小林 憲市, 河内 明宏 日本小児泌尿器科学会雑誌 24 (2) 229 -229 2015年06月 [無し][無し]
  • 小林 憲市, 上仁 数義, 前田 航規, 城 文泰, 広田 竜一, 花田 英紀, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充宏, 河内 明宏 日本小児泌尿器科学会雑誌 24 (2) 253 -253 2015年06月 [無し][無し]
  • 小児神経因性膀胱患者に対する経皮吸収型過活動膀胱治療剤ネオキシテープ73.5mgの使用経験
    上仁 数義, 小林 憲市, 河内 明宏 日本夜尿症学会学術集会プログラム・抄録集 26回 40 -40 2015年06月 [無し][無し]
  • 河内 明宏, 上仁 数義, 小林 憲市 泌尿器外科 28 (臨増) 551 -551 2015年05月 [無し][無し]
  • 和田 晃典, 影山 進, 藤原 遼, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 成田 充弘, 岡本 圭生, 河内 明宏 泌尿器外科 28 (臨増) 882 -882 2015年05月 [無し][無し]
  • Teruhiko Tsuru, Ryuichi Hirota, Fumiyasu Jo, Keita Takimoto, Tetsuya Yoshida, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 193 (4) E908 -E908 2015年04月 [無し][無し]
  • 上仁 数義, 小林 憲市, 河内 明宏, 内藤 泰行 泌尿器外科 28 (4) 385 -391 2015年04月 [無し][無し]
     
    腎盂尿管移行部通過障害に対して単孔式腹腔鏡手術(Laparoendoscopic single-site surgery:LESS)を成人および小児患者に施行した。LESSは、臍ポートから5mm軟性腹腔鏡、5mm屈曲鉗子、5mmエナジーデバイスを挿入し、左手用の2mmのポートを追加した。全症例で開放手術や腹腔鏡手術への移行はなく、術後合併症も認めなかった。自覚症状および水腎症は軽快し、腎機能は安定している。術創部は、臍および2mmポートのみで、整容性はきわめて優れていた。(著者抄録)
  • 無阻血腹腔鏡下腎部分切除術の経験
    吉田 哲也, 河内 明宏, 成田 充弘, 影山 進, 本郷 文弥, 三木 恒治 泌尿器外科 28 (4) 505 -505 2015年04月 [無し][無し]
  • VURおよびPUJ stenosis治療の変遷と展望 当科における経膀胱腹腔鏡下逆流防止術
    内藤 泰行, 山田 恭弘, 藤原 敦子, 本郷 文弥, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会総会 103回 385 -385 2015年04月 [無し][無し]
  • 小径腎癌に対する腹腔鏡下無阻血腎部分切除術の有用性
    本郷 文弥, 河内 明宏, 内藤 泰行, 納谷 佳男, 鴨井 和実, 沖原 宏治, 三木 恒治 日本泌尿器科学会総会 103回 453 -453 2015年04月 [無し][無し]
  • マウス膀胱癌同所性モデルを用いたperiostinの抗腫瘍効果の検討
    金 哲將, 旦部 幸博, 河内 明宏, 井上 寛一 日本泌尿器科学会総会 103回 470 -470 2015年04月 [無し][無し]
  • D型アスパラギン酸が精子形成に及ぼす影響の検討
    富田 圭司, 村井 亮介, 花田 英紀, 影山 進, 成田 充弘, 河内 明宏, 田中 裕之, 縣 保年 日本泌尿器科学会総会 103回 482 -482 2015年04月 [無し][無し]
  • Second TURを行った病期T1膀胱癌の検討
    馬塲 雅人, 影山 進, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 岡本 圭生, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 541 -541 2015年04月 [無し][無し]
  • 小径腎腫瘤治療方針決定の為のDiameteraxial-polar nephrometryとR.E.N.A.L nephrometry scoreの比較
    中西 弘之, 納谷 佳男, 上田 崇, 藤原 敦子, 内藤 泰之, 中村 晃和, 本郷 文弥, 鴨井 和美, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会総会 103回 544 -544 2015年04月 [無し][無し]
  • 当院でおこなっている高線量I125小線源単独療法のパラメータと安全性の検討
    岡本 圭生, 河野 直明, 柳 勇也, 野間 和夫, 河内 明宏, 村田 喜代史 日本泌尿器科学会総会 103回 564 -564 2015年04月 [無し][無し]
  • 去勢抵抗性前立腺癌に対するエンザルタミドの初期治療経験
    成田 充弘, 和田 晃典, 影山 進, 吉田 哲也, 長谷 行洋, 曽我 弘樹, 新井 豊, 坂野 祐司, 水流 輝彦, 永澤 誠之, 花田 英紀, 上仁 数義, 河内 明宏 日本泌尿器科学会総会 103回 566 -566 2015年04月 [無し][無し]
  • 膀胱尿管逆流に対する腹腔鏡下膀胱内手術の初期経験
    小林 憲市, 上仁 数義, 前田 航規, 城 文泰, 鄭 裕午, 永澤 誠之, 和田 晃典, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 579 -579 2015年04月 [無し][無し]
  • 当院における根治的膀胱全摘除術を施行した膀胱癌症例の臨床的検討
    永澤 誠之, 影山 進, 和田 晃典, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 岡本 圭生, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 664 -664 2015年04月 [無し][無し]
  • 筋層非浸潤性膀胱癌に対する膀胱内注入温熱化学療法の基礎検討
    花田 英紀, 影山 進, 富田 圭司, 村井 亮介, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 690 -690 2015年04月 [無し][無し]
  • 前立腺癌小線源治療における短期ホルモン療法のBody compositionへの影響
    和田 晃典, 岡本 圭生, 永澤 誠之, 小林 憲市, 水流 輝彦, 花田 英紀, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 720 -720 2015年04月 [無し][無し]
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    水流 輝彦, 荒木 勇雄, 伊狩 亮, 前澤 卓也, 坂野 祐司, 河内 明宏 日本泌尿器科学会総会 103回 732 -732 2015年04月 [無し][無し]
  • 腎部分切除術前後の腎実質体積変化についての検討
    吉田 哲也, 永澤 誠之, 和田 晃典, 小林 憲市, 富田 圭司, 水流 輝彦, 花田 英紀, 瀧本 啓太, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 762 -762 2015年04月 [無し][無し]
  • 滋賀医科大学における腹腔鏡下腎尿管全摘除術の治療成績
    影山 進, 吉田 哲也, 瀧本 啓太, 水流 輝彦, 花田 英紀, 富田 圭司, 城 文泰, 永澤 誠之, 和田 晃典, 小林 憲市, 上仁 数義, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 764 -764 2015年04月 [無し][無し]
  • 単孔式腹腔鏡下腎盂形成術は、標準術式になりうるか?開放、腹腔鏡下手術との比較
    上仁 数義, 永澤 誠之, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 103回 764 -764 2015年04月 [無し][無し]
  • 剖検にて胃癌多発転移が死因と考えられた腎癌術後肺、膵頭部転移の1例
    藤原 遼, 成田 充弘, 城 文泰, 鄭 裕午, 広田 竜一, 山下 寛人, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 岡本 圭生, 荒木 勇雄, 河内 明宏, 仲山 貴永, 杉原 洋行, 岡田 裕作 泌尿器科紀要 61 (3) 126 -126 2015年03月 [無し][無し]
  • 経尿道的に核出しえた膀胱粘膜下腫瘍の1例
    佐野 太一, 九嶋 麻優美, 影山 進, 河内 明宏 泌尿器科紀要 61 (3) 129 -129 2015年03月 [無し][無し]
  • 当院における転移性腎癌に対する分子標的薬の使用経験
    馬場 雅人, 吉田 哲也, 城 文泰, 鄭 裕午, 広田 竜一, 山下 寛人, 小林 憲市, 富田 圭司, 水流 輝彦, 花田 英紀, 瀧本 啓太, 影山 進, 上仁 数義, 成田 充弘, 岡本 圭生, 荒木 勇雄, 河内 明宏, 野田 哲史 滋賀医学 37 119 -119 2015年03月 [無し][無し]
  • 腎結石を合併した先天性水腎症に対して、単孔式腹腔鏡下に腎盂形成術と結石摘除を同時に施行した1例
    小林 憲市, 前田 航規, 鄭 裕午, 城 文泰, 永澤 誠之, 和田 晃典, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 滋賀医学 37 151 -152 2015年03月 [無し][無し]
  • 内藤 泰行, 山田 恭弘, 藤原 敦子, 沖原 宏治, 三木 恒治, 河内 明宏 臨床泌尿器科 69 (2) 169 -173 2015年02月 [無し][無し]
     
    非触知精巣症例に対して腹腔鏡検査を施行し,精巣無発生と判断されれば検査を終了する。腹腔内精巣で低位であれば引き続き腹腔鏡下精巣固定術を,高位であれば二期的Fowler-Stephens法を選択している。腹腔内に精巣が確認されず,内鼠径輪に向かって精管と貧弱な精巣血管が走行する場合には,鼠径部や外性器部に切開を加えることなく,腹腔側から鼠径管内を検索し,遺残精巣(testicular nubbin)を摘出する。今回,非触知精巣に対する腹腔鏡下手術について,広く行われている手技を紹介するとともに,1992年より当科で独自に立てたストラテジーに従い施行してきた腹腔鏡下遺残精巣摘除術についても紹介する。(著者抄録)
  • 上仁 数義, 小林 憲市, 河内 明宏, 内藤 泰行 臨床泌尿器科 69 (2) 186 -191 2015年02月 [無し][無し]
     
    腎盂尿管移行部狭窄症,精索静脈瘤,非触知停留精巣,異所性尿管,性分化疾患の5つの異なる小児泌尿器科疾患に対して,7つの異なる単孔式腹腔鏡手術(laparoendoscopic single-site surgery:LESS)を小児に施行した。LESSは,臍ポートに5mm軟性腹腔鏡,5mm屈曲鉗子,エナジーデバイスを挿入し,必要に応じて,アシスト用の2〜5mmのポートを追加した。全症例で術後経過は良好で,合併症は認めず,輸血を要した症例や,開放手術や腹腔鏡下手術への移行例はなかった。全症例で整容性はきわめて優れていた。LESSが開放手術,腹腔鏡下手術と成績が同等であれば,美容面でLESSが最も優れていると考えられた。(著者抄録)
  • 小児および成人における急性陰嚢症の診断と治療
    上仁 数義, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 岡本 圭生, 成田 充弘, 河内 明宏 日本腹部救急医学会雑誌 35 (2) 335 -335 2015年02月 [無し][無し]
  • Tatsuhiro Yoshiki, Tatsuhiro Yoshiki, Hideaki Iwaki, Ken Ichi Kobayashi, Susumu Kageyama, Hiromi Ii, Akihiro Kawauchi Vesicoureteral Reflux and Pyelonephritis: Risk Factors, Prevalence and Treatment Approaches 85 -92 2015年01月 [無し][無し]
     
    © 2015 Nova Science Publishers, Inc. Aim: Uroplakins (UPs) are urothelium-specific transmembrane proteins consisting of the following four families: Uroplakin Ia (UPIa), uroplakin Ib (UPIb), uroplakin II (UPII), and uroplakin III (UPIII). Vesicoureteral reflux (VUR) is the most common congenital urinary tract anomaly. This disease can pose a major threat to the kidneys as twenty percent of patients with endstage renal disease are reported to have VUR. Although genetic studies for uroplakins (UPs) using mouse have been reported recently, no study has focused on UP genes expression in VUR patients. We describe here the up-regulation of UPs mRNA in exfoliated urinary cells from primary VUR patients. Methods: A real-time RT-PCR for UPs mRNA was performed on exfoliated urothelial cells from primary VUR and control samples. UPs mRNA copies were calculated for each sample. The statistical differences were assessed by the Mann-Whitney U test. Receiver operator characteristic curves were constructed for analysis of the diagnostic values. Results: In the tissues, UPs gene expressions were significantly up-regulated in VUR samples relative to controls. Considering our results, all of the UP gene expressions were up-regulated in the VUR tissues. Moreover, UPs mRNA was found to be up-regulated to a greater extent in VUR than in control exfoliated urinary cells. In evaluating the measurement of urinary UPs mRNA as a screening test for VUR, the sensitivity and the specificity could be determined by the best diagnostic cutoff point. Discussion: Regarding UPs mRNA in VUR, two studies of UPII and UPIII gene knockout mouse models were reported. All of the unaffected UP transcripts were shown by Northern blotting to be up-regulated. Though these studies were in mice, the findings are compatible with our results in humans. Our studies may have less impact because the control subjects were not age-matched. However, we submit that UPs and our results can lead to clarifying the etiology of VUR in the future. Further studies are needed of samples obtained from age-adjusted pediatric patients with other urological conditions, such as cystitis, pyelonephritis, and congenital hydronephrosis. We also investigated by a (99m) technetium dimercaptosuccinic acid renal scan the relationship between UP mRNA expression and the degree of renal scarring in VUR tissue samples. Although not significant, higher expression levels were found for UP mRNAs with the increasing degree of renal scarring. These results show the feasibility of quantitative measurements for urinary UP mRNAs and the potential use in screening for VUR. In addition, our preliminary studies of RT-PCR for tissue UP mRNAs can be useful in elucidating the underlying mechanisms leading to VUR in the future. Conclusions: We submit that the quantitative measurement of urinary Ups mRNA has a potential of developing into the first non-invasive screening test for VUR.
  • 【冷静な対処ができる看護師になろう!泌尿器科患者の急変・危険サイン】 術後の急変・危険サイン(2)
    瀧本 啓太, 成田 充弘, 河内 明宏 泌尿器ケア 20 (1) 21 -26 2015年01月 [無し][無し]
  • 前立腺癌治療と性機能 前立腺癌に対するアンドロゲン除去療法後の勃起障害に関する検討
    邵 仁哲, 沖原 宏治, 針貝 俊治, 内藤 泰行, 納谷 佳男, 鴨井 和美, 三木 恒治, 兼光 紀幸, 落合 厚, 藤原 光文, 河内 明宏 日本性機能学会雑誌 29 (3) 259 -259 2014年12月 [無し][無し]
  • LOH症候群患者におけるクロスオーバー法を用いたエナント酸テストステロン注射薬単独療法とエナント酸テストステロン注射薬およびテストステロン軟膏の組み合わせ療法の臨床比較試験
    針貝 俊治, 内藤 泰行, 納谷 佳男, 鴨井 和美, 三木 恒治, 邵 仁哲, 兼光 紀幸, 落合 厚, 藤原 光文, 河内 明宏 日本性機能学会雑誌 29 (3) 260 -260 2014年12月 [無し][無し]
  • 腎部分切除 無阻血腹腔鏡下腎部分切除術の経験
    吉田 哲也, 河内 明宏, 成田 充弘, 影山 進, 本郷 文弥, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 6 (2) 42 -42 2014年12月 [無し][無し]
  • Fumiya Hongo, Akihiro Kawauchi, Takashi Ueda, Atsuko Fujihara, Yasuyuki Naitoh, Terukazu Nakamura, Yoshio Naya, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki INTERNATIONAL JOURNAL OF UROLOGY 21 (11) 1093 -1096 2014年11月 [無し][無し]
     
    ObjectivesTo investigate the long-term outcomes of hand-assisted laparoscopic radical nephrectomy compared with those of open nephrectomy. MethodsHand-assisted laparoscopic radical nephrectomy was carried out in 132 patients with T1 renal cell carcinoma (between November 1999 and November 2008). Their outcomes were compared with those of 61 patients treated with open nephrectomy. The durations of follow up were 6-121 months (median 65 months) and 7-146 months (median 84 months) in the hand-assisted laparoscopic radical nephrectomy and open nephrectomy groups, respectively. ResultsThe 7-year recurrence-free rates were 88.5 and 85.6% in the hand-assisted laparoscopic radical nephrectomy and open nephrectomy groups, respectively, showing no significant difference between the two groups. The 7-year cancer-specific survival rates were 92.3 and 91.4% in the hand-assisted laparoscopic radical nephrectomy and open nephrectomy groups, respectively, showing no significant difference between the two groups. Also, the 10-year recurrence-free rates were 85.4 and 78.1% in the hand-assisted laparoscopic radical nephrectomy and open nephrectomy groups, respectively. When changes in the recurrence-free rate were analyzed using the Kaplan-Meier method, no significant difference was observed between the two groups. The 10-year cancer-specific survival rates were 91.8 and 87.9% for hand-assisted laparoscopic radical nephrectomy and open nephrectomy, respectively, showing no significant difference between the groups. ConclusionsHand-assisted laparoscopic radical nephrectomy might be comparable with open nephrectomy with regard to long-term cancer control.
  • 単孔式腹腔鏡下腎盂形成術
    河内 明宏, 上仁 数義, 小林 憲市, 内藤 泰行 Urology Today 21 (4) 189 -192 2014年11月 [無し][無し]
  • 小児泌尿器科における腹腔鏡手術
    河内 明宏 Japanese Journal of Endourology 27 (3) 98 -98 2014年11月 [無し][無し]
  • 内藤 泰行, 山田 恭弘, 藤原 敦子, 本郷 文哉, 沖原 宏治, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 27 (3) 137 -137 2014年11月 [無し][無し]
  • 上仁 数義, 永澤 誠之, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 27 (3) 212 -212 2014年11月 [無し][無し]
  • 瀧本 啓太, 小林 憲市, 城 文泰, 鄭 裕午, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 27 (3) 213 -213 2014年11月 [無し][無し]
  • 小児に対する単孔式手術用ポートを使用した腹腔鏡下腎尿管摘除の経験
    小林 憲市, 永澤 誠之, 和田 晃典, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 和義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 27 (3) 228 -228 2014年11月 [無し][無し]
  • 吉田 哲也, 永澤 誠之, 和田 晃典, 小林 憲市, 水流 輝彦, 瀧本 啓太, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 Japanese Journal of Endourology 27 (3) 236 -236 2014年11月 [無し][無し]
  • 成田 充弘, 影山 進, 吉田 哲也, 瀧本 啓太, 水流 輝彦, 和田 晃典, 永澤 誠之, 草場 拓人, 長船 崇, 河内 明宏 Japanese Journal of Endourology 27 (3) 241 -241 2014年11月 [無し][無し]
  • VIO電極を用いた腹腔鏡下無阻血腎部分切除術の有用性の検討
    本郷 文弥, 河内 明宏, 内藤 泰行, 納谷 佳男, 鴨井 和実, 増田 健人, 伊藤 吉三, 宮下 浩明, 沖原 宏治, 三木 恒治 Japanese Journal of Endourology 27 (3) 267 -267 2014年11月 [無し][無し]
  • 水流 輝彦, 成田 充弘, 城 文泰, 鄭 裕午, 広田 竜一, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 河内 明宏 Japanese Journal of Endourology 27 (3) 318 -318 2014年11月 [無し][無し]
  • 副腎性Cushing症候群とPAを合併したGAD抗体陽性糖尿病の1例
    大村 寧, 福山 佳代, 小橋 修平, 小山 哲朗, 山川 勇, 渋谷 和之, 小河 秀郎, 山田 衆, 板橋 健太郎, 濱中 訓生, 窪田 成寿, 金 哲將, 青木 治亮, 河内 明宏, 大村 昌夫 日本内分泌学会雑誌 90 (3) 966 -966 2014年10月 [無し][無し]
  • 精索静脈瘤に対する顕微鏡下低位結紮術導入初期におけるinguinal、subinguinal approachの比較検討
    富田 圭司, 吉田 哲也, 影山 進, 河内 明宏 日本生殖医学会雑誌 59 (4) 412 -412 2014年10月 [無し][無し]
  • COX-2阻害薬は膀胱原発inflammatory myofibroblastic tumorの膀胱温存手術に寄与する(Neoadjuvant treatment with COX-2 inhibitor allows bladder-conserving surgery in IMT of the bladder)
    都間 佑介, 大内 一孝, 宮地 充, 土屋 邦彦, 家原 知子, 内藤 泰行, 河内 明宏, 三木 恒治, 小西 英一, 柳澤 昭夫, 細井 創 日本小児血液・がん学会雑誌 51 (4) 352 -352 2014年10月 [無し][無し]
  • 泌尿器領域の単孔・Reduced Port Surgery 適応、教育と将来展望 単孔式腹腔鏡下腎盂形成術は、標準術式になりうるか? 開放腎盂形成術、腹腔鏡下腎盂形成術との比較検討
    上仁 数義, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 19 (7) 391 -391 2014年10月 [無し][無し]
  • 小児泌尿器疾患に対する単孔式腹腔鏡手術
    内藤 泰行, 山田 恭弘, 藤原 敦子, 本郷 文弥, 鴨井 和実, 沖原 宏治, 三木 恒治, 河内 明宏 日本内視鏡外科学会雑誌 19 (7) 542 -542 2014年10月 [無し][無し]
  • 腹腔鏡下無阻血腎部分切除術の適応決定におけるR.E.N.A.L Nephrometry scoreの有用性の検討
    本郷 文弥, 河内 明宏, 藤原 敦子, 中西 弘之, 内藤 泰行, 中村 晃和, 納谷 佳男, 鴨井 和実, 伊藤 吉三, 宮下 浩明, 沖原 宏治, 三木 恒治 日本内視鏡外科学会雑誌 19 (7) 677 -677 2014年10月 [無し][無し]
  • 当院におけるロボット支援腹腔鏡下腎部分切除術の初期経験
    吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本内視鏡外科学会雑誌 19 (7) 853 -853 2014年10月 [無し][無し]
  • 腎癌に対して腎部分切除施行21年後に乳房内転移を来たした1例
    荘子 万可, 鳥山 清二郎, 本郷 文弥, 中村 雄一, 野村 武史, 上田 崇, 大石 正勝, 中村 晃和, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 泌尿器科紀要 60 (9) 459 -459 2014年09月 [無し][無し]
  • 偽性尿管瘤の1例
    山下 寛人, 上仁 数義, 広田 竜一, 城 文泰, 鄭 裕午, 藤原 遼, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充弘, 岡本 圭生, 荒木 勇雄, 河内 明宏 泌尿器科紀要 60 (9) 460 -460 2014年09月 [無し][無し]
  • 動脈硬化指標と過活動膀胱との関連についての検討 滋賀動脈硬化疫学研究(SESSA)より
    水流 輝彦, 荒木 勇雄, 門脇 沙也佳, 久松 隆史, 藤吉 朗, 河内 明宏, 三浦 克之, 上島 弘嗣 日本排尿機能学会誌 25 (1) 153 -153 2014年09月 [無し][無し]
  • 女性骨盤臓器脱がQOLに与える影響 TVM手術前後のP-QOLを用いた検討
    前田 航規, 荒木 勇雄, 水流 輝彦, 鄭 裕午, 広田 竜一, 馬塲 雅人, 吉田 哲也, 河内 明宏 日本排尿機能学会誌 25 (1) 169 -169 2014年09月 [無し][無し]
  • 過活動膀胱に対するフェソテロジンの効果発現時期に関する検討
    伊狩 亮, 荒木 勇雄, 水流 輝彦, 前澤 卓也, 坂野 祐司, 河内 明宏 日本排尿機能学会誌 25 (1) 188 -188 2014年09月 [無し][無し]
  • 内藤 泰行, 山田 恭弘, 藤原 敦子, 沖原 宏治, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 27 (2) 299 -302 2014年09月 [無し][無し]
     
    昨今小児泌尿器科領域においても、腹腔鏡手術が普及しつつある。当科においても膀胱尿管逆流症に対しての腹腔鏡下手術として、Lich-Gregoir法とCohen法を行ってきた。経膀胱アプローチによるCohen法は2005年より施行し、現在までに100例を超える症例を経験した。経膀胱アプローチの小児症例の長期成績として成功率は96%、手術時間は片側症例で144分、両側症例で208分であった。2例に吻合部狭窄がみられた。鎮痛剤の使用は平均1回、術後3-4日で退院した。具体的な手術方法とこれまでに施した手技上の工夫、そして応用可能な手術についても概説する。(著者抄録)
  • Cyclin D1bトランスジェニックマウスの直腸腫瘍発生におけるAkt活性化の関与(Activation of Akt contributes to the rectal tumorigenesis in cyclin D1b transgenic mice)
    金 哲將, 旦部 幸博, 向所 賢一, 杉原 洋行, 河内 明宏, 井上 寛一 日本癌学会総会記事 73回 P -2027 2014年09月 [無し][無し]
  • 野田哲史, 佐村和紀, 大塚凌, 堀江美弥, 平大樹, 藤原遼, 河内明宏, 生城真一, 榊利之, 森田真也, 寺田智祐 日本医療薬学会年会講演要旨集 24th 227 2014年08月 [無し][無し]
  • 画像で科学する性機能 勃起のMRI画像
    邵 仁哲, 針貝 俊治, 中井 隆介, 藤井 秀岳, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 29 (2) 123 -123 2014年08月 [無し][無し]
  • LOH症候群に対するテストステロン軟膏の用量差による有効性の変化の検討
    兼光 紀幸, 邵 仁哲, 針貝 俊治, 落合 厚, 内藤 泰行, 納谷 佳男, 藤原 光文, 河内 明宏, 三木 恒治 日本性機能学会雑誌 29 (2) 194 -194 2014年08月 [無し][無し]
  • 【神経診察-そのポイントと次の一手】 自律神経系 排尿障害 診察の進め方と評価
    水流 輝彦, 荒木 勇雄, 河内 明宏 Medicina 51 (7) 1282 -1285 2014年07月 [無し][無し]
     
    <ポイント>下部尿路症状は(1)蓄尿症状,(2)排尿症状,(3)排尿後症状に大別される.下部尿路症状は神経疾患が原因のこともあるが,ほかの併存疾患の鑑別が必要である.尿排出障害の存在の確認に残尿測定が有用である.国際前立腺症状スコア,過活動膀胱症状質問票,排尿日誌は症状の評価に有用である.(著者抄録)
  • 転移性腎癌に対するスニチニブ療法の治療経験
    吉田 哲也, 馬塲 雅人, 影山 進, 成田 充弘, 河内 明宏, 新井 豊, 金 哲將, 坂野 祐司, 長船 崇, 長谷 行洋 腎癌研究会会報 (44) 57 -57 2014年07月 [無し][無し]
  • 去勢抵抗性前立腺癌に対する低用量ドセタキセル療法の臨床的検討
    瀧本 啓太, 城 文泰, 鄭 裕午, 広田 竜一, 藤原 遼, 山下 寛人, 小林 憲市, 水流 輝彦, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 荒木 勇雄, 河内 明宏 泌尿器科紀要 60 (7) 338 -338 2014年07月 [無し][無し]
  • 前立腺小細胞癌の7例
    藤原 遼, 影山 進, 山下 寛人, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 成田 充弘, 岡本 圭生, 荒木 勇雄, 河内 明宏 泌尿器科紀要 60 (7) 341 -341 2014年07月 [無し][無し]
  • 増大傾向を示した小児陰茎包皮色素性母斑の1例
    小林 憲市, 上仁 数義, 城 文泰, 広田 竜一, 鄭 裕午, 藤原 遼, 山下 寛人, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 成田 充弘, 荒木 勇雄, 河内 明宏 泌尿器科紀要 60 (7) 342 -342 2014年07月 [無し][無し]
  • 河内 明宏, 上仁 数義, 小林 憲市, 内藤 泰行 泌尿器外科 27 (6) 935 -939 2014年06月 [無し][無し]
     
