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野﨑 和彦

所属部署名脳神経外科学講座
職名教授
 
 
更新日: 18/03/30 10:26

研究者基本情報

氏名

    野﨑 和彦

所属(マスタ)

  • 脳神経外科学講座 教授

学歴

  • - 1990年京都大学 医学研究科
  • - 1983年京都大学 医学部

学位

  • 医学博士(京都大学)

所属学協会

    日本心血管脳卒中学会(学術評議員) , 日本脳ドック学会(評議員) , 日本脳神経CI学会(世話人) , 日本脳神経外科術中画像学会(理事) , 米国脳神経外科学会(国際会員) , 米国コングレス(国際会員) , 日本脳神経外科学会(代議員、学術委員長) , 日本脳卒中学会(幹事) , 日本脳卒中の外科学会(代議員) , 日本脳腫瘍の外科学会(理事、学術委員長) , 日本頭蓋底外科学会(理事) , 脳神経外科手術と機器学会(監事)

委員歴

  • - 現在日本脳卒中学会 幹事
  • - 現在日本脳神経外科学会 学術委員会委員長、ガイドライン対応委員会委員長、医療機器委員会副委員長、専門医認定委員、生涯教育委員会委員、機関紙NMC編集委員会委員、分科会検討委員会委員、研究倫理審査委員会委員など
  • 脳神経外科手術と機器学会 運営委員 監事
  • 日本頭蓋底外科学会 理事
  • 日本脳腫瘍の外科学会 理事 学術委員会委員長 あり方委員会委員
  • 日本脳卒中の外科学会 代議員
  • 日本脳卒中学会 代議員、幹事
  • 日本脳神経外科学会 代議員、生涯教育委員、専門医認定委員、医療器機委員

経歴

  • 平成20年 滋賀医科大学医学部脳神経外科教授(2月1日)
  • 平成19年 京都大学医学部脳神経外科准教授
  • 平成11年 京都大学医学部脳神経外科講師(7月16日)平成15年 京都大学医学部脳神経外科助教授(7月1日)
  • 平成 5年 京都大学医学部附属病院脳神経外科助手(4月1日)

