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遠山 育夫

所属部署名神経難病研究センター
職名教授
 
 
更新日: 17/08/29 06:53

研究者基本情報

氏名

    遠山 育夫

基本情報

    ハンドル:  handle0018827
    科研費研究者番号:  20207533

所属(マスタ)

  • 神経難病研究センター 教授

学歴

  • - 1988年京都大学 医学研究科 内科学
  • - 1981年京都大学 医学部 医学部

学位

  • 医学博士(京都大学)

所属学協会

    国際神経科学会(IBRO) , 日本組織細胞化学会 , 日本神経化学会 , 日本認知症学会 , 米国神経科学会 , 日本解剖学会 , 日本神経学会 , ニューヨーク科学アカデミー , 日本神経科学学会 , 日本脳科学会

委員歴

  • 2017年01月- 現在日本組織細胞化学会 監事
  • 2016年06月- 現在日本神経病理学会 評議員
  • 2003年- 現在日本脳科学会 理事
  • 2000年- 現在日本認知症学会 理事
  • 1998年- 現在日本解剖学会 評議員
  • 1995年- 現在日本組織細胞化学会 評議員

経歴

  • 2010年-  滋賀医科大学分子神経科学研究センター長
  • 1995年- 1999年 滋賀医科大学 助教授
  • 1999年- 滋賀医科大学教授
  • 1988年- 1995年 滋賀医科大学 助手

