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清水 猛史

所属部署名耳鼻咽喉科学講座
職名教授
 
 
更新日: 17/11/17 09:59

研究者基本情報

氏名

    清水 猛史

所属(マスタ)

  • 耳鼻咽喉科学講座 教授

学歴

  • 1983年04月- 1987年03月三重大学医学部 大学院博士課程 耳鼻咽喉科
  • 1977年04月- 1983年03月三重大学 医学部

学位

  • 医学博士1987年(三重大学)

所属学協会

    日本小児耳鼻咽喉科学会 , American Thoracic Society , Association for Research in Otolaryngology , 日本めまい平衡医学会 , 日本聴覚医学会 , 日本嚥下医学会 , 日本喉頭科学会 , 日本耳鼻咽喉科感染症・エアロゾル学会 , 日本口腔・咽頭科学会 , 日本耳鼻咽喉科免疫アレルギー学会 , 日本耳科学会 , 日本頭頸部外科学会 , 日本頭頸部癌学会 , 日本鼻科学会 , 日本耳鼻咽喉科臨床学会 , 日本気管食道科学会 , 日本アレルギー学会 , 日本耳鼻咽喉科学会

経歴

  • 2004年02月- 現在滋賀医科大学(教授)
  • 2001年10月- 2004年02月三重大学医学部(助教授)
  • 1996年12月- 2001年09月三重大学医学部(講師)
  • 1991年04月- 1996年11月三重大学医学部(助手)
  • 1988年09月- 1991年03月米国環境衛生科学研究所(Visiting Associate)