    膀胱尿管逆流および巨大尿管症に対する腹腔鏡手術として、腹腔鏡下膀胱内手術(膀胱内到達法)が保険適応になっている。この術式の中でCohen法の術式とポイントを概説する。(著者抄録)
  • 【患者さんへの説明にそのまま使える!泌尿器科手術のすべて】 (第1章)腎臓の手術 腎尿管全摘除術
    影山 進, 吉田 哲也, 河内 明宏 泌尿器ケア (2014夏季増刊) 37 -44 2014年06月 [無し][無し]
  • 漢方薬治療が有効であった成人夜尿症の1例
    上仁 数義, 小林 憲市, 河内 明宏 日本夜尿症学会学術集会プログラム・抄録集 25回 29 -29 2014年06月 [無し][無し]
  • 毎晩2回以上の夜尿症例に対するDDAVP、アラーム療法の長期成績
    内藤 泰行, 山田 恭弘, 藤原 敦子, 三木 恒治, 小林 憲市, 上仁 数義, 河内 明宏 日本夜尿症学会学術集会プログラム・抄録集 25回 38 -38 2014年06月 [無し][無し]
  • 癌と性機能 進行性精巣腫瘍における神経温存後腹膜リンパ節廓清
    中村 晃和, 上田 崇, 大石 正勝, 本郷 文弥, 納谷 佳男, 河内 明宏, 三木 恒治 日本性機能学会雑誌 29 (1) 45 -45 2014年06月 [無し][無し]
  • 小林 憲市, 鄭 裕午, 城 文泰, 藤原 遼, 永澤 誠之, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 河内 明宏 日本小児泌尿器科学会雑誌 23 (2) 170 -170 2014年06月 [無し][無し]
  • 内藤 泰行, 山田 恭弘, 藤原 敦子, 本郷 文弥, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本小児泌尿器科学会雑誌 23 (2) 196 -196 2014年06月 [無し][無し]
  • 上仁 数義, 鄭 裕午, 藤原 遼, 永澤 誠之, 佐野 太一, 小林 憲市, 河内 明宏 日本小児泌尿器科学会雑誌 23 (2) 200 -200 2014年06月 [無し][無し]
  • 佐野 太一, 上仁 数義, 藤原 遼, 永澤 誠之, 小林 憲市, 河内 明宏 日本小児泌尿器科学会雑誌 23 (2) 214 -214 2014年06月 [無し][無し]
  • 当院および関連病院における転移性腎癌に対するスニチニブの使用経験
    馬場 雅人, 吉田 哲也, 影山 進, 河内 明宏, 新井 豊, 金 哲將, 坂野 祐司, 長船 崇, 長谷 行洋 日本癌治療学会誌 49 (3) 1787 -1787 2014年06月 [無し][無し]
  • 滋賀医科大学における前立腺癌ヨウ素125密封小線源療法のリスク別治療成績
    岡本 圭生, 河野 直明, 柳 勇也, 野間 和夫, 村田 喜代史, 河内 明宏 日本癌治療学会誌 49 (3) 2251 -2251 2014年06月 [無し][無し]
  • 腎癌に対する凍結療法の初期治療経験
    本郷 文弥, 納谷 佳男, 大石 正勝, 上田 崇, 中村 晃和, 鴨井 和実, 河内 明宏, 田中 治, 山田 恵, 三木 恒治 泌尿器外科 27 (別冊号) 104 -106 2014年05月 [無し][無し]
     
    腎癌に対する凍結療法の初期治療について検討した。活動性重複癌や合併症によって全身麻酔下での根治的手術が適応外あるいは単腎によって手術を希望しなかった10例を対象とした。スライドベッド上で腹臥位とし、局所麻酔下でCTガイド下に直径1.5mm径のプローブを腫瘍に穿刺し治療を行った。治療効果はmRE-CISTで判定した。3ヵ月後の評価にてCR(造影効果の消失)は3例、PRは7例であった。また、合併症については1例で後出血を認めた。また、治療後に腎機能の増悪は認めなかった。
  • 河内 明宏, 上仁 数義, 小林 憲市, 内藤 泰行 小児外科 46 (5) 470 -474 2014年05月 [無し][無し]
  • 腎癌に対する凍結療法の経験
    安食 淳, 上田 崇, 加藤 峰之, 塩田 晃司, 堀田 俊介, 内藤 泰行, 中村 晃和, 本郷 文弥, 鴨井 和実, 河内 明宏, 三木 恒治 泌尿器科紀要 60 (5) 253 -253 2014年05月 [無し][無し]
  • 自然破裂に対する塞栓術が不十分であった腎血管筋脂肪腫に対し、腹腔鏡下腎部分切除術を施行した1例
    萩原 暢久, 木村 泰典, 乾 将吾, 本田 俊一朗, 藤原 敦子, 岩田 健, 納谷 佳男, 邵 仁哲, 沖原 宏治, 河内 明宏, 三木 恒治 泌尿器科紀要 60 (5) 254 -254 2014年05月 [無し][無し]
  • Yasuyuki Naitoh, Akihiro Kawauchi, Yasuhiro Yamada, Atsuko Fujihara, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 191 (4) E954 -E955 2014年04月 [無し][無し]
  • 腎部分切除 無阻血腹腔鏡下腎部分切除術の経験
    河内 明宏, 成田 充弘, 影山 進, 吉田 哲也, 本郷 文弥, 三木 恒治 泌尿器外科 27 (4) 508 -508 2014年04月 [無し][無し]
  • 幼児期に発症した精巣捻転の1例
    小林 憲市, 上仁 数義, 松本 富美, 島田 憲次, 河内 明宏 日本小児科学会雑誌 118 (4) 735 -735 2014年04月 [無し][無し]
  • LOH症候群患者におけるクロスオーバー法を用いたエナント酸テストステロン注射薬単独療法とエナント酸テストステロン注射薬およびテストステロン軟膏の組み合わせ療法の臨床比較試験
    針貝 俊二, 邵 仁哲, 兼光 紀幸, 落合 厚, 内藤 泰行, 納谷 佳男, 鴨井 和美, 藤原 光文, 河内 明宏, 三木 恒治 日本生殖医学会雑誌 59 (1-2) 70 -71 2014年04月 [無し][無し]
  • PET検査の評価に苦慮した後腹膜原発セミノーマの1例
    加藤 峰之, 中村 晃和, 塩田 晃司, 堀田 俊介, 上田 崇, 内藤 泰行, 納谷 佳男, 鴨井 和実, 河内 明宏, 三木 恒治 泌尿器科紀要 60 (4) 197 -197 2014年04月 [無し][無し]
  • 副腎癌との鑑別が困難であった後腹膜原発神経鞘腫の1例
    本田 俊一朗, 藤原 敦子, 乾 将吾, 木村 泰典, 岩田 健, 本郷 文弥, 邵 仁哲, 沖原 宏治, 河内 明宏, 三木 恒治 泌尿器科紀要 60 (4) 198 -198 2014年04月 [無し][無し]
  • 大林 聡子, 坂井 智行, 中原 小百合, 澤井 俊宏, 増田 俊樹, 小林 憲市, 上仁 数義, 河内 明宏 日本小児腎臓病学会雑誌 27 (1Suppl.) 178 -178 2014年04月 [無し][無し]
  • 小林 憲市, 上仁 数義, 城 文泰, 藤原 遼, 坂井 智行, 澤井 俊宏, 河内 明宏 日本小児腎臓病学会雑誌 27 (1Suppl.) 185 -185 2014年04月 [無し][無し]
  • 小児泌尿器科疾患 成人期への持越し(Transition)症例 単孔式腹腔鏡下腎盂形成術
    河内 明宏, 内藤 泰行, 上仁 数義, 小林 憲市, 吉田 哲也, 瀧本 啓太, 山田 恭弘, 沖原 宏治, 三木 恒治 日本泌尿器科学会総会 102回 295 -295 2014年04月 [無し][無し]
  • 単孔式ないしはリデュースポートサージェリー 安全性と整容性の両立 腎盂尿管移行部狭窄症 総合病院からスタートする立場
    河内 明宏, 内藤 泰行, 上仁 数義, 小林 憲市, 成田 充弘, 影山 進, 山田 恭弘, 三木 恒治 日本泌尿器科学会総会 102回 325 -325 2014年04月 [無し][無し]
  • 当科における経膀胱腹腔鏡下逆流防止術の経験
    山田 恭弘, 内藤 泰行, 藤原 敦子, 本郷 文弥, 鴨井 和実, 河内 明宏, 三木 恒治 日本泌尿器科学会総会 102回 402 -402 2014年04月 [無し][無し]
  • ソフト凝固を用いた腹腔鏡下無阻血腎部分切除術の経験
    吉田 哲也, 城 文泰, 鄭 裕午, 広田 竜二, 山下 寛人, 小林 憲市, 水流 輝彦, 瀧本 啓太, 影山 進, 上仁 数義, 成田 充弘, 荒木 勇雄, 河内 明宏 日本泌尿器科学会総会 102回 404 -404 2014年04月 [無し][無し]
  • 新規癌関連タンパク質C7orf24を標的とした去勢抵抗性前立腺癌治療の開発
    花田 英紀, 影山 進, 荒木 勇雄, 河内 明宏, 飯居 宏美, 吉貴 達寛 日本泌尿器科学会総会 102回 413 -413 2014年04月 [無し][無し]
  • 高齢男性における過活動膀胱と動脈硬化指標との関係 滋賀動脈硬化疫学研究から
    水流 輝彦, 荒木 勇雄, 河内 明宏, 門脇 紗也佳, 久松 隆史, 藤吉 朗, 三浦 克之, 上島 弘嗣 日本泌尿器科学会総会 102回 423 -423 2014年04月 [無し][無し]
  • 小児泌尿器疾患に対する単孔式腹腔鏡手術
    内藤 泰行, 河内 明宏, 山田 恭弘, 小林 憲市, 藤原 敦子, 上仁 数義, 本郷 文弥, 鴨井 和実, 三木 恒治 日本泌尿器科学会総会 102回 436 -436 2014年04月 [無し][無し]
  • 膀胱癌細胞に対して細胞浸潤促進活性を有するcyclin D1b variantのoncogenic potentialの検討
    金 哲將, 旦部 幸博, 河内 明宏, 井上 寛一 日本泌尿器科学会総会 102回 464 -464 2014年04月 [無し][無し]
  • 滋賀医科大学における前立腺癌ヨウ素125密封小線源療法のリスク別治療成績
    岡本 圭生, 河野 直明, 柳 勇也, 野間 和夫, 橋本 恵輔, 村田 喜代史, 岡田 裕作, 河内 明宏 日本泌尿器科学会総会 102回 482 -482 2014年04月 [無し][無し]
  • TVM手術による骨盤臓器脱(POP)患者の下部尿路症状(LUTS)の変化
    馬塲 雅人, 荒木 勇雄, 城 文泰, 鄭 裕午, 藤原 遼, 山下 寛人, 草場 拓人, 窪田 成寿, 水流 輝彦, 前澤 卓也, 吉田 哲也, 河内 明宏 日本泌尿器科学会総会 102回 491 -491 2014年04月 [無し][無し]
  • ロボット支援腹腔鏡下前立腺全摘除術の初期成績 3名術者による導入
    成田 充弘, 影山 進, 吉田 哲也, 瀧本 啓太, 水流 輝彦, 山下 寛人, 藤原 遼, 城 文泰, 鄭 裕午, 広田 竜一, 河内 明宏 日本泌尿器科学会総会 102回 494 -494 2014年04月 [無し][無し]
  • 腹腔鏡下無阻血腎部分切除術の適応決定におけるR.E.N.A.L Nephrometry scoreの有用性
    本郷 文弥, 河内 明宏, 上田 崇, 内藤 泰行, 納谷 佳男, 鴨井 和実, 伊藤 吉三, 宮下 浩明, 三木 恒治 日本泌尿器科学会総会 102回 504 -504 2014年04月 [無し][無し]
  • 多部位立体26ヶ所前立腺針生検の検討
    藤原 遼, 影山 進, 山下 寛人, 小林 憲市, 水流 輝彦, 瀧本 啓太, 吉田 哲也, 上仁 数義, 成田 充宏, 岡本 圭生, 荒木 勇雄, 河内 明宏 日本泌尿器科学会総会 102回 535 -535 2014年04月 [無し][無し]
  • Overnight urinary drainageは、膀胱機能障害患者の夜間の膀胱過伸展を改善し、上部尿路障害や尿路感染を予防する
    上仁 数義, 山下 寛人, 小林 憲市, 荒木 勇雄, 河内 明宏, 兼松 明弘, 今村 正明 日本泌尿器科学会総会 102回 545 -545 2014年04月 [無し][無し]
  • 排尿筋収縮不全患者に対するαブロッカー、ジスチグミン、ベタネコール併用療法の効果
    瀧本 啓太, 荒木 勇雄, 藤原 遼, 馬場 雅人, 水流 輝彦, 河内 明宏 日本泌尿器科学会総会 102回 546 -546 2014年04月 [無し][無し]
  • 低位の停留精巣に対する陰嚢アプローチによる精巣固定術の臨床的検討
    小林 憲市, 上仁 数義, 吉田 哲也, 影山 進, 成田 充弘, 河内 明宏 日本泌尿器科学会総会 102回 549 -549 2014年04月 [無し][無し]
  • 再発予防目的THP導入膀注療法におけるTUR直後注入併用の意義
    影山 進, 金 哲將, 吉田 哲也, 馬塲 雅人, 山下 寛人, 富田 圭司, 水流 輝彦, 花田 英紀, 上仁 数義, 成田 充弘, 岡本 圭生, 荒木 勇雄, 河内 明宏 日本泌尿器科学会総会 102回 583 -583 2014年04月 [無し][無し]
  • 精索静脈瘤に対する顕微鏡下低位結紮術導入初期におけるinguinal、subinguinal approachの比較検討
    富田 圭司, 藤原 遼, 馬塲 雅人, 山下 寛人, 水流 輝彦, 花田 英紀, 吉田 哲也, 影山 進, 上仁 数義, 成田 充弘, 岡本 圭生, 荒木 勇雄, 河内 明宏 日本泌尿器科学会総会 102回 646 -646 2014年04月 [無し][無し]
  • 当科における高齢者に対するBCG膀胱内注入療法の検討
    納谷 佳男, 三神 一哉, 大石 正勝, 上田 崇, 木村 泰典, 中村 晃和, 本郷 文弥, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 22 (1) 59 -60 2014年04月 [無し][無し]
  • 腎癌治療と腎機能 腹腔鏡下腎部分切除術と腎機能 JSE多施設共同研究1,375例の解析
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 政嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一, 腹腔鏡下腎部分切除術の治療成績に関する研究班 日本腎泌尿器疾患予防医学研究会誌 22 (1) 26 -28 2014年04月 [無し][無し]
     
    JSE多施設共同研究より得られた腹腔鏡下腎部分切除術(LPN)1375例の解析結果から、手術治療介入による腎機能の経過について検討した。その結果、手術の介入によりeGFRは術後1ヵ月で12%低下したが、その後1年間はほぼ不変であった。年齢別にみると、60歳未満群は60歳以上群に比べ術前の腎機能が良好で、術後3ヵ月、1年における腎機能の回復も良好であった。CKD stage別にみると、stage I、IIでは術後腎機能の改善傾向を認めたが、stage III以降では術後進行性に腎機能の低下を認めた。
  • 河内 明宏, 上仁 数義, 小林 憲市, 内藤 泰行, 三木 恒治 小児外科 46 (3) 286 -289 2014年03月 [無し][無し]
  • 前立腺がんの診断・治療の最新トピックス
    岡田 裕作, 成田 充弘, 岡本 圭生, 河内 明宏, 河野 直明, 邵 啓全, 村田 喜代史 滋賀医学 36 2 -5 2014年03月 [無し][無し]
  • 滋賀医科大学におけるロボット支援腹腔鏡下前立腺全摘除術の導入と初期経験
    影山 進, 成田 充弘, 吉田 哲也, 城 文泰, 鄭 裕午, 広田 竜一, 藤原 遼, 山下 寛人, 小林 憲市, 水流 輝彦, 瀧本 啓太, 上仁 数義, 岡本 圭生, 荒木 勇雄, 河内 明宏 滋賀医学 36 127 -127 2014年03月 [無し][無し]
  • Koki Maeda, Fumiyoshi Kojima, Mitsuaki Ishida, Muneo Iwai, Akiko Kagotani, Akihiro Kawauchi International Journal of Clinical and Experimental Pathology 7 (7) 4408 -4414 2014年 [無し][無し]
     
    Müllerianosis of the urinary bladder is an extremely rare benign condition, characterized by the presence of a mixture of at least two müllerian-derived components, and endosalpingiosis is also an extremely rare condition, characterized by the presence of tubal-type epithelium. In this report, we describe the 17th case of müllerianosis and 5th case of endosalpingiosis of the urinary bladder. A 39-year-old Japanese female presented with menstrual hematuria and was found to have a polypoid lesion in the posterior wall of the urinary bladder. Histopathological study demonstrated variably-sized dilated tubular glands in the lamina propria and muscularis propria. These dilated glands were covered by ciliated cuboidal cells, and some of them were covered by columnar cells with intracytoplasmic mucin. Moreover, a tiny focus of endometrial tissues was also present. Immunohistochemically, these glandular cells were positive for estrogen receptor. Accordingly, a diagnosis of müllerianosis was made. The second case was a 37-year-old Japanese female, who was found to have a polypoid lesion in the posterior wall of the bladder. Dilated tubular glands were covered by ciliated cells in the lamina propria and muscularis propria. Neither endocervical nor endometrial tissues were observed. Immunohistochemically, these ciliated cells were positive for estrogen receptor. Accordingly, a diagnosis of endosalpingiosis was made. Our analysis revealed that these two conditions mainly affect premenopausal females and occur exclusively in the posterior wall. Although the pathogenesis remains completely unresolved, a metaplastic theory is favored. The recognition of these two conditions is important because they can mimic invasive adenocarcinoma.
  • 肝浸潤を伴う副腎原発悪性リンパ腫の1例
    乾 将吾, 本郷 文弥, 木村 泰典, 岩田 健, 納谷 佳男, 鴨井 和実, 河内 明宏, 三木 恒治, 落合 登志哉 泌尿器科紀要 59 (12) 804 -804 2013年12月 [無し][無し]
  • 高い前立腺がん検診暴露率を有する地域で見つかる前立腺癌の特徴
    北村 浩二, 篠田 康夫, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 21 (2) 169 -171 2013年12月 [無し][無し]
     
    京都府乙訓地区では1995年より継続して前立腺がん検診を行っており、18年間で一次検診のべ受診者は81,971人に達し、最終的に前立腺癌706人を検出した(検出率0.9%)。検診を継続して行うといわゆるステージシフトが起こりより多くの早期癌が見つかり、その結果、治療成績も良好になった。日本泌尿器科学会発刊『前立腺癌診療ガイドライン』に記載されているPSA監視療法の選択基準とされるGleasonスコア6以下、陽性コア2本以下(陽性コアでの腫瘍占拠割合50%以下)で、PSA 10ng/ml以下、臨床病期T2以下の症例は、初期では10%以下であったが、その後徐々に増加し近年では30%を超えることもあり、2012年では48%とほぼ半数を占めていた。一方、初期治療は初期ではホルモン療法が主な治療法であったがその後徐々に減少し、近年では手術療法もやや減少する傾向にあり、かわりにPSA監視療法が顕著に増加し2012年では40%近くを占め、さまざまな治療方法の中で最も多い選択肢となった。PSA検査が普及すると低リスクの限局性前立腺癌が増加し、良好な治療成績を示すようになる。一方、前立腺には潜在癌(ラテント癌)が少なからず発生し、検診で発見された前立腺癌の中にも高分化かつ小病巣の前立腺癌が含まれ過剰診断・過剰治療が懸念されるが、検診(PSA)暴露率が高くなればなるほどその懸念が強くなった。過剰治療に対してはPSA監視療法の導入でひとつの解決方法が示されているが、過剰診断に対してはさまざまなPSA関連マーカーやMRIなどの画像診断でも確実な解決方法は示されていない。今後の研究成果が期待される。(著者抄録)
  • 腎部分切除 無阻血腹腔鏡下腎部分切除術の経験
    河内 明宏, 成田 充弘, 影山 進, 吉田 哲也, 本郷 文弥, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 5 (2) 60 -60 2013年12月 [無し][無し]
  • 河内 明宏, 上仁 数義, 小林 憲市, 内藤 泰行 臨床泌尿器科 67 (12) 959 -964 2013年11月 [無し][無し]
     
    小児泌尿器科領域の腹腔鏡下手術としては,腹腔鏡下精巣固定術,腹腔鏡下精巣摘除術,腹腔鏡下腎摘除術,腹腔鏡下腎盂形成術,腹腔鏡下膀胱内手術(膀胱尿管逆流,巨大尿管症)が保険適応になっている。これらの手術の術式とポイントを概説する。(著者抄録)
  • 河内 明宏, 上仁 数義, 小林 憲市 外来小児科 16 (3) 327 -331 2013年11月 [無し][無し]
  • 河内 明宏, 上仁 数義, 小林 憲市 外来小児科 16 (3) 339 -341 2013年11月 [無し][無し]
  • 当科における高齢者に対するBCG膀胱内注入療法の検討
    納谷 佳男, 三神 一哉, 大石 正勝, 上田 崇, 木村 泰典, 中村 晃和, 本郷 文弥, 河内 明宏, 三木 恒治 日本老年泌尿器科学会誌 26 77 -77 2013年11月 [無し][無し]
  • LESSは従来の腹腔鏡手術よりも低侵襲か? 小児泌尿器科疾患に対するLESSの成績
    内藤 泰行, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 26 (3) 163 -163 2013年11月 [無し][無し]
  • 後世に伝えたい匠の技2 経膀胱的腹腔鏡下手術における技と工夫
    内藤 泰行, 河内 明宏, 邵 仁哲, 鴨井 和実, 三木 恒治 Japanese Journal of Endourology 26 (3) 186 -186 2013年11月 [無し][無し]
  • 後世に伝えたい匠の技3 腹腔鏡手術における止血の工夫 ネオベールとボルヒールによるカバー
    本郷 文弥, 河内 明宏, 内藤 泰行, 中村 晃和, 納谷 佳男, 鴨井 和実, 沖原 宏治, 三木 恒治 Japanese Journal of Endourology 26 (3) 194 -194 2013年11月 [無し][無し]
  • 後世に伝えたい匠の技4 腹腔鏡下腎部分切除術におけるキドニーグラスパーによる部分阻血法の試み
    本郷 文弥, 河内 明宏, 長嶋 隆夫, 伊藤 吉三, 内藤 泰行, 中村 晃和, 納谷 佳男, 三木 恒治 Japanese Journal of Endourology 26 (3) 197 -197 2013年11月 [無し][無し]
  • 腎盂形成術の腹腔鏡プログラム 小児に対する腹腔鏡下腎盂形成術 単孔式も含めて
    河内 明宏, 内藤 泰行, 沖原 宏治, 宮下 浩明, 三神 一哉, 伊藤 吉三, 増田 健人, 三木 恒治 Japanese Journal of Endourology 26 (3) 211 -211 2013年11月 [無し][無し]
  • 河内 明宏, 内藤 泰行, 山田 恭弘, 上仁 数義, 小林 憲市, 三木 恒治 Japanese Journal of Endourology 26 (3) 214 -214 2013年11月 [無し][無し]
  • 尿路系子宮内膜症に対する腹腔鏡下手術の経験
    上田 崇, 藤原 敦子, 内藤 泰行, 納谷 佳男, 本郷 文弥, 鴨井 和実, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 26 (3) 239 -239 2013年11月 [無し][無し]
  • 伊藤 明宏, 岩村 正嗣, 繁田 正信, 田邉 一成, 松田 公志, 内藤 誠二, 寺地 敏郎, 河内 明宏, 中川 健, 荒井 陽一, LPN共同研究グループ Japanese Journal of Endourology 26 (3) 260 -260 2013年11月 [無し][無し]
  • 腎癌に対する腹腔鏡下腎部分切除術のエビデンスを問う 腹腔鏡下腎部分切除術における阻血の影響
    河内 明宏, 本郷 文弥, 内藤 泰行, 納谷 佳男, 中村 晃和, 沖原 宏治, 宮下 浩明, 伊藤 吉三, 増田 健人, 三木 恒治 日本内視鏡外科学会雑誌 18 (7) 290 -290 2013年11月 [無し][無し]
  • 泌尿器単孔式手術の現状と将来 泌尿器単孔式手術の現状と将来
    河内 明宏, 内藤 泰行, 本郷 文弥, 宮下 浩明, 伊藤 吉三, 増田 健人, 三木 恒治 日本内視鏡外科学会雑誌 18 (7) 332 -332 2013年11月 [無し][無し]
  • 当科で行っている経膀胱的腹腔鏡下手術
    内藤 泰行, 河内 明宏, 邵 仁哲, 本郷 文弥, 鴨井 和実, 三木 恒治 日本内視鏡外科学会雑誌 18 (7) 495 -495 2013年11月 [無し][無し]
  • 小径腎癌に対する腹腔鏡下腎部分切除術における部分温阻血法の試み
    本郷 文弥, 長嶋 隆夫, 藤井 秀岳, 内藤 泰行, 中村 晃和, 納谷 佳男, 鴨井 和実, 河内 明宏, 三木 恒治 日本内視鏡外科学会雑誌 18 (7) 759 -759 2013年11月 [無し][無し]
  • 【最新臨床睡眠学-睡眠障害の基礎と臨床-】 睡眠時随伴症群 その他の睡眠時随伴症 夜尿症
    河内 明宏, 内藤 泰行, 三木 恒治 日本臨床 71 (増刊5 最新臨床睡眠学) 456 -460 2013年10月 [無し][無し]
  • 【最新臨床睡眠学-睡眠障害の基礎と臨床-】 各科領域・疾患における睡眠障害 泌尿器科疾患(夜間頻尿、過活動膀胱)
    藤原 敦子, 河内 明宏 日本臨床 71 (増刊5 最新臨床睡眠学) 625 -631 2013年10月 [無し][無し]
  • PAX2はアンドロゲン非依存性前立腺がん細胞においてAR遺伝子の発現を促進する(PAX2 up-regulates androgen receptor gene expression in an androgen-independent prostate cancer cell line)
    伊藤 紗弥, 上田 崇, 木村 泰典, 岩田 健, 本郷 文弥, 沖原 宏治, 鴨井 和実, 河内 明宏, 三木 恒治 日本癌学会総会記事 72回 272 -272 2013年10月 [無し][無し]
  • PSF1の発現は前立腺癌の悪性度に相関する(Correlation of PSF1 expression with malignancy of prostate cancer)
    田原 秀一, 内藤 尚道, 黄瀬 一義, 鴨井 和実, 沖原 宏治, 河内 明宏, 森井 英一, 野々村 祝夫, 柳澤 昭夫, 三木 恒治, 高倉 伸幸 日本癌学会総会記事 72回 429 -429 2013年10月 [無し][無し]
  • 前立腺癌転移におけるPAX2の機能解析(Hyper-expression of PAX2 in human metastatic prostate tumors and its promoter activity by an in vitro invasion model)
    上田 崇, 伊藤 紗弥, 上野 彰久, 中河 秀生, 大石 正勝, 中村 晃和, 納谷 佳男, 本郷 文弥, 河内 明宏, 三木 恒治 日本癌学会総会記事 72回 432 -432 2013年10月 [無し][無し]
  • Takashi Ueda, Saya Ito, Takumi Shiraishi, Prakash Kulkarni, Akihisa Ueno, Hideo Nakagawa, Yasunori Kimura, Fumiya Hongo, Kazumi Kamoi, Akihiro Kawauchi, Tsuneharu Miki Prostate 73 (13) 1403 -1412 2013年09月 [無し][無し]
     