研究活動情報

研究分野

  • 内科系臨床医学 / 神経内科学
  • 神経科学 / 神経科学一般
  • 神経科学 / 神経解剖学・神経病理学

研究キーワード

    神経内科学 , 神経科学 , 神経解剖学・神経病理学

論文

  • Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.
    Kitamura Y, Inden M, Kimoto Y, Takata K, Yanagisawa D, Hijioka M, Ashihara E, Tooyama I, Shimohama S, Ariga H
    Journal of Alzheimer's disease : JAD 55(1) 67-72 2016年11月 [査読有り]
  • Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration.
    Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I
    Neurobiology of aging 47 168-179 2016年11月 [査読有り]
  • Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice.
    Ibrahim NF, Yanagisawa D, Durani LW, Hamezah HS, Damanhuri HA, Wan Ngah WZ, Tsuji M, Kiuchi Y, Ono K, Tooyama I
    Journal of Alzheimer's disease : JAD 55(2) 597-612 2016年11月 [査読有り]
  • Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease.
    Yanagisawa D, Oda K, Inden M, Morikawa S, Inubushi T, Taniguchi T, Hijioka M, Kitamura Y, Tooyama I
    Journal of neuroscience research 2016年10月 [査読有り]
  • Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).
    Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S
    Ageing research reviews 30 85-94 2016年09月 [査読有り]
  • S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer's disease.
    Sonoda Y, Tooyama I, Mukai H, Maeda K, Akiyama H, Kawamata T
    Neuropathology : official journal of the Japanese Society of Neuropathology 36(4) 325-332 2016年08月 [査読有り]
  • Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis.
    Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I
    Neuroscience 328 92-106 2016年07月 [査読有り]
  • Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia.
    Ogawa T, Irikawa N, Yanagisawa D, Shiino A, Tooyama I, Shimizu T
    Auris, nasus, larynx 2016年07月 [査読有り]
  • Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body.
    Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M
    Scientific reports 6 24868 2016年04月 [査読有り]
  • α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior.
    Inden M, Takata K, Yanagisawa D, Ashihara E, Tooyama I, Shimohama S, Kitamura Y
    Neurochemistry international 94 74-81 2016年03月 [査読有り]
  • Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer’s disease patients
    Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I
    Neuroscience Letters 591 19-24 2015年03月 [査読有り]
  • Upregulation of mitochondrial ferritin by proinflammatory cytokines: implications for a role in Alzheimer's disease.
    Yang H, Guan H, Yang M, Liu Z, Takeuchi S, Yanagisawa D, Vincent SR, Zhao S, Tooyama I
    Journal of Alzheimer's disease : JAD 45(3) 797-811 2015年01月 [査読有り]
  • Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice.
    Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
    Neurobiology of aging 36(1) 201-210 2015年01月 [査読有り]
  • CG-containing oligonucleotides and transcription factor-binding motifs are enriched in human pericentric regions.
    Wada Y, Iwasaki Y, Abe T, Wada K, Tooyama I, Ikemura T
    Genes & genetic systems 90(1) 43-53 2015年 [査読有り]
  • Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds.
    Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
    Australian Journal of Chemistry 68 224-229 2015年
  • Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease.
    McClure R, Yanagisawa D, Stec D, Abdollahian D, Koktysh D, Xhillari D, Jaeger R, Stanwood G, Chekmenev E, Tooyama I, Gore JC, Pham W
    Journal of Alzheimer's disease : JAD 44(1) 283-295 2015年 [査読有り]
  • A Mutation of COX6A1 Causes a Recessive Axonal or Mixed Form of Charcot-Marie-Tooth Disease.
    Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.
    Am J Hum Genet 95(3) 294-300 2014年09月 [査読有り]
  • New Proteomic Insights on the Role of NPR-A in Regulating Self-Renewal of Embryonic Stem Cells.
    Magdeldin S, Yamamoto T, Tooyama I, Abdelalim EM
    Stem Cell Reviews and Reports 10(4) 561-572 2014年08月 [査読有り]
  • The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
    Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M.
    Nat Commun 5 3917 2014年06月 [査読有り]
  • Immunohistochemical Localization of an Isoform of TRK-Fused Gene-Like Protein in the Rat Retina
    Masuda C, Takeuchi S, Bisem NJ, R Vincent S, Tooyama I.
    Acta Histochem Cytochem.  47(2) 75-83 2014年05月 [査読有り]
  • Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.
    Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Tooyama I
    J Alzheimers Dis 39(3) 617-631 2014年
  • Knockdown of p53 suppresses Nanog expression in embryonic stem cells.
    Abdelalim EM, Tooyama I
    Biochem Biophys Res Commun 443(2) 652-657 2014年
  • Analysis of new biomarkers for cholangiocarcinoma.
    Miwa M, You G, Tanaka H, Taniguchi S, Fujii T, Kamemura K, Suzaki M, Isono T, Tooyama I, Tanaka M, Srivatanakul P, Viwatthanasittiphong C, Sangrajrang S, Khuhaprema T
    J Hepatobiliary Pancreat Sci.  21(6) 397-398 2014年
  • Generation of a monoclonal antibody specifically recognizing with neuron-specific TATA-box binding protein-associated factor 1 (TAF-1).
    Makino S, Masuda C, Ando S, Tamiya G, Tooyama I
    Antibodies 2 1-8 2013年
  • Expression of NPR-B in neurons of the dorsal root ganglia of the rat. Peptides.
    Abdelalim EM, Bellier JP, Tooyama I
    Peptides 43 56-61 2013年
  • Immunoreactivity for choline acetyltransferase of peripheral-type (pChAT) in the trigeminal ganglion neurons of the non-human primate Macaca fascicularis.
    Koga T, Bellier JP, Kimura H, Tooyama I
    Acta Histochem Cytoc 46 59-64 2013年
  • Kainic acid induces expression of caveolin-1 in activated microglia in rat brain.
    Takeuchi S, Matsuda W, Tooyama I, Yasuhara O
    Folia Histochem Cytobiol 51 25-30 2013年
  • β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway.
    Kameshima N, Yanagisawa D, Tooyama I
    Neurosci Res 76 169-172 2013年
  • Visualizing Hepatic Copper Release in Long-Evans Cinnamon Rats Using Single-Photon Emission Computed Tomography.
    Yezdimer EM, Umemoto T, Yamada H, Makino S, Tooyama I
    Appl Biochem Biotechnol 170 1138-1150 2013年
  • Response to fish specific reproductive hormones and endocrine disrupting chemicals of a Sertoli cell line expressing endogenous receptors from an endemic cyprinid Gnathopogon caerulescens.
    Higaki S, Koyama Y, Shimada M, Ono Y, Tooyama I, Fujioka Y, Sakai N, Ikeuchi T, Takada T
    Gen Comp Endocr 191 65-73 2013年
  • Mitochondrial ferritin in neurodegenerative diseases.
    Yang H, Yang M, Guan H, Liu Z, Zhao S, Takeuchi S, Yanagisawa D, Tooyama I
    Neurosci Res 77(1-2) 1-7 2013年
  • Distinct localization of peripheral and central types of choline acetyltransferase in the rat cochlea.