研究活動情報

論文

  • Comparison between chemoselection and definitive radiotherapy in patients with cervical esophageal squamous cell carcinoma.
    Nakata Y, Hanai N, Nishikawa D, Suzuki H, Koide Y, Fukuda Y, Nomura M, Kodaira T, Shimizu T, Hasegawa Y
    International journal of clinical oncology 2017年06月 [査読有り]
  • Severely infected pneumoceles of the frontal sinus in patients with mental retardation and brain atrophy treated by endoscopic sinus surgery.
    Tojima I, Kikuoka H, Ogawa T, Shimizu T
    Auris, nasus, larynx 2017年05月 [査読有り]
  • The effect of calprotectin on TSLP and IL-25 production from airway epithelial cells.
    Kato T, Kouzaki H, Matsumoto K, Hosoi J, Shimizu T
    Allergology international : official journal of the Japanese Society of Allergology 66(2) 281-289 2017年04月 [査読有り]
  • Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia.
    Ogawa T, Irikawa N, Yanagisawa D, Shiino A, Tooyama I, Shimizu T
    Auris, nasus, larynx 44(2) 168-173 2017年04月 [査読有り]
  • Endogenous Protease Inhibitors in Airway Epithelial Cells Contribute to Eosinophilic Chronic Rhinosinusitis.
    Kouzaki H, Matsumoto K, Kikuoka H, Kato T, Tojima I, Shimizu S, Kita H, Shimizu T
    American journal of respiratory and critical care medicine 195(6) 737-747 2017年03月 [査読有り]
  • Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study.
    Nakata Y, Ijichi K, Hanai N, Nishikawa D, Suzuki H, Hirakawa H, Kodaira T, Fujimoto Y, Fujii T, Miyazaki T, Shimizu T, Hasegawa Y
    Auris, nasus, larynx 44(1) 104-110 2017年02月 [査読有り]
  • Thrombin and activated coagulation factor X stimulate the release of cytokines and fibronectin from nasal polyp fibroblasts via protease-activated receptors.
    Shimizu S, Tojima I, Takezawa K, Matsumoto K, Kouzaki H, Shimizu T
    American journal of rhinology & allergy 31(1) 13-18 2017年01月 [査読有り]
  • Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice.
    Iwasaki N, Matsushita K, Fukuoka A, Nakahira M, Matsumoto M, Akasaki S, Yasuda K, Shimizu T, Yoshimoto T
    The Journal of allergy and clinical immunology 139(1) 258-268.e10 2017年01月 [査読有り]
  • Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis.
    Tojima I, Kouzaki H, Shimizu S, Ogawa T, Arikata M, Kita H, Shimizu T
    Clinical immunology (Orlando, Fla.) 170 1-8 2016年09月 [査読有り]
  • HMGB1-TLR4 signaling contributes to the secretion of interleukin 6 and interleukin 8 by nasal epithelial cells.
    Shimizu S, Kouzaki H, Kato T, Tojima I, Shimizu T
    American journal of rhinology & allergy 30(3) 167-172 2016年05月 [査読有り]
  • Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan.
    Shimizu T, Suzaki H
    Auris, nasus, larynx 43(2) 131-136 2016年04月 [査読有り]
  • Epithelial Cell-Derived Cytokines Contribute to the Pathophysiology of Eosinophilic Chronic Rhinosinusitis.
    Kouzaki H, Matsumoto K, Kato T, Tojima I, Shimizu S, Shimizu T
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 36(3) 169-179 2016年03月 [査読有り]
  • Epidermal growth factor receptor inhibitor AG1478 inhibits mucus hypersecretion in airway epithelium.
    Takezawa K, Ogawa T, Shimizu S, Shimizu T
    American journal of rhinology & allergy 30(1) 1-6 2016年01月 [査読有り]
  • Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium.
    Tojima I, Shimizu S, Ogawa T, Kouzaki H, Omura S, Sunazuka T, Shimizu T
    Auris, nasus, larynx 42(4) 332-336 2015年08月 [査読有り]
  • Tissue factor and tissue factor pathway inhibitor in nasal mucosa and nasal secretions of chronic rhinosinusitis with nasal polyp.
    Shimizu S, Ogawa T, Takezawa K, Tojima I, Kouzaki H, Shimizu T
    American journal of rhinology & allergy 29(4) 235-242 2015年07月 [査読有り]
  • Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16(INK4a) in sinonasal diseases.
    Yamashita Y, Hasegawa M, Deng Z, Maeda H, Kondo S, Kyuna A, Matayoshi S, Agena S, Uehara T, Kouzaki H, Shimizu T, Ikegami T, Ganaha A, Suzuki M
    Infectious agents and cancer 10 23 2015年 [査読有り]
  • Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling.
    Shimizu S, Kouzaki H, Ogawa T, Takezawa K, Tojima I, Shimizu T