研究活動情報

研究分野

  • 外科系臨床医学 / 脳神経外科学

研究キーワード

    脳脊髄腫瘍 , 頭蓋底腫瘍 , 脳動脈瘤、脳動静脈奇形

論文

  • The Association between Glomerular Filtration Rate Estimated on Admission and Acute Stroke Outcome: The Shiga Stroke Registry.
    Widhi Nugroho A, Arima H, Miyazawa I, Fujii T, Miyamatsu N, Sugimoto Y, Nagata S, Komori M, Takashima N, Kita Y, Miura K, Nozaki K
    Journal of atherosclerosis and thrombosis 2018年01月 [査読有り]
  • Incidence, Management and Short-Term Outcome of Stroke in a General Population of 1.4 Million Japanese - Shiga Stroke Registry.
    Takashima N, Arima H, Kita Y, Fujii T, Miyamatsu N, Komori M, Sugimoto Y, Nagata S, Miura K, Nozaki K
    Circulation journal : official journal of the Japanese Circulation Society 81(11) 1636-1646 2017年10月 [査読有り]
  • Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients.
    Aoki T, Saito M, Koseki H, Tsuji K, Tsuji A, Murata K, Kasuya H, Morita A, Narumiya S, Nozaki K, MR Macrophage Imaging Study Investigators.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 26(10) 2055-2064 2017年10月 [査読有り]
  • Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of worse survival after resection in patients with brain metastasis.
    Mitsuya K, Nakasu Y, Kurakane T, Hayashi N, Harada H, Nozaki K
    Journal of neurosurgery 127(2) 433-437 2017年08月 [査読有り]
  • A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration.
    Yamamoto R, Aoki T, Koseki H, Fukuda M, Hirose J, Tsuji K, Takizawa K, Nakamura S, Miyata H, Hamakawa N, Kasuya H, Nozaki K, Hirayama Y, Aramori I, Narumiya S
    British journal of pharmacology 174(13) 2085-2101 2017年07月 [査読有り]
  • Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms.
    Aoki T, Frȍsen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E, Nozaki K, Laakkonen J, Narumiya S
    Science signaling 10(465) 2017年02月 [査読有り]
  • T cell function is dispensable for intracranial aneurysm formation and progression.
    Miyata H, Koseki H, Takizawa K, Kasuya H, Nozaki K, Narumiya S, Aoki T
    PloS one 12(4) e0175421 2017年 [査読有り]
  • Preemptive Medicine for Cerebral Aneurysms.
    Aoki T, Nozaki K
    Neurologia medico-chirurgica 56(9) 568 2016年09月 [査読有り]
  • mTORC1 signaling in primary central nervous system lymphoma.
    Nitta N, Nakasu S, Shima A, Nozaki K
    Surgical neurology international 7(18) S475-S480 2016年07月 [査読有り]
  • Primary pericranial Ewing's sarcoma on the temporal bone: A case report.
    Kawano H, Nitta N, Ishida M, Fukami T, Nozaki K
    Surgical neurology international 7(16) S444-S448 2016年06月 [査読有り]
  • Straight sinus thrombosis during neurosurgical operation.
    Kawano H, Nitta N, Nozaki K
    Surgical neurology international 7(1) 2016年05月 [査読有り]
  • Trigeminal Neuralgia Attributable to Intraneural Trigeminocerebellar Artery: Case Report and Review of the Literature.
    Jito J, Nozaki K
    World neurosurgery 88 7-11 2016年04月 [査読有り]
  • Direct Microsurgical Embolectomy for Acute Occlusion of the Internal Carotid Artery and Middle Cerebral Artery.
    Hino A, Oka H, Hashimoto Y, Echigo T, Koseki H, Fujii A, Katsumori T, Shiomi N, Nozaki K, Arima H, Hashimoto N
    World neurosurgery 88 243-251 2016年04月 [査読有り]
  • [Arteriovenous Malformation Treatment after ARUBA study].
    Tsuji A, Nakazawa T, Nozaki K
    No shinkei geka. Neurological surgery 44(4) 269-281 2016年04月 [査読有り]
  • Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor.
    Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, Fukuda M, Saiki M, Hojo M, Miyamoto S, Onishi N, Saya H, Inubushi T, Nozaki K, Tanigaki K
    PloS one 11(2) 2016年02月 [査読有り]
  • A Prospective and Retrospective Study of Cerebral AVM Treatment Strategies 1990-2014.
    Tsuji A, Nozaki K
    Acta neurochirurgica. Supplement 123 135-139 2016年 [査読有り]
  • Recurrent subdural hematoma secondary to headbanging: A case report.
    Nitta N, Jito J, Nozaki K
    Surgical neurology international 6 S448-S450 2015年10月 [査読有り]
  • Statin use and risk of cerebral aneurysm rupture: a hospital-based case-control study in Japan
    YOSHIMURA Yayoi, MURAKAMI Yoshitaka, SAITOH Makoto, YOKOI Toshihiro, AOKI Tomohiro, MIURA Katsuyuki, MIURA Katsuyuki, UESHIMA Hirotsugu, UESHIMA Hirotsugu, NOZAKI Kazuhiko
    J Stroke Cereb Vasc Dis 23(2) 343-348 2014年
  • Selection of semi-sitting position in neurosurgery: Essential or preference?
    Nozaki K.
    World Neurosurgery 81(1) 62-63 2014年
  • Role of burr hole surgery in patients with moyamoya disease.
    Nozaki K.
    World Nuerosurgery 81(1) 27-28 2014年
  • Suppression of cerebral aneurysm formation in rats by a tumor necrosis factor-a inhibitor
    Yokoi T., Saitoh M., Isono T., Nozaki K., Yoshimura Y.
    J Neurosurg 120(5) 1193-1200 2014年
  • Morphometric characterization of Binswanger's disease: Comparison with Alzheimer's disease.
    Shiino A., Watanabe T., Akiguchi I., Nozaki K., Shirakashi Y., Inubushi T., Tooyama I.
    Eur J Radiol 81(9) 2375-2379 2012年
  • Surgical Intervention for Cerebral Ischemia: Effective or not?
    NOZAKI Kazuhiko
    World Neurosurgery  78(1-2) 45-46 2012年
  • Intra-arterial infusion therapy for cerebral vasospasm: promising but preliminary
    NOZAKI Kazuhiko
    World Neurosurgery  78(3-4) 223-225 2012年
  • Transplantation of telencephalic neural progenitors induced from embryonic stem cells into subacute phase of focal cerebral ischemia.
    FUJIMOTO Motoaki, HAYASHI Hideki, TAKAGI Yasushi, HAYASE Makoto, MARUMO Takeshi, GOMI Masanori, NISHIMURA Masaki, KATAOKA Hiroharu, TAKAHASHI Jun, HASHIMOTO Nobuo, NOZAKI Kazuhiko, MIYAMOTO Susumu
    Lab Invest 92(4) 522-531 2012年
  • The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort.
    Yoshimoto T., Tominari S., Morita A., Hashi K., Kirino T., Fukuhara S., Aoki N., Nakayama T., Hashimoto N., Teramoto A., Sakai M.
    N Engl J Med 366(26) 2474-2782 2012年
  • Inadequate communication between patients with unruptured cerebral aneurysms and neurosurgeons
    SAITO Makoto, TAKAHASHI Yoshimitsu, YOSHIMURA Yayoi, SHIMA Ayako, MORITA Akio, HOUKIN Kiyohiro, NAKAYAMA Takeo, NOZAKI Kazuhiko
    Neurol Med Chir (Tokyo) 52(12) 873-877 2012年
  • Growth curve analysis of asymptomatic and symptomatic meningiomas.
    NOZAKI K, JITO J, FUKAMI T, NAKASU Y, NAKASU S
    J Neurooncol 102(2) 303-310 2011年
  • Aoki T, Nishimura M, Matsuoka T, Yamamoto K, Furuyashiki T, Kataoka H,Kitaoka S, Ishibashi R, Ishibazawa A, Miyamoto S, Morishita R, Ando J,
    PGE(2) -EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB.(163) 1237-1249 2011年
  • Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS.
    AOKI Tomohiro, NISHIMURA Masaki, KATAOKA Hiroharu, ISHIBASHI Ryota, NOZAKI Kazuhiko, MIYAMOTO Susumu
    Lab Invest  91(4) 619-626 2011年
  • Benefits and risks of radiosurgery to brainstem arteriovenous malformations
    NOZAKI Kazuhiko
    World Neurosurgery 76(1-2) 57-58 2011年
  • Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells.
