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礒野 高敬

所属部署名実験実習支援センター
職名准教授
 
 
更新日: 17/11/20 09:40

研究者基本情報

氏名

    礒野 高敬

所属(マスタ)

  • 実験実習支援センター 准教授

学歴

  • - 1982年京都大学 理学研究科 植物学
  • - 1977年京都大学 理学部

学位

  • 理学博士(京都大学)

所属学協会

    日本癌学会 , 日本分子生物学会

経歴

  • 1995年- 現在滋賀医科大学(准教授)
  • 1985年- 1995年 滋賀医科大学 助手

研究活動情報

研究キーワード

    腫瘍診断学

論文

  • Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas.
    Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Suzaki M, Yuasa T
    American journal of cancer research 6(10) 2263-2276 2016年10月 [査読有り]
  • Therapeutic inhibition of mitochondrial function induces cell death in starvation-resistant renal cell carcinomas.
    Isono T, Chano T, Yonese J, Yuasa T
    Scientific reports 6 25669 2016年05月 [査読有り]
  • Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report.
    Fujiwara R, Kageyama S, Tomita K, Hanada E, Tsuru T, Yoshida T, Narita M, Isono T, Kawauchi A
    Case reports in oncology 8(2) 339-344 2015年08月 [査読有り]
  • Proteome research in urothelial carcinoma.
    Kageyama S, Isono T, Iwaki H, Hanada E, Tomita K, Yoshida T, Yoshiki T, Kawauchi A
    International journal of urology : official journal of the Japanese Urological Association 22(7) 621-628 2015年07月 [査読有り]
  • Analysis of new biomarkers for cholangiocarcinoma.
    Miwa M, You G, Tanaka H, Taniguchi S, Fujii T, Kamemura K, Suzaki M, Isono T, Tooyama I, Tanaka M, Srivatanakul P, Viwatthanasittiphong C, Sangrajrang S, Khuhaprema T
    Journal of hepato-biliary-pancreatic sciences 21(6) 397-398 2014年06月 [査読有り]
  • Suppression of cerebral aneurysm formation in rats by a tumor necrosis factor-α inhibitor.
    Yokoi T, Isono T, Saitoh M, Yoshimura Y, Nozaki K
    Journal of neurosurgery 120(5) 1193-1200 2014年05月 [査読有り]
  • Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells.
    Isono T, Chano T, Kitamura A, Yuasa T
    PloS one 9(5) e96168 2014年05月 [査読有り]
  • Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.
    Kim CJ, Tambe Y, Mukaisho K, Sugihara H, Isono T, Sonoda H, Shimizu T, Kondoh G, Inoue H
    Carcinogenesis 35(1) 227-236 2014年01月 [査読有り]
  • Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation.
    Isono T, Chano T, Okabe H, Suzaki M
    PloS one 8(4) e60397 2013年 [査読有り]
  • A global transcriptome analysis of a dog model of congestive heart failure with the human genome as a reference.
    Isono T, Matsumoto T, Wada A, Suzaki M, Chano T
    Journal of cardiac failure 18(11) 872-878 2012年11月 [査読有り]
  • PKC-Mediated ZYG1 Phosphorylation Induces Fusion of Myoblasts as well as of Dictyostelium Cells.
    Amagai A, Macwilliams H, Isono T, Omatsu-Kanbe M, Urano S, Yamamoto K, Maeda Y
    International journal of cell biology 2012 657423 2012年 [査読有り]
  • RB1CC1 activates the p16 promoter through the interaction with hSNF5.
    Ochi Y, Chano T, Ikebuchi K, Inoue H, Isono T, Arai A, Tameno H, Shimada T, Hisa Y, Okabe H
    Oncology reports 26(4) 805-812 2011年10月 [査読有り]
  • O-GlcNAc-specific antibody CTD110.6 cross-reacts with N-GlcNAc2-modified proteins induced under glucose deprivation.
    Isono T
    PloS one 6(4) e18959 2011年04月 [査読有り]
  • RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients.
    Chano T, Ikebuchi K, Tomita Y, Jin Y, Inaji H, Ishitobi M, Teramoto K, Ochi Y, Tameno H, Nishimura I, Minami K, Inoue H, Isono T, Saitoh M, Shimada T, Hisa Y, Okabe H
    PloS one 5(12) e15737 2010年12月 [査読有り]
  • Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes.
    Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H
    The Journal of membrane biology 235(2) 73-87 2010年06月 [査読有り]
  • RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer.