    BACKGROUND Metastasis is a consequence of many biological events, during which cancer stem cells are shifted into a malignant state. Among these events, invasion of prostate cancer cells into host tissues is possible to be assessed by means of an in vitro invasion model, and is thought to be coupled to altered expression of membrane proteins. Dysregulated functions of the factors regulating organogenesis during embryogenesis are known to facilitate metastasis of many types of cancers. PAX2 (paired box 2) is a member of the PAX transcription factor family, which regulates prostatic ductal growth and branching in organogenesis of mammalian prostates. However, the role of PAX2 in prostate cancer development remains to be determined. METHODS PAX2 expression in human prostate cancers and normal prostate epithelium were examined by quantitative RT-PCR and immunohistochemistry. Matrigel invasion assay and a gene array analysis were performed using prostate cancer cell lines transfected with either control or PAX2 siRNA. RESULTS In human prostate cancers, PAX2 was hyper-expressed in metastatic cancers, but was expressed at lower levels in non-metastatic cancers. Consistent with this, PAX2 knockdown repressed cell growth and invasion in a Matrigel invasion assay. Gene ontology analysis revealed that many cell membrane proteins were downregulated after PAX2 knockdown. CONCLUSIONS Our data suggested that PAX2 hyper-expression promotes the development of the metastatic state in prostate cancer cells, presumably through upregulating the expression of cell membrane proteins. Prostate 73: 1403-1412, 2013. © 2013 Wiley Periodicals, Inc. Copyright © 2013 Wiley Periodicals, Inc.
  • 腎癌骨転移に対するデノスマブの初期治療経験(5例)
    堀田 俊介, 上田 崇, 木村 泰典, 中村 晃和, 納谷 佳男, 本郷 文弥, 河内 明宏, 三木 恒治 泌尿器科紀要 59 (9) 624 -624 2013年09月 [無し][無し]
  • 脾腎静脈シャントを伴う腎癌に対して腹腔鏡下腎摘除術を行った1例
    本田 俊一朗, 本郷 文弥, 木村 泰典, 塩田 晃司, 堀田 俊介, 上田 崇, 藤原 敦子, 内藤 泰行, 邵 仁哲, 河内 明宏, 三木 恒治 泌尿器科紀要 59 (9) 631 -631 2013年09月 [無し][無し]
  • 河内 明宏, 内藤 泰行, 山田 恭弘, 三木 恒治 Japanese Journal of Endourology 26 (2) 228 -230 2013年09月 [無し][無し]
  • 腎癌薬物治療の最前線 腎癌薬物治療にて患者QOLも考えた最適なTKI、mTOR阻害剤の使用法と次世代腎癌治療への展望を考える 分子標的治療における遺伝子多型の検討と新規ワクチンIMA901
    本郷 文弥, 大石 正勝, 上田 崇, 中村 晃和, 納谷 佳男, 河内 明宏, 三木 恒治 日本癌治療学会誌 48 (3) 716 -716 2013年09月 [無し][無し]
  • 前立腺がん治療の最前線 前立腺癌に対するFocal Therapy
    鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本癌治療学会誌 48 (3) 726 -726 2013年09月 [無し][無し]
  • 当科における初回後腹膜リンパ節郭清の臨床的検討
    中村 晃和, 木村 泰典, 上田 崇, 大石 正勝, 本郷 文弥, 納谷 佳男, 河内 明宏, 三木 恒治 日本癌治療学会誌 48 (3) 1144 -1144 2013年09月 [無し][無し]
  • 進行性腎癌に対して一次治療としてのTKI投与後の二次治療の検討
    本郷 文弥, 大石 正勝, 上田 崇, 中村 晃和, 納谷 佳男, 三神 一哉, 伊藤 吉三, 河内 明宏, 三木 恒治 日本癌治療学会誌 48 (3) 1186 -1186 2013年09月 [無し][無し]
  • 3D recurrent cancer mappingを用いた外照射再発症例に対する救済密封小線源療法
    沖原 宏治, 小林 加奈, 鴨井 和実, 岩田 健, 内藤 泰行, 河内 明宏, 山田 恵, 三木 恒治 日本癌治療学会誌 48 (3) 1490 -1490 2013年09月 [無し][無し]
  • 光力学的診断(PDD)とNarrow Band Imaging(NBI)を併用したTURBtについての検討
    納谷 佳男, 大石 正勝, 上田 崇, 木村 泰典, 中村 晃和, 本郷 文弥, 河内 明宏, 三木 恒治 日本癌治療学会誌 48 (3) 1625 -1625 2013年09月 [無し][無し]
  • 術後の機能保持を目指した小切開前立腺全摘除術の検討
    鴨井 和実, 沖原 宏治, 岩田 健, 上田 崇, 河内 明宏, 三木 恒治 日本癌治療学会誌 48 (3) 2066 -2066 2013年09月 [無し][無し]
  • H. Honjo, Y. Naya, M. Nakao, J. Ueyama, T. Kondo, M. Nakanishi, O. Ukimura, A. Kawauchi, T. Miki NEUROUROLOGY AND URODYNAMICS 研究発表ペーパー・要旨(国際会議) 32 (6) 692 -693 2013年08月 [無し][無し]
  • Yasunori Kimura, Terukazu Nakamura, Akihiro Kawauchi, Gaku Kawabata, Fumiya Hongo, Tsuneharu Miki International Journal of Urology 20 (8) 837 -841 2013年08月 [無し][無し]
     
    We report our experience of extraperitoneal nerve-sparing laparoscopic retroperitoneal lymph node dissection after chemotherapy. Six patients were diagnosed with non-seminomatous germ cell tumor after orchiectomy and clinical stage IIB disease. Nerve-sparing laparoscopic retroperitoneal lymph node dissection was carried out for residual retroperitoneal tumors after cisplatin-based chemotherapy. The median tumor diameter was 2.95cm before chemotherapy and 1.95cm after chemotherapy. A modified left (n=1), right (n=1) and bilateral (n=4) template for the dissection area was used. Surgery was successfully completed in all patients and no conversion to open surgery was necessary. Median operative time was 394min (range 212-526min). Median blood loss was 75mL (range 10-238mL). The overall complication rate was 33.3% (2/6). Two patients had prolonged lymphatic leakage (gradeI), which was managed conservatively. Antegrade ejaculation was preserved in all six patients. The histopathological findings showed that two patients had mature teratoma and four patients had necrotic tissue. After a median follow up of 30months (range 24-36), no recurrence of disease was observed. We can conclude that extraperitoneal nerve-sparing laparoscopic retroperitoneal lymph node dissection for residual tumors after chemotherapy is a feasible operation. The oncological outcomes need to be confirmed in a certain number of patients with longer follow up. © 2013 The Japanese Urological Association.
  • Soroush Rais-Bahrami, Emad R. Rizkala, Jeffrey A. Cadeddu, Volkan Tugcu, Ithaar H. Derweesh, Aly M. Abdel-Karim, Akihiro Kawauchi, Arvin K. George, Riccardo Autorino, Aditya Bagrodia, Erkan Sonmezay, Salah Elsalmy, Michael A. Liss, Brian M. Harrow, Jihad H. Kaouk, Lee Richstone, Robert J. Stein Urology 82 (2) 366 -372 2013年08月 [無し][無し]
     
    Objective: To report an international, multi-institutional series of laparoendoscopic single-site pyeloplasty (LESS-P) with analysis of functional outcomes. Materials and Methods: LESS-P cases performed between October 2007 and June 2012 at 7 institutions worldwide per individual institutional protocols, entry criteria, and techniques were included. Patient characteristics, operative indications, perioperative outcomes, and postoperative follow-up were retrospectively collected and analyzed. Results: The study included 140 adult patients (age 39.9 ± 15.7 years body mass index 24.8 ± 4.2 kg/m2 15% with previous abdominal surgery) who underwent unilateral LESS-P, most of whom (94.3%) had dismembered reconstructions. Mean operative time was 202.1 ± 47 minutes with an estimated blood loss of 61.2 ± 44.6 mL. Robotic laparoendoscopic single-site surgery was applied in 31 patients (22.1%). A single 2-3 mm accessory port was used in 44 patients (31.4%) and a single 5-12 mm accessory port was added in 9 patients (6.4%), whereas 10 patients (7.1%) were converted to conventional multiport laparoscopy. No patients required conversion to open surgery, nor were any intraoperative complications reported. Length of hospitalization was 2.4 ± 1.6 days. The overall 90-day postoperative complication rate was 18.6%, mostly low-grade complications (Clavien I-II). With a mean follow-up of 14.0 ± 10.8 months, 93.4% had resolution of symptoms and 94.4% had radiographic evidence demonstrating resolution of ureteropelvic junction obstruction. Assessment of drainage with diuretic nuclear renal scan provided evidence of improvement in 86.5% of patients on their first postoperative renal scan. Conclusion: This study highlights the most comprehensive experience with LESS-P reported to date. Outcome measures parallel those of large published series of conventional laparoscopic pyeloplasty. Despite these encouraging findings, longer follow-up is needed to determine the efficacy and durability of this approach for the treatment of ureteropelvic junction obstruction. © 2013 Elsevier Inc. All Rights Reserved.
  • 腹腔鏡下腎部分切除術の経験と最近の手技
    本郷 文弥, 河内 明宏, 三神 一哉, 伊藤 吉三, 内藤 泰行, 邵 仁哲, 納谷 佳男, 鴨井 和実, 三木 恒治 泌尿器外科 26 (別冊号) 54 -55 2013年07月 [無し][無し]
  • 高い前立腺がん検診暴露率を有する地域で見つかる前立腺がんの特徴
    北村 浩二, 篠田 康夫, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 21 (1) 76 -76 2013年07月 [無し][無し]
  • 腎癌に対する凍結療法の初期治療経験
    本郷 文弥, 納谷 佳男, 大石 正勝, 上田 崇, 中村 晃和, 鴨井 和実, 河内 明宏, 田中 治, 山田 恵, 三木 恒治 腎癌研究会会報 (43) 61 -61 2013年07月 [無し][無し]
  • 【高齢者の排尿機能障害】 前立腺肥大症による排尿機能障害と薬物治療
    河内 明宏 日本老年医学会雑誌 50 (4) 440 -444 2013年07月 [無し][無し]
  • 術後の機能保持を目指した小切開前立腺全摘除術(第3報) 筋膜温存術は術後勃起機能に貢献するか?
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 上田 崇, 河内 明宏, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 5 (1) 69 -72 2013年07月 [無し][無し]
     
    筋膜温存もしくは非温存前立腺全摘除術症例のうち神経血管束温存手術を行った37症例について、術後尿禁制とともに勃起機能の回復について調査した。その結果外科的断端陽性率を悪化させずに腫瘍の解剖学的位置や進展度から片側、両側の筋膜温存手技を使い分けることが可能であり、片側温存でも良好な尿禁制の回復が得られた。両側の神経温存と筋膜温存を行った場合には良好な勃起機能の改善が期待できると考えられた。(著者抄録)
  • Noriyuki Kanemitsu, Jintetsu Soh, Yasuyuki Naitoh, Atsushi Ochiai, Yoshio Naya, Kazumi Kamoi, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF SEXUAL MEDICINE 研究発表ペーパー・要旨(国際会議) 10 246 -246 2013年06月 [無し][無し]
  • 夜尿症と睡眠
    河内 明宏, 内藤 泰行, 三木 恒治 日本小児泌尿器科学会雑誌 22 (1) 22 -24 2013年06月 [無し][無し]
     
    夜尿は睡眠時に起こる症状のため、夜尿と睡眠は密接な関係がある。夜尿の基礎疾患には患者の睡眠に影響を及ぼすことにより夜尿の原因となるものがある。最近、夜尿症患者の睡眠状態が正常者よりわるく、その睡眠状態はむしろ浅いとする報告が見られる。夜間尿量に関して夜尿症患者において正常者より多いと報告されている。ただ、正常者に睡眠前に多量の水分を摂取させると、尿意覚醒をするあるいは多量の蓄尿をして朝まで持つということが判明し、夜尿を防止する機構であると考えられた。膀胱容量に関しては昼間の膀胱容量は夜尿症患者と正常者では差はないが、睡眠時の膀胱容量は夜尿症患者で少ないと考えられた。(著者抄録)
  • 小児泌尿器科領域の腹腔鏡手術経膀胱アプローチ
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 22 (1) 28 -31 2013年06月 [無し][無し]
     
    昨今小児泌尿器科領域においても、急速に腹腔鏡手術が普及しつつある。当科においてもVURに対する体腔鏡下逆流防止術はLich-Gregoir法とCohen法によるを行なってきた。経膀胱アプローチによるCohen法は、2005年より施行し、現在までに100例を超える症例を経験した。今回、この経膀胱アプローチの具体的な方法と工夫、そして応用可能な手術について概説する。(著者抄録)
  • Nocturnal polyuriaに対するDDAVPとアラーム療法の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 24回 74 -75 2013年06月 [無し][無し]
  • 小児泌尿器科腹腔鏡手術のトピックス 小児泌尿器科領域の腹腔鏡ルーチン手術の状況 技術認定に向けて(腎・上部尿路)
    内藤 泰行, 河内 明宏, 三木 恒治 日本小児泌尿器科学会雑誌 22 (2) 202 -202 2013年06月 [無し][無し]
  • Hideo Saito, Tadashi Matsuda, Kazunari Tanabe, Akihiro Kawauchi, Toshiro Terachi, Ken Nakagawa, Masatsugu Iwamura, Masanobu Shigeta, Seiji Naito, Akihiro Ito, Yoichi Arai JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 31 (15) 2013年05月 [無し][無し]
  • LOH症候群とAndrogen補充療法 LOH症候群とアンドロゲン補充療法の問題点
    邵 仁哲, 関 英雄, 針貝 俊二, 兼光 紀幸, 落合 厚, 内藤 泰行, 納谷 佳男, 鴨井 和美, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 28 (1) 61 -61 2013年05月 [無し][無し]
  • 小児尿道脱の2例
    福井 彩子, 内藤 泰行, 井上 裕太, 粥川 成優, 岩田 健, 邵 仁哲, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 泌尿器科紀要 59 (5) 321 -321 2013年05月 [無し][無し]
  • シスチン結石に対し尿管切石術を行った1例
    加藤 峰之, 内藤 泰行, 粥川 成優, 藤原 敦子, 邵 仁哲, 納谷 佳男, 河内 明宏, 三木 恒治 泌尿器科紀要 59 (5) 327 -327 2013年05月 [無し][無し]
  • Hisashi Honjo, Yoshio Naya, Masahiro Nakao, Jun Ueyama, Takaaki Kondo, Mamoru Nakanishi, Akihiro Kawauchi, Hiroshi Kitakoji, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 189 (4) E799 -E799 2013年04月 [無し][無し]
  • Natsuki Takaha, Yoshihiro Sowa, Ichiro Takeuchi, Takashi Ueda, Saya Ito-Ueda, Yasunori Kimura, Tsuyoshi Iwata, Terukazu Nakamura, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 189 (4) E85 -E85 2013年04月 [無し][無し]
  • Jintetsu Soh, Noriyuki Kanemitsu, Yoshio Naya, Yasuyuki Naitoh, Atsushi Ochiai, Kazumi Kamoi, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 189 (4) E505 -E505 2013年04月 [無し][無し]
  • 【後期研修医がおさえておきたい泌尿器疾患TOP 30】 疾患 夜尿症
    内藤 泰行, 河内 明宏, 三木 恒治 泌尿器外科 26 (特別号) 312 -318 2013年04月 [無し][無し]
  • 腎・膀胱・前立腺・その他 術後の機能保持を目指した小切開前立腺全摘除術(第3報) 筋膜温存術は術後勃起機能に貢献するか?
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 上田 崇, 河内 明宏, 三木 恒治 泌尿器外科 26 (4) 509 -509 2013年04月 [無し][無し]
  • 【泌尿器科診療ベストNAVI】 疾患・病態の診療 先天性疾患および小児泌尿器科疾患 尿管の先天異常 尿管瘤
    河内 明宏 臨床泌尿器科 67 (4) 88 -90 2013年04月 [無し][無し]
  • 【泌尿器科診療ベストNAVI】 疾患・病態の診療 先天性疾患および小児泌尿器科疾患 尿管の先天異常 巨大尿管症
    河内 明宏 臨床泌尿器科 67 (4) 91 -92 2013年04月 [無し][無し]
  • 【泌尿器疾患に対する単孔式腹腔鏡手術】 小児泌尿器疾患に対する単孔式腹腔鏡手術
    矢野 公大, 内藤 泰行, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 26 (1) 51 -53 2013年04月 [無し][無し]
  • High risk精巣腫瘍の治療戦略 再発・難治性精巣腫瘍に対する治療戦略
    中村 晃和, 木村 泰典, 上田 崇, 納谷 佳男, 本郷 文弥, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 134 -134 2013年03月 [無し][無し]
  • 前立腺癌を効率的に診断するためのMRI-US Fusion Biopsy
    鴨井 和実, 沖原 宏治, 岩田 健, 本郷 文弥, 納谷 佳男, 上田 崇, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 208 -208 2013年03月 [無し][無し]
  • 尿中NOx値と血清NOx値を用いた過活動膀胱症状の病態評価の検討 住民検診受診者を対象として
    本城 久司, 納谷 佳男, 中尾 昌宏, 上山 純, 近藤 高明, 市野 直浩, 中西 守, 河内 明宏, 北小路 博司, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 213 -213 2013年03月 [無し][無し]
  • 小切開前立腺全摘除術における筋膜温存術の検討 術後尿失禁に対する影響
    上野 彰久, 鴨井 和実, 沖原 宏治, 岩田 健, 上田 崇, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 263 -263 2013年03月 [無し][無し]
  • 尿細胞診クラスIII以上の尿路上皮癌症例に対する上部尿路細胞診の意義
    納谷 佳男, 三神 一哉, 大石 正勝, 上田 崇, 木村 泰典, 中村 晃和, 邵 仁哲, 本郷 文弥, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 291 -291 2013年03月 [無し][無し]
  • Laparoendoscopic Single Site Surgery(LESS)の経験
    篠田 康夫, 河内 明宏, 内藤 泰行, 邵 仁哲, 伊藤 吉三, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 302 -302 2013年03月 [無し][無し]
  • 腹腔鏡下腎部分切除術における腎部分阻血の試み
    藤井 秀岳, 本郷 文弥, 松ヶ角 透, 内藤 泰行, 邵 仁哲, 納谷 佳男, 鴨井 和実, 伊藤 吉三, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 302 -302 2013年03月 [無し][無し]
  • 重複腎盂尿管・巨大尿管症例に対する経膀胱的腹腔鏡手術
    内藤 泰行, 河内 明宏, 大石 正勝, 邵 仁哲, 本郷 文弥, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 304 -304 2013年03月 [無し][無し]
  • 高齢去勢抵抗性前立腺癌患者に対するドセタキセルの適正投与量に関する検討 SIOG基準に基づいた後ろ向き検討
    高羽 夏樹, 沖原 宏治, 岩田 健, 本郷 文弥, 鴨井 和実, 河内 明宏, 南口 尚紀, 伊藤 吉三, 米田 公彦, 大嶺 卓司, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 307 -307 2013年03月 [無し][無し]
  • 無阻血、無縫合腹腔鏡下腎部分切除術の経験
    河内 明宏, 本郷 文弥, 内藤 泰行, 邵 仁哲, 宮下 浩明, 伊藤 吉三, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 311 -311 2013年03月 [無し][無し]
  • 当院における進行性腎細胞癌に対するエベロリムス25例の臨床的検討
    大石 正勝, 本郷 文弥, 上田 崇, 木村 泰典, 中村 晃和, 納谷 佳男, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 321 -321 2013年03月 [無し][無し]
  • 救済化学療法施行時の予後予測分類IGCCC at salvageの実臨床における妥当性の検討
    藤原 敦子, 中村 晃和, 木村 泰典, 上田 崇, 納谷 佳男, 本郷 文弥, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 326 -326 2013年03月 [無し][無し]
  • CDDP分割投与レジメンにおけるアプレピタント至適投与法の検討
    山田 剛司, 中村 晃和, 本郷 文弥, 納谷 佳男, 木村 泰典, 上田 崇, 藤井 秀岳, 大石 正勝, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 326 -326 2013年03月 [無し][無し]
  • 前立腺Anterior fibromuscular stromaが特異的機能を持つ可能性
    岩田 健, 浮村 理, 河田 光博, 藤原 敦子, 沖原 宏治, 鴨井 和実, 本城 久司, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 327 -327 2013年03月 [無し][無し]
  • 腹腔鏡下腎部分切除術150例の検討
    本郷 文弥, 河内 明宏, 内藤 泰行, 邵 仁哲, 納谷 佳男, 鴨井 和実, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 363 -363 2013年03月 [無し][無し]
  • 当院における単孔式腹腔鏡下手術(LaparoEndoscopic Singleport Surgery:LESS)の経験
    松原 弘樹, 松ヶ角 透, 中河 秀生, 石田 博万, 平原 直樹, 伊藤 吉三, 河内 明宏 日本泌尿器科学会雑誌 104 (2) 366 -366 2013年03月 [無し][無し]
  • 進行性腎細胞癌に対するアキシチニブの初期治療経験
    上田 崇, 福井 彩子, 大石 正勝, 木村 泰典, 中村 晃和, 納谷 佳男, 本郷 文弥, 邵 仁哲, 三神 一哉, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 379 -379 2013年03月 [無し][無し]
  • アンドロゲン非依存性前立腺がんにおいてPAX2はAR遺伝子の発現を亢進する
    伊藤 紗弥, 上田 崇, 木村 泰典, 岩田 健, 本郷 文弥, 沖原 宏治, 鴨井 和実, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 415 -415 2013年03月 [無し][無し]
  • ヒト転移性前立腺がんにおけるPPAの高発現と生体外浸潤モデルによるそのプロモータ活性(Hyper-expression of PPA in human metastatic prostate tumors and its promoter activity by an in vitro invasion model)
    上田 崇, 伊藤 紗弥, 大石 正勝, 木村 泰典, 中村 晃和, 納谷 佳男, 本郷 文弥, 邵 仁哲, 三神 一哉, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 417 -417 2013年03月 [無し][無し]
  • 羊膜を基質とし作成した口腔粘膜再生シートを用いた尿路再建
    内藤 泰行, 河内 明宏, 邵 仁哲, 本郷 文弥, 鴨井 和実, 沖原 宏治, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 465 -465 2013年03月 [無し][無し]
  • アンドロゲン受容体転写抑制による精巣腫瘍発生分子機構の解析
    中河 秀生, 上田 崇, 上田 紗弥, 大石 正勝, 中村 晃和, 納谷 佳男, 本郷 文弥, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 470 -470 2013年03月 [無し][無し]
  • LOH症候群を合併した2型糖尿病患者に対するテストステロン値と臨床症状に関する検討
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 針貝 俊治, 内藤 泰行, 鴨井 和実, 河内 明宏, 藤原 光文, 三木 恒治 日本泌尿器科学会雑誌 104 (2) 472 -472 2013年03月 [無し][無し]
  • 17年間の検診発見前立腺がんにおける生検陽性コア数と初期治療の検討
    北村 浩二, 篠田 康夫, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 21 (1) 79 -80 2013年03月 [無し][無し]
  • T1a腎癌に対する腎部分切除術のoncological outcome 日本泌尿器内視鏡学会多施設共同研究の結果より
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 政嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一, 腹腔鏡下腎部分切除術の治療成績に関する研究班 日本腎泌尿器疾患予防医学研究会誌 21 (1) 88 -89 2013年03月 [無し][無し]
  • 前立腺癌のアンドロゲン除去療法における勃起障害の発症率とPDE5阻害薬の有効性に関する検討
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 針貝 俊治, 内藤 泰行, 鴨井 和実, 河内 明宏, 藤原 光文, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 21 (1) 112 -113 2013年03月 [無し][無し]
  • Mitsuaki Ishida, Ryo Fujiwara, Keiji Tomita, Tetsuya Yoshida, Muneo Iwai, Keiko Yoshida, Akiko Kagotani, Akihiro Kawauchi, Hidetoshi Okabe International Journal of Clinical and Experimental Pathology 速報,短報,研究ノート等(学術雑誌) 6 (11) 2640 -2643 2013年 [無し][無し]
  • 【BPHの診療ガイドライン】 BPHの診断 泌尿器科医に求められるレベル
    河内 明宏, 三木 恒治 排尿障害プラクティス 20 (4) 281 -285 2012年12月 [無し][無し]
     
    泌尿器科専門医を対象とした新しい『前立腺肥大症診療ガイドライン』において、診断に関しては、前立腺肥大症を想定した場合に必ず行うべき評価(基本評価)と症例を選択して行う評価(選択評価)、その他の評価に分類された。基本評価としては、病歴聴取、症状・QOL評価、身体所見、尿検査、尿流測定、残尿測定、前立腺超音波検査、血清PSA測定が挙げられた。選択評価としては、排尿記録、内圧尿流検査、血清クレアチニン値測定、上部尿路超音波検査などが挙げられた。(著者抄録)
  • 【前立腺肥大症の診療最前線-薬物療法を中心に-】 総論 前立腺肥大症の診断
    河内 明宏, 三木 恒治 Modern Physician 32 (12) 1443 -1447 2012年12月 [無し][無し]
     