    GOMI Masanori, AOKI Tomohiro, TAKAGI Yasushi, NISHIMURA Masaki, OHSUGI Yoshiyuki, MIHARA Masahiko, NOZAKI Kazuhiko, NOZAKI Kazuhiko, HASHIMOTO Nobuo, MIYAMOTO Susumu, TAKAHASHI Jun
    J Neurosci Res 89(9) 1388-1399 2011年
  • Transdifferentiation of bone marrow-derived endothelial progenitor cells into the
    IMAMURA H., DOI K., TAKAGI Y., OHTA T., TSUNETOSHI K., KIKUTA K.‐I., NOZAKI K.
    Atherosclerosis 211(1) 114-121 2010年
  • Practical Decision-Making in the Treatment of Unruptured Cerebral Aneurysm in Japan: The U-CARE Study.
    HASHIMOTO N, NOZAKI K, HOUKIN K, AKIYAMA Y
    Cerebrovasc Dis 30(5) 491-499 2010年
  • Impact of monocyte chemoattractant protein-1-deficiency on cerebral aneurysm formation.
    HASHIMOTO N, EGASHIRA K, NOZAKI K, ISHIBASHI R, KATAOKA H, AOKI T
    Stroke 40(3) 942-951 2009年
  • Reactive oxygen species are responsible for cerebral aneurysm formation: study using p47phox-/- mice and the free radical scavenger 'edaravone'
    AOKI Tomohiro, NISHIMURA Masaki, KATAOKA Hiroharu, ISHIBASHI Ryota, NOZAKI Kazuhiko, HASHIMOTO Nobuo
    Laboratory Investigation 89(7) 730-741 2009年
  • Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia.
    TAKAGI Y, NOZAKI K, HASHIMOTO N, YODOI J, MASUTANI H, MARUMO T, ZHOU F, GOMI M, FUJIMOTO M, HAYASE M
    Brain Res 1272 62-70 2009年
  • Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke.
    HAYASE Makoto, KITADA Masaaki, KITADA Masaaki, WAKAO Shohei, WAKAO Shohei, ITOKAZU Yutaka, NOZAKI Kazuhiko, NOZAKI Kazuhiko, HASHIMOTO Nobuo, HASHIMOTO Nobuo, TAKAGI Yasushi, DEZAWA Mari, DEZAWA Mari
    J Cereb Blood Flow Metab 29(8) 1409-1420 2009年
  • RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis
    FUJIMOTO Motoaki, FUJIMOTO Motoaki, TAKAGI Yasushi, MURAKI Kazue, NOZAKI Kazuhiko, YAMAMOTO Norio, TSUJI Masayuki, HASHIMOTO Nobuo, HONJO Tasuku, TANIGAKI Kenji
    Dev Biol 332(2) 339-350 2009年
  • Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme.
    AOKI Tomokazu, MIZUTANI Tomohiko, NOJIMA Kuniharu, TAKAGI Takehisa, OKUMURA Ryosuke, YUBA Yoshiaki, UEBA Tetsuya, TAKAHASHI Jun A., MIYATAKE Shin-Ichi, NOZAKI Kazuhiko, TAKI Waro, MATSUTANI Masao
    J Neurosurg 112(1) 50-56 2009年
  • Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm. Contribution of Interleukin-1{beta} and Nuclear Factor-{kappa}B.
    AOKI Tomohiro, KATAOKA Hiroharu, ISHIBASHI Ryota, NOZAKI Kazuhiko, MORISHITA Ryuuichi, HASHIMOTO Nobuo
    Arterioscler Thromb Vasc Biol  29(7) 1080-1086 2009年
  • Autosomal dominant moyamoya disease maps to chromosome 17q25.3
    Neurology(70) 2357-2363 2008年
  • Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats
    Aoki T., Ishibashi R., Kataoka H., Hashimoto N., Nozaki K.
    Stroke  39(4) 1276-1285 2008年
  • Effect of early optic canal unroofing on the outcome of visual functions in surgery for meningiomas of the tuberculum sellae and planum sphenoidale
    HASHIMOTO N, TAKAHASHI Ja, MINEHARU Y, TAKAGI Y, KIKUTA K, NOZAKI K
    Neurosurgery 62(4) 839-844 2008年
  • Cathepsin B, K and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms
    AOKI T, KATAOKA H, ISHIBASHI R, NOZAKI K, HASHIMOTO N
    Stroke 39(9) 2603-2610 2008年
  • Tissue Inhibitor of Metalloproteinases Protect Blood Brain Barrier Disruption in Focal Cerebral Ischemia
    NOZAKI K, HASHIMOTO N, KATAOKA H, NISHIMURA M, GOMI M, MARUMO T, HAYASE M, AOKI T, TAKAGI Y, FUJIMOTO M
