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柳沢 大治郎

所属部署名神経難病研究センター
職名准教授
 
 
更新日: 18/03/30 10:41

研究者基本情報

氏名

    柳沢 大治郎

所属(マスタ)

  • 神経難病研究センター 准教授

学歴

  • 2003年04月- 2008年03月京都薬科大学大学院 薬学研究科 薬学専攻
  • 1998年04月- 2003年03月京都薬科大学 薬学部

学位

  • 博士(薬学)(京都薬科大学)

所属学協会

    日本薬理学会 , Society for Neuroscience , 日本分子イメージング学会 , 日本認知症学会 , 日本神経科学学会 , 日本組織細胞化学会

経歴

  • 2015年07月- 現在滋賀医科大学(准教授)
  • 2012年04月- 2015年06月滋賀医科大学(助教)
  • 2011年04月- 2012年03月日本学術振興会(特別研究員PD)
  • 2010年04月- 2011年03月滋賀医科大学(非常勤研究員)
  • 2008年07月- 2010年03月科学技術振興機構(JST)(技術員/研究員)
  • 2008年04月- 2008年06月京都薬科大学(21世紀COEプログラム ポスト・ドクター)

研究活動情報

論文

  • Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions
    Hamezah Hamizah Shahirah, Durani Lina Wati, Ibrahim Nor Faeizah, Yanagisawa Daijiro, Kato Tomoko, Shiino Akihiko, Tanaka Sachiko, Damanhuri Hanafi Ahmad, Ngah Wan Zurinah Wan, Tooyama Ikuo
    EXPERIMENTAL GERONTOLOGY 99 69-79 2017年12月 [査読有り]
  • Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum
    Durani Lina Wati, Hamezah Hamizah Shahirah, Ibrahim Nor Faeizah, Yanagisawa Daijiro, Makpol Suzana, Damanhuri Hanafi Ahmad, Tooyama Ikuo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 493(3) 1356-1363 2017年11月 [査読有り]
  • Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease
    Yanagisawa Daijiro, Oda Keisuke, Inden Masatoshi, Morikawa Shigehiro, Inubushi Toshiro, Taniguchi Takashi, Hijioka Masanori, Kitamura Yoshihisa, Tooyama Ikuo
    JOURNAL OF NEUROSCIENCE RESEARCH 95(7) 1485-1494 2017年07月 [査読有り]
  • DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders
    Hijioka Masanori, Inden Masatoshi, Yanagisawa Daijiro, Kitamura Yoshihisa
    BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(5) 548-552 2017年05月 [査読有り]
  • Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates alpha-synuclein expression
    Guan Hongpeng, Yang Hongkuan, Yang Mingchun, Yanagisawa Daijiro, Bellier Jean-Pierre, Mori Masaki, Takahata Shogo, Nonaka Takashi, Zhao Shiguang, Tooyama Ikuo
    EXPERIMENTAL NEUROLOGY 291 51-61 2017年05月 [査読有り]
  • Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia
    Ogawa Takao, Irikawa Naoya, Yanagisawa Daijiro, Shiino Akihiko, Tooyama Ikuo, Shimizu Takeshi
    AURIS NASUS LARYNX 44(2) 168-173 2017年04月 [査読有り]
  • Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in A beta PP/PS1 Mice
    Ibrahim Nor Faeizah, Yanagisawa Daijiro, Durani Lina Wati, Hamezah Hamizah Shahirah, Damanhuri Hanafi Ahmad, Ngah Wan Zurinah Wan, Tsuji Mayumi, Kiuchi Yuji, Ono Kenjiro, Tooyama Ikuo
    JOURNAL OF ALZHEIMERS DISEASE 55(2) 597-612 2017年 [査読有り]
  • Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease
    Kitamura Yoshihisa, Inden Masatoshi, Kimoto Yasuto, Takata Kazuyuki, Yanagisawa Daijiro, Hijioka Masanori, Ashihara Eishi, Tooyama Ikuo, Shimohama Shun, Ariga Hiroyoshi
    JOURNAL OF ALZHEIMERS DISEASE 55(1) 67-72 2017年 [査読有り]
  • Mitochondrial ferritin affects mitochondria by stabilizing HIF-1 alpha in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration
    Wang Xiying, Yang Hongkuan, Yanagisawa Daijiro, Bellier Jean-Pierre, Morino Katsutaro, Zhao Shiguang, Liu Ping, Vigers Piers, Tooyama Ikuo
    NEUROBIOLOGY OF AGING 47 168-179 2016年11月 [査読有り]
  • Amyloid imaging using fluorine-19 magnetic resonance imaging (F-19-MRI)