    <ポイント>●前立腺肥大症診療ガイドラインが改訂、発行された。●診断に関しては基本評価と選択評価に分類された。●基本評価としては病歴聴取、症状・QOL評価、身体所見、尿検査、尿流測定、残尿測定、前立腺超音波検査、血清PSA測定が挙げられた。●選択評価としては排尿記録、内圧尿流検査、血清クレアチニン値測定、上部尿路超音波検査などが挙げられる。(著者抄録)
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    内藤 泰行, 河内 明宏, 邵 仁哲, 本郷 文弥, 鴨井 和実, 三木 恒治 日本内視鏡外科学会雑誌 17 (7) 393 -393 2012年12月 [無し][無し]
  • キドニーグラスパーを用いた腹腔鏡下腎部分切除術の経験
    本郷 文弥, 河内 明宏, 内藤 泰行, 邵 仁哲, 納谷 佳男, 三木 恒治 日本内視鏡外科学会雑誌 17 (7) 741 -741 2012年12月 [無し][無し]
  • 神経再生誘導管を用いた勃起神経・下腹神経の再生の試み
    邵 仁哲, 納谷 佳男, 内藤 泰行, 鴨井 和美, 河内 明宏, 三木 恒治, 兼光 紀幸, 問山 大輔, 藤原 光文, 落合 厚 日本性機能学会雑誌 27 (3) 276 -276 2012年12月 [無し][無し]
  • 腎・膀胱・前立腺・その他 術後の機能保持を目指した小切開前立腺全摘除術(第3報) 筋膜温存術は術後勃起機能に貢献するか?
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 上田 崇, 河内 明宏, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 4 (2) 38 -38 2012年12月 [無し][無し]
  • LESSの普及と標準化 次に何が必要か? 単孔式腹腔鏡下腎盂形成術
    河内 明宏, 内藤 泰行, 宮下 浩明, 伊藤 吉三, 増田 健人, 三木 恒治 Japanese Journal of Endourology 25 (3) 134 -134 2012年11月 [無し][無し]
  • 単孔式腹腔鏡下副腎摘除術
    河内 明宏, 内藤 泰行, 金沢 元洪, 邵 仁哲, 三木 恒治 Japanese Journal of Endourology 25 (3) 163 -163 2012年11月 [無し][無し]
  • キドニーグラスパーを用いた腹腔鏡下腎部分切除術の経験
    本郷 文弥, 河内 明宏, 平山 きふ, 長嶋 隆夫, 内藤 泰行, 邵 仁哲, 納谷 佳男, 鴨井 和実, 伊達 成基, 三木 恒治 Japanese Journal of Endourology 25 (3) 199 -199 2012年11月 [無し][無し]
  • 単孔式腹腔鏡下腎盂形成術と腎結石摘出術を同時に施行した3例
    内藤 泰行, 河内 明宏, 邵 仁哲, 本郷 文弥, 鴨井 和実, 三木 恒治 Japanese Journal of Endourology 25 (3) 206 -206 2012年11月 [無し][無し]
  • 腹腔鏡下尿管膀胱子宮内膜症手術の経験
    藤原 敦子, 河内 明宏, 本郷 文弥, 邵 仁哲, 三木 恒治 Japanese Journal of Endourology 25 (3) 211 -211 2012年11月 [無し][無し]
  • 上部尿路癌に対する腹腔鏡下リンパ節廓清術についての臨床的検討
    篠田 康夫, 大石 正勝, 本郷 文弥, 中村 晃和, 内藤 泰行, 納谷 佳男, 邵 仁哲, 鴨井 和実, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 25 (3) 238 -238 2012年11月 [無し][無し]
  • 重複腎盂尿管症例に対する経膀胱的腹腔鏡手術の検討
    大石 正勝, 内藤 泰行, 邵 仁哲, 本郷 文弥, 鴨井 和実, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 25 (3) 255 -255 2012年11月 [無し][無し]
  • 当院における単孔式腹腔鏡下手術(LaparoEndoscopic Singleport Surgery:LESS)の経験
    松原 弘樹, 松ヶ角 透, 中河 秀生, 石田 博万, 平原 直樹, 伊藤 吉三, 河内 明宏 Japanese Journal of Endourology 25 (3) 307 -307 2012年11月 [無し][無し]
  • 年齢別解析結果を含めた前立腺がん検診における受診者の認識度調査
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  • 排尿機能検査士資格認定制度の現状と問題点 排尿機能検査士に対するアンケート調査から
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  • 80歳以上の高齢者における転移性腎癌に対する分子標的治療
    中河 秀生, 本郷 文弥, 井上 裕太, 上田 崇, 木村 泰典, 中村 晃和, 三神 一哉, 河内 明宏, 三木 恒治 日本老年泌尿器科学会誌 25 94 -94 2012年11月 [無し][無し]
  • 進行性・難治性精巣腫瘍に対するsequential chemotherapyの検討
    中村 晃和, 木村 泰典, 上田 崇, 岩田 健, 藤原 敦子, 三神 一哉, 納谷 佳男, 本郷 文弥, 高羽 夏樹, 河内 明宏, 三木 恒治 日本癌治療学会誌 47 (3) 1054 -1054 2012年10月 [無し][無し]
  • 高齢者去勢抵抗性前立腺癌を対象とした国際老年腫瘍学会治療指針導入に関する検討
    鴨井 和実, 沖原 宏治, 岩田 健, 本郷 文弥, 納谷 佳男, 木村 泰典, 上田 崇, 中村 晃和, 河内 明宏, 三木 恒治 日本癌治療学会誌 47 (3) 1062 -1062 2012年10月 [無し][無し]
  • 上部尿路癌に対する腹腔鏡下リンパ節郭清についての検討
    納谷 佳男, 河内 明宏, 藤井 秀岳, 本郷 文弥, 中村 晃和, 邵 仁哲, 内藤 泰行, 鴨井 和実, 三木 恒治 日本癌治療学会誌 47 (3) 1372 -1372 2012年10月 [無し][無し]
  • 腹腔鏡下腎部分切除術における良性腫瘍予測モデル 多施設共同研究1,375例の解析
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 正嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一 日本癌治療学会誌 47 (3) 1826 -1826 2012年10月 [無し][無し]
  • 単孔式腹腔鏡下根治的腎摘除術の経験
    河内 明宏, 本郷 文弥, 内藤 泰行, 邵 仁哲, 納谷 佳男, 鴨井 和実, 沖原 宏治, 伊藤 吉三, 三木 恒治 日本癌治療学会誌 47 (3) 1854 -1854 2012年10月 [無し][無し]
  • 去勢抵抗性前立腺癌患者における骨関連事象の発生状況
    牛嶋 壮, 鴨井 和実, 矢野 公大, 岩田 健, 沖原 宏治, 河内 明宏, 三木 恒治 日本癌治療学会誌 47 (3) 1904 -1904 2012年10月 [無し][無し]
  • 前立腺癌放射線療法後に発症した膀胱癌の臨床的検討
    三神 一哉, 沖原 宏治, 上田 崇, 木村 泰典, 中村 晃和, 本郷 文弥, 納谷 佳男, 河内 明宏, 小林 加奈, 三木 恒治 日本癌治療学会誌 47 (3) 2623 -2623 2012年10月 [無し][無し]
  • T. Nakamura, Y. Kimura, K. Mikami, T. Ueda, F. Hongo, N. Takaha, A. Kawauchi, T. Miki UROLOGY 研究発表ペーパー・要旨(国際会議) 80 (3) S325 -S326 2012年09月 [無し][無し]
  • Fumiya Hongo, Akihiro Kawauchi, Yasuyuki Naitoh, Jintetsu Soh, Yoshio Naya, Kazumi Kamoi, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 26 A288 -A288 2012年09月 [無し][無し]
  • K. Kamoi, K. Okihara, T. Iwata, A. Kawauchi, T. Miki UROLOGY 研究発表ペーパー・要旨(国際会議) 80 (3) S13 -S13 2012年09月 [無し][無し]
  • Akihiro Kawauchi, Yoshio Naya, Fumiya Hongo, Jintetsu Soh, Yasuyuki Naitoh, Terukazu Nakamura, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 26 A166 -A167 2012年09月 [無し][無し]
  • Kazumi Kamoi, Koji Okihara, Tsuyoshi Iwata, Fumiya Hongo, Yasuyuki Naitoh, Takashi Ueda, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 26 A38 -A38 2012年09月 [無し][無し]
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintestu Soh, Fumiya Hongo, Kazumi Kamoi, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 26 A136 -A136 2012年09月 [無し][無し]
  • 【女性の睡眠障害】 女性の排尿障害と睡眠障害 過活動膀胱も含む
    藤原 敦子, 河内 明宏 睡眠医療 6 (3) 459 -463 2012年09月 [無し][無し]
     
    ・夜間頻尿や夜間尿失禁は睡眠障害の原因となることがあり、特に、夜間頻尿は頻度が高く、患者のQOLを著しく害するため大きな問題である。夜間頻尿には様々な原因があり、過活動膀胱や間質性膀胱炎などの尿路の疾患のほか、夜間多尿が睡眠障害が原因となることもある。診断には、尿検査や問診のほか、排尿記録が有用である。・過活動膀胱は尿意切迫感を主症状とする症状症候群で、治療は抗コリン薬の投与を中心とした薬物療法が第一選択である。・間質性膀胱炎は原因不明の膀胱の慢性炎症性疾患で、典型的には蓄尿時の膀胱痛を特徴とし、麻酔下の膀胱水圧拡張術が有効であることがある。・夜間多尿は高血圧や薬剤性などを含め、様々な原因が混在しているために治療困難なことも多いが、水分摂取量の適正化などの生活指導が重要である。夜間頻尿診療ガイドラインの診療アルゴリズムを参考にした診断治療が望ましい。(著者抄録)
  • 悪性黒色腫の副腎転移に対し腹腔鏡下副腎摘除術を施行した1例
    井上 裕太, 本郷 文弥, 福井 彩子, 粥川 成優, 藤原 敦子, 内藤 泰行, 三神 一哉, 高羽 夏樹, 河内 明宏, 三木 恒治 泌尿器科紀要 58 (9) 532 -532 2012年09月 [無し][無し]
  • Sexual medicineの進化 科学はいかに社会と文化を変えたか 性機能障害のリスクの探求と得られた果実
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 鴨井 和実, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 27 (2) 155 -155 2012年09月 [無し][無し]
  • 神経再生誘導管を用いた勃起神経・下腹神経の再生の試み
    兼光 紀幸, 邵 仁哲, 問山 大輔, 納谷 佳男, 落合 厚, 内藤 泰行, 鴨井 和実, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 27 (2) 170 -170 2012年09月 [無し][無し]
  • 【腎癌診療をめぐる最近の話題】 腹腔鏡下手術における最近の進歩
    河内 明宏, 本郷 文弥, 三木 恒治 Pharma Medica 30 (8) 41 -44 2012年08月 [無し][無し]
  • 抗コリン剤不応性OAB患者に対するミラベグロンの有効性の検討
    藤原 敦子, 岩田 健, 鴨井 和実, 河内 明宏, 三木 恒治 日本排尿機能学会誌 23 (1) 257 -257 2012年08月 [無し][無し]
  • 前立腺癌細胞におけるアンドロゲン非依存性細胞生存とドセタキセル抵抗性に関するHMGA1の関連(Association of HMGA1 with androgen-independent cell survival and docetaxel-resistance in prostate cancer cells)
    高羽 夏樹, 曽和 義広, 竹内 一郎, 上田 崇, 木村 泰典, 岩田 健, 中村 晃和, 本郷 文弥, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本癌学会総会記事 71回 327 -327 2012年08月 [無し][無し]
  • 悪性腫瘍の浸潤・転移におけるPAF-PAFRの役割についての検討(The role of PAF and PAFR in malignant cancer cell migration and metastasis)
    田原 秀一, 衣笠 由美, 松井 崇浩, 河内 明宏, 三木 恒治, 高倉 伸幸 日本癌学会総会記事 71回 395 -395 2012年08月 [無し][無し]
  • 泌尿器科領域におけるトラブルシューティング(第32回) 腹腔鏡下腎部分切除術後の仮性腎動脈瘤
    三木 恒治, 本郷 文弥, 河内 明宏 泌尿器外科 25 (7) 1509 -1511 2012年07月 [無し][無し]
  • 前立腺癌のホルモン除去療法における勃起障害の発症率とPDE5阻害薬の有効性に関する検討
    針貝 俊治, 邵 仁哲, 内藤 泰行, 鴨井 和実, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文, 落合 厚 泌尿器科紀要 58 (7) 370 -371 2012年07月 [無し][無し]
  • 骨盤内動静脈奇形の1例
    細田 光洋, 大嶺 卓司, 鴨井 和実, 沖原 宏治, 河内 明宏, 落合 厚 泌尿器科紀要 58 (7) 383 -383 2012年07月 [無し][無し]
  • 腎盂形成術と峡部離断を腹腔鏡下に施行した馬蹄腎の1例
    伊藤 吉三, 中河 秀生, 山田 恭弘, 矢野 公大, 石田 博万, 平原 直樹, 杉本 浩造, 大江 宏, 河内 明宏 泌尿器科紀要 58 (7) 383 -383 2012年07月 [無し][無し]
  • 術後の機能保持を目指した小切開前立腺全摘除術(第2報) 片側筋膜温存術は可能か?
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 河内 明宏, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 4 (1) 47 -50 2012年07月 [無し][無し]
     
    最近の小切開前立腺全摘除術において腫瘍の位置と前立腺周囲筋膜との解剖学的関係から筋膜温存が可能と考えられる症例について筋膜間剥離前立腺全摘除術を行った。両側筋膜間剥離前立腺全摘除術10例と片側筋膜間剥離前立腺全摘除術10例、両側筋膜外剥離前立腺全摘除術20例の年齢、PSA値、生検Gleason score、臨床病期に有意差なく、手術時間、出血量にも有意差はなかった。各手術症例の病理学的病期および外科的切除断端陽性率に違いはなかった。尿漏れPad非使用率は、両側筋膜間剥離手術、片側筋膜間剥離手術、両側筋膜外剥離手術とでそれぞれ3ヵ月後に70%、80%、35%、6ヵ月後に90%、90%、70%であった。このことから、腫瘍の解剖学的位置や進展度から片側、両側の筋膜温存手技を使い分けることが可能であり、片側温存でも良好な尿禁制の回復が期待できると考えられた。(著者抄録)
  • 【患者説明にそのまま使える!よくわかる泌尿器科検査の知識】 (第3章)排尿機能検査士が行う検査 残尿測定
    河内 明宏 泌尿器ケア (2012夏季増刊) 262 -266 2012年06月 [無し][無し]
  • 腹腔鏡下腎部分切除術の経験と最近の手技
    本郷 文弥, 河内 明宏, 三神 一哉, 伊藤 吉三, 内藤 泰行, 邵 仁哲, 納谷 佳男, 鴨井 和実, 三木 恒治 腎癌研究会会報 (42) 37 -37 2012年06月 [無し][無し]
  • T1a腎癌の再発形式 腹腔鏡下腎部分切除術の治療成績に関する多施設共同研究の解析
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 正嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一, 腹腔鏡下腎部分切除術の治療成績に関する研究班 腎癌研究会会報 (42) 94 -95 2012年06月 [無し][無し]
  • 小児昼間尿失禁・夜尿症の取りあつかい 夜尿症と睡眠
    河内 明宏, 内藤 泰行, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 21 (2) 115 -115 2012年06月 [無し][無し]
  • 小児泌尿器科領域の内視鏡手術手技 小児泌尿器科領域の腹腔鏡手術の現況
    河内 明宏 日本小児泌尿器科学会雑誌 21 (2) 118 -118 2012年06月 [無し][無し]
  • 小児泌尿器科領域の内視鏡手術手技 小児泌尿器科領域の腹腔鏡手術 経膀胱アプローチ
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 21 (2) 121 -121 2012年06月 [無し][無し]
  • 小児尿道脱の2例
    内藤 泰行, 河内 明宏, 福井 彩子, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 21 (2) 186 -186 2012年06月 [無し][無し]
  • 当科における難治性夜尿症に対する仙骨表面治療的電気刺激療法
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 23回 39 -39 2012年06月 [無し][無し]
  • 一晩に夜尿を2回以上の症例に対するDDAVPとアラーム併用療法の予後と新たな取り組み
    河内 明宏, 内藤 泰行, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 23回 48 -48 2012年06月 [無し][無し]
  • 【腎疾患治療マニュアル2012-13】 泌尿器科疾患 夜尿症
    河内 明宏, 内藤 泰行, 三木 恒治 腎と透析 72 (増刊) 581 -584 2012年05月 [無し][無し]
  • 毎晩夜尿2回以上ある夜尿症児に対する第一選択としてのアラームとDDAVP併用療法の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 夜尿症研究 17 5 -8 2012年05月 [無し][無し]
     
    目的:明らかに毎晩朝までに2回以上夜尿をしている症例に対する第一選択治療として、アラームとDDAVP併用療法の治療成績を検討した。対象・方法:対象は2009年以降に当科を受診した夜尿症患者のうち、明らかに毎晩2回以上夜尿をしている患児で、第一選択としてDDAVP+アラーム併用療法を施行した30例。コントロールは、明らかに毎晩2回以上夜尿をしている患児でアラームもしくはDDAVP療法を単独で行った37例。結果:アラームとDDAVP併用療法で、治療開始3ヵ月後の有効率は30%であった。コントロール群の有効率は27%であった。併用療法の治療開始6ヵ月後の有効率は50%であった。コントロール群の有効率は32%であった。結論:初診時に明らかに毎晩2回以上の夜尿をする症例に対して、アラームとDDAVP併用療法は推奨される治療法と考える。(著者抄録)
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintetsu Soh, Kazumi Kamoi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 187 (4) E246 -E246 2012年04月 [無し][無し]
  • Jintetsu Soh, Noriyuki Kanemitsu, Atsushi Ochiai, Yasuyuki Naitoh, Yoshio Naya, Kazumi Kamoi, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 187 (4) E463 -E464 2012年04月 [無し][無し]
  • Hisashi Honjo, Masahiro Nakao, Jun Ueyama, Takaaki Kondo, Osamu Ukimura, Akihiro Kawauchi, Hiroshi Kitakoji, Nobuyuki Hamajima, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 187 (4) E701 -E702 2012年04月 [無し][無し]
  • Natsuki Takaha, Ichiro Takeuchi, Yasunori Kimura, Tsuyoshi Iwata, Terukazu Nakamura, Fumiya Hongo, Kazuya Mikami, Kazumi Kamoi, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki CANCER RESEARCH 研究発表ペーパー・要旨(国際会議) 72 2012年04月 [無し][無し]
  • Hideo Saito, Tadashi Matsuda, Kazunari Tanabe, Akihiro Kawauchi, Toshiro Terachi, Ken Nakagawa, Masatsugu Iwamura, Masanobu Shigeta, Seiji Naito, Akihiro Ito, Yoichi Arai JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 187 (4) E289 -E289 2012年04月 [無し][無し]
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintetsu Soh, Kazumi Kamoi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 187 (4) E224 -E224 2012年04月 [無し][無し]
  • 前立腺・その他 術後の機能保持を目指した小切開前立腺全摘除術(第2報) 片側筋膜温存術は可能か?
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 河内 明宏, 三木 恒治 泌尿器外科 25 (4) 801 -801 2012年04月 [無し][無し]
  • 【骨盤内解剖】 前立腺全摘除術における機能温存手技
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 25 (1) 37 -42 2012年04月 [無し][無し]
     
    最近の小切開前立腺全摘除術において腫瘍の位置と前立腺周囲筋膜との解剖学的関係から筋膜温存が可能と考えられる症例について筋膜間剥離前立腺全摘除術を行った。両側筋膜間剥離前立腺全摘除術11例と片側筋膜間剥離前立腺全摘除術10例、両側筋膜外剥離前立腺全摘除術24例の年齢、PSA値、生検Gleason score、臨床病期に有意差なく、手術時間、出血量にも有意差はなかった。各手術症例の病理学的病期および外科的切除断端陽性率に違いはなかった。尿漏れPad非使用率は、両側筋膜間剥離手術、片側筋膜間剥離手術、両側筋膜外剥離手術とでそれぞれ3ヵ月後に73%、80%、28%、6ヵ月後に90%、91%、63%であった。観察期間1-24ヵ月(中央値12ヵ月)での生化学的再発率はそれぞれ0%、0%、8%であった。このことから、腫瘍の解剖学的位置や進展度から片側、両側の筋膜温存手技を使い分けることが可能であり、片側温存でも良好な尿禁制の回復が期待できると考えられた。(著者抄録)
  • 小径腎癌の治療戦略 長期予後を含めて 腹腔鏡下腎部分切除の腫瘍学的アウトカム
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 正嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一, 腹腔鏡下腎部切除術の治療成績に関する研究班 日本泌尿器科学会雑誌 103 (2) 94 -94 2012年03月 [無し][無し]
  • 単孔式泌尿器腹腔鏡手術の現状と展開 単孔式腹腔鏡下腎盂形成術
    河内 明宏, 内藤 泰行, 邵 仁哲, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 157 -157 2012年03月 [無し][無し]
  • 先進医療としての腹腔鏡下手術 腹腔鏡下逆流防止術および腹腔鏡下膀胱内手術
    河内 明宏, 内藤 泰行, 邵 仁秀, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 163 -163 2012年03月 [無し][無し]
  • 当科における単孔式腹腔鏡下腎盂形成術(Laparoendoscopic Single Site Surgery(LESS)for pyeloplasty)の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 鴨井 和実, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 189 -189 2012年03月 [無し][無し]
  • 京都府立医大単一施設での進行性精巣腫瘍に対する化学療法後の残存腫瘍に対するRPLNDの検討
    中村 晃和, 木村 泰典, 三神 一哉, 本郷 文弥, 山田 剛司, 上田 崇, 高羽 夏樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 206 -206 2012年03月 [無し][無し]
  • 尿中NGF増加は前立腺肥大に伴う下部尿路症状発症および血清NOx値低下に関連する 住民検診受診男性における検討
    本城 久司, 中尾 昌宏, 上山 純, 近藤 高明, 鴨井 和実, 浮村 理, 河内 明宏, 北小路 博司, 浜島 信之, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 224 -224 2012年03月 [無し][無し]
  • 前立腺癌のホルモン除去療法における勃起障害の発症率とPDE5阻害薬の有効性に関する検討
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 鴨井 和実, 藤原 光文, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 229 -229 2012年03月 [無し][無し]
  • 当科における体腔鏡下腎部分切除術および最近の手技
    金沢 元洪, 本郷 文弥, 朴 英寿, 納谷 佳男, 伊藤 吉三, 内藤 泰行, 邵 仁哲, 鴨井 和実, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 246 -246 2012年03月 [無し][無し]
  • 尿管・膀胱子宮内膜症に対する腹腔鏡下手術の経験
    藤原 敦子, 河内 明宏, 本郷 文弥, 楠木 泉, 北脇 城, 國場 幸均, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 249 -249 2012年03月 [無し][無し]
  • 直径1cm以下のTarget Lesionに対するMRI-US Fusion Biopsyの有用性の検討
    鴨井 和実, 沖原 宏治, 岩田 健, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 251 -251 2012年03月 [無し][無し]
  • 前立腺癌細胞のアンドロゲン非依存性増殖およびドセタキセル抵抗性獲得におけるhigh mobility group protein AT-hook 1(HMGA1)の役割
    高羽 夏樹, 曽和 義広, 竹内 一郎, 上田 崇, 木村 泰典, 岩田 健, 中村 晃和, 本郷 文弥, 三神 一哉, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 372 -372 2012年03月 [無し][無し]
  • アンドロゲン受容体転写抑制因子を介した精巣腫瘍発生の分子機構の解析
    上田 崇, 上田 紗弥, 木村 泰典, 中村 晃和, 本郷 文弥, 三神 一哉, 高羽 夏樹, 河内 明宏, 武山 健一, 三木 恒治, 加藤 茂明 日本泌尿器科学会雑誌 103 (2) 433 -433 2012年03月 [無し][無し]
  • Peyronie病に対するニカルジピンvs.生理食塩水局所注入療法の検討 A prospective、Randomised、Single-Blind Trial
    兼光 紀幸, 邵 仁哲, 納谷 佳男, 落合 厚, 内藤 泰行, 鴨井 和実, 河内 明宏, 藤原 光文, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 437 -437 2012年03月 [無し][無し]
  • 去勢抵抗性前立腺癌に対するドセタキセル化学療法の治療効果予測因子の同定
    山田 剛司, 高羽 夏樹, 沖原 宏治, 岩田 健, 本郷 文弥, 鴨井 和実, 河内 明宏, 南口 尚紀, 伊藤 吉三, 米田 公彦, 大嶺 卓司, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 480 -480 2012年03月 [無し][無し]
  • 酪酸菌による好中球からのTRAIL放出機構の解析とその臨床応用への検討
    神農 雅秀, 堀中 真野, 上田 崇, 木村 泰典, 中村 晃和, 本郷 文弥, 三神 一哉, 高羽 夏樹, 河内 明宏, 酒井 敏行, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 488 -488 2012年03月 [無し][無し]
  • 体腔鏡下腎尿管全摘にともなって行ったリンパ節郭清術の臨床的経験
    藤井 秀岳, 廣田 英二, 中内 博夫, 兼光 紀幸, 増田 健人, 本郷 文弥, 邵 仁哲, 三神 一哉, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 517 -517 2012年03月 [無し][無し]
  • 進行性精巣腫瘍の化学療法後残存腫瘍に対するdesperation surgeryの経験
    木村 泰典, 中村 晃和, 三神 一哉, 山田 剛司, 本郷 文弥, 河内 明宏, 高羽 夏樹, 三木 恒治 日本泌尿器科学会雑誌 103 (2) 527 -527 2012年03月 [無し][無し]
  • 骨盤内動静脈奇形の一例
    細田 光洋, 大嶺 卓司, 鴨井 和実, 沖原 宏治, 河内 明宏, 落合 厚 超音波医学 39 (2) 213 -213 2012年03月 [無し][無し]
  • 小径腎腫瘍における良性腫瘍の頻度 腹腔鏡下腎部分切除術の治療成績に関する多施設共同研究1,375例の解析
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 政嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一 日本腎泌尿器疾患予防医学研究会誌 20 (1) 70 -71 2012年03月 [無し][無し]
  • 前立腺がん検診ガイドライン 「1次検診受診後のファクトシート」についてのアンケート調査 2年目の報告
    北村 浩二, 藤原 淳, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 20 (1) 97 -99 2012年03月 [無し][無し]
  • 基幹病院の新規前立腺癌患者数の統計解析からみた、今後の前立腺がん罹患数予測の再考
    鴨井 和実, 岩田 健, 沖原 宏治, 三神 一哉, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 20 (1) 100 -101 2012年03月 [無し][無し]
  • Kazumi Kamoi, Koji Okihara, Natsuki Takaha, Tsuyoshi Iwata, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 30 (5) 2012年02月 [無し][無し]
  • Y. Naitoh, A. Kawauchi, J. Soh, K. Kamoi, T. Miki EUROPEAN UROLOGY SUPPLEMENTS 研究発表ペーパー・要旨(国際会議) 11 (1) E504 -U95 2012年02月 [無し][無し]
  • A. Fujihara, O. Ukimura, H. Honjo, T. Iwata, T. Ueda, K. Kamoi, A. Kawauchi, T. Miki EUROPEAN UROLOGY SUPPLEMENTS 研究発表ペーパー・要旨(国際会議) 11 (1) E629 -U349 2012年02月 [無し][無し]
  • Y. Naitoh, A. Kawauchi, J. Soh, K. Kamoi, T. Miki EUROPEAN UROLOGY SUPPLEMENTS 研究発表ペーパー・要旨(国際会議) 11 (1) E400 -U881 2012年02月 [無し][無し]
  • Kazumi Kamoi, Koji Okihara, Natsuki Takaha, Tsuyoshi Iwata, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 30 (5) 2012年02月 [無し][無し]
  • 胃癌術後5年目で精索転移を認めた1例
    中河 秀生, 中村 晃和, 木村 泰典, 藤原 敦子, 岩田 健, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 泌尿器科紀要 58 (2) 122 -122 2012年02月 [無し][無し]
  • 診断に苦慮した尿管Endometriosisの1例
    宮下 雅亜, 内藤 泰行, 藤井 秀岳, 木村 泰典, 藤原 敦子, 岩田 健, 鴨井 和実, 三神 一哉, 沖原 宏治, 高羽 夏樹, 河内 明宏, 三木 恒治 泌尿器科紀要 58 (2) 130 -130 2012年02月 [無し][無し]
  • 前立腺・その他 術後の機能保持を目指した小切開前立腺全摘除術(第2報) 片側筋膜温存術は可能か?
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 河内 明宏, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 3 (2) 28 -28 2011年12月 [無し][無し]
  • 平原 直樹, 山田 恭弘, 矢野 公大, 石田 博万, 中河 秀生, 大江 宏, 伊藤 吉三, 河内 明宏, 岡田 安弘, 坂井 龍太 京都第二赤十字病院医学雑誌 32 96 -100 2011年12月 [無し][無し]
     
    右腎細胞癌による右腎摘出25年後に、左腎に発症した腎細胞癌を経験した。症例は67歳男性。42歳時に右腎細胞癌(clear cell carcinoma)のため根治的右腎摘除術をうけた。25年後の今回、左腎に発症した4.0cm径の腫瘍に対して左腎部分切除術を施行し腫瘍を摘出した。病理組織学診断はclear cell carcinomaであった。後発腫瘍は左腎に単発であり、他に転移巣は無く、右腎癌摘出時より長期間経過した後の発症であるところから、腫瘍は晩期発症の転移性癌とするよりも、非同時性の両側原発性腎細胞癌とするのが妥当であると思われた。(著者抄録)
  • 検診の精度管理 前立腺がん検診従事者の教育
    北村 浩二, 藤原 淳, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 19 (2) 159 -161 2011年12月 [無し][無し]
     
