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久米 真司

所属部署名内科学講座(腎臓内科)
職名助教
 
 
更新日: 18/07/17 17:00

研究者基本情報

氏名

    久米 真司

所属(マスタ)

  • 内科学講座(腎臓内科) 助教

学位

  • 医学博士

研究活動情報

論文

  • Emerging role of mammalian autophagy in ketogenesis to overcome starvation.
    Takagi A, Kume S, Maegawa H, Uzu T.
    Autophagy 12(4) 709-710 2016年04月 [査読有り]
  • Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy.
    Tagawa A, Yasuda M, Kume S, Yamahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T.
    Diabetes.  65(3) 755-767 2016年03月 [査読有り]
  • Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury.
    Tanaka Y, Kume S, Chin-Kanasaki M, Araki H, Araki S, Ugi S, Sugaya T, Uzu T, Maegawa H.
    Biochem Biophys Res Commun. 470(3) 539-545 2016年02月 [査読有り]
  • Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.
    Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T
    Sci Rep. 6 2016年01月 [査読有り]
  • 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.
    Tanaka Y, Kume S, Araki H, Nakazawa J, Chin-Kanasaki M, Araki S, Nakagawa F, Koya D, Haneda M, Maegawa H, Uzu T.
    Free Radic Biol Med. 89 831-841 2015年12月 [査読有り]
  • Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function.
    Araki S, Haneda M, Koya D, Kondo K, Tanaka S, Arima H, Kume S, Nakazawa J, Chin-Kanasaki M, Ugi S, Kawai H, Araki H, Uzu T, Maegawa
    Clin J Am Soc Nephrol 10(12) 2152-2158 2015年12月 [査読有り]
  • Emerging role of podocyte autophagy in the progression of diabetic nephropathy.
    Yasuda-Yamahara M, Kume S, Tagawa A, Maegawa H, Uzu T.
    Autophagy 11(12) 2385-2386 2015年11月 [査読有り]
  • Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis.
    Araki H, Ono S, Nishizawa Y, Deji N, Nakazawa J, Morita Y, Kume S, Chin-Kanasaki M, Isshiki K, Araki S, Arimura T, Maegawa H, Uzu T.
    Intern Med 54(17) 2217 2015年09月 [査読有り]
  • Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via enhancing energy expenditure.
    Yasuda-Yamahara M, Kume S, Yamahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Ugi S, Maegawa H, Uzu T.
    Biochem Biophys Res Commun. 465(2) 249-255 2015年09月 [査読有り]
  • Multiple osteoporotic fractures in a patient with CKD stage G3b.
    Uzu T, Araki S, Araki H, Kume S, Maegawa H.
    Kidney Int. 87(5) 1077 2015年05月 [査読有り]
  • Safety and efficacy of skin patches containing loxoprofen sodium in diabetic patients with overt nephropathy.
    ARAKI Hisazumi, KUWAGATA Shogo, SOUMURA Mariko, YAMAHARA Kosuke, MORITA Yoshikata, KUME Shinji, ISSHIKI Keiji, ARAKI Shin‐ichi, KASHIWAGI Atsunori, MAEGAWA Hiroshi, UZU Takashi
    Clin Exp Nephrol.  18(3) 487-491 2014年
  • Autophagy: emerging therapeutic target for diabetic nephropathy.
    Kume S., Yasuda M., Yamahara K., Koya D., Maegawa H.
    Semin Nephrol. 34(1) 9-16 2014年
  • Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.
    YASUDA Mako, TANAKA Yuki, KUME Shinji, MORITA Yoshikata, CHIN‐KANASAKI Masami, ARAKI Hisazumi, ISSHIKI Keiji, ARAKI Shin‐ichi, KOYA Daisuke, HANEDA Masakazu, KASHIWAGI Atsunori, MAEGAWA Hiroshi, UZU Takashi
    Biochim Biophys Acta. 1842(7) 1097-1108 2014年
  • Predictive properties of plasma amino acid profile for cardiovascular disease in patients with type 2 diabetes.
    Haneda M., Koya D., Kawai H., Ugi S., Uzu T., Kashiwagi A., Maegawa H., Kume S., Ono N., Araki S.-I., Muramatsu T., Shinhara A., Isshiki K., Araki H., Miyano H., Nakamura K.
    PLoS One.  9(6) 2014年
  • Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy.
    KUME Shinji, KOYA Daisuke, UZU Takashi, MAEGAWA Hiroshi
    Biomed Res Int. 2014(Pathology) 315494 2014年
  • Oral glucose-stimulated serum C-peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment.