    Tooyama Ikuo, Yanagisawa Daijiro, Taguchi Hiroyasu, Kato Tomoko, Hirao Koichi, Shirai Nobuaki, Sogabe Takayuki, Ibrahim Nor Faeizah, Inubushi Toshiro, Morikawa Shigehiro
    AGEING RESEARCH REVIEWS 30 85-94 2016年09月 [査読有り]
  • alpha 4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior
    Inden Masatoshi, Takata Kazuyuki, Yanagisawa Daijiro, Ashihara Eishi, Tooyama Ikuo, Shimohama Shun, Kitamura Yoshihisa
    NEUROCHEMISTRY INTERNATIONAL 94 74-81 2016年03月 [査読有り]
  • Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice
    Yanagisawa Daijiro, Ibrahim Nor Faeizah, Taguchi Hiroyasu, Morikawa Shigehiro, Hirao Koichi, Shirai Nobuaki, Sogabe Takayuki, Tooyama Ikuo
    NEUROBIOLOGY OF AGING 36(1) 201-210 2015年01月 [査読有り]
  • Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds
    Taguchi Hiroyasu, Yanagisawa Daijiro, Morikawa Shigehiro, Hirao Koichi, Shirai Nobuaki, Tooyama Ikuo
    AUSTRALIAN JOURNAL OF CHEMISTRY 68(2) 224-229 2015年 [査読有り]
  • Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer's Disease
    McClure Richard, Yanagisawa Daijiro, Stec Donald, Abdollahian Dave, Koktysh Dmitry, Xhillari Dritan, Jaeger Rudolph, Stanwood Gregg, Chekmenev Eduard, Tooyama Ikuo, Gore John C., Pham Wellington
    JOURNAL OF ALZHEIMERS DISEASE 44(1) 283-295 2015年 [査読有り]
  • Upregulation of Mitochondrial Ferritin by Proinflammatory Cytokines: Implications for a Role in Alzheimer's Disease
    Yang Hongkuan, Guan Hongpeng, Yang Mingchun, Liu Ziyi, Takeuchi Shigeko, Yanagisawa Daijiro, Vincent Steven R., Zhao Shiguang, Tooyama Ikuo
    JOURNAL OF ALZHEIMERS DISEASE 45(3) 797-811 2015年 [査読有り]
  • A Mutation of COX6A1 Causes a Recessive Axonal or Mixed Form of Charcot-Marie-Tooth Disease
    Tamiya Gen, Makino Satoshi, Hayashi Makiko, Abe Akiko, Numakura Chikahiko, Ueki Masao, Tanaka Atsushi, Ito Chizuru, Toshimori Kiyotaka, Ogawa Nobuhiro, Terashima Tomoya, Maegawa Hiroshi, Yanagisawa Daijiro, Tooyama Ikuo, Tada Masayoshi, Onodera Osamu, Hayasaka Kiyoshi
    AMERICAN JOURNAL OF HUMAN GENETICS 95(3) 294-300 2014年09月 [査読有り]
  • Preferred Features of a Fluorine-19 MRI Probe for Amyloid Detection in the Brain
    Yanagisawa Daijiro, Taguchi Hiroyasu, Ibrahim Nor Faeizah, Morikawa Shigehiro, Shiino Akihiko, Inubushi Toshiro, Hirao Koichi, Shirai Nobuaki, Sogabe Takayuki, Tooyama Ikuo
    JOURNAL OF ALZHEIMERS DISEASE 39(3) 617-631 2014年 [査読有り]
  • Mitochondrial ferritin in neurodegenerative diseases
    Yang Hongkuan, Yang Mingchun, Guan Hongpeng, Liu Ziyi, Zhao Shiguang, Takeuchi Shigeko, Yanagisawa Daijiro, Tooyama Ikuo
    NEUROSCIENCE RESEARCH 77(1-2) 1-7 2013年09月 [査読有り]
  • beta-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway
    Kameshima Naoko, Yanagisawa Daijiro, Tooyama Ikuo
    NEUROSCIENCE RESEARCH 76(3) 169-172 2013年07月 [査読有り]
  • Correlation of A beta deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease
    Kameshima Naoko, Nanjou Toshifumi, Fukuhara Takaomi, Yanagisawa Daijiro, Tooyama Ikuo
    NEUROSCIENCE LETTERS 513(2) 166-169 2012年04月 [査読有り]
  • Curcuminoid Binds to Amyloid-beta(1-42) Oligomer and Fibril
    Yanagisawa Daijiro, Taguchi Hiroyasu, Yamamoto Akitsugu, Shirai Nobuaki, Hirao Koichi, Tooyama Ikuo
    JOURNAL OF ALZHEIMERS DISEASE 24 33-42 2011年 [査読有り]
  • Development of a novel F-19 MRI probe for detecting amyloid deposition in Alzheimer's disease
    Yanagisawa Daijiro, Morikawa Shigehiro, Taguchi Hiroyasu, Shiino Akihiko, Inubushi Toshiro, Tooyama Ikuo
