NOZAKI Kazuhiko

FacultyDepartment of Neurosurgery
Last Updated: Feb. 08, 2018 at 11:01

Researcher Profile & Settings


    NOZAKI Kazuhiko

Affiliation (Master)

  • Department of Neurosurgery


  • 1990Kyoto University Graduate School, Division of Medicine
  • 1983Kyoto University Faculty of Medicine

Research Activities

Research Areas

  • Clinical surgery / Cerebral neurosurgery

Published Papers

  • Preemptive Medicine for Cerebral Aneurysms.
    Aoki T, Nozaki K
    Neurologia medico-chirurgica 56(9) 552-568 Sep. 2016 [査読有り]
  • mTORC1 signaling in primary central nervous system lymphoma.
    Nitta N, Nakasu S, Shima A, Nozaki K
    Surgical neurology international 7(Suppl 17) S475-80 Jul. 2016 [査読有り]
  • Primary pericranial Ewing's sarcoma on the temporal bone: A case report.
    Kawano H, Nitta N, Ishida M, Fukami T, Nozaki K
    Surgical neurology international 7(Suppl 15) S444-8 Jun. 2016 [査読有り]
  • Straight sinus thrombosis during neurosurgical operation.
    Kawano H, Nitta N, Nozaki K
    Surgical neurology international 7 50 May 2016 [査読有り]
  • Trigeminal Neuralgia Attributable to Intraneural Trigeminocerebellar Artery: Case Report and Review of the Literature.
    Jito J, Nozaki K
    World neurosurgery 88 687.e7-11 Apr. 2016 [査読有り]
  • Direct Microsurgical Embolectomy for Acute Occlusion of the Internal Carotid Artery and Middle Cerebral Artery.
    Hino A, Oka H, Hashimoto Y, Echigo T, Koseki H, Fujii A, Katsumori T, Shiomi N, Nozaki K, Arima H, Hashimoto N
    World neurosurgery 88 243-251 Apr. 2016 [査読有り]
  • [Arteriovenous Malformation Treatment after ARUBA study].
    Tsuji A, Nakazawa T, Nozaki K
    No shinkei geka. Neurological surgery 44(4) 269-281 Apr. 2016 [査読有り]
  • Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor.
    Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, Fukuda M, Saiki M, Hojo M, Miyamoto S, Onishi N, Saya H, Inubushi T, Nozaki K, Tanigaki K
    PloS one 11(2) e0149826 Feb. 2016 [査読有り]
  • A Prospective and Retrospective Study of Cerebral AVM Treatment Strategies 1990-2014.
    Tsuji A, Nozaki K
    Acta neurochirurgica. Supplement 123 135-139 2016 [査読有り]
  • Recurrent subdural hematoma secondary to headbanging: A case report.
    Nitta N, Jito J, Nozaki K
    Surgical neurology international 6(Suppl 18) S448-50 Oct. 2015 [査読有り]
  • Statin use and risk of cerebral aneurysm rupture: a hospital-based case-control study in Japan
    J Stroke Cereb Vasc Dis 23(2) 343-348 2014
  • Selection of semi-sitting position in neurosurgery: Essential or preference?
    World Neurosurgery 81(1) 62-63 2014
  • Role of burr hole surgery in patients with moyamoya disease.
    World Nuerosurgery 81(1) 27-28 2014
  • Suppression of cerebral aneurysm formation in rats by a tumor necrosis factor-a inhibitor
    J Neurosurg 120 1193-1200 2014
  • Morphometric characterization of Binswanger's disease: Comparison with Alzheimer's disease.
    Eur J Radiol 81 2375-2379 2012
  • Surgical Intervention for Cerebral Ischemia: Effective or not?
    World Neurosurgery  78 45-46 2012
  • Intra-arterial infusion therapy for cerebral vasospasm: promising but preliminary
    World Neurosurgery  78 223-225 2012
  • Transplantation of telencephalic neural progenitors induced from embryonic stem cells into subacute phase of focal cerebral ischemia.
    Lab Invest 92 522-531 2012
  • The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort.
    N Engl J Med 366 2474-2482 2012
  • Inadequate communication between patients with unruptured cerebral aneurysms and neurosurgeons
    Neurol Med Chir (Tokyo) 52 873-877 2012
  • Growth curve analysis of asymptomatic and symptomatic meningiomas.
    J Neurooncol(102) 303-310 2011
  • Aoki T, Nishimura M, Matsuoka T, Yamamoto K, Furuyashiki T, Kataoka H,Kitaoka S, Ishibashi R, Ishibazawa A, Miyamoto S, Morishita R, Ando J,
    PGE(2) -EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB.(163) 1237-1249 2011
  • Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS.
    Lab Invest (91) 619-626 2011
  • Benefits and risks of radiosurgery to brainstem arteriovenous malformations
    World Neurosurgery(76) 57-58 2011
  • Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells.
    J Neurosci Res(89) 1388-1399 2011
  • Transdifferentiation of bone marrow-derived endothelial progenitor cells into the