    ARAKI Hisazumi, TANAKA Yuki, YOSHIDA Syohei, MORITA Yoshikata, KUME Shinji, ISSHIKI Keiji, ARAKI Shin-ichi, UZU Takashi, KASHIWAGI Atsunori, MAEGAWA Hiroshi
    J Diabetes Investig. 5(4) 435-441 2014年
  • Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage.
    TAKEDA Naoko, KUME Shinji, TANAKA Yuki, MORITA Yoshikata, CHIN‐KANASAKI Masami, ARAKI Hisazumi, ISSHIKI Keiji, ARAKI Shin‐Ichi, KASHIWAGI Atsunori, MAEGAWA Hiroshi, UZU Takashi, HANEDA Masakazu, KOYA Daisuke
    Am J Pathol. 183(3) 774-785 2013年
  • Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet.
    USHIO Masateru, NISHIO Yoshihiko, SEKINE Osamu, NAGAI Yoshio, MAENO Yasuhiro, UGI Satoshi, YOSHIZAKI Takeshi, MORINO Katsutaro, KUME Shinji, KASHIWAGI Atsunori, MAEGAWA Hiroshi
    Am J Physiol Endocrinol Metab.  305(1,Pt.1) 293-304 2013年
  • Cilostazol attenuates spontaneous microaggregation of platelets in type 2 diabetic patients with insufficient platelet response to aspirin.
    Kashiwagi A., Kawai H., Maegawa H., Uzu T., Araki S.-I., Haneda M., Matsuno H., Kanno Y., Koya D., Isshiki K., Kume S., Ugi S., Araki H.
    Diabetes Care.  36(7) 92-93 2013年
  • Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions.
    Matsusaka T., Haneda M., Maegawa H., Kashiwagi A., Uzu T., Yamahara K., Koya D., Kume S., Morita Y., Tanaka Y., Araki H., Chin-Kanasaki M., Araki S.-I., Isshiki K.
    J Am Soc Nephrol. 24(11) 1769-1781 2013年
  • The role of autophagy in the pathogenesis of diabetic nephropathy.
    Yamahara K., Kume S., Yasuda M., Maegawa H., Koya D., Uzu T.
    J Diabetes Res. 2013 2013年
  • High Sodium Intake is Associated With Masked Hypertension in Japanese Patients With Type 2 Diabetes and Treated Hypertension.
    Maegawa H., Uzu T., Kume S., Nakao K., Isshiki K., Araki H., Kawai H., Araki S.-I., Kashiwagi A., Ugi S.
    Am J Hypertens. 25(11) 1170-1174 2012年
  • Autophagy: a novel therapeutic target for kidney diseases.
    KUME Shinji, UZU Takashi, MAEGAWA Hiroshi, KOYA Daisuke
    Clin Exp Nephrol. 16(6) 827-832 2012年
  • Sirt1とカロリー制限
    Annual Review 腎臓 52-58 2011年
  • SIRT1, a Calorie Restriction Mimetic, in a New Therapeutic Approach for Type 2 Diabetes Mellitus and Diabetic Vascular Complications.
    Endocr Metab Immune Disord Drug Targets.  2010年
  • Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
    KUME Shinji, UZU Takashi, HORIIKE Kihachiro, CHIN‐KANASAKI Masami, ISSHIKI Keiji, ARAKI Shin‐ichi, SUGIMOTO Toshiro, HANEDA Masakazu, KASHIWAGI Atsunori, KOYA Daisuke
    J Clin Invest. 120(4) 1043-1055 2010年
  • Renoprotective effects of asialoerythropoietin in diabetic mice against ischaemia-reperfusion-induced acute kidney injury.
    UZU T, KASHIWAGI A, HANEDA M, KOYA D, SAKAGUCHI M, CHIN-KANASAKI M, YOKOMAKU Y, NAKAZAWA J, ISSHIKI K, SUGIMOTO T, ARAKI Si, KUME S
    Nephrology (Carlton).  15(1) 93-101 2010年
  • Association between urinary type IV collagen level and deterioration of renal function in type 2 diabetic patients without overt proteinuria.
    ARAKI Shin-Ichi, HANEDA Masakazu, KOYA Daisuke, ISSHIKI Keiji, KUME Shinji, SUGIMOTO Toshiro, KAWAI Hiromichi, NISHIO Yoshihiko, KASHIWAGI Atsunori, UZU Takashi, MAEGAWA Hiroshi
    Diabetes Care.  33(8) 1805-1810 2010年
  • Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell.
    SOUMURA Mariko, KUME Shinji, ISSHIKI Keiji, TAKEDA Naoko, ARAKI Shin-ichi, TANAKA Yuki, SUGIMOTO Toshiro, CHIN-KANASAKI Masami, NISHIO Yoshihiko, HANEDA Masakazu, KOYA Daisuke, KASHIWAGI Atsunori, MAEGAWA Hiroshi, UZU Takashi
    Biochem Biophys Res Commun. 402(2) 265-271 2010年