    Chano T, Ikebuchi K, Ochi Y, Tameno H, Tomita Y, Jin Y, Inaji H, Ishitobi M, Teramoto K, Nishimura I, Minami K, Inoue H, Isono T, Saitoh M, Shimada T, Hisa Y, Okabe H
    PloS one 5(6) e11404 2010年06月 [査読有り]
  • Cyclin D1b variant promotes cell invasiveness independent of binding to CDK4 in human bladder cancer cells.
    Kim CJ, Nishi K, Isono T, Okuyama Y, Tambe Y, Okada Y, Inoue H
    Molecular carcinogenesis 48(10) 953-964 2009年10月 [査読有り]
  • The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
    Tambe Y, Yamamoto A, Isono T, Chano T, Fukuda M, Inoue H
    Cancer letters 283(1) 74-83 2009年09月 [査読有り]
  • Suppression of cell invasiveness by periostin via TAB1/TAK1.
    Isono T, Kim CJ, Ando Y, Sakurai H, Okada Y, Inoue H
    International journal of oncology 35(2) 425-432 2009年08月 [査読有り]
  • Urinary calreticulin in the diagnosis of bladder urothelial carcinoma.
    Kageyama S, Isono T, Matsuda S, Ushio Y, Satomura S, Terai A, Arai Y, Kawakita M, Okada Y, Yoshiki T
    International journal of urology : official journal of the Japanese Urological Association 16(5) 481-486 2009年05月 [査読有り]
  • Role of alternative splicing of periostin in human bladder carcinogenesis.
    Kim CJ, Isono T, Tambe Y, Chano T, Okabe H, Okada Y, Inoue H
    International journal of oncology 32(1) 161-169 2008年01月 [査読有り]
  • Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.
    Minami K, Tambe Y, Watanabe R, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, Okabe H, Chano T, Inoue H
    Journal of virology 81(20) 11106-11115 2007年10月 [査読有り]
  • Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux.
    Iwaki H, Johnin K, Kageyama S, Kim CJ, Isono T, Yoshiki T
    International journal of urology : official journal of the Japanese Urological Association 14(10) 918-923 2007年10月 [査読有り]
  • Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
    Tambe Y, Yoshioka-Yamashita A, Mukaisho K, Haraguchi S, Chano T, Isono T, Kawai T, Suzuki Y, Kushima R, Hattori T, Goto M, Yamada S, Kiso M, Saga Y, Inoue H
    Carcinogenesis 28(4) 777-784 2007年04月 [査読有り]
  • GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress.
    Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, Okabe H, Chano T
    International journal of molecular medicine 19(3) 475-483 2007年03月 [査読有り]
  • A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.
    Kageyama S, Iwaki H, Inoue H, Isono T, Yuasa T, Nogawa M, Maekawa T, Ueda M, Kajita Y, Ogawa O, Toguchida J, Yoshiki T
    Proteomics. Clinical applications 1(2) 192-199 2007年02月 [査読有り]
  • Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes.
    Zankov DP, Omatsu-Kanbe M, Isono T, Toyoda F, Ding WG, Matsuura H, Horie M
    Circulation 113(10) 1278-1286 2006年03月 [査読有り]
  • Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure.
    Dohke T, Wada A, Isono T, Fujii M, Yamamoto T, Tsutamoto T, Horie M
    Journal of cardiac failure 12(1) 77-84 2006年02月 [査読有り]
  • Effect of ATP on preadipocyte migration and adipocyte differentiation by activating P2Y receptors in 3T3-L1 cells.
    Omatsu-Kanbe M, Inoue K, Fujii Y, Yamamoto T, Isono T, Fujita N, Matsuura H
    The Biochemical journal 393(Pt 1) 171-180 2006年01月 [査読有り]
  • Rb1cc1 is critical for myoblast differentiation through Rb1 regulation.
    Watanabe R, Chano T, Inoue H, Isono T, Koiwai O, Okabe H
    Virchows Archiv : an international journal of pathology 447(3) 643-648 2005年09月 [査読有り]
  • Pathogenic potentials of glycoprotein C-negative syncytial mutants from rabbit T cells infected persistently with herpes simplex virus type 1.
    Ishida Y, Okabe T, Azukizawa Y, Isono T, Seto A
    Journal of medical virology 76(1) 89-97 2005年05月 [査読有り]
  • Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis.