    J Cereb Blood Flow Metab 28(10) 1674-1685 2008年
  • Gene Expression during the Development of Experimentally Induced Cerebral Aneurysms
    SADAMASA N, NOZAKI K, KITA-MATSUO H, SAITO S, MORIWAKI T, AOKI T, KAWARAZAKI S, KATAOKA H, TAKAGI Y, ISHIKAWA M, HASHIMOTO N, KATO K
    J Vasc Res 45(4) 343-349 2008年
  • Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23
    MINEHARU Yohei, INOUE Kayoko, INOUE Sumiko, KIKUCHI Kenji, OHISHI Hikaru, NOZAKI Kazuhiko, HASHIMOTO Nobuo, KOIZUMI Akio
    J Hum Genet 53(4) 325-332 2008年
  • Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappa B pathway
    HASHIMOTO N, MORISHITA R, NOZAKI K, NAKAGAMI H, ISHIBASHI R, KATAOKA H, AOKI T
    Neurosurgery  64(2) 357-365 2008年
  • Nifedipine Inhibits the Progression of An Experimentally Induced Cerebral Aneurysm in Rats with Associated Down-Regulation of NF-Kappa B Transcriptional Activity.
    Aoki T., Ishibashi R., Kataoka H., Hashimoto N., Nozaki K.
    Curr Neurovasc Res 5 5(1) 37-45 2008年
  • The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation.
    Int J Mol Med 21(4) 453-459 2008年
  • Targeted disruption of Hsp110/105 gene protects against ischemic stress
    NAGATA K, HOSOKAWA N, NOZAKI K, TAKAGI Y, HATAYAMA T, AKIRA S, TAKEDA K, YASUDA K, FUJIMOTO M, NAKAMURA J
    Stroke 39(10) 2853-2859 2008年
  • Cerebral aneurysm progression suppressed by blockage of endothelin B receptor
    SADAMASA N, NOZAKI K, TAKAGI Y, MORIWAKI T, KAWANABE Y, ISHIKAWA M, HASHIMOTO N
    J Neurosurg 106(2) 330-336 2007年
  • Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats
    OHTA T, KIKUTA Ki, IMAMURA H, TAKAGI Y, NISHIMURA M, ARAKAWA Y, HASHIMOTO N, NOZAKI K
    Neurosurgery 59(3) 679-685 2007年
  • Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats
    AOKI T, KATAOKA H, MORIMOTO M, NOZAKI K, HASHIMOTO N
    Stroke  38(1) 162-169 2007年
  • Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm
    MINEHARU Y, INOUE K, INOUE S, YAMADA S, NOZAKI K, HASHIMOTO N, KOIZUMI A
    Stroke 38(4) 1174-1178 2007年
  • Neuronal expression of Fas-associated death domain protein and caspase-8 in the perinidal parenchyma of cerebral arteriovenous malformations
    TAKAGI Y, KIKUTA K, NOZAKI K, FUJIMOTO M, HAYASHI J, HASHIMOTO N
    J Neurosurg 106(2) 275-282 2007年
  • Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms.
    AOKI T, KATAOKA H, MORIWAKI T, NOZAKI K, HASHIMOTO N
    Stroke  38(8) 2337-2345 2007年
  • alpha-Klotho as a regulator of calcium homeostasis
    IMURA Akihiro, IMURA Akihiro, TSUJI Yoshihoto, MURATA Miyahiko, MAEDA Ryota, KUBOTA Koji, IWANO Akiko, IWANO Akiko, OBUSE Chikashi, TOGASHI Kazuya, TOMINAGA Makoto, KITA Naoko, TOMIYAMA Ken‐ichi, IIJIMA Junko, NABESHIMA Yoko, FUJIOKA Makio, ASATO Ryo, TANAKA Shinzo, KOJIMA Ken, ITO Juichi, NOZAKI Kazuhiko, HASHIMOTO Nobuo, ITO Tetsufumi, NISHIO Takeshi, UCHIYAMA Takashi, FUJIMORI Toshihiko, FUJIMORI Toshihiko, NABESHIMA Yo‐ichi, NABESHIMA Yo‐ichi
    Science 316(5831) 1615-1618 2007年
  • Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations
    YAMADA S, TAKAGI Y, NOZAKI K, KIKUTA Ki, HASHIMOTO N
    J Neurosurg 107(5) 965-972 2007年
  • NF-(kappa)B is a key mediator of cerebral aneurysm formation
    HASHIMOTO N, MORISHITA R, NOZAKI K, ISHIBASHI R, MORIWAKI T, WAKAYAMA K, NAKAGAMI H, SHIMAMURA M, KATAOKA H, AOKI T
    Circulation 116(24) 2830-2840 2007年
  • Proliferarive activity through extracellular signal-regulated kinase of smooth muscle cells in the vascular walls of cerebral arteriovenous malformations