    Kitanishi T, Aimi Y, Kitano H, Suzuki M, Kimura H, Saito A, Shimizu T, Tooyama I
    Acta Histochem Cytochem 46(5) 142-145 2013年
  • Human neural stem cells overexpressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction.
    Park D, Lee HJ, Joo SS, Lim I, Matsuo A, Tooyama I, Kim YB, Kim SU
    Exp Neurol 234(2) 521-526 2012年
  • Expression and localization of TRK-fused gene products in the rat brain and retina.
    Maebayashi H, Takeuchi S, Masuda C, Makino S, Fukui K, Kimura H, Tooyama I
    Acta Histochem Cytochem 45 15-23 2012年
  • Immunohistochemcial mapping of TRK-fused gene products in the rat brainstem.
    Takeuchi S, Masuda C, maebayashi H, Tooyama I
    Acta Histochem Cytochem 45 57-64 2012年
  • Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease
    Kameshima N, Nanjou T, Fukuhara T, Yanagisawa D, Tooyama I
    Neurosci Lett 513 166-169 2012年
  • Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals.
    Park D, Joo SS, Kim TK, Lee SH, Kang H, Lee HJ, Lim I, Matsuo A, Tooyama I, Kim YB, Kim SU
    Cell Transplantaion 21(1) 365-371 2012年
  • Transition metal abnormalities in progressive dementia.
    Akatsu H, Hori A, Yamamotto T, Hashizume Y, Yoshida M, Mimuro M, Tooyama I, Yezdimer EM
    Biometals 25(2) 337-350 2012年
  • The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells.
    Abdelalim EM, Tooyama I
    Biochem Biophys Res Commun 420 605-610 2012年
  • Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model.
    Inden M, Abe M, Minamino H, Takata K, Yoshimoto K, Tooyama I, Kitamura Y
    J Pharmacol Sci 119 10-19 2012年
  • NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels
    Abdelalim EM, Tooyama I
    Stem Cells and Development 21(8) 1264-1271 2012年
  • Age-related modulation of γ-secretase activity in non-human primate brains.
    Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I.
    J Neurochem 123(1) 21-28 2012年
  • In vivo detection of copper ions by magnetic resonance imaging using a prion-based contrast agent.
    Makino S, Umemoto T, Yamada H, Yezdimer EM, Tooyama I
    Appl Biochem Biotechnol 168 504-518 2012年
  • Mapping of FGF1 in the medulla oblongata of Macaca fascicularis.
    Bisem NJ, Takeuchi S, Imamura T, Abdelalim EM, Tooyama I
    Acta Histochem Cytochem 45 325-334 2012年
  • Curcuminoid Binds to Amyloid-β1-42 Oligomer and Fibril.
    Yanagisawa D, Taguchi H, Yamamoto A, Shirai N, Hirao K, Tooyama I
    J Alzheimer 24 33-42 2011年
  • NPR-A regulates self-renewal and pluripotency of embryonic stem cells.
    Abdelalim EM, Tooyama I
    Cell Death Dis 10(2) e127 2011年
  • In vivo detection of amyloid β deposition using (19)F magnetic resonance imaging with a (19)F-containing curcumin derivative in a mouse model of Alzheimer's disease.
    Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I.
    Neuroscience. 2011 Jun 16;184:120-7. Epub 2011 Apr 12. 184 120-1277 2011年
  • Expression profiles of cytokines in the brains from Alzheimer’s disease (AD) patients, compared to the brains from normal control subjects and non-demented patients with increasing AD pathology.
    Morimoto K, Horio J, Sato H, Sue L, Beach T, Arita S, Tooyama I, Konishi Y
    J Alzheimer 25(1) 59-76 2011年
  • Expression and localization of mitochondrial ferritin mRNA in Alzheimer’s disease cerebral cortex.
    Wang L, Yang H, Zhao S, Sato H, Konishi Y, Beach TG, Abdelalim EM, Bisem NJ, Tooyama I
    PLOS ONE 6(7) e22325 2011年
  • Indentification and localization of a neuron-specfic isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia
    Sako W, Morigaki R, Kaji R, Tooyama I, Okita S, Kitazato K, Nagahiro S, Graybiel AM, Goto S
    NEUROSCIENCE 189 100-107 2011年
  • Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis
    Abdelalim EM, Tooyama I
    Brain Structure & Function 216(4) 387-402 2011年
  • NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina.
    Abdelalim EM, Tooyama I
    Peptides 31 180-183 2010年
  • Induction of protective immunity by vaccination with wild-type apo SOD1 in the mutant SOD1 transgenic mice
    Takeuchi S, Fujiwara N, Ido A, Ono M, Takeuchi Y, Tateno M, Suzuki K, Takahashi R, Tooyama I, Taniguchi N, Julien JP, Urushitani M
    J Neuropathol Exp Neurol 69 1044-1056 2010年
  • Depositon of lactoferrin in fibrillar-type senile plaques in the brain of transgenic mouse models of Alzheimer’s disease.
    Wang L, Sato H, Zhao S, Tooyama I
    NEUROSCIENCE LETTERS 481 164-167 2010年
  • Realationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer's disease.
    Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada KN, Yamamoto A, Tooyama I
    BIOMATERIALS 31 4179-4185 2010年
  • Infiltration of T lymphocytes and expression of icam-1 in the hippocampus of patients with hippocampal sclerosis.
    Nakahara H, Konishi Y, Beach TG, Yamada N, Makino S, Tooyama I
    Acta Histochem Cytochem 43(6) 157-162 2010年
  • Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging.
    Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I
    NEUROSCIENCE RESEARCH 63 76-81 2009年
  • Axotomy Alters Alternative Splicing of Choline Acetyltransferase in the Rat Dorsal Motor Nucleus of the Vagus Nerve.
    Saito A, Sato T, Okano H, Toyoda K, Bamba H, Kimura S, Bellier JP, Matsuo A, Kimura H, Hisa Y, Tooyama I
    Journal of Comparative Neurology 513(2) 237-248 2009年
  • Oxidative stress induction of DJ-1 protein in reactive astrocytes scavengers free radicals and reduces cell injury
    Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata K, Shibaike T, Yamamoto A, Tniguchi T, Ysui H, Tairs T, Morikawa S, Inubushi T, Tooyama I, Ariga H
    Oxid Med Cell Longev 2(1) 36-42 2009年
  • BNP signaling is crucial for embryonic stem cell proliferation
    Abdelalim EM, Tooyama I
    PLoS ONE 4(4) e5341 2009年
  • Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons
    Sato T, Takeuchi S, Saito A, Ding W, Matsuura H, Bamba H, Hisa Y, Tooyama I, Urushitani M
    Neuroscience 164(4) 1565-1578 2009年
  • The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues.
    Oda K, Makino S, Masuda C, Yoshiki T, Kitamura Y, Takada T, Yanagisawa D, Taniguchi T, Tooyama I
    J Histochem Cytochem  57 1121-1126 2009年
  • Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease
    An L, Sato H, Konishi Y, Walker DG, Beach TG, Rogers J, Tooyama I
    Neurosci Lett 452 277-280 2009年
  • The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS
    Urushitani M, Ezzi SA, Matsuo A, Tooyama I, Julien JP
    FASEB J 22(7) 2476-2487 2008年
  • DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats
    Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama I, Taira T, Iguchi-Ariga MM S, Akaike A, Ariga H
    J Cereb Blood Flow Metab 28(3) 563-578 2008年
  • Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina
    Abdelalim E M, Masuda C, Tooyama I
    Peptides 29(4) 622-628 2008年
  • Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons.
    Abdelalim EM, Masuda C, Bellier JP, Saito A, Yamamoto S, Mori N, Tooyama I
    Neuroscience 155 192-202 2008年
  • The MR tracking of ATDC5 cells using fluorinated poly-L-Lysine-CF3.
    Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I
    Biomaterials 28(3) 434-440 2007年
  • The production of antibodies that distinguish rat choline acetyltransferase from its splice variant product of a peripheral type.
    Kimura S, Bellier J-P, Matsuo A, Tooyama I, Kimura H
    Neurochem Int 50(1) 251-255 2007年
  • Microglial transplantation increases amyloid-? clearance in Alzheimer model rats.
    Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuichiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I
    FEBS Lett 581(3) 475-478 2007年
  • Reduced Neuron-Specific Expression of the TAF1 Gene Is Associated with X-Linked Dystonia-Parkinsonism.
    Makino S, Kaji R, Ando S, Tomizawa M, Yasuno K, Goto S, Matsumoto S, Tabuena MD, Maranon E, Dantes M, Lee LV, Ogasawara K, Tooyama I, Akatsu H, Nishimura M, Tamiya G
    Am J Hum Genet 80(3) 393-406 2007年
  • Immunohistochemical mapping of natriuretic peptide receptor-A in the brainstem of Macaca fascicularis
    Abdelalim EM., Osman AH., Takada T., Torii R., Tooyama I.
    Neuroscience 145 1087-1096 2007年
  • Low Expression of FGF1 (Fibroblast Growth Factor-1) in Rat Parasympathetic Preganglionic Neurons
    Saito A, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Tooyama I
    Histology and Histopathology 22 1327-1335 2007年
  • Fluorine-19 fast recovery fast spin echo imaging for mapping 5-Fluorouracil.
    Morikawa S, Inubushi T, Morita M, Murakami K, Masuda C, Maki J, Tooyama I
    Magn Reson Med Sci 6(4) 235-240 2007年
  • In vitro expression of Natriureic peptides in cardiomyocytes differentiated from monkey embryonic stem cells
    Abdelalim E, Takada T, Toyoda F, Omatsu-Kanbe M, Matsuura H, Tooyama I, Torii R
    Biochem. Biophys. Res. Commun 340 689-695 2006年
  • Comparison of FGF1 (aFGF) Expression between the Dorsal Motor Nucleus of Vagus and the Hypoglossal Nucleus of Rat
    Toyoda K, Okano H, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Tooyama I
    Acta Histochem Cytochem 39 1-7 2006年
  • Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding ?-amyloid deposits in the rat brain.
    Song Y, Morikawa S, Morita M, Inubushi T, Takada T, Torii R, Kitamura Y, Taniguchi T, Tooyama I
    Histol Histopathol  21(7) 705-711 2006年
  • Molecular Cloning of BNP from Heart and Its Immunohistochemical Localization in the Hypothalamus of Monkey.
    Abdelalim EM, Takada T, Torii R, Tooyama I.
    Peptides 27(7) 1886-1893 2006年
  • Localization of fibroblast growth factor-1 (FGF1) in cholinergic neurons innervating the rat larynx.
    Okano H, Toyoda K, Bamba H, Hisa Y, Oomura Y, Imamura T, Furukawa S, Kimura H, Tooyama I
    J Histochem Cytochem 54(9) 1061-1067 2006年
  • MR tracking of glial cells using poly-L-Lysine-CF3.
    Masuda C, Maki J, Morikawa S, Morita M, Inubushi T, Matsusue Y, Yamagata S, Taguchi H, Doi Y, Shirai N, Hirano K, Tooyama I
    Neurosci Res 56(2) 224-228 2006年
  • Variations in the Brain-Derived Neurotrophic Factor (BDNF) Gene have no significant association with autopsy-confirmed Alzheimer’s disease or Dementia with Lewy bodies in Japanese subjects.
    Akatsu H, Yamagata H, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K, Okada H
    Dementia Geriatric Cogn Dis  22(3) 216-222 2006年
  • Rat choline acetyltransferase of the peripheral type differs from that of the common type in translocation.
    Matsuo A, Bellier J-P, Hisano T, Aimi Y, Yasuhara O, Tooyama I, Saito N, Kimura H
    Neurochem. Int. 46(5) 423-433 2005年
  • Mouse brain IgG-like immunoreactivity: strain-specific occurrence in microglia and biochemical identification of IgG
    Hazama G, Yasuhara O, Morita H, Aimi Y, Tooyama I, Kimura H
    J Comp Neurol 492 234-249 2005年
  • Functional anatomy of the basal ganglia in X-linked recessive dystonia-parkinsonism
    Goto S, Lee LV, Munoz EL, Tooyama I, Tamiya G, Makino S, Ando S, Dantes MB, Yamada K, Matsumoto S, Shimazu H, Kuratsu JI, Hirano A, Kaji R
    Ann Neurol 58 7-17 2005年
  • Immunohistochemical study of TAFII250 in the rat laryngeal nervous system
    Okano H, Bamba H, Hisa Y, Makino S, Ando S, Tammiya G, Goto S, Kaji R, Tooyama I
    Histol Histopathol 20(4) 1029-1035 2005年
  • Innervation of rat iris by trigeminal and ciliary neurons expressing pChAT, a novel splice variant of choline acetyltranferase
    Yasuhara O, Aimi Y, Shibano A, Matsuo A, Bellier JP, Park M, Tooyama I, Kimura H
    J Comp Neurol 472(2) 232-245 2004年
  • Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.
    Casini A, Pinna I, Tooyama I, Kimura H, Chiara Di G, Renda TG
    Eur. J. Histochem. 48 135-140 2004年
  • Ameliorative effects of acetyl-L-carnitine and acidic fibroblast growth factor fragment analog on brain lipid hydroperoxide level, passive avoidance learning and/or immunoreactivity for choline acetyltransferse in the medial septum in senesence-acceler・・・
    Sasaki K, Ishibashi M, Yasui F, Matsugo S, Tooyama I, Kimura H, Oomura Y
    International Congress Series 1260 123-128 2004年
    Ameliorative effects of acetyl-L-carnitine and acidic fibroblast growth factor fragment analog on brain lipid hydroperoxide level, passive avoidance learning and/or immunoreactivity for choline acetyltransferse in the medial septum in senesence-accelerated mice.
  • Coexpression pattern of neuronal nitric oxide synthase and two variants of choline acetyltransferase in myenteric neurons of porcine ileum.
    Brehmer A, Schr?dl F, Neuhuber W, Tooyama I, Kimura H
    J. Chem. Neuroanat. 27 33-41 2004年
  • Effective magnetic labelling of transplanted cells with HVJ-E for magnetic resonance imaging.
    Toyoda K, Tooyama I, Kato M, Sato H, Morikawa S, Hisa Y , Inubushi T
    NeuroReport 15 589-593 2004年
  • Deposition of alpha2-macrogobulin in fibrillar type of senile plaques in the brain of PS/APP-transgenic mice
    Kondo T, Tooyama I
    Acta Histochem Cytochem 36 215-220 2003年
  • Detection of viral DNA in the endolymphatic sac in Meniere's disease by in situ hybridization