    NEUROSCIENCE RESEARCH 71 E85 2011年 [査読有り]
  • Relationship between the tautomeric structures of curcumin derivatives and their A beta-binding activities in the context of therapies for Alzheimer's disease
    Yanagisawa Daijiro, Shirai Nobuaki, Amatsubo Tomone, Taguchi Hiroyasu, Hirao Koichi, Urushitani Makoto, Morikawa Shigehiro, Inubushi Toshiro, Kato Masanari, Kato Fuminori, Morino Kyuya, Kimura Hirohiko, Nakano Ichiro, Yoshida Chikako, Okada Takashi, Sano Mitsuo, Wada Yoshiko, Wada Ken-nosuke, Yamamoto Akitsugu, Tooyama Ikuo
    BIOMATERIALS 31(14) 4179-4185 2010年05月 [査読有り]
  • Amyloid Imaging Using High-Field Magnetic Resonance
    Amatsubo Tomone, Yanagisawa Daijiro, Morikawa Shigehiro, Taguchi Hiroyasu, Tooyama Ikuo
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 9(3) 95-99 2010年 [査読有り]
  • The mRNA Distribution of C7orf24, a gamma-Glutamyl Cyclotransferase, in Rat Tissues
    Oda Keisuke, Makino Satoshi, Masuda Chiaki, Yoshiki Tatsuhiro, Kitamura Yoshihisa, Takata Kazuyuki, Yanagisawa Daijiro, Taniguchi Takashi, Tooyama Ikuo
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 57(12) 1121-1126 2009年12月 [査読有り]
  • Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
    Yamane Koichiro, Kitamura Yoshihisa, Yanagida Takashi, Takata Kazuyuki, Yanagisawa Daijiro, Taniguchi Takashi, Taira Takahiro, Ariga Hiroyoshi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 10(11) 4789-4804 2009年11月 [査読有り]
  • Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7
    Yanagida Takashi, Kitamura Yoshihisa, Yamane Koichiro, Takahashi Kazunori, Takata Kazuyuki, Yanagisawa Daijiro, Yasui Hiroyuki, Taniguchi Takashi, Taira Takahiro, Honda Toshio, Ariga Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 109(3) 463-468 2009年03月 [査読有り]
  • Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury
    Yanagida Takashi, Tsushima Jun, Kitamura Yoshihisa, Yanagisawa Daijiro, Takata Kazuyuki, Shibaike Tomonori, Yamamoto Atsuko, Taniguchi Takashi, Yasui Hiroyuki, Taira Takahiro, Morikawa Shigehiro, Inubushi Toshihiro, Tooyama Ikuo, Ariga Hiroyoshi
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2(1) 36-42 2009年01月 [査読有り]
  • The neuroprotective effects of PARK7 (DJ-1) against oxidative stress-induced neuronal cell death
    Yamamoto Atsuko, Kitamura Yoshihisa, Yanagisawa Daijiro, Takata Kazuyuki, Taniguchi Takashi, Taira Takahiro, Ariga Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 109 274P 2009年 [査読有り]
  • Possible involvement of P2X(7) receptor activation in microglial neuroprotection against focal cerebral ischemia in rats
    Yanagisawa Daijiro, Kitamura Yoshihisa, Takata Kazuyuki, Hide Izumi, Nakata Yoshihiro, Taniguchi Takashi
    BIOLOGICAL & PHARMACEUTICAL BULLETIN 31(6) 1121-1130 2008年06月 [査読有り]
  • DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats
    Yanagisawa Daijiro, Kitamura Yoshihisa, Inden Masatoshi, Takata Kazuyuki, Taniguchi Takashi, Morikawa Shigehiro, Morita Masahito, Inubushi Toshiro, Tooyama Ikuo, Taira Takahiro, Iguchi-Ariga Sanae M. M., Akaike Akinori, Ariga Hiroyoshi
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 28(3) 563-578 2008年03月 [査読有り]
  • Comparative study of effects of transplantation with mouse ES cells on behavioral dysfunction between rat model of Parkinson's disease and focal cerebral ischemia