    京都府乙訓地区では1995年より継続して前立腺がん検診を行っており、この経験を基に精度管理に係る検診従事者の教育について振り返って検討した。検診を継続して行うと見つかる前立腺がんのほとんどが触診や超音波検査で検出が困難なT1cがんであり、読影能力の差が精度管理に与える影響はほとんどないものと思われた。最も技術の差が出ると予想される手技は前立腺針生検であるが、乙訓前立腺がん検診では、ある程度経験をつんだ泌尿器科医であれば誰でも同等に生検をすることができ、特別な指導教育は不要であった。検診の継続、そして検診結果を地区医師会に常にフィードバックすることが、一次検診従事者に対する最大の教育になっており、検診受診率や精検受診率の向上につながっているものと思われた。前立腺がん検診は他の検診に比べて特殊な技術や卓越した読影能力を必要とすることも少なく、精度管理をしやすい検診である。検診を継続して行っていくことが、検診従事者に対する最も効果的な教育になっていると考えられた。(著者抄録)
  • 前立腺癌のホルモン除去療法における勃起障害の発症率とPDE5阻害薬の有効性に関する検討
    邵 仁哲, 内藤 泰行, 鴨井 和美, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文, 落合 厚 日本性機能学会雑誌 26 (3) 270 -270 2011年12月 [無し][無し]
  • 副腎・腎摘出術における単孔式手術 京都府立医大における副腎・腎摘除術における単孔式手術の経験
    河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 本郷 文弥, 沖原 宏治, 三木 恒治 日本内視鏡外科学会雑誌 16 (7) 195 -195 2011年12月 [無し][無し]
  • 泌尿器科領域における手術法、合併症軽減の工夫 腹腔鏡下腎部分切除術の手術手技の工夫
    本郷 文弥, 河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 三木 恒治 日本内視鏡外科学会雑誌 16 (7) 267 -267 2011年12月 [無し][無し]
  • 泌尿器科領域における手術法、合併症軽減の工夫 経膀胱的腹腔鏡下逆流防止術の工夫
    内藤 泰行, 河内 明宏, 邵 仁哲, 本郷 文弥, 鴨井 和実, 三木 恒治 日本内視鏡外科学会雑誌 16 (7) 267 -267 2011年12月 [無し][無し]
  • Fumiya Hongo, Akihiro Kawauchi, Yasunori Kimura, Yasuyuki Naitoh, Jintetsu Soh, Kazumi Kamoi, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 25 A102 -A102 2011年11月 [無し][無し]
  • Hideo Saito, Matsuda Tadashi, Kazunari Tanabe, Toshiro Terachi, Masatsugu Iwamura, Ken Nakagawa, Masanobu Shigeta, Akihiro Kawauchi, Seiji Naito, Akihiro Ito JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 25 A158 -A159 2011年11月 [無し][無し]
  • Kazumi Kamoi, Koji Okihara, Fumiya Hongo, Yasuyuki Naitoh, Tsuyoshi Iwata, Yasunori Kimura, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 25 A229 -A229 2011年11月 [無し][無し]
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintetsu Soh, Fumiya Hongo, Kazumi Kamoi, Tsuneharu Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 25 A59 -A59 2011年11月 [無し][無し]
  • 右腎外傷を契機に発見されたWilms腫瘍の1例
    鳴川 司, 内藤 泰行, 藤原 敦子, 邵 仁哲, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治, 北森 伴人, 中河 祐治, 小林 徳朗 泌尿器科紀要 57 (11) 662 -662 2011年11月 [無し][無し]
  • 奥山 智緒, 松島 成典, 内藤 泰行, 河内 明宏, 三木 恒治 核医学 48 (4) 465 -465 2011年11月 [無し][無し]
  • 2型糖尿病男性患者における加齢によるテストステロン値の変動の検討
    邵 仁哲, 兼光 紀幸, 内藤 泰行, 納谷 佳男, 落合 厚, 鴨井 和美, 河内 明宏, 福井 道明, 三木 恒治 日本老年泌尿器科学会誌 24 62 -62 2011年11月 [無し][無し]
  • 高齢者(75歳以上)去勢抵抗性前立腺癌に対するドセタキセルを基調とした化学療法の臨床成績に関する検討
    高羽 夏樹, 沖原 宏治, 岩田 健, 本郷 文弥, 鴨井 和実, 河内 明宏, 南口 尚紀, 矢野 公大, 伊藤 吉三, 米田 公彦, 大嶺 卓司, 三木 恒治 日本老年泌尿器科学会誌 24 93 -93 2011年11月 [無し][無し]
  • Atsushi Ochiai, Koji Okihara, Kazumi Kamoi, Tsuyoshi Iwata, Akihiro Kawauchi, Tsuneharu Miki INTERNATIONAL JOURNAL OF UROLOGY 速報,短報,研究ノート等(学術雑誌) 18 (10) 737 -737 2011年10月 [無し][無し]
  • 【腹腔鏡下腎部分切除】腹腔鏡下腎部分切除術の周術期合併症と長期腫瘍学的アウトカム 日本泌尿器内視鏡学会多施設共同研究
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 正嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一 Japanese Journal of Endourology 24 (3) 64 -64 2011年10月 [無し][無し]
  • 単孔式腹腔鏡手術(Laparoendoscopic Single Site Surgery:LESS)による腎盂形成術16例の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 本郷 文弥, 鴨井 和実, 三木 恒治 Japanese Journal of Endourology 24 (3) 88 -88 2011年10月 [無し][無し]
  • 腹腔鏡下腎部分切除術の手術成績およびoncological outcome 日本における多施設共同研究1,375例の解析より
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 正嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一 Japanese Journal of Endourology 24 (3) 90 -90 2011年10月 [無し][無し]
  • 腹腔鏡下に腎盂形成術と峡部離断を施行した馬蹄腎の1例
    伊藤 吉三, 中河 秀生, 山田 恭弘, 矢野 公大, 石田 博万, 平原 直樹, 大江 宏, 河内 明宏 Japanese Journal of Endourology 24 (3) 106 -106 2011年10月 [無し][無し]
  • 体腔鏡下腎部分切除術の経験と最新の手技
    木村 泰典, 本郷 文弥, 内藤 泰行, 邵 仁哲, 鴨井 和実, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 24 (3) 119 -119 2011年10月 [無し][無し]
  • 術後の機能温存を目指した解剖学的知識に基づく小切開前立腺全摘除術
    鴨井 和実, 沖原 宏治, 本郷 文弥, 内藤 泰行, 岩田 健, 木村 泰典, 河内 明宏, 三木 恒治 Japanese Journal of Endourology 24 (3) 133 -133 2011年10月 [無し][無し]
  • 超高速MRIを用いた勃起・射精の動的観察
    邵 仁哲, 鴨井 和美, 東 高志, 中井 隆介, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 26 (2) 131 -132 2011年09月 [無し][無し]
  • 泌尿器 腹腔鏡下腎部分切除術における良性腫瘍の頻度 多施設共同研究1,375例の解析
    齋藤 英郎, 松田 公志, 田邊 一成, 寺地 敏郎, 岩村 正嗣, 中川 健, 繁田 正信, 河内 明宏, 内藤 誠二, 伊藤 明宏, 荒井 陽一 日本癌治療学会誌 46 (2) 459 -459 2011年09月 [無し][無し]
  • 去勢抵抗性前立腺癌患者の治療アルゴリズムの提唱
    鴨井 和実, 沖原 宏治, 高羽 夏樹, 岩田 健, 河内 明宏, 三木 恒治 日本癌治療学会誌 46 (2) 575 -575 2011年09月 [無し][無し]
  • 去勢抵抗性前立腺癌に対するドセタキセル化学療法の治療効果予測因子の検討
    高羽 夏樹, 沖原 宏治, 岩田 健, 本郷 文弥, 鴨井 和実, 河内 明宏, 南口 尚紀, 伊藤 吉三, 米田 公彦, 大嶺 卓司, 三木 恒治 日本癌治療学会誌 46 (2) 578 -578 2011年09月 [無し][無し]
  • 前立腺癌中間リスク群に対する、内分泌併用密封小線源療法の治療成績
    沖原 宏治, 岩田 健, 内藤 泰行, 鴨井 和実, 小林 加奈, 山崎 秀哉, 河内 明宏, 三木 恒治 日本癌治療学会誌 46 (2) 676 -676 2011年09月 [無し][無し]
  • 局所進行性膀胱癌に対する周術期化学療法の意義
    三神 一哉, 木村 泰典, 白石 匠, 中村 晃和, 本郷 文弥, 高羽 夏樹, 河内 明宏, 三木 恒治 日本癌治療学会誌 46 (2) 679 -679 2011年09月 [無し][無し]
  • 進行性腎細胞癌に対するエベロリムスの治療経験
    大石 正勝, 本郷 文弥, 宮下 雅亜, 木村 泰典, 中村 晃和, 三神 一哉, 高羽 夏樹, 河内 明宏, 三木 恒治 日本癌治療学会誌 46 (2) 934 -934 2011年09月 [無し][無し]
  • 腎盂尿管腫瘍に対する腹腔鏡下後腹膜リンパ節郭清術の検討
    河内 明宏, 中村 晃和, 本郷 文弥, 木村 泰典, 三神 一哉, 鳥山 清二郎, 落合 厚, 牛嶋 壮, 増田 健人, 中内 博夫, 三木 恒治 日本癌治療学会誌 46 (2) 941 -941 2011年09月 [無し][無し]
  • 当院における小切開根治的前立腺全摘除術
    岩田 健, 沖原 宏治, 牛嶋 壮, 山田 剛司, 藤原 敦子, 鴨井 和実, 河内 明宏, 三木 恒治 日本癌治療学会誌 46 (2) 960 -960 2011年09月 [無し][無し]
  • 【Focal therapy】 泌尿器科腫瘍(原発巣・転移巣)に対するラジオ波焼灼術
    中村 晃和, 河内 明宏, 山上 卓士, 平岡 健二, 藤原 淳, 木村 泰典, 三神 一哉, 本郷 文弥, 三木 恒治 Japanese Journal of Endourology 24 (2) 180 -187 2011年09月 [無し][無し]
     
    【緒言】当科における小径腎腫瘍(small renal mass:SRM)および精巣腫瘍の肺・肝転移腫瘍(精巣腫瘍、TC)に対する有効性及び安全性を検討したので報告する。【対象と方法】小径腎腫瘍(SRM)43症例(43腫瘍)および進行性精巣腫瘍19例(42腫瘍、肺32腫瘍、肝10腫瘍)を対象とした。【結果】SRM:38症例(86.4%)で完全焼灼が得られた。30mm以下の腫瘍では完全焼灼率は93.8%であり、30mmを超える腫瘍(63.6%)と比較して治療成績に有意に良好であった。また、RFAの前後で腎機能の増悪は認められず、観察期間の中央値は16ヵ月(1-63ヵ月)で、1例(2.9%)に再発を認めた。TC:全体では82.3%で有効な焼灼が施行され、根治目的群では有効率は100%であった。また、30mm以下の腫瘍においても100%の局所コントロール率を得ることができた。【結論】経皮的RFAは小径腎腫瘍や精巣腫瘍肺・肝転移巣に対して有効な治療手段であることが示された。(著者抄録)
  • 腎細胞癌におけるhigh mobility group protein AT-hook 1(HMGA1)の役割(Role of high mobility group protein AT-hook 1(HMGA1) in human renal cell carcinoma)
    高羽 夏樹, 曽和 義広, 竹内 一郎, 木村 泰典, 中村 晃和, 本郷 文弥, 三神 一哉, 河内 明宏, 三木 恒治 日本癌学会総会記事 70回 148 -148 2011年09月 [無し][無し]
  • 血清XIAPの腎癌の腫瘍マーカーとしての有用性(Serum XIAP as a prognostic marker of RCC)
    本郷 文弥, 高羽 夏樹, 木村 泰典, 中村 晃和, 三神 一哉, 河内 明宏, 三木 恒治 日本癌学会総会記事 70回 363 -364 2011年09月 [無し][無し]
  • 酪酸菌による好中球からのTRAIL誘導とその抗腫瘍効果の検討(The stimulation of Clostridium butyricum on neutrophils causes the release of TRAIL)
    神農 雅秀, 堀中 真野, 本郷 文弥, 高羽 夏樹, 河内 明宏, 三木 恒治, 酒井 敏行 日本癌学会総会記事 70回 373 -373 2011年09月 [無し][無し]
  • VAS問診票を用いたDutasterideとα遮断剤併用療法の効果の検討
    林 一誠, 鴨井 和実, 沖原 宏治, 藤原 敦子, 岩田 健, 河内 明宏, 三木 恒治 日本排尿機能学会誌 22 (1) 226 -226 2011年09月 [無し][無し]
  • 限局性膀胱アミロイドーシスの1例
    松ヶ角 透, 鴨井 和実, 針貝 俊治, 稲垣 哲典, 木村 泰典, 平原 直樹, 邵 仁哲, 中川 修一, 河内 明宏, 三木 恒治 泌尿器科紀要 57 (8) 439 -443 2011年08月 [無し][無し]
     
    76歳男。約1年10ヵ月前に肉眼的血尿を認めるが悪性所見はなく経過観察とされた。その後、肉眼的血尿を認めたため膀胱鏡を施行したところ、膀胱内に凝血塊、粘膜下出血を認めたが、止血剤にて消失した。以後、約3ヵ月ごとに増悪軽快を繰り返すため紹介受診となった。膀胱鏡では、膀胱内に多数の粘膜下出血、両側尿管口・三角部を中心に隆起性病変を認めた。MRIでは全周性に膀胱壁の肥厚、多数のポリープ状隆起性病変を認めた。経尿道的膀胱生検と止血凝固術を施行した。生検された組織はHE染色において好酸性で均質無構造・硝子状を示す線維状構造を認め、Congored染色を行ったところ、線維状構造物は赤橙色に染色され、偏光顕微鏡で緑色の複偏光性を示した。免疫染色にてアミロイドP蛋白が陽性、アミロイドAが陰性であることから、AL型アミロイドーシスと診断した。また、全身検索で関節腫脹・変形、骨びらん、皮下結節は認めず、上下部消化管内視鏡でアミロイド沈着は認めず、限局性膀胱アミロイドーシスと診断した。DMSOによる経皮的密封吸収療法(ODT)を開始し、12ヵ月後に肉眼的血尿の出現頻度は著明に減少し、膀胱鏡、MRIで改善を認め、現在もDMSO-ODT療法を継続している。
  • 【前立腺肥大症診療ガイドライン-その概要と位置づけ】 診断と評価
    河内 明宏, 三木 恒治 泌尿器外科 24 (7) 1101 -1109 2011年07月 [無し][無し]
     
    前立腺肥大症を想定した場合に必ず行うべき評価(基本評価)としては、病歴聴取、症状・QOL評価(CLSS、IPSS、OABSS)、身体所見、尿検査、尿流測定、残尿測定、前立腺超音波検査、血清PSA測定があげられた。症例を選択して行う評価(選択評価)としては、排尿記録、尿流動体検査、血清クレアチニン値測定、上部尿路超音波検査などがあげられた。(著者抄録)
  • 術後の機能温存を目指した解剖学的知識に基づく小切開前立腺全摘除術
    鴨井 和実, 沖原 宏治, 岩田 健, 木村 泰典, 河内 明宏, 三木 恒治 日本ミニマム創泌尿器内視鏡外科学会雑誌 3 (1) 63 -67 2011年07月 [無し][無し]
     
    目的;前立腺癌に対する外科的治療は、近年の前立腺とその周囲組織の解剖学的理解と外科的手技の進歩によって改善してきた。前立腺周囲の多重筋膜の同定は、腫瘍学的に適正な前立腺摘出のための切除プランの決定と尿禁制を司る外尿道括約筋および勃起機能を司る自律神経の温存を可能にする。本稿は、前立腺とその周囲組織の解剖学的理解に基づく、良好な機能温存とより安全な腫瘍学的切除を目標とした小切開前立腺全摘除術を提示する事を目的とした。方法;骨盤底筋膜(endopelvic fascia)は前立腺側・後面を覆う臓側骨盤底筋膜(visceral endopelvic fascia)と前立腺前面を覆う頂部骨盤底筋膜(parietal endopelvic fascia)が骨盤筋膜腱弓(fascialtendinous arch of the pelvis)において癒合しており、骨盤筋膜腱弓は恥骨前立腺靱帯からの白線として認識される。この骨盤筋膜腱弓より外側の筋膜をすべて温存する筋膜間剥離前立腺全摘除術(inter-fascial radical prostatectomy)を行うことによって、尿禁制の早期回復が可能になるとされている。われわれは、最近の小切開前立腺全摘除術において腫瘍の位置と前立腺周囲筋膜との解剖学的関係から筋膜温存が可能と考えられる症例について筋膜間剥離前立腺全摘除術を行った。本術式による周術期および術後尿失禁の結果を直近の筋膜外剥離前立腺全摘除術(extra-fascial radical prostatectomy)と比較した。結果;筋膜間剥離前立腺全摘除術10例と筋膜外剥離前立腺全摘除術10例の年齢、PSA値、生検Gleason score、臨床病期に有意差なく、手術時間、出血量にも有意差はなかった。筋膜間剥離前立腺全摘除術では4例に片側神経血管束温存が6例に両側神経血管束温存が行われた。筋膜外剥離前立腺全摘除術では2例で神経血管束非温存、6例で片側神経血管束温存、2例で両側神経血管束温存が施行された。両手術症例の病理学的病期および外科的切除断端陽性率に違いはなかった。尿漏れPad使用率は、筋膜外剥離と筋膜間剥離手術でそれぞれ3ヵ月後に70%対20%、6ヵ月後に30%対0%であった。結論;前立腺周囲の詳細な解剖学的構造の解明によって前立腺全摘除術中の最適な切除面の選択が可能となり、術後尿禁制の改善が期待される。(著者抄録)
  • 【見ること・することリストで一目瞭然!術式別泌尿器科の術前・術後ケア】 泌尿器科手術の術前・術後ケア 腎臓の手術 腎尿管全摘除術
    河内 明宏, 釜子 優美子 泌尿器ケア (2011夏季増刊) 74 -85 2011年06月 [無し][無し]
  • 夜間2回以上の夜尿症児に対する第一選択としてのDDAVPとアラーム併用療法の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 22回 19 -19 2011年06月 [無し][無し]
  • 過活動膀胱症状質問票を用いた夜尿症患者の評価
    河内 明宏, 内藤 泰行, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 22回 28 -28 2011年06月 [無し][無し]
  • 気膀胱下腹腔鏡手術の応用
    河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 三木 恒治 日本小児泌尿器科学会雑誌 20 (2) 166 -166 2011年06月 [無し][無し]
  • 単孔式腹腔鏡手術(Laparoendoscopic Single Site Surgery:LESS)による腎盂形成術16例の経験
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 20 (2) 189 -189 2011年06月 [無し][無し]
  • N. Takaha, T. Iwata, T. Nakamura, F. Hongo, K. Kamoi, K. Okihara, A. Kawauchi, T. Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 29 (15) 2011年05月 [無し][無し]
  • K. Kamoi, K. Okihara, N. Takaha, T. Nakamura, F. Hongo, Y. Naito, A. Kawauchi, T. Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 29 (15) 2011年05月 [無し][無し]
  • Y. Naito, A. Kawauchi, K. Kamoi, K. Okihara, T. Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 29 (15) 2011年05月 [無し][無し]
  • 当科における5α-reductase inhibitor(Dutasteride)とα遮断剤併用療法の経験
    粥川 成優, 鴨井 和実, 沖原 宏治, 稲垣 哲典, 藤原 敦子, 岩田 健, 河内 明宏, 三木 恒治 泌尿器科紀要 57 (5) 266 -266 2011年05月 [無し][無し]
  • 進行性腎細胞癌に対するエベロリムスの初期治療経験
    大石 正勝, 本郷 文弥, 木村 泰典, 中村 晃和, 三神 一哉, 高羽 夏樹, 河内 明宏, 三木 恒治, 中川 修一 泌尿器科紀要 57 (5) 272 -272 2011年05月 [無し][無し]
  • Jintetsu Soh, Yoshio Naya, Atsushi Ochiai, Yasuyuki Naitoh, Noriyuki Kanemitsu, Kazumi Kamoi, Kawauchi Akihiro, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 185 (4) E727 -E727 2011年04月 [無し][無し]
  • Natsuki Takaha, Ichiro Takeuchi, Yoshihiro Sowa, Yasunori Kimura, Terukazu Nakamura, Fumiya Hongo, Kazuya Mikami, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 185 (4) E97 -E97 2011年04月 [無し][無し]
  • Hisashi Honjo, Masahiro Nakao, Jun Ueyama, Takaaki Kondo, Osamu Ukimura, Akihiro Kawauchi, Hiroshi Kitakoji, Nobuyuki Hamajima, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 185 (4) E781 -E781 2011年04月 [無し][無し]
  • Natsuki Takaha, Ichiro Takeuchi, Yoshihiro Sowa, Yasunori Kimura, Terukazu Nakamura, Fumiya Hongo, Kazuya Mikami, Akihiro Kawauchi, Tsuneharu Miki CANCER RESEARCH 研究発表ペーパー・要旨(国際会議) 71 2011年04月 [無し][無し]
  • Hideo Saito, Tadashi Matsuda, Kazunari Tanabe, Akihiro Kawauchi, Toshiro Terachi, Ken Nakagawa, Masatsugu Iwamura, Masanobu Shigeta, Akihiro Ito, Yoichi Arai JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 185 (4) E743 -E743 2011年04月 [無し][無し]
  • Jintetsu Soh, Yoshio Naya, Atsushi Ochiai, Yasuyuki Naitoh, Noriyuki Kanemitsu, Kazumi Kamoi, Kawauchi Akihiro, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 185 (4) E925 -E926 2011年04月 [無し][無し]
  • Yasuyuki Naito, Akihiro Kawauchi, Kazumi Kamoi, Jintetsu Soh, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 185 (4) E226 -E226 2011年04月 [無し][無し]
  • 巨大前立腺肥大症の1例
    高村 俊哉, 藤原 敦子, 稲垣 哲典, 鳴川 司, 宮下 雅亜, 岩田 健, 邵 仁哲, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治, 北森 伴人 泌尿器科紀要 57 (4) 219 -219 2011年04月 [無し][無し]
  • 【腎癌の手術・腎機能に焦点をあてて】 腎癌のラジオ波焼灼術 腎機能を中心に
    中村 晃和, 河内 明宏, 平岡 健児, 三木 恒治 泌尿器外科 24 (4) 575 -579 2011年04月 [無し][無し]
     
    小径腎腫瘍、特にT1a腎がんに対しては、腎機能温存および長期予後の改善といった観点から腎部分切除が第一選択の治療法となってきている。しかし、全身麻酔下の手術を行えないような合併症を有する場合、経皮的治療が可能なRadiofrequency ablation(RFA)は非常に魅力的な選択肢となりうる。現在、各種のガイドラインでは、制限付きながら、ある程度のコンセンサスが得られたといえる。RFAは、有意な腎機能低下を生じないことから、腎機能温存の面からも、有効な選択肢の一つとなりうると考えられる。(著者抄録)
  • 前立腺・膀胱・その他 術後の機能保持を目指した解剖学的知識に基づく小切開前立腺全摘除術
    鴨井 和実, 沖原 宏治, 岩田 健, 河内 明宏, 三木 恒治 泌尿器外科 24 (4) 665 -665 2011年04月 [無し][無し]
  • 加齢男性性腺機能低下症候群(LOH症候群)に対するアンドロゲン補充療法の治療前後における各種ホルモン値の変動に関する検討
    邵 仁哲, 兼光 紀幸, 内藤 泰行, 河内 明宏, 三木 恒治, 鴨井 和実, 納谷 佳男, 落合 厚 日本抗加齢医学会総会プログラム・抄録集 11回 236 -236 2011年04月 [無し][無し]
  • J. Soh, K. Kamoi, N. Kanemitsu, A. Ochiai, Y. Naya, Y. Naitoh, A. Kawauchi, T. Fujiwara, T. Miki EUROPEAN UROLOGY SUPPLEMENTS 研究発表ペーパー・要旨(国際会議) 10 (2) 317 -317 2011年03月 [無し][無し]
  • 【泌尿器科における単孔式腹腔鏡下手術】 腎盂尿管移行部狭窄症に対する単孔式腹腔鏡下腎盂形成術
    河内 明宏, 内藤 泰行, 稲垣 哲典, 邵 仁哲, 鴨井 和実, 三木 恒治 臨床泌尿器科 65 (3) 201 -206 2011年03月 [無し][無し]
     
    腎盂尿管移行部狭窄症10例に対し,単孔式腹腔鏡下腎盂形成術を施行した。Triportを臍部より挿入し,2〜3mmのポートを追加して行った。5mmフレキシブルスコープ,術者の右手用の器具,助手の屈曲型鉗子をTriportの3つの鉗子孔より挿入し,追加ポートは術者の左手用とした。手術時間は通常の腹腔鏡下腎盂形成術の1.5倍程度かかるが,出血は少量で,合併症はなく,整容性は非常に優れていた。手術成績も評価可能であった全症例で,水腎の改善を認め,症状のあったものは症状の改善も認めた。本法は腎盂形成術の第1選択の術式になる可能性があると考えられた。(著者抄録)
  • 泌尿器腹腔鏡手術の進歩と課題 泌尿器科における単孔式腹腔鏡手術(Laparoendoscopic Single Site Surgery LESS)の現状と将来展望
    河内 明宏, 内藤 泰行, 鴨井 和実, 邵 仁哲, 沖原 宏治, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 120 -120 2011年03月 [無し][無し]
  • 腎癌治療の課題と新なる展開 腎癌に対する局所療法
    本郷 文弥, 河内 明宏, 中村 晃和, 平岡 健児, 木村 泰典, 鴨井 和実, 三神 一哉, 山上 卓士, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 128 -128 2011年03月 [無し][無し]
  • 小児泌尿器科領域における内視鏡手術 当科における腹腔鏡下膀胱尿管逆流防止術その特徴と治療成績
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 134 -134 2011年03月 [無し][無し]
  • 前立腺肥大症診療ガイドライン 作成の経緯と今後の展望 診断について
    河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 137 -137 2011年03月 [無し][無し]
  • 専門医のための画像診断 進行性精巣癌における化学療法後の画像診断
    三神 一哉, 木村 泰典, 中村 晃和, 本郷 文弥, 高羽 夏樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 239 -239 2011年03月 [無し][無し]
  • アンドロゲン受容体転写抑制因子を介した精巣腫瘍発生の分子機構の解析
    上田 崇, 伊藤 紗弥, 中村 晃和, 高羽 夏樹, 河内 明宏, 武山 健一, 三木 恒治, 加藤 茂明 日本泌尿器科学会雑誌 102 (2) 262 -262 2011年03月 [無し][無し]
  • 超高速MRIを用いた勃起時における陰茎内の形態学的変化と動脈流入量の検討
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 鴨井 和実, 藤原 光文, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 286 -286 2011年03月 [無し][無し]
  • 腎細胞癌におけるhigh mobility group protein AT-hook 1(HMGA1)の発現と役割に関する検討
    高羽 夏樹, 竹内 一郎, 曽和 義広, 木村 泰典, 中村 晃和, 本郷 文弥, 三神 一哉, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 294 -294 2011年03月 [無し][無し]
  • 酪酸菌によるTRAIL誘導とその膀胱癌治療への応用に関する検討
    神農 雅秀, 堀中 真野, 木村 泰典, 中村 晃和, 本郷 文弥, 三神 一哉, 高羽 夏樹, 河内 明宏, 酒井 敏行, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 301 -301 2011年03月 [無し][無し]
  • ホルモン不応前立腺癌における抗肥満薬orlistatとTRAILの併用効果の検討
    藤原 淳, 曽和 義広, 神農 雅秀, 山田 剛司, 大石 正勝, 木村 泰典, 中村 晃和, 本郷 文弥, 三神 一哉, 高羽 夏樹, 河内 明宏, 酒井 敏行, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 311 -311 2011年03月 [無し][無し]
  • 去勢抵抗性前立腺癌患者の予後予測因子と二次内分泌療法および抗がん剤を用いた治療効果の検討
    鴨井 和実, 沖原 宏治, 高羽 夏樹, 岩田 健, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 318 -318 2011年03月 [無し][無し]
  • 進行性精巣腫瘍の化学療法後残存腫瘍に対する腹腔鏡下後腹膜リンパ節郭清(Lap RPLND)の初期経験
    木村 泰典, 中村 晃和, 河内 明宏, 三神 一哉, 山田 剛司, 本郷 文弥, 高羽 夏樹, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 349 -349 2011年03月 [無し][無し]
  • 夜尿症児に対する抗コリン剤の治療効果
    石田 博万, 内藤 泰行, 邵 仁哲, 鴨井 和実, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 390 -390 2011年03月 [無し][無し]
  • 当科における体腔鏡下腎部分切除術の経験と最近の手技
    金沢 元洪, 本郷 文弥, 納谷 佳男, 伊藤 吉三, 内藤 泰行, 邵 仁哲, 鴨井 和実, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 399 -399 2011年03月 [無し][無し]
  • 当院における腎部分切除術の臨床的検討
    南口 尚紀, 針貝 俊治, 清水 輝記, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 406 -406 2011年03月 [無し][無し]
  • 5α-reductase inhibitor(Dutasteride)とα遮断剤併用療法の有効性の検討
    林 一誠, 鴨井 和実, 沖原 宏治, 稲垣 哲典, 藤原 敦子, 岩田 健, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 443 -443 2011年03月 [無し][無し]
  • 透析導入前に腎摘除術の既往がある15例の臨床的検討
    奥原 紀子, 大西 彰, 平山 きふ, 関 英夫, 小山 正樹, 今田 直樹, 青木 正, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 467 -467 2011年03月 [無し][無し]
  • 前立腺癌細胞のホルモン不応性獲得におけるhigh mobility group protein AT-hook 1(HMGA1)のin vitroおよびin vivoにおける役割についての検討
    竹内 一郎, 高羽 夏樹, 林 一誠, 木村 泰典, 岩田 健, 中村 晃和, 本郷 文弥, 三神 一哉, 鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 489 -489 2011年03月 [無し][無し]
  • 高齢者(75歳以上)去勢抵抗性前立腺癌に対するドセタキセル化学療法の臨床成績
    山田 剛司, 高羽 夏樹, 沖原 宏治, 鴨井 和実, 岩田 健, 河内 明宏, 南口 尚紀, 矢野 公大, 伊藤 吉三, 米田 公彦, 大嶺 卓司, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 496 -496 2011年03月 [無し][無し]
  • 小切開根治的前立腺全摘除術の治療成績
    牛嶋 壮, 沖原 宏治, 山田 剛司, 藤原 敦子, 鴨井 和実, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 501 -501 2011年03月 [無し][無し]
  • 経直腸超音波断層法を使用したマウス残尿測定の有用性
    平原 直樹, 浮村 理, 林 一誠, 藤原 敦子, 鴨井 和実, 河内 明宏, 松井 稔, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 504 -504 2011年03月 [無し][無し]
  • 本城 久司, 中尾 昌宏, 上山 純, 近藤 高明, 浜島 信之, 鴨井 和実, 浮村 理, 河内 明宏, 北小路 博司, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 504 -504 2011年03月 [無し][無し]
  • 最新の前立腺癌罹患率の変化からみた前立腺癌検診の妥当性
    岩田 健, 鴨井 和実, 鳴川 司, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 102 (2) 545 -545 2011年03月 [無し][無し]
  • 前立腺がん検診ガイドライン「一次検診受診後のファクトシート」についてのアンケート調査
    北村 浩二, 藤原 淳, 井戸本 陽子, 沖原 宏治, 三神 一哉, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 19 (1) 115 -116 2011年03月 [無し][無し]
  • 我が国における前立腺がん住民検診の年齢上限設定の現況 前立腺がん検診研究班(田中班)、年次報告書からの考察
    沖原 宏治, 三神 一哉, 鴨井 和実, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 18 (3) 190 -192 2011年02月 [無し][無し]
     