    Iwaki H, Kageyama S, Isono T, Wakabayashi Y, Okada Y, Yoshimura K, Terai A, Arai Y, Iwamura H, Kawakita M, Yoshiki T
    Cancer science 95(12) 955-961 2004年12月 [査読有り]
  • Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor.
    Takayama T, Wada A, Tsutamoto T, Ohnishi M, Fujii M, Isono T, Horie M
    Circulation journal : official journal of the Japanese Circulation Society 68(11) 1067-1075 2004年11月 [査読有り]
  • Endogenous bradykinin suppresses myocardial fibrosis through the cardiac-generated endothelin system under chronic angiotensin-converting enzyme inhibition in heart failure.
    Fujii M, Wada A, Ohnishi M, Tsutamoto T, Matsumoto T, Yamamoto T, Takayama T, Dohke T, Isono T, Eguchi Y, Horie M
    Journal of cardiovascular pharmacology 44 Suppl 1 S346-9 2004年11月 [査読有り]
  • Actin filaments play a permissive role in the inhibition of store-operated Ca2+ entry by extracellular ATP in rat brown adipocytes.
    Omatsu-Kanbe M, Shibata M, Yamamoto T, Isono T, Matsuura H
    The Biochemical journal 381(Pt 2) 389-396 2004年07月 [査読有り]
  • Identification by proteomic analysis of calreticulin as a marker for bladder cancer and evaluation of the diagnostic accuracy of its detection in urine.
    Kageyama S, Isono T, Iwaki H, Wakabayashi Y, Okada Y, Kontani K, Yoshimura K, Terai A, Arai Y, Yoshiki T
    Clinical chemistry 50(5) 857-866 2004年05月 [査読有り]
  • A novel apoptotic pathway induced by the drs tumor suppressor gene.
    Tambe Y, Isono T, Haraguchi S, Yoshioka-Yamashita A, Yutsudo M, Inoue H
    Oncogene 23(17) 2977-2987 2004年04月 [査読有り]
  • Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure.
    Matsumoto T, Wada A, Tsutamoto T, Ohnishi M, Isono T, Kinoshita M
    Circulation 107(20) 2555-2558 2003年05月 [査読有り]
  • Mutation screening of the human period 2 gene in bipolar disorder.
    Shiino Y, Nakajima S, Ozeki Y, Isono T, Yamada N
    Neuroscience letters 338(1) 82-84 2003年02月 [査読有り]
  • Developmental expression of glial cell-line derived neurotrophic factor, neurturin, and their receptor mRNA in the rat urinary bladder.
    Kawakami T, Wakabayashi Y, Aimi Y, Isono T, Okada Y
    Neurourology and urodynamics 22(1) 83-88 2003年 [査読有り]
  • Molecular cloning and expression of uroplakins in transitional cell carcinoma.
    Yuasa T, Yoshiki T, Isono T, Tanaka T, Okada Y
    Advances in experimental medicine and biology 539(Pt A) 33-46 2003年 [査読有り]
  • Structural diversity of cancer-related and non-cancer-related prostate-specific antigen.
    Isono T, Tanaka T, Kageyama S, Yoshiki T
    Clinical chemistry 48(12) 2187-2194 2002年12月 [査読有り]
  • Multiple P2 receptors contribute to a transient increase in intracellular Ca2+ concentration in ATP-stimulated rat brown adipocytes.
    Omatsu-Kanbe M, Isono T, Matsuura H
    Experimental physiology 87(6) 643-652 2002年11月 [査読有り]
  • Expression of neurotrophin messenger RNAs during rat urinary bladder development.
    Kawakami T, Wakabayashi Y, Isono T, Aimi Y, Okada Y
    Neuroscience letters 329(1) 77-80 2002年08月 [査読有り]
  • Rapidly and slowly activating components of delayed rectifier K(+) current in guinea-pig sino-atrial node pacemaker cells.
    Matsuura H, Ehara T, Ding WG, Omatsu-Kanbe M, Isono T
    The Journal of physiology 540(Pt 3) 815-830 2002年05月 [査読有り]
  • Bradykinin improves left ventricular diastolic function under long-term angiotensin-converting enzyme inhibition in heart failure.
    Fujii M, Wada A, Tsutamoto T, Ohnishi M, Isono T, Kinoshita M
    Hypertension (Dallas, Tex. : 1979) 39(5) 952-957 2002年05月 [査読有り]
  • High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma.
    Kageyama S, Yoshiki T, Isono T, Tanaka T, Kim CJ, Yuasa T, Okada Y
    Japanese journal of cancer research : Gann 93(5) 523-531 2002年05月 [査読有り]