    Yazawa Y, Suzuki M, Hanamitsu M, Kimura H, Tooyama I
    ORL J Otorhinolaryngol Relat Spec. 65 162-168 2003年
  • Demonstration of cholinergic ganglion cells in rat retina; expression of an alternative splice variant of choline acetyltransfer
    Yasuhara O, Tooyama I, Aimi Y, Bellier JP, Hisano T, Matsuo A, Park M, Kimura H
    J Neurosci 23 2872-2881 2003年
  • Demonstration of fibroblast growth factor receptor-1 in rat adrenal gland as revealed by reverse transcription-polymerase chain reaction and immunohistochemistry.
    Iwami M, Tooyama I, Kinoshita A, Matsuo A, Oomura Y, Sasaki K, Kimura H
    Acta Histochem. Cytochem. 36 353-359 2003年
  • Binding avidity of immunoglobulin G for acetylcholine.
    Tsuji S, Tooyama I, Kato T, Peltre G, Kimura H
    Biomed. Res. 24 217-221 2003年
  • Expression of a splice variant of choline acetyltransferase in magnocellular neurons of the tuberomammillary nucleus of rat.
    Kanayama H, Yasuhara O, Matsuo A, Tooyama I, Aimi Y, Bellier J-P, Nagy JI, Fukui K, Kimura H
    Neuroscience(118) 243-251 2003年
  • Molecular mechanisms in Alzheimer's disease
    Kimura H, Aimi Y, Minnash P, Yasuhara O, Bellier JP, Tooyama I
    Res Legal Medicine 27 161-174 2002年
  • Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy.
    Tooyama I, Bellier JP, Park M, Minnasch P, Uemura S, Hisano T, Iwami M, Aimi Y, Yasuhara O, Kimura H
    Epilepsia 43 Suppl(9) 39-43 2002年
  • Immunoreactive neurons in the brain of two mouse strains after incubation with an antiserum recognizing Asp-Val-Val-Gly.NH2 (DVVG), the C-terminal fragment of (D-Ala2)-deltorphin I.
    D'Este L, Casini A, Puglisi-Allegra S, Cabib S, Tooyama I, Kimura H, Renda TG
    J. Chem. Neuroanat. 24 189-198 2002年
  • 2-Buten-4-olide, an endogenous feeding suppressant, improves spatial performance through brain acidic fibroblast growth factor
    XL Li, S Aou, AJ Li, I Tooyama, Y Oomura
    Brain Res Bull 56 531-536 2001年
  • [D-Ala2]deltorphin I-like immunoreactivity in fetal lung: d and m opiate receptors mediate opposite developmental effects.
    Sunday ME, Haley KJ, Emanuel RL, Torday JS, Asokananthan N, Sikorski KA, Tooyama I, Kimura H, Renda T, Erspamer V
    Respiratory Cell and Molecular Biology 25 447-456 2001年
  • Fetal Alveolar Epithelial Cells Contain [D-Ala(2)]-Deltorphin I-like Immunoreactivity. Delta- and mu-opiate receptors mediate opposite effects in developing lung.
    Sunday ME, Haley KJ, Emanuel RL, Torday JS, Asokananthan N, Sikorski KA, Tooyama I, Kimura H, Renda T, Erspamer V.
    American Journal of Respiratory Cell and Molecular Biology 25 447-456 2001年
  • Endolymphatic hydrops by Administration of vasopressin in the rat.
    Kitano H, Takeda T, Takeda S, Suzuki M, Kitanishi T, Kitajima K, Kimura H, Tooyama I
    Acta Histochem. Cytochem. 34 229-233 2001年
  • Demonstration of acidic fibroblast growth factor (FGF-1) in rat adrenal gland.
    Matsuoka Y, Aimi Y, Kimura H, Taniguchi T, Oomura Y, Sasaki K, Tooyama I
    Acta histochem cytochem 34 129-134 2001年
  • Production and immunohitochemical application of antiserum againProduction of monoclonal antibody to deltorphin-I and its immuno
    Yu S, Zhao T, Fan M, Tooyama I, Kimura H, Renda TG
    Peptides 21 1657-1662 2000年
  • Production of monoclonal antibody to deltorphin-I and its immunocytochemical application to adult rat brain and cultured rat brain neurons.
    Yu S, Zhao T, Fan M, Tooyama I, Kimura H, Renda TG
    Peptides 21 1657-1662 2000年
  • Production and immunohitochemical application of antiserum against Tyr-D-Ala-Phe, a N-terminal tripeptide common to dermorphin/deltorphin family.
    Tooyama I, Abe H, Renda TG, Kimura H
    Peptides 21 1649-1655 2000年
  • A protein encoded by an alternative splice variant of choline acetyltransferase mRNA is localized preferentially in peripheral nerve cells and fibers
    Tooyama I, Kimura H
    J. Chem. Neuroanat 17 217-226 2000年
  • Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy
    Nakagawa E, Aimi Y, Yasuhara O, Tooyama I, Shimada M, McGeer PL, Kimura H
    Epilepsia 41 10-18 2000年
  • Microglial reaction and neuronal death in the hippocampus of rat models of epilepsy
    Tooyama I, Nishimura T, Nakagawa E, Morita H, Uemura S, Aimi Y, Yasuhara O, Kimura H
    Neuropathology 19 203-208 1999年
  • Effects of an acidic fibroblast growth factor fragment analog on learning and memory and on medial septal cholinergic neurons in
    Sasaki K, Tooyama I, Li AJ, Oomura Y, Kimura H
    Neuroscience 92 1287-1294 1999年
  • Increased expression of hippocampal cholinergic neurostimulating peptide-related components and their messenger RNAs in the hippocampus of aged senescence-accelerated mice
    Matsukawa N, Tooyama I, Kimura H, Yamamoto T, Tsugu Y, Oomura Y, Ojika K
    Neuroscience 88 79-92 1999年
  • Overproduction of gamma interferon in B/Jas inbred rabbits with herpes simplex virus encephalitis.
    Yuasa T, Isono T, Tooyama I, Seto A
    Microbiol Immunol 43 365-371 1999年
  • Peripheral type choline acetyltransferase: molecular neuroanatomy
    Kimura H, Aste N, Nakajima K, Aimi Y, Yasuhara O, Tooyama I
    Ital J Anat Embryol 104(S1) 1999年
  • Immunohistochemical localization of choline acetyltransferase of a peripheral type in the rat larynx
    Nakanishi Y, Tooyama I, Yasuhara O, Aimi Y, Kitajima K, Kimura H
    J Chem Neuroanat 17 21-32 1999年
  • Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation
    Matsuoka Y, Okazaki M, Kitamura Y, Takata K, Tooyama I, Kimura H
    Brain Res 836 213-217 1999年
  • Regulation of inner ear fluid in the rat by vasopressin
    Kitano H, Suzuki M, Kitanishi T, Yazawa Y, Kitajima K, Isono T, Takeda T, Kimura H, Tooyama I
    NeuroReport 10 1205-1207 1999年
  • Interferon-g plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus
    Matsuoka Y, Kitamura Y, Takahashi H, Tooyama I, Kimura H, Gebicke-Haerter PJ, Nomura Y, Taniguchi T
    Neurochem Int 34 91-99 1999年
  • Expression of inducible nitric oxide synthase human thyroid papillary carcinoma
    Kitano H, Kitanishi T, Nakanishi Y, Suzuki M, Takeuchi E, Yazawa Y, Kitajima K, Kimura H, Tooyama I
    Thyroid 9 113-117 1999年
  • Two modes of corticospinal reinnervation occur close to spinal targets following unilateral lesion of the motor cortex in neonatal hamsters
    Aisaka A, Aimi Y, Yasuhara O, Tooyama I, Kimura H, shimada M
    Neuroscience 90 53-67 1999年
  • ナトリウム利尿ペプチド受容体
    遠山育夫, 鈴木幹男, 北野博也
    生体の科学 49 401-402 1998年
  • Actions of aFGF in senescence-accelerated mice: proctive effects against deficits of learning and memory, and effects on immun