    American journal of rhinology & allergy 28(2) 103-109 2014年03月 [査読有り]
  • Valproic acid promotes neural regeneration of olfactory epithelium in adult mice after methimazole-induced damage.
    Ogawa T, Takezawa K, Shimizu S, Shimizu T
    American journal of rhinology & allergy 28(2) e95-9 2014年03月 [査読有り]
  • Pro-resolution mediator lipoxin A4 and its receptor in upper airway inflammation.
    Shimizu S, Ogawa T, Seno S, Kouzaki H, Shimizu T
    The Annals of otology, rhinology, and laryngology 122(11) 683-689 2013年11月 [査読有り]
  • Transcription of interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells.
    Kouzaki H, Tojima I, Kita H, Shimizu T
    American journal of respiratory cell and molecular biology 49(5) 741-750 2013年11月 [査読有り]
  • Distinct localization of peripheral and central types of choline acetyltransferase in the rat cochlea.
    Kitanishi T, Aimi Y, Kitano H, Suzuki M, Kimura H, Saito A, Shimizu T, Tooyama I
    Acta histochemica et cytochemica 46(5) 145-152 2013年10月 [査読有り]
  • The effect of heparin on antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.
    Ogawa T, Shimizu S, Shimizu T
    Allergology international : official journal of the Japanese Society of Allergology 62(1) 77-83 2013年03月 [査読有り]
  • Expression and localization of aquaporin 1, 2, 3, 4, and 5 in human nasal mucosa.
    Seno S, Ogawa T, Shibayama M, Kouzaki H, Shimizu T
    American journal of rhinology & allergy 26(3) 167-171 2012年05月 [査読有り]
  • Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin.
    Ogawa T, Takezawa K, Tojima I, Shibayama M, Kouzaki H, Ishida M, Okabe H, Shimizu T
    Auris, nasus, larynx 39(2) 224-228 2012年04月 [査読有り]
  • A new modification of uvulopalatopharyngoplasty for the treatment of obstructive sleep apnea syndrome.
    Komada I, Miyazaki S, Okawa M, Nishikawa M, Shimizu T
    Auris, nasus, larynx 39(1) 84-89 2012年02月 [査読有り]
  • Azithromycin inhibits mucus hypersecretion from airway epithelial cells.
    Shimizu T, Shimizu S
    Mediators of inflammation 2012 265714 2012年 [査読有り]
  • Heparin inhibits mucus hypersecretion in airway epithelial cells.
    Ogawa T, Shimizu S, Tojima I, Kouzaki H, Shimizu T
    American journal of rhinology & allergy 25(2) 69-74 2011年03月 [査読有り]
  • Role of thrombin in chronic rhinosinusitis-associated tissue remodeling.
    Shimizu S, Gabazza EC, Ogawa T, Tojima I, Hoshi E, Kouzaki H, Shimizu T
    American journal of rhinology & allergy 25(1) 7-11 2011年01月 [査読有り]
  • Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea.
    Kitano M, Ishinaga H, Shimizu T, Takeuchi K, Majima Y
    Pharmacology 87(1-2) 56-62 2011年 [査読有り]
  • True aneurysm of the facial artery.
    Hoshi E, Owaki S, Ogawa F, Fukui J, Ogawa T, Shimizu T
    Auris, nasus, larynx 37(5) 656-658 2010年10月 [査読有り]
  • Effect of nitric oxide synthase inhibitor on increase in nasal mucosal blood flow induced by sensory and parasympathetic nerve stimulation in rats.
    Ogawa F, Hanamitsu M, Ayajiki K, Aimi Y, Okamura T, Shimizu T
    The Annals of otology, rhinology, and laryngology 119(6) 424-430 2010年06月 [査読有り]
  • Relationship between transglottal pressure and fundamental frequency of phonation--study using a rubber model.
    Owaki S, Kataoka H, Shimizu T
    Journal of voice : official journal of the Voice Foundation 24(2) 127-132 2010年03月 [査読有り]
  • Endoscopic sinus surgery for the odontogenic maxillary cysts.
    Seno S, Ogawal T, Shibayama M, Ogawa F, Fukui J, Owaki S, Suzuki M, Shimizu T
    Rhinology 47(3) 305-309 2009年09月 [査読有り]
  • Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.
    Hattori R, Shimizu S, Majima Y, Shimizu T
    The Annals of otology, rhinology, and laryngology 118(7) 536-541 2009年07月 [査読有り]
  • Role of platelet-derived growth factor in airway remodeling in rhinosinusitis.
    Kouzaki H, Seno S, Fukui J, Owaki S, Shimizu T
    American journal of rhinology & allergy 23(3) 273-280 2009年05月 [査読有り]
  • Endoscopic ligation of the sphenopalatine artery and the maxillary artery for the treatment of intractable posterior epistaxis.
    Seno S, Arikata M, Sakurai H, Owaki S, Fukui J, Suzuki M, Shimizu T