    TAKAGI Y, KIKUTA K, SADAMASA N, NOZAKI K, HASHIMOTO N
    Neurosurgy  58(4) 740-747 2006年
  • Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 To Intracranial Aneurysm
    MINEHARU Y, INOUE K, INOUE S, YAMADA S, NOZAKI K, TAKENAKA K, HASHIMOTO N, KOIZUMI A
    Stroke 37(5) 1189-1194 2006年
  • Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain
    HAYASHI J, TAKAGI Y, FUKUDA H, IMAZATO T, NISHIMURA M, FUJIMOTO M, TAKAHASHI J, HASHIMOTO N, NOZAKI K
    J Cereb blood Flow Metab 26(7) 906-914 2006年
  • Impaired progression of cerebral aneurysms in interleukin-1b-deficient mice
    MORIWAKI T, TAKAGI Y, SADAMASA N, AOKI T, NOZAKI K, HASHIMOTO N
    Stroke 37(3) 900-905 2006年
  • Surgical application to arteriovenous malformations involving the brainstem
    NOZAKI K, HASHIMOTO N, KIKUTA K, TAKAGI Y, KIKUCHI H
    Neurosurgery 58(4) 270-278 2006年
  • Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for Intracranial aneurysm: a preliminary study
    INOUE K, MINEHARU Y, INOUE S, YAMADA S, MATSUDA F, NOZAKI K, TAKENAKA K, HASHIMOTO N, KOIZUMI A
    Circulation 113(16) 2002-2010 2006年
  • Optic strut as a radiographic landmark in evaluating neck location of a paraclinoid aneurysm
    HASHIMOTO K, NOZAKI K, HASHIMOTO N
    Neurosurgery 59(4) 880-885 2006年
  • Caspase-3-dependent apoptosis in middle cerebral arteries in patients with moyamoya disease
    TAKAGI Y, KIKUTA Ki, SADAMASA N, NOZAKI K, HASHIMOTO N
    Neurosurgery 59(4) 894-900 2006年
  • Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting
    MINEHARU Y, TAKENAKA K, YAMAKAWA H, INOUE K, IKEDA H, KIKUTA Ki, TAKAGI Y, NOZAKI K, HASHIMOTO N, KOIZUMI A
    J Neurology Neurosurgery Psychiatry 77(9) 1025-1029 2006年
  • Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain
    TAKAGI Y, NISHIMURA M, MORIZANE A, TAKAHASHI J, NOZAKI K, HAYASHI J, HASHIMOTO N
    J Neurosurg 103(2) 304-310 2005年
  • Dual roles for DNA polymerase h in homologous DNA recombination and translesion DNA synthesis
    KAWAMOTO Takuo, ARAKI Kasumi, ARAKI Kasumi, SONODA Eiichiro, YAMASHITA Yukiko M., HARADA Kouji, KIKUCHI Koji, MASUTANI Chikahide, HANAOKA Fumio, HANAOKA Fumio, NOZAKI Kazuhiko, HASHIMOTO Nobuo, TAKEDA Shunichi
    Mol Cell 20(5) 793-799 2005年
  • High Expression of Aurora-B/Aurora and Ipl1-like midbody-associated protein (AIM-1) in astrocytomas
    ARAKI K, NOZAKI K, UEBA T, TATSUKA M, HASHIMOTO N
    J Neurooncol 67(1-2) 53-64 2004年
  • Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane
    IMURA A, IWANO A, TOHYAMA O, TSUJI Y, NOZAKI K, HASHIMOTO N, FUJIMORI T, NABESHIMA Y
    FEBS Lett 565(1/3) 143-147 2004年
  • Genome-Wide Scan for Japanese Familial Intracranial Aneurysms: Linkage to Several Chromosomal Regions
    YAMADA S, UTSUNOMIYA M, INOUE K, NOZAKI K, INOUE S, TAKENAKA K, HASHIMOTO N, KOIZUMI A
    Circulation 110(24) 3727-3733 2004年
  • Adenovirus-mediated gene transfer of fibroblast growth factor-2 increases BrdU-positive cells after forebrain ischemia in gerbils
    MATSUOKA N, NOZAKI K, TAKAGI Y, NISHIMURA M, HAYASHI J, MIYATAKE Si, HASHIMOTO N
    Stroke 34(6) 1519-1525 2003年
  • Absence of linkage of familial intracranial aneurysms to 7q.11 in highly aggregated Japanese families
    YAMADA S, UTSUNOMIYA M, INOUE K, NOZAKI K, MIYAMOTO S, HASHIMOTO N, TAKENAKA K, YOSHINAGA T, KOIZUMI A
    Stroke 34(4) 892-900 2003年