    Li AJ, Oomura Y, Sasaki K, Hori N, Tooyama I, Nomura Y, Hanai K, Kimura H, Yanaihara N, Yoshii H, Yamazaki Y, Take T, Hori T
    Taniguchi Symposia on Brain Sciences, Brain and Biodefence 21 51-61 1998年
  • Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse
    Kitamura Y, Ota T, Matsuoka Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Shimohama S, Gebicke-Haerter PJ, Nomura U, Taniguchi
    Neurosci. Lett. 255 57-60 1998年
  • Propofol inhibits ketamine-induced c-fos expression in the rat posterior cingulate cortex
    Nagata A, Nakao S, Miyamoto E, Inada T, Tooyama I, Kimura H, Shingu K
    Aneth. Analg. 87 1416-1420 1998年
  • RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear
    Suzuki M, Kitano H, Kitanishi T, Yazawa Y, Kitajima K, Takeda T, Kimura H, Tooyama I
    Mol. Brain Res 55 165-168 1998年
  • Production of monoclonal antibody against histamine and its application to immunohistochemical study in the stomach
    Doi T, Terai K, Tooyama I, Sakata T, Kimura H
    Histochem. J. 30 425-434 1998年
  • Evaluation of focal cerebral ischemia in rats by magnetic resonance imaging and immunohistochemical analyses
    Ishii H, Arai T, Morikawa S, Inubushi T, Tooyama I, Kimura H, Mori K
    J Cereb. Blood Flow. Matab. 18 931-934 1998年
  • A single pre-training glucose injection induces memory facilitation in rodents performing various tasks: contribution of acidic fibroblast growth factor
    Li A-J, Oomura Y, Sasaki K, Suzuki K, Tooyama I, Hanai K, Kimura H, Hori T
    Neuroscience 85 785-794 1998年
  • Presence of mRNA for vasoactive intestinal polypeptide (VIP) and its receptor in the rat inner ear
    Kitano H, Takeda T, Suzuki M, Kitanishi T, Yazawa Y, Kitajima K, Kimura H, Tooyama I
    Hear. Res. 121 109-111 1998年
  • Kainic acid induction of heme oxygenase in vivo and in vitro
    Matsuoka Y, Kitamura Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Tanigushi T
    Neuroscience 85 1223-1233 1998年
  • Primary structure of GAP-43 mRNA expressed in the spinal cord of ALS patients
    Kage M, Ikemoto A, Akiguchi I, Kimura J, Matsumoto S, Kimura H, Tooyama I
    Neuroreport 9 1403-1406 1998年
  • In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase
    Kitamura Y, Furukawa M, Matsuoka Y, Tooyama I, Kimura H, Nomura Y, Taniguchi T
    Glia 22 138-148 1998年
  • Immunohistochemical localization of GABA-immunoreactive structures in the nucleus tractus solitarii of the rat
    Terai K, Tooyama I, Kimura H
    Neuroscience 82 843-852 1998年
  • Recent advances in neuroscience for Alzheimer's disease
    Kimura H, Yasuhara O, Tooyama I
    Adv. Legal. Med. 3 280-283 1997年
  • Recent Advances in Microscopy of Cells, Tissues and Organs
    Renda T, Erspamer V, Tooyama I, Kimura H
    Antonio Delfino Editore 239-246 1997年
  • Protein expression of fibroblast growth factor receptor-1 in keratinocytes during wound healing in rat skin
    Takenaka H, Kishimoto S, Tooyama I, Kimura H, Yasuno H
    J. Invest. Dermatol. 109 108-112 1997年
  • In vivo hypothermia-induced neuronal damage with an enhancement of neuronal nitric oxide synthase immunoreactivity in hippocampus
    Matsuoka Y, Kitamura Y, Tooyama I, Kimura H, Taniguchi T
    Exp. Neurol 146 57-66 1997年
  • In vivo hypothermia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801
    Matsuoka Y, Kitamura Y, Fukunaga R, Shimohama S, Nabeshima T, Tooyama I, Kimura H, Taniguchi T
    Neurochem. Int 30 533-542 1997年
  • Vasopressin and oxytocin receptor mRNAs are expressed in the rat inner ear
    Kitano H, Takeda T, Suzuki M, Kitanishi T, Yazawa Y, Kitajima K, Kimura H, Tooyama I
    Neuroreport 8 2289-2292 1997年
  • Effect of acidic fibroblast growth factor on basal forebrain cholinergic neurons in senescence accelerated mice
    Tooyama I, Sasaki K, Oomura Y, Li AJ, Kimura H
    Exp. Gerontol 32 171-179 1997年
  • Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptides (ANP-B) receptor mRNAs in rat inner ear
    Suzuki M, Kitano H, Kitanishi T, Yazawa Y, Kitajima K, Takeda T, Kimura H, Tooyama I
    Neuroreport 8 439-443 1997年
  • Memory facillitation by an endogenous satiety substance, acidic fibroblast growth factor (aFGF)
    Oomura Y, Sasaki K, Li AJ, Kimura H, Tooyama I, Hanai K, Nomura Y, Kitamura Y, Yanaihara N, Yago H
    Prog. Obes. Res. 7 433-438 1996年
  • Halotheane and diazepam inhibit katamine-induced c-fos expression in the rat cingulate cortex
    Nakao S, Adachi T, Murakawa M, Shinomura T, Kurata J, Shichino T, Shibata M, Tooyama I, Kimura H, Mori K
    Anesthesiology 85 874-882 1996年
  • Basic FGF partially prevents degeneration of paraventricular vasopressin neurons after hypophysectomy
    Takeichi Y, Nakasu Y, Tooyama I, Kimura H
    Restr. Neurol. Neurosci 10 161-166 1996年
  • In vivo induction of inducible nitric oxide synthase by microinjection with interferon-gamma and lipopolysaccharide in rat hippocampus
    Kitamura Y, Takahashi H, Matsuoka Y, Tooyama I, Kimura H, Nomura Y, Taniguch T
    Glia 18 233-243 1996年
  • Immunohistochemical demonstration of GABA-B receptors in the rat brain
    Kimura H, Terai K, Tooyama I, Kuriyama K
    Pharmacol. Rev. Comm 8 167 1996年
  • Molecular biological approaches to the GABA-B receptor
    Hirouchi M, Tooyama I, Kimura H, Kuriyama K
    Pharmacol. Rev. Comm 8 151 1996年
  • Immunohistochemical demonstration of GABA-B receptors in the rat gastrointestinal tract
    Nakajima K, Tooyama I, Kuriyama K, Kimura H
    Neurochem. Res 21 211-215 1996年
  • Protection against impairment of memory and immunoreactivity in senescence-accelerated mice by acidic fibroblast growth factor
    Oomura Y, Sasaki K, Li AJ, Yoshi H, Fukata Y, Yago H, Kimura H, Tooyama I, Hanai K, Nomura Y, Yanaihara N
    Ann. N.Y. Acad. Sci 786 337-347 1996年
  • Insulin receptor mRNA in the substantia nigra in Parkinson's disease
    Takahashi M, Yamada T, Tooyama I, Morro I, Kimura H, Yamamoto T, Okada H
    Neurosci. Lett 204 201-204 1996年
  • Expression of c-fos protein in brain and endotoxin levels in plasma following occlusion of superior mesenteric artery of rat
    Hase Takanobu, Tani Tohru, Oka Hiroshi, Yokota Tohru, Kodama Masashi, Kimura Hiroshi, Tooyama Ikuo
    The Immune Consequences of Trauma, Shock and Sepsis Mechanisms and Therapeutic Approaches 2(1) 353-358 1996年
  • Regulation of neuronal nitric oxide synthase in rat adrenal medulla
    Iwai N, Hanai K, Tooyama I, Kitamura Y, Kinosita M
    Hypertension 25 431-436 1995年
  • Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparisons
    Yasuhara O, Matsuo A, Tooyama I, Kimura H, McGeer EG, McGeer PL
    Acta Neuropathol. 89 322-330 1995年
  • Immunohistochemical localization of glucose transporters (GLUT1 and GLUT3) in the rat hypothalamus
    Yu S, Tooyama I, Ding W-G, Kitasato H, Kimura H
    Obesity Res 3 753S-760S 1995年
  • Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus
    Matsuoka Y, Kitamura Y, Tsukihara T, Terai K, Tooyama I, Kimura H, Taniguchi T
    Neuroreport 6 2205-2208 1995年
  • Demonstration of fibroblast growth factor receptor-1 in human prostate by polymerase chain reaction and immunohistochemistry
    Hamaguchi A, Tooyama I, Yoshiki T, Kimura H
    Prostate 27 141-147 1995年
  • Subcellular localization low density lipoprotein receptor-related protein (alpha-2 macroglobulin receptor) in human brain
    Tooyama I, Kawamata T, Akiyama H, Kimura H, Moestrup SK, Gliemann J, Matsuo A, McGeer PL
    Brain Res 691 235-238 1995年
  • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
    Moroo I, Yamada T, Makino H, Tooyama I, McGeer PL, McGeer EG, Hirayama K
    Acta Neuropath. 87 343-348 1994年
  • Neuropeptide Y-containing nerves in the mammalian liver and liver disease
    Ding W-G, Kitasato H, Fujimura M, Tooyama I, Kimura H
    Biomed.Res 15(supple 2) 283-287 1994年
  • Immunohistochemical localization of taurine-conjugated bile acids in the liver of mouse, rat, monkey and human
    Ding WG, Tooyama I, Kimura H, Kuriyama K
    Adv. Exp. Med. Biol 359 91-98 1994年
  • Acidic FGF expression in the surroundings of senile plaques
    Kimura H, Tooyama I, McGeer PL
    Tohoku J. Exp. Med 174 279-293 1994年
  • Phylogenetic and ontogenetic study of neuropeptide Y-containing nerves in the liver
    Ding W-G, Tooyama I, Kitasato H, Fujimura M, Kimura H
    Histochem. J 26 453-459 1994年
  • Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarction
    Hara Y, Tooyama I, Yasuhara O, Akiyama H, McGeer PL, Hande J, Kimura H
    Brain Res 664 101-107 1994年
  • Lignocaine-induced convulsion does not induce c-fos protein (c-Fos) in rat hippocampus
    Nakao S, Kurata J, Arai T, Murakawa M, Adachi T, Avramov MN., Mori K, Yasuhara O, Tooyama I, Kimura H
    Acta Anaesthesiologica Scandinavica 38 845-851 1994年
  • Effects of fibroblast growth factors and related peptides on food intake by rats
    Sasaki K, A.J. Li, Oomura Y, Muto T, Hanai K, Tooyama I, Kimura H, Yanaihara N, Yagi H, Hori T
    Physiol. Behav 56 211-218 1994年
  • Retention of basic fibroblast growth facter immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrasts with loss in Parkinson's disease
    Tooyama I, Kawamata T, Kimura H, McGeer PL, McGeer EG
    Brain Res 656 165-168 1994年
  • Postnatal development of [D-Ala2]deltorphin-I immunoreactive structures in the rat brain
    Nonomura N, Tooyama I, Abe H, Renda T, Erspamer V, Shibata M, Kimura H
    J. Comp. Neurol 349 223-243 1994年
  • Effects of neopterin on ischemic neuronal damage in gerbils
    Arai T, Watanabe K, Nakao S, Mori H, Mori K, Tooyama I, Kimura H, Kojima S
    Neurosci. Lett 173 107-110 1994年
  • Immunohistochemical demonstration of [D-Ala2]deltorphin I in amacrine cells of rat retina
    Abe H, Tooyama I, Renda T, Erspamer V, Kimura H
    Peptides 15 49-54 1994年
  • Early response of brain resident microglia to kainic acid-induced hippocampal lesions
    Akiyama H, Tooyama I, Kondo H, Ikeda K, Kimura H, Mcgeer EG, Mcgeer PL
    Brain Res 635 257-268 1994年
  • Microglia in degenerative neurological disease
    McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG
    Glia 7 84-92 1993年
  • Columnar arrangement of
    Akiyama H, Yamada T, McGeer PL, Kawamata T, Tooyama I, Ishii T
    Acta Nueropathol. 85 400-403 1993年
  • Immunohistochemical study of alpha2 macroglobulin receptor in Alzheimer and control postmortem human brain
    Tooyama I, Kawamata T, Akiyama H, Moestrup SK, Gliemann J, McGeer PL
    Mol. Chem. Neuropathol. 18 153-160 1993年
  • Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerativ
    Akiyama H, Kawamata T, Yamada T, Tooyama I, Ishii T, McGeer PL
    Acta Neuropathol. 85 628-634 1993年
  • Lactotransferrin immunocytochemistry in Alzheimer and normal human brain
    Kawamata T, Tooyama I, Yamada T, Walker DG, McGeer PL
    Am. J. Pathol. 142 1574-1585 1993年
  • [D-Ala2]deltorphin I-like immunoreactivity in adult rat brain: Immunohistochemical localization
    Tooyama I, Abe H, Renda T, Erspamer V, Kimura H
    Proc. Natl. Acad. Sci. (U.S.A.) 90 9635-9639 1993年
  • Autoradiographic study on [3H]-[D-Ala2]-Deltorphin-I binding sites in the rat brain
    Renda T, Negri L, Tooyama I, Casu C, Melchiorri P
    Neuroreport 4 1143-1146 1993年
  • Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's di
    Akiyama H, Tooyama I, Kawamata T, Ikeda K, McGeer PL
    Brain Res. 63 249-259 1993年
  • Phylogenetic Study of Neuropeptide Y-Containing Nerves in the Liver.
    Fujimura M, Ding WG, Kitasato H, Tooyama I, Kimura H
    The International Conference on Gut Hormone (GUT HORMONE  1993年
  • Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels
    Snow BJ, Tooyama I, Mcgeer EG, Yamada T, Calne DB, Takahashi H, Kimura H
    Ann. Neurol 34 324-330 1993年
  • High-dose ketamine does not induce c-Fos protein expression in rat hippocampus
    Nakao S, Arai T, Mori K, Yasuhara O, Tooyama I, Kimura H
    Neurosci. Lett 151 33-36 1993年
  • Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease.
    Tooyama I, Kawamata T, Walker D, Yamada T, Hanai K, Kimura H, Igarashi K, McGeer EG, McGeer PL
    Neurology 43 372-376 1993年
  • Distribution of taurine-like immunoreactivity in the mouse liver during ontogeny and after carbon tetrachloride or phenobarbital intoxication.
    Ding WG, Tooyama I, Kimura H, Kuriyama K, Ochi J
    The Histochemical Journal 25 376-383 1993年
  • Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease.
    Tooyama I, Kremer HPH, Hayden MR, Kimura H, McGeer EG, McGeer PL
    Brain Res. 610 1-7 1993年
  • A new brain glucosensor and its physiological significance
    Oomura Y, Sasaki K, Suzuki K, Muto T, Li A-J, Ogita Z, Hanai K, Tooyama I, Kimura H, Yanaihara N
    Am. J. Clin. Nutr. 55 278-282 1992年
  • High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain.
    Tooyama I, Walker D, Yamada T, Hanai K, Kimura H, McGeer EG, McGeer PL
    Brain Res. 593 274-280 1992年
  • Production of antiserum to [D-Ala2]deltorphin I and its immunohistochemical application to the mouse brain.
    Abe H, Tooyama I, Renda T, Ersparmer V, Kimura H
    Neuroreport 3 669-672 1992年