  • Effects of blood pressure and the renin-angiotensin system on platelet activation in type 2 diabetes
    KASHIWAGI A, MAEGAWA H, SUGIOMOTO T, ARAKI S, ISSHIKI K, KANASAKI M, KUME S, YOKOMAKU Y, KADOTA A, TSUDA A, SAKAGUCHI M, UZU T
    Journal of Diabetes Investigation  1(5) 196-201 2010年
  • Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway.
    KITADA Munehiro, KUME Shinji, IMAIZUMI Noriko, KOYA Daisuke
    Diabetes. 60(2) 634-643 2010年
  • Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model.
    HIRATA Kunio, KUME Shinji, ARAKI Shin-ichi, SAKAGUCHI Masayoshi, CHIN-KANASAKI Masami, ISSHIKI Keiji, SUGIMOTO Toshiro, NISHIYAMA Akira, KOYA Daisuke, HANEDA Masakazu, KASHIWAGI Atsunori, UZU Takashi
    Biochem Biophys Res Commun.  380(1) 44-49 2009年
  • Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker.
    UZU Takashi, SAKAGUCHI Masayoshi, YOKOMAKU Yukiyo, KUME Shinji, KANASAKI Masami, ISSHIKI Keiji, ARAKI Shin‐ichi, SUGIOMOTO Toshiro, KOYA Daisuke, HANEDA Masakazu, KASHIWAGI Atsunori
    Clin Exp Nephrol.  13(4) 300-306 2009年
  • Peroxisome proliferator-activated receptors in diabetic nephropathy.
    PPAR Res.  2008(ID 879523) 2009年
  • SIRT1 and insulin resistance.
    KOYA D, KUME S, LIANG Fx
    Nat Rev Endocrinol. 5(7) 367-373 2009年
  • Asialoerythropoietin prevents contrast-induced nephropathy.
    KASHIWAGI A, UZU T, KOYA D, HANEDA M, NITTA N, SAKAGUCHI M, CHIN-KANASAKI M, ISSHIKI K, ARAKI Si, KUME S, SUGIMOTO T, YOKOMAKU Y
    J Am Soc Nephrol. 19(2) 321-328 2008年
  • IS TUBULOINTERSTITIAL NEPHRITIS AND UVEITIS SYNDROME ASSOCIATED WITH IgG4-RELATED SYSTEMIC DISEASE?
    KASHIWAGI A, UZU T, KUME S, MORITA Y, TANAKA Y, SUGIMOTO T
    Nephrology (Carlton).  13(1) 89 2008年
  • Structural and functional changes in the kidneys of high-fat diet-induced obese mice.
    DEJI Naoko, KUME Shinji, ARAKI Shin‐ichi, SOUMURA Mariko, SUGIMOTO Toshiro, ISSHIKI Keiji, CHIN‐KANASAKI Masami, SAKAGUCHI Masayoshi, KOYA Daisuke, HANEDA Masakazu, KASHIWAGI Atsunori, UZU Takashi
    Am J Physiol Renal Physiol 296(1,Pt.2) 118-126 2008年
  • Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet.
    KUME S, UZU T, ARAKI Si, SUGIMOTO T, ISSHIKI K, CHIN-KANASAKI M, SAKAGUCHI M, KUBOTA N, TERAUCHI Y, KADOWAKI T, HANEDA M, KASHIWAGI A, KOYA D
    J Am Soc Nephrol.  18(10) 2715-2723 2007年
  • 重症筋無力症に合併した難治性バセドウ眼症の1例
    臨床神経学 46(4) 266-269 2006年
  • Improvement of renal lipid metabolism in the heterozygous PPARγdeficient mice attenuates high fat diet-induced renal injuries.
    The 8th Insulin Action Symposium 2006年
  • Silent information regulator2(SIRT1)attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.
    KUME S, HANEDA M, KANASAKI K, SUGIMOTO T, ARAKI Si, ISONO M, ISSHIKI K, UZU T, KASHIWAGI A, KOYA D
    freeradbiomed. 40(12) 2175-2182 2006年
  • SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.
    KUME Shinji, HANEDA Masakazu, KANASAKI Keizo, SUGIMOTO Toshiro, ARAKI Shin‐ichi, ISSHIKI Keiji, ISONO Motohide, UZU Takashi, GUARENTE Leonard, KASHIWAGI Atsunori, KOYA Daisuke, KOYA Daisuke
    J Biol Chem.  282(1) 151-158 2006年
  • Pulmonary-renal syndrome, diffuse pulmonary hemorrhage and glomerulonephritis, associated with Wegener's granulomatosis effectively treated with early plasma exchange therapy.
    SUGIMOTO Toshiro, DEJI Naoko, KUME Shinji, OSAWA Norihisa, SAKAGUCHI Masayoshi, ISSHIKI Keiji, KOYA Daisuke, KASHIWAGI Atsunori
    Intern Med.  46(1) 49-53 2006年
  • Familial pseudohyperkalemia: a rare cause of hyperkalemia
    SUGIMOTO Toshiro, KUME Shinji, OSAWA Norihisa, NAKAZAWA Jun, KOYA Daisuke, KASHIWAGI Atsunori
    Intern Med 44(8) 875-878 2005年