    平成16・17年度前立腺がん検診研究班(田中班)、年次報告書から、我が国における前立腺がん住民検診の年齢上限設定に関する考察を行った。市町村単位の年齢階層別の前立腺がん検診受診人数から80歳以上の受診の有無を算定した。平成16・17年度の80歳以上の受診者がいない割合は、大きな差異を認めず、それぞれ7〜8%、7〜10%と算定された。本結果は、あくまでも各市町村に検診の年齢設定を直接聴取したものではないので概算であることは否めないが、現時点で90%以上の市町村が年齢上限限界を設定していないことが推察された。(著者抄録)
  • 京都府乙訓前立腺がん検診15年間の高齢者受診状況
    北村 浩二, 藤原 淳, 井戸本 陽子, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 18 (3) 225 -227 2011年02月 [無し][無し]
     
    検診受診者のうち85歳以上の占める割合は4%とそれほど多くはなかった。しかし生検を行えばその36%に前立腺がんが見つかった。生検の適応や発見前立腺がん症例に対する治療は責任医師の判断で行っているが、内分泌療法を開始する症例が多い傾向にあった。検診を受けるかどうかは本来受診者の自由意志であり、また受診者において高齢者の占める割合もそれほど多くはないことから、前立腺がん検診における年齢上限の設定は必ずしも必要ではないと思われる。高齢者の受診者に対しては受診者本人や家族の意義、PSA値などを参考に、責任医師の判断で前立腺針生検の適応を考えるのが、現時点では妥当と思われる。(著者抄録)
  • 急性巨核芽球性白血病を併発した縦隔原発性腺外胚細胞腫の1例
    上野 彰久, 中村 晃和, 松ヶ角 透, 木村 泰典, 藤原 敦子, 内藤 泰行, 河内 明宏, 三木 恒治, 稲葉 亨 泌尿器科紀要 57 (2) 104 -104 2011年02月 [無し][無し]
  • 限局性膀胱アミロイドーシスの1例
    松ヶ角 透, 鴨井 和実, 針貝 俊治, 木村 泰典, 平原 直樹, 邵 仁哲, 河内 明宏, 三木 恒治 泌尿器科紀要 57 (2) 110 -110 2011年02月 [無し][無し]
  • 術前診断が困難であった後腹膜腫瘍の1例
    大橋 宗洋, 本郷 文弥, 上野 彰久, 藤原 敦子, 岩田 健, 中村 晃和, 三神 一哉, 高羽 夏樹, 河内 明宏, 三木 恒治 泌尿器科紀要 57 (2) 112 -112 2011年02月 [無し][無し]
  • 【低侵襲手術・機能温存手術の最前線】 泌尿器科領域における単孔式腹腔鏡手術
    河内 明宏, 三木 恒治 京都府立医科大学雑誌 120 (2) 75 -80 2011年02月 [無し][無し]
     
    腹腔鏡手術は低侵襲療法の一つとして発展し,多くの疾患に対する標準的治療法となっている.この領域において単孔式腹腔鏡手術が新しく開発され,最近報告が急速に増加している.単孔式腹腔鏡手術とは単一の小切開に器具を挿入し行う腹腔鏡手術で,多くの場合,臍部の1.5cm〜2.5cm程度の切開で行われるため,術後はほとんど傷が目立たず,「Scarless surgery」に最も近い術式である.本邦では2008年に最初の症例として,当科において精索静脈瘤根治術が行われ,その後,副腎摘除術,腎盂形成術,腎摘除術,前立腺全摘除術などが報告されている.本稿ではその術式および当科における手術成績を中心に泌尿器科領域の単孔式腹腔鏡手術につき概説する.(著者抄録)
  • 多発性脊椎骨折を契機に発見された副腎性Cushing症候群の1例 附 当科における体腔鏡下副腎手術
    山田 恭弘, 矢野 公大, 篠田 康夫, 平原 直樹, 大江 宏, 伊藤 吉三, 河内 明宏, 尾立 征一, 竹村 俊樹 京都第二赤十字病院医学雑誌 31 75 -79 2010年12月 [無し][無し]
     
    Cushing症候群では高い頻度で骨粗鬆症を合併し、その加療中にしばしば病的骨折を合併することが知られている。しかし骨折が先行しCushing症候群が検出される例は比較的少ない。今回われわれは脊椎の多発性骨折を契機に発見され、体腔鏡下手術により腺腫を摘除し加療した36歳女性にみられた左副腎原発性Cushing症候群の1例を経験した。当科では最近8年間に111例の体腔鏡手術を実施しているが、副腎への応用は2003年より開始しこれまでに19例(体腔鏡下手術の17.1%)の手術を施行している。これは腎摘除43例(38.7%)、腎尿管全摘除39例(35.1%)に次いで多い。泌尿器科分野の体腔鏡下手術はこの3者によりほぼ3分され構成されていることが理解された。(著者抄録)
  • 維持透析患者のレストレスレッグス症候群に対する診断と治療
    橋本 哲也, 河内 明宏, 小野 利彦, 岩元 則幸 日本透析医会雑誌 25 (3) 484 -490 2010年12月 [無し][無し]
     
    透析患者にrestless legs syndrome(以下RLS)が合併することは古くより知られているが、未だ透析医療に従事する医師やスタッフに十分に認知されているとは思われない。しかし、多くの報告でその有病率は20%以上とされており、RLSを合併した透析患者は日常診療の中で抱かれているイメージよりはるかに多いものと思われる。また、RLSは透析患者の不眠の原因になるばかりかQOLを低下させる原因にもなっており、本疾患につき理解を深めることは透析医療に従事する者にとって肝要である。そこで、透析患者に合併したRLSの疫学・診断・治療について自験例もふまえ報告したい。(著者抄録)
  • ED基礎研究から新しい治療法への提言 糖尿病性EDの本質とは? ED基礎研究から見えてくるもの
    邵 仁哲, 内藤 泰行, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文, 落合 厚 日本性機能学会雑誌 25 (3) 279 -279 2010年12月 [無し][無し]
  • Peyronie病に対するニカルジピンvs.生理食塩水局所注入療法の検討 A prospective,Randomised,Single-Blind Trial
    邵 仁哲, 内藤 泰行, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文, 落合 厚 日本性機能学会雑誌 25 (3) 283 -283 2010年12月 [無し][無し]
  • わが国における前立腺がん住民検診の年齢上限設定に関する考察
    沖原 宏治, 三神 一哉, 鴨井 和実, 河内 明宏, 三木 恒治 日本老年泌尿器科学会誌 23 58 -58 2010年11月 [無し][無し]
  • 高齢者EDの検討(EDの予防の観点から)
    邵 仁哲, 兼光 紀幸, 落合 厚, 納谷 佳男, 内藤 泰行, 鴨井 和実, 河内 明宏, 藤原 光文, 三木 恒治 日本老年泌尿器科学会誌 23 96 -96 2010年11月 [無し][無し]
  • 当院女性泌尿器外来における高齢者に対する骨盤底筋体操指導の効果について
    釜子 優美子, 藤原 敦子, 問山 大輔, 岩田 健, 沖原 宏治, 河内 明宏, 三木 恒治 日本老年泌尿器科学会誌 23 111 -111 2010年11月 [無し][無し]
  • 腹腔鏡下腎部分切除術の断端止血における新規医療用接着剤(LYDEX)の有用性
    内藤 泰行, 河内 明宏, 邵 仁哲, 中島 直喜, 玄 丞烋, 三木 恒治 人工臓器 39 (2) S129 -S129 2010年11月 [無し][無し]
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    中村 晃和, 河内 明宏, 山上 卓士, 平岡 健児, 藤原 淳, 木村 泰典, 本郷 文弥, 三神 一哉, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 100 -100 2010年10月 [無し][無し]
  • 単孔式腹腔鏡手術(LESS) Laparo-endoscopic single-site surgery(LESS)の経験
    河内 明宏, 内藤 泰行, 鴨井 和実, 邵 仁哲, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 120 -120 2010年10月 [無し][無し]
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    本郷 文弥, 河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 154 -154 2010年10月 [無し][無し]
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    木村 泰典, 中村 晃和, 河内 明宏, 川端 岳, 三神 一哉, 本郷 文弥, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 198 -198 2010年10月 [無し][無し]
  • 腹腔鏡下手術にて摘出した副腎外褐色細胞腫の一例
    鳥山 清二郎, 阿部 弘一, 稲葉 光彦, 奥原 紀子, 佐藤 暢, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 199 -199 2010年10月 [無し][無し]
  • 腫瘍蒸散のための形状記憶合金を用いた蒸散プローブの研究
    内藤 泰行, 河内 明宏, 邵 仁哲, 鴨井 和実, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 216 -216 2010年10月 [無し][無し]
  • 前立腺全摘除術における機能温存手技の標準化
    鴨井 和実, 沖原 宏治, 岩田 健, 藤原 敦子, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (3) 253 -253 2010年10月 [無し][無し]
  • 各領域における単孔式内視鏡手術の適応拡大 泌尿器科領域におけるLaparoendoscopic Single Site Surgery(LESS)
    河内 明宏, 鴨井 和実, 内藤 泰行, 邵 仁哲, 沖原 宏治, 三木 恒治 日本内視鏡外科学会雑誌 15 (7) 201 -201 2010年10月 [無し][無し]
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    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本内視鏡外科学会雑誌 15 (7) 278 -278 2010年10月 [無し][無し]
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    本郷 文弥, 河内 明宏, 中河 秀生, 内藤 泰行, 中村 晃和, 邵 仁哲, 鴨井 和実, 三神 一哉, 沖原 宏治, 三木 恒治 日本内視鏡外科学会雑誌 15 (7) 448 -448 2010年10月 [無し][無し]
  • K. Kamoi, K. Okihara, O. Ukimura, F. Hongo, Y. Naitoh, A. Kawauchi, T. Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 24 A82 -A82 2010年09月 [無し][無し]
  • Y. Naitoh, A. Kawauchi, K. Kamoi, J. Soh, K. Okihara, T. Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 24 A276 -A276 2010年09月 [無し][無し]
  • F. Hongo, A. Kawauchi, Y. Naitoh, T. Nakamura, J. Soh, K. Kamoi, K. Mikami, K. Okihara, N. Takaha, T. Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 24 A54 -A54 2010年09月 [無し][無し]
  • J. Soh, A. Kawauchi, N. Kanemitsu, Y. Naya, A. Ochiai, Y. Naitoh, T. Fujiwara, K. Kamoi, T. Miki JOURNAL OF SEXUAL MEDICINE 研究発表ペーパー・要旨(国際会議) 7 231 -231 2010年09月 [無し][無し]
  • Y. Naitoh, A. Kawauchi, K. Kamoi, J. Soh, K. Okihara, N. Nakajima, H. S. Hyu, T. Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 24 A11 -A11 2010年09月 [無し][無し]
  • 過活動膀胱症状を有する中高年女性における血清NOx値と平均1回排尿量との関連性
    本城 久司, 中尾 昌宏, 上山 純, 近藤 高明, 浜島 信之, 浮村 理, 河内 明宏, 北小路 博司, 三木 恒治 日本排尿機能学会誌 21 (1) 226 -226 2010年09月 [無し][無し]
  • 骨盤外科の解剖と各領域の実際 前立腺全摘除術における機能温存手技の標準化
    鴨井 和実, 沖原 宏治, 河内 明宏, 三木 恒治 日本癌治療学会誌 45 (2) 420 -420 2010年09月 [無し][無し]
  • がんの局所療法 泌尿器がんに対するラジオ波焼灼療法
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  • 早期前立腺がんの治療戦略 スクリーニングで診断された早期癌に対する治療の現状
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  • ホルモン抵抗性前立腺癌に対するドセタキセルによる化学療法の治療成績
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  • 当科におけるT1腎癌に対するハンドアシスト法根治的腎摘除術の長期予後の検討
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  • 小切開根治的前立腺全摘除術の治療成績
    山田 剛司, 沖原 宏治, 藤原 敦子, 鴨井 和実, 河内 明宏, 三木 恒治 日本癌治療学会誌 45 (2) 936 -936 2010年09月 [無し][無し]
  • 前立腺癌永久挿入密封小線源療法における、総線源強度Nomogram作成の試み
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  • 進行性尿路上皮癌Unfit patient対するGemcitabine・Nedaplatin療法の経験
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  • 【小径腎腫瘍の診断と治療Update】 体腔鏡下腎部分切除におけるイメージガイダンスの有用性
    平原 直樹, 浮村 理, 本郷 文弥, 河内 明宏, 三木 恒治 Urology View 8 (4) 97 -101 2010年08月 [無し][無し]
  • Peyronie病に対するニカルジピンvs.生理食塩水局所注入療法の検討 A prospective,Randomised,Single-Blind Trial
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  • 仙髄鍼刺激による排尿機能抑制はGABA作動性ニューロンを介している(Acupuncture to the sacral segment suppresses micturition through GABAergic system)
    小山 純正, Wang Hui, 田中 善之, 河内 明宏, 三木 恒治, 香山 雪彦 神経化学 49 (2-3) 563 -563 2010年08月 [無し][無し]
  • 腎細胞癌におけるHMGA1の発現に関する検討(Expression of high mobility group protein AT-hook 1 (HMGA1) in renal cell carcinoma)
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  • 前立腺癌細胞のホルモン不応性獲得におけるhigh mobility group protein AT-hook 1(HMGA1)の役割についての検討(HMGA1 is associated with the development of androgen independency in prostate cancer cells)
    竹内 一郎, 高羽 夏樹, 林 一誠, 木村 泰典, 岩田 健, 中村 晃和, 本郷 文弥, 鴨井 和実, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本癌学会総会記事 69回 473 -473 2010年08月 [無し][無し]
  • 京都府健診事業評価調査による、前立腺がん検診におけるドック検診・病院検診の現状
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  • 京都府乙訓前立腺がん検診15年間の高齢者受診状況
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  • わが国における前立腺がん住民検診の年齢上限設定の現況 前立腺がん検診研究班(田中班)、年次報告書からの考察
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  • 同一ポートで腹腔鏡下腎摘除術と消化器外科手術を行った2例
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  • 治療前後での夜尿症児とその母親のHealth Related Quality of lifeの検討
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  • 糖尿病におけるEDの発症機序 血管内皮機能を中心に
    邵 仁哲, 内藤 泰行, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文, 落合 厚 日本性機能学会雑誌 25 (1) 68 -69 2010年06月 [無し][無し]
  • 夜尿症児に対する第三選択としての抗コリン剤の治療効果
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  • 夜間多尿の夜尿児に対するDDAVP療法とアラーム療法の検討
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  • 小児泌尿器科疾患に対する腹腔鏡手術とその適応 経膀胱的体腔鏡下逆流防止術(Cohen法)の適応と治療成績
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 19 (2) 115 -115 2010年05月 [無し][無し]
  • 小児泌尿器科疾患に対する腹腔鏡手術とその適応 小児泌尿器科疾患に対するLaparoendoscopic Single-site Surgery(LESS)の経験
    河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 三木 恒治 日本小児泌尿器科学会雑誌 19 (2) 118 -118 2010年05月 [無し][無し]
  • 夜尿症児に対する第三選択としての抗コリン剤の効果
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 19 (2) 140 -140 2010年05月 [無し][無し]
  • Jintetsu Soh, Y. Naya, A. Ochiai, Y. Naito, K. Yoneda, N. Kanemitsu, A. Kawauchi, T. Miki JOURNAL OF SEXUAL MEDICINE 研究発表ペーパー・要旨(国際会議) 7 82 -83 2010年04月 [無し][無し]
  • Hisashi Honjo, Masahiro Nakao, Jun Ueyama, Takaaki Kondo, Osamu Ukimura, Akihiro Kawauchi, Hiroshi Kitakoji, Nobuyuki Hamajima, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 183 (4) E588 -E589 2010年04月 [無し][無し]
  • Daisuke Toiyama, Natsuki Takaha, Jun Fujiwara, Terukazu Nakamura, Humiya Hongo, Kazuya Mikami, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 183 (4) E86 -E86 2010年04月 [無し][無し]
  • Daisuke Toiyama, Natsuki Takaha, Jun Fujiwara, Yasunori Kimura, Terukazu Nakamura, Fumiya Hongo, Kazuya Mikami, Akihiro Kawauchi, Tsuneharu Miki CANCER RESEARCH 研究発表ペーパー・要旨(国際会議) 70 2010年04月 [無し][無し]
  • Kazumi Kamoi, Osamu Ukimura, Koji Okihara, Natsuki Takaha, Tsuyoshi Iwata, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 183 (4) E361 -E361 2010年04月 [無し][無し]
  • Daisuke Toiyama, Natsuki Takaha, Jun Fujiwara, Yasunori Kimura, Terukazu Nakamura, Fumiya Hongo, Kazuya Mikami, Akihiro Kawauchi, Tsuneharu Miki CANCER RESEARCH 研究発表ペーパー・要旨(国際会議) 70 2010年04月 [無し][無し]
  • 前立腺肉腫と鑑別困難であった直腸GIST(gastrointestinal stromal tumor)の1例
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  • 矢野 公大, 堀中 真野, 吉田 達士, 安田 考志, 谷口 浩也, Goda Ahmed, 中村 晃和, 河内 明宏, 三木 恒治, 酒井 敏行 日本衛生学雑誌 65 (2) 285 -285 2010年04月 [無し][無し]
  • 【小児の腹腔鏡下手術】 膀胱尿管逆流症
    内藤 泰行, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (1) 53 -57 2010年04月 [無し][無し]
  • 【長期成績 腎癌】 T1腎癌に対するハンドアシスト法根治的腎摘除術の長期予後について
    本郷 文弥, 河内 明宏, 加藤 峰之, 内藤 泰行, 中村 晃和, 邵 仁哲, 鴨井 和実, 三神 一哉, 沖原 宏治, 高羽 夏樹, 鈴木 啓, 中内 博夫, 金沢 元洪, 佐藤 暢, 増田 健人, 南口 尚紀, 田中 善之, 伊藤 吉三, 大嶺 卓司, 今田 直樹, 高田 仁, 米田 公彦, 北村 浩二, 藤戸 章, 宮下 浩明, 前川 幹雄, 野々村 光生, 三木 恒治 Japanese Journal of Endourology and ESWL 23 (1) 68 -71 2010年04月 [無し][無し]
     
    1999年11月より2008年11月までにハンドアシスト法を用いた後腹膜鏡下腎摘除術をT1腎癌132例(以下HALS-Nx群)に対して行った。その予後について61例の開腹腎摘除術(以下OPEN-Nx群)と比較検討した。手術時間は両群で有意差はなく、出血量はHALS-Nx群で有意に少なかった。観察期間はHALS-Nx群は6-119ヵ月(中央値65ヵ月)。OPEN-Nx群は7-146ヵ月(中央値84ヵ月)であった。5年非再発率はHALS-Nx群で93.9%、OPEN-Nx群93.4%であった。非再発率の推移をKaplan-Meier法を用いて算出したところ、両群間に有意差を認めなかった。また、癌特異的5年生存率はHALS-Nx群で95.5%、OPEN-Nx群94.3%であり、両群間で有意差を認めなかった。癌制御という点でHALS-Nxは開腹手術と比べて遜色ないものと考えられた。(著者抄録)
  • バルーン法エラストグラフィによる前立腺癌診断
    落合 厚, 沖原 宏治, 浮村 理, 鴨井 和実, 本郷 文弥, 河内 明宏, 三木 恒治 超音波医学 37 (2) 210 -210 2010年03月 [無し][無し]
  • Castleman病の1例
    新納 摩子, 邵 仁哲, 山田 剛司, 平原 直樹, 浮村 理, 河内 明宏, 三木 恒治, 荒木 博孝, 中河 裕治, 井上 亘, 小林 徳朗 泌尿器科紀要 56 (3) 191 -191 2010年03月 [無し][無し]
  • 京都府乙訓地区前立腺がん検診における、再生検適応因子の再考
    平山 きふ, 北村 浩二, 井戸本 陽子, 岡田 晃一, 三神 一哉, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 17 (3) 236 -238 2010年03月 [無し][無し]
     