書籍等出版物

  • 分子遺伝学の基礎   神経内科テキスト(改訂第2版)
    南江堂 2005年
  • 神経内科学テキスト
    南江堂 2000年
  • 神経伝達物質update-基礎から臨床まで
    中外医学社 1998年
  • The Bioligy of Nitric Oxide
     1998年

MISC

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    Modern Physician 25 1058-1062 2005年
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    日本臨床  62 supple 46-51 2004年
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    遠山育夫, 岩見美香, 豊田健一郎, 相見良成
    Clinical Neuroscience 22 293-296 2004年
  • Interaction of alpha2-macroglobulin and amyloid beta peptide. In: Neuroinflammatory Mechanisms in Alzheimer's disease
    Tooyama I
    Birkhauser Verlag 145-154 2001年
  • 海馬損傷 けいれんの動物モデルにおけるグリア細胞の活性化ートリメチル錫投与モデルとカイニン酸投与モデルの比較から
    加藤 進昌, 金井 裕彦, 西村 敏, 植村 秀治, 遠山 育夫, 木村 宏, 池田 正行
    なし 0 0-0 1997年
  • Expression of c-fos protein in rat brain following occlusion of mesenteric artery: analysis of a humoral factor
    Hase Takanobu, Tani Tohru, Oka Hiroshi, Yokota Tohru, Kodama Masashi, Kimura Hiroshi, Tooyama Ikuo
    5th vienna shock forum 1995年
  • Expression of c-fos protein in rat brain following occlusion of superior mesenteric artery(SMAO): involvement of a humoral facto
    Hase Takanobu, Tani Tohru, Oka Hiroshi, Yokota Tohru, Kodama Masashi, Kimura Hiroshi, Tooyama Ikuo
    3rd international shock congress shock 1995年
  • ラット上腸間膜動脈結紮後における中枢神経内c-fos発現について(免疫組織学的検討)
    長谷貴將, 小玉正智, 谷徹, 吉岡豊一, 岡浩, 木村宏, 遠山育夫
    第94回日本外科学会総会 1994年
  • ラット上腸間膜動脈結紮後における中枢神経内c-fos発現と血中エンドトキシン濃度について
    長谷貴將, 谷徹, 小玉正智, 岡浩, 横田徹, 遠山育夫, 木村宏
    第44回日本消化器外科学会総会 1994年

受賞

  • 2006年 加藤記念難病研究基金平成18年度研究奨励賞
  • 2006年 日本脳科学会研究奨励賞

競争的資金

  • アルツハイマー病の診断・治療法に関する研究
  • 認知症の神経病理学的研究
  • コリン神経の分子科学

その他

  • 1989 年以前は(Tohyama Ikuo)内の研究名を使用