    American journal of rhinology & allergy 23(2) 197-199 2009年03月 [査読有り]
  • Th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats.
    Shimizu S, Hattori R, Majima Y, Shimizu T
    The Annals of otology, rhinology, and laryngology 118(1) 67-72 2009年01月 [査読有り]
  • Role of the coagulation system in allergic inflammation in the upper airways.
    Shimizu S, Shimizu T, Morser J, Kobayashi T, Yamaguchi A, Qin L, Toda M, D'Alessandro-Gabazza C, Maruyama T, Takagi T, Yano Y, Sumida Y, Hayashi T, Takei Y, Taguchi O, Suzuki K, Gabazza EC
    Clinical immunology (Orlando, Fla.) 129(2) 365-371 2008年11月 [査読有り]
  • [Clinical effectiveness of coblation-assisted inferior turbinoplasty].
    Tani T, Seno S, Hanamitsu M, Shimizu T
    Arerugi = [Allergy] 57(8) 1053-1060 2008年08月 [査読有り]
  • EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells.
    Hattori R, Shimizu S, Majima Y, Shimizu T
    The Annals of otology, rhinology, and laryngology 117(1) 51-58 2008年01月 [査読有り]
  • Immunohistochemical and ultrastructural abnormalities in muscle from a patient with sensorineural hearing loss related to a 1555 A-to-G mitochondrial mutation.
    Kouzaki H, Suzuki M, Shimizu T
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 14(6) 603-607 2007年06月 [査読有り]
  • [Endoscopic ligation of maxillary and sphenopalatine artery for intractable epistaxis].
    Arikata M, Seno S, Suzuki M, Sakurai H, Tojima I, Shimizu T
    Nihon Jibiinkoka Gakkai kaiho 109(8) 649-654 2006年08月 [査読有り]
  • Malignant external otitis: treatment with prolonged usage of antibiotics and Burow's solution.
    Shimizu T, Ishinaga H, Seno S, Majima Y
    Auris, nasus, larynx 32(4) 403-406 2005年12月 [査読有り]
  • [Image-guided endoscopic sinus surgery: a comparison of two navigation systems].
    Seno S, Suzuki M, Sakurai H, Kitanishi T, Nakajima D, Sonoda S, Owaki S, Fukui J, Hoshi J, Hanamitsu M, Shimizu T
    Nihon Jibiinkoka Gakkai kaiho 108(11) 1101-1109 2005年11月 [査読有り]
  • Presence of monoamine oxidase type B protein but absence of associated enzyme activity in neurons within the inferior olive nucleus of the rat.
    Kouzaki H, Suzuki M, Shimizu T, Aimi Y, Ito A, Arai R
    Brain research 1055(1-2) 202-207 2005年09月 [査読有り]
  • [Endoscopic resection of benign and malignant tumors in the nasal cavity and paranasal sinus].
    Suzuki M, Sakurai H, Seno S, Hoshi J, Ogawa T, Arikata M, Tojima I, Kitanishi T, Tanaka H, Shimizu T
    Nihon Jibiinkoka Gakkai kaiho 108(7) 724-733 2005年07月 [査読有り]
  • High-pressure grease injury of the face.
    Ishinaga H, Shimizu T, Majima Y
    American journal of otolaryngology 25(4) 278-281 2004年07月 [査読有り]
  • Lipoblastoma of the neck: a case report and literature review.
    Sakaida M, Shimizu T, Kishioka C, Majima Y
    American journal of otolaryngology 25(4) 266-269 2004年07月 [査読有り]
  • In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells.
    Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y
    American journal of respiratory and critical care medicine 168(5) 581-587 2003年09月 [査読有り]
  • [Therapeutic results of respiratory disturbance during sleep in children].
    Kobayashi M, Sakaida H, Yuta A, Takeuchi K, Shimizu T, Majima Y
    Nihon Jibiinkoka Gakkai kaiho 106(8) 815-822 2003年08月 [査読有り]
  • Osteoma of the malleus: a case report and literature review.
    Shimizu T, Okamoto K, Majima Y
    American journal of otolaryngology 24(4) 239-241 2003年07月 [査読有り]
  • A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats.
    Shimizu T, Shimizu S, Hattori R, Majima Y
    The Journal of allergy and clinical immunology 112(1) 119-125 2003年07月 [査読有り]
  • Mucociliary transport function and damage of ciliated epithelium.
    Yang TQ, Majima Y, Guo Y, Harada T, Shimizu T, Takeuchi K
    American journal of rhinology 16(4) 215-219 2002年07月 [査読有り]
  • Pendred's syndrome with goiter and enlarged vestibular aqueducts diagnosed by PDS gene mutation.
    Ishinaga H, Shimizu T, Yuta A, Tsukamoto K, Usami S, Majima Y
    Head & neck 24(7) 710-713 2002年07月 [査読有り]

受賞

  • 1996年 第3回日本鼻科学会賞