    京都府乙訓地域では前立腺がん検診を、1995年から行っている。一次健診として前立腺がんの腫瘍マーカーである前立腺特異抗原(PSA)を測定し、カットオフ値は4.0ng/mlで行っている。二次検診は直腸診、経直腸的超音波断層法を施行した上で、要精検者に対し局所麻酔下に経会陰的前立腺生検(8ヶ所生検)を行っている。今回再生検症例140例を解析したところ、50例に前立腺がんを認めた。PSA gray zoneでDRE・TRUSで異常所見を認めず、PSADが0.15以上であっても前立腺体積が30ml以上の場合を経過観察とすると、さらに41例の生検を回避することができる。がんの見逃しは7例となるが、そのほとんどがlow riskがんであり、年1回の検診受診を勧めた上で、前立腺体積も再生検の適応因子に入れた方が今後の検診を進める上でより効率的となりうるのではないかと思われた。(著者抄録)
  • 前立腺がん検診で見つかった病気
    北村 浩二, 井戸本 陽子, 三神 一哉, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 18 (1) 63 -64 2010年03月 [無し][無し]
  • アルコール摂取量と勃起障害(ED)に関する検討
    兼光 紀幸, 邵 仁哲, 内藤 泰行, 落合 厚, 納谷 佳男, 米田 公彦, 河内 明宏, 藤原 光文, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 18 (1) 81 -83 2010年03月 [無し][無し]
  • 成人の停留精巣に発見された精巣腫瘍の1例
    新納 摩子, 内藤 泰行, 山田 剛司, 中村 晃和, 沖原 宏治, 水谷 陽一, 河内 明宏, 三木 恒治 泌尿器科紀要 56 (2) 132 -132 2010年02月 [無し][無し]
  • 成人の尿道上裂に発生した尿道癌の1例
    神農 雅秀, 内藤 泰行, 新納 摩子, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治, 井上 亘 泌尿器科紀要 56 (2) 139 -139 2010年02月 [無し][無し]
  • 腎腫瘍に対する低侵襲療法
    河内 明宏 日本泌尿器科学会雑誌 101 (2) 78 -78 2010年02月 [無し][無し]
  • LOH症候群診療の手引き LOH症候群の合併症
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 米田 公彦, 河内 明宏, 藤原 光文, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 99 -99 2010年02月 [無し][無し]
  • 近未来の泌尿器科手術 近未来低侵襲手術としてのLaparoendoscopic Single Site Surgery(LESS)
    河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 121 -121 2010年02月 [無し][無し]
  • Laparoendoscopic Single Site Surgery(LESS)の経験
    河内 明宏, 内藤 泰行, 鴨井 和実, 邵 仁哲, 沖原 宏治, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 167 -167 2010年02月 [無し][無し]
  • 超高速MRIを用いた勃起時の動的画像解析
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 河内 明宏, 藤原 光文, 東 高志, 中井 隆介, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 172 -172 2010年02月 [無し][無し]
  • 早期前立腺がんに対する局所療法の適応例選択におけるMRIガイド下選択生検の有用性の検討
    鴨井 和実, 沖原 宏治, 岩田 健, 平原 直樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 193 -193 2010年02月 [無し][無し]
  • 腎尿管全摘除術300例の手術成績と予後
    廣田 英二, 河内 明宏, 鴨井 和美, 平原 直樹, 邵 仁哲, 内藤 泰行, 藤戸 章, 宮下 浩明, 伊達 成基, 荒木 博孝, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 204 -204 2010年02月 [無し][無し]
  • 体腔鏡下腎部分切除術の手術成績に関与する術前因子の検討
    藤井 秀岳, 鴨井 和実, 中村 晃和, 内藤 泰行, 本郷 文弥, 邵 仁哲, 三神 一哉, 高羽 夏樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 215 -215 2010年02月 [無し][無し]
  • 新規医療用接着剤(LYDEX)の腹腔鏡下腎部分切除術における有用性
    内藤 泰行, 河内 明宏, 邵 仁哲, 中島 直樹, 玄 丞烋, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 216 -216 2010年02月 [無し][無し]
  • 当科における体腔鏡下腎盂形成術の治療成績
    大石 正勝, 内藤 泰行, 邵 仁哲, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 286 -286 2010年02月 [無し][無し]
  • 抗肥満薬orlistatのホルモン不応性前立腺癌細胞株DU145に対する抗腫瘍効果の検討とその分子機構の解明
    藤原 淳, 曽和 義広, 神農 雅秀, 山田 剛司, 大石 正勝, 問山 大輔, 矢野 公大, 中村 晃和, 本郷 文弥, 三神 一哉, 河内 明宏, 酒井 敏行, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 330 -330 2010年02月 [無し][無し]
  • Stage C前立腺癌の内分泌単独治療成績 stage Bとの生存率の比較
    問山 大輔, 沖原 宏治, 竹内 一郎, 藤原 淳, 石田 博万, 大石 正勝, 浮村 理, 高羽 夏樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 335 -335 2010年02月 [無し][無し]
  • 再燃前立腺癌に対するドセタキセルによる化学療法の成績
    高羽 夏樹, 沖原 宏治, 岩田 健, 本郷 文弥, 鴨井 和実, 河内 明宏, 南口 尚紀, 伊藤 吉三, 米田 公彦, 大嶺 卓司, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 337 -337 2010年02月 [無し][無し]
  • アンドロゲン非依存性前立腺癌細胞PC3において細胞内クロライドイオンは増殖調節因子として作用する
    平岡 健児, 沖原 宏治, 浮村 理, 高羽 夏樹, 河内 明宏, 宮崎 裕明, 新里 直美, 丸中 良典, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 373 -373 2010年02月 [無し][無し]
  • 前立腺癌の低アンドロゲン下での細胞増殖におけるhigh mobility group protein AT-hook 1(HMGA1)の役割に関する検討
    竹内 一郎, 高羽 夏樹, 平岡 健児, 藤原 淳, 問山 大輔, 中村 晃和, 本郷 文弥, 三神 一哉, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 373 -373 2010年02月 [無し][無し]
  • 上部尿路上皮内癌(CIS)に対するBCG注入療法の検討
    矢野 公大, 三神 一哉, 木村 泰典, 中村 晃和, 本郷 文弥, 高羽 夏樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 399 -399 2010年02月 [無し][無し]
  • 進行性尿路上皮癌に対するGemcitabine、Nedaplatin併用化学療法の治療成績の検討
    清水 輝記, 三神 一哉, 本郷 文弥, 中村 晃和, 高羽 夏樹, 岩田 健, 木村 泰典, 河内 明宏, 高田 仁, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 423 -423 2010年02月 [無し][無し]
  • 当院における初回陰性症例に対する経会陰的前立腺多数ヶ所生検の臨床的検討
    平原 直樹, 沖原 宏治, 岩田 健, 鴨井 和実, 浮村 理, 河内 明宏, 益澤 尚子, 柳澤 昭夫, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 443 -443 2010年02月 [無し][無し]
  • VAS質問票による前立腺癌密封小線源療法後の排尿状態の評価
    牛嶋 壮, 沖原 宏治, 岩田 健, 金沢 元洪, 内藤 泰行, 鴨井 和実, 浮村 理, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 450 -450 2010年02月 [無し][無し]
  • 小さな腎癌に対する治療選択
    神農 雅秀, 河内 明宏, 内藤 泰行, 中村 晃和, 邵 仁哲, 本郷 文弥, 鴨井 和実, 三神 一哉, 沖原 宏治, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 458 -458 2010年02月 [無し][無し]
  • 本城 久司, 中尾 昌宏, 上山 純, 浜島 信之, 浮村 理, 河内 明宏, 北小路 博司, 三木 恒治 日本泌尿器科学会雑誌 101 (2) 481 -481 2010年02月 [無し][無し]
  • Yoshimasa Koyama, Hui Wang, Yoshiyuki Tanaka, Akihiro Kawauchi, Tsuneharu Miki, Yukihiko Kayama NEUROSCIENCE RESEARCH 研究発表ペーパー・要旨(国際会議) 68 E168 -E168 2010年 [無し][無し]
  • 腎盂形成術の長期成績の検討比較 当科における体腔鏡下腎盂形成術の治療成績
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本内視鏡外科学会雑誌 14 (7) 202 -202 2009年12月 [無し][無し]
  • 泌尿器科領域におけるSingle port surgeryの経験
    河内 明宏, 内藤 泰行, 邵 仁哲, 鴨井 和実, 沖原 宏治, 三木 恒治 日本内視鏡外科学会雑誌 14 (7) 344 -344 2009年12月 [無し][無し]
  • アルコール摂取量と勃起障害(ED)に関する検討
    邵 仁哲, 内藤 泰行, 米田 公彦, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 落合 厚 日本性機能学会雑誌 24 (3) 387 -388 2009年12月 [無し][無し]
  • 小児泌尿器科領域の内視鏡手術の適応と限界 経膀胱的体腔鏡下逆流防止術(Cohen法)の適応と限界
    河内 明宏, 内藤 泰行, 邵 仁哲, 平原 直樹, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 120 -120 2009年11月 [無し][無し]
  • 膀胱褐色細胞腫に対する経膀胱的体腔鏡下摘除術の経験
    邵 仁哲, 河内 明宏, 平原 直樹, 内藤 泰行, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 135 -135 2009年11月 [無し][無し]
  • Single port surgeryの経験
    河内 明宏, 内藤 泰行, 鴨井 和実, 邵 仁哲, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 152 -152 2009年11月 [無し][無し]
  • 同一ポートで腹腔鏡下腎摘除術と消化器外科手術を行った2例
    鴨井 和実, 河内 明宏, 本郷 文弥, 邵 仁哲, 内藤 泰行, 平原 直樹, 藤原 敦子, 松ヶ角 透, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 156 -156 2009年11月 [無し][無し]
  • 当科において施行した体腔鏡下腎盂形成術の治療成績
    内藤 泰行, 河内 明宏, 平原 直樹, 邵 仁哲, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 182 -182 2009年11月 [無し][無し]
  • T1a腎癌に対する治療選択についての検討
    三神 一哉, 河内 明宏, 藤原 敦子, 内藤 泰行, 中村 晃和, 邵 仁哲, 本郷 文弥, 鴨井 和実, 高羽 夏樹, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 203 -203 2009年11月 [無し][無し]
  • 腎盂尿管癌に対する鏡視下および開腹腎尿管全摘除術の臨床的検討
    平原 直樹, 河内 明宏, 鴨井 和実, 邵 仁哲, 内藤 泰行, 中村 晃和, 本郷 文弥, 三神 一哉, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 222 -222 2009年11月 [無し][無し]
  • tension-free vaginal mesh(TVM)手術における術中リアルタイムMRIナビゲーション法の開発
    藤原 敦子, 浮村 理, 邵 仁哲, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 22 (3) 235 -235 2009年11月 [無し][無し]
  • 難治性精巣腫瘍に対するRFAの治療成績
    藤原 淳, 中村 晃和, 白石 匠, 三神 一哉, 高羽 夏樹, 浮村 理, 河内 明宏, 三木 恒治, 山上 卓士, 西村 恒彦 癌と化学療法 36 (12) 2117 -2120 2009年11月 [無し][無し]
     
    緒言:近年、経皮的ラジオ波焼灼術(RFA)の適応が拡大してきており、その有効性も確立されてきている。われわれは、化学療法後に残存する難治性精巣腫瘍の転移巣(何らかの理由で手術不適)に対してRFAを施行したので、その治療成績について報告する。対象と方法:2000年11月〜2008年12月までの間に、京都府立医科大学泌尿器科において進行性・難治性精巣腫瘍に対してRFAを施行した19例、42病変を対象とした。肝転移腫瘍6例(10病変)、肺転移腫瘍13例(32病変)、年齢は中央値36歳(20〜53)、腫瘍径は中央値12mm(2〜40)であった。治療機器は、Radionics社製Cool-tip RF system(内部冷却式直針電極)を使用し、静脈麻酔または局所麻酔下で超音波あるいはCTガイド下に経皮的に腫瘍部を穿刺し、焼灼した。治療効果は造影CTまたは造影MRIを施行し、腫瘍部の造影効果の有無で判定した。腫瘍部に造影効果の残存が認められた場合は、治療を繰り返し行った。結果:現時点で評価可能症例は28病変で、複数回治療を行った症例は9病変であった。観察期間は中央値25ヵ月で、complete response(CR)と判定された症例は、RFA施行前に腫瘍マーカーが陰性化していた群(根治的目的)では12例中12例(100%)であり、マーカー陽性のままRFAを施行した群(姑息的目的)では16例中12例(75%)であった。また、腫瘍径が30mm以下の群ではCRと判定された症例が24例中24例(100%)、30mmを超える群では4例中0例(0%)であった。合併症として気胸を認めたものが9例、血胸が2例あったが、ドレーン留置などで最終的には治癒しており、周辺臓器損傷などの合併症は認められなかった。結論:RFAは、進行性・難治性精巣腫瘍に対する救済療法として新たな選択肢になる可能性があると考えられる。(著者抄録)
  • Y. Naitoh, A. Kawauchi, K. Kamoi, J. Soh, F. Hongo, T. Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 23 A335 -A335 2009年10月 [無し][無し]
  • J. Soh, A. Kawauchi, K. Kamoi, N. Hirahara, Y. Naitoh, T. Miki JOURNAL OF ENDOUROLOGY 研究発表ペーパー・要旨(国際会議) 23 A283 -A284 2009年10月 [無し][無し]
  • 【知っておきたい泌尿器科の知識 その病態と治療】 夜尿症
    河内 明宏, 内藤 泰行, 三木 恒治 小児外科 41 (10) 1107 -1111 2009年10月 [無し][無し]
  • 進行膀胱癌の治療戦略 現状と未来 Over View 転移性膀胱癌に対する治療を中心として
    三神 一哉, 中村 晃和, 本郷 文弥, 高羽 夏樹, 河内 明宏, 三木 恒治 日本癌治療学会誌 44 (2) 261 -261 2009年09月 [無し][無し]
  • 腎凍結療法の長期予後
    鴨井 和実, 河内 明宏, 沖原 宏治, 本郷 文弥, 三神 一哉, 邵 仁哲, 中村 晃和, 内藤 泰行, 三木 恒治, Inderbir Gill 日本癌治療学会誌 44 (2) 458 -458 2009年09月 [無し][無し]
  • 当院における局所進行前立腺癌に対する内分泌併用放射線療法107例の治療成績
    高羽 夏樹, 沖原 宏治, 鴨井 和実, 浮村 理, 河内 明宏, 小林 加奈, 山崎 秀哉, 西村 恒彦, 三木 恒治 日本癌治療学会誌 44 (2) 475 -475 2009年09月 [無し][無し]
  • 体腔鏡下腎部分切除術の手術成績に関与する術前因子の検討
    河内 明宏, 鴨井 和実, 山田 剛司, 内藤 泰行, 邵 仁哲, 本郷 文弥, 中村 晃和, 三神 一哉, 沖原 宏治, 納谷 佳男, 伊藤 吉三, 藤戸 章, 宮下 浩明, 三木 恒治 日本癌治療学会誌 44 (2) 539 -539 2009年09月 [無し][無し]
  • 腎盂尿管癌に対する鏡視下および開腹腎尿管全摘除術の臨床的検討
    平原 直樹, 河内 明宏, 鴨井 和実, 邵 仁哲, 内藤 泰行, 中村 晃和, 本郷 文弥, 三神 一哉, 納谷 佳男, 伊藤 吉三, 米田 公彦, 藤戸 章, 宮下 浩明, 荒木 博孝, 三木 恒治 日本癌治療学会誌 44 (2) 762 -762 2009年09月 [無し][無し]
  • 経膀胱的体腔鏡下逆流防止術の治療成績
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 18 (2) 139 -139 2009年09月 [無し][無し]
  • 小児泌尿器科疾患に対する体腔鏡下手術の経験と新しい取り組み
    河内 明宏, 内藤 泰行, 邵 仁哲, 平原 直樹, 北森 伴人, 三木 恒治 日本小児泌尿器科学会雑誌 18 (2) 140 -140 2009年09月 [無し][無し]
  • Convenience voidが過活動膀胱症状におよぼす影響
    本城 久司, 浮村 理, 日野 こころ, 岡田 晃一, 河内 明宏, 北小路 博司, 中尾 昌宏, 三木 恒治 日本排尿機能学会誌 20 (1) 150 -150 2009年09月 [無し][無し]
  • 無麻酔マウスに対する細径超音波プローブを用いた経直腸的超音波残尿測定の有用性
    平原 直樹, 浮村 理, 林 一誠, 藤原 敦子, 岩田 健, 沖原 宏治, 河内 明宏, 三木 恒治 日本排尿機能学会誌 20 (1) 175 -175 2009年09月 [無し][無し]
  • 京都府乙訓地区前立腺がん検診における、再生検適応因子の再考
    平山 きふ, 北村 浩二, 井戸本 陽子, 岡田 晃一, 三神 一哉, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 17 (2) 128 -128 2009年09月 [無し][無し]
  • 【小児泌尿器科診療の焦点】 夜尿症の診療ガイドライン
    河内 明宏, 内藤 泰行, 三木 恒治 Urology View 7 (4) 64 -69 2009年08月 [無し][無し]
  • 超高速MRIを用いた勃起時の動的画像解析
    邵 仁哲, 東 高志, 中井 隆介, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 24 (2) 235 -236 2009年08月 [無し][無し]
  • アルコール摂取量と勃起障害(ED)に関する検討
    兼光 紀幸, 邵 仁哲, 内藤 泰行, 落合 厚, 納谷 佳男, 米田 公彦, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 24 (2) 240 -240 2009年08月 [無し][無し]
  • chetominは泌尿器癌細胞においてXIAPの分解を誘導しTRAIL感受性を増強する(Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells)
    矢野 公大, 堀中 真野, 吉田 達士, 安田 考志, 谷口 浩也, Goda Ahmed, 中村 晃和, 河内 明宏, 三木 恒治, 酒井 敏行 日本癌学会総会記事 68回 52 -52 2009年08月 [無し][無し]
  • 進行性尿路上皮癌に対するGemcitabine(GEM)/Nedaplatin(CDGP)併用化学療法の検討
    阿部 弘一, 三神 一哉, 水谷 陽一, 安田 考志, 中村 晃和, 河内 明宏, 三木 恒治, 山田 恭弘, 岩田 健, 白石 匠, 鴨井 和実 泌尿器科紀要 55 (7) 460 -460 2009年07月 [無し][無し]
  • 両側非触知精巣に対して腹腔鏡下精巣固定術を施行した1例
    清水 輝記, 内藤 泰行, 邵 仁哲, 河内 明宏, 三木 恒治 日本小児泌尿器科学会雑誌 18 (1) 72 -74 2009年07月 [無し][無し]
     
    3歳4ヵ月男児。患者は両側非触知精巣を主訴とした。紹介医からhCGテストの結果が陽性であったとの情報提供があり、腹腔内精巣と予想された。腹腔鏡検査で両側ともに内鼠径輪部に精巣を認めたため、腹腔内精巣と診断された。引き続き腹腔鏡下精巣固定術を施行し、両側ともに精巣を陰嚢内に固定した。手術時間は3時間35分で出血は微量であった。尚、術中合併症は認めず、経過良好で術後2日目に退院となった。目下、術後1年経過で、精巣の萎縮は認められていない。
  • 難治性夜尿症
    河内 明宏, 内藤 泰行, 平原 直樹, 邵 仁哲, 三木 恒治 夜尿症研究 14 11 -15 2009年06月 [無し][無し]
  • 夜尿アラーム療法
    河内 明宏, 内藤 泰行, 平原 直樹, 邵 仁哲, 三木 恒治 夜尿症研究 14 65 -69 2009年06月 [無し][無し]
  • アルコール摂取量と勃起障害(ED)に関する検討
    邵 仁哲, 内藤 泰行, 米田 公彦, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 落合 厚 日本性機能学会雑誌 24 (1) 92 -93 2009年06月 [無し][無し]
  • 治療経過に伴う夜尿症児とその母親のQOLの検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 20回 25 -25 2009年06月 [無し][無し]
  • 夜尿症治療の体系化 当科における夜尿症治療体系
    河内 明宏, 内藤 泰行, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 20回 41 -41 2009年06月 [無し][無し]
  • Y. Mizutani, Y. Li, T. Shiraishi, T. Nakamura, K. Mikami, K. Okihara, N. Takaha, O. Ukimura, A. Kawauchi, T. Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 27 (15) 2009年05月 [無し][無し]
  • K. Okihara, I. Takeuchi, O. Ukimura, N. Takaha, A. Kawauchi, T. Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 27 (15) 2009年05月 [無し][無し]
  • Akihiro Kawauchi, Yasuyuki Naitoh, Jintetsu Soh, Naoki Hirahara, Koji Okihara, Osamu Ukimura, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 181 (4) 463 -464 2009年04月 [無し][無し]
  • Atsuko Fujihara, Osamu Ukimura, Yasuhiro Yamada, Jun Fujiwara, Soh Ushijima, Koji Okihara, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 181 (4) 91 -92 2009年04月 [無し][無し]
  • Yasuyuki Naitoh, Akihiro Kawauchi, Jintetsu Soh, Koji Okihara, Osamu Ukimura, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 181 (4) 826 -826 2009年04月 [無し][無し]
  • Hisashi Honjo, Masahiro Nakao, Hiroshi Kitakoji, Koji Suzuki, Nobuyuki Hamajima, Osamu Ukimura, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 181 (4) 674 -675 2009年04月 [無し][無し]
  • 【各科領域における低侵襲・機能温存手術の現状と今後の展望】 腎癌に対する低侵襲・機能温存療法
    河内 明宏, 三木 恒治 京都府立医科大学雑誌 118 (4) 181 -187 2009年04月 [無し][無し]
     
    限局性腎癌に対しての標準的治療法として体腔鏡下根治的腎摘除術は広く行われるようになってきた.さらに低侵襲で腎機能温存が可能である治療法として体腔鏡下腎部分切除術と経皮的局所療法がある.体腔鏡下腎部分切除術は腎癌を数ミリの正常腎実質を周囲につけて切除する方法であり,技術的な難易度の高い手術法であるが,腎機能が温存できるとともに小さな傷で痛みも少なく,開腹術と同等以上の手術結果を得ることができる,優れた方法であると考えられた.また,経皮的ラジオ波焼灼術は手術・麻酔リスクのある患者に対しても局所麻酔下に施行することが可能な代替療法である.これらの治療法の選択において低侵襲・腎機能温存療法が増加してきている.本稿ではこのような最近の状況と当科での経験を中心に報告する.(著者抄録)
  • 原発性精巣カルチノイドの1例
    山田 剛司, 中村 晃和, 三神 一哉, 細田 光洋, 藤原 敦子, 金沢 元洪, 内藤 泰行, 邵 仁哲, 沖原 宏治, 浮村 理, 高羽 夏樹, 水谷 陽一, 河内 明宏, 三木 恒治 泌尿器科紀要 55 (3) 169 -169 2009年03月 [無し][無し]
  • 【腹腔鏡手術での血管処理について】 腎癌に対するハンドアシスト法
    河内 明宏, 邵 仁哲, 内藤 泰行, 平原 直樹, 沖原 宏治, 浮村 理, 三木 恒治 腎移植・血管外科 20 (2) 71 -75 2009年03月 [無し][無し]
     
    腎癌に対するハンドアシスト法(HALS)は体腔鏡下根治的腎摘除術や部分切除術において難易度の高い症例やトラブル処理に有用である。一方で、ブラインドでの操作が多くなったり、操作腔に手を入れることにより逆に手術操作が難しくなる可能性もある。このHALSには経腹膜アプローチと後腹膜アプローチが報告されている。その手術法と血管を扱う際のポイントについて概説した。(著者抄録)
  • 前立腺がん検診の現状と展望 本邦における前立腺がん検診の歴史と京都府乙訓地区における現状
    沖原 宏治, 北村 浩二, 三神 一哉, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 17 (1) 25 -27 2009年03月 [無し][無し]
  • 検診発見前立腺がんの前立腺全摘除術治療成績
    北村 浩二, 井戸本 陽子, 三神 一哉, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 17 (1) 87 -89 2009年03月 [無し][無し]
  • 【知っておきたい泌尿器科の知識】 腹腔鏡下手術の現況と術式
    河内 明宏, 三木 恒治 小児外科 41 (2) 194 -197 2009年02月 [無し][無し]
  • 腎癌におけるX-linked inhibitor of apoptosis protein発現の増強とそのバイオマーカーとしての臨床的重要性
    水谷 陽一, 中村 晃和, 三神 一哉, 金沢 元洪, 内藤 泰行, 邵 仁哲, 沖原 宏治, 高羽 夏樹, 浮村 理, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 129 -129 2009年02月 [無し][無し]
  • 加齢男性性腺機能低下症候群(LOH症候群)に対するアンドロゲン補充療法の治療前後における各種ホルモン値の変動に関する検討
    邵 仁哲, 兼光 紀幸, 内藤 泰行, 落合 厚, 納谷 佳男, 米田 公彦, 河内 明宏, 三木 恒治, 藤原 光文, 福井 道明, 中村 直登 日本泌尿器科学会雑誌 100 (2) 163 -163 2009年02月 [無し][無し]
  • 本城 久司, 中尾 昌宏, 鈴木 康司, 浮村 理, 河内 明宏, 北小路 博司, 浜島 信之, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 168 -168 2009年02月 [無し][無し]
  • 藤原 淳, 山田 恭弘, 牛嶋 壮, 山田 剛司, 問山 大輔, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 172 -172 2009年02月 [無し][無し]
  • クロライドイオン輸送体を分子標的とするアンドロゲン非依存性前立腺癌細胞増殖制御の試み
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  • ホルモン非依存性前立腺癌細胞株PC-3を用いたtumor necrosis factor-related apoptosis-inducing ligand(TRAIL)と併用効果を持つ薬剤の探索とその分子機構の解析
    矢野 公大, 堀中 真野, 吉田 達士, 安田 考志, 藤原 淳, 神農 雅秀, 浮村 理, 水谷 陽一, 河内 明宏, 酒井 敏行, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 220 -220 2009年02月 [無し][無し]
  • 林 一誠, 水谷 陽一, 阿部 弘一, 問山 大輔, 中村 晃和, 三神 一哉, 河内 明宏, 浦崎 晃司, 柳澤 昭夫, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 226 -226 2009年02月 [無し][無し]
  • 当院におけるT3N0M0前立腺癌に対する内分泌併用放射線療法107例の治療成績
    高羽 夏樹, 沖原 宏治, 金沢 元洪, 浮村 理, 水谷 陽一, 河内 明宏, 小林 加奈, 山崎 秀哉, 西村 恒彦, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 262 -262 2009年02月 [無し][無し]
  • 前立腺癌細胞のホルモン不応性獲得におけるhigh mobility group protein AT-hook1(HMGA1)の役割についての検討
    竹内 一郎, 高羽 夏樹, Meeker Alan, 平岡 健児, 藤原 淳, 安田 考志, 矢野 公大, 問山 大輔, 沖原 宏治, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 341 -341 2009年02月 [無し][無し]
  • アルコール摂取量と勃起障害(ED)に関する検討
    兼光 紀幸, 邵 仁哲, 内藤 泰行, 落合 厚, 納谷 佳男, 米田 公彦, 河内 明宏, 藤原 光文, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 347 -347 2009年02月 [無し][無し]
  • 体腔鏡下腎部分切除術の手術成績を左右する術前因子の検討
    河内 明宏, 山田 剛司, 内藤 泰行, 邵 仁哲, 浮村 理, 納谷 佳男, 伊藤 吉三, 藤戸 章, 宮下 浩明, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 374 -374 2009年02月 [無し][無し]
  • 腹腔鏡下腎部分切除術における新規医療用接着剤の有用性
    内藤 泰行, 河内 明宏, 邵 仁哲, 沖原 宏治, 水谷 陽一郎, 伊達 成基, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 375 -375 2009年02月 [無し][無し]
  • 腎癌症例における血清TNF related apoptosis-inducing ligand(TRAIL)値の意義
    問山 大輔, 水谷 陽一, 矢野 公大, 藤原 淳, 安田 考志, 石田 博万, 林 一誠, 平岡 健児, 神農 雅秀, 中村 晃和, 三神 一哉, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 378 -378 2009年02月 [無し][無し]
  • 山田 恭弘, 浮村 理, 藤原 淳, 藤原 敦子, 牛嶋 壮, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 385 -385 2009年02月 [無し][無し]
  • わが国における超高齢者前立腺癌患者に対する診断・治療指針の動向
    沖原 宏治, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 418 -418 2009年02月 [無し][無し]
  • 小切開恥骨後式前立腺全摘除術における術後早期尿禁制と膜様部尿道長との関連性の検討
    山田 剛司, 沖原 宏治, 神農 雅秀, 林 一誠, 金沢 元洪, 高羽 夏樹, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 100 (2) 476 -476 2009年02月 [無し][無し]
  • H. Honjo, O. Ukimura, A. Kawauchi, H. Kitakoji, M. Nakao, T. Miki NEUROUROLOGY AND URODYNAMICS 研究発表ペーパー・要旨(国際会議) 28 (7) 604 -605 2009年 [無し][無し]
  • わが国における検診発見がん患者の動向について
    沖原 宏治, 北村 浩二, 三神 一哉, 浮村 理, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 16 (3) 48 -51 2009年01月 [無し][無し]
     
    前立腺がん検診を契機に発見された前立腺癌患者のトレンドを要約した。経年的な検診の継続で検診発見癌の比率ならびに早期癌の比率は増加している。検診暴露率が高くなると、転移癌の比率は低くなる。低年齢化やPSAの動向は今後の経過観察が必要である。(著者抄録)
  • 夜尿症の病態とアラーム療法
    河内 明宏 日本医事新報 (4416) 93 -93 2008年12月 [無し][無し]
  • 腎盂・尿管腫瘍の診断における画像診断の有用性と限界
    廣田 英二, 大石 正勝, 谷口 英史, 本郷 文弥, 伊藤 吉三, 大江 宏, 前川 幹雄, 内藤 泰行, 岩田 健, 中西 弘之, 平岡 健児, 河内 明宏, 杉本 浩造, 井上 亘 京都第二赤十字病院医学雑誌 29 81 -88 2008年12月 [無し][無し]
     
    腎盂尿管腫瘍35例を腎盂腫瘍20例と尿管腫瘍15例に分類し、画像診断能についてretrospectiveに比較検討した。検討項目は、経腹的超音波断層法(US)、造影CT検査、点滴静注腎盂造影法(DIP)、逆行性腎盂造影法(RP)などの術前に行われた画像診断とした。その結果、腎盂腫瘍20例の診断率は、USが70%、造影CT検査が100%、DIPが56%、RPが100%、尿管鏡が100%で、尿細胞診検査では90%であった。尿管腫瘍15例では、USが70%、造影CT検査が60%、DIPが36%、RPが64.3%で、尿細胞診は80%であった。
  • 前立腺癌治療後のEDとその対策 前立腺全摘除術(開腹下)
    邵 仁哲, 林 一誠, 落合 厚, 内藤 泰行, 米田 公彦, 沖原 宏治, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文 日本性機能学会雑誌 23 (3) 327 -328 2008年12月 [無し][無し]
  • 2型糖尿病男性患者におけるテストステロン値の検討
    邵 仁哲, 落合 厚, 内藤 泰行, 河内 明宏, 三木 恒治, 兼光 紀幸, 納谷 佳男, 藤原 光文, 福井 道明, 中村 直登 日本性機能学会雑誌 23 (3) 331 -331 2008年12月 [無し][無し]
  • 激烈な全身症状にて発症し一期的に後腹膜鏡下両側副腎全摘除術を施行した褐色細胞腫(MEN2)の1例
    篠田 康夫, 松原 弘樹, 田原 秀一, 宮下 浩明, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 21 (4) 132 -132 2008年11月 [無し][無し]
  • 腎部分切除術における食物添加物由来の新規医療用接着剤(LYDEX)の有用性
    内藤 泰行, 河内 明宏, 邵 仁哲, 沖原 宏治, 水谷 陽一, 中島 直喜, 須賀井 一, 玄 丞烋, 伊達 成基, 三木 恒治 Japanese Journal of Endourology and ESWL 21 (4) 142 -142 2008年11月 [無し][無し]
  • 外科腹腔鏡下手術と同時に行った後腹膜鏡下腎摘除術の経験
    大石 正勝, 伊藤 吉三, 谷口 英史, 廣田 英二, 大江 宏, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 21 (4) 155 -155 2008年11月 [無し][無し]
  • 腎腫瘍に対する経皮的ラジオ波焼灼術の経験
    藤原 敦子, 藤原 淳, 平岡 健児, 河内 明宏, 浮村 理, 邵 仁哲, 水谷 陽一, 三木 恒治, 山上 卓士, 西村 恒彦 Japanese Journal of Endourology and ESWL 21 (4) 186 -186 2008年11月 [無し][無し]
  • 進行性・難治性精巣腫瘍における肺・肝転移巣に対するラジオ波焼灼術(RFA)
    三神 一哉, 中村 晃和, 高羽 夏樹, 水谷 陽一, 河内 明宏, 山上 卓士, 西村 恒彦, 三木 恒治 Japanese Journal of Endourology and ESWL 21 (4) 186 -186 2008年11月 [無し][無し]
  • 小切開恥骨後式前立腺全摘除術における術後早期尿禁制についての検討
    金沢 元洪, 沖原 宏治, 山田 剛司, 林 一誠, 牛嶋 壮, 高羽 夏樹, 浮村 理, 河内 明宏, 三木 恒治 Japanese Journal of Endourology and ESWL 21 (4) 202 -202 2008年11月 [無し][無し]
  • 体腔鏡下腎部分切除術の手術成績を左右する因子
    河内 明宏, 山田 剛司, 内藤 泰行, そう 仁哲, 浮村 理, 納谷 佳男, 伊藤 吉三, 藤戸 章, 宮下 浩明, 三木 恒治 Japanese Journal of Endourology and ESWL 21 (4) 203 -203 2008年11月 [無し][無し]
  • 血清G-CSF高値を示した腎盂原発扁平上皮癌の1例
    藤井 秀岳, 中村 晃和, 三神 一哉, 沖原 宏治, 水谷 陽一, 河内 明宏, 三木 恒治 泌尿器科紀要 54 (11) 733 -736 2008年11月 [無し][無し]
     