MISC

  • 老化に伴う腎尿細管障害におけるSirt1 - オートファジー経路の役割
    基礎老化研究 35(1) 9-15 2011年
  • 慢性血液透析患者におけるシナカルセトのJSDTガイドライン達成率への影響-びわこ臨床透析カンファレンス共同研究-
    有村徹朗, 磯野元秀, 大橋誠治, 近藤守寛, 鹿野勉, 富田耕彬, 西尾利二, 西村正孝, 八田告, 西尾利樹, 永作大輔, 久米真司, 一色啓二, 宇津貴
    透析会誌 43(9) 787-794 2010年
  • 摘出腫瘤の病理組織標本所見より頚椎腫瘍状石灰沈着症(cervical tumoral calcinosis)と診断し得た維持透析患者の1例
    一色啓二, 一色啓二, 中澤純, 杉本俊郎, 坂口正芳, 小山哲朗, 田中敬, 武田尚子, 田中裕紀, 安田真子, 津田安都子, 久米真司, 金崎雅美, 金崎雅美, 荒木信一, 川添智道, 時田由美子, 中村紘子, 前田憲吾, 富田耕彬, 宇津貴, 宇津貴, 高橋忍, 岡田裕作
    透析会誌 41(8) 483-488 2008年
  • 腎症ー発症機序 高脂肪食誘発肥満モデルマウスにおける腎病変発症と腎脂質代謝異常の検討
    第21回日本糖尿病合併症学会プログラム・抄録集 21-21 2006年
  • 腎症 Nephropathy-1PPARrヘテロ欠損マウスを用いた糖・脂肪代謝異常に伴う腎病変発症機構の検討
    第49回日本糖尿病学会雑誌 103-103 2006年
  • 抗老化遺伝子SIRT1はメザンギウム細胞においてTGFβ誘発アポトーシスを抑制する
    第49回日本腎臓学会雑誌 P-155-P-155 2006年
  • Contribution of Altered Renal Lipid Metabolism to High Fat Diet-Induced Renal Injury.
    66th Scientific Sessions-ADA Annual Meeting 768-P-768-P 2006年
  • 著明な脾腫、汎血球減少、肝線維症を伴った常染色体優性遺伝多発性嚢胞腎の1例
    日本腎臓学会誌 463-467 2005年
  • 1型糖尿病患者における微量アルブミン尿の消退
    Diabetes Ftontier 15.1 109-110 2004年
  • 1型糖尿病性腎症の発症・進展に対する強化療法の持続的効果 -EDIC研究より-
    Diabetes Frontier 15.3 406-407 2004年