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縣 保年

所属部署名生化学・分子生物学講座(分子生理化学)
職名教授
 
 
更新日: 17/11/17 09:54

研究者基本情報

氏名

    縣 保年

所属(マスタ)

  • 生化学・分子生物学講座(分子生理化学) 教授

学歴

  • - 1994年京都大学 医学研究科 生理系
  • - 1990年金沢大学 医学部 医学科

学位

  • 医学博士(京都大学)

所属学協会

    日本生化学会 , 日本分子生物学会

経歴

  • 京都大学 大学院医学研究科(助手)

研究活動情報

研究分野

  • 基礎医学 / 医化学一般

研究キーワード

    転写制御

論文

  • Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program.
    Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H
    Genes & development 30(22) 2475-2485 2016年11月 [査読有り]
  • The Effect of D-Aspartate on Spermatogenesis in Mouse Testis.
    Tomita K, Tanaka H, Kageyama S, Nagasawa M, Wada A, Murai R, Kobayashi K, Hanada E, Agata Y, Kawauchi A
    Biology of reproduction 94(2) 30 2016年02月 [査読有り]
  • Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells.
    Tomokatsu I, Masuda K, Huijskens MJ, Satoh R, Kakugawa K, Agata Y, Miyai T, Germeraad WT, Katsura Y, Kawamoto H
    Stem cell reports 5(5) 716-727 2015年11月 [査読有り]
  • The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
    Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, Rodewald HR, Saito R, Chang AN, Varki N, Kawamoto H, Murre C
    Genes & development 29(4) 409-425 2015年02月 [査読有り]
  • Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia.
    Doi K, Imai T, Kressler C, Yagita H, Agata Y, Vooijs M, Hamazaki Y, Inoue J, Minato N
    Scientific reports 5 7978 2015年01月 [査読有り]
  • Immunohistochemical localization of D-serine dehydratase in chicken tissues.
    Nishimura Y, Tanaka H, Ishida T, Imai S, Matsusue Y, Agata Y, Horiike K
    Acta histochemica 116(5) 702-707 2014年06月 [査読有り]
  • Reciprocal control of G1-phase progression is required for Th-POK/Runx3-mediated CD4/8 thymocyte cell fate decision.
    Sato T, Chiba T, Ohno S, Sato C, Sugoh T, Miyashita K, Akatsuka H, Hozumi K, Okada Y, Iida Y, Akatsuka A, Agata Y, Chiba M, Kohu K, Satake M, Tanabe H, Saya H, Habu S
    Journal of immunology (Baltimore, Md. : 1950) 189(9) 4426-4436 2012年11月 [査読有り]
  • E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.
    Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ, Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, Agata Y
    Journal of immunology (Baltimore, Md. : 1950) 188(11) 5547-5560 2012年06月 [査読有り]
  • Imatinib mesylate directly impairs class switch recombination through down-regulation of AID: its potential efficacy as an AID suppressor.
    Kawamata T, Lu J, Sato T, Tanaka M, Nagaoka H, Agata Y, Toyoshima T, Yokoyama K, Oyaizu N, Nakamura N, Ando K, Tojo A, Kotani A
    Blood 119(13) 3123-3127 2012年03月 [査読有り]
  • High expression of nuclear factor 90 (NF90) leads to mitochondrial degradation in skeletal and cardiac muscles.
    Higuchi T, Sakamoto S, Kakinuma Y, Kai S, Yagyu K, Todaka H, Chi E, Okada S, Ujihara T, Morisawa K, Ono M, Sugiyama Y, Ishida W, Fukushima A, Tsuda M, Agata Y, Taniguchi T
    PloS one 7(8) e43340 2012年 [査読有り]
  • The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.
    Miyazaki M, Rivera RR, Miyazaki K, Lin YC, Agata Y, Murre C
    Nature immunology 12(10) 992-1001 2011年08月 [査読有り]
  • Regulation of TCR Vγ2 gene rearrangement by the helix-loop-helix protein, E2A.
    Nozaki M, Wakae K, Tamaki N, Sakamoto S, Ohnishi K, Uejima T, Minato N, Yanagihara I, Agata Y
    International immunology 23(5) 297-305 2011年05月 [査読有り]
  • Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency.
    Kawai Y, Hamazaki Y, Fujita H, Fujita A, Sato T, Furuse M, Fujimoto T, Jetten AM, Agata Y, Minato N
    Proceedings of the National Academy of Sciences of the United States of America 108(10) 4075-4080 2011年03月 [査読有り]
  • The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway.
    Sakamoto S, Aoki K, Higuchi T, Todaka H, Morisawa K, Tamaki N, Hatano E, Fukushima A, Taniguchi T, Agata Y
    Molecular and cellular biology 29(13) 3754-3769 2009年07月 [査読有り]
  • Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion.
    Kitao H, Kimura M, Yamamoto K, Seo H, Namikoshi K, Agata Y, Ohta K, Takata M
    International immunology 20(2) 277-284 2008年02月 [査読有り]
  • Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.
    Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C
    Immunity 27(6) 871-884 2007年12月 [査読有り]
  • Spontaneous large-scale lymphoid neogenesis and balanced autoimmunity versus tolerance in the stomach of H+/K+-ATPase-reactive TCR transgenic mouse.
    Katakai T, Nomura T, Gonda H, Sugai M, Agata Y, Nishio A, Masuda T, Sakaguchi S, Shimizu A
    Journal of immunology (Baltimore, Md. : 1950) 177(11) 7858-7867 2006年12月 [査読有り]
  • [Chromatin dynamics in gene rearrangement].
    Agata Y
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51(4) 315-325 2006年04月 [査読有り]
  • Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription.
    Murai K, Naruse Y, Shaul Y, Agata Y, Mori N
    Nucleic acids research 32(10) 3180-3189 2004年 [査読有り]
  • Transcription-coupled events associating with immunoglobulin switch region chromatin.
    Nambu Y, Sugai M, Gonda H, Lee CG, Katakai T, Agata Y, Yokota Y, Shimizu A
    Science (New York, N.Y.) 302(5653) 2137-2140 2003年12月 [査読有り]
  • The balance between Pax5 and Id2 activities is the key to AID gene expression.
    Gonda H, Sugai M, Nambu Y, Katakai T, Agata Y, Mori KJ, Yokota Y, Shimizu A
    The Journal of experimental medicine 198(9) 1427-1437 2003年11月 [査読有り]
  • E-proteins directly regulate expression of activation-induced deaminase in mature B cells.
    Sayegh CE, Quong MW, Agata Y, Murre C
    Nature immunology 4(6) 586-593 2003年06月 [査読有り]
  • Chemokine-independent preference for T-helper-1 cells in transendothelial migration.
    Katakai T, Hara T, Sugai M, Gonda H, Nambu Y, Matsuda E, Agata Y, Shimizu A
    The Journal of biological chemistry 277(52) 50948-50958 2002年12月 [査読有り]

競争的資金

  • Znフィンガー転写因子の転写抑制機構の解析
  • Znフィンガー因子の遺伝子単離