  • Control of axon elongation via an SDF-1a/Rho/mDia pathway in cultured cerebellar granule neurons
    ARAKAWA Y, BITO H, FURUYASHIKI T, TSUJI T, TAKEMOTO‐KIMURA S, KIMURA K, NOZAKI K, HASHIMOTO N, NARUMIYA S
    J Cell Biol 161(2) 381-391 2003年
  • Involvement of extracellular Ca2+ influx and epidermal growth factor receptor tyrosine kinase transactivation in endothelin-1-induced arachidonic acid release
    KAWANABE Y, NOZAKI K, HASHIMOTO N, MASAKI T
    Br J Pharmacol 139(8) 1516-1522 2003年
  • Activation of p38 kinase in the gerbil hippocampus showing ischemic tolerance
    J Cereb Blood Flow Metab(23) 1052-1059 2003年
  • Disruption of gene for inducible nitric oxide synthase reduces progression of cerebral aneurysms.
    SADAMASA N, NOZAKI K, HASHIMOTO N
    Stroke 34(12) 2980-2984 2003年
  • Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant Endothelin A receptor
    KAWANABE Y, OKAMOTO Y, NOZAKI K, HASHIMOTO N, MIWA S, MASAKI T
    Molecular Pharmacol  61(2) 277-284 2002年
  • Mitogen-activated protein kinases and cerebral ischemia
    Molecular Neurobiology(23) 1-19 2001年
  • Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus
    J Neurosci (20) 4506-4514 2000年
  • Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase
    Circulation(101) 2532-2538 2000年
  • Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage
    TAKAGI Y, MITSUI A, NISHIYAMA A, NOZAKI K, SONO H, GON Y, HASHIMOTO N, YODOI J
    Proc Natl Acad Sci (USA)  96(7) 4131-4136 1999年
  • Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat: Immunohistochemical and hybridization studies of thioredoxin
    J Cereb Blood Flow Metab(18) 206-214 1998年
  • Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries
    Laboratory Investigation(78) 957-966 1998年
  • Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain
    Journal Cerebral Blood Flow & Metabolism(18) 991-997 1998年
  • Expression of c-fos-like immunoreactivity in brain stem after meningeal irritation by blood in the subarachnoid space
    Neuroscience(49) 669-680 1993年
  • Neocortical spreading depression provokes the expression of c-fos-like immunoreactivity within trigeminal nucleus caudalis
    Journal of Neuroscience(13) 1167-1177 1993年
  • Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries
    Journal of Cerebral Blood Flow and Metabolism (13) 70-79 1993年
  • Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats
    Journal of Cerebral Blood Flow and Metabolism(13) 221-228 1993年
  • Neuroprotective effects of l-kynurenine on hypoxia-ischemia and NMDA
    Journal of Cerebral Blood Flow and Metabolism(12) 400-407 1992年
  • CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges
    British Journal of Pharmacology(106) 409-415 1992年
  • Vascular relaxation properties of calcitonin gene-related peptide and vasoactive intestinal polypeptide in subarachnoid hemorrhage
    Journal of Neurosurgery(72) 792-797 1990年
  • Origins and distribution of cerebrovascular nerve fibers showing calcitonin gene-related peptide-like immunoreactivity in the major cerebral artery of the dog
    Journal of Comparative Neurology(297) 212-226 1990年

MISC

  • Critical role of TNF-alpha-TNFR1signaling in intracranial aneurysm formation.
    Aoki T., Nishimura M., Fukuda M., Narumiya S., Nozaki K.
    Acta Neuropathologica Communications 2(1) 2014年

受賞

  • 2001年 第9回日本脳卒中の外科学会賞
  • 1990年 第49回日本脳神経外科学会ガレーヌス賞

競争的資金

  • 脳動脈瘤研究、脳虚血研究、脳腫瘍研究