    Atherosclerosis(211) 114-121 2010
  • Practical Decision-Making in the Treatment of Unruptured Cerebral Aneurysm in Japan: The U-CARE Study.
    Cerebrovasc Dis(30) 491-499 2010
  • Impact of monocyte chemoattractant protein-1-deficiency on cerebral aneurysm formation.
    Stroke(40) 942-951 2009
  • Reactive oxygen species are responsible for cerebral aneurysm formation: study using p47phox-/- mice and the free radical scavenger 'edaravone'
    Laboratory Investigation 89 730-741 2009
  • Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia.
    Brain Res 1272 62-70 2009
  • Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke.
    J Cereb Blood Flow Metab 29 1409-1420 2009
  • RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis
    Dev Biol 332 339-350 2009
  • Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme.
    J Neurosurg 112 50-56 2009
  • Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm. Contribution of Interleukin-1{beta} and Nuclear Factor-{kappa}B.
    Arterioscler Thromb Vasc Biol  29 1080-1086 2009
  • Autosomal dominant moyamoya disease maps to chromosome 17q25.3
    Neurology(70) 2357-2363 2008
  • Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats
    Stroke (39) 1276-1285 2008
  • Effect of early optic canal unroofing on the outcome of visual functions in surgery for meningiomas of the tuberculum sellae and planum sphenoidale
    Neurosurgery(62) 839-846 2008
  • Cathepsin B, K and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms
    Stroke(39) 2603-2610 2008
  • Tissue Inhibitor of Metalloproteinases Protect Blood Brain Barrier Disruption in Focal Cerebral Ischemia
    J Cereb Blood Flow Metab(28) 1674-1685 2008
  • Gene Expression during the Development of Experimentally Induced Cerebral Aneurysms
    J Vasc Res(45) 343-349 2008
  • Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23
    J Hum Genet(53) 325-332 2008
  • Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappa B pathway
    Neurosurgery  64 357-365 2008
  • Nifedipine Inhibits the Progression of An Experimentally Induced Cerebral Aneurysm in Rats with Associated Down-Regulation of NF-Kappa B Transcriptional Activity.
    Curr Neurovasc Res 5 1 37-45 2008
  • The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation.
    Int J Mol Med 21(4) 453-459 2008
  • Targeted disruption of Hsp110/105 gene protects against ischemic stress
    Stroke 39 2853-2859 2008
  • Cerebral aneurysm progression suppressed by blockage of endothelin B receptor
    J Neurosurg(106) 330-336 2007
  • Administration of ex vivo-expanded bone marrow-derived endothelial progenitor cells attenuates focal cerebral ischemia-reperfusion injury in rats
    Neurosurgery(59) 679-686 2007
  • Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats
    Stroke (38) 162-169 2007
  • Model-based linkage analyses confirm chromosome 19q13.3 as a susceptibility locus for intracranial aneurysm
    Stroke(38) 1174-1178 2007
  • Neuronal expression of Fas-associated death domain protein and caspase-8 in the perinidal parenchyma of cerebral arteriovenous malformations
    J Neurosurg(106) 275-282 2007
  • Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms.
    Stroke (38) 2337-2345 2007
  • alpha-Klotho as a regulator of calcium homeostasis
    Science(316) 1615-1618 2007
  • Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations
    J Neurosurg(107) 965-972 2007
  • NF-(kappa)B is a key mediator of cerebral aneurysm formation
    Circulation(116) 2830-2840 2007
  • Proliferarive activity through extracellular signal-regulated kinase of smooth muscle cells in the vascular walls of cerebral arteriovenous malformations
    Neurosurgy (58) 740-748 2006
  • Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 To Intracranial Aneurysm
    Stroke(37) 1189-1194 2006
  • Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain
    J Cereb blood Flow Metab(26) 906-914 2006
  • Impaired progression of cerebral aneurysms in interleukin-1b-deficient mice
    Stroke(37) 900-905 2006
  • Surgical application to arteriovenous malformations involving the brainstem
    Neurosurgery(58) ONS-270-276 2006
  • Search on chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for Intracranial aneurysm: a preliminary study
    Circulation(113) 2002-2010 2006