    Inden Masatoshi, Kitamura Yoshihisa, Yanagisawa Daijiro, Takata Kazuyuki, Taniguchi Takashi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 106 225P 2008年 [査読有り]
  • Application of MR imaging in the study of neurodegenerative disease model rats
    Oda Keisuke, Kitamura Yoshihisa, Takata Kazuyuki, Yanagisawa Daijiro, Taniguchi Takashi, Tooyama Ikuo
    JOURNAL OF PHARMACOLOGICAL SCIENCES 106 226P 2008年 [査読有り]
  • DJ-1 has neuroprotective effects against oxidative stress-induced cell death in human SH-SY5Y cells
    Shibaike Tomonori, Kitamura Yoshihisa, Yanagisawa Daijiro, Takata Kazittyuki, Takashi Taniguchi, Taira Takahiro, Ariga Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 106 189P 2008年 [査読有り]
  • Neuroprotective effects of DJ-1 (PARK7) in rat brain ischemia: A study of magnetic resonance (MR) imaging
    Oda Keisuke, Yanagisawa Daijiro, Kitamura Yoshihisa, Takata Kazuyuki, Taniguchi Takashi, Tooyama Ikuo, Taira Takahiro, Ariga Hiroyoshi
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 128 45 2008年 [査読有り]
  • Neuroprotective effect of DJ-1 on focal cerebral ischemia and reperfusion in rats
    Yanagisawa Daijiro, Kitamura Yoshihisa, Takata Kazuyuki, Taniguchi Takashi, Tooyama Ikuo, Taira Takahiro, Ariga Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 106 51P 2008年 [査読有り]
  • Magnetic resonance (MR) imaging analysis shows neuroprotective effect of PARK7 in ischemic rats
    Kitamura Yoshihisa, Yanagisawa Daijiro, Takata Kazuyuki, Taniguchi Takashi, Tooyama Ikuo, Taira Takahiro, Ariga Hiroyoshi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 106 230P 2008年 [査読有り]
  • Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats
    Takata Kazuyuki, Kitamura Yoshihisa, Yanagisawa Daijiro, Morikawa Shigehiro, Morita Masahito, Inubushi Toshiro, Tsuchiya Daiju, Chishiro Saori, Saeki Mana, Taniguchi Takashi, Shimohama Shun, Tooyama Ikuo
    FEBS LETTERS 581(3) 475-478 2007年02月 [査読有り]
  • Transplantation of mouse embryonic stem cells improves focal ischemia-induced behavioral dysfunction in rats
    Yanagisawa Daijiro, Kitamura Yoshihisa, Taniguchi Takashi
    JOURNAL OF PHARMACOLOGICAL SCIENCES 103 191P 2007年 [査読有り]
  • Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells
    Yanagisawa Daijiro, Qi Meirigeng, Kim Do-hoon, Kitamura Yoshihisa, Inden Masatoshi, Tsuchiya Daiju, Takata Kazuyuki, Taniguchi Takashi, Yoshimoto Kanji, Shimoama Shun, Akaike Akinori, Sumi Shoichiro, Inoue Kazutomo
    NEUROSCIENCE LETTERS 407(1) 74-79 2006年10月 [査読有り]
  • PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model
    Inden Masatoshi, Taira Takahiro, Kitamura Yoshihisa, Yanagida Takashi, Tsuchiya Daiju, Takata Kazuyuki, Yanagisawa Daijiro, Nishimura Kaneyasu, Taniguchi Takashi, Kiso Yoshiaki, Yoshimoto Kanji, Agatsuma Tomohiro, Koide-Yoshida Shizuyo, Iguchi-Ariga Sanae M. M., Shimohama Shun, Ariga Hiroyoshi
    NEUROBIOLOGY OF DISEASE 24(1) 144-158 2006年10月 [査読有り]
  • Focal ischemia-induced neuronal death and microglial function
    Kitamura Yoshihisa, Yanagisawa Daijiro, Takata Kazuyuki, Taniguchi Takashi
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 125 53-56 2005年 [査読有り]
  • Exogenous microglia protect against focal brain ischemia in rats
    Yanagisawa Daijiro, Kitamura Yoshihisa, Taniguchi Takashi
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 125 130-132 2005年 [査読有り]