    67歳男。患者は左腰背部痛と尿混濁を主訴に近医を受診、腎超音波検査ならびに腹部CTにて左腎盂腫瘍が疑われ、著者らの施設へ紹介受診となった。所見ではWBC、SCC抗原、G-CSF高値が認められ、尿細胞診はclass IIであった。腹部CTでは左腎盂内から腎実質へ浸潤する充実性腫瘍がみられ、周囲脂肪織、腸腰筋浸潤も疑われた。WBCは異常高値であったが血液疾患は否定的で、感染兆候もなかった。以上より、本症例は血清G-CSF高値を伴う左腎盂扁平上皮癌と診断され、術前化学療法としてM-VAC療法が2コース施行されたが、全身倦怠感、食欲不振が続き、パクリタキセル+ネダプラチンが2クール追加施行された。その結果、SCC抗原とG-CSFはともに低下し、術前までに腫瘍は著明に縮小した。以後、左腎尿管全摘除術を施行したところ、腫瘍の大部分は壊死に陥っていた。術後は血清SCC、G-CSF値は正常化し、希望により後療法は行なわれなかったが、初診から4年以上が経過する現在、再発の兆候は認められていない。
  • Subepithelial hematomaの1例
    細田 光洋, 白石 匠, 福井 崇之, 山田 剛司, 金沢 元洪, 三神 一哉, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 泌尿器科紀要 54 (10) 694 -694 2008年10月 [無し][無し]
  • 超音波検査で偶然発見された膀胱褐色細胞腫の2例
    谷口 英史, 藤原 敦子, 邵 仁哲, 福井 崇之, 内藤 泰行, 沖原 宏治, 高羽 夏樹, 河内 明宏, 三木 恒治 泌尿器科紀要 54 (10) 696 -696 2008年10月 [無し][無し]
  • バイオマーカー研究 臨床から基礎への要望、基礎から臨床への要望 腎癌におけるX-linked inhibitor of apoptosis protein(XIAP)の発現上昇とそのバイオマーカーとしての臨床的重要性
    水谷 陽一, 中村 晃和, 三神 一哉, 高羽 夏樹, 金沢 元洪, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本癌治療学会誌 43 (2) 252 -252 2008年10月 [無し][無し]
  • がんに対する放射線治療の現状と展望 前立腺癌中間リスク症例に対する内分泌併用小線源療法のpreliminary results
    沖原 宏治, 金沢 元洪, 内藤 泰行, 水谷 陽一, 河内 明宏, 浮村 理, 小林 加奈, 山崎 秀哉, 西村 恒彦, 三木 恒治 日本癌治療学会誌 43 (2) 267 -267 2008年10月 [無し][無し]
  • 小さな腎腫瘍に対する診断と治療戦略 小さな腎腫瘍に対する低侵襲治療による治療戦略
    河内 明宏, そう 仁哲, 内藤 泰行, 中村 晃和, 三神 一哉, 高羽 夏樹, 沖原 宏治, 浮村 理, 水谷 陽一, 山上 卓士, 西村 恒彦, 三木 恒治 日本癌治療学会誌 43 (2) 288 -288 2008年10月 [無し][無し]
  • 再燃前立腺癌に対するドセタキセルの治療成績
    高羽 夏樹, 沖原 宏治, 白石 匠, 金沢 元洪, 浮村 理, 水谷 陽一, 河内 明宏, 南口 尚紀, 本郷 文弥, 伊藤 吉三, 鴨井 和実, 米田 公彦, 大嶺 卓司, 三木 恒治 日本癌治療学会誌 43 (2) 468 -468 2008年10月 [無し][無し]
  • 3次元イメージガイド手術支援システムを用いた鏡視下手術の適応拡大
    浮村 理, 中本 将彦, 佐藤 嘉伸, 沖原 宏治, 水谷 陽一, 河内 明宏, 三木 恒治 日本癌治療学会誌 43 (2) 478 -478 2008年10月 [無し][無し]
  • 難治性精巣腫瘍に対するイリノテカンを用いた化学療法における半夏瀉心湯の有用性
    中村 晃和, 野々村 祝夫, 三神 一哉, 永原 啓, 高羽 夏樹, 河内 明宏, 水谷 陽一, 奥山 明彦, 三木 恒治 日本癌治療学会誌 43 (2) 720 -720 2008年10月 [無し][無し]
  • 内分泌抵抗性前立腺癌に対するハーブ療法の経験
    金沢 元洪, 浮村 理, 山田 剛司, 沖原 宏治, 高羽 夏樹, 水谷 陽一, 河内 明宏, 三木 恒治 日本癌治療学会誌 43 (2) 771 -771 2008年10月 [無し][無し]
  • 術前補助化学療法を行った進行性膀胱癌の検討
    三神 一哉, 水谷 陽一, 高羽 夏樹, 中村 晃和, 河内 明宏, 三木 恒治 日本癌治療学会誌 43 (2) 829 -829 2008年10月 [無し][無し]
  • 【EBMに基づく小児泌尿器科診療】 EBMに基づく夜尿症診療
    河内 明宏, 内藤 泰行, 三木 恒治 臨床泌尿器科 62 (10) 763 -768 2008年09月 [無し][無し]
     
    近年,国際的にも本邦においても,エビデンスに基づいた夜尿症の統一的な理解と治療法の確立を目指し,ガイドラインや治療戦略を作成する試みがなされている。今回,その中からInternational Children's Continence Society(ICCS)の用語の標準化に関する報告,Cochrane database,エビデンスに基づいた国際的治療戦略の報告および日本夜尿症学会の夜尿症診療ガイドラインについて概説する。(著者抄録)
  • 今後の前立腺がん検診の方向性を考える わが国における検診発見がん患者の動向について
    沖原 宏治, 北村 浩二, 三神 一哉, 浮村 理, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 16 (2) 28 -28 2008年09月 [無し][無し]
  • 尿失禁女性における排尿日誌、症状スコア、QOL-VASによる包括的評価の検討
    本城 久司, 浮村 理, 日野 こころ, 岡田 晃一, 河内 明宏, 北小路 博司, 中尾 昌宏, 三木 恒治 日本排尿機能学会誌 19 (1) 126 -126 2008年09月 [無し][無し]
  • 前立腺癌の再発予測におけるXIAPの有用性(Expression of X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Strong Predictor of Human Prostate Cancer Recurrence)
    本郷 文弥, 水谷 陽一, 河内 明宏, 三木 恒治 日本癌学会総会記事 67回 110 -110 2008年09月 [無し][無し]
  • 前立腺癌におけるdihydropyrimidine dehydrogenase(DPD)発現の重要性(Significance of the expression of dihydropyrimidine dehydrogenase (DPD) in prostate cancer)
    水谷 陽一, 李 永男, 安田 考志, 中村 晃和, 三神 一哉, 高羽 夏樹, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本癌学会総会記事 67回 325 -325 2008年09月 [無し][無し]
  • 経膀胱的体腔鏡下逆流防止術
    河内 明宏, 内藤 泰行, 邵 仁哲, 水谷 陽一, 三木 恒治 日本内視鏡外科学会雑誌 13 (7) 172 -172 2008年09月 [無し][無し]
  • 単腎の腎細胞癌に対して体腔鏡下腎部分切除術後に仮性腎動脈瘤を認めた1例
    本郷 文弥, 伊藤 吉三, 河内 明宏, 三木 恒治 日本内視鏡外科学会雑誌 13 (7) 372 -372 2008年09月 [無し][無し]
  • 腹腔鏡下腎部分切除術における新規医療用接着剤(LYDEX)の有用性
    内藤 泰行, 河内 明宏, 邵 仁哲, 沖原 宏治, 水谷 陽一, 中島 直喜, 須賀井 一, 玄 丞烋, 三木 恒治 日本内視鏡外科学会雑誌 13 (7) 372 -372 2008年09月 [無し][無し]
  • 糖尿病とED治療 基礎・臨床からのアプローチ
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 河内 明宏, 藤原 光文, 三木 恒治 日本性機能学会雑誌 23 (2) 175 -175 2008年08月 [無し][無し]
  • 2型糖尿病男性患者におけるテストステロン値の検討
    邵 仁哲, 兼光 紀幸, 納谷 佳男, 落合 厚, 内藤 泰行, 河内 明宏, 藤原 光文, 福井 道明, 中村 直登, 三木 恒治 日本性機能学会雑誌 23 (2) 234 -234 2008年08月 [無し][無し]
  • 膀胱全摘除術後に腟より腸管脱出を認めた1例
    福井 崇之, 白石 匠, 細田 光洋, 山田 剛司, 藤原 敦子, 谷口 英史, 金沢 元洪, 中村 晃和, 内藤 泰行, 邵 仁哲, 三神 一哉, 沖原 宏治, 浮村 理, 高羽 夏樹, 水谷 陽一, 河内 明宏, 三木 恒治 泌尿器科紀要 54 (7) 523 -524 2008年07月 [無し][無し]
  • 夜尿症児を持つ母親のQOL
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 19回 34 -34 2008年06月 [無し][無し]
  • アラーム療法
    河内 明宏, 内藤 泰行, 邵 仁哲, 三木 恒治 日本夜尿症学会学術集会プログラム・抄録集 19回 40 -40 2008年06月 [無し][無し]
  • アラーム療法およびデスモプレッシン(DDAVP)療法無効症例に対する第二選択療法の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 水谷 陽一, 三木 恒治 夜尿症研究 13 25 -28 2008年06月 [無し][無し]
     
    アラーム療法およびデスモプレッシン(DDAVP)療法無効例に対する第二選択療法について検討した。対象は、夜尿症患児156例(男性124例、女児32例・平均年齢9.90歳)で、第一選択にアラーム療法(76例)、DDAVP療法(80例)を3ヵ月以上行い、各々無効例には治療法を換えて継続した。3ヵ月後に夜尿回数が50%以下となった有効はアラーム療法39例(54%)、DDAVP療法42例(52%)、無効は各々37例(46%)、38例(48%)であった。アラーム療法無効例で引き続きDDAVP療法の同意を得たのは17例で、3ヵ月後の有効:9例(53%)、無効:8例(47%)であった。DDAVP療法無効例でアラーム療法の同意を得たのは27例で、3ヵ月後の有効:9例(33%)、無効:18例(67%)であった。第一選択のアラーム療法有効例で治療中止後に再発例は認めず、DDAVP療法有効例では17例(40%)に再発を認め、うち5例は引き続きアラーム療法を行い、3ヵ月後の有効:2例(40%)であった。以上、第一選択はアラーム療法が良いと考えられた。
  • 当科における体腔鏡下腎盂形成術
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 17 (1) 51 -51 2008年06月 [無し][無し]
  • 経膀胱的体腔鏡下逆流防止術
    河内 明宏, 内藤 泰行, 邵 仁哲, 三木 克治 日本小児泌尿器科学会雑誌 17 (1) 56 -56 2008年06月 [無し][無し]
  • アラーム療法およびデスモプレッシン(DDAVP)療法無効症例に対する第二選択療法の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 三木 恒治 日本小児泌尿器科学会雑誌 17 (1) 103 -103 2008年06月 [無し][無し]
  • Y. Mizutani, H. Nakanishi, T. Shiraishi, T. Nakamura, K. Mikami, N. Takaha, K. Okihara, O. Ukimura, A. Kawauchi, T. Miki JOURNAL OF CLINICAL ONCOLOGY 研究発表ペーパー・要旨(国際会議) 26 (15) 2008年05月 [無し][無し]
  • Takumi Shiraishi, Tatsushi Yoshida, Takashi Yasuda, Terukazu Nakamura, Kazuya Mikami, Natsuki Takaha, Mano Horinaka, Susumu Nakata, Ahmed E. Goda, Akiyoshi Nishikawa, Yoichi Mizutani, Akihiro Kawauchi, Toshiyuki Sakai, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 179 (4) 388 -389 2008年04月 [無し][無し]
  • Osamu Ukimura, Naoki Hirahara, Yasuhiro Yamada, Hisashi Honjo, Atsuko Fujihara, Daisuke Toiyama, So Ushijima, Koji Okihara, Yoichi Mizutani, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 179 (4) 520 -520 2008年04月 [無し][無し]
  • Akihiro Kawauchi, Yasuyuki Naitoh, Jintetsu Soh, Koji Okihara, Osamu Ukimura, Ybichi Mizutani, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 179 (4) 303 -304 2008年04月 [無し][無し]
  • Ybichi Mizutani, Hiroyuki Nakanishi, Takumi Shiraishi, Terukazu Nakamura, Kazuya Mikami, Natsuki Takaha, Koji Okihara, Osamu Ukimura, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 179 (4) 135 -135 2008年04月 [無し][無し]
  • Yoichi Mizutani, Yongnan Li, Takumi Shiraishi, Terukazu Nakamura, Kazuya Mikami, Natsuki Takaha, Koji Okihara, Osamu Ukimura, Akihiro Kawauchi, Tsuneharu Miki JOURNAL OF UROLOGY 研究発表ペーパー・要旨(国際会議) 179 (4) 107 -107 2008年04月 [無し][無し]
  • 【臨床睡眠学 睡眠障害の基礎と臨床】 臨床各論 睡眠時随伴症群(Parasomnias) そのほかの睡眠時随伴症 夜尿症
    河内 明宏, 内藤 泰行, 三木 恒治 日本臨床 66 (増刊2 臨床睡眠学) 362 -366 2008年04月 [無し][無し]
  • 腎・泌尿器科領域の超音波検診のoverview 京都府乙訓地域におけるPSA-densityを採用した前立腺癌検診
    北村 浩二, 田原 秀一, 三神 一哉, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 超音波医学 35 (Suppl.) S150 -S150 2008年04月 [無し][無し]
  • 腹腔鏡下腎部分切除後に腎仮性動脈瘤を認めた1例
    藤井 秀岳, 三神 一哉, 竹内 一郎, 中村 晃和, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 超音波医学 35 (2) 260 -260 2008年03月 [無し][無し]
  • 検診発見前立腺がんの内分泌治療成績
    北村 浩二, 田原 秀一, 三神 一哉, 沖原 宏治, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 16 (1) 107 -108 2008年03月 [無し][無し]
  • 小切開恥骨後式前立腺全摘除術におけるリアルタイム経直腸的超音波断層法の有用性
    沖原 宏治, 浮村 理, 牛嶋 壮, 高羽 夏樹, 水谷 陽一, 河内 明宏, 竹山 政美, 奥山 明彦, 三木 恒治 日本腎泌尿器疾患予防医学研究会誌 16 (1) 109 -110 2008年03月 [無し][無し]
  • 腹腔鏡下腎部分切除後に腎仮性動脈瘤を認めた1例
    藤井 秀岳, 三神 一哉, 竹内 一郎, 山田 剛司, 阿部 弘一, 中村 晃和, 河内 明宏, 三木 恒治 泌尿器科紀要 54 (2) 156 -156 2008年02月 [無し][無し]
  • 難易度の高い腹腔鏡下または開腹腎部分切除症例の手術法 腎腫瘍に対する体腔鏡下腎部分切除術
    河内 明宏, 邵 仁哲, 浮村 理, 水谷 陽一, 納谷 佳男, 伊藤 吉三, 藤戸 章, 宮下 浩明, 伊達 成基, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 127 -127 2008年02月 [無し][無し]
  • 先天異常に対する手術 ラパロか開腹か 経膀胱的体腔鏡下逆流防止術(Cohen法)の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 浮村 理, 水谷 陽一, 伊達 成基, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 129 -129 2008年02月 [無し][無し]
  • 当科における体腔鏡下腎盂形成術35例の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 浮村 理, 水谷 陽一, 藤戸 章, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 201 -201 2008年02月 [無し][無し]
  • 小切開恥骨後式前立腺全摘除術におけるリアルタイム経直腸的超音波断層法の有用性
    林 一誠, 沖原 宏治, 牛嶋 壮, 浮村 理, 高羽 夏樹, 水谷 陽一, 河内 明宏, 竹山 政美, 奥山 明彦, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 205 -205 2008年02月 [無し][無し]
  • IPSSの各症状に特異的なQOLを評価するVAS質問票による治療効果判定の検討
    牛嶋 壮, 浮村 理, 藤原 敦子, 問山 大輔, 沖原 宏治, 高羽 夏樹, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 241 -241 2008年02月 [無し][無し]
  • 腎癌におけるorotate phosphoribosyltransferase活性の上昇とその臨床的重要性
    水谷 陽一, 問山 大輔, 白石 匠, 中村 晃和, 三神 一哉, 高羽 夏樹, 牛嶋 壮, 内藤 泰行, 邵 仁哲, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 251 -251 2008年02月 [無し][無し]
  • 前立腺癌診断におけるAPTIMA PCA3 assayの有用性
    落合 厚, 沖原 宏治, 浮村 理, 納谷 佳男, 中村 晃和, 中西 弘之, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 275 -275 2008年02月 [無し][無し]
  • 再燃前立腺癌に対するタキサン系抗癌剤の初期治療成績
    高羽 夏樹, 沖原 宏治, 白石 匠, 牛嶋 壮, 浮村 理, 水谷 陽一, 河内 明宏, 南口 尚紀, 本郷 文弥, 伊藤 吉三, 鴨井 和実, 米田 公彦, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 296 -296 2008年02月 [無し][無し]
  • 前立腺癌の予後予測因子としてのX-linked inhibitor of apoptosis protein(XIAP)の有効性
    本郷 文弥, セリグソン・デビッド, グッドグリック・リー, ボナビダ・ベンジャミン, 伊藤 吉三, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 378 -378 2008年02月 [無し][無し]
  • DU145前立腺癌細胞に対するLOX阻害剤であるnordihydroguaiaretic acid(NDGA)によるTRAILを介したアポトーシスの増強
    白石 匠, 吉田 達士, 安田 考志, 中村 晃和, 三神 一哉, 高羽 夏樹, 中田 晋, 堀中 真野, 水谷 陽一, 河内 明宏, 酒井 敏行, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 382 -382 2008年02月 [無し][無し]
  • 前立腺癌の診断におけるelastographyの有用性の検討
    金沢 元洪, 鴨井 和実, 牛嶋 壮, 落合 厚, 沖原 宏治, 浮村 理, 高羽 夏樹, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 390 -390 2008年02月 [無し][無し]
  • 内分泌単独療法を施行した前立腺癌患者の臨床検討
    竹内 一郎, 沖原 宏治, 増田 健人, 南口 尚紀, 大嶺 卓司, 伊藤 吉三, 浮村 理, 高羽 夏樹, 水谷 陽一, 河内 明宏, 北村 浩二, 藤戸 章, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 399 -399 2008年02月 [無し][無し]
  • 膀胱癌におけるorotate phosphoribosyltransferase活性の臨床的重要性
    阿部 弘一, 水谷 陽一, 問山 大輔, 安田 考志, 矢野 公大, 白石 匠, 中村 晃和, 三神 一哉, 高羽 夏樹, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 431 -431 2008年02月 [無し][無し]
  • 術前尿細胞診がClass 3以上を示す膀胱癌症例における上部尿路尿細胞診の意義
    三神 一哉, 水谷 陽一, 中村 晃和, 白石 匠, 野本 剛史, 高羽 夏樹, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 436 -436 2008年02月 [無し][無し]
  • 難治性精巣腫瘍における肺、肝転移巣に対するラジオ波焼灼術(RFA)の経験
    野本 剛史, 中村 晃和, 河内 明宏, 三神 一哉, 白石 匠, 高羽 夏樹, 水谷 陽一, 山上 卓士, 西村 恒彦 日本泌尿器科学会雑誌 99 (2) 458 -458 2008年02月 [無し][無し]
  • アラーム療法およびデスモプレッシン(DDAVP)療法無効症例に対する第二選択療法の検討
    稲葉 光彦, 内藤 泰行, 邵 仁哲, 沖原 宏治, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 466 -466 2008年02月 [無し][無し]
  • 腎癌症例における血清X-linked inhibiter apoptosis protein(XIAP)値の臨床的意義
    問山 大輔, 水谷 陽一, 矢野 公大, 白石 匠, 中村 晃和, 三神 一哉, 高羽 夏樹, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 486 -486 2008年02月 [無し][無し]
  • 腎腫瘍に対する経皮的ラジオ波焼灼術の経験
    平岡 健児, 河内 明宏, 中村 晃和, 白石 匠, 邵 仁哲, 内藤 泰行, 三神 一哉, 浮村 理, 水谷 陽一, 山上 卓士, 西村 恒彦, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 490 -490 2008年02月 [無し][無し]
  • 夜間頻尿2回以上を伴った前立腺肥大症症例に対するナフトピジルと塩酸タムスロシンとの治療効果の前向き比較試験
    石田 博万, 浮村 理, 牛嶋 壮, 沖原 宏治, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 499 -499 2008年02月 [無し][無し]
  • 中尾 昌宏, 有働 幸紘, 岡田 晃一, 本城 久司, 杉本 佳史, 日野 こころ, 北小路 博司, 浮村 理, 水谷 陽一, 河内 明宏, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 511 -511 2008年02月 [無し][無し]
  • 2型糖尿病患者(男性)におけるテストステロン値と動脈硬化との関連性に関する検討
    兼光 紀幸, 邵 仁哲, 納谷 佳男, 落合 厚, 内藤 泰行, 米田 公彦, 河内 明宏, 藤原 光文, 福井 道明, 吉川 敏一, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 515 -515 2008年02月 [無し][無し]
  • 高グルコース刺激によるヒト陰茎海綿体平滑筋細胞内でのIGFBP-3発現量の変化に関する検討
    邵 仁哲, 兼光 紀幸, 内藤 泰行, 落合 厚, 納谷 佳男, 米田 公彦, 小森 和彦, 辻村 晃, 河内 明宏, 奥山 明彦, 三木 恒治 日本泌尿器科学会雑誌 99 (2) 523 -523 2008年02月 [無し][無し]
  • 京都府乙訓地域におけるPSA-densityを採用した前立腺がん検診の現状
    北村 浩二, 田原 秀一, 三神 一哉, 沖原 宏治, 浮村 理, 河内 明宏, 三木 恒治 日本がん検診・診断学会誌 15 (2) 132 -134 2008年01月 [無し][無し]
     
    1995〜2004年までの二次検診受診者894名を対象に、二次検診におけるPSA-density(PSAD)の有用性について検討した。その結果、二次検診にPSADを導入することで289名(32%)の生検を回避することができた。だが、そのうち147名(51%)がその後も検診を繰り返し受診し、うち80名に生検が施行され、23名で前立腺がんが発見された。更に次年度以降も毎年検診を受診して発見された前立腺がん症例はすべて臨床病期Bの早期がんであった。以上、これらのことからも、効率的な前立腺生検対象者の絞込みにはPSADは有用であり、次年度も継続して検診を受診するよう勧めることが重要であると考えられた。
  • 高血糖状態におけるヒト陰茎海綿体平滑筋細胞を用いたIGF-Iの細胞増殖効果の検討
    邵 仁哲, 兼光 紀幸, 石田 裕彦, 内藤 泰行, 落合 厚, 納谷 佳男, 米田 公彦, 河内 明宏, 三木 恒治, 小森 和彦, 辻村 晃, 奥山 明彦 日本性機能学会雑誌 22 (3) 331 -332 2007年12月 [無し][無し]
  • Transrectal elastographyが診断に有用であった前立腺癌の1例
    沖原 宏治, 鴨井 和実, 落合 厚, 牛嶋 壮, 浮村 理, 河内 明宏, 三木 恒治 超音波医学 34 (6) 625 -625 2007年11月 [無し][無し]
  • 夜尿症に関する最近の知見
    河内 明宏, 内藤 泰行, 三木 恒治 日本小児腎臓病学会雑誌 20 (2) 159 -163 2007年11月 [無し][無し]
     
    近年、国際的にも本邦においても、エビデンスに基づいた夜尿症の統一的な理解と治療法の確立を目指し、ガイドラインや治療戦略を作成する試みがなされている。今回、その中から、International Children's Continence Society(ICCS)の用語の標準化に関する報告、エビデンスに基づいた国際的治療戦略の報告および日本夜尿症学会の夜尿症診療ガイドラインについて概説する。(著者抄録)
  • 前立腺にComedo necrosisを合併した膀胱尿路上皮癌の1例
    朴 英寿, 沖原 宏治, 水谷 陽一, 河内 明宏, 三木 恒治, 藤戸 章 泌尿器外科 20 (11) 1463 -1465 2007年11月 [無し][無し]
     
    症例77歳男性。無症候性肉眼的血尿を主訴に受診。膀胱鏡検査にて右側壁に乳頭状広基性腫瘍を認めた。膀胱癌(T3bN0M0)の診断にて抗癌剤動脈内注入療法および全身化学療法施行後に右腎尿管膀胱前立腺全摘除術および左尿管皮膚瘻造設術を施行した。摘出前立腺組織にComedo necrosisを認め、免疫染色を施行したところPSAおよびPAP染色ともに陰性であった。膀胱移行上皮癌が前立腺導管に浸潤しComedo necrosisを形成したと考えられた。(著者抄録)
  • 当科における体腔鏡下腎盂形成術の検討
    内藤 泰行, 河内 明宏, 邵 仁哲, 浮村 理, 水谷 陽一, 米田 公彦, 南口 尚紀, 北村 浩二, 伊藤 吉三, 三木 恒治 Japanese Journal of Endourology and ESWL 20 (3) 134 -134 2007年11月 [無し][無し]
  • 体腔鏡下逆流防止術
    河内 明宏, 内藤 泰行, 邵 仁哲, 水谷 陽一, 三木 恒治 Japanese Journal of Endourology and ESWL 20 (3) 150 -150 2007年11月 [無し][無し]
  • 単腎の腎細胞癌に体腔鏡下腎部分切除術後に腎動静脈瘻を伴う仮性腎動脈瘤を認めた1例
    本郷 文弥, 伊藤 吉三, 廣田 英二, 関 英夫, 藤田 正人, 大江