  • Optic strut as a radiographic landmark in evaluating neck location of a paraclinoid aneurysm
    Neurosurgery(59) 880-887 2006
  • Caspase-3-dependent apoptosis in middle cerebral arteries in patients with moyamoya disease
    Neurosurgery(59) 894-901 2006
  • Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting
    J Neurology Neurosurgery Psychiatry(77) 1025-1029 2006
  • Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain
    J Neurosurg(103) 304-310 2005
  • Dual roles for DNA polymerase h in homologous DNA recombination and translesion DNA synthesis
    Mol Cell(20) 793-799 2005
  • High Expression of Aurora-B/Aurora and Ipl1-like midbody-associated protein (AIM-1) in astrocytomas
    J Neurooncol(67) 53-64 2004
  • Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane
    FEBS Lett(565) 143-147 2004
  • Genome-Wide Scan for Japanese Familial Intracranial Aneurysms: Linkage to Several Chromosomal Regions
    Circulation(110) 3727-3733 2004
  • Adenovirus-mediated gene transfer of fibroblast growth factor-2 increases BrdU-positive cells after forebrain ischemia in gerbils
    Stroke(34) 1519-1525 2003
  • Absence of linkage of familial intracranial aneurysms to 7q.11 in highly aggregated Japanese families
    Stroke(34) 892-900 2003
  • Control of axon elongation via an SDF-1a/Rho/mDia pathway in cultured cerebellar granule neurons
    J Cell Biol(161) 381-391 2003
  • Involvement of extracellular Ca2+ influx and epidermal growth factor receptor tyrosine kinase transactivation in endothelin-1-induced arachidonic acid release
    Br J Pharmacol(139) 1516-1522 2003
  • Activation of p38 kinase in the gerbil hippocampus showing ischemic tolerance
    J Cereb Blood Flow Metab(23) 1052-1059 2003
  • Disruption of gene for inducible nitric oxide synthase reduces progression of cerebral aneurysms.
    Stroke(34) 2980-2984 2003
  • Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant Endothelin A receptor
    Molecular Pharmacol (61) 277-284 2002
  • Mitogen-activated protein kinases and cerebral ischemia
    Molecular Neurobiology(23) 1-19 2001
  • Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus
    J Neurosci (20) 4506-4514 2000
  • Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase
    Circulation(101) 2532-2538 2000
  • Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage
    Proc Natl Acad Sci (USA) (96) 4131-4136 1999
  • Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat: Immunohistochemical and hybridization studies of thioredoxin
    J Cereb Blood Flow Metab(18) 206-214 1998
  • Expression of thioredoxin is enhanced in atherosclerotic plaques and during neointima formation in rat arteries
    Laboratory Investigation(78) 957-966 1998
  • Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain
    Journal Cerebral Blood Flow & Metabolism(18) 991-997 1998
  • Expression of c-fos-like immunoreactivity in brain stem after meningeal irritation by blood in the subarachnoid space
    Neuroscience(49) 669-680 1993
  • Neocortical spreading depression provokes the expression of c-fos-like immunoreactivity within trigeminal nucleus caudalis
    Journal of Neuroscience(13) 1167-1177 1993
  • Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries
    Journal of Cerebral Blood Flow and Metabolism (13) 70-79 1993
  • Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats
    Journal of Cerebral Blood Flow and Metabolism(13) 221-228 1993
  • Neuroprotective effects of l-kynurenine on hypoxia-ischemia and NMDA
    Journal of Cerebral Blood Flow and Metabolism(12) 400-407 1992
  • CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges
    British Journal of Pharmacology(106) 409-415 1992
  • Vascular relaxation properties of calcitonin gene-related peptide and vasoactive intestinal polypeptide in subarachnoid hemorrhage
    Journal of Neurosurgery(72) 792-797 1990
  • Origins and distribution of cerebrovascular nerve fibers showing calcitonin gene-related peptide-like immunoreactivity in the major cerebral artery of the dog
    Journal of Comparative Neurology(297) 212-226 1990


  • Critical role of TNF-alpha-TNFR1signaling in intracranial aneurysm formation.
    Acta Neuropathologica Communications 2(1) 34 2014

Research Grants & Projects

  • Cerebral aneurysm, Cerebral ischemia, Glioma

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