MISC

  • Curcumin against amyloid pathology in mental health and brain composition
    Ikuo Tooyama, Nor Faeizah Ibrahim, Nor Faeizah Ibrahim, Lina Wati Durani, Lina Wati Durani, Hamizah Shahirah Hamezah, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi, Daijiro Yanagisawa
    Fruits, Vegetables, and Herbs: Bioactive Foods in Health Promotion 487-505 2016年05月
    © 2016 Elsevier Inc. All rights reserved.Recent evidence suggests that amyloid pathology occurs 10-20 years before the clinical onset of Alzheimer's disease (AD). Accordingly, modulating abnormal amyloid-β (Aβ) aggregation is now considered as a potential therapeutic target in AD. Curcumin, a low molecular weight polyphenol derived from the well-known spice turmeric, has various pharmacological properties, including antitumor, antioxidative, antiinflammatory, and antiamyloid effects. Curcumin binds both Aβ fibrils and oligomers and inhibits Aβ aggregation as well as Aβ-related oxidative stress and inflammation. The keto-enol tautomerism of curcumin is involved in its binding to Aβ aggregates. The enol form, but not the keto form, of curcumin can bind to Aβ aggregates. When curcumin was administered to transgenic mouse models of AD, it effectively suppressed amyloid pathology in the mouse brain. However, the results of early clinical trials of curcumin for AD have been negative, probably due to its low bioavailability. Several approaches have been proposed to improve the bioavailability of curcumin.
  • [Glutaminergic neurotransmission in Alzheimer's disease].
    Tooyama I, Yanagisawa D
    Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 8 214-218 2011年10月 [査読有り]

特許

  • ケト・エノール互変異性を利用した診断薬
    特願2009-45531

受賞

  • 2017年05月 第12回日本分子イメージング学会総会・学術集会 FASMI Young Investigator Travel Award
  • 2012年11月 第24回日本脳循環代謝学会総会 Young Investigator’s Award
  • 2010年02月 第10回バイオビジネスコンペJAPAN 奨励賞
  • 2008年03月 第81回日本薬理学会年会 年会優秀発表賞